Q-switched thulium laser thrombus ablation device

Abstract

The application provides a Q-switched thulium laser thrombus ablation device, comprising a Q-switched thulium laser generating assembly for generating Q-switched thulium laser; a thrombus ablation catheter comprising a catheter main body, an optical fiber and an optical fiber driving assembly; the optical fiber is arranged in the catheter main body and is used for obtaining Q-switched thulium laser and emitting the Q-switched thulium laser towards a thrombus in a blood vessel; the optical fiber driving assembly comprises a transmission member and an optical fiber driving unit, the transmission member is arranged between the catheter main body and the optical fiber, and the transmission member is in transmission connection with the optical fiber; one end of the transmission member extends to the outside of the catheter main body and is in transmission connection with the optical fiber driving unit.

Description

TECHNICAL FIELD

[0001] The application belongs to the field of medical surgical laser equipment, and particularly relates to a Q-switched thulium laser thrombus ablation device. BACKGROUND

[0002] Thrombus is the main cause and complication of cardiovascular disease, which can cause myocardial infarction, acute ischemic stroke or venous thromboembolism. When fibrin, red blood cells, platelets and white blood cells and other tissues deposit and coagulate in the blood vessels, thrombus is formed, which destroys blood flow. Different thrombi in different parts of the human body, different formation rates and different areas differ in structure, but all cause damage to the body. At present, the morbidity of thrombus is very high, and a quick, effective and safe thrombus ablation technology is a favorable means to maintain human health and reduce social burden.

[0003] Laser thrombolysis is closely related to wavelength, pulse width and power. Pulsed laser has the advantages of high intensity, high precision, small damage to surrounding tissues, few postoperative complications and the like. Therefore, it is widely used in clinical medicine. Different biological tissues have the characteristics of absorbing different specific wavelengths of laser. The mechanism of laser thrombolysis mainly includes photochemical effect, photothermal effect and photomechanical effect. The specific wavelength laser is used to act on the thrombus, to destroy the molecular bonds of biological tissues or to ablate the tissues directly through thermal effect, so as to achieve the purpose of thrombolysis, which is the mechanism of laser thrombolysis. The biological tissue can be effectively absorbed by laser, which can more easily achieve precise, effective and safe thrombolysis effect.

[0004] The existing thrombus ablation device has unsatisfactory treatment effect, and it is urgent to provide a thrombus ablation device based on laser thrombolysis. SUMMARY

[0005] The application provides a Q-switched thulium laser thrombus ablation device, which can ensure good thrombus ablation effect and less damage to the human body by laser. The application comprises the following steps:

[0006] A Q-switched thulium laser generating assembly is arranged to generate Q-switched thulium laser;

[0007] A thrombus ablation catheter comprises a catheter main body, an optical fiber and an optical fiber driving assembly;

[0008] The optical fiber is arranged in the catheter main body, and is used to obtain Q-switched thulium laser and emit the Q-switched thulium laser towards thrombus in a blood vessel;

[0009] The optical fiber driving assembly comprises a transmission member and an optical fiber driving unit, the transmission member is arranged between the catheter main body and the optical fiber, and the transmission member is in transmission connection with the optical fiber; one end of the transmission member extends to the outside of the catheter main body and is in transmission connection with the optical fiber driving unit.

[0010] Optionally, the pulse width of the Q-switched thulium laser is 30-1000 ns.

[0011] Optionally, the repetition frequency of the Q-switched thulium laser is 200 Hz-200 kHz.

[0012] Optionally, the average power of the Q-switched thulium laser is 0-30 W.

[0013] Optionally, the diameter of the moving optical fiber is 50-600 μm.

[0014] Optionally, the thulium laser generating device adopts a master oscillator power amplifier structure, and comprises:

[0015] a seed light generating assembly and a laser amplification assembly connected in sequence through a thulium-doped optical fiber;

[0016] The seed light generating assembly is configured to generate seed light of the thulium laser, and comprises:

[0017] The first grating and the second grating are arranged in sequence between the acousto-optic modulation device, the first laser, and the first pump light stripping unit, and a first laser isolation unit arranged after the second grating, and the first laser isolation unit is configured to control unidirectional transmission of the seed light.

[0018] The laser amplification assembly is configured to amplify the seed light to form the thulium laser meeting the requirements, and comprises a plurality of second lasers, a second pump light stripping unit, and a second laser isolation unit coupled with the thulium-doped optical fiber, and the second laser isolation unit is configured to control unidirectional transmission of the thulium laser.

[0019] Optionally, the optical fiber driving unit comprises a driving motor, the transmission member is a transmission pipe, the inner surface of the transmission pipe has a plurality of protruding portions, the surface of the protruding portions is covered with a coating layer, and the coating layer comprises a rubber coating layer.

[0020] Optionally, the Q-switched thulium laser thrombus ablation device further comprises:

[0021] The infusion assembly comprises an infusion unit and an infusion pipeline, and the infusion pipeline is a gap between the protruding portions.

[0022] Optionally, the Q-switched thulium laser treatment device has a first working mode and a second working mode.

[0023] In the first working mode, a cavity is provided between the optical fiber and the end of the catheter body close to the thrombus, and the cavity is in communication with the infusion pipeline.

[0024] In the second working mode, the end of the optical fiber and the catheter body close to the thrombus are flush.

[0025] Optionally, the Q-switched thulium laser thrombus ablation device further comprises:

[0026] The expansion assembly comprises an expansion member driving unit and an expansion member, the expansion member is arranged outside the catheter body, and the expansion member driving unit is used for driving the expansion member to expand or contract.

[0027] The technical scheme provided by the present application has the beneficial effects that:

[0028] The present application provides a Q-switched thulium laser thrombus ablation device, comprising a Q-switched thulium laser generating assembly and a thrombus ablation catheter, the thrombus ablation catheter comprising a catheter body, an optical fiber and an optical fiber driving assembly. The Q-switched thulium laser generating assembly is used for generating Q-switched thulium laser, and the thrombus ablation catheter is used for sending the Q-switched thulium laser to the thrombus in the blood vessel of the patient. The optical fiber is arranged in the catheter body, and by controlling the movement of the thrombus ablation catheter, the optical fiber can be moved to the thrombus. The optical fiber driving assembly is used for further accurately controlling the position of the optical fiber in the catheter body, so as to accurately control the distance between the optical fiber and the thrombus. In the present application, the nanosecond fiber thulium laser (Q-switched thulium laser) with high peak power is formed and output to the in-vivo lumen environment for surgical treatment. The high peak power of the Q-switched thulium laser can better realize the effects of thermal ablation and thermal blasting, and the narrow pulse width of the Q-switched thulium laser can effectively prolong the thermal relaxation time of the tissue, so as to avoid the temperature around the treatment point from rising to a degree that damages normal tissues. By using the Q-switched thulium laser for thrombus ablation, the thrombus ablation effect can be ensured, and the damage of the laser to the human body can be avoided. By the optical fiber driving assembly, the distance between the optical fiber and the thrombus lesion can be controlled, and by changing the distance, the dominance of the photo-mechanical effect or the photo-acoustic effect in the thrombus ablation process can be adjusted to adapt to the needs in different blood vessel environments. BRIEF DESCRIPTION OF DRAWINGS

[0029] In order to more clearly illustrate the technical solutions in the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or the prior art description. Obviously, the drawings in the following description are some embodiments of the present application, and other drawings can also be obtained by those skilled in the art without any creative effort.

[0030] Figure 1 A structure schematic diagram of a Q-switched thulium laser thrombus ablation device provided by the present application;

[0031] Figure 2 A structure schematic diagram of a Q-switched thulium laser generating assembly provided by the present application;

[0032] Figure 3 A structure schematic diagram of a thrombus ablation catheter provided by the present application;

[0033] Figure 4Another structure schematic view of the thrombus ablation catheter provided for the embodiment.

[0034] The reference signs are as follows:

[0035] 1: Q-switched thulium laser generating assembly; 11: seed light generating assembly; 111: first grating; 112: acousto-optic modulation device; 113: first laser; 114: first beam combiner; 115: first pump light stripping unit; 116: second grating; 117: first laser isolation unit; 12: laser amplification assembly; 121: second laser; 122: second beam combiner; 123: second pump light stripping unit; 124: second laser isolation unit; 13: thulium-doped optical fiber;

[0036] 2: thrombus ablation catheter; 21: catheter main body; 22: optical fiber; 23: optical fiber driving assembly; 231: transmission member; 2311: transmission tube; 2312: protruding part; 232: optical fiber driving unit;

[0037] 3: infusion assembly; 31: infusion unit; 32: infusion pipeline;

[0038] 4: expansion assembly; 41: expansion member driving unit; 42: expansion member; 43: delivery pipeline. DETAILED DESCRIPTION

[0039] In order to make the objects, technical solutions and advantages of the present application clearer, the technical solutions in the present application will be described clearly and completely below in combination with the drawings in the present application. Obviously, the described embodiments are some of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all the other embodiments obtained by those skilled in the art without creative labor fall within the protection scope of the present application.

[0040] Before formally introducing the technical solutions of the present application, the main inventive concept of the present application will be briefly introduced:

[0041] First, about thulium laser.

[0042] The existing thulium laser is usually used for crushing stones in the medical field, and the present application is to use the thulium laser for thrombus ablation. The basic principle is as follows: the wavelength of the thulium laser is in the strong absorption peak of water, and it can be completely absorbed by water in a very short distance, which can better vaporize and cut the tissue, and has higher cutting precision. When the thulium laser is close to the water-rich tissue, precise ablation can be achieved, and it will not further transmit and diffuse; when the thulium laser is far away from the target tissue in the liquid environment, the liquid medium such as water absorbs the laser energy to form a cavity, and generates a strong shock wave and a high-speed microjet, which can also effectively remove the thrombus and plaque. The clearing effect on the plaque is more remarkable. However, due to the complete absorption of thulium laser energy in a very short distance, it is easy to cause local temperature rise too fast, resulting in unnecessary thermal damage.

[0043] Second, the thulium laser is operated by Q.

[0044] The instantaneous extremely high power of the Q-switched thulium laser can produce a micro-explosion effect on biological tissue, combining the advantages of photothermal effect and photo-mechanical effect, and concentrating the impact force and thermal influence area in the target area, greatly reducing the damage of shock wave and thermal diffusion to the surrounding tissue. Moreover, the beam quality and collimation characteristics of the Q-switched thulium laser are good, and it has high energy density and low loss, which is an ideal choice for laser medical treatment. In the present application, through the self-developed Q-switched optical path, the thulium laser realizes ultra-short pulse width and ultra-high peak power output. In the implementation process, the same output energy can be concentrated in a shorter time, so that the heat relaxation time per unit time will be more sufficient, combined with pulse shaping technology, greatly reducing the additional thermal effect of thulium laser. (That is, first, the ultra-short pulse width and ultra-high peak power output are realized by Q-switching; second, high peak power and short pulse width are beneficial to reduce long-term heat accumulation, which makes up for the inherent disadvantage of traditional thulium laser in thrombus ablation.)

[0045] Based on the above principle, the present application forms a Q-switched thulium laser treatment system for thrombus ablation to ensure the ablation effect of thrombus, and the thulium laser will not cause damage to the human body. The specific technical scheme is shown in the following embodiments.

[0046] Figure 1 A structure diagram of a Q-switched thulium laser thrombus ablation device provided by the present application is shown in Figure 1 , which comprises:

[0047] The Q-switched thulium laser generating assembly 1 is used for generating Q-switched thulium laser;

[0048] Figure 3 A structure diagram of a thrombus ablation catheter provided by the present application is shown in Figure 1 and Figure 3 , the thrombus ablation catheter 2 comprises a catheter main body 21, an optical fiber 22 and an optical fiber driving assembly 23;

[0049] The optical fiber 22 is arranged in the catheter body 21, used for obtaining Q-switched thulium laser and emitting the Q-switched thulium laser to the thrombus in the blood vessel;

[0050] The optical fiber driving assembly 23 comprises a transmission member 231 and an optical fiber driving unit 232, the transmission member 231 is arranged between the catheter body 21 and the optical fiber 22, and the transmission member 231 is in transmission connection with the optical fiber 22; one end of the transmission member 231 extends to the outside of the catheter body 21 and is in transmission connection with the optical fiber driving unit 232.

[0051] The application provides a Q-switched thulium laser thrombus ablation device, which comprises a Q-switched thulium laser generation assembly and a thrombus ablation catheter, and the thrombus ablation catheter comprises a catheter body, an optical fiber and an optical fiber driving assembly. The Q-switched thulium laser generation assembly is used for generating Q-switched thulium laser, and the thrombus ablation catheter is used for sending the Q-switched thulium laser to the thrombus in the blood vessel of a patient. The optical fiber is arranged in the catheter body, and the optical fiber can be moved to the thrombus by controlling the movement of the thrombus ablation catheter. The optical fiber driving assembly is used for further accurately controlling the position of the optical fiber in the catheter body, so that the distance between the optical fiber and the thrombus can be accurately controlled. In the application, nanosecond fiber thulium laser (Q-switched thulium laser) with high peak power is formed and output to the in-vivo lumen environment for surgical treatment. The high peak power of the Q-switched thulium laser can better realize thermal ablation and thermal blasting effect, and the narrow pulse width of the Q-switched thulium laser can effectively prolong the thermal relaxation time of the tissue, so that the temperature around the treatment point can be prevented from rising to a degree that damages normal tissue. By using the Q-switched thulium laser for thrombus ablation, the thrombus ablation effect can be ensured, and the damage of the laser to the human body can be avoided. By using the optical fiber driving assembly, the distance between the optical fiber and the thrombus lesion can be controlled, and the dominance of the photo-mechanical effect or the photo-acoustic effect in the thrombus ablation process can be adjusted by the distance change, so that the requirements in different blood vessel environments can be met.

[0052] In the embodiment, the Q-switched thulium laser generation assembly 1 can adopt any one of the Q-switched thulium laser generation assembly 1 and the Q-switched thulium laser generation assembly 1.

[0053] Figure 2 A structure diagram of the Q-switched thulium laser generation assembly provided by the application is provided. Referring to Figure 2 , the thulium laser generation device 1 adopts a master oscillator power amplifier structure, comprising:

[0054] The seed light generation assembly 11 and the laser amplification assembly 12 connected in sequence through the thulium-doped optical fiber 13;

[0055] The seed light generation assembly 11 is used for generating seed light of thulium laser, comprising:

[0056] The first grating 111 and the second grating 116 are arranged in sequence between the acousto-optic modulation device 112, the first laser 113 and the first pump light stripping unit 115, and the first laser isolation unit 117 arranged after the second grating, and the first laser isolation unit is used for controlling the one-way transmission of the seed light;

[0057] The laser amplification assembly 12 is used for amplifying the seed light to form a required thulium laser, and includes a plurality of second lasers 121 coupled with the thulium-doped optical fiber, a second pump light stripping unit 123 and a second laser isolation unit 124, and the second laser isolation unit 123 is used for controlling the one-way transmission of the thulium laser.

[0058] In the embodiment, the first laser 113 is coupled into the thulium-doped optical fiber 13 through the first beam combiner 114, and the second laser 121 is coupled into the thulium-doped optical fiber 13 through the second beam combiner 122.

[0059] In the embodiment, the first laser 113 and the second laser 121 are pump sources, and include semiconductor lasers.

[0060] In the embodiment, a pulse signal generator can be used to provide an input signal for the acousto-optic modulation device 112.

[0061] In the embodiment, the thulium-doped optical fiber 13 is a double-clad thulium-doped optical fiber.

[0062] In the embodiment, the first pump light stripping unit 115 and the second pump light stripping unit 123 include cladding light strippers.

[0063] In the embodiment, the first laser isolation unit 117 and the second laser isolation unit 124 are isolators.

[0064] In the embodiment, the seed source of the acousto-optic Q-switch mainly comprises a first grating (i.e. a high-reflectivity grating), an acousto-optic modulation device, a first laser (i.e. a semiconductor laser), a first beam combiner, a double-clad thulium-doped fiber, a cladding light stripper, and a second grating (i.e. a low-reflectivity grating). The acousto-optic modulation device with a fiber pigtail at both ends is inserted into the cavity and used as an active Q-switching device. A pulse signal generator provides a driving signal for the acousto-optic modulation device, so that the frequency and duty cycle of the laser can be conveniently adjusted. The pump source is a 30 W semiconductor laser (103). The pump light is coupled into a double-clad thulium-doped fiber with a core diameter of 10 μm and a cladding diameter of 130 μm through a (1+1) * 1 beam combiner. A pair of high-reflectivity and low-reflectivity gratings with a center wavelength of 1940 nm form a resonant cavity to oscillate and select the wavelength of the outgoing laser. The cladding light stripper is used to strip the remaining pump light. After the laser is emitted from the low-reflectivity grating, it passes through a first laser isolation unit (i.e. an isolator) to prevent the return light from adversely affecting the optical path and ensure the unidirectional propagation of the light beam.

[0065] The amplification stage (i.e. a laser amplification assembly) adopts two 35 W 793 nm semiconductor lasers. The (2+1) * 1 beam combiner is used to couple the pump light into a double-clad thulium-doped fiber with a core diameter of 25 μm and a cladding diameter of 250 μm. The seed light is gain-amplified, and then the remaining pump light is stripped through a second laser stripping unit (i.e. a cladding light stripper). Finally, the nanosecond pulse thulium laser with adjustable timing is output through a second laser isolation unit (i.e. an isolator). The center wavelength of the output light is 1940 nm.

[0066] In the embodiment, the pulse width of the Q-switched thulium laser is in the nanosecond range, and the value range is 30-1000 ns.

[0067] For example, the pulse width of the Q-switched thulium laser can be 500 ns.

[0068] In the embodiment, the Q-switched thulium laser with a pulse width in the nanosecond range has a single-pulse duration that is one order of magnitude less than the laser-induced bubble annihilation time (which is in the microsecond range), so that the laser can not penetrate the liquid layer to harm human tissues when working at a certain distance.

[0069] In the embodiment, the peak power of the Q-switched thulium laser is 0-20 kW, and the average power of the Q-switched thulium laser is 0-30 W.

[0070] For example, the peak power of the Q-switched thulium laser is 50 kW, and the average power of the Q-switched thulium laser is 20 W.

[0071] In this embodiment, increasing the peak power is beneficial for the explosive ablation of hard thrombi. The average power is kept below 30 watts to meet the tissue ablation requirements, while avoiding the temperature rise caused by high average power, which could result in additional thermal damage.

[0072] In this embodiment, the repetition rate of the Q-switched thulium laser is 200Hz~200kHz.

[0073] For example, the repetition rate of the Q-switched thulium laser is 100 kHz.

[0074] In this embodiment, the repetition rate is adjustable over a wide range. Low repetition rate is beneficial for the ablation of soft thrombi, while high repetition rate is beneficial for the ablation of hard thrombi. At the same time, it has a larger pulse width shaping space, which can realize complex temporal distributions of pulse width, such as pulse trains and Moses pulses.

[0075] In this embodiment, the wide range of tunable peak power, pulse width, and repetition rate distributions can be combined to achieve complex spatiotemporal pulse width distributions, such as pulse trains and Moses pulses. Both are combinations of multiple pulses. Ordinary pulsed lasers consist of one pulse after another, while each pulse in a pulse train or Moses pulse is composed of multiple smaller pulses. The peak power of each smaller pulse does not need to be the same, and the number of smaller pulses can be set as needed, providing a great deal of editing space. This mode has a wide range of applications and can flexibly allocate energy. For example, in the ablation of biological tissue, it can be used for applications such as micro-drilling, cutting, and surface treatment. By distributing energy through multiple pulses, the uniformity and controllability of material removal can be ensured, and it can be used to cope with more complex application scenarios.

[0076] Figure 4 This is a schematic diagram of another thrombolysis catheter provided in this embodiment. See also... Figure 4 , Figure 4 For Figure 3 Cross-sectional view of the dashed line AA'.

[0077] See also Figure 3 and Figure 4 In this embodiment, the fiber optic drive unit 232 includes a drive motor, the transmission component 231 includes a transmission tube 2311, the inner surface of the transmission tube 231 has a plurality of protrusions 2312, the surface of the protrusions 2312 is covered with a coating, the coating including a rubber coating.

[0078] In this embodiment, the transmission tube 231 and the conduit body 21 can be smoothed to reduce friction. Alternatively, multiple steel balls can be placed between the transmission tube 231 and the conduit body 21 to further reduce friction.

[0079] In this embodiment, the protrusion 2312 is threaded.

[0080] In the embodiment, the plurality of protrusions are arranged, and the coating is arranged on the surface of the protrusions. The protrusions are in contact with the optical fiber through the rubber coating, and the friction between the rubber material and the surface of the optical fiber drives the rotation of the optical fiber.

[0081] Referring to Figure 1 and Figure 4 In the embodiment, the Q-switched thulium laser thrombus ablation device further comprises:

[0082] The infusion assembly 3 comprises an infusion unit 31 and an infusion pipeline 32, and the infusion pipeline 32 is the gap between the protrusions 2312.

[0083] In the embodiment, the infusion assembly 3 is used for conveying normal saline or thrombolytic liquid.

[0084] In the embodiment, the thrombolytic liquid is conveyed through the gap between the protrusions, and the gaps are uniformly and evenly distributed, which is beneficial to the stability of the liquid conveying.

[0085] In the embodiment, the infusion unit comprises an infusion pump. The infusion pump can accurately control the conveying amount of the liquid.

[0086] In the embodiment, the Q-switched thulium laser treatment device has a first working mode and a second working mode.

[0087] In the first working mode, a cavity is arranged between the optical fiber 22 and the end of the catheter body 21 close to the thrombus, and the cavity is in communication with the infusion pipeline 32.

[0088] In the second working mode, the end of the optical fiber 22 and the end of the catheter body 21 close to the thrombus are flush.

[0089] In the embodiment, the position of the optical fiber is accurately controlled by the optical fiber driving assembly, the distance from the thrombus lesion is controlled, and the dominance of the photo-mechanical effect and the photo-acoustic effect is adjusted by the change of the distance. In the photo-mechanical mode (at this time, the photo-thermal mode also exists, and the photo-thermal mode is a secondary mode), the optical fiber is adjusted to be in the catheter, and there is a cavity from the end of the catheter. The normal saline or thrombolytic agent is placed in the catheter, the laser-induced microjet acts on the embolus tissue, the constraint of the catheter cavity can also strengthen the water jet speed, more energy is concentrated in the wave front, and finally the thrombus is broken; in the photo-thermal mode, the optical fiber is flush with the end of the catheter, directly acts on the embolus position, and realizes accurate thermal ablation. For a relatively thin blood vessel region, the optical fiber can be independently extended to the outside of the catheter to be close to the target tissue.

[0090] Referring to Figure 3 In the embodiment, the Q-switched thulium laser thrombus ablation device further comprises:

[0091] The expansion assembly 4 comprises an expansion member driving unit 41 and an expansion member 42, the expansion member 42 is arranged outside the catheter body 21, and the expansion member driving unit 41 is used to drive the expansion member 42 to expand or contract.

[0092] In the embodiment, the expansion member driving unit 41 can be a liquid delivery device or a gas delivery device. The present disclosure does not limit this.

[0093] In the embodiment, the expansion member 42 is an expansion balloon.

[0094] In the embodiment, a delivery pipeline 43 is further arranged between the expansion member driving unit 41 and the expansion member 42.

[0095] In the embodiment, the expansion assembly is arranged, and the blood vessel can be directly expanded without starting the laser for slight embolism, so as to eliminate the blockage. In the state of starting the laser, the balloon can expand the diameter of the blood vessel, increase the safe working space of the device, and avoid the problem of the blood vessel wall being narrowed by heat in the temperature rising process of the laser work.

[0096] Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present application, and not to limit them; although the present application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that: it can still modify the technical solutions recorded in the foregoing embodiments, or make equivalent replacement for part of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present application.

Claims

1. A Q-switched thulium laser thrombus ablation device, characterized in that, The application relates to a Q-switched thulium laser thrombus ablation device. The Q-switched thulium laser thrombus ablation device comprises a Q-switched thulium laser generating assembly for generating Q-switched thulium laser, a catheter body, an optical fiber and an optical fiber driving assembly. The optical fiber is arranged in the catheter body and is used for obtaining the Q-switched thulium laser and emitting the Q-switched thulium laser towards a thrombus in a blood vessel. The optical fiber driving assembly comprises a transmission member arranged between the catheter body and the optical fiber and in transmission connection with the optical fiber, and one end of the transmission member extends to the outside of the catheter body and is in transmission connection with the optical fiber driving unit. The Q-switched thulium laser thrombus ablation device has a first working mode and a second working mode. In the first working mode, a cavity is arranged between the optical fiber and the end of the catheter body close to the thrombus. In the second working mode, the end of the optical fiber is flush with the end of the catheter body close to the thrombus or the optical fiber alone extends to the outside of the catheter and is close to the thrombus. The position of the optical fiber is controlled by the optical fiber driving assembly to control the distance from the thrombus, and the dominance of the photo-mechanical effect and the photo-thermal effect is adjusted by the distance change; in the photo-mechanical mode, the optical fiber is adjusted to the inside of the catheter, a cavity is arranged between the end of the catheter and the optical fiber, and the laser-induced microjet is used for the thrombus; in the photo-thermal mode, the end of the optical fiber is flush with the end of the catheter or the optical fiber alone extends to the outside of the catheter and is close to the thrombus, and the thermal ablation is realized. The pulse width of the Q-switched thulium laser is 30-1000 ns.

2. The Q-switched thulium laser thrombus ablation device of claim 1, wherein, The repetition frequency of the Q-switched thulium laser is 200 Hz-200 kHz.

3. The Q-switched thulium laser thrombus ablation device of claim 1, wherein, The average power of the Q-switched thulium laser is 0-30 W.

4. The Q-switched thulium laser thrombus ablation device of claim 1, wherein, The diameter of the optical fiber is 50-600 mu m.

5. The Q-switched thulium laser thrombus ablation device of claim 1, wherein, The Q-switched thulium laser generating assembly adopts a master oscillator power amplifier structure and comprises a seed light generating assembly and a laser amplification assembly which are sequentially connected through a thulium-doped optical fiber.

6. The Q-switched thulium laser thrombus ablation device according to any one of claims 1 to 5, characterized in that, The seed light generating assembly is used for generating seed light of thulium laser and comprises a first grating, a second grating, an acousto-optic modulation device arranged between the first grating and the second grating, a first laser and a first pump light stripping unit arranged between the acousto-optic modulation device and the first laser, and a first laser isolation unit arranged behind the second grating and used for controlling the one-way transmission of the seed light. The laser amplification assembly is used for amplifying the seed light to form thulium laser meeting the requirements and comprises a plurality of second lasers, a second pump light stripping unit and a second laser isolation unit which are coupled with the thulium-doped optical fiber and are used for controlling the one-way transmission of the thulium laser. The optical fiber driving unit comprises a driving motor, the transmission member is a transmission pipe, the inner surface of the transmission pipe is provided with a plurality of convex portions, the surface of the convex portions is covered with a coating, and the coating comprises a rubber coating. The Q-switched thulium laser thrombus ablation device further comprises a transfusion assembly which comprises a transfusion unit and a transfusion pipeline, and the transfusion pipeline is a gap between the convex portions. The cavity is in communication with the transfusion pipeline.

7. The Q-switched thulium laser thrombus ablation device according to any one of claims 1 to 5, characterized in that, The Q-switched thulium laser thrombus ablation device further comprises an expansion assembly which comprises an expansion member driving unit and an expansion member, the expansion member is arranged outside the catheter body, and the expansion member driving unit is used for driving the expansion member to expand or contract.

8. The Q-switched thulium laser thrombus ablation device of claim 7, wherein, ​ ​ 9. The Q-switched thulium laser thrombus ablation device of claim 8, wherein, ​ 10. The Q-switched thulium laser thrombus ablation device according to any one of claims 1 to 5, characterized in that, ​ ​

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