Caulis spatholobi whitening and skin care emulsion
By combining plant extracts and chemical ingredients such as chicken blood vine, cinnamon, and Centella asiatica, a chicken blood vine whitening skin care lotion was developed, which solved the skin irritation problems caused by chemical ingredients in existing whitening products and improved the whitening effect and product stability.
Patent Information
- Application Number
- CN202411978029.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-31
- Publication Date
- 2025-03-25
AI Technical Summary
The reliance on chemical ingredients of existing skin care products may cause skin irritation and allergies, and the whitening effect of using chicken blood vine extract is limited, making it difficult to meet the requirements of modern skin care products for stability and usage.
Combining plant extracts such as chicken blood vine, cinnamon, and Centella asiatica, as well as chemical ingredients such as propylene glycol, triethanolamine, moisturizer, emulsifier, carboxymethylcellulose sodium, we develop a chicken blood vine whitening skin care lotion to enhance the whitening effect and reduce the use of chemical ingredients.
It has achieved multiple effects such as whitening, moisturizing, antibacterial and stability, improving the safety and use of the product, and reducing the risks of skin irritation and allergies.
Smart Images
Figure SMS_1 
Figure SMS_2 
Figure SMS_3
Abstract
Description
Technical Field
[0001] The present invention relates to the field of skin care products, and more specifically to a Millettia spatholobi whitening skin care lotion. Background Art
[0002] In the field of skin care, with the growing demand of consumers for whitening and skin care, various skin care products with whitening effects have emerged on the market. However, many traditional whitening products rely on chemical ingredients such as hydroquinone to achieve whitening effects, but these ingredients may cause side effects such as skin irritation and allergies. Therefore, it is particularly important to develop a safe, effective and natural whitening skin care product.
[0003] As a traditional Chinese medicinal material, Millettia reticulata has the effects of promoting blood circulation and replenishing blood, relaxing muscles and activating collaterals, and has gradually attracted attention in the field of skin care in recent years. Studies have shown that Millettia reticulata contains a variety of ingredients that are beneficial to the skin, such as flavonoids and polysaccharides. These ingredients have antioxidant, anti-inflammatory and whitening effects, can improve uneven skin tone, reduce spots, and promote skin metabolism.
[0004] However, using Millettia spatholobi extract alone as a whitening ingredient may have limited effects and is difficult to meet the requirements of modern skin care products for stability and user experience. Therefore, it is necessary to combine other plant extracts and chemical ingredients to optimize the formula and improve the whitening effect and skin care performance of the product. Summary of the invention
[0005] An object of the present invention is to solve at least the above problems and to provide at least the advantages which will be described hereinafter.
[0006] Another object of the present invention is to provide a Millettia reticulata whitening skin care lotion, which combines the synergistic effects of cinnamon and Centella asiatica to improve the whitening effect of the product, while reducing the use of chemical synthetic ingredients and reducing the irritation and allergy of the product to the skin.
[0007] In order to achieve these purposes and other advantages according to the present invention, a Millettia spatholobi whitening skin care lotion is provided, which is composed of the following components: Millettia spatholobi, cinnamon, Centella asiatica, propylene glycol, triethanolamine, moisturizer, emulsifier, sodium carboxymethyl cellulose, Jermak BP, disodium EDTA, essence, vitamin B5 and deionized water.
[0008] Preferably, it is composed of the following components in parts by mass: 1-10 parts of Millettia spatholobi, 0.5-5 parts of cinnamon, 0.5-5 parts of Centella asiatica, 3-8 parts of propylene glycol, 0.5-0.8 parts of triethanolamine, 0.1-0.15 parts of moisturizer, 1-1.5 parts of emulsifier, 1-1.5 parts of sodium carboxymethyl cellulose, 0.01-0.1 parts of Jemma BP, 0.02-0.04 parts of disodium EDTA, 0.1-0.15 parts of flavor, 0.5-1 parts of vitamin B5 and 100 parts of deionized water.
[0009] Preferably, it is composed of the following components in parts by mass: 4 parts of Millettia spatholobi, 1 part of cinnamon, 1 part of Centella asiatica, 5 parts of propylene glycol, 0.5 parts of triethanolamine, 0.12 parts of moisturizer, 1.2 parts of emulsifier, 1.2 parts of sodium carboxymethyl cellulose, 0.02 parts of Jemma BP, 0.03 parts of disodium EDTA, 0.12 parts of flavor, 0.8 parts of vitamin B5 and 100 parts of deionized water.
[0010] Preferably, the moisturizing agent is one of sodium hyaluronate, trehalose, sorbitol and glycerin.
[0011] Preferably, the emulsifier is one of stearic acid soap, polyacrylamide and lauryl alcohol.
[0012] Preferably, the mixture further comprises 2 to 4 parts by weight of Momordica grosvenori volatile oil.
[0013] Preferably, the preparation method of the monk fruit volatile oil is: mixing monk fruit with deionized water and stirring evenly, first ultrasonicating for 20 to 30 minutes, then adding cellulase for enzymolysis for 20 minutes, heating to 100°C, and refluxing at 100°C for 7 to 8 hours to obtain a mixed solution, extracting the mixed solution with ether and then distilling off the ether to obtain the volatile oil; wherein the mass ratio of the monk fruit to the deionized water is 1:5 to 8.
[0014] Preferably, it is prepared by the following steps: S1. Divide deionized water into four parts, namely, a first part with 40 parts by weight, a second part with 15 parts by weight, a third part with 30 parts by weight, and the remainder is a fourth part; S2, mixing sodium carboxymethyl cellulose, a moisturizing agent and the first portion of deionized water, stirring and mixing at 75-80° C. to form a first mixture; S3, mixing the emulsifier with the second portion of deionized water, stirring and emulsifying at 75-80° C. for 15 min, adding disodium EDTA and homogenizing to form a second mixture; S4. Add the residue after extracting volatile oil from cinnamon bark, Millettia spatholobi, and Centella asiatica into an extraction container, add 20 times the amount of deionized water as the medicinal material, boil for 2 h, filter, add 10 times the amount of water as the medicinal material to the residue, boil for 1.5 h, filter, combine the filtrate and concentrate into a paste to obtain a concentrate, add triethanolamine, Jermak BP, the third portion of deionized water, and propylene glycol to the concentrate, stir and mix evenly to form a third mixture; S5, stirring and mixing the vitamin B5, the essence and the fourth portion of deionized water to form a fourth mixture; S6. Evenly mix and homogenize the first mixture, the second mixture, the third mixture, the fourth mixture and propylene glycol to obtain Millettia spatholobi whitening skin care lotion.
[0015] The present invention has at least the following beneficial effects: First, the present invention proposes a formula of a whitening skin care lotion of Millettia spatholobi, which uses Millettia spatholobi as the main active ingredient, combines plant extracts such as cinnamon and Centella asiatica, and chemical ingredients such as propylene glycol, triethanolamine, moisturizer, emulsifier, and sodium carboxymethyl cellulose, aiming to achieve multiple functions such as whitening, moisturizing, antibacterial and stabilization. Among them, cinnamon and Centella asiatica have anti-inflammatory, antioxidant and skin-soothing effects, which can enhance the whitening effect of Millettia spatholobi; propylene glycol and triethanolamine are used as moisturizers and emulsifiers to help improve the use experience of the product; sodium carboxymethyl cellulose is used as a thickener to increase the stability of the product; Jema BP is used as a preservative to extend the shelf life of the product; disodium EDTA is used as a chelating agent to prevent metal ions from damaging the stability of the product; vitamin B5 has the effect of moisturizing and repairing the skin, which can further enhance the skin care performance of the product. Second, the formula of the whitening skin care lotion of Millettia spatholobi proposed in the present invention aims to combine the advantages of traditional Chinese medicinal materials and modern chemical ingredients to develop a safe, effective and natural whitening skin care product to meet the diverse needs of consumers for whitening and skin care. Third, the emulsion prepared by adding Millettia spatholobi in the present invention is natural in origin, safe to use, has certain anti-irritation and skin repair effects, and also has certain anti-inflammatory effects; by adding monk fruit volatile oil, the anti-inflammatory, anti-irritation and skin repair effects of the skin care lotion can be further improved.
[0016] Other advantages, objectives and features of the present invention will be embodied in part through the following description, and in part will be understood by those skilled in the art through study and practice of the present invention. DETAILED DESCRIPTION
[0017] The present invention is described in further detail below so that those skilled in the art can implement it according to the description.
[0018] It should be understood that the terms such as “having”, “including” and “comprising” used herein do not exclude the existence or addition of one or more other elements or combinations thereof.
[0019] It should be noted that the experimental methods described in the following embodiments are conventional methods unless otherwise specified, and the reagents and materials can be obtained from commercial channels unless otherwise specified.
[0020] <Example 1> A Millettia spatholobi whitening skin care lotion is composed of the following components in parts by mass: 4 parts of Millettia spatholobi, 1 part of cinnamon, 1 part of Centella asiatica, 5 parts of propylene glycol, 0.5 parts of triethanolamine, 0.12 parts of sodium hyaluronate, 1.2 parts of lauryl alcohol, 1.2 parts of sodium carboxymethyl cellulose, 0.02 parts of Jemma BP, 0.03 parts of disodium EDTA, 0.12 parts of jasmine essence, 0.8 parts of vitamin B5 and 100 parts of deionized water.
[0021] The skin care lotion is prepared by the following steps: S1. Divide deionized water into four parts, namely, a first part with 40 parts by weight, a second part with 15 parts by weight, a third part with 30 parts by weight, and the remainder is a fourth part; S2, mixing sodium carboxymethyl cellulose, a moisturizing agent and the first portion of deionized water, stirring and mixing at 75-80° C. to form a first mixture; S3, mixing the emulsifier with the second portion of deionized water, stirring and emulsifying at 75-80° C. for 15 min, adding disodium EDTA and homogenizing to form a second mixture; S4. Add the residue after extracting volatile oil from cinnamon bark, Millettia spatholobi, and Centella asiatica into an extraction container, add 20 times the amount of deionized water as the medicinal material, boil for 2 h, filter, add 10 times the amount of water as the medicinal material to the residue, boil for 1.5 h, filter, combine the filtrate and concentrate into a paste to obtain a concentrate, add triethanolamine, Jermak BP, the third portion of deionized water, and propylene glycol to the concentrate, stir and mix evenly to form a third mixture; S5, stirring and mixing the vitamin B5, the essence and the fourth portion of deionized water to form a fourth mixture; S6. Evenly mix and homogenize the first mixture, the second mixture, the third mixture, the fourth mixture and propylene glycol to obtain Millettia spatholobi whitening skin care lotion.
[0022] <Example 2> A Millettia spatholobi whitening skin care lotion is composed of the following components in parts by mass: 4 parts of Millettia spatholobi, 1 part of cinnamon, 1 part of Centella asiatica, 3 parts of Momordica grosvenori volatile oil, 5 parts of propylene glycol, 0.5 parts of triethanolamine, 0.12 parts of sodium hyaluronate, 1.2 parts of lauryl alcohol, 1.2 parts of sodium carboxymethyl cellulose, 0.02 parts of Jemma BP, 0.03 parts of disodium EDTA, 0.12 parts of essence, 0.8 parts of vitamin B5 and 100 parts of deionized water.
[0023] The skin care lotion is prepared by the following steps: S1. Divide deionized water into four parts, namely, a first part with 40 parts by weight, a second part with 15 parts by weight, a third part with 30 parts by weight, and the remainder is a fourth part; S2, mixing sodium carboxymethyl cellulose, a moisturizing agent and the first portion of deionized water, stirring and mixing at 75-80° C. to form a first mixture; S3, mixing lauryl alcohol with the second portion of deionized water, stirring and emulsifying at 80° C. for 15 min, adding monk fruit volatile oil and disodium EDTA and homogenizing to form a second mixture; S4. Add the residue after extracting volatile oil from cinnamon bark, Millettia spatholobi, and Centella asiatica into an extraction container, add 20 times the amount of deionized water as the medicinal material, boil for 2 h, filter, add 10 times the amount of water as the medicinal material to the residue, boil for 1.5 h, filter, combine the filtrate and concentrate into a paste to obtain a concentrate, add triethanolamine, Jermak BP, the third portion of deionized water, and propylene glycol to the concentrate, stir and mix evenly to form a third mixture; S5, stirring and mixing the vitamin B5, the essence and the fourth portion of deionized water to form a fourth mixture; S6. Evenly mix and homogenize the first mixture, the second mixture, the third mixture, the fourth mixture and propylene glycol to obtain Millettia spatholobi whitening skin care lotion.
[0024] The preparation method of the monk fruit volatile oil is as follows: mixing monk fruit with deionized water and stirring evenly, placing the monk fruit in an ultrasonic environment with an ultrasonic frequency of 40 Hz for 30 minutes, then adding cellulase, adjusting the pH to 5.0, placing the mixture at 55°C for 20 minutes for enzymolysis, heating it to 100°C, and refluxing it at 100°C for 8 hours to obtain a mixed solution, wherein the mixed solution is an oil-water mixed solution, extracting the oil-water mixed solution with ether, then removing the ether by rotary evaporation to obtain the volatile oil, the mass ratio of the monk fruit to the deionized water is 1:8; the mass ratio of the monk fruit to the cellulase is 1:0.02.
[0025] <Comparative Example 1> The difference between Comparative Example 1 and Example 1 is that in Comparative Example 1, cinnamon bark, Millettia spatholobi and Centella asiatica are directly added into the extraction container for extraction, and the rest is the same as Example 1.
[0026] <Comparative Example 2> The difference between Comparative Example 2 and Example 1 is that the residue after extracting volatile oil from cinnamon bark and Centella asiatica are not added to Comparative Example 2, that is, only Millettia spatholobi is included, and the rest is the same as Example 1.
[0027] <Acute skin irritation test> Method: The acute skin irritation test was conducted with reference to the Technical Specifications for Safety of Cosmetics (2021) with adaptive modifications, as follows: Select 2.4-2.6kg rabbits, half male and half female, and remove the hair on both sides of their backs 24 hours before the test without damaging the skin. The area of hair removal on each side is about 2cm×2cm. Take about 0.5g of the test substance and apply it on one side of the skin, then cover it with gauze and fix it with non-irritating adhesive tape. The skin on the other side is a blank control. Remove the residual test substance with warm water 6 hours after application. 2 hours after removing the test substance, observe whether the skin on the back of the rabbit is erythematous and edema. According to the degree of erythema and edema, score it according to Table 1, and take the average score of 10 groups of tests as the final score. Collect the final score and compare it with Table 2 to grade the irritation of the test substance to the skin. Among them, the average score = (total score of erythema and eschar formation + total score of edema formation) / total number of animals.
[0028] Table 1 Scoring criteria for skin symptom reactions Table 2 Evaluation criteria for skin irritation intensity Sample: Take the skin care lotions in Examples 1-2 and Comparative Examples 1-2 as test objects, conduct acute skin irritation test, and record the skin irritation intensity of each test object according to Table 2. The specific results are shown in Table 3.
[0029] Table 3 Acute skin irritation test results of each embodiment and comparative example As can be seen from Table 3, when cinnamon is used to prepare skin care lotion without removing volatile oil, it is mildly irritating to the skin. The skin care lotion prepared by using the residue after extracting volatile oil from cinnamon is mild and non-irritating to the skin and is relatively safe to use.
[0030] <Effects of xylene on ear swelling in mice> Methods: Take 6 mice weighing 20-22 g, half male and half female, and evenly apply 0.5 g of the test substance on both sides of the right ear of each mouse. After 20 minutes, evenly apply 0.05 ml of xylene on both sides of the right ear of each mouse to induce inflammation. The left ear was not applied as a control. After 30 minutes of xylene application, the mice were killed, and the left and right ears of the mice were cleaned with distilled water and wiped dry. The same area of the left and right ears of the mice was cut off with a 9 mm diameter puncher, and weighed with an electronic balance. The difference in weight between the left and right ear pieces was used as the swelling index to calculate the swelling degree of each experimental group.
[0031] Sample group: The skin care lotions prepared in Example 1, Example 2 and Comparative Example 2 were respectively used as test objects, and the effect of xylene on the swelling of the auricle of mice was tested. The difference in weight between the left and right auricles of the mice was recorded, and the swelling degree was calculated; Blank group: The difference between the mice in the blank group and the mice in the sample group is that the test substance was replaced with 0.5g of normal saline, and the rest was the same; Each group of experiments was tested six times in parallel and the average value was taken. The average values of the experiments of the sample group and the blank group were collected. The specific results are shown in Table 4.
[0032] Table 4 Swelling results of sample group and blank group <Anti-irritation and repair efficacy test> Methods: 30 volunteers aged 20-45 years without immunodeficiency or history of skin disease were selected as subjects and randomly divided into three groups. The ears of the subjects were used as the test site. Three days before the test, no external products or cosmetics were used on the test site. During the test, after the subjects cleaned their ears, 5% sodium lauryl sulfate solution was evenly applied to the test site of each subject, and then 10% lactic acid was applied to the test site of each subject. After 20 minutes of application, the test site of the subjects showed burning, pain, erythema, itching and edema symptoms (proving that the exogenous substances stimulated the skin to form various skin symptoms successfully). Then the test substance was applied to the test site, 0.3g of the test substance was applied per square centimeter of the test site, once in the morning and evening every day, and after 7 consecutive days of application, the degree of disappearance of various skin symptoms in the test site of the subjects was recorded.
[0033] Sample: The skin care lotions prepared in Example 1, Example 2 and Comparative Example 2 were used as test objects. The degree of relief of various skin symptoms at the test sites of the test subjects in each group of tests was recorded. Each group was tested 10 times in parallel and the average value was taken. The specific results are shown in Table 5.
[0034] Table 5 The degree of relief of skin symptoms of the subjects in each experimental group after continuous application of the test substance to the test site for 7 days It can be seen from Table 5 that the skin care lotion prepared in the present application can more effectively relieve various skin symptoms after continuous application for 7 days, and the skin care lotion with added monk fruit volatile oil can further relieve various skin symptoms, indicating that the skin care lotion of the present application has anti-irritation and repair effects.
[0035] <Whitening and Skin Care Effect Color Difference Test> The subjects of the human test were voluntary participants, and the grouping principle was random grouping. The subjects were aged 35-50 years old, had healthy skin, and had no history of cosmetic allergies. There were 3 people in each group, and a total of 5 groups. The skin care lotions prepared in Example 1, Example 2 and Comparative Example 2 were applied to the left and right front wall arm bends of the subjects, once in the morning and evening. The control group was not treated. The color difference of the left and right arms was tested 6 times continuously using a colorimeter 1 day before using the whitening skin care lotion, and after 1 week, 2 weeks, and 3 weeks of use, and the average value was taken.
[0036] The test index uses a colorimeter to measure the color difference ΔL between the left and right arms. A positive ΔL indicates that the left arm is whiter than the right arm, and a negative ΔL indicates that the left arm is darker than the right arm. The results are shown in Table 6.
[0037] Table 6 Changes in ΔL values of each group before and after use As can be seen from Table 6, when Millettia spatholobi is used alone, the whitening effect is not ideal; Millettia spatholobi has a certain whitening effect when used in combination with cinnamon and Centella asiatica; Millettia spatholobi has a better whitening effect when used in combination with cinnamon, Centella asiatica and Momordica grosvenori.
[0038] Although the embodiments of the present invention have been disclosed as above, they are not limited to the applications listed in the specification and the implementation modes. They can be fully applied to various fields suitable for the present invention. For those familiar with the art, additional modifications can be easily implemented. Therefore, without departing from the general concept defined by the claims and the scope of equivalents, the present invention is not limited to specific details.
Claims
1. Millettia reticulata whitening skin care lotion, characterized in that, It is composed of the following components: Millettia spatholobi, cinnamon, Centella asiatica, propylene glycol, triethanolamine, humectant, emulsifier, sodium carboxymethyl cellulose, Jema BP, disodium EDTA, flavor, vitamin B5 and deionized water.
2. The Millettia spatholobi whitening skin care lotion according to claim 1, characterized in that: The invention is composed of the following components in parts by mass: 1-10 parts of Millettia spatholobi, 0.5-5 parts of cinnamon, 0.5-5 parts of Centella asiatica, 3-8 parts of propylene glycol, 0.5-0.8 parts of triethanolamine, 0.1-0.15 parts of moisturizer, 1-1.5 parts of emulsifier, 1-1.5 parts of sodium carboxymethyl cellulose, 0.01-0.1 parts of Jema BP, 0.02-0.04 parts of disodium EDTA, 0.1-0.15 parts of flavor, 0.5-1 parts of vitamin B5 and 100 parts of deionized water.
3. The Millettia spatholobi whitening skin care lotion according to claim 1, characterized in that: The invention is composed of the following components in parts by mass: 4 parts of Millettia spatholobi, 1 part of cinnamon bark, 1 part of Centella asiatica, 5 parts of propylene glycol, 0.5 parts of triethanolamine, 0.12 parts of moisturizer, 1.2 parts of emulsifier, 1.2 parts of sodium carboxymethyl cellulose, 0.02 parts of Jemma BP, 0.03 parts of disodium EDTA, 0.12 parts of flavor, 0.8 parts of vitamin B5 and 100 parts of deionized water.
4. The Millettia spatholobi whitening skin care lotion according to claim 1, characterized in that: The moisturizing agent is one of sodium hyaluronate, trehalose, sorbitol and glycerin.
5. The Millettia spatholobi whitening skin care lotion according to claim 1, characterized in that: The emulsifier is one of stearic acid soap, polyacrylamide and lauryl alcohol.
6. The Millettia spatholobi whitening skin care lotion according to claim 1, characterized in that: The invention also comprises 2 to 4 parts by weight of Momordica grosvenori volatile oil.
7. The Millettia spatholobi whitening skin care lotion according to claim 6, characterized in that: The preparation method of the monk fruit volatile oil is as follows: mixing monk fruit with deionized water and stirring evenly, ultrasonicating for 20 to 30 minutes, adding cellulase for enzymolysis for 20 minutes, heating to 100°C, and refluxing at 100°C for 7 to 8 hours to obtain a mixed solution, extracting the mixed solution with ether, and then distilling off the ether to obtain the volatile oil; wherein the mass ratio of the monk fruit to the deionized water is 1:5 to 8.
8. The Millettia spatholobi whitening skin care lotion according to claim 1, characterized in that: Prepared by the following steps: S1. Divide deionized water into four parts, namely, a first part with 40 parts by weight, a second part with 15 parts by weight, a third part with 30 parts by weight, and the remainder is a fourth part; S2, mixing sodium carboxymethyl cellulose, a moisturizing agent and the first portion of deionized water, stirring and mixing at 75-80° C. to form a first mixture; S3, mixing the emulsifier with the second portion of deionized water, stirring and emulsifying at 75-80° C. for 15 min, adding disodium EDTA and homogenizing to form a second mixture; S4. Add the residue after extracting volatile oil from cinnamon bark, Millettia spatholobi, and Centella asiatica into an extraction container, add 20 times the amount of deionized water as the medicinal material, boil for 2 h, filter, add 10 times the amount of water as the medicinal material to the residue, boil for 1.5 h, filter, combine the filtrate and concentrate into a paste to obtain a concentrate, add triethanolamine, Jermak BP, the third portion of deionized water, and propylene glycol to the concentrate, stir and mix evenly to form a third mixture; S5, stirring and mixing the vitamin B5, the essence and the fourth portion of deionized water to form a fourth mixture; S6. Evenly mix and homogenize the first mixture, the second mixture, the third mixture, the fourth mixture and propylene glycol to obtain Millettia spatholobi whitening skin care lotion.