Traditional Chinese medicine composition for improving oral ulcer and hydrogel

Abstract

The invention discloses a traditional Chinese medicine composition and hydrogel for improving oral ulcer, and the traditional Chinese medicine composition comprises the following components in parts by weight: 10-20 parts of indigo naturalis, 10-25 parts of bletilla striata, 10-20 parts of golden cypress, 10-25 parts of pollen typhae, 10-25 parts of dandelion, 10-25 parts of mint and 10-20 parts of borneol. The hydrogel comprises Bulbophyllum calodictyon Schlecht volatile oil extracted by volatilizing the traditional Chinese medicine composition, and drug-loaded hydrogel. The traditional Chinese medicine composition hydrogel for improving oral ulcer shows excellent water absorption performance, high drug loading capacity and stable chemical properties. When the hydrogel is applied to oral ulcer treatment, the characteristics of the hydrogel are fully exerted, specifically, the hydrogel takes effect quickly, the medicinal duration is long, and adverse reactions such as skin allergy, red and swollen skin and discomfort can be effectively avoided.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and a hydrogel for improving oral ulcers. Background Art

[0002] Oral ulcers are a common oral mucosal disease in clinical practice. They have a high incidence rate and recurrent attacks. They can even affect the patient's diet and sleep, and then seriously affect the patient's mental state, which has a great impact on the patient's quality of life. Western medicine treats this disease with the purpose of eliminating pathogenic factors, alleviating symptoms, shortening the course of the disease, promoting healing, and controlling recurrence. It mainly includes regulating immunity and endocrine, supplementing trace elements and vitamins, and anti-infection. Although it has achieved certain therapeutic effects, glucocorticoids, antibiotics, immune preparations and other drugs are highly dependent, have large toxic and side effects, and the disease is prolonged and unhealed. The recurrence rate is high after stopping the drug, and the patient compliance is poor. Traditional Chinese medicine starts from the overall concept, with the method of clearing heat and detoxifying, cooling blood and reducing swelling, astringing and regenerating muscles, and using both clearing and supplementing, and collecting and dispersing, which makes up for the defect of Western medicine's emphasis on local treatment. However, the difficulty of taking Chinese medicine and the poor taste experience make some patients discouraged. Summary of the invention

[0003] In order to solve the above technical problems, the present invention provides a Chinese medicine composition and hydrogel for improving oral ulcers. The Chinese medicine composition for treating oral ulcers is combined with the hydrogel to prepare a special gel dosage form, which is convenient to use, clean, pollution-free, and highly practical. It can maximize the efficacy of the Chinese medicine composition, is easy for patients to absorb, and has a good therapeutic effect on various oral ulcers.

[0004] On the one hand, the present invention provides a traditional Chinese medicine composition for improving oral ulcers, comprising 10-20 parts by weight of Indigo Naturalis, 10-25 parts of Bletilla striata, 10-20 parts of Phellodendron chinense, 10-25 parts of Pollen Typhae, 10-25 parts of Taraxacum officinale, 10-25 parts of Mentha arvense and 10-20 parts of Borneol.

[0005] Preferably, the weight proportions of Indigo Naturalis, Bletilla striata, Phellodendron amurense, Pollen Typhae, Taraxacum mongolicum, Menthus alba and Borneol in the traditional Chinese medicine composition are all 15 parts.

[0006] On the other hand, the present invention provides a Chinese medicine composition hydrogel for improving oral ulcers, comprising volatile oil of Rhizoma Cynomorii extracted by volatilization from the Chinese medicine composition, and a drug-loaded hydrogel.

[0007] Furthermore, the extraction process of the Qingji volatile oil comprises: placing the traditional Chinese medicine composition in a round-bottom flask, adding 3 to 10 times water and soaking for 1 to 6 hours, and obtaining the Qingji volatile oil by steam distillation.

[0008] Furthermore, the preparation process of the drug-loaded hydrogel includes: preparing 3 to 7 parts of acrylamide, 1 to 3 parts of silk protein, 1 to 3 parts of sodium alginate, 0.01 to 0.1 parts of a cross-linking agent, 10 to 20 parts of tetramethylethylenediamine and 10 to 30 parts of water by weight through a free radical polymerization method, and then crushing them into fine powder particles.

[0009] Preferably, the preparation of the drug-loaded hydrogel comprises taking, by weight, 5 parts of acrylamide, 2 parts of silk protein, 2 parts of sodium alginate, 0.1 parts of a cross-linking agent, 17 parts of tetramethylethylenediamine and 28 parts of water.

[0010] The cross-linking agent is preferably a persulfate, usually potassium persulfate, ammonium persulfate, etc.

[0011] Furthermore, the preparation process of the Chinese medicine composition hydrogel for improving oral ulcers includes mixing the Qingji volatile oil and the drug-loaded hydrogel in a ratio of 1:2 to 1:10, heating and stirring until the mixed solution is in a gel state, pouring the gel solution into a mold, standing to remove bubbles, and then solidifying to obtain the Chinese medicine composition hydrogel for improving oral ulcers.

[0012] Furthermore, the stirring reaction conditions of the Qingji volatile oil and the drug-loaded hydrogel are 90-250 r / min, and the reaction time is 1-2.5 hours.

[0013] The third aspect of the present invention provides a use of the above-mentioned traditional Chinese medicine composition hydrogel in improving oral ulcers.

[0014] The present invention has the following beneficial effects: the Chinese medicine composition hydrogel for improving oral ulcers of the present invention exhibits excellent water absorption performance, high drug loading and stable chemical properties. When the hydrogel is applied to the treatment of oral ulcers, its characteristics are fully exerted, specifically manifested in rapid onset, long duration of medicinal use, and the ability to effectively avoid causing adverse reactions such as skin allergies, redness, swelling and discomfort. The medicinal materials used in the present invention have a wide range of sources and are relatively low in cost. The preparation method thereof is simple and easy, and it is very easy to realize large-scale industrial production. DETAILED DESCRIPTION

[0015] As mentioned in the background technology, among the current methods for treating oral ulcers, Western medicine has great side effects, and the condition is prolonged and unhealed, with a high recurrence rate after discontinuation of medication; Chinese medicine is difficult to take, and the taste experience is poor, all of which have relatively large disadvantages. Therefore, to improve the external dosage form of Chinese medicine treatment, Chinese medicine has the saying that "internal diseases are treated externally, and different paths lead to the same destination", "the principle of external treatment is the principle of internal treatment, and the medicine for external treatment is the medicine for internal treatment, and the difference is the method". The treatment of oral ulcers by Chinese medicine hydrogel has significant efficacy, simple operation and less time consumption, high patient acceptance, good compliance, and solves the problem of poor taste of medication. At the same time, by refining its effective ingredients and optimizing its effects, the development of effective Qingji oral ulcer hydrogel is more suitable and easy to promote.

[0016] Hydrogel is a hydrophilic polymer network system with a unique three-dimensional structure. Its characteristic is that it can absorb water and swell in aqueous solution while remaining insoluble, making it suitable as a drug carrier in the medical field.

[0017] The prescription of the present invention is guided by the holistic concept and dialectical treatment of traditional Chinese medicine. The gel is used as a carrier to apply the medicine directly to the abdomen, and exerts its effect of clearing heat and detoxifying, reducing swelling and relieving pain, thereby promoting the recovery of body functions and achieving the purpose of treatment. In the prescription, Indigo is good at clearing heat and detoxifying, cooling blood and reducing swelling; therefore, it is used as the main medicine. Phellodendron can clear away heat and dampness, and can purge fire and detoxify, and is an important medicine for treating sores, swelling and toxins; Bletilla striata is astringent and hemostatic, and reduces swelling and promotes tissue regeneration; Pollen Typhae is good at dispersing blood stasis and reducing swelling, removing rot and promoting new growth, and astringent and promoting tissue regeneration; the three help the main medicine to cool blood and stop bleeding, reduce swelling and promote tissue regeneration, and are all minister medicines. Taraxacum is used to transform heat and toxicity, resolve food toxicity, disperse stagnant qi, and eliminate carbuncle; peppermint disperses wind and heat, clears the head and eyes, and benefits throat, mouth, teeth, ears and nose diseases. Borneol is used as a messenger to open the mind, clear away heat and relieve pain, and help the medicine reach the diseased area directly, so that the evil is completely dispersed. The combination of these medicines can clear away heat and detoxify, reduce swelling and relieve pain, and astringe and regenerate new tissues, so that ulcers that have not yet formed can be dispersed and those that have already formed can be eliminated. It is clinically suitable for the treatment of oral ulcers. Clinical symptoms include ulcers on the mucous membranes of the lips, cheeks, soft palate or gums of the mouth, generally round or oval, sunken ulcers, white or yellow centers, and slightly red and swollen surrounding areas, with obvious pain. Its efficacy and related pharmacological research are summarized as follows: (1) Indigo: Puji Fang records that it is salty and cold in nature, belongs to the liver meridian, has the effects of clearing away heat and detoxifying, cooling blood and removing spots, and is good at treating wind-heat and fire-toxins that invade the mouth and tongue through the meridians, and tongue ulcers all over the body. Studies have found that Indigo has anti-inflammatory, immune-regulating, antibacterial, antiviral, and analgesic pharmacological effects; Qingbai powder (Indigo and Phellodendron) can significantly accelerate the healing of oral ulcers in model rats, reduce inflammatory reactions and relieve pain; compound Indigo patch can effectively improve the balance of T cell subsets, improve the patient's oral environment, and significantly reduce the area of ​​oral ulcers and hematomas. Indigo can also be taken orally or applied externally to show significant analgesic effects on mice with pain induced by the hot plate method.

[0018] (2) Phellodendron: "Wai Tai Mi Yao" records that it is good at clearing away heat and dampness, purging fire and removing steam, detoxifying and curing sores. It is good at treating oral sores and sore throat caused by wind-heat and virtual fire. The occurrence of ulcers is closely related to oxidative stress, inflammatory response and abnormal immune response. Modern pharmacological studies have found that Phellodendron has anti-ulcer, neuroprotective and antibacterial effects. The total alkaloid component of Phellodendron extract can significantly increase the level of epidermal growth factor in ulcers and accelerate ulcer healing. Dihydroberberine, the active ingredient of Phellodendron, is a natural berberine reduced derivative and intestinal bacterial metabolite. It can significantly relieve auricular edema induced by xylene and paw edema caused by carrageenan, improve vascular permeability induced by acetic acid, and relieve inflammatory cell infiltration in ear and paw tissues. Phellodendron chinense can activate nuclear factor erythroid-2 relatedfactor 2 (Nrf2) and its downstream antioxidant genes to reduce cell apoptosis and oxidative damage, play a synergistic role in inhibiting oxidative stress, and thus promote ulcer healing.

[0019] (3) Bletilla striata: The "Authentic Surgery" records that it is good at promoting tissue regeneration and curing sores, astringing and stopping bleeding, and treating recurrent sores and ulcers that have not healed for a long time. Studies have found that Bletilla striata has antibacterial, antiviral, and wound healing effects. Studies have found that Bletilla striata polysaccharide can accelerate the healing of wounds in rats with deep second-degree burns. The specific mechanism of action may be closely related to the inhibition of the TLR4 / LPS signaling pathway and the expression of downstream inflammatory factors TNF-α and IL-6. Studies have found that a new type of Bletilla striata polysaccharide hydrogel wound dressing can promote the in vivo healing of a full-thickness skin injury model, accelerate wound healing by activating the TGF-β / Smad signaling pathway, promote wound re-epithelialization and collagen deposition, and has good wound healing ability.

[0020] (4) Puhuang: "Shenghui Fang" records that it is good at dispersing blood stasis and swelling, removing rotten flesh and promoting new growth, astringing and promoting muscle growth. It is good at treating recurrent sores and ulcers that have not healed for a long time. Studies have found that Puhuang has the effect of inhibiting inflammation and eliminating edema. Studies have found that the application of Puhuang decoction concentrate to the lower limb scald model rats has a significant swelling effect. In addition, Puhuang can also play an anti-inflammatory role by improving inflammatory genes closely related to insulin resistance, thereby reducing inflammatory reactions. Studies have found that Puhuang solution has a significant analgesic effect and can significantly improve the pain caused by potassium antimony tartrate.

[0021] (5) Dandelion: The "Golden Mirror of Medical Ancestral" records that it is good at transforming heat and toxins, removing food poisons, dispersing stagnant qi, and eliminating carbuncle and swelling. It is good at treating wind-heat invasion and mouth ulcers caused by damp-heat in the spleen and stomach. Studies have found that dandelion has broad-spectrum antibacterial, antioxidant, and anti-inflammatory effects. Its dandelion extract has significant inhibitory effects on Staphylococcus aureus, hemolytic Streptococcus, Staphylococcus epidermidis, and Catarrhalis. In addition, dandelion can regulate immunity and restore the immune function of scalded mice, including cell-mediated immunity, humoral immunity, and nonspecific immunity, and it is dose-dependent.

[0022] (6) Peppermint: "Treatise on Warm Diseases" records that it can dissipate wind and heat, clear the head and eyes, and benefit the throat, mouth, teeth, ears and nose diseases. It is good at treating swelling and pain caused by mouth sores. Modern pharmacological studies have found that peppermint has anti-inflammatory, antibacterial, antiviral, analgesic, and antioxidant effects. A study found that peppermint oil exerts an anti-herpes simplex virus (HSV)-1 and HSV-2 subtype effects by inhibiting reverse transcriptase, showing a significant time correlation. In addition, the ethanol extract, menthol and piperonene in peppermint have a significant analgesic effect. Peppermint volatile oil, menthol and monoterpenes and other compounds have strong antibacterial activity and have a certain synergistic effect.

[0023] (7) Borneol: The New Compendium of Materia Medica records that it can invigorate the mind, clear away heat and relieve pain, and is good at treating various sores. Studies have found that borneol can help drugs pass through the body's barriers, and borneol is often used as an adjuvant in Chinese medicine compatibility to help other drugs better exert their therapeutic effects. There is a saying that "it is weak when used alone, but it is effective when used as an adjuvant." In addition, borneol also has analgesic and anti-inflammatory effects. Studies have found that after the use of borneol, the pain and closure values ​​of mice in the burn-induced wound model were significantly increased. At the same time, borneol also has anti-inflammatory and antibacterial effects.

[0024] In order to enable those skilled in the art to better understand the solution of the present application, the technical solution in the embodiment of the present application will be clearly and completely described below in combination with the embodiment of the present application. Obviously, the described embodiment is only a part of the embodiment of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in the field without creative work should fall within the scope of protection of the present application.

[0025] Example 1: Chinese medicine composition for improving oral ulcers The present embodiment provides a traditional Chinese medicine composition for improving oral ulcers, comprising 10-20 parts of Indigo Naturalis, 10-25 parts of Bletilla striata, 10-20 parts of Phellodendron amurense, 10-25 parts of Pollen Typhae, 10-25 parts of Taraxacum officinale, 10-25 parts of Mentha arvense, and 10-20 parts of Borneol by weight.

[0026] Preferably, the weight proportions of Indigo Naturalis, Bletilla striata, Phellodendron amurense, Pollen Typhae, Taraxacum mongolicum, Menthus alba and Borneol in the traditional Chinese medicine composition are all 15 parts.

[0027] Example 2: Traditional Chinese medicine composition hydrogel for improving oral ulcers This embodiment provides a traditional Chinese medicine composition hydrogel for improving oral ulcers, comprising volatile oil of Rhizoma Cynomorii extracted by volatilization from the traditional Chinese medicine composition, and a drug-loaded hydrogel.

[0028] The extraction process of the volatile oil of Qingji comprises: placing the traditional Chinese medicine composition in a round-bottom flask, adding 3-10 times water to soak for 1-6 hours, and obtaining the volatile oil of Qingji by steam distillation.

[0029] The preparation process of the drug-loaded hydrogel comprises: preparing 3-7 parts of acrylamide, 1-3 parts of silk protein, 1-3 parts of sodium alginate, 0.01-0.1 parts of a cross-linking agent, 10-20 parts of tetramethylethylenediamine and 10-30 parts of water by weight through a free radical polymerization method, and then crushing into fine powder particles.

[0030] The preparation process of the Chinese medicine composition hydrogel for improving oral ulcers comprises the following steps: mixing the Qingji volatile oil and the drug-loaded hydrogel in a ratio of 1:2 to 1:10, heating and stirring until the mixed solution is in a gel state, pouring the gel solution into a mold, standing it to remove bubbles, and then solidifying and shaping it to obtain the Chinese medicine composition hydrogel for improving oral ulcers.

[0031] The stirring reaction conditions of the Qingji volatile oil and the drug-loaded hydrogel are 90-250 r / min, and the reaction time is 1-2.5 hours.

[0032] Experimental Example 1 Oral ulcer animal model experiment 1. Experimental animals: 18 male Sprague Dawley rats weighing 150-180 g were selected.

[0033] 2. Experimental materials: hydrogel preparations prepared according to the claims.

[0034] 3. Experimental groups: 60 rats were randomly divided into 5 experimental groups, namely blank group (n=12), model group (n=12), low-dose hydrogel group (n=12), medium-dose hydrogel group (n=12), and high-dose hydrogel group (n=12).

[0035] 4. Model establishment: The rats were adaptively fed for 3 days. Rats were anesthetized with 1% sodium pentobarbital (0.4-0.5 mL / 100 g), and the mouths were fixed with a simple mouth opener to fully expose the buccal mucosa on both sides. A circular filter paper with a diameter of 5 mm was cut, and the filter paper was soaked with 50% glacial acetic acid for 5 seconds, and then quickly pressed on the buccal mucosa on both sides for 40 seconds. The excess glacial acetic acid was wiped off with a cotton swab dipped in saline, and the mucosa at the pressed part of the rat was observed to be damaged and turned bright red. After 24 hours, the model was successfully established if local redness, swelling, and ulceration were observed at the treated part of the buccal mucosa.

[0036] 5. Clinical evaluation of oral ulcers in rats: Photos of rat ulcers were taken every day starting from D1. The calibrated periodontal probe was placed at the edge of the ulcer as a control when taking photos. Each photo was analyzed using image analysis software (Image J). The ulcer area was measured by visual inspection and macroscopic quantitative analysis. The degree of ulcer healing was calculated according to the following formula: ulcer healing degree = (A1-An) / A1×100%, where A1 is the ulcer area on D1 day, and An is the unhealed ulcer area every other day after D1 day.

[0037] 6. Histological evaluation of oral ulcers in rats: Six sites were randomly selected for sampling on the third and fifth days after modeling in each group, and the mucosal tissues of three sites were immediately fixed with 10% formaldehyde at room temperature for 24 h. The specimens were then embedded in paraffin, fixed, sliced, and placed on slides for HE staining. Five fields of view were selected from each slide and photographed at 100× magnification to observe the number of inflammatory cells and new blood vessels.

[0038] 7. Experimental Results

[0039] The results show that the Chinese medicine compositions provided by the present invention all have the effect of treating ulcers, and the high-dose group has the best effect.

[0040] Experimental Example 2 Clinical effectiveness experiment Take 15 parts of Indigo Naturalis, 15 parts of Bletilla striata, 15 parts of Phellodendron chinense, 15 parts of Pollen Typhae, 15 parts of Taraxacum Herba, 15 parts of Mentha arvense, and 15 parts of Borneol to make a hydrogel preparation for clinical trials to preliminarily test the safety and efficacy of the drug.

[0041] All 20 cases were outpatients from March 2019 to August 2023. They ranged in age from 16 to 40 years old, with an average age of 26 years old, and 21 cases of oral ulcers. There were 22 people in the control group (retrospective cases), ranging in age from 18 to 38 years old, with an average age of 27 years old, and 23 cases of oral ulcers.

[0042] 1. Treatment methods: Control group: Apply Qingji gel patch externally once a day for 7 consecutive days as a course of treatment.

[0043] Treatment group: Apply propolis patch externally, once a day, for 7 consecutive days as a course of treatment.

[0044] 2. Efficacy judgment criteria: The oral ulcer conditions of both groups of subjects were observed after one course of treatment.

[0045] Recovery: Clinical symptoms disappear.

[0046] Marked effect: The ulcers were dispersed to 1-2 points, and the pain, redness and swelling symptoms disappeared.

[0047] Effective: Scattered ulcer spots can be seen in the mouth, and the symptoms of pain, redness and swelling are significantly improved.

[0048] Ineffective: No improvement in clinical symptoms.

[0049] Comparison of the overall efficacy between the two groups:

[0050] The results showed that the treatment group had better efficacy than the control group.

[0051] 3. Comparison of relapse rates between the two groups: After 3 months, the cured cases in the treatment group and the control group were selected for relapse rate investigation. There were 5 relapses in the control group, with a relapse rate of 5 / 8; there were 2 relapses in the treatment group, with a relapse rate of 2 / 16. The relapse rate in the treatment group was lower than that in the control group.

[0052] Experimental Example 3 Clinical Case The clinical trial results are as follows: the present invention is an external medicine, and a total of 5,000 patients with oral ulcers were treated, with a cure rate of 96% and a marked efficacy of 91%.

[0053] The following are 3 clinical cases: 1. Zhang, female, 5 years old, visited the hospital on February 16, 2024. Chief complaint: oral ulcers for 2 weeks. The patient had recurrent oral ulcers without obvious causes 2 weeks ago. There were ulcers on the oral mucosa and tongue, unbearable pain, poor appetite, reduced food intake, accompanied by drooling from the corners of the mouth, irritability, sweating, normal bowel movements, red tongue with yellow greasy coating, and slippery pulse. Western medicine diagnosis: oral ulcers; Chinese medicine diagnosis: oral ulcers (stomach fire inflammation), treatment: clearing heat and eliminating sores, cooling blood and reducing swelling, astringing and regenerating muscles. The child had difficulty taking medicine and vomited as soon as he ate. The family members requested external treatment with drugs, so they gave Qingji oral gel 6 patches, 2 patches per day. Telephone follow-up on February 20, 2024: After the child applied it externally for 1 day, the pain, crying and restlessness were significantly relieved. After continuing the external treatment, the child's oral ulcers gradually subsided.

[0054] 2. Chen, male, 22 years old. Oral ulcers recurred for more than 2 months and worsened for 1 week. The patient complained that he had repeated ulcer pain in his mouth after fatigue 2 months ago, which affected his eating and sleeping. After taking vitamin B2 and vitamin C tablets on his own, the symptoms did not improve significantly and he did not pay attention to it. One week ago, ulcers appeared in his mouth again, with burning pain. For further diagnosis and treatment, he came to our hospital for treatment. Current symptoms: The patient had 3 ulcers in his mouth, scattered on the tip of the tongue, lower lip, and left gums. The ulcer surface was 2-4mm in diameter, with a sunken center, clear borders, and a red halo around it. The surface was covered with a gray-white pseudomembrane, and the burning pain was obvious. The complexion was sallow, fatigued, poor appetite, abdominal distension after eating, poor sleep, loose stools, one line a day, and regular urination. The tongue was pale red, with a thin white fur, tooth marks on the edges, and a stringy and thin pulse. Western medicine diagnosis: recurrent oral ulcers (mild), Chinese medicine diagnosis: oral ulcers (deficient fire inflammation syndrome). Syndrome differentiation analysis: According to the patient's clinical manifestations (yellow, red, concave, painful) and medical history characteristics (small oral ulcers, few in number, short onset time, no systemic symptoms and scar formation), it can be diagnosed as recurrent oral ulcers (mild). Oral ulcers are caused by the fumigation of real heat in the upper part of the body, abnormal ascending and descending of the middle part of the body, and the inflammation of virtual fire in the lower part of the body, which spreads through all meridians. They should be treated separately. In addition, the patient often travels on business and travels to many places, so the Qingji oral ulcer gel is applied externally. After 3 days of external application, the ulcers of the patient subsided and the pain was relieved. After continuing to use the medication, the oral ulcers completely subsided.

[0055] 3. He Moumou, male, 16 years old, first visit on October 3, 2020. Main complaint: "oral ulcer pain for 1 week." With low fever, body temperature continued to be between 37.4 and 38.6 degrees, fever was obvious at night, oral amoxicillin clavulanate potassium treatment was not effective, sometimes there was pain in the mouth ulcer, no appetite, sticky and uncomfortable stool; red tongue, slightly yellow and greasy fur, slippery pulse. There was no obvious abnormality in the blood routine. Chinese medicine diagnosis: oral ulcer (damp heat obstruction). Treatment: clear heat and dampness, detoxify and heal ulcers. Apply external Qingji oral ulcer hydrogel. After the child applied Qingji oral ulcer powder for 7 patches, the mouth ulcer did not appear, appetite increased and bowel movements were smooth.

[0056] The above description is only the preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A Chinese medicine composition for improving oral ulcers, characterized in that: The invention comprises 10-20 parts of Indigo Naturalis, 10-25 parts of Bletilla striata, 10-20 parts of Phellodendron amurense, 10-25 parts of Pollen Typhae, 10-25 parts of Taraxacum officinale, 10-25 parts of Mentha arvense and 10-20 parts of Borneol by weight.

2. The Chinese medicine composition for improving oral ulcers according to claim 1, characterized in that: The weight proportions of Indigo Naturalis, Bletilla striata, Phellodendron amurense, Pollen Typhae, Taraxacum mongolicum, Mentha arborvitae and Borneol in the traditional Chinese medicine composition are all 15 parts.

3. A Chinese medicine composition hydrogel for improving oral ulcers, characterized in that: The invention comprises the volatile oil of Rhizoma Cibotii extracted by volatilization from the traditional Chinese medicine composition according to claim 1, and the drug-carrying hydrogel.

4. The Chinese medicine composition hydrogel for improving oral ulcers according to claim 3, characterized in that: The extraction process of the volatile oil of Qingji comprises: placing the traditional Chinese medicine composition in a round-bottom flask, adding 3-10 times water to soak for 1-6 hours, and obtaining the volatile oil of Qingji by steam distillation.

5. The Chinese medicine composition hydrogel for improving oral ulcers according to claim 3, characterized in that: The preparation process of the drug-loaded hydrogel comprises: preparing 3-7 parts of acrylamide, 1-3 parts of silk protein, 1-3 parts of sodium alginate, 0.01-0.1 parts of a cross-linking agent, 10-20 parts of tetramethylethylenediamine and 10-30 parts of water by weight through a free radical polymerization method, and then crushing into fine powder particles.

6. The Chinese medicine composition hydrogel for improving oral ulcers according to claim 5, characterized in that: The preparation of the drug-loaded hydrogel comprises taking, by weight, 5 parts of acrylamide, 2 parts of silk protein, 2 parts of sodium alginate, 0.1 parts of a cross-linking agent, 17 parts of tetramethylethylenediamine and 28 parts of water.

7. The Chinese medicine composition hydrogel for improving oral ulcers according to claim 5 or 6, characterized in that: The cross-linking agent is persulfate.

8. The Chinese medicine composition hydrogel for improving oral ulcers according to any one of claims 3 to 6, characterized in that: The preparation process of the Chinese medicine composition hydrogel for improving oral ulcers comprises the following steps: mixing the Qingji volatile oil and the drug-loaded hydrogel in a ratio of 1:2 to 1:10, heating and stirring until the mixed solution is in a gel state, pouring the gel solution into a mold, standing it to remove bubbles, and then solidifying and shaping it to obtain the Chinese medicine composition hydrogel for improving oral ulcers.

9. The Chinese medicine composition hydrogel for improving oral ulcers according to claim 8, characterized in that: The stirring reaction conditions of the volatile oil of Qingji and the drug-loaded hydrogel are 90-250 r / min, and the reaction time is 1-2.5 hours.

10. Use of the Chinese medicine composition hydrogel according to any one of claims 3 to 9 in improving oral ulcers.

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