Preparation method of composite lipopeptide capable of preventing high-temperature inactivation
By mixing the fermented lipopeptide mixture with modified phospholipid compounds and cholesterol, a composite lipopeptide liposome suspension is constructed and spray-dried at high temperature, the problem of inactivation of antibacterial lipopeptide during high temperature drying is solved, and the effect of maintaining antibacterial activity under high temperature conditions is achieved.
CN119685432AActive Publication Date: 2025-03-25JIAXING HAORUI BIOTECHNOLOGY CO LTD
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Patent Information
- Application Number
- CN202510005038.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-02
- Publication Date
- 2025-03-25
- Estimated Expiration
- 2045-01-02
AI Technical Summary
Technical Problem
Antibacterial lipopeptides are prone to inactivate during high-temperature drying, resulting in a reduced antibacterial effect.
Method used
The fermented lipopeptide mixture was mixed with the modified phospholipid compound and cholesterol to construct a composite lipopeptide liposome suspension. After spray-drying at high temperature, the obtained composite lipopeptide still has good antibacterial activity.
Benefits of technology
By modifying the combination of phospholipid compounds and cholesterol, the constructed complex lipopeptide liposomes can maintain antibacterial activity under high temperature conditions, solving the problem of inactivation of antibacterial lipopeptides during high temperature drying.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention discloses a preparation method of composite lipopeptide capable of preventing high-temperature inactivation, and belongs to the technical field of bioactive peptide preparation. The preparation method comprises the following steps: mixing and dissolving a modified phospholipid compound, cholesterol and chloroform, and performing rotary evaporation to obtain a lipid film; mixing and shaking the lipid film, the lipopeptide mixture and a phosphate buffer solution, and performing ultrasonic treatment to obtain a composite lipopeptide liposome suspension; and carrying out spray drying on the composite lipopeptide liposome suspension to obtain composite lipopeptide powder. A lipopeptide mixture obtained through fermentation is mixed with a modified phospholipid compound and cholesterol, a high-temperature-resistant composite lipopeptide liposome suspension is constructed, and after high-temperature spray drying, the obtained composite lipopeptide still has good antibacterial activity.
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