Capsule preparation with high grease content and preparation method thereof

Abstract

The invention provides a capsule preparation with high grease content and a preparation method thereof, and relates to the technical field. The capsule preparation with high grease content comprises the following raw materials in percentage by weight: 20%-80% of grease microcapsule powder, 1%-42% of rice meal, 2%-12% of calcium hydrogen phosphate, 1%-6% of calcium silicate, 1%-21% of microcrystalline cellulose, 2%-10% of magnesium stearate and 1%-10% of silicon dioxide. The calcium hydrophosphate, the calcium silicate, the magnesium stearate and the silicon dioxide are adopted as additives of the oil / grease microcapsule powder, the high-content (50-80%) oil / grease capsule preparation can be prepared by optimizing the proportion and the process, a filling rod or a copper disc cannot be stuck in the production process, and the product loading capacity is stable.

Description

Technical Field

[0001] The present application relates to the field of capsule technology, and in particular to a capsule preparation with a high fat content and a preparation method thereof. Background Art

[0002] Microcapsule refers to a micro container or package with a polymer or inorganic wall. Microencapsulation technology is a technology that encapsulates solid, liquid or gaseous active substances with materials. The use of microencapsulation technology can mask the bad taste and odor of the encapsulated substances, control the release rate and method of the active substances, improve the matching degree between the active substances and the environment, reduce incompatibility taboos, and isolate oxygen, water and other factors that affect the stability of the active substances. Microencapsulation technology has been used in many industrial fields for many years and there are many methods, such as disc coating, spray drying, spray freezing, fluidized bed, sharp hole method, interfacial polymerization, in situ polymerization, etc.

[0003] Powdered fats convert liquid fats into fluid solid powders, which are convenient for storage, transportation and use. The fats are wrapped by the membrane formed by the wall material, and the microcapsules form a layer of protection for the fats in the core material, which can prevent the effects of oxygen, heat, light and other environmental and chemical substances on the fats, and extend the storage period of the fats. Because powdered fats have many advantages over liquid fats, they are widely used in the food and feed fields.

[0004] When oil / lipid microcapsule powder or extract is produced into capsules or tablets, if the added amount is too high, it is easy to stick to the filling rod or copper plate, and production cannot be carried out. Therefore, the addition amount of oil / lipid microcapsule powder or extract in the product formula is generally within 30%. Summary of the invention

[0005] The purpose of the present application is to provide a capsule preparation with a high fat content, which has the advantage of a high fat content (60-80%).

[0006] Another object of the present application is to provide a method for preparing a capsule preparation with a high fat content, which is simple and ingenious.

[0007] In order to solve the above technical problems, the technical solution adopted in this application is:

[0008] On the one hand, the present application provides a capsule preparation with a high fat content, which comprises the following raw materials, by weight percentage: 20%-80% of fat microcapsule powder, 1%-42% of rice flour, 2%-12% of calcium hydrogen phosphate, 1%-6% of calcium silicate, 1%-21% of microcrystalline cellulose, 2%-10% of magnesium stearate and 1%-10% of silicon dioxide.

[0009] On the other hand, the present application provides a method for preparing a capsule preparation with a high fat content, comprising the following steps:

[0010] S1. Add the oil microcapsule powder, calcium silicate and silicon dioxide into a three-dimensional motion mixer in order, set the total mixer speed to 10 rpm, mix for 15 min, and mix until the color is uniform to obtain a premix;

[0011] S2. Put the premix, rice flour, calcium silicate, microcrystalline cellulose, magnesium stearate, etc. into a three-dimensional motion mixer, set the total mixer speed to 10 rpm, mix for 15 min, and mix until the color is uniform to obtain a mixture.

[0012] S3. Fill the mixture into the 0# mold of the fully automatic capsule filling machine at a production speed of 1100 capsules / min. Debugging should be carried out before filling. Formal production can only be carried out after the filling amount, filling amount control range, capsule locking, appearance quality, etc. meet the requirements. The filling amount during the filling process is 420 mg / capsule, the filling amount control range is: 420 mg×(1±5%), and the disintegration time limit is ≤30 min.

[0013] The functions of each raw material in this application are as follows:

[0014] Magnesium stearate: also known as magnesium octadecanoate, it has the dual characteristics of metal salt and stearic acid. The inherent fat properties of stearic acid (including lubricity and water repellency) are retained in magnesium stearate. Magnesium stearate is a white or milky white uniform powder with a large specific surface area and strong adsorption and hygroscopicity. Food grade magnesium stearate can be used as a food processing aid, mainly as a lubricant, anti-adhesive agent, and flow aid for tablets and capsules.

[0015] Silicon dioxide: Silicon dioxide is a white loose powder. According to the Chinese Pharmacopoeia, Volume II, silicon dioxide is mainly used as a flow aid and suspending agent. The surface of oil / grease microcapsule powder is rough. Adding silicon dioxide can reduce the friction between particles, increase the loose density and tap density, reduce the compression, and improve its fluidity.

[0016] Anhydrous calcium hydrogen phosphate: Anhydrous calcium hydrogen phosphate is a white, odorless, tasteless powder or crystal, existing in the form of triclinic crystals. Anhydrous calcium hydrogen phosphate has good fluidity and stability, low hygroscopicity, and will not be hydrated to form dihydrate. It is used as a filler in tablets and hard capsules to increase volume and assist in molding.

[0017] Calcium silicate: Calcium silicate is a white to off-white crystalline or amorphous powder, defined as calcium oxide and silicon dioxide in different proportions, including tricalcium silicate and dicalcium silicate, divided into anhydrous and hydrated types. Calcium silicate is obtained by the reaction of newly slaked lime and synthetic silicon dioxide. Calcium silicate is a loose porous structure with high oil and water absorption values. Calcium silicate covers the surface of the oil / grease microcapsule powder to form a protective film, isolating the effect of external moisture on the material, thereby playing an anti-caking and flow-aiding role, and improving its bulk density.

[0018] Microcrystalline cellulose: Microcrystalline cellulose is a linear polysaccharide bonded by β-1,4 glucosidic bonds. It is a natural polymer composed of free-flowing cellulose crystals. Microcrystalline cellulose is insoluble in water, dilute acid and oil. It has bonding and shaping functions. It has properties such as low degree of polymerization (between 15 and 375) and large specific surface area. Microcrystalline cellulose can also reduce friction between material particles and improve the fluidity of materials. It can be used as a filler to increase volume and assist in molding.

[0019] Compared with the prior art, the embodiments of the present application have at least the following advantages or beneficial effects:

[0020] The present application adopts calcium hydrogen phosphate, magnesium stearate and silicon dioxide as additives for oil / fat microcapsule powder, and can prepare high-content (60-80%) oil / fat capsule preparations by optimizing the ratio and process, and the filling rod or copper plate will not stick during the production process. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0022] Figure 1 A three-dimensional motion mixer used in the embodiment of the present application;

[0023] Figure 2 A fully automatic capsule filling machine used in the embodiment of the present application;

[0024] Figure 3 This is a physical picture of the capsule product prepared in the example of the present application. DETAILED DESCRIPTION

[0025] In order to make the purpose, technical scheme and advantages of the embodiments of the present application clearer, the technical scheme in the embodiments of the present application will be described clearly and completely below. If the specific conditions are not specified in the embodiments, they are carried out according to the conventional conditions or the conditions recommended by the manufacturer. If the manufacturer is not specified for the reagents or instruments used, they are all conventional products that can be purchased commercially.

[0026] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present application can be combined with each other. The present application will be described in detail below with reference to specific embodiments.

[0027] A capsule preparation with a high fat content comprises the following raw materials, measured by weight percentage: 20%-80% of fat microcapsule powder, 1%-42% of rice flour, 2%-12% of calcium hydrogen phosphate, 1%-6% of calcium silicate, 1%-21% of microcrystalline cellulose, 2%-10% of magnesium stearate and 1%-10% of silicon dioxide.

[0028] In some embodiments of the present application, the above-mentioned high-fat capsule preparation includes the following raw materials, measured in weight percentage: 60%-80% of fat microcapsule powder, 1%-10% of rice flour, 2%-6% of calcium hydrogen phosphate, 1%-6% of calcium silicate, 1%-6% of microcrystalline cellulose, 2%-7% of magnesium stearate and 2%-6% of silicon dioxide.

[0029] In some embodiments of the present application, the above-mentioned lipid microcapsule powder is vitamin E powder, fish oil microcapsule powder or lutein / lutein ester microcapsule powder.

[0030] In some embodiments of the present application, the VE content in the above vitamin E powder is 98%; the total content of EPA and DHA in the fish oil microcapsule powder is 40%.

[0031] A method for preparing a capsule preparation with a high fat content comprises the following steps:

[0032] S1. First, mix the oil microcapsule powder, calcium silicate and silicon dioxide until the color is uniform to obtain a premix;

[0033] S2, mixing the premix with other raw materials to obtain a mixture;

[0034] S3, filling the mixture into capsules.

[0035] In some embodiments of the present application, the mixing in the above step S1 is specifically as follows: the oil microcapsule powder, calcium silicate and silicon dioxide are put into a three-dimensional motion mixer in sequence, the speed is set to 10 rpm, the mixing time is 15 minutes, and the premix is ​​obtained by mixing until the color is uniform.

[0036] In some embodiments of the present application, the mixing in the above-mentioned S2 step is specifically as follows: putting the premix, rice flour, calcium silicate, microcrystalline cellulose, magnesium stearate, etc. into a three-dimensional motion mixer, setting the total mixer speed to 10 rpm, and the mixing time to 15 minutes; mixing until the color is uniform to obtain a mixture.

[0037] In some embodiments of the present application, the capsule filling in the above-mentioned S3 step is specifically as follows: using a fully automatic capsule filling machine 0# mold for filling; the production speed is 1100 capsules / min, the filling amount is 420 mg / capsule, the mass of each capsule is 420 mg×(1±5%), and the disintegration time limit is ≤30 min.

[0038] The features and performance of the present application are further described in detail below in conjunction with the embodiments.

[0039] Example 1

[0040] A capsule preparation with high fat content is prepared by the following method:

[0041] S1. Prepare raw materials, by weight percentage: vitamin E powder (VE content 98%) 60.00%, rice flour 10.00%, calcium hydrogen phosphate 6.00%, calcium silicate 6.00%, microcrystalline cellulose 6.00%, magnesium stearate 6.00% and silicon dioxide 6.00%;

[0042] S2, put the oil microcapsule powder, calcium silicate and silicon dioxide into the three-dimensional motion mixer in sequence, such as Figure 1 As shown, the speed of the total mixer was set to 10 rpm, the mixing time was 15 min, and the premix was obtained by mixing until the color was uniform;

[0043] S3. Put the premix, rice flour, calcium silicate, microcrystalline cellulose, magnesium stearate, etc. into a three-dimensional motion mixer, set the total mixer speed to 10 rpm, mix for 15 min, and mix until the color is uniform to obtain a mixture.

[0044] S4, fill the mixture into the 0# mold of the fully automatic capsule filling machine. Figure 2 As shown, the production speed is 1100 capsules / min. The filling process must be debugged first. The formal production can only be carried out after the filling amount and filling amount control range, capsule locking, appearance quality, etc. meet the requirements. The filling process is 420mg / capsule. The capsule product is as follows Figure 3 shown.

[0045] The production process of the product in this example is smooth, the filling amount is stable (±3.9%) and meets the requirements, and it does not stick to the filling rod or the copper plate. The disintegration time limit is 17 minutes.

[0046] Example 2

[0047] A capsule preparation with high fat content is prepared by the following method:

[0048] S1. Prepare raw materials, weight percentage: vitamin E powder (VE content 98%) 80.00%, rice flour: 1.00%, calcium hydrogen phosphate 2.00%, calcium silicate: 3.00%, microcrystalline cellulose: 1.00%, magnesium stearate 7.00% and silicon dioxide 6.00%;

[0049] S2, put the oil microcapsule powder, calcium silicate and silicon dioxide into the three-dimensional motion mixer in order, set the total mixer speed to 10 rpm, the mixing time to 15 min, and mix until the color is uniform to obtain a premix;

[0050] S3. Put the premix, rice flour, calcium silicate, microcrystalline cellulose, magnesium stearate, etc. into a three-dimensional motion mixer, set the total mixer speed to 10 rpm, mix for 15 min, and mix until the color is uniform to obtain a mixture.

[0051] S4. Fill the mixture into the 0# mold of the fully automatic capsule filling machine at a production speed of 1100 capsules / min. Debugging should be carried out before filling. Formal production can only be carried out after the filling amount, filling amount control range, capsule locking, appearance quality, etc. meet the requirements. The filling amount during the filling process is 420 mg / capsule.

[0052] The production process of the product in this example is smooth, the filling amount is stable (±5.0%) and meets the requirements, and it does not stick to the filling rod or the copper plate. The disintegration time limit is 15 minutes.

[0053] Example 3

[0054] A capsule preparation with high fat content is prepared by the following method:

[0055] S1. Prepare raw materials, by weight percentage: vitamin E powder (VE content 98%) 20.00%, rice flour 42.00%, calcium hydrogen phosphate 12.00%, calcium silicate 1.00%, microcrystalline cellulose 21.00%, magnesium stearate 2.00% and silicon dioxide 2.00%;

[0056] S2, put the oil microcapsule powder, calcium silicate and silicon dioxide into the three-dimensional motion mixer in order, set the total mixer speed to 10 rpm, the mixing time to 15 min, and mix until the color is uniform to obtain a premix;

[0057] S3. Put the premix, rice flour, calcium silicate, microcrystalline cellulose, magnesium stearate, etc. into a three-dimensional motion mixer, set the total mixer speed to 10 rpm, mix for 15 min, and mix until the color is uniform to obtain a mixture.

[0058] S4. Fill the mixture into the 0# mold of the fully automatic capsule filling machine at a production speed of 1100 capsules / min. Debugging should be carried out before filling. Formal production can only be carried out after the filling amount, filling amount control range, capsule locking, appearance quality, etc. meet the requirements. The filling amount during the filling process is 420 mg / capsule.

[0059] The production process of the product in this example is smooth, the filling amount is stable (±3.2%) and meets the requirements, and it does not stick to the filling rod or the copper plate. The disintegration time limit is 15 minutes.

[0060] Example 4

[0061] A capsule preparation with high fat content is prepared by the following method:

[0062] S1. Prepare raw materials, weight percentage: vitamin E powder (VE content 98%) 30.00%, rice flour 22.00%, calcium hydrogen phosphate 30.00%, calcium silicate 3.00%, microcrystalline cellulose 5.00%, magnesium stearate 5.00% and silicon dioxide 5.00%;

[0063] S2, put the oil microcapsule powder, calcium silicate and silicon dioxide into the three-dimensional motion mixer in order, set the total mixer speed to 10 rpm, the mixing time to 15 min, and mix until the color is uniform to obtain a premix;

[0064] S3. Put the premix, rice flour, calcium silicate, microcrystalline cellulose, magnesium stearate, etc. into a three-dimensional motion mixer, set the total mixer speed to 10 rpm, mix for 15 min, and mix until the color is uniform to obtain a mixture.

[0065] S4. Fill the mixture into the 0# mold of the fully automatic capsule filling machine at a production speed of 1100 capsules / min. Debugging should be carried out before filling. Formal production can only be carried out after the filling amount, filling amount control range, capsule locking, appearance quality, etc. meet the requirements. The filling amount during the filling process is 420 mg / capsule.

[0066] The production process of the product in this example is smooth, the filling amount is stable (±4.7%) and meets the requirements, and it does not stick to the filling rod or the copper plate. The disintegration time limit is 12 minutes.

[0067] Example 5

[0068] A capsule preparation with high fat content is prepared by the following method:

[0069] S1. Prepare raw materials, weight percentage: vitamin E powder (VE content 98%) 85.00%, rice flour 1.00%, calcium hydrogen phosphate 3.00%, calcium silicate 4%, microcrystalline cellulose 2%, magnesium stearate 2.00% and silicon dioxide 3.00%;

[0070] S2, put the oil microcapsule powder, calcium silicate and silicon dioxide into the three-dimensional motion mixer in order, set the total mixer speed to 10 rpm, the mixing time to 15 min, and mix until the color is uniform to obtain a premix;

[0071] S3. Put the premix, rice flour, calcium silicate, microcrystalline cellulose, magnesium stearate, etc. into a three-dimensional motion mixer, set the total mixer speed to 10 rpm, mix for 15 min, and mix until the color is uniform to obtain a mixture.

[0072] S4, the mixture was filled into the 0# mold of the fully automatic capsule filling machine. The amount of vitamin E powder added in the product of this embodiment was too high, the production process was not smooth, the filling amount difference fluctuated greatly by 8.7%, the material adhered to the filling rod, and the copper plate was stuck. The trial production failed.

[0073] Comparative Example 1

[0074] S1. Prepare raw materials, by weight percentage: vitamin E powder (VE content 98%) 50.00%, rice flour 40.00%, calcium hydrogen phosphate 0.00%, calcium silicate: 4.00%, microcrystalline cellulose 2.00%, magnesium stearate 2.00% and silicon dioxide 2.00%;

[0075] S2. First, add vitamin E powder, calcium silicate and silicon dioxide into the equipment, set the speed of the total mixer to 10 rpm, mix for 15 min, and mix until the color is uniform to obtain a premix;

[0076] S3. Put the premix, rice flour, calcium silicate, microcrystalline cellulose, magnesium stearate, etc. into a three-dimensional motion mixer, set the total mixer speed to 10 rpm, mix for 15 min, and mix until the color is uniform to obtain a mixture.

[0077] S4. Fill the mixture using the 0# mold of the fully automatic capsule filling machine. This comparative example does not contain calcium hydrogen phosphate, which is not smooth in the production process of high-fat microcapsule powder. The filling amount fluctuates greatly by 7.3%, the material sticks to the filling rod, and the trial production fails.

[0078] Comparative Example 2

[0079] S1. Prepare raw materials, by weight percentage: vitamin E powder (VE content 98%) 50.00%, rice flour 40.00%, calcium hydrogen phosphate 4.00%, calcium silicate 0.00%, microcrystalline cellulose 2.00%, magnesium stearate 2.00% and silicon dioxide 2.00%;

[0080] S2. First, add vitamin E powder, calcium silicate and silicon dioxide into the equipment, set the speed of the total mixer to 10 rpm, mix for 15 min, and mix until the color is uniform to obtain a premix;

[0081] S3. Put the premix, rice flour, calcium silicate, microcrystalline cellulose, magnesium stearate, etc. into a three-dimensional motion mixer, set the total mixer speed to 10 rpm, mix for 15 min, and mix until the color is uniform to obtain a mixture.

[0082] S4. The mixture was filled into the 0# mold of the fully automatic capsule filling machine. This comparative example did not contain calcium silicate, which resulted in an unsmooth production process, a large fluctuation of 9.1% in the filling amount, and the material adhered to the filling rod, resulting in a trial production failure.

[0083] Comparative Example 3

[0084] S1. Prepare raw materials, by weight percentage: 50.00% vitamin E powder (VE content 98%), 40.00% rice flour, 4.00% calcium hydrogen phosphate, 2.00% calcium silicate, 2.00% microcrystalline cellulose, 2.00% magnesium stearate and 0.00% silicon dioxide;

[0085] S2. First, add vitamin E powder, calcium silicate and silicon dioxide into the equipment, set the speed of the total mixer to 10 rpm, mix for 15 min, and mix until the color is uniform to obtain a premix;

[0086] S3. Put the premix, rice flour, calcium silicate, microcrystalline cellulose, magnesium stearate, etc. into a three-dimensional motion mixer, set the total mixer speed to 10 rpm, mix for 15 min, and mix until the color is uniform to obtain a mixture.

[0087] S4. Fill the mixture using the 0# mold of a fully automatic capsule filling machine. In this comparative example, there is no silicon dioxide, the production process is not smooth, the filling amount difference fluctuates greatly by 8.4%, the material sticks to the filling rod, and the trial production fails.

[0088] The embodiments described above are part of the embodiments of the present application, rather than all of the embodiments. The detailed description of the embodiments of the present application is not intended to limit the scope of the present application for protection, but merely represents the selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without making creative work belong to the scope of protection of the present application.

Claims

1. A capsule preparation with high fat content, characterized in that: Calculated by weight percentage, the invention comprises the following raw materials: 20%-80% of oil microcapsule powder, 1%-42% of rice flour, 2%-12% of calcium hydrogen phosphate, 1%-6% of calcium silicate, 1%-21% of microcrystalline cellulose, 2%-10% of magnesium stearate and 1%-10% of silicon dioxide.

2. A capsule preparation with high fat content according to claim 1, characterized in that: Calculated by weight percentage, the invention comprises the following raw materials: 60%-80% of oil microcapsule powder, 1%-10% of rice flour, 2%-6% of calcium hydrogen phosphate, 1%-6% of calcium silicate, 1%-6% of microcrystalline cellulose, 2%-7% of magnesium stearate and 2%-6% of silicon dioxide.

3. A capsule preparation with high fat content according to claim 1 or 2, characterized in that: The oil microcapsule powder is vitamin E powder, fish oil microcapsule powder or lutein / lutein ester microcapsule powder.

4. A capsule preparation with high fat content according to claim 3, characterized in that: The VE content in the vitamin E powder is 98%; the total content of EPA and DHA in the fish oil microcapsule powder is 40%.

5. A method for preparing a capsule preparation with a high fat content as claimed in any one of claims 1 to 4, characterized in that: The following steps are involved: S1. First, mix the oil microcapsule powder, calcium silicate and silicon dioxide until the color is uniform to obtain a premix; S2, mixing the premix with other raw materials to obtain a mixture; S3, filling the mixture into capsules.

6. The method for preparing a capsule preparation with high fat content according to claim 5, characterized in that: The mixing in step S1 is specifically as follows: putting the oil microcapsule powder, calcium silicate and silicon dioxide into a three-dimensional motion mixer in order, setting the rotation speed to 10 rpm, mixing time to 15 minutes, and mixing until the color is uniform to obtain a premix.

7. The method for preparing a capsule preparation with high fat content according to claim 5, characterized in that: The mixing in step S2 is specifically as follows: putting the premix, rice flour, calcium silicate, microcrystalline cellulose, magnesium stearate, etc. into a three-dimensional motion mixer, setting the total mixer speed to 10 rpm and the mixing time to 15 minutes; mixing until the color is uniform to obtain a mixture.

8. The method for preparing a capsule preparation with high fat content according to claim 5, characterized in that: The capsule filling in the step S3 is specifically as follows: using a fully automatic capsule filling machine 0# mold for filling; the production speed is 1100 capsules / min, the filling amount is 420 mg / capsule, the mass of each capsule is 420 mg×(1±5%), and the disintegration time limit is ≤30 min.

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