Antioxidant whitening composition, cosmetic and preparation method thereof

Abstract

The invention relates to the technical field of cosmetics, and relates to an antioxidant whitening composition, a cosmetic and a preparation method thereof. When the antioxidant whitening composition comprises two of gallic acid, procyanidine or rutin, the mass ratio of any two raw materials is (1-3): (1-3); and / or when the antioxidant whitening composition comprises three of gallic acid, procyanidine and rutin, the mass ratio of gallic acid to procyanidine to rutin in the antioxidant whitening composition is (4-8): (1-3): (1-3) according to the mass ratio. According to the anti-oxidation whitening composition, the synergistic interaction effect is achieved, the anti-oxidation effect of the composition is effectively improved, and particularly the ABTS free radical scavenging rate is remarkable. Meanwhile, all the components in the composition cooperate with one another, and the inhibition effect on tyrosinase is also obviously improved. When the antioxidant whitening composition is applied to cosmetics, the unbalance of the redox state of the skin can be improved.

Description

Technical Field

[0001] The present application relates to the technical field of cosmetics, and in particular to an antioxidant whitening composition, cosmetics and a preparation method thereof. Background Art

[0002] The skin is affected by external pollution and internal stress, which will produce reactive oxygen and free radicals, causing an imbalance in the redox state. Excessive free radicals not only cause cell damage, but also induce tyrosinase activity, leading to pigment deposition. In addition, free radicals are also involved in causing skin inflammation, inducing a series of skin problems including inflammatory aging, skin sensitivity, fine lines and wrinkles, etc.

[0003] However, there is currently a lack of natural green skin care products on the market that can improve the imbalance of the skin's redox state. Summary of the invention

[0004] The purpose of the embodiments of the present application is to provide an antioxidant whitening composition and cosmetics.

[0005] In a first aspect, the present application provides an antioxidant whitening composition, the antioxidant whitening composition comprising: at least two of gallic acid, proanthocyanidins, and rutin;

[0006] When the antioxidant whitening composition comprises: two of gallic acid, proanthocyanidins or rutin, the mass ratio of any two raw materials is (1-3): (1-3); and / or

[0007] When the antioxidant whitening composition includes three of gallic acid, proanthocyanidins and rutin, the mass ratio of gallic acid, proanthocyanidins and rutin in the antioxidant whitening composition is (4-8): (1-3): (1-3).

[0008] In the above technical scheme, in the antioxidant whitening composition, each component of gallic acid, proanthocyanidins, and rutin is derived from plant secondary metabolites, which are green and natural; and they are compounded within the above-mentioned mass ratio range, and the various components cooperate with each other to achieve a synergistic effect, effectively improving the antioxidant effect of the composition, especially the ABTS free radical scavenging rate. At the same time, the various components in the composition cooperate with each other, and the inhibitory effect on tyrosinase is also significantly improved; thereby effectively improving the whitening effect of the composition. Applying this antioxidant whitening composition to cosmetics can improve the imbalance of the skin's redox state, and effectively improve the problems of excessive free radicals causing cell damage, pigmentation, etc. caused by the imbalance of the skin's redox state.

[0009] Furthermore, the composition provided by the above technical scheme of the present invention, each component is derived from plant secondary metabolites, is green and natural, and is more suitable for skin care; and each component has clear efficacy and can synergize to enhance the effect, improve the antioxidant and whitening effect, and is more suitable for industrial production; applying it to cosmetics can greatly enhance the antioxidant and whitening effect of cosmetics; and meet the market demand for green and natural antioxidant products.

[0010] In other embodiments of the present application, when the antioxidant whitening composition includes three of gallic acid, proanthocyanidins and rutin, the mass ratio of gallic acid, proanthocyanidins and rutin in the antioxidant whitening composition is (5-7): (1.5-2.5): (1.5-2.5).

[0011] In other embodiments of the present application, when the antioxidant whitening composition includes gallic acid, proanthocyanidins and rutin, the mass ratio of gallic acid, proanthocyanidins and rutin in the antioxidant whitening composition is 6:2:2.

[0012] In other embodiments of the present application, the antioxidant whitening composition includes: a gallic acid aqueous solution, a proanthocyanidin aqueous solution, and a rutin alkaline solution.

[0013] In other embodiments of the present application, the mass percentage of gallic acid in the gallic acid aqueous solution is 0.005%-0.05% by mass.

[0014] In other embodiments of the present application, the mass percentage of proanthocyanidins in the proanthocyanidin aqueous solution is 0.005%-0.05% by mass.

[0015] In other embodiments of the present application, the rutin alkaline solution includes rutin and an aqueous sodium hydroxide solution;

[0016] In terms of mass percentage, the mass percentage of rutin in the rutin alkaline solution is 0.005%-0.05%;

[0017] In terms of mass percentage, the mass percentage of sodium hydroxide in the sodium hydroxide aqueous solution is 0.1% to 1.5%.

[0018] In a second aspect, the present application provides a cosmetic comprising the antioxidant whitening composition provided by any embodiment of the first aspect.

[0019] In other embodiments of the present application, the amount of the antioxidant whitening composition added to the cosmetic is 5% or more by mass.

[0020] In other embodiments of the present application, the cosmetic further comprises: the cosmetic further comprises a water phase, an oil phase, and optionally a preservative;

[0021] In other embodiments of the present application, the aqueous phase includes glycerol, butylene glycol, and water;

[0022] In other embodiments of the present application, the oil phase includes: sodium hyaluronate, xanthan gum;

[0023] In other embodiments of the present application, the preservatives include: caprylhydroxamic acid, ethylhexylglycerin, 1,2-hexanediol;

[0024] In other embodiments of the present application, the cosmetics include, by mass percentage: 1% to 5% glycerin, 4% to 6% butylene glycol, 0.01% to 1.00% sodium hyaluronate, 0.01% to 0.20% xanthan gum, 0.010% to 0.030% caprylhydroxamic acid, 0.010% to 0.020% ethylhexylglycerin, 0.010% to 0.020% 1,2-hexanediol, 5% to 20% antioxidant whitening composition, and deionized water is supplemented to 100%.

[0025] In other embodiments of the present application, the pH of the cosmetic is 6.5-7.5.

[0026] In a third aspect, some embodiments of the present application provide a method for preparing a cosmetic, comprising:

[0027] mixing the oil phase raw materials to obtain an oil phase mixture;

[0028] mixing water phase raw materials to obtain a water phase mixture;

[0029] mixing and emulsifying the oil phase mixture and the water phase mixture to obtain an emulsified mixture;

[0030] After the emulsified mixture is cooled to below 40° C., the antioxidant whitening composition is added to the emulsified mixture and mixed evenly;

[0031] Optionally, mixing the oil phase raw materials includes: dissolving the oil phase raw materials at 75° C. to 85° C. and mixing them uniformly;

[0032] Optionally, mixing the aqueous phase raw materials comprises: heating the aqueous phase raw materials at 75° C. to 85° C. and mixing them uniformly;

[0033] Optionally, the oil phase mixture and the water phase mixture are mixed and emulsified, including: mixing the oil phase mixture and the water phase mixture at 400 rpm to 600 rpm and continuously stirring for 5 minutes to 15 minutes for emulsification. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0035] Figure 1 The scavenging effects of various embodiments and comparative examples on ABTS free radicals;

[0036] Figure 2 The scavenging effects of various embodiments and comparative examples on DPPH free radicals;

[0037] Figure 3 The figures are the inhibitory effects of various embodiments and comparative examples on tyrosinase. DETAILED DESCRIPTION

[0038] In order to make the purpose, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments.

[0039] Therefore, the following detailed description of the embodiments of the present application is not intended to limit the scope of the present application for protection, but merely represents selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present application.

[0040] Research has found that the use of antioxidants in skin care products can fundamentally solve a variety of skin problems and prevent a series of skin damage caused by free radicals, and has a wide range of applicability. Previous studies have shown that common antioxidants such as vitamin C and vitamin E have good antioxidant capacity and can prevent skin photoaging. However, these antioxidants are not natural and green enough, and long-term use may have other side effects; the market demand for plant extracts as natural antioxidants is increasing.

[0041] However, most plant extracts have complex compositions, unclear functional substances, and potential stability, compatibility, and sensitization issues. Based on this, the present application provides a natural skin care composition derived from plant secondary metabolites, with clear functional ingredients and synergistic effects, and with significant antioxidant and whitening effects, which is of great significance.

[0042] The present application embodiment provides an antioxidant whitening composition, the antioxidant whitening composition comprising: at least two of gallic acid, proanthocyanidins, and rutin;

[0043] When the antioxidant whitening composition comprises: two of gallic acid, proanthocyanidins or rutin, the mass ratio of any two raw materials is (1-3): (1-3); and / or

[0044] When the antioxidant whitening composition includes three of gallic acid, proanthocyanidins and rutin, the mass ratio of gallic acid, proanthocyanidins and rutin in the antioxidant whitening composition is (4-8): (1-3): (1-3).

[0045] In the above technical scheme, in the antioxidant whitening composition, each component of gallic acid, proanthocyanidins, and rutin is derived from plant secondary metabolites, which are green and natural; and they are compounded within the above mass ratio range, and the various components cooperate with each other to achieve a synergistic effect, effectively improving the antioxidant effect of the composition, especially the ABTS free radical scavenging rate. At the same time, the various components in the composition cooperate with each other, and the inhibitory effect on tyrosinase is also significantly improved; thereby effectively improving the whitening effect of the composition.

[0046] Furthermore, in the above technical solution, rutin is a natural flavonoid compound with antioxidant, anti-inflammatory, anti-allergic and vascular elasticity enhancing effects. It can reduce skin redness and swelling, repair vascular damage, and promote blood circulation. However, rutin has very poor water solubility, which limits its usage and dosage in skin care products. Gallic acid and proanthocyanidins contain excellent polyphenols, which have strong antioxidant activity, can neutralize free radicals and protect cells from oxidative stress, and are highly water-soluble; in the above technical solution, by combining gallic acid and proanthocyanidins with rutin within the above-mentioned suitable ratio range; the application of rutin in cosmetics is effectively realized; and a synergistic effect is produced, which enhances the antioxidant and whitening effects.

[0047] Furthermore, it was found through research that the antioxidant effect of the composition of the present invention, especially the ABTS free radical scavenging rate, is significantly better than that of any single compound, which not only saves costs but also shows that gallic acid, proanthocyanidins and rutin in the composition of the present invention have a synergistic effect in antioxidant effect, and none of the three is indispensable. In addition, the inhibitory effect of the composition on tyrosinase is also significantly better than the effect of other single compounds.

[0048] Furthermore, the composition provided by the above technical scheme of the present invention, each component is derived from plant secondary metabolites, is green and natural, and is more suitable for skin care; and each component has clear efficacy and can synergize to enhance the effect, improve the antioxidant and whitening effect, and is more suitable for industrial production; applying it to cosmetics can greatly enhance the antioxidant and whitening effect of cosmetics; and meet the market demand for green and natural antioxidant products.

[0049] Further optionally, exemplarily, in some embodiments of the present application, when the antioxidant whitening composition includes three of gallic acid, proanthocyanidins and rutin, the mass ratio of gallic acid, proanthocyanidins and rutin in the antioxidant whitening composition is (4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8 or the range between any two of the foregoing values): (1, 1.2, 1.3, 1.5, 2, 2.2, 2.5, 2.8, 3 or the range between any two of the foregoing values): (1, 1.2, 1.3, 1.5, 1.8, 2, 2.2, 2.5, 2.8, 3 or the range between any two of the foregoing values).

[0050] Further optionally, in some embodiments of the present application, when the antioxidant whitening composition includes three of gallic acid, proanthocyanidins and rutin, the mass ratio of gallic acid, proanthocyanidins and rutin in the antioxidant whitening composition is (5-7): (1.5-2.5): (1.5-2.5).

[0051] Further optionally, in some embodiments of the present application, when the antioxidant whitening composition includes gallic acid, proanthocyanidins and rutin, the mass ratio of gallic acid, proanthocyanidins and rutin in the antioxidant whitening composition is 6:2:2.

[0052] Further optionally, in some embodiments of the present application, when the antioxidant whitening composition includes: two of gallic acid, proanthocyanidins or rutin, the mass ratio of any two raw materials is (1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9 or 3): (1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9 or 3).

[0053] Further optionally, in some embodiments of the present application, the antioxidant whitening composition includes: an aqueous solution of gallic acid, an aqueous solution of proanthocyanidins, and an alkaline solution of rutin.

[0054] Further optionally, in some embodiments of the present application, the mass percentage of gallic acid in the gallic acid aqueous solution is 0.005%-0.05% by mass.

[0055] Further optionally, in some embodiments of the present application, the mass percentage of gallic acid in the gallic acid aqueous solution is 0.01%-0.05% by mass.

[0056] Illustratively, in some embodiments of the present application, the mass percentage of gallic acid in the above-mentioned gallic acid aqueous solution is 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.01%, 0.015%, 0.02%, 0.025%, 0.03%, 0.035%, 0.04%, 0.045%, 0.05% or a range between any two of the foregoing values.

[0057] Further optionally, in some embodiments of the present application, the mass percentage of proanthocyanidins in the proanthocyanidin aqueous solution is 0.005%-0.05% by mass.

[0058] Illustratively, in some embodiments of the present application, the mass percentage of proanthocyanidins in the above-mentioned proanthocyanidin aqueous solution is 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.01%, 0.015%, 0.02%, 0.025%, 0.03%, 0.035%, 0.04%, 0.045%, 0.05% or a range between any two of the foregoing values.

[0059] Further optionally, in some embodiments of the present application, further optionally, in some embodiments of the present application, the mass percentage of proanthocyanidins in the proanthocyanidin aqueous solution is 0.01%-0.05%, calculated as a mass percentage.

[0060] Further optionally, in some embodiments of the present application, the rutin alkaline solution comprises rutin and an aqueous sodium hydroxide solution.

[0061] In terms of mass percentage, the mass percentage of rutin in the rutin alkaline solution is 0.005%-0.05%.

[0062] Illustratively, in some embodiments of the present application, the mass percentage of rutin in the above-mentioned rutin alkaline solution is 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.01%, 0.015%, 0.02%, 0.025%, 0.03%, 0.035%, 0.04%, 0.045%, 0.05% or a range between any two of the foregoing values.

[0063] Further optionally, in some embodiments of the present application, the mass percentage of rutin in the rutin alkaline solution is 0.01%-0.05% by mass.

[0064] Further optionally, in some embodiments of the present application, the mass percentage of sodium hydroxide in the sodium hydroxide aqueous solution is 0.1% to 1.5% by mass.

[0065] Illustratively, in some embodiments of the present application, the mass percentage of sodium hydroxide in the above-mentioned sodium hydroxide aqueous solution is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5% or the range between any two of the foregoing values, measured by mass percentage.

[0066] Further optionally, in some embodiments of the present application, the mass percentage of sodium hydroxide in the sodium hydroxide aqueous solution is 0.5% to 1.0% by mass.

[0067] Some embodiments of the present application provide a cosmetic comprising the antioxidant whitening composition provided in any of the aforementioned embodiments.

[0068] Further optionally, in some embodiments of the present application, the amount of the antioxidant whitening composition added to the cosmetic is 5% or more by mass.

[0069] Illustratively, in some embodiments of the present application, the amount of the antioxidant whitening composition added to the cosmetic is 5%, 6%, 7%, 8%, 9%, 10%, 12%, 15%, 18%, 20% or a range between any two of the foregoing values, measured in mass percentage.

[0070] Further optionally, in some embodiments of the present application, the amount of the antioxidant whitening composition added to the cosmetic is 5% to 20% by mass.

[0071] Further optionally, in some embodiments of the present application, the cosmetic further comprises a water phase, an oil phase and optionally a preservative.

[0072] Further optionally, in some embodiments of the present application, the aqueous phase includes glycerol, butylene glycol, and water.

[0073] Further optionally, in some embodiments of the present application, the oil phase includes: sodium hyaluronate and xanthan gum.

[0074] Further optionally, in some embodiments of the present application, the preservatives include: caprylhydroxamic acid, ethylhexylglycerin, and 1,2-hexanediol.

[0075] Further optionally, in some embodiments of the present application, the cosmetics include, by mass percentage: 1% to 5% glycerin, 4% to 6% butylene glycol, 0.01% to 1.00% sodium hyaluronate, 0.01% to 0.20% xanthan gum, 0.010% to 0.030% caprylhydroxamic acid, 0.010% to 0.020% ethylhexylglycerol, 0.010% to 0.020% 1,2-hexanediol, 5% to 20% antioxidant whitening composition, and deionized water is supplemented to 100%.

[0076] Illustratively, in some embodiments of the present application, the cosmetic comprises, by mass percentage: glycerin 1%, 1.2%, 1.5%, 1.8%, 2%, 2.2%, 2.5%, 2.8%, 3%, 3.2%, 3.5%, 3.8%, 4%, 4.2%, 4.5%, 4.8%, 5% or a range between any two of the foregoing values;

[0077] Butanediol 4%, 4.1%, 4.2%, 4.5%, 4.8%, 5.0%, 5.2%, 5.5%, 5.8%, 6% or the range between any two of the foregoing values;

[0078] Sodium hyaluronate 0.01%, 0.02%, 0.05%, 0.08%, 0.1%, 0.2%, 0.3%, 0.5%, 0.8%, 1.00% or the range between any two of the foregoing values;

[0079] Xanthan gum 0.01%, 0.02%, 0.05%, 0.08%, 0.1%, 0.12%, 0.15%, 0.18%, 0.20% or the range between any two of the foregoing values;

[0080] Caprylhydroxamic acid 0.010%, 0.012%, 0.015%, 0.018%, 0.020%, 0.022%, 0.025%, 0.028%, 0.030% or the range between any two of the foregoing values;

[0081] Ethylhexylglycerin 0.010%, 0.011%, 0.012%, 0.013%, 0.015%, 0.018%, 0.020% or the range between any two of the foregoing values;

[0082] 1,2-Hexanediol 0.010%, 0.012%, 0.015%, 0.018%, 0.020% or the range between any two of the foregoing values;

[0083] 5%, 6%, 8%, 10%, 12%, 15%, 18%, 20% or the range between any two of the foregoing values ​​of the antioxidant whitening composition; and deionized water is supplemented to 100%.

[0084] Further optionally, in some embodiments of the present application, the pH of the cosmetic is 6.5-7.5.

[0085] Illustratively, in some embodiments of the present application, the pH of the cosmetic is 6.5, 6.6, 6.7, 6.8, 6.9, 7.0, 7.1, 7.2, 7.3, 7.4, 7.5 or a range between any two of the foregoing values.

[0086] Further optionally, in some embodiments of the present application, the pH of the above-mentioned cosmetics can be adjusted by adding a weak acid.

[0087] For example, in some embodiments of the present application, citric acid or the like may be selected to adjust the pH.

[0088] Some embodiments of the present application provide a method for preparing a lotion containing an antioxidant whitening composition, the method comprising:

[0089] mixing the oil phase raw materials to obtain an oil phase mixture;

[0090] mixing water phase raw materials to obtain a water phase mixture;

[0091] mixing and emulsifying the oil phase mixture and the water phase mixture to obtain an emulsified mixture;

[0092] After the emulsified mixture is cooled to below 40° C., the antioxidant whitening composition is added to the emulsified mixture and mixed evenly.

[0093] Optionally, in some embodiments of the present application, mixing the oil phase raw materials includes: dissolving the oil phase raw materials at 75° C. to 85° C. and mixing them uniformly.

[0094] Optionally, in some embodiments of the present application, mixing the aqueous phase raw materials includes: heating the aqueous phase raw materials at 75° C. to 85° C. and mixing them uniformly.

[0095] Optionally, in some embodiments of the present application, the oil phase mixture and the water phase mixture are mixed and emulsified, including: mixing the oil phase mixture and the water phase mixture at 400 rpm to 600 rpm and continuously stirring for 5 minutes to 15 minutes for emulsification.

[0096] Illustratively, in some embodiments of the present application, the preparation method of the lotion containing the antioxidant whitening composition is carried out according to the following steps:

[0097] Step S1, dissolving butanediol in glycerol, heating to 75° C. to 85° C. to dissolve, to obtain an oil phase mixture.

[0098] Illustratively, in some embodiments of the present application, butanediol is dissolved in glycerol and heated to 75°C, 76°C, 77°C, 78°C, 79°C, 80°C, 81°C, 82°C, 83°C, 84°C, 85°C or a range between any two of the foregoing values ​​to obtain an oil phase mixture.

[0099] Step S2, dissolving sodium hyaluronate and xanthan gum in water and heating the mixture to 75° C. to 85° C. to obtain an aqueous phase mixture.

[0100] Illustratively, in some embodiments of the present application, sodium hyaluronate and xanthan gum are dissolved in water and heated to 75°C, 76°C, 77°C, 78°C, 79°C, 80°C, 81°C, 82°C, 83°C, 84°C, 85°C or a range between any two of the foregoing values ​​to obtain an aqueous mixture.

[0101] Step S3, the water phase mixture and the oil phase mixture prepared above are successively pumped into an emulsifying pot, and stirred continuously at 400 rpm to 600 rpm for 5 minutes to 15 minutes to obtain an emulsified mixture.

[0102] Illustratively, in some embodiments of the present application, the aqueous phase mixture and the oil phase mixture prepared above are successively pumped into an emulsifying pot, and stirred at 400 rpm, 410 rpm, 420 rpm, 430 rpm, 450 rpm, 480 rpm, 500 rpm, 500 rpm, 520 rpm, 550 rpm, 580 rpm, 600 rpm or in a range between any two of the aforementioned values; and stirred continuously for 5 minutes, 6 minutes, 7 minutes, 8 minutes, 9 minutes, 10 minutes, 11 minutes, 12 minutes, 13 minutes, 14 minutes, 15 minutes or in a range between any two of the aforementioned values ​​to obtain an emulsified mixture.

[0103] Step S4: After the emulsified mixture obtained in the above step S3 has cooled to room temperature, caprylhydroxamic acid, ethylhexylglycerol and 1,2-hexanediol are added, and the mixture is continuously stirred at 400 rpm to 600 rpm for 5 to 15 minutes.

[0104] Exemplarily, in some embodiments of the present application, after the emulsified mixture obtained in the aforementioned step S3 is cooled to room temperature, caprylhydroxamic acid, ethylhexylglycerol, and 1,2-hexanediol are added at 400 rpm, 410 rpm, 420 rpm, 430 rpm, 450 rpm, 480 rpm, 500 rpm, 500 rpm, 520 rpm, 550 rpm, 580 rpm, 600 rpm, or in the range between any two of the aforementioned values; stirring is continued for 5 minutes, 6 minutes, 7 minutes, 8 minutes, 9 minutes, 10 minutes, 11 minutes, 12 minutes, 13 minutes, 14 minutes, 15 minutes, or in the range between any two of the aforementioned values.

[0105] Step S5: After the emulsified mixture cools to room temperature, add the antioxidant whitening composition provided in any of the above embodiments, and continue stirring at 400 rpm to 600 rpm for 5 minutes to 15 minutes.

[0106] Illustratively, in some embodiments of the present application, after the emulsified mixture is cooled to room temperature, the antioxidant whitening composition provided by any of the foregoing embodiments is added, and the mixture is stirred at 400 rpm, 410 rpm, 420 rpm, 430 rpm, 450 rpm, 480 rpm, 500 rpm, 500 rpm, 520 rpm, 550 rpm, 580 rpm, 600 rpm, or in a range between any two of the foregoing values; stirring is continued for 5 minutes, 6 minutes, 7 minutes, 8 minutes, 9 minutes, 10 minutes, 11 minutes, 12 minutes, 13 minutes, 14 minutes, 15 minutes, or in a range between any two of the foregoing values.

[0107] Step S6, adding an appropriate amount of citric acid and stirring evenly, adjusting the pH to 6.5-7.5, thereby preparing a lotion containing an antioxidant whitening composition.

[0108] Illustratively, in some embodiments of the present application, an appropriate amount of citric acid is added and stirred evenly, and the pH is adjusted to 6.5, 6.6, 6.7, 6.8, 6.9, 7.0, 7.1, 7.2, 7.3, 7.4, or 7.5 to prepare a lotion containing an antioxidant whitening composition.

[0109] The features and performance of the present application are further described in detail below in conjunction with the embodiments:

[0110] Examples 1-6

[0111] A lotion is provided, and an antioxidant whitening composition is prepared in a total amount of 100 mL. The final concentrations of the components (gallic acid, proanthocyanidins, and rutin) in the composition are shown in Table 1 in terms of mass percentage. Then, 1000 mL of lotion is prepared using the compositions prepared in each embodiment according to the formula and preparation process steps in Table 2.

[0112] Example 7

[0113] Provided is a lotion. 0.0300 g of gallic acid and 0.0100 g of proanthocyanidin are dissolved in 90 mL of deionized water, and 0.0100 g of rutin is dissolved in 10 mL of 1% NaOH aqueous solution, and the mixture is mixed as an antioxidant whitening composition. Then, 1000 mL of lotion is prepared according to the formula and preparation process steps in Table 2.

[0114] Examples 8-12

[0115] A lotion is provided, and an antioxidant whitening composition is prepared in a total amount of 100 mL. The final concentrations of the components (gallic acid, proanthocyanidins, and rutin) in the composition are shown in Table 1 in terms of mass percentage. Then, 1000 mL of lotion is prepared using the compositions prepared in each embodiment according to the formula and preparation process steps in Table 2.

[0116] Table 1 Antioxidant whitening composition (mass percentage)

[0117]

[0118]

[0119] Table 2 Composition of lotion

[0120] Element Content (mass percentage) glycerin 3％ Butanediol 5.4％ Sodium Hyaluronate 0.05％ Xanthan gum 0.1％ Octanoylhydroxamic acid 0.025％ Ethylhexylglycerin 0.015％ 1,2-Hexanediol 0.015％ Antioxidant whitening composition 10％ Deionized water To 100%

[0121] The steps of making lotion are as follows:

[0122] (1) Dissolve butanediol in glycerol and heat to 80°C to dissolve, which is the oil phase;

[0123] (2) Dissolve sodium hyaluronate and xanthan gum in water and heat to 80°C to obtain the aqueous phase;

[0124] (3) The water phase and the oil phase were pumped into the emulsification pot successively and stirred continuously at 500 rpm for 10 minutes;

[0125] (4) After the mixture cools to room temperature, caprylhydroxamic acid, ethylhexylglycerol, and 1,2-hexanediol are added, and stirring is continued at 500 rpm for 10 minutes;

[0126] (5) After the mixture cooled to room temperature, the antioxidant whitening composition prepared in each example was added respectively, and the mixture was stirred at 500 rpm for 10 minutes;

[0127] (6) Add an appropriate amount of citric acid and stir evenly, and adjust the pH to 6.5-7.5 to obtain a lotion containing an antioxidant whitening composition.

[0128] Comparative Example 1

[0129] Negative control, i.e. deionized water.

[0130] Comparative Example 2

[0131] The positive controls were 200 μg / mL vitamin C aqueous solution in the ABTS free radical scavenging test, 20 μg / mL vitamin C aqueous solution in the DPPH free radical scavenging test, and 80 μg / mL kojic acid aqueous solution in the tyrosinase inhibition test.

[0132] Comparative Example 3

[0133] The blank control, i.e., a lotion without the antioxidant whitening composition, is prepared by mixing the following raw material components in percentage by weight:

[0134] Glycerin 3%, butylene glycol 5.4%, sodium hyaluronate 0.05%, xanthan gum 0.1%, caprylhydroxamic acid 0.025%, ethylhexylglycerin 0.015%, 1,2-hexanediol 0.015%, deionized water to 100%; appropriate amount of citric acid, adjust pH to 6.5-7.5.

[0135] Comparative Example 4

[0136] Prepared as follows:

[0137] First, 0.0250 g of gallic acid was dissolved in 100 mL of deionized water as an antioxidant whitening composition, and then 1000 mL of lotion was prepared according to the formula and preparation steps in Table 2 above.

[0138] Comparative Example 5

[0139] Prepared as follows:

[0140] First, 0.0250 g of proanthocyanidins was dissolved in 100 mL of deionized water as an antioxidant whitening composition, and then 1000 mL of lotion was prepared according to the formula and preparation steps in Table 2 above.

[0141] Comparative Example 6

[0142] Prepared as follows:

[0143] First, 0.0250 g of rutin was dissolved in 10 mL of 1% NaOH aqueous solution, and water was added to make up to 100 mL as an antioxidant whitening composition. Then, 1000 mL of lotion was prepared according to the formula and preparation steps in Table 2 above.

[0144] Comparative Example 7

[0145] First, 0.0250 g of gallic acid and 0.0250 g of thymol were dissolved in 100 mL of deionized water as an antioxidant whitening composition, and then 1000 mL of lotion was prepared according to the formula and preparation steps in Table 2 above.

[0146] Comparative Example 8

[0147] First, 0.0100 g of proanthocyanidin was dissolved in 90 mL of deionized water, and 0.0100 g of rutin and 0.0300 g of kinetin were dissolved in 10 mL of 1% NaOH aqueous solution, and the mixture was used as an antioxidant whitening composition. Then, 1000 mL of lotion was prepared according to the formula and preparation steps in Table 2 above.

[0148] Comparative Example 9

[0149] First, 0.0250 g of gallic acid and 0.0250 g of glucosamine were dissolved in 100 mL of deionized water as an antioxidant whitening composition, and then 1000 mL of lotion was prepared according to the formula and preparation steps in Table 2 above.

[0150] Comparative Example 10

[0151] First, dissolve 0.0100g of gallic acid, 0.0100g of proanthocyanidins, and 0.0100g of thymol in 90mL of deionized water, and dissolve 0.0100g of rutin and 0.0100g of kinetin in 10mL of 1% NaOH aqueous solution, and mix them as an antioxidant whitening composition. Then, prepare 1000mL of lotion according to the formula and preparation steps in Table 2 above.

[0152] Comparative Example 11

[0153] First, 5 mL of grape seed extract (commercial raw material) was dissolved in 100 mL of deionized water as an antioxidant whitening composition, and then 1000 mL of lotion was prepared according to the formula and preparation steps in Table 2 above.

[0154] Comparative Example 12

[0155] First, 5 mL of tea extract (commercial raw material) was dissolved in 100 mL of deionized water as an antioxidant whitening composition, and then 1000 mL of lotion was prepared according to the formula and preparation steps in Table 2 above.

[0156]

Performance test

[0157] 1. ABTS free radical scavenging test

[0158] Test method:

[0159] The ABTS free radical scavenging test was carried out with reference to the content of standard T / GDCA 021-2023 “Chemical Evaluation Method for the Evaluation of Antioxidant Activity of Cosmetics” to calculate the ABTS free radical scavenging rate of each embodiment and comparative example.

[0160] See the instruction manual for test results Figure 1 .

[0161] Depend on Figure 1 It can be seen that the ABTS free radical scavenging rate is ranked as follows: Example 4> Example 7> Example 1> Comparative Examples 3-12. That is, when any one of gallic acid, proanthocyanidins and rutin is used alone, the highest ABTS free radical scavenging rate obtained by the test is 49.32%; and when the three raw materials are used in combination according to the proportion of the present application, they can play an excellent synergistic role with each other, so that the ABTS free radical scavenging rate of the antioxidant whitening composition can reach 81.90% to 87.90% (Example 7, Example 4); which are significantly higher than Comparative Examples 3-12.

[0162] 2. DPPH free radical scavenging test

[0163] Test method:

[0164] Referring to the content of standard T / GDCA 021-2023 "Chemical Evaluation Method for Evaluation of Antioxidant Activity of Cosmetics", the DPPH radical scavenging rate of each embodiment and comparative example was calculated.

[0165] See the instruction manual for test results Figure 2 .

[0166] Depend on Figure 2 It can be seen that the DPPH radical scavenging rate is ranked as follows: Example 4> Example 1> Example 7> Comparative Examples 3-12. The DPPH radical scavenging rates of the above three examples are all similar to the positive control (Comparative Example 2), indicating that the antioxidant whitening composition has a very high DPPH radical scavenging rate.

[0167] 3. Tyrosinase inhibition test

[0168] Test method:

[0169] Referring to the content of standard T / GDCA 006-2021 "Test method for inhibition of tyrosinase activity by cosmetic raw materials (in vitro method)", the tyrosinase inhibition rate of each embodiment and comparative example was calculated.

[0170] See the instruction manual for test results Figure 3 .

[0171] Depend on Figure 3 It can be seen that the tyrosinase inhibition rate is ranked as follows: Example 10> Example 7> Example 5> Comparative Example 3-Comparative Example 12. Among them, the tyrosinase inhibition rates of Example 10 and Example 7 are significantly greater than those of Comparative Example 3-Comparative Example 12, indicating that gallic acid, proanthocyanidins and rutin have a certain synergistic effect after being compounded according to the ratio of this application, which significantly improves the tyrosinase inhibition rate.

[0172] In summary, the present invention provides an antioxidant whitening composition derived from plant secondary metabolites, with clear ingredients and synergistic effects, which has important practical significance.

[0173] The above description is only the preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. An antioxidant whitening composition, characterized in that: The antioxidant whitening composition comprises: at least two of gallic acid, proanthocyanidins, and rutin; When the antioxidant whitening composition comprises: two of gallic acid, proanthocyanidins or rutin, the mass ratio of any two raw materials is (1-3): (1-3); and / or When the antioxidant whitening composition comprises three of gallic acid, proanthocyanidins and rutin, the mass ratio of the gallic acid, the proanthocyanidins and the rutin in the antioxidant whitening composition is (4-8): (1-3): (1-3).

2. The antioxidant whitening composition according to claim 1, characterized in that: When the antioxidant whitening composition comprises three of gallic acid, proanthocyanidins and rutin, the mass ratio of the gallic acid, the proanthocyanidins and the rutin in the antioxidant whitening composition is (5-7): (1.5-2.5): (1.5-2.5).

3. The antioxidant whitening composition according to claim 1, characterized in that: When the antioxidant whitening composition comprises gallic acid, proanthocyanidins and rutin, the mass ratio of the gallic acid, the proanthocyanidins and the rutin in the antioxidant whitening composition is 6:2:

2.

4. The antioxidant whitening composition according to any one of claims 1 to 3, characterized in that: The antioxidant whitening composition comprises: a gallic acid aqueous solution, a proanthocyanidin aqueous solution, and a rutin alkaline solution.

5. The antioxidant whitening composition according to claim 4, characterized in that: In terms of mass percentage, the mass percentage of gallic acid in the gallic acid aqueous solution is 0.005%-0.05%.

6. The antioxidant whitening composition according to claim 4, characterized in that: In terms of mass percentage, the mass percentage of the proanthocyanidins in the proanthocyanidins aqueous solution is 0.005%-0.05%.

7. The antioxidant whitening composition according to claim 4, characterized in that: The rutin alkaline solution comprises rutin and a sodium hydroxide aqueous solution; In terms of mass percentage, the mass percentage of rutin in the rutin alkaline solution is 0.005%-0.05%; In terms of mass percentage, the mass percentage of the sodium hydroxide in the sodium hydroxide aqueous solution is 0.1% to 1.5%.

8. A cosmetic, characterized in that: The cosmetic comprises the antioxidant whitening composition according to any one of claims 1 to 7.

9. The cosmetic according to claim 8, characterized in that: In the cosmetic, the antioxidant whitening composition is added in an amount of 5% or more by mass; Optionally, the cosmetic further comprises a water phase, an oil phase and optionally a preservative; Optionally, the aqueous phase comprises glycerol, butylene glycol, and water; Optionally, the oil phase includes: sodium hyaluronate, xanthan gum; Optionally, the preservative includes: caprylhydroxamic acid, ethylhexylglycerin, 1,2-hexanediol; Optionally, the cosmetic comprises, by mass percentage: 1% to 5% glycerol, 4% to 6% butylene glycol, 0.01% to 1.00% sodium hyaluronate, 0.01% to 0.20% xanthan gum, 0.010% to 0.030% caprylhydroxamic acid, 0.010% to 0.020% ethylhexylglycerol, 0.010% to 0.020% 1,2-hexanediol, 5% to 20% antioxidant whitening composition, and deionized water is supplemented to 100%; Optionally, the pH of the cosmetic is 6.5-7.

5.

10. A method for preparing cosmetics, characterized in that: include: mixing the oil phase raw materials to obtain an oil phase mixture; mixing water phase raw materials to obtain a water phase mixture; mixing and emulsifying the oil phase mixture and the water phase mixture to obtain an emulsified mixture; After the emulsified mixture is cooled to below 40° C., the antioxidant whitening composition is added to the emulsified mixture and mixed evenly; Optionally, the mixing of the oil phase raw materials comprises: dissolving the oil phase raw materials at 75° C. to 85° C. and mixing them uniformly; Optionally, the mixing of the aqueous phase raw materials comprises: heating the aqueous phase raw materials at 75° C. to 85° C. and mixing them uniformly; Optionally, the oil phase mixture and the water phase mixture are mixed and emulsified, comprising: mixing the oil phase mixture and the water phase mixture at 400 rpm to 600 rpm and continuously stirring for 5 minutes to 15 minutes for emulsification.

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