Skin-care water emulsion containing butyric acid and laminarin and preparation method of skin-care water emulsion

Abstract

The invention discloses a skin care lotion containing butyric acid laminarin and a preparation method thereof. The skin care water emulsion is prepared from the following raw materials in parts by weight: 35 to 45 parts of propylene glycol, 2 to 3 parts of polyethylene glycol, 15 to 25 parts of butyric acid laminarin, 2 to 12 parts of glutathione, 3 to 10 parts of astaxanthin, 2 to 10 parts of carnosine, 4 to 8 parts of herba centellae extract, 3 to 8 parts of biotin, 1 to 4 parts of vitamin A alcohol, 1 to 2 parts of nicotinamide, 1 to 2 parts of ceramide, 0.5 to 2 parts of arbutin, 1 to 2 parts of cetostearyl alcohol and 5 to 10 parts of water. Natural materials are adopted as main raw materials, the use safety is greatly improved, the lotion can be suitable for wider crowds, meanwhile, the butyric acid laminarin and the centella asiatica extract are specially added to be compounded, the effect of polysaccharide is played to the maximum extent, and the prepared skin care lotion has the effects of preserving moisture, brightening, whitening, resisting aging and improving the skin condition.

Description

Technical Field

[0001] The invention belongs to the field of skin care products, and particularly relates to a skin care lotion containing laminarin butyrate and a preparation method thereof. Background Art

[0002] With the advancement of technology and the improvement of living standards, people's demand for beauty and skin care is growing. They are no longer satisfied with the basic cleaning function, but pursue higher-level skin care effects, such as moisturizing, anti-oxidation, whitening and anti-aging. Based on the huge demand for beauty and skin care, skin care products with various functions have emerged on the market, but most of them achieve these functions by adding various chemical raw materials. Although these products may have certain effects on some people's skin, they may also bring greater safety hazards, especially for people with sensitive skin, and their production process will also pollute the environment. In order to meet consumers' demand for safe and healthy skin care products, more and more brands have begun to develop safer and more environmentally friendly skin care products, trying to use natural ingredients as the main components, aiming to reduce skin irritation and impact on the environment. However, most of the skin care products claiming natural ingredients have poor actual use effects, and the moisturizing, anti-aging, brightening and other effects are not significant or take effect slowly. Summary of the invention

[0003] The purpose of the present invention is to disclose a skin care lotion containing laminarin butyrate to solve one or more technical problems existing in the prior art and to provide at least one beneficial option or create conditions.

[0004] To achieve the above object, the present invention is implemented through the following technical solutions: The first aspect of the present invention is to provide a skin care lotion.

[0005] The second aspect of the present invention is to provide a method for preparing the skin care lotion described in the first aspect of the present invention.

[0006] The raw materials of the skin care lotion described in the first aspect of the present invention include, by weight, 10 to 100 parts of propylene glycol, 0.1 to 5 parts of polyethylene glycol, 5 to 50 parts of laminarin butyrate, 0.1 to 20 parts of glutathione, 0.1 to 20 parts of astaxanthin, 0.1 to 20 parts of carnosine, 0.1 to 20 parts of Centella asiatica extract, 0.1 to 10 parts of biotin, 0.1 to 10 parts of vitamin A alcohol, 0.1 to 10 parts of niacinamide, 0.1 to 10 parts of ceramide, 0.1 to 10 parts of arbutin, 0.1 to 4 parts of cetostearyl alcohol and 1 to 20 parts of water.

[0007] The skin care lotion of the present invention adds a derivative of laminarin, laminarin butyrate. The laminarin butyrate is obtained by chemically modifying laminarin with butyric acid, and contains a large number of butyl groups on its sugar chain. Butyl groups can improve the solubility of polysaccharides in water, reduce the interaction between water molecules and polysaccharide molecules, and reduce the hydrogen bonds between polysaccharide molecules, thereby improving their dispersibility in the aqueous phase system. At the same time, butyl modification can also improve the lipophilicity of polysaccharides, making it easier to penetrate the skin and enhance its moisturizing and repairing effects. Laminarin butyrate has good antioxidant activity, can effectively remove DPPH and ABTS free radicals, help the skin resist the damage of free radicals, and delay aging; laminarin butyrate has good anti-tyrosinase activity, can inhibit the production of melanin, reduce skin pigmentation, and help whiten and brighten the skin color. Therefore, the skin care lotion containing laminarin butyrate has high biocompatibility and safety in use, and has a mild effect.

[0008] The skin care lotion of the present invention contains propylene glycol and polyethylene glycol, which have a solvent effect and can help other ingredients dissolve and mix, thereby improving the stability of the product; at the same time, they also act as moisturizers to help the skin retain moisture, so that the active ingredients in the skin care lotion can better penetrate into the skin.

[0009] The skin care lotion of the present invention also contains astaxanthin, carnosine, glutathione and centella asiatica extract, which can play a good role in anti-oxidation, neutralizing free radicals, protecting skin cells and maintaining normal skin metabolism. Among them, astaxanthin can also help reduce the appearance of wrinkles and fine lines and improve skin elasticity; carnosine can also stimulate the production of collagen, promote the repair of barrier function, and effectively prevent skin aging; glutathione can also help brighten the skin tone, reduce pigmentation and freckles. Centella asiatica extract and laminarin butyrate can produce a mutual synergistic effect, so that the skin care lotion has the effect of repairing damaged skin and promoting collagen production, and can improve skin pigmentation, brighten the skin tone, and maintain skin elasticity and firmness.

[0010] The present invention also adds biotin, vitamin A alcohol, nicotinamide, ceramide, arbutin and cetostearyl alcohol as raw materials. Biotin helps to maintain the health of skin, hair and nails and promotes the metabolism of skin cells; vitamin A alcohol promotes collagen production, reduces fine lines and wrinkles, improves skin elasticity and firmness, and helps anti-aging. Ceramide can maintain the skin barrier, moisturize, resist aging, increase skin elasticity, and reduce wrinkles. Niacinamide has the effects of whitening, strengthening the skin barrier, anti-inflammatory, oil control and shrinking pores. Arbutin can inhibit tyrosinase activity and reduce melanin production to achieve the effect of whitening and fading spots. Cetostearyl alcohol, as an emulsifier and stabilizer, helps to form a stable emulsion system and provide a moisturizing effect.

[0011] In some embodiments of the first aspect of the present invention, the raw materials of the skin care lotion include, by weight: 30-60 parts of propylene glycol, 1-3 parts of polyethylene glycol, 10-40 parts of laminarin butyrate, 1-15 parts of glutathione, 1-15 parts of astaxanthin, 1-15 parts of carnosine, 1-15 parts of Centella asiatica extract, 1-10 parts of biotin, 1-10 parts of vitamin A alcohol, 1-5 parts of niacinamide, 1-5 parts of ceramide, 0.1-5 parts of arbutin, 0.1-5 parts of cetostearyl alcohol, and 1-15 parts of water.

[0012] In a further embodiment, the raw materials of the skin care lotion include, by weight: 35-45 parts of propylene glycol, 2-3 parts of polyethylene glycol, 15-25 parts of laminarin butyrate, 2-12 parts of glutathione, 3-10 parts of astaxanthin, 2-10 parts of carnosine, 4-8 parts of Centella asiatica extract, 3-8 parts of biotin, 1-4 parts of vitamin A alcohol, 1-2 parts of niacinamide, 1-2 parts of ceramide, 0.5-2 parts of arbutin, 1-2 parts of cetostearyl alcohol, and 5-10 parts of water.

[0013] In some embodiments of the first aspect of the present invention, the butyrate laminarin is prepared by the following steps: (1) vacuum drying the laminarin powder to obtain a dry solid product; (2) adding the solid product to a solution of trifluoroacetic anhydride (TFAA) and butyric acid, and allowing the mixture to react sufficiently to obtain a reaction solution; (3) adding distilled water to the reaction solution and centrifuging, removing the supernatant, and drying the precipitate to obtain a residue; (4) re-dissolving the residue with distilled water; (5) The reconstituted solution obtained in step (4) is dialyzed and freeze-dried to obtain butyrate laminarin.

[0014] Preferably, in step (1), the laminarin powder is dried under vacuum at 70-80° C. for 1-2 hours, and more preferably under vacuum at 70° C. for 2 hours.

[0015] Preferably, in step (2), the mass volume ratio of the solid product to the TFAA and butyric acid solution is 1 g: (35-45) mL: (10-15) mL; a more preferred mass volume ratio is 1 g: 40 mL: 12 mL.

[0016] Preferably, in step (2), the reaction condition of the mixture is stirring at 45-55° C. for 0.5-2 hours, and more preferably the reaction condition is stirring at 50° C. for 1 hour.

[0017] Preferably, in step (3), the ratio of the reaction solution to distilled water is 1:(3-5). A more preferred ratio is 1:4.

[0018] Preferably, in step (3), the centrifugation condition is 8000-10000 rpm for 10-15 minutes.

[0019] Preferably, in step (3), the drying condition of the precipitate is: 50-70°C for 1-4 hours. More preferably, the drying condition of the precipitate is 60°C for 3 hours.

[0020] Preferably, in step (4), the ratio of the residue to distilled water is 1:(10-20). A more preferred ratio is 1:15.

[0021] Preferably, in step (5), the dialysis condition of the reconstituted solution is to use a dialysis bag with a molecular weight cutoff of 1.4 kDa, place the reconstituted solution in the dialysis bag, and dialyze for at least 24 hours.

[0022] The synthetic route in the preparation process is as follows:

[0023] Among them, Laminarin Butyrate (LB) is the butyrate laminarin.

[0024] The preparation method of the skin care lotion according to the second aspect of the present invention comprises the following steps: Glutathione, astaxanthin, carnosine and Centella asiatica extract are mixed to obtain mixture A; biotin, vitamin A alcohol, niacinamide, ceramide, arbutin and cetostearyl alcohol are added to the mixture A and stirred evenly, and propylene glycol and polyethylene glycol are added in batches during stirring to obtain mixture B; butyric acid laminarin is dissolved in water to obtain liquid C; finally, the mixture B and the liquid C are mixed evenly to obtain the skin care lotion.

[0025] The beneficial effects of the present invention are as follows: the present invention adopts natural materials as raw materials, which greatly improves the safety of use and can be applicable to a wider range of people. At the same time, butyrate laminarin polysaccharide is specially added for compounding and the efficacy of the polysaccharide is maximized. The prepared skin care lotion has multiple functions such as moisturizing, anti-aging, brightening and improving skin conditions, and has a large market prospect. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 This is the hydrogen NMR spectrum of butyrate laminarin; Figure 2 This is a diagram showing the effect of laminarin butyrate in scavenging DPPH free radicals; Figure 3 This is a diagram showing the effect of laminarin butyrate in scavenging ABTS free radicals; Figure 4This is a diagram showing the effect of laminarin butyrate on inhibiting the activity of tyrosinase; DETAILED DESCRIPTION The following will be combined with the embodiments and drawings to clearly and completely describe the concept of the present invention and the technical effects produced, so as to fully understand the purpose, scheme and effect of the present invention. It should be noted that the embodiments and features in the embodiments of this application can be combined with each other without conflict.

[0027] Example 1. Preparation of butyrate laminarin.

[0028] The specific process is as follows: (1) vacuum drying the kelp powder at 70° C. for 2 hours to obtain a dry solid product; (2) adding the solid product to a premixed solution of TFAA and butyric acid, wherein the mass volume ratio of the solid product, TFAA and acetic acid is 1 g:40 mL:12 mL, and the mixture is fully stirred at 50° C. for 1 hour to obtain a reaction solution; (3) adding 4 times the volume of distilled water to the reaction solution and centrifuging at 10,000 rpm for 15 minutes, removing the supernatant, and drying the precipitate at 60° C. for 3 hours to obtain a residue; (4) re-dissolving the residue with distilled water; (5) The reconstituted solution obtained in step (4) was placed in a dialysis bag with a molecular weight of 1.4 kDa and dialyzed for 24 hours, and then freeze-dried to obtain butyrated laminarin.

[0029] Example 2: The butyric acid laminarin obtained in Example 1 was subjected to nuclear magnetic resonance spectroscopy ( 1 H NMR) analysis.

[0030] Take 30 mg of the butyrate laminarin sample prepared in Example 1 and dissolve it in D 2 O, and the NMR was used to record the 1 H-NMR spectrum. The results are as follows Figure 1 As shown in the figure, there is an obvious signal at δ0.7-2.3, which indicates that there are many butyl groups on the sugar chain of butyric acid laminarin. Butyl groups can improve the solubility of polysaccharides in water, reduce the interaction between water molecules and polysaccharide molecules, and reduce the hydrogen bonds between polysaccharide molecules, thereby improving the dispersibility of polysaccharides in the aqueous phase system. At the same time, butyl modification can also increase the lipophilicity of polysaccharides, making them easier to penetrate the skin and enhancing their moisturizing and repairing effects.

[0031] Example 3: Experiment on scavenging DPPH free radicals by laminarin butyrate.

[0032] The butyrate laminarin sample prepared in Example 1 was prepared into butyrate laminarin solutions of different concentrations (0.5, 1, 1.5, 2, 2.5 and 3 mg / mL, respectively) with anhydrous ethanol for later use.

[0033] 2 mL of 0.004% (w / v) DPPH solution was mixed evenly with 2 mL of laminarin butyrate solutions of different concentrations to obtain mixed solutions. After incubation in the dark at room temperature for 30 minutes, the absorbance was measured at 517 nm and recorded as A.

[0034] 2 mL of anhydrous ethanol solution was mixed with 2 mL of laminarin butyrate solutions of different concentrations to obtain mixed solutions. The absorbance was measured at 517 nm and recorded as A. 0 .

[0035] Measure the absorbance of 0.004% (w / v) DPPH in distilled water at 517 nm and record it as A 1 .

[0036] DPPH free radical scavenging rate (%) = (1-(AA 0 ) / A 1 )×100% Control experiments were conducted by replacing butyrate laminarin solution (LB) with 0.5, 1, 1.5, 2, 2.5 and 3 mg / mL acetylated laminarin solution (LA). Figure 2 As shown in the results, with the increase of the concentration of butyrate laminarin polysaccharide, the scavenging effect of DPPH free radicals was enhanced, indicating that butyrate laminarin polysaccharide has a good ability to scavenge DPPH free radicals, and its ability to scavenge DPPH free radicals is dose-dependent with the concentration of polysaccharide.

[0037] Example 4: Experiment on scavenging ABTS free radicals by laminarin butyrate.

[0038] The butyrate laminarin sample prepared in Example 1 was prepared with water to prepare butyrate laminarin aqueous solutions of different concentrations (concentrations were 0.5, 1, 1.5, 2, 2.5 and 3 mg / mL respectively) for later use.

[0039] Mix 5 mL ABTS (7 mmol / L) with 88 μL 149 mmol / L K 2 S 2 O 8 Mix to generate ABTS free radicals, then take 2 mL of the mixed solution, add 2 mL of butyrate laminarin aqueous solution of different concentrations to obtain the test solution, incubate for 16 hours under dark conditions, and measure the absorbance at 734 nm, which is recorded as A.

[0040] Take 2 mL of tri-hydrochloric acid buffer and add 2 mL of butyrate laminarin aqueous solution of different concentrations, and measure the absorbance at 734 nm, which is recorded as A. 0 .

[0041] ABTS free radical scavenging effect (%) = (A 0 -A)×100% Control experiments were performed with 0.5, 1, 1.5, 2, 2.5, and 3 mg / mL LA replacing LB. Figure 3 As shown in the figure, with the increase of the concentration of butyrate laminarin polysaccharide, the scavenging effect of ABTS free radicals was enhanced, indicating that butyrate laminarin polysaccharide has a good ability to scavenge ABTS free radicals, and its ability to scavenge ABTS free radicals is dose-dependent with the polysaccharide concentration.

[0042] Example 5: Experiment on the inhibition of tyrosinase activity by laminarin butyrate.

[0043]

[0044] According to the reaction systems of group C1, group C2, group C3 and group C4 in Table 1, the corresponding solutions were accurately aspirated and sampled. First, different concentrations of butyric laminarin solution (the diluent was PBS, and the concentrations of butyric laminarin were 0.25, 0.5, 1, 1.5, 2 and 2.5 mg / mL, respectively), L-tyrosine solution (tyrosinase monophenolase) or L-dopa solution (tyrosinase diphenolase) and pH 6.8 phosphate buffered saline (PBS) were added to the test tubes, and placed in a water bath at 37°C for 10 minutes. Then, tyrosinase solution was added to the mixed solution, and the mixture was placed in a water bath at 37°C for 14 minutes. The absorbance at 475 nm was measured and recorded as A.

[0045] Tyrosinase inhibition rate (%) = [1-(A C3 -A C4 ) / (A C1 -A C2 )]×100% Control experiments were conducted by replacing LB with LA at 0.5, 1, 1.5, 2, 2.5, and 3 mg / mL. C1 , A C2 , A C3 , A C4 are the absorbance values ​​of systems C1, C2, C3, and C4 respectively. Figure 4 As shown, with the increase of the concentration of laminarin butyrate, the inhibitory effect of tyrosinase increased, indicating that laminarin butyrate has a good ability to inhibit tyrosinase activity, and its ability to inhibit tyrosinase activity is dose-dependent with the concentration of polysaccharide.

[0046] Example 6: Prepare No. 1 skin care lotion.

[0047] The raw materials of No. 1 skin care lotion include, by weight: 40 parts of propylene glycol, 2 parts of polyethylene glycol, 20 parts of laminarin butyrate, 8 parts of glutathione, 6 parts of astaxanthin, 5 parts of carnosine, 5 parts of Centella asiatica extract, 6 parts of biotin, 3 parts of vitamin A alcohol, 2 parts of niacinamide, 1 part of ceramide, 1 part of arbutin, 2 parts of cetostearyl alcohol, and 8 parts of water. The laminarin butyrate is prepared by Example 1. The specific preparation process of the skin care lotion is as follows: Ⅰ. Put astaxanthin, glutathione, carnosine and Centella asiatica extract into a stirring container and stir thoroughly for 10 minutes to obtain a mixture A; II. In a cool and sterile environment, add biotin, vitamin A alcohol, niacinamide, ceramide, arbutin and cetostearyl alcohol to mixture A and stir evenly, and divide propylene glycol and polyethylene glycol into 3 equal parts and add them respectively during stirring to obtain mixture B; III. dissolving laminarin butyrate in water to obtain liquid C; IV. Mix the mixture B and liquid C, filter them to obtain the skin care lotion of this embodiment, and store them in a sterile refrigerator.

[0048] Example 7: Prepare No. 2 skin care lotion.

[0049] The raw materials of No. 2 skin care lotion include, by weight: 30 parts of propylene glycol, 1 part of polyethylene glycol, 30 parts of laminarin butyrate, 15 parts of glutathione, 10 parts of astaxanthin, 0.8 parts of carnosine, 5 parts of Centella asiatica extract, 10 parts of biotin, 8 parts of vitamin A alcohol, 4 parts of niacinamide, 5 parts of ceramide, 3 parts of arbutin, 1 part of cetostearyl alcohol, and 4 parts of water. The laminarin butyrate is prepared by Example 1. The preparation process of No. 2 skin care lotion is the same as that of No. 1 skin care lotion.

[0050] Example 8: Prepare No. 3 skin care lotion.

[0051] The raw materials of No. 2 skin care lotion include, by weight: 60 parts of propylene glycol, 3 parts of polyethylene glycol, 10 parts of laminarin butyrate, 1 part of glutathione, 1 part of astaxanthin, 15 parts of carnosine, 15 parts of Centella asiatica extract, 1 part of biotin, 1 part of vitamin A alcohol, 1 part of niacinamide, 1 part of ceramide, 0.1 part of arbutin, 3 parts of cetostearyl alcohol, and 15 parts of water. The laminarin butyrate is prepared in Example 1. The preparation process of No. 3 skin care lotion is the same as that of No. 1 skin care lotion.

[0052] Comparative Example 1: Preparation of control emulsion No. 1.

[0053] The raw materials of the control emulsion No. 1 include, by weight: 60 parts of propylene glycol, 3 parts of polyethylene glycol, 10 parts of laminarin butyrate, 1 part of glutathione, 1 part of astaxanthin, 15 parts of carnosine, 15 parts of green tea extract, 1 part of biotin, 1 part of vitamin A alcohol, 1 part of nicotinamide, 1 part of ceramide, 0.1 part of arbutin, 3 parts of cetostearyl alcohol, and 15 parts of water; wherein, laminarin butyrate is prepared by Example 1. The raw material ratio is that the Centella asiatica extract is replaced by an equal amount of green tea extract, and the rest is the same as Example 8. The specific preparation process is as follows: Ⅰ. Put astaxanthin, glutathione, carnosine and green tea extract into a stirring container and stir thoroughly for 10 minutes to obtain a mixture A; II. In a cool and sterile environment, add biotin, vitamin A alcohol, niacinamide, ceramide, arbutin and cetostearyl alcohol to mixture A and stir evenly, and divide propylene glycol and polyethylene glycol into 3 equal parts and add them respectively during stirring to obtain mixture B; III. dissolving laminarin butyrate in water to obtain liquid C; IV. Mix the mixture B and liquid C, filter them to obtain the skin care lotion of this comparative example, and store them in a sterile refrigerator.

[0054] Comparative Example 2: Preparation of control emulsion No. 2.

[0055] The raw materials of the No. 2 control lotion include, by weight: 40 parts of propylene glycol, 2 parts of polyethylene glycol, 8 parts of glutathione, 6 parts of astaxanthin, 5 parts of carnosine, 5 parts of Centella asiatica extract, 6 parts of biotin, 3 parts of vitamin A alcohol, 2 parts of niacinamide, 1 part of ceramide, 1 part of arbutin, 2 parts of cetostearyl alcohol, and 28 parts of water. The raw material ratio is that the butyric laminarin in the No. 1 skin care lotion is replaced by an equal amount of water, and the rest is the same as in Example 6. The specific preparation process is the same as the preparation process of the No. 1 skin care lotion except for the butyric laminarin part.

[0056] Comparative Example 3: Preparation of control composition No. 3.

[0057] According to parts by weight, 20 parts of the butyrate laminarin prepared in Example 1 were dissolved in the same volume of water as the skin care lotion in Example 7 to prepare control composition No. 3.

[0058] Example 9: A patch test was performed on No. 1 to No. 3 skin care lotions.

[0059] 0.1 g of No. 1 to 3 skin care lotion was dripped onto the filter paper, and then the filter paper was placed in the spot tester hole to obtain the test sample. A blank control sample was set for each test sample, that is, 0.1 g of distilled water was dripped onto the filter paper, and then the filter paper was placed in the spot tester hole for control to obtain the control sample.

[0060] 30 volunteers aged 18 to 60 with no serious skin damage were randomly selected. The flexor side of both forearms was used as the test area, and the spot tester was fixed and applied to the flexor side of both forearms of the volunteers using non-irritating tape (the left arm was the test sample, and the right arm was the control sample). The test period was 24 hours. In order to ensure the accuracy, credibility and scientificity of the test results, the volunteers could not remove the spot tester during the test, nor could they allow the test area to come into contact with water.

[0061] After 24 hours, the spot tester was removed, and the indentation was allowed to disappear. The skin reaction was observed according to the standards in Table 2, and the observation results were recorded. The results are shown in Table 3.

[0062]

[0063]

[0064] It can be seen from Table 3 above that no adverse reactions were found in the skin care lotions No. 1 to No. 3 in the test, indicating that the skin care lotion containing laminarin butyrate provided by the present invention has high safety.

[0065] Example 10: The performance of No. 1 to 3 skin care lotions, No. 1 to 2 control lotions and No. 3 control composition were measured.

[0066] 60 male and 60 female subjects aged 18 to 60 with dry skin and obvious damage were randomly selected. They were randomly divided into 6 groups, with 10 males and 10 females in each group. The 6 groups used No. 1 to 3 skin care lotions and No. 1 to 2 control lotions and No. 3 control composition respectively. The method of use was to use it after cleansing every day, once a day, and the experimental period was 20 days. The trial evaluation form was filled out according to the sensory evaluation. Statistics were taken on the 2nd, 5th, 10th, 15th and 20th days of use. The statistical results of the human trial evaluation are shown in Table 4.

[0067]

[0068] As can be seen from the results in Table 4, the skin care lotion containing laminarin butyrate provided by the present invention has significant effects in moisturizing, brightening, whitening and repairing skin barrier, and has a fast onset of action. The skin care lotion is comfortable to use and has no irritation. It not only has significant effects in moisturizing, brightening, whitening and repairing skin barrier, but also makes the skin healthy and clear after use.

[0069] Example 11, specific clinical test case.

[0070] [1] Chen, female, 26 years old, had red, dry, yellowish and dull skin before use. After using the skin care lotion of the present invention for 10 days, her skin became delicate, smooth, tender and elastic, and her skin was fair and rosy.

[0071] [2] Mr. Wang, male, 31 years old, had rough, dry and dark skin before use. After using the skin care lotion of the present invention for 15 days, his skin became smooth, moisturized and his complexion became healthy and clear.

[0072] [3] Ms. Liu, female, 39 years old, had sun spots on her face, rough skin, and wrinkles at the corners of her eyes and mouth before use; after using the skin care lotion of the present invention for 20 days, the spots and wrinkles on her face faded, and her skin tone became moist and shiny.

[0073] In summary, the skin care lotion containing laminarin butyrate provided by the present invention has high safety. Due to the presence of laminarin butyrate, it has the advantages of strong antioxidant and anti-tyrosinase activity, and due to the synergistic effect of laminarin butyrate and Centella asiatica extract, it has strong moisturizing, brightening, whitening, anti-aging, skin barrier repair and other effects.

[0074] The above is only a preferred embodiment of the present invention. The present invention is not limited to the above implementation. As long as the technical effect of the present invention is achieved by the same means, it should belong to the protection scope of the present invention. Within the protection scope of the present invention, its technical scheme and / or implementation method can have various modifications and changes.

Claims

1. A skin care lotion containing laminarin butyrate, characterized in that: The raw materials include, by weight: 35-45 parts of propylene glycol, 2-3 parts of polyethylene glycol, 15-25 parts of laminarin butyrate, 2-12 parts of glutathione, 3-10 parts of astaxanthin, 2-10 parts of carnosine, 4-8 parts of Centella asiatica extract, 3-8 parts of biotin, 1-4 parts of vitamin A alcohol, 1-2 parts of niacinamide, 1-2 parts of ceramide, 0.5-2 parts of arbutin, 1-2 parts of cetostearyl alcohol, and 5-10 parts of water; The butyrate laminarin is prepared by the following steps: (1) vacuum drying the laminarin powder to obtain a dry solid product; (2) adding the solid product to a solution of trifluoroacetic anhydride and butyric acid, and allowing the mixture to fully react to obtain a reaction solution; (3) adding distilled water to the reaction solution and centrifuging, removing the supernatant, and drying the precipitate to obtain a residue; (4) re-dissolving the residue with distilled water; (5) The reconstituted solution obtained in step (4) is dialyzed and freeze-dried to obtain butyrate laminarin.

2. The skin care lotion according to claim 1, characterized in that: In step (1), the laminarin powder is dried under vacuum at 70-80° C. for 1-2 hours.

3. The skin care lotion according to claim 1, characterized in that: In step (2), the mass volume ratio of the solid product to trifluoroacetic anhydride and butyric acid solution is 1 g: (35-45) mL: (10-15) mL.

4. The skin care lotion according to claim 1, characterized in that: In step (2), the reaction conditions of the mixture are stirring at 50±5° C. for 0.5 to 2 hours.

5. The skin care lotion according to claim 1, characterized in that: In step (3), the volume ratio of the reaction solution to distilled water is 1:(3-5).

6. The skin care lotion according to claim 1, characterized in that: In step (3), the centrifugation condition is 8000-10000 rpm for 10-15 minutes.

7. The skin care lotion according to claim 1, characterized in that: In step (3), the drying condition for the precipitate is 60±10° C. for 1 to 4 hours.

8. The skin care lotion according to claim 1, characterized in that: In step (4), the mass ratio of the residue to distilled water is 1:(10-20).

9. The skin care lotion according to claim 1, characterized in that: In step (5), the dialysis condition is to use a dialysis bag with a molecular weight cutoff of 1.4 kDa, place the reconstituted solution in the dialysis bag, and dialyze for at least 24 hours.

10. The method for preparing the skin care lotion according to any one of claims 1 to 9, characterized in that: The method comprises the following steps: mixing glutathione, astaxanthin, carnosine and Centella asiatica extract to obtain mixture A; adding biotin, vitamin A alcohol, niacinamide, ceramide, arbutin and cetostearyl alcohol to the mixture A and stirring evenly, and adding propylene glycol and polyethylene glycol in batches during stirring to obtain mixture B; dissolving butyric laminarin in water to obtain liquid C; and finally mixing the mixture B and the liquid C to obtain the skin care lotion.

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