Granular traditional Chinese medicine composition for treating skin itch and preparation method thereof

Abstract

The invention relates to the technical field of pharmacy, and discloses a skin itch granular traditional Chinese medicine composition and a preparation method thereof.The skin itch granular traditional Chinese medicine composition is prepared from safflower, solanum lyratum, fructus xanthii, ligusticum wallichii, fructus kochiae, liquorice, dendrobe, folium mori, yam rhizome, radix ophiopogonis, a gluconic acid aqueous solution and a pH value regulator. According to the skin itch granule traditional Chinese medicine composition and the preparation method thereof, radix ophiopogonis and propolis are added in the production process of the skin itch granule traditional Chinese medicine composition, the taste and sweetness of the traditional Chinese medicine composition can be guaranteed, the eating comfort of a patient can be improved, meanwhile, the effects of tonifying yin, promoting salivation, moistening the lung, nourishing yin, clearing away the heart-fire, soothing the nerves and promoting gastrointestinal motility can be achieved, and the skin itch effect is improved. The traditional Chinese medicine composition for treating skin itch helps gastric mucosa repair and food digestion, and relieves the pruritus feeling of patients, so that the traditional Chinese medicine composition for treating skin itch can adapt to patients with gastrointestinal ulcer or poor gastrointestinal digestive ability, and the applicable crowd range of the traditional Chinese medicine composition for treating skin itch is widened.

Description

Technical Field

[0001] The invention relates to the technical field of pharmaceuticals, in particular to a traditional Chinese medicine composition of skin itch granules and a preparation method thereof. Background Art

[0002] Skin pruritus and urticaria are common and frequently occurring diseases in dermatology; they are mainly manifested as unbearable skin itching, rash, and dermatitis, which seriously affect patients' daily work and life. However, there are many Chinese patent medicines for the treatment of skin diseases in the prior art, most of which only treat the symptoms and not the root cause, and the cure rate is poor.

[0003] According to a disclosed Chinese medicine composition of skin itch granules and its preparation method (Announcement No.: CN103961462A), in the above application, the existing process of "letting the decoction stand and precipitate for 8 hours" is changed to "adding ethanol to the decoction and letting it stand and precipitate for 8 hours", so that the prepared skin itch treatment drug will not cause adverse reactions such as nausea and stomach discomfort during long-term use by patients, thereby significantly improving its clinical pharmacodynamic experimental results.

[0004] However, the above-mentioned traditional Chinese medicine composition of itchy skin granules contains safflower for treating itchy skin, but the use of safflower causes certain damage to the patient's stomach and digestive system. In particular, patients with gastric ulcers or gastrointestinal diseases cannot take this medicine or must take it in combination with other gastrointestinal protective drugs, which increases the patient's medication cost to a certain extent. In view of this, we propose a traditional Chinese medicine composition of itchy skin granules and a preparation method thereof. Summary of the invention

[0005] The object of the present invention is to provide a traditional Chinese medicine composition of Fuyang granules and a preparation method thereof, so as to solve the problems raised in the above-mentioned background technology.

[0006] To achieve the above-mentioned purpose, the present invention provides the following technical scheme: a Chinese medicine composition for skin itching granules, comprising the following components: 350-450g safflower, 100-200g white safflower, 350-450g Xanthium sibiricum, 300-400g Chuanxiong, 250-350g Kochia scoparia, 200-300g liquorice, 100-200g dendrobium, 300-500g mulberry leaf, 300-400g Polygonum multiflorum, 100-150g Ophiopogon japonicus, as well as a gluconic acid aqueous solution and a pH regulator.

[0007] A method for preparing the Fuyang granule Chinese medicine composition, based on the Fuyang granule Chinese medicine composition, the preparation method comprises the following steps: S1. First steaming: add water to safflower, white safflower, Xanthium sibiricum, Chuanxiong and Kochia scoparia and steam for 2 hours; S2, secondary steaming: add water to the steaming container of S1, and add liquorice, dendrobium, mulberry leaves and radix ophiopogonis for secondary steaming, add ophiopogon japonicus after the water is boiled, and the second steaming time is 2 hours; S3, concentration and purification, after the steaming in S2 is completed, remove the Chinese medicine residue, and let the solution stand for 15 minutes, then take the supernatant and put it into the steaming container and boil it again over high heat, and repeat 2 to 3 times; S4, preparing the ointment, taking the concentrated and purified drug solution in S3 and placing it in a centrifuge for centrifugation, adding a pH adjuster to adjust the pH value of the solution to 7-7.5, and separating excess water and impurities through a filter, and finally obtaining the ointment; S5, drying and mixing, taking the ointment prepared in S4 and putting it into a sterile dryer for drying to obtain drug powder, and adding propolis and xylitol to the drug powder for mixing; S6, granulation, secondary drying the mixture in S5, and granulating it with a granulator, and packaging to obtain the Fuyang Granule Chinese medicine composition.

[0008] Preferably, the safflower, white safflower, Xanthium sibiricum, Chuanxiong, Kochia scoparia, liquorice, dendrobium, mulberry leaf, Radix Dioscoreae, and Radix Ophiopogonis are all dried medicinal materials, and are dried in the sun before making medicine. The drying humidity is maintained between 45% and 65%, which helps the medicinal materials maintain a stable water content and avoid rotting, deterioration or mildew, and also prevents the medicinal materials from absorbing moisture or being over-dried.

[0009] Preferably, a casserole is used for cooking in S1 and S2, and pure water is added in a weight ratio of 6:1 to the medicine for the first cooking in S1, and the cooking is carried out in a heating method of low heat-medium heat-high heat-medium heat. At the same time, the casserole is in a relatively closed state during the cooking process, and the air is exhausted by relying on the air holes of the casserole lid of the casserole, so that the temperature of the traditional Chinese medicine components rises in a step-by-step manner during the cooking, avoiding damage to the efficacy due to direct high heat, and keeping the medium heat in a boiling state can ensure the water temperature without causing loss of the traditional Chinese medicine components due to high temperature. In addition, by cooking in a relatively closed casserole, the loss of drug components due to steam loss is reduced, thereby improving the efficiency and effect of traditional Chinese medicine cooking and extraction.

[0010] Preferably, when adding water for the second time in S2, the amount of water in the casserole is supplemented to the same level as the pure water added for the first time in S1, and after the water is boiled for the second time, Ophiopogon japonicus is added and the cooking is continued until the casserole is in a boiling state, until the cooking time reaches 2 hours, and the mixture is continuously stirred during the second cooking process, so that the Chinese medicinal materials ingredients of the second cooking can be more evenly dispersed in the cooking solution of the casserole to ensure the effect of the medicinal materials cooking and extraction, and by adding Ophiopogon japonicus, the sweetness can be increased without damaging the gastric mucosal membrane, Ophiopogon japonicus can replenish yin and produce body fluid, moisten the lungs and nourish yin, clear the heart and calm the nerves, and can also promote gastrointestinal motility, help gastric mucosal repair and food digestion, so that the Chinese medicine composition of skin itch granules with Ophiopogon japonicus can be suitable for patients with gastrointestinal ulcers or poor gastrointestinal digestion, thereby improving the range of applicable populations of the Chinese medicine composition of skin itch granules.

[0011] Preferably, when the Chinese medicinal materials are steamed in S1 and S2, they are placed in silica gel mesh bags for steaming, and each kind of medicinal material is contained in a silica gel mesh bag, so that most of the residues of the medicinal materials can be removed conveniently after steaming, and the waste of the steaming liquid can be reduced. At the same time, the mesh bag made of silica gel material has good high temperature resistance, and will not be denatured or damaged under the high temperature state of the steaming liquid, which effectively ensures the effect of steaming and extracting the medicinal materials without causing them to scatter.

[0012] Preferably, the pH regulator is one or more of potassium carbonate, sodium bicarbonate, and disodium hydrogen phosphate, and the pH value in the mixed solution is adjusted to be weakly alkaline, thereby increasing the pH value of the microenvironment, which can change the solubility of the drug, thereby affecting the release rate of the drug. In addition, the weakly alkaline pH regulator also helps to improve the permeability of the Fuyang granule Chinese medicine composition, offset the decrease in solubility caused by the increase in pH in the body, and ensure uniform absorption of the drug in the body.

[0013] Preferably, a drying and mixing all-in-one machine is used for drying in S5, and the drying and mixing all-in-one machine includes a drying component and a mixing component. An ultraviolet sterilization lamp is arranged inside the drying component, and the drying component also includes a circulating extrusion structure. The circulating extrusion structure extrude the ointment prepared in S4, and dries it through continuous irradiation by the ultraviolet sterilization lamp and a heating structure in the drying component. The temperature in the drying component is set between 70°C and 80°C, so that the ointment can be evenly heated during the continuous extrusion process to achieve the drying effect, discharge the moisture inside the ointment, so as to avoid excessive moisture in the subsequently prepared granular Chinese medicine composition and reduce its shelf life.

[0014] Preferably, the mixing component is provided with two groups of feed ports, and one group of feed ports is through-connected with the discharge port of the drying component to feed the dried ointment, and the other group of feed ports is used to feed the propolis and xylitol mixture, and the mixing component is provided with a dispersion component at the feed port corresponding to the ointment, and the interior of the mixing component is provided with a cutting and crushing component, so as to ensure the mixing effect of the ointment, propolis and xylitol. Propolis and xylitol are used as fillers of the traditional Chinese medicine composition of skin itch granules, which can not only improve the taste of the traditional Chinese medicine composition of skin itch granules, but also propolis is a pure natural product, does not contain additives and other ingredients, and xylitol can not only improve the taste, but also does not contain sucrose and the like, and is also suitable for diabetic patients, thereby increasing the applicable population range of the traditional Chinese medicine composition of skin itch granules.

[0015] Preferably, the mixing component is provided with a drying structure, and the heat exchange portion of the drying structure is arranged inside the cutting and rolling component to improve the heat exchange effect between the drying structure and the ointment, propolis and xylitol mixture, and the internal temperature of the mixing component is set at 60-70°C.

[0016] Compared with the prior art, the present invention provides a traditional Chinese medicine composition of Fuyang granules and a preparation method thereof, which has the following beneficial effects: 1. The Chinese medicine composition of Fuyang Granules and its preparation method, by adding Ophiopogon japonicus and propolis in the production process of the Chinese medicine composition of Fuyang Granules, can not only ensure the taste and sweetness of the Chinese medicine composition and improve the patient's eating comfort, but also can replenish yin and produce body fluid, moisten the lungs and nourish yin, clear the heart and calm the nerves, and can also promote gastrointestinal motility, help gastric mucosal repair and food digestion, so that the Chinese medicine composition of Fuyang Granules can be used by patients with gastrointestinal ulcers or poor gastrointestinal digestion ability, thereby increasing the range of applicable populations of the Chinese medicine composition of Fuyang Granules.

[0017] 2. The traditional Chinese medicine composition of the itchy granules and the preparation method thereof adopt one or more of potassium carbonate, sodium bicarbonate and disodium hydrogen phosphate as pH regulators, and adjust the pH value of the cooking liquid to weak alkalinity, thereby changing the solubility of the drug, thereby affecting the release rate of the drug and the permeability of the traditional Chinese medicine composition of the itchy granules, offsetting the decrease in solubility caused by the increase in pH in the body, and ensuring uniform absorption of the drug in the body.

[0018] 3. The Chinese medicine composition for itchy skin granules and its preparation method, by providing a cutting and crushing component in the mixing component during the ointment mixing process, and cooperating with the dispersing component during the ointment feeding, ensures the mixing effect of the ointment, propolis and xylitol, so that the individual particles of the Chinese medicine composition for itchy skin granules have similar tastes during the final granulation, thereby ensuring the product quality of the Chinese medicine composition for itchy skin granules during granulation. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1It is a schematic diagram of the components of the present invention; Figure 2 It is a schematic diagram of the production steps of the Fuyang Granule Chinese medicine composition of the present invention. DETAILED DESCRIPTION

[0020] like Figure 1-Figure 2 As shown, the present invention provides a technical solution: a traditional Chinese medicine composition of skin itching granules and a preparation method thereof, the traditional Chinese medicine composition comprising the following components: 350-450g safflower, 100-200g white safflower, 350-450g Xanthium sibiricum, 300-400g Chuanxiong, 250-350g Kochia scoparia, 200-300g liquorice, 100-200g dendrobium, 300-500g mulberry leaf, 300-400g Polygonum multiflorum, 100-150g Ophiopogon japonicus, as well as a gluconic acid aqueous solution and a pH regulator.

[0021] At the same time, based on the Fuyang granule Chinese medicine composition, the preparation method of the Fuyang granule Chinese medicine composition comprises the following steps: S1. First steaming: add water to safflower, white safflower, Xanthium sibiricum, Chuanxiong and Kochia scoparia and steam for 2 hours; S2, secondary steaming: add water to the steaming container of S1, and add liquorice, dendrobium, mulberry leaves and radix ophiopogonis for secondary steaming, add ophiopogon japonicus after the water is boiled, and the second steaming time is 2 hours; S3, concentration and purification, after the steaming in S2 is completed, remove the Chinese medicine residue, and let the solution stand for 15 minutes, then take the supernatant and put it into the steaming container and boil it again over high heat, and repeat 2 to 3 times; S4, preparing the ointment, taking the concentrated and purified drug solution in S3 and placing it in a centrifuge for centrifugation, adding a pH adjuster to adjust the pH value of the solution to 7-7.5, and separating excess water and impurities through a filter, and finally obtaining the ointment; S5, drying and mixing, taking the ointment prepared in S4 and putting it into a sterile dryer for drying to obtain drug powder, and adding propolis and xylitol to the drug powder for mixing; S6, granulation, secondary drying the mixture in S5, and granulating it with a granulator, and packaging to obtain the Fuyang Granule Chinese Medicine Composition In one embodiment of the present invention, safflower, white safflower, Xanthium sibiricum, Chuanxiong, Kochia scoparia, liquorice, dendrobium, mulberry leaf, Radix Dioscoreae, and Radix Ophiopogonis are all dried medicinal materials, and are dried in the sun before making medicine. The drying humidity is maintained between 45% and 65%, which helps the medicinal materials maintain a stable water content and avoid rotting, deterioration or mildew, and also prevents the medicinal materials from absorbing moisture or being over-dried.

[0022] In addition, a casserole is used for steaming in S1 and S2, and pure water is added in a weight ratio of 6:1 to the medicine for the first steaming in S1, and the steaming is carried out in a heating method of low heat-medium heat-high heat-medium heat. At the same time, the casserole is in a relatively closed state during the steaming process, and the air is exhausted by relying on the air holes of the casserole lid of the casserole, so that the temperature of the Chinese medicine ingredients rises in a step-by-step manner during the steaming, avoiding the damage of the efficacy due to direct high heat, and keeping the medium heat in a boiling state can ensure the water temperature without causing loss of the Chinese medicine ingredients due to high temperature. In addition, by steaming in a relatively closed casserole, the loss of drug ingredients caused by steam loss is reduced, thereby improving the efficiency and effect of steaming and extraction of Chinese medicine. Specifically, when adding water for the second time in S2, the casserole in the casserole is The amount of water is added to be consistent with the height of the pure water added for the first time in S1, and after the water is boiled for the second time, add Ophiopogon japonicus and continue to cook until the casserole is boiling, until the cooking time reaches 2 hours, and stir continuously during the second cooking process, so that the Chinese medicinal materials ingredients of the second cooking can be dispersed more evenly in the cooking solution of the casserole to ensure the effect of the medicinal materials cooking and extraction, and by adding Ophiopogon japonicus, the sweetness can be increased without damaging the gastric mucosal membrane. Ophiopogon japonicus can replenish yin and produce fluid, moisten the lungs and nourish yin, clear the heart and calm the nerves, and can also promote gastrointestinal motility, help gastric mucosal repair and food digestion, so that the Chinese medicine composition of skin itch granules with Ophiopogon japonicus can be suitable for patients with gastrointestinal ulcers or poor gastrointestinal digestion, thereby improving the range of applicable populations of the Chinese medicine composition of skin itch granules.

[0023] In an embodiment of the present invention, when steaming in S1 and S2, the Chinese medicinal materials are placed in a silica gel mesh bag for steaming, and each kind of medicinal material is contained in a silica gel mesh bag, so that most of the residues of the medicinal materials can be removed conveniently after steaming, and the waste of the steaming liquid can be reduced. At the same time, the mesh bag made of silica gel material has good high temperature resistance, and will not be denatured or damaged under the high temperature state of the cooking liquid, which effectively ensures the effect of the hot steaming and extraction of the medicinal materials without any scattering. Furthermore, the pH adjuster adopts one or more combinations of potassium carbonate, sodium bicarbonate, and disodium hydrogen phosphate to adjust the pH value in the mixed solution to be weakly alkaline, thereby increasing the pH value of the microenvironment, which can change the solubility of the drug, thereby affecting the release rate of the drug. In addition, the weakly alkaline pH adjuster also helps to improve the permeability of the skin itching granule Chinese medicine composition, offset the decrease in solubility caused by the increase in pH in the body, and ensure the uniform absorption of the drug in the body.

[0024] In the present invention, a drying and mixing all-in-one machine is used for drying in S5, and the drying and mixing all-in-one machine includes a drying component and a mixing component. An ultraviolet sterilization lamp is arranged inside the drying component, and the drying component also includes a circulating extrusion structure. The circulating extrusion structure squeezes out the ointment prepared in S4, and dries it through continuous irradiation by the ultraviolet sterilization lamp and a heating structure in the drying component. The temperature in the drying component is set between 70°C and 80°C, so that the ointment can be evenly heated during the continuous extrusion process to achieve the drying effect, discharge the moisture inside the ointment, and avoid excessive moisture in the subsequently prepared granular Chinese medicine composition and reduce its shelf life.

[0025] It is worth noting that there are two groups of feed ports of the mixing component, and one group of feed ports is connected with the discharge port of the drying component to feed the dried ointment, and the other group of feed ports is used to feed the propolis and xylitol mixture, and a dispersion component is provided at the feed port of the mixing component corresponding to the ointment, and a cutting and rolling component is provided inside the mixing component to ensure the mixing effect of the ointment, propolis and xylitol. Propolis and xylitol are used as fillers of the skin itch granule Chinese medicine composition, which can not only improve the taste of the skin itch granule Chinese medicine composition, but also propolis is a pure natural product without additives and other ingredients, and xylitol can not only improve the taste, but also does not contain sucrose and the like, and is also suitable for diabetic patients, thereby increasing the applicable population range of the skin itch granule Chinese medicine composition, and at the same time, the mixing component is provided with a drying structure, and the heat exchange part of the drying structure is arranged inside the cutting and rolling component to improve the heat exchange effect between the drying structure and the ointment, propolis and xylitol mixture, and the internal temperature of the mixing component is set at 60°C to 70°C.

[0026] The above generally describes the present invention in detail, but it is obvious to a person skilled in the art that some modifications or improvements can be made to the present invention. Therefore, modifications or improvements that do not depart from the spirit of the present invention are within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for itching granules, characterized in that: The traditional Chinese medicine composition comprises the following components: 350-450g of safflower, 100-200g of white peony root, 350-450g of Xanthium sibiricum fruit, 300-400g of Chuanxiong, 250-350g of Kochia scoparia fruit, 200-300g of liquorice, 100-200g of dendrobium, 300-500g of mulberry leaf, 300-400g of Polygonum multiflorum, 100-150g of Ophiopogon japonicus, as well as a gluconic acid aqueous solution and a pH regulator.

2. A method for preparing a traditional Chinese medicine composition of Fuyang granules, characterized in that: Based on the Fuyang granule Chinese medicine composition according to claim 1, the preparation method comprises the following steps: S1. First steaming: add water to safflower, white safflower, Xanthium sibiricum, Chuanxiong and Kochia scoparia and steam for 2 hours; S2, secondary steaming: add water to the steaming container of S1, and add liquorice, dendrobium, mulberry leaves and radix ophiopogonis for secondary steaming, add ophiopogon japonicus after the water is boiled, and the second steaming time is 2 hours; S3, concentration and purification, after the steaming in S2 is completed, remove the Chinese medicine residue, and let the solution stand for 15 minutes, then take the supernatant and put it into the steaming container and boil it again over high heat, and repeat 2 to 3 times; S4, preparing the ointment, taking the concentrated and purified drug solution in S3 and placing it in a centrifuge for centrifugation, adding a pH adjuster to adjust the pH value of the solution to 7-7.5, and separating excess water and impurities through a filter, and finally obtaining the ointment; S5, drying and mixing, taking the ointment prepared in S4 and putting it into a sterile dryer for drying to obtain drug powder, and adding propolis and xylitol to the drug powder for mixing; S6, granulation, secondary drying the mixture in S5, and granulating it with a granulator, and packaging to obtain the Fuyang Granule Chinese medicine composition.

3. The method for preparing a traditional Chinese medicine composition of Fuyang granules according to claim 2, characterized in that: The safflower, white safflower, Xanthium sibiricum, Chuanxiong, Kochia scoparia, liquorice, dendrobium, mulberry leaf, Dioscorea paniculata, and Ophiopogon japonicus are all dried medicinal materials, and are dried in the sun before being made into medicine, and the drying humidity is maintained between 45% and 65%.

4. The method for preparing a traditional Chinese medicine composition of Fuyang granules according to claim 2, characterized in that: A casserole is used for cooking in S1 and S2, and pure water is added in a weight ratio of 6:1 to the medicine during the first cooking in S1, and the cooking is carried out in a heating method of low heat-medium heat-high heat-medium heat. At the same time, the casserole is in a relatively closed state during the cooking process, and exhaust is carried out by relying on the air holes of the casserole cover provided by the casserole.

5. The method for preparing a traditional Chinese medicine composition of Fuyang granules according to claim 4, characterized in that: When adding water for the second time in S2, the amount of water in the casserole is supplemented to the same level as the pure water added for the first time in S1, and after the water is boiled for the second cooking, add Ophiopogon japonicus and continue cooking until the casserole is boiling, until the cooking time reaches 2 hours, and stir continuously during the second cooking process.

6. The method for preparing a traditional Chinese medicine composition of Fuyang granules according to claim 2, characterized in that: When the Chinese medicinal materials are steamed in S1 and S2, they are all placed in silica gel mesh bags for steaming, and each medicinal material is contained in a silica gel mesh bag.

7. The method for preparing a traditional Chinese medicine composition of Fuyang granules according to claim 2, characterized in that: The pH value regulator is one or a combination of potassium carbonate, sodium bicarbonate and disodium hydrogen phosphate to adjust the pH value in the mixed solution to be weakly alkaline.

8. The method for preparing a traditional Chinese medicine composition of Fuyang granules according to claim 2, characterized in that: When drying is performed in S5, a drying and mixing integrated machine is used, and the drying and mixing integrated machine includes a drying component and a mixing component. An ultraviolet sterilization lamp is arranged inside the drying component, and the drying component also includes a circulating extrusion structure. The circulating extrusion structure squeezes out the ointment prepared in S4 and dries it through continuous irradiation of the ultraviolet sterilization lamp and a heating structure in the drying component. The temperature in the drying component is set between 70°C and 80°C.

9. The method for preparing a traditional Chinese medicine composition of Fuyang granules according to claim 8, characterized in that: The mixing component is provided with two groups of feed ports, and one group of feed ports is through-connected with the discharge port of the drying component to feed the dried ointment, and the other group of feed ports is used to feed the propolis and xylitol mixture. In addition, the mixing component is provided with a dispersing component at the feed port corresponding to the ointment, and a cutting and crushing component is provided inside the mixing component.

10. The method for preparing a traditional Chinese medicine composition of Fuyang granules according to claim 9, characterized in that: The mixing component is provided with a drying structure, and the heat exchange part of the drying structure is arranged inside the cutting and rolling component to improve the heat exchange effect between the drying structure and the ointment, propolis and xylitol mixture, and the internal temperature of the mixing component is set at 60°C to 70°C.

Images