Preparation process of wine-processed propolis traditional Chinese medicine decoction pieces

Abstract

The invention discloses a preparation process of wine-processed propolis traditional Chinese medicine decoction pieces, which comprises the following steps: (1) dissolving and extracting a raw material propolis with an ethanol water solution to obtain a propolis liquid; (2) filtering the propolis liquid through a plate frame, recovering ethanol, and collecting propolis extract; (3) the propolis extract is dripped and formed by a pill dropping machine, the wine-processed propolis traditional Chinese medicine decoction pieces are obtained, and the technological parameters of the pill dropping machine are as follows: the dripping temperature is 105-135 DEG C, the pipe orifice temperature is 50-70 DEG C, the coolant temperature is less than or equal to 10 DEG C, the dripping distance is 3-6 cm, and the coolant is dimethyl silicone oil. The problem of coolant residue in the decoction pieces and the problem of adhesion of the decoction pieces can be well solved.

Description

Technical Field

[0001] The invention belongs to the technical field of Chinese medicinal pieces, and in particular relates to a preparation process of wine-made propolis Chinese medicinal pieces. Background Art

[0002] According to the Chinese Pharmacopoeia, propolis is a sticky solid colloid formed by the plant resin collected by the worker bees of the family Apis mellifera L. and the secretions of their maxillary glands, wax glands, etc. It is mostly collected from beehives in summer and autumn to remove impurities. Propolis gradually becomes hard and brittle below 20°C, gradually softens at 20-40°C, becomes sticky and plastic, and is stored at -4°C. Wine-made propolis is a processed product of propolis. The processing method is: take propolis and crush it, soak and dissolve it in ethanol, filter it, recover ethanol from the filtrate, and dry it. Propolis and wine-made propolis have the effects of replenishing weakness, removing turbid fat, and stopping thirst; external use has the effects of detoxification and swelling, astringency and muscle regeneration. Clinically used for physical weakness, premature aging, hyperlipidemia, thirst, and external treatment of skin chapped skin and burns.

[0003] Drop-molding is a common molding method in the preparation process of wine-made propolis, and the Chinese herbal medicine slices made from it are easy to take and store. Unlike the common propolis drop pills on the market, most of which need to be added with a matrix (such as polyethylene glycol) before they can be drop-molded, wine-made propolis, as a Chinese herbal medicine slice, cannot be added with any matrix or other additional materials, so the molding process of wine-made propolis is more difficult.

[0004] The coolants (such as dimethyl silicone oil, liquid paraffin, etc.) used in the process of dripping and molding wine-made propolis are easy to remain in the propolis slices. Although these coolants are generally food grade, the coolant residues still affect the quality of the slices (such as purity issues, affecting the release of medicinal effects of the slices, compatibility, etc.). In addition, the residues of liquid coolants in wine-made propolis slices also increase the physical force between the slices. Coupled with the viscosity of propolis itself, the wine-made propolis slices are more likely to stick together, which is not conducive to the dispersion of the slices. Secondly, it is easy to stick to the surface of the equipment, causing the loss of the slices, and it is also not conducive to equipment cleaning.

[0005] Conventional centrifugal drying is used in existing production. Although it can remove some residual coolant on the surface of wine-made propolis slices to a certain extent, propolis is soft at room temperature, and this mechanical method is easy to damage the integrity and appearance of wine-made propolis slices; if centrifugal operation is performed at low temperature, the hardness of propolis can be increased, but the coolant becomes more difficult to remove from the surface of the slices as the viscosity increases at low temperature. Small-scale products directly use cloth, filter paper or ordinary oil-absorbing paper to wipe the coolant on the surface of wine-made propolis slices, but these materials usually stick to part of the propolis and cause propolis loss, and sometimes damage the wine-made propolis slices due to personal problems.

[0006] In summary, how to provide a preparation process for wine-processed propolis Chinese medicine slices, reduce the coolant residue in the slices and prevent the slices from sticking together is an urgent problem to be solved. Summary of the invention

[0007] The purpose of the present invention is to overcome the shortcomings of the prior art and provide a preparation process of wine-made propolis Chinese medicine slices, which can better solve the problems of coolant residue in the slices and the adhesion of the slices.

[0008] The types of coolants remaining in wine-made propolis Chinese medicine slices can be divided into coolants with strong binding properties and surface free coolants according to their existence forms. The coolants with strong binding properties have a strong interaction with the Chinese medicine slices and are difficult to remove, while the free coolants have a weak interaction with the Chinese medicine slices and are easier to remove. Therefore, in order to solve the problem of coolant residues in the slices, the coolant residues with strong binding properties in the slices should be reduced first.

[0009] In the molding process of wine-made propolis Chinese herbal medicine slices, when the heated propolis droplets are dripped into the coolant, the huge temperature difference causes the propolis droplets to shrink rapidly. During the shrinkage process, they are easily affected by the process parameters, resulting in uneven shrinkage. The coolant is easily entrained into the propolis droplets, resulting in a large amount of highly bound coolant remaining in the propolis slices.

[0010] The first purpose of the present invention is to improve the quality of the propolis slices by optimizing the process parameters of propolis drip molding, and at the same time, to control the shrinkage of the propolis droplets when the coolant (dimethyl silicone oil) is dripped into the propolis slices through the process parameters, thereby effectively reducing the content of the coolant with strong binding in the wine-made propolis slices during molding.

[0011] To achieve the first purpose, the technical solution adopted by the present invention is: A preparation process of wine-processed propolis Chinese medicinal slices comprises the following steps: (1) dissolving and extracting raw propolis with ethanol aqueous solution to obtain propolis liquid; (2) filtering the propolis liquid through a plate and frame, recovering ethanol, collecting the propolis extract, and vacuum drying it at 50-60°C; (3) The propolis product obtained in step (2) is dripped into a pill machine (0.1 g / pill or 0.2 g / pill) to obtain wine-made propolis Chinese medicinal slices. The process parameters of the pill machine include: dripping temperature of 115-130° C., nozzle temperature of 50-70° C., coolant temperature of 0-6° C., dripping distance (the distance from the dripper to the coolant liquid surface) of 4-5 cm, and the coolant used is dimethyl silicone oil, and the viscosity of the dimethyl silicone oil is 350-750 cst.

[0012] Preferably, in step (1), the extraction temperature is 40-60°C, the extraction time is 24-48 hours, the volume concentration of the ethanol aqueous solution is 70-95%, and the amount used is 1-6 times the mass of the raw propolis.

[0013] Preferably, in step (2), the relative density of the propolis extract is 1.1-1.3.

[0014] Preferably, in step (3), the dripping speed is 25-35 drops / min, and the amount of coolant used is 15-50 times that of propolis extract, and more preferably 20-30 times.

[0015] The second object of the present invention is to replace the high viscosity (free state) coolant dimethyl silicone oil adhering to the surface of the wine-made propolis slices with low viscosity dimethyl silicone oil, and this low viscosity dimethyl silicone oil is easier to remove.

[0016] To achieve the second purpose, preferably, step (3) comprises: dripping the propolis extract into a pill machine, washing the obtained propolis product 1-3 times with dimethyl silicone oil having a temperature of 5-10°C and a viscosity of 20-100 cst, and then filtering to obtain wine-made propolis Chinese herbal medicine slices, and the process parameters of the pill machine include: dripping temperature of 115-130°C, nozzle temperature of 50-70°C, coolant temperature of 0-6°C, dripping distance of 4-5 cm, and the coolant used is dimethyl silicone oil with a viscosity of 350-750 cst.

[0017] The third object of the present invention is to use a specific adsorption material to remove the (free) coolant dimethyl silicone oil adhering to the surface of the wine-made propolis slices without destroying the integrity and appearance of the propolis slices, and can also reduce the adhesion problem between the slices.

[0018] To achieve the third purpose, the technical solution adopted by the present invention is: For the above-prepared wine-made propolis Chinese medicinal slices, a grapefruit peel material is used to remove the coolant remaining in the slices. The preparation method of the grapefruit peel material comprises the following steps: S1. Wash, dry and sterilize the grapefruit peel, and then crush it into grapefruit peel particles for later use; S2, dissolving corn protein in an ethanol aqueous solution, then adding grapefruit peel particles, stirring evenly and soaking for 3-20 minutes, and then evaporating the solvent (ethanol and water) to obtain treated grapefruit peel particles; S3. After boiling the tamarind gum solution for 20-30 minutes, add the treated grapefruit peel particles, mix evenly, and then press into a sheet at 0.05-0.2 MPa, and then dry at 80-90° C. for 1-4 hours to obtain the grapefruit peel material.

[0019] Preferably, in step S1, the particle size of the grapefruit peel particles is 30-100 mesh; in step S2, the mass ratio of corn protein to grapefruit peel particles is (0.02-0.08):1, the volume concentration of the ethanol aqueous solution is 85-90%, and its usage is 5-50 times that of corn protein.

[0020] Preferably, in step S3, the mass ratio of tamarind gum to the treated grapefruit peel particles is (0.05-0.1):1, and the mass concentration of the tamarind gum aqueous solution is 10-20 g / L.

[0021] Preferably, the method of using grapefruit peel material to remove the coolant remaining in the medicinal slices includes: cutting the grapefruit peel material, laying it in a rotatable container (a high-efficiency coating pot can be selected), and then directly introducing the propolis Chinese medicinal slices obtained in the pill machine into the rotatable container, and rotating it at 5-20r / min for 10-20min.

[0022] It is worth noting that in the above content: The dimethyl silicone oil with strong binding properties in propolis slices refers to the part of dimethyl silicone oil that has a strong binding effect with the slices, low fluidity, and is not easily removed by conventional mechanical means (such as centrifugation).

[0023] The free coolant dimethyl silicone oil adhering to the surface of wine-processed propolis slices refers to the part of dimethyl silicone oil that has a weaker binding effect with the slices, stronger fluidity and freedom, and can be easily removed by conventional mechanical means (such as centrifugation).

[0024] Technical effects of the present invention: 1. The preparation process of the wine-made propolis Chinese medicinal slices of the present invention is simple to operate and can achieve better pellet forming without introducing any external substances. The present invention can improve the comprehensive quality of the propolis slices by optimizing the molding process parameters during the preparation of the wine-made propolis Chinese medicinal slices.

[0025] 2. In the molding process of the wine-made propolis Chinese medicinal slices of the present invention, the shrinkage of the propolis droplets when the coolant dimethyl silicone oil is added can be further controlled by controlling the molding process parameters (relative density of propolis extract + dripping distance + dripping temperature + coolant temperature + coolant viscosity), thereby reducing the content of dimethyl silicone oil with strong binding in the propolis slices during molding.

[0026] The temperature difference encountered when propolis is dripped into the coolant determines the degree of shrinkage of the droplets, and the dripping distance determines the shape of the propolis droplets when dripped (if the dripping distance is too small, the droplets will not have time to shrink into a circle and will start to cool, making the droplets shrink unevenly during cooling; if the dripping distance is too large, the droplets will be easily broken and the roundness will be insufficient, and the shrinkage will also be uneven). The relative density of propolis extract and the viscosity of the coolant determine the falling speed of the propolis droplets in the coolant (if the drop is too fast, the propolis will not be cooled completely and the droplets will shrink too quickly; if the drop is too slow, not only will the droplets be easy to stick together, but the droplets will also shrink too slowly). When these parameters are appropriate, the propolis droplets can shrink evenly in the coolant, reducing the possibility of the coolant being entrained in the droplets. The content of coolant with strong binding properties in the propolis slices (not easy to remove) can be reduced from the molding process stage, so that most of the coolant on the surface of the propolis slices exists in a free state, which is easier to remove.

[0027] 3. The present invention also uses low-viscosity dimethyl silicone oil to clean propolis after drop molding. Firstly, the low-viscosity dimethyl silicone oil replaces the high-viscosity dimethyl silicone oil used during cooling, which can reduce the free dimethyl silicone oil content on the surface of propolis slices (low-viscosity dimethyl silicone oil has a relatively low density, which is not only not easy to adhere to the surface of propolis, but also has a smaller weight of adhered low-viscosity dimethyl silicone oil under the same adsorption volume); secondly, the low-viscosity dimethyl silicone oil contained on the surface of propolis is easier to be removed by the subsequent adsorption material-grapefruit peel material.

[0028] 4. The present invention uses grapefruit peel material to remove the coolant dimethyl silicone oil from propolis slices. Specifically, the grapefruit peel material is cut and laid in a rotatable container, and then the propolis slices obtained in the pill dropping machine are directly introduced into the rotatable container, and then the container is rotated at a low speed. Grapefruit peel is a green and environmentally friendly material. Its sponge structure contains rich pores, which can effectively absorb and remove dimethyl silicone oil on the surface of propolis slices without destroying the integrity and roundness of the propolis slices.

[0029] The hydrophobicity of pure grapefruit peel is not enough, and the material is too soft, which is not conducive to the turning of propolis slices in the process of removing dimethyl silicone oil. Therefore, when preparing grapefruit peel material, the present invention first uses corn gluten to treat grapefruit peel particles and then uses tamarind gum for bonding. Corn gluten contains a large amount of hydrophobic amino acids, which can form a hydrophobic film on the surface of grapefruit peel particles, which can not only reduce the water absorption of grapefruit peel in the aqueous solution of the subsequent step S3, but also improve the adsorption of hydrophobic dimethyl silicone oil by grapefruit peel. Tamarind gum, as a highly viscous polysaccharide, can interact with corn gluten (essentially protein), improve the compatibility of tamarind gum binder with grapefruit peel, and strengthen the coagulation strength of tamarind gum.

[0030] 5. The softness and elasticity of grapefruit peel material will affect the properties of propolis slices and the removal of dimethyl silicone oil. When grapefruit peel material is too soft, it is not conducive to turning over the propolis slices during the removal of dimethyl silicone oil, and it is easy for propolis to adhere to the grapefruit peel material and cause propolis loss; when grapefruit peel material is not soft enough, it is not conducive to the grapefruit peel material to absorb dimethyl silicone oil on the surface of propolis slices, and it is also easy to damage the appearance of propolis slices. When grapefruit peel material is not elastic enough, it is also easy to damage the appearance of propolis slices; when grapefruit peel material is too elastic, it is not conducive to the contact between grapefruit peel material and propolis dripping pills.

[0031] Therefore, the present invention combines corn protein with tamarind gum to provide appropriate softness and elasticity for the grapefruit peel material, comprehensively improve the removal rate of dimethyl silicone oil, ensure the appearance (mainly roundness) of the propolis slices and reduce the loss of propolis.

[0032] 6. In addition, in the prior art, the removal of dimethyl silicone oil from the surface of propolis slices is likely to cause damage to the surface of the slices. When the surface of the propolis slices is damaged or the roundness is insufficient, the slices are very likely to stick together. The present invention uses grapefruit peel material to perform a relatively gentle treatment on the propolis slices to remove the dimethyl silicone oil, thereby reducing the physical force between the slices that is increased by the residual liquid coolant dimethyl silicone oil in the wine-made propolis slices, and will not affect the surface integrity and roundness of the slices. Therefore, the propolis slice products treated by the present invention are not prone to adhesion. DETAILED DESCRIPTION

[0033] The above scheme is further described below in conjunction with specific embodiments; it should be understood that these embodiments are used to illustrate the basic principles, main features and advantages of the present invention, and the present invention is not limited to the scope of the following embodiments; the implementation conditions adopted in the embodiments can be further adjusted according to specific requirements, and the implementation conditions not specified are usually the conditions in conventional experiments.

[0034] Unless otherwise specified in the following examples, all raw materials are commercially available or prepared by conventional methods in the art. Example 1

[0035] This embodiment provides a preparation process of wine-processed propolis Chinese medicinal slices, comprising the following steps: (1) dissolving and extracting the raw propolis with twice the volume of 95% ethanol aqueous solution at a temperature of 50° C. for 36 h to obtain propolis liquid; (2) Filter the propolis liquid through a plate and frame filter (type 100 plate and frame filter), recover the ethanol, collect the propolis extract (relative density of 1.2), and dry it in a vacuum at 55°C; (3) The propolis extract is dripped into pills (0.1 g / pill) using a pill machine to obtain wine-made propolis Chinese herbal medicine slices. The process parameters of the pill machine include: dripping temperature of 125°C, nozzle temperature of 60°C, coolant temperature of 3°C, dripping distance (the distance from the dripper to the coolant liquid surface) of 4.5 cm, coolant viscosity of 500 cst, dripping speed of 30 drops / min, and the amount of coolant used is 20 times that of the propolis extract. Example 2

[0036] On the basis of Example 1, this example provides a preparation process of wine-processed propolis Chinese medicinal slices, comprising the following steps: (1) dissolving and extracting the raw propolis with twice the volume of 95% ethanol aqueous solution at a temperature of 50° C. for 36 h to obtain propolis liquid; (2) filtering the propolis liquid through a plate and frame filter, recovering ethanol, collecting the propolis extract (relative density of 1.2), and drying it in a vacuum at 55°C; (3) The propolis extract was dripped into pills (0.1 g / pill) using a pill machine. The obtained propolis product was washed twice with dimethyl silicone oil at a temperature of 7°C and a viscosity of 50 cst, and then filtered to obtain wine-made propolis Chinese herbal medicine slices. The process parameters of the pill machine included: dripping temperature of 125°C, nozzle temperature of 60°C, coolant temperature of 3°C, dripping distance of 4.5 cm, coolant viscosity of 500 cst, dripping speed of 30 drops / min, and the amount of coolant used was 20 times that of the propolis extract. Example 3

[0037] For the wine-made propolis Chinese medicinal slices prepared in Example 2, this embodiment uses grapefruit peel material to remove the coolant dimethyl silicone oil remaining in the slices, and the preparation method of the grapefruit peel material includes the following steps: S1. Wash, dry and sterilize the grapefruit peel, and then crush it into 60 mesh grapefruit peel particles for later use; S2, dissolving corn gluten in 10 times the amount of ethanol aqueous solution (volume concentration of 90%), then adding grapefruit peel particles, stirring evenly and soaking for 10 minutes, then evaporating the solvent (ethanol and water) to obtain treated grapefruit peel particles, wherein the mass ratio of corn gluten to grapefruit peel particles is 0.05:1; S3. After boiling a 15 g / L tamarind gum aqueous solution for 25 min, add the treated grapefruit peel particles, mix evenly, and then press into a sheet at 0.1 MPa, and then dry at 85°C for 2 h to obtain a grapefruit peel material, wherein the mass ratio of tamarind gum to the treated grapefruit peel particles is 0.08:1.

[0038] The method of using grapefruit peel material to remove the coolant residual in the medicinal slices includes: cutting the grapefruit peel material, laying it in a high-efficiency coating pot, and then directly introducing the propolis Chinese medicinal slices obtained from the pill machine into the high-efficiency coating pot, and rotating it at 12r / min for 15min. Example 4

[0039] This embodiment provides a preparation process of wine-processed propolis Chinese medicinal slices, comprising the following steps: (1) dissolving and extracting the raw propolis with 3 times the volume of 95% ethanol aqueous solution at a temperature of 40° C. for 48 h to obtain propolis liquid; (2) filtering the propolis liquid through a plate and frame filter, recovering ethanol, collecting the propolis extract (relative density of 1.1), and drying it in a vacuum at 50°C; (3) The propolis extract was dripped into pills (0.2 g / pill) using a pill machine. The obtained propolis product was washed once with dimethyl silicone oil at a temperature of 5°C and a viscosity of 20 cst, and then filtered to obtain wine-made propolis Chinese herbal medicine slices. The process parameters of the pill machine included: dripping temperature of 115°C, nozzle temperature of 50°C, coolant temperature of 0°C, dripping distance of 4 cm, coolant viscosity of 350 cst, dripping speed of 35 drops / min, and the amount of coolant used was 25 times that of the propolis extract.

[0040] For the above-prepared wine-made propolis Chinese medicinal slices, this embodiment uses grapefruit peel material to remove the coolant dimethyl silicone oil remaining in the slices. The preparation method of the grapefruit peel material includes the following steps: S1. Wash, dry and sterilize the grapefruit peel, and then crush it into 30 mesh grapefruit peel particles for later use; S2, dissolving corn gluten in 5 times the amount of ethanol aqueous solution (volume concentration of 85%), then adding grapefruit peel particles, stirring evenly and soaking for 5 minutes, then evaporating the solvent (ethanol and water) to obtain treated grapefruit peel particles, wherein the mass ratio of corn gluten to grapefruit peel particles is 0.02:1; S3. After boiling a 10 g / L tamarind gum aqueous solution for 20 min, add the treated grapefruit peel particles, mix evenly, and then press into a sheet at 0.05 MPa, and then dry at 80°C for 3 h to obtain a grapefruit peel material, wherein the mass ratio of tamarind gum to the treated grapefruit peel particles is 0.05:1.

[0041] The method of using grapefruit peel material to remove the coolant remaining in the medicinal slices includes: cutting the grapefruit peel material, laying it in a high-efficiency coating pot, and then directly introducing the propolis Chinese medicinal slices obtained from the pill machine into the high-efficiency coating pot, and rotating it at 5r / min for 20 minutes. Example 5

[0042] This embodiment provides a preparation process of wine-processed propolis Chinese medicinal slices, comprising the following steps: (1) dissolving and extracting the raw propolis with 6 times the volume of 95% ethanol aqueous solution at 60°C for 24 hours to obtain propolis liquid; (2) filtering the propolis liquid through a plate and frame filter, recovering ethanol, collecting the propolis extract (relative density of 1.3), and drying it in a vacuum at 60°C; (3) The propolis extract was dripped into pills (0.1 g / pill) using a pill machine. The obtained propolis product was washed three times with dimethyl silicone oil at a temperature of 10°C and a viscosity of 100 cst, and then filtered to obtain wine-made propolis Chinese herbal medicine slices. The process parameters of the pill machine included: dripping temperature of 130°C, nozzle temperature of 70°C, coolant temperature of 6°C, dripping distance of 5 cm, coolant viscosity of 750 cst, dripping speed of 25 drops / min, and the amount of coolant used was 30 times that of the propolis extract.

[0043] For the above-prepared wine-made propolis Chinese medicinal slices, this embodiment uses grapefruit peel material to remove the coolant dimethyl silicone oil remaining in the slices. The preparation method of the grapefruit peel material includes the following steps: S1. Wash, dry and sterilize the grapefruit peel, and then crush it into 100-mesh grapefruit peel particles for later use; S2, dissolving corn gluten in 20 times the amount of ethanol aqueous solution (volume concentration of 90%), then adding grapefruit peel particles, stirring evenly and soaking for 20 minutes, then evaporating the solvent (ethanol and water) to obtain treated grapefruit peel particles, wherein the mass ratio of corn gluten to grapefruit peel particles is 0.08:1; S3. After boiling a tamarind gum aqueous solution with a mass concentration of 20 g / L for 30 minutes, the treated grapefruit peel particles are added and mixed evenly, and then pressed into a sheet at 0.2 MPa, and then dried at 90°C for 1 hour to obtain a grapefruit peel material, wherein the mass ratio of tamarind gum to the treated grapefruit peel particles is 0.1:1.

[0044] The method of using grapefruit peel material to remove the coolant remaining in the medicinal slices includes: cutting the grapefruit peel material, laying it in a high-efficiency coating pot, and then directly introducing the propolis Chinese medicinal slices obtained from the pill machine into the high-efficiency coating pot, and rotating it at 20r / min for 10 minutes.

[0045] Comparative Example 1 The difference between this comparative example and Example 1 is that in the preparation process step (2) of the wine-made propolis Chinese medicinal slices, the relative density of the propolis extract is 1.0.

[0046] Comparative Example 2 The difference between this comparative example and Example 1 is that in the preparation process step (2) of the wine-made propolis Chinese medicinal slices, the relative density of the propolis extract is 1.4.

[0047] Comparative Example 3 The difference between this comparative example and Example 1 is that in the preparation process step (3) of the wine-made propolis Chinese medicinal slices, the dripping temperature is 110°C.

[0048] Comparative Example 4 The difference between this comparative example and Example 1 is that in the preparation process step (3) of the wine-made propolis Chinese medicinal slices, the dripping temperature is 135°C.

[0049] Comparative Example 5 The difference between this comparative example and Example 1 is that in the step (3) of the preparation process of wine-made propolis Chinese medicinal slices, the temperature of the coolant is 8°C.

[0050] Comparative Example 6 The difference between this comparative example and Example 1 is that in the step (3) of the preparation process of wine-made propolis Chinese medicinal slices, the temperature of the coolant is -2°C.

[0051] Comparative Example 7 The difference between this comparative example and Example 1 is that in step (3) of the preparation process of wine-made propolis Chinese medicinal slices, the dripping distance is 2 cm.

[0052] Comparative Example 8 The difference between this comparative example and Example 1 is that in step (3) of the preparation process of wine-made propolis Chinese medicinal slices, the dripping distance is 7 cm.

[0053] Comparative Example 9 The difference between this comparative example and Example 1 is that in the preparation process step (3) of the wine-made propolis Chinese medicinal slices, the viscosity of the coolant is 200 cst.

[0054] Comparative Example 10 The difference between this comparative example and Example 1 is that in the preparation process step (3) of the wine-made propolis Chinese medicinal slices, the viscosity of the coolant is 1000 cst.

[0055] Comparative Example 11 The difference between this comparative example and Example 2 is that in step (3) of the preparation process of wine-made propolis Chinese medicinal slices, the viscosity of the dimethyl silicone oil used for cleaning is 200 cst.

[0056] Comparative Example 12 The difference between this comparative example and Example 2 is that in step (3) of the preparation process of the wine-made propolis Chinese medicinal slices, the temperature when the dimethyl silicone oil is used for cleaning is 3°C.

[0057] Comparative Example 13 The difference between this comparative example and Example 2 is that in step (3) of the preparation process of the wine-made propolis Chinese medicinal slices, the temperature when the dimethyl silicone oil is used for cleaning is 12°C.

[0058] Comparative Example 14 The difference between this comparative example and Example 3 is that conventional centrifugal drying operation is used to remove the coolant remaining in the slices, the centrifugal speed is 500r / min, and the centrifugation is performed for 10min.

[0059] Comparative Example 15 The difference between this comparative example and Example 3 is that the grapefruit peel is washed, dried, and sterilized and then directly used to remove the coolant remaining in the slices, and the coolant removal method is the same as that in Example 7.

[0060] Comparative Example 16 The difference between this comparative example and Example 3 is that no corn protein is added during the preparation of the pomelo peel material, and the preparation method of the pomelo peel material only includes step S1 and step S3.

[0061] Comparative Example 17 The difference between this comparative example and Example 3 is that in the grapefruit peel material preparation step S2, zein is replaced with gelatin.

[0062] Comparative Example 18 The difference between this comparative example and Example 3 is that in the grapefruit peel material preparation step S2, the mass ratio of zein to grapefruit peel particles is 0.01:1.

[0063] Comparative Example 19 The difference between this comparative example and Example 3 is that in the grapefruit peel material preparation step S2, the mass ratio of zein to grapefruit peel particles is 0.1:1.

[0064] Comparative Example 20 The difference between this comparative example and Example 3 is that in the grapefruit peel material preparation step S3, tamarind gum is replaced with gelatin.

[0065] Comparative Example 21 The difference between this comparative example and Example 3 is that in the grapefruit peel material preparation step S3, tamarind gum is replaced with starch.

[0066] Comparative Example 22 The difference between this comparative example and Example 3 is that in the grapefruit peel material preparation step S3, the mass ratio of tamarind gum to the treated grapefruit peel particles is 0.03:1.

[0067] Comparative Example 23 The difference between this comparative example and Example 3 is that in the grapefruit peel material preparation step S3, the mass ratio of tamarind gum to the treated grapefruit peel particles is 0.12:1.

[0068] 1. Basic tests of the wine-made propolis Chinese medicinal slices prepared by the present invention 1. Quality inspection The basic quality test of the wine-made propolis Chinese medicinal slices prepared in Examples 1-5 of the present invention was carried out with reference to the provisions of the Pharmacopoeia. The results are shown in Table 1.

[0069] Table 1

[0070] As can be seen from Table 1, all quality inspection items of the wine-processed propolis Chinese medicinal slices prepared in Examples 1-5 of the present invention meet the requirements of the Pharmacopoeia, indicating that the preparation process of the present invention can obtain wine-processed propolis Chinese medicinal slices with good overall quality.

[0071] 2. Appearance of the medicinal pieces The appearance of the wine-made propolis Chinese medicinal slices prepared in Examples 1-5 of the present invention and Comparative Examples 1-10 was scored, and the scoring standards for each index were: 1 point (poor), 2 points (good), and 3 points (excellent). The results are shown in Table 2.

[0072] Table 2

[0073] As shown in Table 2, the appearance scores of the wine-made propolis Chinese medicinal slices prepared in Examples 1-5 of the present invention are all high, and all indicators are excellent. Comparative Examples 1-10 respectively change the relative density of the propolis extract, dripping temperature, coolant temperature, dripping distance, coolant viscosity and other process parameters, and the appearance scores of the slices are all reduced.

[0074] 2. Dimethyl silicone oil residue in the wine-made propolis Chinese medicinal slices prepared by the present invention 1. The content of dimethyl silicone oil with strong binding properties in the decoction pieces The content of dimethyl silicone oil with strong binding property in the wine-made propolis Chinese medicinal slices prepared in Example 1 of the present invention and Comparative Examples 1-10 was measured, and the results are shown in Table 3.

[0075] The content of dimethicone with strong binding properties in medicinal pieces = total dimethicone residue - free dimethicone content on the surface of medicinal pieces.

[0076] Among them, the method for determining the total dimethyl silicone oil residue refers to the infrared spectroscopy method (Pharmacopoeia Part IV - Pharmaceutical Excipients - Dimethyl silicone oil - Content Determination), and the method for determining the free dimethyl silicone oil content on the surface of medicinal pieces is to measure the weight loss after centrifugal drying.

[0077] Table 3

[0078] It can be seen from Table 3 that, compared with Comparative Examples 1-10, the content of dimethyl silicone oil with strong binding in the wine-made propolis Chinese medicinal slices prepared in Example 1 of the present invention is as low as 0.001%, indicating that the preparation process of the medicinal slices of the present invention can reduce the content of dimethyl silicone oil with strong binding in the medicinal slices.

[0079] 2. Content of free dimethyl silicone oil on the surface of medicinal pieces The content of free dimethyl silicone oil on the surface of the wine-made propolis Chinese medicinal slices prepared in Examples 1 and 2 of the present invention and Comparative Examples 11-13 was measured. The results are shown in Table 4.

[0080] Table 4

[0081] It can be seen from Table 4 that, compared with Example 1, after Example 2 of the present invention uses low-viscosity dimethyl silicone oil to clean the medicinal pieces, compared with the higher viscosity dimethyl silicone oil used as a coolant, the low-viscosity dimethyl silicone oil is more difficult to adhere to the surface of the medicinal pieces, and has a lower relative density, thereby effectively reducing the content of free dimethyl silicone oil on the surface of the medicinal pieces.

[0082] 3. Effect of the grapefruit peel material of the present invention in removing dimethyl silicone oil 1. Residual dimethyl silicone oil removal rate The residual dimethyl silicone oil in the slices was removed according to the methods of Examples 3-5 of the present invention and Comparative Examples 14-23, and the removal rates of the residual dimethyl silicone oil in the wine-processed propolis slices were respectively measured. The results are shown in Table 5.

[0083] Residual dimethyl silicone oil removal rate = 100% × (total dimethyl silicone oil residue in the medicinal slices before removing dimethyl silicone oil - total dimethyl silicone oil residue in the medicinal slices after removing dimethyl silicone oil) / total dimethyl silicone oil residue in the medicinal slices before removing dimethyl silicone oil.

[0084] Among them, the method for determining the total dimethicone residue refers to infrared spectroscopy (Pharmacopoeia Part IV - Pharmaceutical Excipients - Dimethicone - Content Determination).

[0085] 2. Adhesion of slices after removing dimethyl silicone oil After removing the residual dimethyl silicone oil in the slices according to the methods of Examples 3-5 of the present invention and Comparative Examples 14-23, the adhesion between the slices was observed respectively. The results are shown in Table 5.

[0086] Table 5

[0087] As can be seen from Table 5, the methods of Examples 3-5 of the present invention are used to remove residual dimethyl silicone oil in the medicinal pieces, with a removal rate as high as 91.0-91.5%, and there is no adhesion between the medicinal pieces.

[0088] Comparative Example 14 uses conventional centrifugal drying to remove dimethyl silicone oil. Although its dimethyl silicone oil removal rate is not much different from that of Examples 3-5, severe adhesion occurs between the pieces. Comparative Example 15 directly uses grapefruit peel to remove dimethyl silicone oil. Its removal rate is significantly reduced, and moderate adhesion occurs between the pieces. Comparative Examples 16-23 respectively change the preparation method of grapefruit peel material. As a result, the dimethyl silicone oil removal rate decreases to varying degrees, and adhesion occurs to varying degrees between the pieces.

[0089] 3. Appearance and quality loss of medicinal pieces after removal of dimethyl silicone oil The residual dimethicone in the slices was removed according to the methods of Examples 3-5 of the present invention and Comparative Examples 14-23. The appearance of the slices before and after the removal of dimethicone (including smoothness and roundness, refer to the first item) was scored, and the quality loss of the slices was evaluated by observing the propolis adhered to the surface of the removal material or equipment. The results are shown in Table 6.

[0090] Table 6

[0091] As shown in Table 6, the residual dimethyl silicone oil in the medicinal slices was removed by the method of Examples 3-5 of the present invention, and the appearance of the medicinal slices was basically unchanged, and there was no obvious quality loss.

[0092] Comparative Examples 14 and 15 respectively changed the method of removing dimethicone, and Comparative Examples 16-23 respectively changed the preparation method of grapefruit peel material. As a result, the appearance of the medicinal pieces deteriorated and quality loss occurred to varying degrees.

[0093] 4. Softness and elasticity of the grapefruit peel material of the present invention The softness (ie, hardness) and elasticity of the grapefruit peel materials obtained in Examples 3-5 and Comparative Examples 15-23 were measured using a texture analyzer. The results are shown in Table 7 below.

[0094] Table 7

[0095] As shown in Table 7, the hardness of the grapefruit peel material prepared in Examples 3-5 of the present invention is 48-51 N / g, and the elasticity index is in the range of 0.62-0.66. Combined with the results of Tables 5 and 6, it can be seen that when the hardness and elasticity of the grapefruit peel material are within this range, the effect of removing dimethyl silicone oil is better, and it will not affect the appearance of the decoction piece. Therefore, the present invention can improve the effect of removing dimethyl silicone oil by obtaining grapefruit peel materials with appropriate hardness and elasticity. Comparative Example 15 directly uses grapefruit peel raw materials, and Comparative Examples 16-23 respectively change the preparation method of grapefruit peel materials, so that the hardness and elasticity of the grapefruit peel material exceed the appropriate range, and the effect of removing dimethyl silicone oil also deteriorates.

[0096] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A preparation process for wine-processed propolis Chinese medicinal slices, characterized in that: The following steps are involved: (1) dissolving and extracting raw propolis with ethanol aqueous solution to obtain propolis liquid; (2) filtering the propolis liquid through a plate and frame, recovering ethanol, and collecting the propolis extract; (3) The propolis extract is dripped into a pill machine to obtain wine-made propolis Chinese herbal medicine slices. The process parameters of the pill machine include: dripping temperature of 115-130°C, nozzle temperature of 50-70°C, coolant temperature of 0-6°C, dripping distance of 4-5cm, and the coolant used is dimethyl silicone oil with a viscosity of 350-750cst.

2. The preparation process according to claim 1, characterized in that: In step (1), the extraction temperature is 40-60°C and the extraction time is 24-48h.

3. The preparation process according to claim 1, characterized in that: In step (2), the relative density of the propolis extract is 1.1-1.

3.

4. The preparation process according to claim 1, characterized in that: In step (3), the dripping speed is 25-35 drops / min, and the amount of coolant used is 15-50 times that of propolis extract.

5. The preparation process according to claim 1, characterized in that: Step (3) comprises: dripping the propolis extract into a pill-dropping machine, washing the obtained propolis product with dimethyl silicone oil having a temperature of 5-10° C. and a viscosity of 20-100 cst, and then filtering to obtain wine-made propolis Chinese medicinal slices. The process parameters of the pill-dropping machine include: dripping temperature of 115-130° C., nozzle temperature of 50-70° C., coolant temperature of 0-6° C., dripping distance of 4-5 cm, and the coolant used is dimethyl silicone oil with a viscosity of 350-750 cst.

6. A grapefruit peel material used in the preparation process of the wine-made propolis Chinese medicinal slices according to claim 1, characterized in that: For the prepared wine-made propolis Chinese medicinal slices, a grapefruit peel material is used to remove the coolant remaining in the slices. The preparation method of the grapefruit peel material comprises the following steps: S1. Wash, dry and sterilize the grapefruit peel, and then crush it into grapefruit peel particles for later use; S2, dissolving corn protein in an ethanol aqueous solution, then adding grapefruit peel particles, stirring evenly and soaking for 3-20 minutes, and then evaporating the solvent to obtain treated grapefruit peel particles; S3. After boiling the tamarind gum solution for 20-30 minutes, add the treated grapefruit peel particles, mix evenly, and then press into shape, and then dry at 80-90° C. for 1-4 hours to obtain the grapefruit peel material.

7. The grapefruit peel material according to claim 6, characterized in that: In step S1, the particle size of the grapefruit peel particles is 30-100 meshes.

8. The grapefruit peel material according to claim 6, characterized in that: In step S2, the mass ratio of corn gluten to grapefruit peel particles is (0.02-0.08):1, the volume concentration of the ethanol aqueous solution is 85-90%, and the amount used is 5-50 times that of corn gluten.

9. The grapefruit peel material according to claim 6, characterized in that: In step S3, the mass ratio of tamarind gum to the treated grapefruit peel particles is (0.05-0.1):1, and the mass concentration of the tamarind gum aqueous solution is 10-20 g / L.

10. The grapefruit peel material according to claim 6, characterized in that: The method of using grapefruit peel material to remove the coolant remaining in the medicinal slices includes: cutting the grapefruit peel material, laying it in a rotatable container, and then directly introducing the propolis Chinese medicinal slices obtained from the pill dropping machine into the rotatable container, and rotating it at 5-20r / min for 10-20min.

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