Anti-radiation composition and preparation method thereof

Abstract

The invention relates to an anti-radiation composition and a preparation method thereof, and belongs to the technical field of anti-radiation drugs. The anti-radiation composition is prepared from the following components in parts by mass: 0.2 to 8 parts of herba houttuyniae extracellular vesicles, 10 to 22 parts of radix ginseng, 5 to 20 parts of radix astragali seu hedysari, 5 to 15 parts of lucid ganoderma, 6 to 35 parts of fructus gardeniae and 10 to 30 parts of emilia sonchifolia; the houttuynia cordata extracellular vesicles have a good anti-radiation effect, and the houttuynia cordata extracellular vesicles are matched with ginseng, lucid ganoderma, astragalus membranaceus, gardenia and emilia sonchifolia for use, so that skin injury, lipid peroxidation and hematopoiesis and blood system function injury caused by radiation can be relieved on the premise that the body safety is not damaged, and the function of preventing and treating radiation is achieved.

Description

Technical Field

[0001] The present application relates to the technical field of anti-radiation drugs, and in particular to an anti-radiation composition and a preparation method thereof. Background Art

[0002] With the development of modern technology, people use mobile phones, tablets, computers and other products for a long time every day. Electromagnetic radiation is difficult to avoid for daily workers. In the long run, visual fatigue accompanied by dizziness, palpitations, and memory loss are likely to occur. In addition, ionizing radiation generated by X-ray detection, radiotherapy and other treatment methods in hospitals can damage human DNA and hematopoietic function. Therefore, it is particularly important to develop a safe and effective anti-radiation product.

[0003] Someone has proposed an easy-to-wear radiation-proof medical isolation suit that can physically block the harm caused by some instrument radiation. However, this isolation suit is expensive and inconvenient to wear. Summary of the invention

[0004] The present application provides an anti-radiation composition and a preparation method thereof, so as to reduce the influence of radiation in daily life on physical health.

[0005] In a first aspect, the present application provides an anti-radiation composition, the ingredients of which, by weight, include: 0.2 to 8 parts of extracellular vesicles of Houttuynia cordata, 10 to 22 parts of ginseng, 5 to 20 parts of astragalus, 5 to 15 parts of ganoderma lucidum, 6 to 35 parts of gardenia, and 10 to 30 parts of radix erythematosus.

[0006] As an optional embodiment, the ingredients of the anti-radiation composition include, by mass, 2-6 parts of Houttuynia cordata extracellular vesicles, 14-18 parts of ginseng, 10-15 parts of astragalus, 7-13 parts of ganoderma lucidum, 10-30 parts of gardenia and 15-25 parts of radix erythrorhizon.

[0007] As an optional embodiment, the Houttuynia cordata extracellular vesicles are nanoparticles with a size of 50 nm to 220 nm.

[0008] As an optional embodiment, the Houttuynia cordata extracellular vesicles have at least one of a tray-shaped structure or a hemispherical structure.

[0009] As an optional embodiment, the anti-radiation composition is in the form of at least one of a decoction, a powder or a dressing.

[0010] In a second aspect, the present application provides a method for preparing an anti-radiation composition, the method comprising:

[0011] Obtaining Houttuynia cordata raw material;

[0012] The Houttuynia cordata raw material is crushed to obtain a first Houttuynia cordata juice;

[0013] Performing a first centrifugation and filtration on the Houttuynia cordata juice to remove impurities, thereby obtaining a second Houttuynia cordata juice;

[0014] The second Houttuynia cordata juice is subjected to a second centrifugation, and a PBS solution is added to resuspend the precipitate to obtain Houttuynia cordata extracellular vesicles;

[0015] The Houttuynia cordata extracellular vesicles are combined with ginseng, astragalus, ganoderma lucidum, gardenia and radix eryngii to obtain an anti-radiation composition, wherein the components of the anti-radiation composition include, by mass, 0.2-8 parts of Houttuynia cordata extracellular vesicles, 10-22 parts of ginseng, 5-20 parts of astragalus, 5-15 parts of ganoderma lucidum, 6-35 parts of gardenia and 10-30 parts of radix eryngii.

[0016] As an optional embodiment, the Houttuynia cordata raw material includes at least one of the rhizome or tender shoots of the Houttuynia cordata plant.

[0017] As an optional embodiment, the centrifugal force of the first centrifugation is 10000g to 150000g; and / or

[0018] The first centrifugation time is 1 h to 3 h; and / or

[0019] The filtration comprises two filtrations, and the two filtrations comprise gauze filtration and microporous membrane filtration.

[0020] As an optional embodiment, the centrifugal force of the second centrifugation is ≥ 100000 g; and / or

[0021] The second centrifugation time is 2 h to 6 h.

[0022] As an optional embodiment, the PBS solution comprises, by mole fraction, 5 to 10 parts of Na2HPO4, 130 to 140 parts of NaCl and 1 to 5 parts of NaH2PO4; and / or

[0023] The pH value of the PBS solution is 7.2-7.6.

[0024] The above technical solution provided by the embodiment of the present application has the following advantages compared with the prior art:

[0025] The anti-radiation composition provided in the embodiment of the present application uses the extracellular vesicles of Houttuynia cordata in combination with ginseng, ganoderma lucidum, astragalus, gardenia, and red licorice. The extracellular vesicles of Houttuynia cordata have a good anti-radiation effect. Ginseng has the effects of replenishing qi, calming the mind and improving eyesight. The ginsenosides and polysaccharides contained in it can remove free radicals caused by radiation and reduce lipid peroxidation. Ganoderma lucidum belongs to the heart, lung, liver and kidney meridians, and has the effects of replenishing qi, calming the mind and improving the body's immunity. In addition, Ganoderma lucidum can protect the body from functional damage caused by radiation by reducing oxidative damage and protecting DNA from breakage. Astragalus has the effects of replenishing qi and nourishing blood, astringing sores, promoting wound healing, and can also protect the hematopoietic system and enhance the body's immune system function. Gardenia can clear away heat and cool blood, resist inflammation and analgesia, and resist oxidation, and reduce cell damage caused by radiation. Red licorice has the medicinal effects of clearing away heat and detoxifying, antibacterial and anti-inflammatory, and is also rich in nutrients such as crude protein, crude fiber, vitamin C, etc. It can be used as both medicine and food, and can be applied externally or taken internally. When the above-mentioned Chinese medicines are used together, they can reduce the skin damage, lipid peroxidation, and hematopoietic and blood system function damage caused by radiation without damaging the safety of the body, thereby playing a role in preventing and treating radiation. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the present application and, together with the description, serve to explain the principles of the present application.

[0027] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, for ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0028] Figure 1 A schematic diagram of a process for a method provided in an embodiment of the present application;

[0029] Figure 2 This is a characterization diagram of the morphology of the extracellular vesicles of Houttuynia cordata provided in the examples of the present application;

[0030] Figure 3 This is a diagram of the particle size of the extracellular vesicles of Houttuynia cordata provided in the examples of the present application. DETAILED DESCRIPTION

[0031] In order to make the purpose, technical solution and advantages of the embodiments of the present application clearer, the technical solution in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of this application.

[0032] Unless otherwise specified, various raw materials, reagents, instruments and equipment used in this application can be purchased from the market or prepared by existing methods.

[0033] An embodiment of the present application provides an anti-radiation composition, the components of which, by weight, include: 0.2 to 8 parts of extracellular vesicles of Houttuynia cordata, 10 to 22 parts of ginseng, 5 to 20 parts of astragalus, 5 to 15 parts of ganoderma lucidum, 6 to 35 parts of gardenia, and 10 to 30 parts of radix et rhizoma.

[0034] In some embodiments, the ingredients of the anti-radiation composition include, by weight: 2-6 parts of Houttuynia cordata extracellular vesicles, 14-18 parts of ginseng, 10-15 parts of astragalus, 7-13 parts of ganoderma lucidum, 10-30 parts of gardenia and 15-25 parts of radix erythrorhizon.

[0035] The radiation-resistant composition uses Houttuynia cordata extracellular vesicles in combination with ginseng, ganoderma lucidum, astragalus, gardenia and red licorice. The Houttuynia cordata extracellular vesicles have a good radiation-resistant effect. Ginseng has the effects of replenishing qi, calming the mind and improving eyesight. The ginsenosides and polysaccharides contained in the ginsenosides can remove free radicals caused by radiation and reduce lipid peroxidation. Ganoderma lucidum belongs to the heart, lung, liver and kidney meridians and has the effects of replenishing qi, calming the mind and improving the body's immunity. In addition, Ganoderma lucidum can protect the body from functional damage caused by radiation by reducing oxidative damage and protecting DNA from breaking. Astragalus has the effects of replenishing qi and nourishing blood, astringing sores, promoting tissue regeneration and promoting wound healing, and can also protect the hematopoietic system and enhance the body's immune system function. Gardenia can clear away heat and cool blood, resist inflammation and relieve pain, resist oxidation, and reduce cell damage caused by radiation. Red licorice has the medicinal effects of clearing away heat and detoxifying, and resisting bacteria and inflammation, and is rich in nutrients such as crude protein, crude fiber, vitamin C, etc. It can be used as both medicine and food, and can be applied externally or taken internally. When the above-mentioned Chinese medicines are used together, they can reduce the skin damage, lipid peroxidation, and hematopoietic and blood system function damage caused by radiation without damaging the safety of the body, thereby playing a role in preventing and treating radiation.

[0036] Among them, anti-radiation includes preventing and treating damage to body functions caused by ionizing radiation and ultraviolet radiation.

[0037] In some embodiments, the extracellular vesicles of Houttuynia cordata are nanoparticles of 50 nm to 220 nm. The extracellular vesicles of Houttuynia cordata have at least one of a saucer-shaped structure and a hemispherical structure.

[0038] In some embodiments, the product types of the anti-radiation composition include decoctions, powders, dressings, and the like.

[0039] Those skilled in the art will appreciate that the radiation-resistant composition containing extracellular vesicles of Houttuynia cordata can be used in food, medicine, health products and cosmetics.

[0040] Figure 1 A flow chart of the method provided in the embodiment of the present application is as follows: Figure 1 As shown, based on a general inventive concept, the embodiments of the present application also provide a method for preparing an anti-radiation composition.

[0041] This method is used to prepare the above-mentioned anti-radiation composition. The specific content of the anti-radiation composition can be referred to the above-mentioned embodiment. Since this method adopts part or all of the technical solutions of the above-mentioned embodiment, it at least has all the beneficial effects brought by the technical solutions of the above-mentioned embodiment, which will not be repeated here one by one.

[0042] In some embodiments, the method comprises:

[0043] S1. Obtaining Houttuynia cordata raw material;

[0044] In some embodiments, the Houttuynia cordata raw material includes at least one of the rhizome or tender shoots of the Houttuynia cordata plant.

[0045] S2. crushing the Houttuynia cordata raw material to obtain a first Houttuynia cordata juice;

[0046] In some embodiments, the Houttuynia cordata raw material is washed and cut into small pieces; then the Houttuynia cordata raw material is crushed to extract the juice, thereby obtaining the first Houttuynia cordata juice.

[0047] S3. The Houttuynia cordata juice is first centrifuged and filtered to remove impurities to obtain a second Houttuynia cordata juice;

[0048] In some embodiments, the centrifugal force of the first centrifugation is 10000 g to 150000 g; the time of the first centrifugation is 1 h to 3 h.

[0049] In some embodiments, the filtration comprises two filtrations, wherein the two filtrations comprise gauze filtration and microporous membrane filtration.

[0050] S4. performing a second centrifugation on the second Houttuynia cordata juice, and adding PBS solution to resuspend the precipitate to obtain Houttuynia cordata extracellular vesicles;

[0051] In some embodiments, the centrifugal force of the second centrifugation is ≥ 100,000 g; and the time of the second centrifugation is 2 h to 6 h.

[0052] In some embodiments, the PBS solution comprises 5-10 parts of Na2HPO4, 130-140 parts of NaCl and 1-5 parts of NaH2PO4 by mole fraction; the pH value of the PBS solution is 7.2-7.6. Exemplarily, the PBS solution contains 5-10 mM Na2HPO4, 130-140 mM NaCl, 1-5 mM NaH2PO4, and the pH value of the PBS solution is 7.4.

[0053] S5. The extracellular vesicles of Houttuynia cordata are combined with ginseng, astragalus, ganoderma lucidum, gardenia and radix eryngii to obtain an anti-radiation composition, wherein the components of the anti-radiation composition include, by mass, 0.2 to 8 parts of extracellular vesicles of Houttuynia cordata, 10 to 22 parts of ginseng, 5 to 20 parts of astragalus, 5 to 15 parts of ganoderma lucidum, 6 to 35 parts of gardenia and 10 to 30 parts of radix eryngii.

[0054] The method uses differential ultracentrifugation to separate extracellular vesicles from Houttuynia cordata, which is rich in volatile oils, flavonoids, alkaloids and other substances. Compared with Houttuynia cordata with antibacterial, anti-inflammatory and anti-radiation effects, the isolated Houttuynia cordata extracellular vesicles are enriched with a large amount of miRNA / mRNA, which makes the anti-radiation effect better. Then, the extracellular vesicles are combined with ginseng, ganoderma lucidum, astragalus, gardenia and radix eryngii to form an anti-radiation composition. The obtained radiation-resistant composition is prepared by combining the extracellular vesicles of Houttuynia cordata with ginseng, ganoderma lucidum, astragalus, gardenia and red licorice. The extracellular vesicles of Houttuynia cordata have good radiation-resistant effects. Ginseng has the effects of replenishing qi, calming the nerves and improving eyesight. The ginsenosides and polysaccharides contained in the ginsenosides can remove free radicals caused by radiation and reduce lipid peroxidation. Ganoderma lucidum belongs to the heart, lung, liver and kidney meridians and has the effects of replenishing qi, calming the nerves and improving the body's immunity. In addition, Ganoderma lucidum can protect the body from functional damage caused by radiation by reducing oxidative damage and protecting DNA from breaking. Astragalus has the effects of replenishing qi and nourishing blood, astringing sores, promoting wound healing, and can also protect the hematopoietic system and enhance the body's immune system function. Gardenia can clear away heat and cool blood, resist inflammation and relieve pain, resist oxidation, and reduce cell damage caused by radiation. Red licorice has the medicinal effects of clearing away heat and detoxifying, and resisting bacteria and inflammation, and is rich in nutrients such as crude protein, crude fiber, vitamin C, etc. It can be used as both medicine and food, and can be applied externally or taken internally. When the above-mentioned Chinese medicines are used together, they can reduce the skin damage, lipid peroxidation, and hematopoietic and blood system function damage caused by radiation without damaging the safety of the body, thereby playing a role in preventing and treating radiation.

[0055] Compared with the prior art, this application has at least the following beneficial effects:

[0056] The present application provides a simple and repeatable method for preparing extracellular vesicles of Houttuynia cordata. The extracellular vesicles obtained by the preparation method have high purity and concentration.

[0057] The extracellular vesicles of Houttuynia cordata obtained by the preparation method provided in the present application show obvious anti-radiation effect and mitigate the damage caused by radiation.

[0058] More importantly, the anti-radiation composition based on extracellular vesicles of Houttuynia cordata provided in the present application shows significant anti-radiation effect and good safety, greatly reducing the damage caused by radiation.

[0059] The present application will be further described below in conjunction with specific embodiments. It should be understood that these embodiments are intended only to illustrate the present application and are not intended to limit the scope of the present application. The experimental methods for which specific conditions are not specified in the following examples are usually measured according to national standards. If there is no corresponding national standard, then the conditions recommended by the manufacturer are followed.

[0060] Preparation and characterization of extracellular vesicles from Houttuynia cordata

[0061] Take 100g of freshly picked Houttuynia cordata, wash off the mud and sand with ultrapure water, cut into small pieces, crush to extract the juice; add 100mL PBS buffer to mix, then centrifuge at 12000g for 2h, take the supernatant; pass through a 0.22 microporous filter membrane and centrifuge at 150000g for 2h, the precipitate is the extracellular vesicles.

[0062] The prepared extracellular vesicles were placed under a transmission electron microscope to observe their morphological structure. Figure 2 As shown in FIG. 1 , it was found that there were many tray-shaped double-layer membrane nanoparticles; and the nanoparticle tracking analyzer was used to detect, such as Figure 3 As shown, the particle concentration was found to be 2.4E+13 Particles / mL, and most of the particles were between 100-220 nm, with an average particle size of 172.5 nm.

[0063] Verification of the anti-radiation function of extracellular vesicles of Houttuynia cordata

[0064] The mice were randomly divided into three groups, 10 in each group, which were set as normal control group, radiation model group, and Houttuynia cordata extracellular vesicle group. The mice in the normal control group and radiation model group were gavaged with normal saline every day, and the mice in the Houttuynia cordata extracellular vesicle group were gavaged with Houttuynia cordata extracellular vesicle every day for 14 days. On the 15th day, the mice in the radiation model group and the Houttuynia cordata extracellular vesicle group were placed in γ-ray irradiation for 1 hour and then transferred to a normal growth environment. The death of mice in each group was recorded. The results are shown in Table 1.

[0065] Table 1 Survival rate of mice after treatment with extracellular vesicles of Houttuynia cordata

[0066]

[0067] The results are shown in the table above. Mice treated with extracellular vesicles of Houttuynia cordata can prolong the survival time of mice after radiation.

[0068] Anti-radiation composition based on extracellular vesicles of Houttuynia cordata

[0069] The mice were randomly divided into five groups, 10 in each group, and set as implementation group 1, implementation group 2, implementation group 3, implementation group 4 and implementation group 5. Implementation group 1, implementation group 2, implementation group 3, implementation group 4 and implementation group 5 were gavaged with the anti-radiation composition for 14 days. The components of the anti-radiation composition of each group are shown in Table 2 below by mass.

[0070] Table 2 Anti-radiation composition based on extracellular vesicles of Houttuynia cordata

[0071]

[0072] On the 15th day, the mice in implementation group 1, implementation group 2, implementation group 3, implementation group 4 and implementation group 5 were irradiated with gamma rays and then transferred to a normal growth environment. The death of mice in each group was recorded. The results are shown in Table 3.

[0073] Table 3 Survival rate of mice after treatment with the extracellular vesicle composition of Houttuynia cordata

[0074] Group 7d 14d 21d 28d 35d 42d Implementation Group 1 100％ 80％ 50％ 30％ 10％ 0％ Implementation Group 2 100％ 90％ 50％ 10％ 0％ 0％ Implementation Group 3 100％ 90％ 60％ 20％ 0％ 0％ Implementation Group 4 100％ 100％ 70％ 50％ 20％ 0％ Implementation Group 5 100％ 100％ 80％ 60％ 30％ 10％

[0075] It can be seen from the above table that intragastric administration of the extracellular vesicle composition of Houttuynia cordata can prolong the survival time of mice after radiation.

[0076] Anti-radiation composition based on Houttuynia cordata

[0077] The mice were randomly divided into five groups, 10 in each group, and set as control group 1, control group 2, control group 3, control group 4 and control group 5. Control group 1, control group 2, control group 3, control group 4 and control group 5 were gavaged with the anti-radiation composition for 14 days. The components of the anti-radiation composition of each group are shown in Table 4 below by mass.

[0078] Table 4 Anti-radiation composition based on Houttuynia cordata

[0079] Group Houttuynia cordata Ginseng Astragalus Ganoderma Gardenia A little red Comparison group 1 2 20 5 8 35 20 Comparison group 2 0.2 10 20 10 6 30 Comparison group 3 0.5 12 16 12 15 10 Comparison group 4 3 15 10 13 30 22 Comparison group 5 5 22 15 15 20 25

[0080] On the 15th day, the mice in control group 1, control group 2, control group 3, control group 4 and control group 5 were irradiated with γ rays and then transferred to a normal growth environment. The death of mice in each group was recorded. The results are shown in Table 5.

[0081] Table 5 Survival rate of mice after treatment with Houttuynia cordata combination

[0082] Group 7d 14d 21d 28d 35d 42d Comparison group 1 90％ 70％ 50％ 20％ 0％ 0％ Comparison group 2 80％ 50％ 30％ 10％ 0％ 0％ Comparison group 3 80％ 60％ 30％ 20％ 0％ 0％ Comparison group 4 90％ 80％ 60％ 30％ 20％ 0％ Comparison group 5 100％ 90％ 70％ 50％ 20％ 0％

[0083] The results are shown in the table above. Oral administration of the Houttuynia cordata combination can prolong the survival time of mice after radiation, but it is not as effective as the Houttuynia cordata extracellular vesicle combination.

[0084] In summary, the preparation method provided in the present application successfully isolates extracellular vesicles with clear edges, high purity and concentration from Houttuynia cordata. It was subsequently found that the isolated Houttuynia cordata extracellular vesicles can prolong the survival time of irradiated mice. After the prepared extracellular vesicles are combined with traditional Chinese medicines such as ginseng, astragalus, ganoderma lucidum, gardenia, and iris, the anti-radiation effect of the Houttuynia cordata extracellular vesicles can be greatly enhanced.

[0085] Various embodiments of the present application may be presented in the form of a range; it should be understood that the description in the form of a range is only for convenience and brevity, and should not be understood as a rigid limitation on the scope of the present application; therefore, the range description should be considered to have specifically disclosed all possible sub-ranges and single numerical values ​​within the range. For example, the range description from 1 to 6 should be considered to have specifically disclosed sub-ranges, such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., as well as single numbers within the range, such as 1, 2, 3, 4, 5 and 6, which apply regardless of the range. In addition, whenever a numerical range is indicated herein, it is meant to include any cited number (fractional or integer) within the indicated range.

[0086] In the present application, in the absence of any contrary description, the directional words used, such as "upper" and "lower", are specifically the directions of the drawings in the accompanying drawings. In addition, in the description of the present specification, the terms "including", "comprising", etc. refer to "including but not limited to". In this article, relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply that there is any such actual relationship or order between these entities or operations. In this article, "and / or" describes the association relationship of the associated objects, indicating that there may be three relationships, for example, A and / or B, which can represent: A exists alone, A and B exist at the same time, and B exists alone. Wherein A, B can be singular or plural. In this article, "at least one" refers to one or more, and "plural" refers to two or more. "At least one", "at least one of the following" or similar expressions refer to any combination of these items, including any combination of singular or plural items. For example, "at least one of a, b or c", or "at least one of a, b and c", can both mean: a, b, c, ab (i.e. a and b), ac, bc, or abc, where a, b and c can be single or multiple.

[0087] The above description is only a specific implementation of the present application, so that those skilled in the art can understand or implement the present application. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to the embodiments shown herein, but will conform to the widest range consistent with the principles and novel features applied for herein.

Claims

1. A radiation-resistant composition, characterized in that: The components of the radiation-resistant composition include, by weight: 0.2-8 parts of Houttuynia cordata extracellular vesicles, 10-22 parts of ginseng, 5-20 parts of astragalus, 5-15 parts of ganoderma lucidum, 6-35 parts of gardenia and 10-30 parts of radix eryngii.

2. The radiation-resistant composition according to claim 1, characterized in that: The components of the anti-radiation composition include, by weight, 2-6 parts of Houttuynia cordata extracellular vesicles, 14-18 parts of ginseng, 10-15 parts of astragalus, 7-13 parts of ganoderma lucidum, 10-30 parts of gardenia and 15-25 parts of radix eryngii.

3. The radiation-resistant composition according to any one of claims 1 to 2, characterized in that: The Houttuynia cordata extracellular vesicles are nanoparticles with a size of 50 nm to 220 nm.

4. The radiation-resistant composition according to any one of claims 1 to 2, characterized in that: The Houttuynia cordata extracellular vesicles have at least one of a tray-shaped structure and a hemispherical structure.

5. The radiation-resistant composition according to any one of claims 1 to 2, characterized in that: The anti-radiation composition is in the form of at least one of a decoction, a powder or a dressing.

6. A method for preparing an anti-radiation composition, characterized in that: The method comprises: Obtaining Houttuynia cordata raw material; The Houttuynia cordata raw material is crushed to obtain a first Houttuynia cordata juice; Performing a first centrifugation and filtration on the Houttuynia cordata juice to remove impurities, thereby obtaining a second Houttuynia cordata juice; The second Houttuynia cordata juice is subjected to a second centrifugation, and a PBS solution is added to resuspend the precipitate to obtain Houttuynia cordata extracellular vesicles; The Houttuynia cordata extracellular vesicles are combined with ginseng, astragalus, ganoderma lucidum, gardenia and radix eryngii to obtain an anti-radiation composition, wherein the components of the anti-radiation composition include, by mass, 0.2-8 parts of Houttuynia cordata extracellular vesicles, 10-22 parts of ginseng, 5-20 parts of astragalus, 5-15 parts of ganoderma lucidum, 6-35 parts of gardenia and 10-30 parts of radix eryngii.

7. The radiation-resistant composition according to claim 6, characterized in that: The Houttuynia cordata raw material includes at least one of the rhizome or tender shoots of the Houttuynia cordata plant.

8. The radiation-resistant composition according to claim 6, characterized in that: The centrifugal force of the first centrifugation is 10000g to 150000g; and / or The first centrifugation time is 1 h to 3 h; and / or The filtration comprises two filtrations, and the two filtrations comprise gauze filtration and microporous membrane filtration.

9. The radiation-resistant composition according to claim 6, characterized in that: The centrifugal force of the second centrifugation is ≥ 100000 g; and / or The second centrifugation time is 2 h to 6 h.

10. The radiation-resistant composition according to claim 6, characterized in that: The PBS solution comprises, by mole fraction, 5 to 10 parts of Na2HPO4, 130 to 140 parts of NaCl and 1 to 5 parts of NaH2PO4; and / or The pH value of the PBS solution is 7.2-7.6.

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