Compound preparation for inhibiting viruses and preparation method thereof

Abstract

The invention relates to a compound preparation for inhibiting viruses. The compound preparation is mainly prepared from, by weight, 5-10 g of indigo naturalis, 5-10 g of fortune eupatorium herb, 5-10 g of tatarian aster root, 5-10 g of cherokee rose fruit, 5-10 g of pyrrosia lingua, 5-10 g of lilac daphne flower bud, 5-10 g of astragalus membranaceus, 5-10 g of eucommia ulmoides, 10-15 g of glucose, 3-5 g of probiotics and 3-5 g of red yeast rice. According to the formula of the compound preparation, reasonable compatibility of traditional Chinese medicines is adopted, meanwhile, the rose distillate is utilized for fermentation, the effect of the medicine is enhanced, interference and replication of viruses can be well inhibited, meanwhile, the immunity of the organism can be greatly improved, and the occurrence probability of viral diseases in the life cycle can be reduced.

Description

Technical Field

[0001] The invention belongs to the field of compound preparations, and mainly relates to a compound preparation for inhibiting viruses and a preparation method thereof. Background Art

[0002] Once viral diseases spread among pigs, they will cause serious economic losses to the pig farm. Not only will they threaten the lives of pigs, but they will also cause a large number of pigs on the farm to become ill, with high morbidity and mortality rates, which will not only threaten the health and lives of pigs, but will also directly affect the production efficiency and economic benefits of the pig farm.

[0003] The essence of viral disease prevention and control is to improve the immunity and antiviral ability of the pig herd.

[0004] Indigo is a heat-clearing medicine. It is cold in nature, salty in taste, and belongs to the liver meridian. It clears away heat and detoxifies, and cools the blood. It is mainly used for fever and rashes, vomiting and bleeding due to blood heat, hot carbuncle, sore throat, and sores in the mouth and tongue. It mainly contains indole alkaloids such as indigo and indirubin, as well as inorganic elements such as organic acids, glycosides, iron, manganese, and zinc.

[0005] Perilla frutescens is spicy and neutral in nature. It enters the spleen, stomach and lung meridians. It has aromatic properties to eliminate dampness, invigorate the spleen and stimulate appetite, and relieve heatstroke. It is used for heatstroke and loss of appetite. Perilla frutescens contains a variety of volatile oils, alkaloids, sterols and their esters, organic acids and other ingredients. It has a variety of pharmacological effects such as promoting digestion, anti-inflammatory, and anti-pathogenic microorganisms.

[0006] Aster, pungent, bitter, warm in nature. It enters the lung meridian. It moistens the lungs and relieves qi, eliminates phlegm and relieves cough. It is used for cough, phlegm and wheezing. It mainly contains terpenoids, flavonoids, coumarins, anthraquinones, sterols, peptides, volatile oils, etc. Aster decoction has antibacterial, antiviral, and antioxidant effects. Fructus Rosae Laevigatae is sour, sweet, astringent and neutral in nature. It enters the kidney, bladder and large intestine meridians. It can consolidate the essence and reduce urine, and it can stop diarrhea by astringing the intestines. It is used for spermatorrhea, frequent urination, leucorrhea, chronic diarrhea due to spleen deficiency and chronic dysentery. It is rich in vitamins, trace elements and amino acids, and its main chemical components include polysaccharides, flavonoids, triterpenes, saponins, organic acids and the like. Among them, Fructus Rosae Laevigatae polysaccharides have the effects of improving and restoring the body's immune function, resisting stress, anti-oxidation, and inhibiting the absorption of cholesterol in the intestine. The flavonoids have significant antioxidant and immunity-enhancing effects, and the triterpenoid compounds can increase the body's metabolism.

[0007] ‌ Pyrrosia ovata tastes sweet and bitter, and is slightly cold in nature. It enters the lung and bladder meridians. It has diuretic and stranguria-relieving effects, clears the lungs and relieves cough, and cools the blood and stops bleeding. It is used for chronic bronchitis and arthritis. Pyrrosia ovata also shows antibacterial and anti-pathogenic microorganism effects, and has a certain inhibitory effect on certain bacteria and viruses.

[0008] ‌ Daphne daphne, bitter, pungent, warm; toxic. Enters the lung, spleen, and kidney meridians. It can expel water and fluid, and relieve phlegm and cough. It has the effects of diuresis, antitussive and expectorant, sedation, and promoting intestinal peristalsis.

[0009] Astragalus is sweet and slightly warm in nature. It enters the lung and spleen meridians. It replenishes qi and raises yang, consolidates the exterior and stops sweating, promotes diuresis and reduces swelling, removes toxins and discharges pus, and heals sores and regenerates muscles. It is used for lung and spleen qi deficiency, sinking of the middle qi, spontaneous sweating due to deficiency of the exterior, edema due to deficiency of qi, and sores and carbuncles that are difficult to heal and do not heal for a long time. Astragalus promotes nucleic acid metabolism; it can enhance hematopoietic function; it can improve myocardial function; it has antioxidant and antiviral effects. Among them, astragalus polysaccharides promote both nonspecific immunity and specific immunity and can enhance physical fitness. It has a significant inhibitory effect on tuberculosis infection and can play an antibacterial and antiviral effect. It can also promote the proliferation of beneficial intestinal microorganisms, and has an inhibitory effect on harmful bacteria to prevent intestinal diseases.

[0010] Rose contains volatile oil, multiple vitamins and tannic acid, etc. It has a good regulating effect on the body's endocrine system, can promote blood circulation, and has the effect of soothing the liver and regulating qi, has a good effect of regulating the spleen and stomach function, and has the effect of strengthening the spleen and replenishing qi, harmonizing the stomach and reducing adverse reactions, and eliminating dampness and stopping vomiting, and can improve digestive function and increase appetite.

[0011] The Chinese medicine in this formula is reasonably combined and fermented with rose distillate, which enhances the effect of the medicine. It can not only effectively inhibit the interference and replication of viruses, but also greatly improve the body's immunity and reduce the incidence of viral diseases during the life cycle. The raw materials used are safe, effective, and residue-free green products. Therefore, it is a good antiviral product for farmers. Summary of the invention

[0012] The purpose of the present invention is to overcome the defects of the prior art and provide a compound preparation for inhibiting viruses. The compound preparation adopts a reasonable combination of Chinese medicines and uses rose distillate for fermentation, which enhances the effect of the medicine, can not only well inhibit the interference and replication of viruses, but also greatly improve the body's immunity and reduce the incidence of viral diseases during the life cycle.

[0013] Another object of the present invention is to provide a method for preparing the above-mentioned compound preparation.

[0014] The third object of the present invention is to provide the use of the above-mentioned compound preparation in improving the body's immunity.

[0015] To achieve the above object, the present invention adopts the following technical solution: A compound preparation for inhibiting viruses (anti-virus and improving immunity), which is mainly made of the following raw materials in weight ratio: 5-10g of Indigo Naturalis, 5-10g of Perilla frutescens, 5-10g of Aster tataricus, 5-10g of Rosa laevigata, 5-10g of Pyrola serrata, 5-10g of Daphne genkwa, 5-10g of Astragalus membranaceus, 5-10g of Eucommia ulmoides, 10-15g of glucose, 3-5g of probiotics, and 3-5g of Monascus.

[0016] Specifically, the probiotics include but are not limited to one or a combination of two of Candida albicans, Lactobacillus, etc.

[0017] Further preferably, the Daphne genkwa can be Daphne genkwa made with vinegar. The method for making Daphne genkwa made with vinegar can be referred to as follows: take clean Daphne genkwa, add vinegar and mix well, stir-fry over a slow fire until the vinegar is completely absorbed, take out, and dry. Further, in the process of making Daphne genkwa made with vinegar, the mass ratio of Daphne genkwa to vinegar can be 3-5:1.

[0018] The present invention provides a method for preparing the above-mentioned compound preparation for antiviral and immunity-enhancing, which comprises the following steps: (1) Wash, dry, mix, crush, sieve, sterilize, and cool to obtain a mixture 1, which is set aside; (2) Take the washed roses and add water in a mass ratio of 1:1-2 and distill. After the oil and water in the distillate are separated, the water portion is taken, which is the rose distillate for later use; distillation conditions: distillation temperature 100±10℃, pressure maintained at 0.3-0.7MPa, distillation for 30-60 minutes; (3) Glucose, probiotics and red yeast rice are added to the rose distillate obtained in step (2) and dispersed evenly to obtain a mixture 3; the mass ratio of the sum of the mass of glucose, probiotics and red yeast rice to the mass of the rose distillate is 1:1.5-3; (4) Mix the mixture 3 and the mixture 1, place them in a fermentation tank and ferment them at a constant temperature of 36±2°C for 60-84h, dry and grind them to obtain the compound preparation product of the present invention.

[0019] In the preparation process of the above-mentioned antiviral and immunity-enhancing compound preparation, the powder in step (1) can be crushed through a 20-60 mesh sieve, and cooling means cooling to a temperature below 50°C.

[0020] The present invention provides a method for using the above-mentioned compound preparation for resisting viruses and improving immunity, which is specifically: mixed feeding, adding 0.3-0.7g of the compound preparation per 1kg of body weight, once a day, and can be used continuously.

[0021] The present invention also provides the use of the compound preparation in preparing drugs for improving the immunity and / or antiviral ability of livestock and poultry.

[0022] The present invention also provides the use of the compound preparation in preparing a drug for improving the immunity and / or antiviral ability of pigs.

[0023] Compared with the prior art, the present invention has the following advantages and beneficial effects: (1) The present invention can significantly improve the immunity of livestock and poultry and enhance the ability to inhibit viruses; (2) The present invention uses rose distillate for fermentation, which can enhance the fermentation effect and improve the bioavailability; (3) The process of the present invention is suitable for industrial production, is easily absorbed after entering the body, and is convenient for clinical administration, suitable for group administration, and saves manpower and material resources; (4) The drug content of the present invention is clear, the dosage is accurate, and the quality is controllable. DETAILED DESCRIPTION

[0024] The technical solution of the present invention is further described in detail below in conjunction with the embodiments, but the protection scope of the present invention is not limited thereto.

[0025] In the following examples, the raw materials used are all common commercial products that can be directly purchased or prepared by conventional methods in the art. For example, Candida albicans (mold activity 10 billion ≥ 10 billion / g) was purchased from Wuhan Jiangxin Biotechnology Co., Ltd., Lactobacillus (viable count ≥ 10 billion CFU / g) was purchased from Anhui Xinsheng Biotechnology Co., Ltd., and red yeast rice (morakolin K1.5%) was purchased from Yipintang Pharmaceutical Shijiazhuang Co., Ltd.

[0026] Cooling means cooling down to a temperature below 50°C.

[0027] Example 1 Preparation of a compound preparation for inhibiting viruses The compound preparation for inhibiting viruses has the following components and weight proportions: Indigo 5g, Perilla frutescens 10g, Aster 5g, Rosa laevigata 10g, Pyrola 5g, Daphne genkwa (made with vinegar) 10g, Astragalus 5g, Eucommia ulmoides 10g, Glucose 10g, Candida albicans 3g, and Monascus yeast 5g.

[0028] The preparation method of the above-mentioned compound preparation for inhibiting viruses is specifically as follows: (1) Vinegar-cooked Dahurian Flos: Take clean Dahurian Flos, add vinegar and mix well. Put it in a pot and stir-fry over low heat until the vinegar is absorbed and it turns slightly yellow. Take it out and dry it. (2) Wash, dry, mix, and grind Indigo Naturalis, Perilla frutescens, Aster tataricus, Rosa laevigata, Pyrola, Daphne genkwa (made with vinegar), Astragalus membranaceus, and Eucommia ulmoides, and pass through a 24-mesh sieve. Sterilize at 121° C. for 20 minutes, and cool to obtain a mixture 2, which is set aside. (3) Put the washed roses and purified water in a mass ratio of 1:1 into a distillation tank, heat to 100°C with steam, maintain the pressure at 0.5 MPa, and distill for 40 minutes. Then separate the distillate into oil and water and take the water portion, which is the rose distillate, for later use. (4) Glucose, Candida albicans, and red yeast rice are added to the rose distillate obtained in step (3), and the mixture is stirred and dispersed evenly to obtain a mixture 4; the mass ratio of the sum of the mass of glucose, Candida albicans, and red yeast rice to the rose distillate is 1:2; (5) Add mixed material 4 to mixed material 2, mix well, place in a fermentation tank, and ferment at a constant temperature of 36°C ± 2°C for 72 hours. Take out, dry at low temperature (45-50°C, the same below), and grind to obtain the compound preparation product of the present invention.

[0029] In the method: (1) the mass ratio of Daphne daphne to vinegar is 4:1.

[0030] Example 2 Preparation of a compound preparation for inhibiting viruses The compound preparation for inhibiting viruses has the following components and weight proportions: Indigo 10g, Perilla frutescens 5g, Aster 10g, Rosa rugosa 5g, Pyrola 10g, Daphne genkwa (made with vinegar) 5g, Astragalus 10g, Eucommia ulmoides 5g, Glucose 15g, Lactobacillus 5g, and Monascus 3g.

[0031] The preparation method of the above-mentioned compound preparation for inhibiting viruses is specifically as follows: (1) Vinegar-cooked Dahurian Flos: Take clean Dahurian Flos, add vinegar and mix well. Put it in a pot and stir-fry over low heat until the vinegar is absorbed and it turns slightly yellow. Take it out and dry it. (2) Wash, dry, mix, and grind Indigo Naturalis, Perilla frutescens, Aster tataricus, Rosa laevigata, Pyrola daphne, Daphne genkwa (made with vinegar), Astragalus membranaceus, and Eucommia ulmoides, and sterilize at 121° C. for 20 minutes to obtain a mixture 2, which is then cooled and set aside; (3) Washed roses and purified water are placed in a distillation tank in a mass ratio of 1:1, and steam-heated and pressurized distillation is performed (refer to Example 1). The distillate is subjected to oil-water separation and the water portion is taken as the rose distillate for later use; (4) Glucose, lactobacillus and red yeast rice are added to the rose distillate obtained in step (3), and stirred to be evenly dispersed to obtain a mixture 4; the mass ratio of the sum of the mass of glucose, lactobacillus and red yeast rice to the mass of the rose distillate is 1:2; (5) Add mixed material 4 to mixed material 2, mix well, place in a fermentation tank, and ferment at a constant temperature of 36°C ± 2°C for 72 hours. Take out, dry at low temperature, and crush to obtain the compound preparation product of the present invention.

[0032] In the method: (1) the mass ratio of Daphne daphne to vinegar is 4:1.

[0033] Example 3 Preparation of a compound preparation for inhibiting viruses The compound preparation for inhibiting viruses has the following components and weight proportions: Indigo 7.5g, Perilla frutescens 7.5g, Aster 7.5g, Rosa laevigata 7.5g, Pyrola 7.5g, Daphne genkwa (made with vinegar) 7.5g, Astragalus 7.5g, Eucommia 7.5g, Glucose 12.5g, Candida albicans 2g, Lactobacillus 2g, and Monascus 4g.

[0034] The preparation method of the above-mentioned compound preparation for inhibiting viruses is specifically as follows: (1) Vinegar-cooked Dahurian Flos: Take clean Dahurian Flos, add vinegar and mix well. Put it in a pot and stir-fry over low heat until the vinegar is absorbed and it turns slightly yellow. Take it out and dry it. (2) Wash, dry, mix, and grind Indigo Naturalis, Perilla frutescens, Aster tataricus, Rosa laevigata, Pyrola, Daphne genkwa (made with vinegar), Astragalus membranaceus, and Eucommia ulmoides, and pass through a 24-mesh sieve. Sterilize at 121° C. for 20 minutes, and cool to obtain a mixture 2, which is set aside. (3) Washed roses and purified water are placed in a distillation tank in a mass ratio of 1:1, and steam-heated and pressurized distillation is performed (refer to Example 1). The distillate is subjected to oil-water separation and the water portion is taken as the rose distillate for later use; (4) Glucose, Candida albicans, Lactobacillus, and Monascus koji are added to the rose distillate obtained in step (3), and stirred to be evenly dispersed to obtain a mixture 4; the mass ratio of the sum of the mass of glucose, Candida albicans, Lactobacillus, and Monascus koji to the mass of the rose distillate is 1:2; (5) Add mixed material 4 to mixed material 2, mix well, place in a fermentation tank, and ferment at a constant temperature of 36°C ± 2°C for 72 hours. Take out, dry at low temperature, and crush to obtain the compound preparation product of the present invention.

[0035] In the method: (1) the mass ratio of Daphne daphne to vinegar is 4:1.

[0036] Reference Example 1 Preparation of a reference substance for a compound preparation for inhibiting viruses The reference substance of the compound preparation for inhibiting viruses has the following components and weight proportions: Indigo 7.5g, Perilla frutescens 7.5g, Aster 7.5g, Rosa laevigata 7.5g, Pyrola 7.5g, Daphne genkwa (made with vinegar) 7.5g, Astragalus 7.5g, Eucommia 7.5g, Glucose 12.5g, Candida albicans 2g, Lactobacillus 2g, and Monascus 4g.

[0037] The preparation method of the reference substance of the above-mentioned compound preparation for inhibiting viruses is as follows: (1) Vinegar-cooked Dahurian Flos: Take clean Dahurian Flos, add vinegar and mix well. Put it in a pot and stir-fry over low heat until the vinegar is absorbed and it turns slightly yellow. Take it out and dry it. (2) Wash, dry, mix, and grind Indigo Naturalis, Perilla frutescens, Aster tataricus, Rosa laevigata, Pyrola, Daphne genkwa (made with vinegar), Astragalus, and Eucommia ulmoides, and sterilize at 121°C for 20 minutes. Cool the mixture to obtain Mixture 2 for later use; (3) Glucose, Candida albicans, Lactobacillus, and Monascus koji are added into purified water and stirred to be uniformly dispersed to obtain a mixture 3; the mass ratio of the sum of the mass of glucose, Candida albicans, Lactobacillus, and Monascus koji to the mass of purified water is 1:2; (4) Add mixed material 3 to mixed material 2, mix well, place in a fermentation tank, and ferment at a constant temperature of 36°C ± 2°C for 72 hours. Take out, dry at low temperature, and crush to obtain the product of this control example.

[0038] In the method: (1) the mass ratio of Daphne daphne to vinegar is 4:1.

[0039] Note: This control example did not use the rose distillate fermentation method.

[0040] Application experiment 1. Comparative test of the compound preparation of the present invention on pig antibodies Proceed as follows: 1. Drugs and reagents Test drug groups 1, 2, and 3: the compound preparations prepared in Examples 1, 2, and 3 were added respectively; Control drug group 1: add the reference substance of the compound preparation prepared in Control Example 1; Blank control group: no drug was added.

[0041] (II) Test methods (1) Experimental design: 200 piglets of similar parity, weight and blood relationship were selected as experimental animals and divided into 5 groups according to randomized block design, with 40 pigs in each group, including 3 experimental drug groups, 1 control drug group and 1 blank control group.

[0042] The experimental drug groups 1, 2, 3 and the control drug group were given the following dosage levels: mixed feeding, 0.5g per 1kg body weight, once a day. Blank control group: no drug was added. Free feeding was adopted, and the epidemic prevention and management measures were the same as usual. The specific method was to start giving the drug according to the above dosage 5 days before each immunization of the pigs, and continue to give the drug for 5 days as a cycle. 7 days before the second immunization, continue to use the drug for 7 days.

[0043] The observation and recording items include: the level of antibodies to classical swine fever. The indirect hemagglutination method is used to collect blood from piglets at 15 days of age (before immunization), 30 days of age (after immunization), and 70 days of age (after the second immunization) to test the level of antibodies to classical swine fever.

[0044] A hemagglutination titer of 1:16 or above indicates qualified immunity, and a hemagglutination titer of less than 1:16 indicates unqualified immunity.

[0045] (2) Results and analysis

[0046] Table 1 Results of swine fever antibody level test As can be seen from Table 1, the maternal antibody levels of the five groups were between 1:8 and 1:64, which was relatively stable. In the first test after immunization, the antibody level showed an upward trend. The test drug groups 1, 2, and 3 were significantly higher than the control drug group and the blank control group, and the antibody level was also higher, reaching more than 1:256. In the second test, the antibody level increased to varying degrees. This shows that the compound preparation of the present invention has a significant promoting effect on the improvement of swine fever antibodies and immune resistance, and the process of fermenting with rose distillate can greatly improve the effect of the product.

[0047] Application experiment 2. Comparative test on the efficacy of the compound preparation of the present invention against swine flu 1. Experimental drugs Test drug groups 1, 2, and 3: the compound preparations prepared in Examples 1, 2, and 3 were added respectively; Control drug group 1: add the control substance of the compound preparation prepared in Control Example 1.

[0048] 2. Test methods Sick pigs aged 40-60 days were selected and randomly divided into 4 groups, with 25 pigs in each group, including 3 experimental drug groups and 1 control drug group.

[0049] The main symptoms of sick pigs are body temperature reaching above 40℃, depression, loss of appetite or no appetite, difficulty breathing, often abdominal breathing, paroxysmal coughing, mucus flowing from the eyes and nose, sometimes with blood, or conjunctival congestion, dry stool, red urine, etc. It was diagnosed as influenza.

[0050] The experimental drug groups 1, 2, 3 and the control drug group were given the following dosage levels: mixed feeding, 0.5 g per kg body weight, once a day, for 7 consecutive days. The specific method was: free feeding, epidemic prevention, and management measures were consistent with daily routine.

[0051] 3. Efficacy determination and assessment indicators Cure rate: As the medication continues, clinical symptoms disappear. The percentage of cured pigs in each group to the total number of pigs with the disease is the cure rate.

[0052] Effectiveness: With the continuous use of the drug, the clinical symptoms are significantly alleviated, and it is judged to be effective if it does not affect the normal feeding of the pigs. The percentage of surviving pigs in each group to the total number of diseased pigs after the end of the test is the effective rate.

[0053] 4. Test results Clinical observation results: After administration of experimental drug groups 1, 2, and 3, the clinical manifestations of pigs were significantly improved. The condition improved on the day of medication and was effectively controlled on the 3rd day. The symptoms of the pigs were greatly improved on the 4th day. On the 6th day, they were basically cured, with normal body temperature, feeding, breathing, and drinking water, improved spirits, and normal feces.

[0054] The clinical manifestations of the pigs in the control drug group 1 improved after medication. On the third day after medication, the temperature of the pigs decreased, their appetite increased, and their coughing eased. On the fifth day after medication, the spirits of the pigs improved, their appetite increased, and their body temperature was close to normal. On the sixth day after medication, the respiratory symptoms were significantly alleviated. The specific statistical results are shown in Table 2.

[0055] Table 2 Comparative effect of the compound preparation of the present invention on swine flu As shown in Table 2, the average cure rate of the test drug groups 1, 2, and 3 is 72%, which is 80% higher than that of the control group, and the cure rate is significantly higher than that of the control group. This shows that the compound preparation of the present invention has a good therapeutic effect on swine flu, can inhibit viruses, and enhance the immunity of animal bodies, and the process of fermenting rose distillate can greatly improve the effect of the product.

Claims

1. A compound preparation for inhibiting viruses, characterized in that: The invention is mainly prepared from the following raw materials in the following weight proportions: 5-10g of Indigo Naturalis, 5-10g of Perilla frutescens, 5-10g of Aster tataricus, 5-10g of Rosa laevigata, 5-10g of Pyrola serrata, 5-10g of Daphne genkwa, 5-10g of Astragalus membranaceus, 5-10g of Eucommia ulmoides, 10-15g of glucose, 3-5g of probiotics and 3-5g of Monascus yeast.

2. The compound preparation for inhibiting viruses according to claim 1, characterized in that: The probiotics are one or a combination of Candida albicans and Lactobacillus.

3. The compound preparation for inhibiting viruses according to claim 1, characterized in that: The genkwa described is genkwa made with vinegar.

4. The compound preparation for inhibiting viruses according to claim 3, characterized in that: The method for preparing vinegar-processed genkwa is as follows: clean genkwa, add vinegar and mix well, stir-fry over a slow fire until the vinegar is completely absorbed, take out, and dry.

5. The compound preparation for inhibiting viruses according to claim 4, characterized in that: In the process of making vinegar-made genkwa, the mass ratio of genkwa to vinegar is 3-5:

1.

6. The method for preparing the compound preparation for inhibiting viruses according to any one of claims 1 to 5, characterized in that: The steps include: (1) Wash, dry, mix, crush, sieve, sterilize, and cool to obtain a mixture 1, which is set aside; (2) Take the washed rose flowers, add water and distill them. After the oil and water in the distillate are separated, take the water part, which is the rose distillate, and set it aside; (3) Glucose, probiotics and red yeast rice are added to the rose distillate obtained in step (2) and dispersed evenly to obtain a mixture 3; the mass ratio of the sum of the mass of glucose, probiotics and red yeast rice to the mass of the rose distillate is 1:1.5-3; (4) Mix mixture 3 and mixture 1, ferment at a constant temperature of 36±2℃ for 60-84h, dry and crush to obtain.

7. The method for preparing the compound preparation for inhibiting viruses according to claim 6, characterized in that: In step (1), the powder is sieved through a 20-60 mesh sieve, and cooled to a temperature below 50°C.

8. The method for using the compound preparation for inhibiting viruses according to any one of claims 1 to 5, characterized in that: Mixed feed, add 0.3-0.7g of compound preparation for every 1kg body weight, once a day.

9. Use of the compound preparation according to any one of claims 1 to 5 in the preparation of drugs for improving the immunity and / or antiviral ability of livestock and poultry.

10. Use of the compound preparation according to any one of claims 1 to 5 in the preparation of a drug for improving the immunity and / or antiviral ability of pigs.

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