Xiangsha Liujunzi decoction tablet and preparation method thereof

Abstract

The Xiangsha Liujunzi decoction tablet is prepared from the following components in parts by mass: 10 to 20 parts of ginseng (without reed), 20 to 40 parts of roasted rhizoma atractylodis macrocephalae, 20 to 40 parts of poria cocos (without peel), 7 to 15 parts of honey-fried licorice root, 9 to 18 parts of pericarpium citri reticulatae, 10 to 20 parts of processed rhizoma pinelliae, 7 to 15 parts of radix aucklandiae, 9 to 18 parts of fructus amomi, 20 to 40 parts of fresh ginger, 35 to 75 parts of lactose, 20 to 40 parts of sodium bicarbonate and 20 to 40 parts of croscarmellose sodium. And 1-2 parts of magnesium stearate. The Xiangsha Liujunzi decoction tablet prepared by the invention is small in tablet weight difference and qualified in hardness, friability and disintegration time limit.

Description

Technical Field

[0001] The invention relates to the field of medicines, and in particular to Xiangsha Liujunzi Decoction tablets and a preparation method thereof. Background Art

[0002] Xiangsha Liujunzi Decoction is a Chinese medicine prescription. It comes from the volume of "Ancient and Modern Famous Doctors' Prescriptions" - citing Ke Yunbo's prescription. It has the functions of replenishing qi and resolving phlegm, promoting qi and warming the middle. It is mainly used to treat spleen and stomach qi deficiency, phlegm blocking qi stagnation syndrome. However, this prescription is a decoction, which is inconvenient to take and bitter.

[0003] Therefore, the existing technology is in urgent need of improvement and development. Summary of the invention

[0004] In view of this, the object of the present invention is to provide Xiangsha Liujunzi Decoction tablets and a preparation method thereof, aiming to solve the problem that the existing Xiangsha Liujunzi Decoction is inconvenient to take and has a bitter taste that makes it difficult to take.

[0005] The technical solution of the present invention is as follows: Xiangsha Liujunzi Decoction vegetarian tablets, including, by weight: 10-20 parts of ginseng (without stem), 20-40 parts of stir-fried atractylodes, 20-40 parts of poria (peeled), 7-15 parts of roasted licorice, 9-18 parts of dried tangerine peel, 10-20 parts of processed pinellia, 7-15 parts of costusroot, 9-18 parts of amomum, 20-40 parts of ginger, 35-75 parts of lactose, 20-40 parts of sodium bicarbonate, 20-40 parts of cross-linked sodium carboxymethyl cellulose, and 1-2 parts of magnesium stearate.

[0006] The Xiangsha Liujunzi Decoction plain tablets include, by weight: 15 parts of ginseng (without stem), 25 parts of stir-fried atractylodes, 25 parts of poria (peeled), 10 parts of roasted licorice, 14 parts of dried tangerine peel, 15 parts of processed pinellia, 10 parts of costusroot, 15 parts of amomum, 25 parts of ginger, 60 parts of lactose, 30 parts of sodium bicarbonate, 30 parts of cross-linked sodium carboxymethyl cellulose, and 1.5 parts of magnesium stearate.

[0007] A method for preparing the above-mentioned Xiangsha Liujunzi Decoction plain tablets, comprising the steps of: (1) Crush the ginseng into coarse powder and set aside; (2) Crush the ginger into coarse powder and set aside; (3) Crush Atractylodes macrocephala, Poria cocos, roasted licorice root, dried orange peel, Pinellia ternata, and Aucklandia lappa and place them in a boiling pot. Add 6 times the amount of water, soak for 30 min, heat and boil for 60 min, and filter. Add water to the residue and continue boiling for 30 min, filter, and combine the two filtrates for later use. (4) distilling the filtrate obtained in (3) under reduced pressure at 50°C to concentrate it into an extract with a relative density of 1.08 to 1.10 for later use; (5) further concentrating the extract obtained in (4) until the relative density reaches 1.25, collecting the extract to obtain a thick paste for later use; (6) Crush Amomum villosum, soak in water for 0.5 h (the amount of water added is 7-10 times the amount of the medicinal material), and extract by steam distillation for 8 h. After filtering, let it stand for 3 h for later use; (7) Take the thick paste, add lactose, sodium bicarbonate, ginseng powder, ginger powder, and cross-linked sodium carboxymethyl cellulose, stir thoroughly, add appropriate amount of 65% ethanol to make a soft material, take out and sieve through a 16-mesh sieve for granulation, dry at below 70°C and sieve through a 16-mesh sieve again for whole granules; (8) adding magnesium stearate to the granules prepared in (7), spraying volatile oil into the granules for thorough mixing; (9) Pass (8) through a 16-mesh sieve and then compress into tablets to obtain the product. BRIEF DESCRIPTION OF THE DRAWINGS

[0008] Figure 1 The present invention is a process flow chart of the method for preparing Xiangsha Liujunzi Decoction plain tablets. Implementation

[0009] Unless otherwise defined, the technical terms used in the following examples have the same meanings as those generally understood by those skilled in the art to which the present invention belongs. The test reagents used in the following examples are conventional biochemical reagents unless otherwise specified; the experimental methods are conventional methods unless otherwise specified. The present invention is described in detail below in conjunction with the examples. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0010] The Xiangsha Liujunzi Decoction vegetarian tablets provided by the present invention comprise, by weight, 10-20 parts of ginseng (stalk removed), 20-40 parts of stir-fried atractylodes macrocephala, 20-40 parts of poria (peeled), 7-15 parts of roasted licorice, 9-18 parts of tangerine peel, 10-20 parts of processed pinellia, 7-15 parts of costusroot, 9-18 parts of amomum, 20-40 parts of ginger, 35-75 parts of lactose, 20-40 parts of sodium bicarbonate, 20-40 parts of cross-linked sodium carboxymethyl cellulose, and 1-2 parts of magnesium stearate.

[0011] The Xiangsha Liujunzi Decoction plain tablets, wherein, by weight, comprise: 15 parts of ginseng (without stem), 25 parts of stir-fried atractylodes, 25 parts of poria (peeled), 10 parts of roasted licorice, 14 parts of dried tangerine peel, 15 parts of processed pinellia, 10 parts of costusroot, 15 parts of amomum, 25 parts of ginger, 60 parts of lactose, 30 parts of sodium bicarbonate, 30 parts of cross-linked sodium carboxymethyl cellulose, and 1.5 parts of magnesium stearate. Example

[0012] 10 parts of ginseng (without stem), 20 parts of stir-fried Atractylodes macrocephala, 20 parts of Poria cocos (peeled), 7 parts of roasted licorice, 9 parts of dried orange peel, 10 parts of processed Pinellia tuber, 7 parts of costusroot, 9 parts of Amomum villosum, 20 parts of ginger, 40 parts of lactose, 20 parts of sodium bicarbonate, 20 parts of cross-linked sodium carboxymethyl cellulose, and 1 part of magnesium stearate. Example

[0013] 15 parts of ginseng (without stem), 25 parts of stir-fried atractylodes, 25 parts of poria (peeled), 10 parts of roasted licorice, 14 parts of dried tangerine peel, 15 parts of processed pinellia, 10 parts of costusroot, 15 parts of amomum, 25 parts of ginger, 60 parts of lactose, 30 parts of sodium bicarbonate, 30 parts of cross-linked sodium carboxymethyl cellulose, and 1.5 parts of magnesium stearate. Example

[0014] 20 parts of ginseng (without stem), 40 parts of stir-fried Atractylodes macrocephala, 40 parts of Poria cocos (peeled), 15 parts of roasted licorice root, 18 parts of dried orange peel, 20 parts of processed Pinellia tuber, 15 parts of costusroot, 18 parts of Amomum villosum, 40 parts of ginger, 80 parts of lactose, 40 parts of sodium bicarbonate, 40 parts of cross-linked sodium carboxymethyl cellulose, and 2 parts of magnesium stearate.

[0015] The present invention also provides a method for preparing the above-mentioned Xiangsha Liujunzi Decoction tablets, such as Figure 1 As shown, using the formulation of Example 1, the method comprises the steps of: (1) Crush the ginseng into powder, pass through an 80-mesh sieve, and set aside; (2) Crush the ginger into powder, pass through an 80-mesh sieve, and set aside; (3) Crush Atractylodes macrocephala, Poria cocos, licorice root, dried orange peel, Pinellia ternata, and Aucklandia lappa and place them in a boiling pot. Add 6 times the amount of water (i.e., 6 times the total weight of Atractylodes macrocephala, Poria cocos, licorice root, dried orange peel, Pinellia ternata, and Aucklandia lappa). Soak for 30 min, heat and boil for 60 min (starting from boiling), and filter through gauze. Add water to the residue and continue boiling for 30 min (starting from boiling), filter through gauze, and combine the two filtrates for later use. (4) The filtrate obtained in (3) is distilled under reduced pressure at 50°C to concentrate to an extract having a relative density of 1.08 to 1.10 (50°C) for later use; (5) further concentrating the extract obtained in (4) (vacuum concentration) until the relative density reaches 1.25 (50°C), collecting the extract to obtain a thick paste for later use; (6) Crush the Amomum villosum and soak it in water for 0.5 h. The amount of water added should be 7-10 times the weight of the Amomum villosum (i.e. 7-10 times the weight of the Amomum villosum, e.g. 8 times). Use steam distillation to extract for 8 h (starting from the time when water vapor is generated). After filtering, place it for 3 h (at room temperature) for later use. (7) Take the thick paste, add lactose, sodium bicarbonate, ginseng powder, ginger powder, and cross-linked sodium carboxymethyl cellulose, stir thoroughly, add appropriate amount of 65% ethanol to make a soft material, take out and sieve through a 16-mesh sieve for granulation, dry at below 70°C and sieve through a 16-mesh sieve again for whole granules; (8) adding magnesium stearate to the granules prepared in (7), spraying volatile oil into the granules for thorough mixing; (9) After passing (8) through a 16-mesh sieve, tablet compression was performed. Die: shallow concave, tablet diameter: 9 mm, tablet weight variation ±7%; hardness about 50 N; tablet surface dry, flat, without obvious defects; disintegration time: 40 minutes. Monitor the tablet weight variation during compression, and adjust the compression parameters in time if there is any deviation.

[0016] It should be understood that the application of the present invention is not limited to the above examples. For ordinary technicians in this field, improvements or changes can be made based on the above description. All these improvements and changes should fall within the scope of protection of the claims attached to the present invention.

Claims

1. Xiangsha Liujunzi Decoction Tablets, characterized in that: Measured by weight, the composition includes: 10-20 parts of ginseng (stalk removed), 20-40 parts of stir-fried atractylodes macrocephala, 20-40 parts of poria (peeled), 7-15 parts of roasted licorice root, 9-18 parts of dried tangerine peel, 10-20 parts of processed pinellia tuber, 7-15 parts of costusroot, 9-18 parts of amomum villosum, 20-40 parts of ginger, 35-75 parts of lactose, 20-40 parts of sodium bicarbonate, 20-40 parts of cross-linked sodium carboxymethyl cellulose, and 1-2 parts of magnesium stearate.

2. The Xiangsha Liujunzi Decoction plain tablet according to claim 1, characterized in that: Measured by mass, the composition includes: 15 parts of ginseng (stalk removed), 25 parts of stir-fried Atractylodes macrocephala, 25 parts of Poria cocos (peeled), 10 parts of roasted licorice root, 14 parts of dried tangerine peel, 15 parts of processed Pinellia tuber, 10 parts of costusroot, 15 parts of Amomum villosum, 25 parts of ginger, 60 parts of lactose, 30 parts of sodium bicarbonate, 30 parts of cross-linked sodium carboxymethyl cellulose, and 1.5 parts of magnesium stearate.

3. The method for preparing the Xiangsha Liujunzi Decoction Tablets according to claim 1, characterized in that: Includes steps: (1) Crush the ginseng into coarse powder for later use; (2) Crush the ginger into coarse powder and set aside; (3) Crush Atractylodes macrocephala, Poria cocos, roasted licorice root, dried orange peel, Pinellia ternata, and Aucklandia lappa and place them in a boiling pot. Add 6 times the amount of water, soak for 30 minutes, heat and boil for 60 minutes, and filter. Add water to the residue and continue boiling for 30 minutes, filter, and combine the two filtrates for later use. (4) distilling the filtrate obtained in (3) under reduced pressure at 50°C to concentrate it into an extract with a relative density of 1.08 to 1.10 for later use; (5) further concentrating the extract obtained in (4) until the relative density reaches 1.25, collecting the extract to obtain a thick paste for later use; (6) Crush Amomum villosum, soak in water for 0.5 h (the amount of water added is 7-10 times the amount of the medicinal material), and extract by steam distillation for 8 h. After filtering, let it stand for 3 h for later use; (7) Take the thick paste, add lactose, sodium bicarbonate, ginseng powder, ginger powder, and cross-linked sodium carboxymethyl cellulose, stir thoroughly, add appropriate amount of 65% ethanol to make a soft material, take out and sieve through a 16-mesh sieve for granulation, dry at below 70°C and sieve through a 16-mesh sieve again for whole granules; (8) adding magnesium stearate to the granules prepared in (7), spraying volatile oil into the granules for thorough mixing; (9) Pass (8) through a 16-mesh sieve and then compress into tablets to obtain the product.

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