A sanitary pad containing traditional Chinese medicine composition condensate explosive beads and a preparation process thereof

Abstract

The present application relates to the technical field of nursing pad, in particular to a sanitary pad containing traditional Chinese medicine composition condensation fragrance burst beads and a preparation process thereof.The sanitary pad comprises, from bottom to top, an anti-sticking paper, a waterproof layer, an absorption layer, a composite layer and an anti-sticking paper; the composite layer is obtained by placing the traditional Chinese medicine composition condensation fragrance burst beads on the first fabric layer, covering the second fabric layer, and then bonding.The traditional Chinese medicine composition in the sanitary pad can effectively inhibit Candida albicans, Escherichia coli and Staphylococcus aureus; the essential oil added in the burst fragrance condensation beads can provide a pleasant fragrance, making the sanitary pad emit fragrance, and when prepared into a nursing pad, it can effectively cover the odor of the female genital area, and also improve the antibacterial effect of the sanitary pad, resulting in lower genital itching and odor.The sanitary pad can give the user a genital area without odor and itching, which is beneficial to the physiological health of women.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of nursing pads, in particular to a sanitary pad containing a traditional Chinese medicine composition fragrance condensation pearl and a preparation process thereof. BACKGROUND

[0002] The sanitary pad is a disposable sanitary product, mainly used for absorbing and maintaining the cleanliness and dryness of the private parts. It is usually made of PE film, non-woven fabric, fluff pulp and high molecular material, etc., and has the properties of waterproofness, softness and good absorbency.

[0003] At present, it is a trend to use fragrance components and traditional Chinese medicine components in sanitary pads. Such sanitary pads have the effect of benefiting mood, and also have the effects of antibacterial, anti-inflammatory, regulating physiological cycle, relieving itching, etc. on the skin or private parts. However, there are certain technical difficulties in adding fragrance components and traditional Chinese medicine components to sanitary pads during the preparation of such sanitary pads; and the traditional Chinese medicine composition used has the defect of insufficient efficacy.

[0004] There are few sanitary pads containing traditional Chinese medicine composition fragrance condensation pearls on the market, and there are few related technical reports. Therefore, it is necessary to provide a sanitary pad containing a traditional Chinese medicine composition fragrance condensation pearl to solve the technical problems of inconvenience of adding fragrance components and traditional Chinese medicine components to sanitary pads and low efficacy of traditional Chinese medicine composition used in sanitary pads. SUMMARY

[0005] In view of the above technical problems, the present application provides a technical solution, which includes a sanitary pad containing a traditional Chinese medicine composition fragrance condensation pearl and a preparation process thereof.

[0006] On the one hand, the present application provides a traditional Chinese medicine composition, and the preparation method thereof includes:

[0007] (1) 0.5-2 parts of artemisia annua, 0.2-1.8 parts of isatidis radix, 0.2-1.5 parts of coptis, and 0.6-2.2 parts of houttuynia cordata are taken according to the mass fraction, mixed, and pulverized to less than 50 mesh to obtain a pulverized material;

[0008] (2) 10-40 times the mass of water is added to the pulverized material, heated and boiled, and then kept at 60-80℃ for 1-4 hours, and then cooled to obtain a cooled product;

[0009] (3) 800-1500 U / g of the cooled product of serratia peptidase is added to the cooled product, and enzymolysis is carried out at 50-60℃ for 2-5 hours, and then the enzyme is inactivated to obtain an enzymolysis product;

[0010] (4) Sterilize the enzymatic hydrolysis product. Add 1-4% glucose, 0.005-0.1% potassium dihydrogen phosphate, and fermentation bacteria by weight of the enzymatic hydrolysis product. Ferment at 30-40℃ for 60-90 hours, then sterilize to obtain the fermentation product. The fermentation bacteria consist of Bacillus polymyxa CICC21779 and Streptococcus thermophilus CICC 6058 in a ratio of 1:2-3, and the amount of fermentation bacteria used is (3-8)×10 9 CFU / g enzymatic hydrolysis product;

[0011] (5) Add ethanol to the fermentation product, adjust the ethanol concentration to 60-75wt%, stir at 45-60℃ for 4-7 hours, filter, ultrafilter, and dry to obtain the Chinese herbal composition.

[0012] The above composition uses Artemisia annua, Isatis indigotica, Coptis chinensis, and Houttuynia cordata, which are extracted by hot water, enzymatic hydrolysis, fermentation, and ethanol solution extraction. The resulting traditional Chinese medicine composition has excellent antibacterial effects.

[0013] On the other hand, the present invention provides a fragrant bursting bead containing a traditional Chinese medicine composition, the preparation method of which includes: stirring 0.2-0.4 parts by weight of sodium carboxymethyl cellulose and 0.5-1.5 parts by weight of water, adding 1.5-2.5 parts by weight of glycerin and stirring, then adding 0.05-0.5 parts by weight of the above-mentioned traditional Chinese medicine composition and stirring, and then adding 0.1-1 parts by weight of essential oil and stirring to obtain a mixture. The resulting mixture is loaded with a polyvinyl alcohol film as the wall material to obtain the fragrant bursting bead containing the traditional Chinese medicine composition.

[0014] Preferably, the diameter of the aroma-enhancing beads containing the traditional Chinese medicine composition is 5-7 mm, and the wall material thickness is 1.3-1.6 mm.

[0015] Among them, essential oils include at least one of rosemary essential oil, lavender essential oil, citrus essential oil, lemon essential oil, and sophora flavescens essential oil.

[0016] The aforementioned essential oils provide a pleasant fragrance, giving the product a better olfactory experience. At the same time, when made into nursing pads, they can effectively mask odors.

[0017] On the other hand, the present invention also provides a sanitary pad containing a traditional Chinese medicine composition of fragrant bursting beads, which comprises, from bottom to top: a release paper, a waterproof layer, an absorbent layer, a composite layer and a release paper.

[0018] Preferably, the composite layer is obtained by placing a fragrant bursting bead containing a traditional Chinese medicine composition on a first fabric layer, then covering it with a second fabric layer, and then bonding them together.

[0019] Preferably, the absorbent layer contains a superabsorbent resin.

[0020] In another aspect, the present application also provides a preparation method of a sanitary pad containing traditional Chinese medicine composition condensed fragrance burst beads, comprising the following steps:

[0021] S1: placing the traditional Chinese medicine composition condensed fragrance burst beads on the first fabric layer, then covering the second fabric layer, and then bonding to obtain a composite layer;

[0022] S2: arranging the release paper, waterproof layer, absorption layer, composite layer and release paper in the order from bottom to top, and then bonding and punching to obtain the sanitary pad containing traditional Chinese medicine composition condensed fragrance burst beads.

[0023] The present application has the following advantages:

[0024] The sanitary pad containing traditional Chinese medicine composition condensed fragrance burst beads provided by the present application comprises, from bottom to top, release paper, a waterproof layer, an absorption layer, a composite layer and release paper; the composite layer is obtained by placing the traditional Chinese medicine composition condensed fragrance burst beads on the first fabric layer, then covering the second fabric layer, and then bonding. The traditional Chinese medicine composition in the sanitary pad can effectively inhibit Candida albicans, Escherichia coli and Staphylococcus aureus; the essential oil added in the condensed fragrance burst beads can provide a pleasant fragrance, so that the sanitary pad emits a fragrance, and when the sanitary pad is prepared into a nursing pad, it can effectively cover the odor of the female genital area, and also improve the antibacterial effect of the sanitary pad, resulting in lower genital itching and odor. The sanitary pad of the present application can give the user a genital area without odor and itching, which is beneficial to the physiological health of women.

[0025] The prepared composition can effectively inhibit Candida albicans, and when diluted to 20%, the diameter of the inhibited Candida albicans reaches 46.74 mm, which can effectively inhibit and kill Candida albicans, giving the sanitary pad an effective defense against Candida albicans, improving the health of the body and the use effect of the sanitary pad.

[0026] The prepared composition can effectively inhibit Escherichia coli and Staphylococcus aureus, and when diluted to 20%, the diameters of the inhibited Escherichia coli and Staphylococcus aureus reach 54.95 mm and 52.13 mm, which can effectively inhibit and kill Escherichia coli and Staphylococcus aureus, giving the sanitary pad an effective defense against Escherichia coli and Staphylococcus aureus, improving the health of the body and the use effect of the sanitary pad.

[0027] The present application uses enzymolysis to increase the antibacterial effect of the traditional Chinese medicine composition, and uses serratia peptidase to adapt to the composition system of the present application, which can effectively improve the antibacterial effect of the composition; compared with other enzymes for enzymolysis, the antibacterial effect of the composition can be further improved.

[0028] The present application adopts fermentation and solvent extraction to prepare traditional Chinese medicine extract to increase the bacteriostatic effect of the extract, and the combination of Paenibacillus polymyxa CICC 21779 and Streptococcus thermophilus CICC 6058 fermentation has better effect than the composition obtained by fermentation of one of the bacteria, and the combination of the two can produce a synergistic effect, and promote the efficacy of the composition; and the ratio of the two fermentation will affect the bacteriostatic effect of the composition, especially when the ratio is 1:2-3, the effect is better.

[0029] The present application adopts alcohol solvent extraction after fermentation to further improve the bacteriostatic effect of the composition, especially when the ethanol concentration is 60-75%, the obtained composition has better bacteriostatic performance.

[0030] The present application adds essential oil in the condensation of the fragrance beads to provide a pleasant fragrance, so that the sanitary pad product has better olfactory experience, and when prepared into a care pad, it can effectively cover the odor of the female genital area, and also improve the bacteriostatic effect of the sanitary pad, and bring about lower occurrence of genital itching.

[0031] The sanitary pad prepared by the present application contains the condensation fragrance beads of the traditional Chinese medicine composition, which can make the sanitary pad not have odor and not cause itching, which is beneficial to the physiological health of women.

[0032] The sanitary pad prepared by the present application has excellent effect and good application prospect. DETAILED DESCRIPTION

[0033] The specific embodiments will be described below, and the various effects of the present application will be more clearly presented. Those skilled in the art should understand that these specific embodiments are used to illustrate the present application, not to limit the present application.

[0034] Paenibacillus polymyxa CICC 21779 and Streptococcus thermophilus CICC 6058 were purchased from China Industrial Microbial Strain Preservation and Management Center. Serrapeptase was purchased from Shanxi Zhongnuo Biological Technology Co., Ltd. Bromelain was purchased from Xi'an Musen Biological Engineering Co., Ltd.

[0035] I. Preparation of traditional Chinese medicine composition

[0036] Composition 1:

[0037] The preparation process is as follows: (1) according to the quality parts of the dry product, take 1.5 parts of Artemisia annua leaves, 1 part of Isatidis radix, 1 part of Coptidis rhizoma, 2 parts of Houttuynia cordata leaves, mix, crush to less than 50 mesh, and obtain the crushed material;

[0038] (2), add 20 times mass of water to the pulverized material, heat and boil, keep at 70℃, 60rpm for 2.8 hours, then cool to room temperature to obtain a cooled product;

[0039] (3), add 1100U / g of the cooled product of serralysin to the cooled product, enzymolysis at 55℃ for 3.7 hours, inactivate the enzyme to obtain an enzymolysis product;

[0040] (4), sterilize the enzymolysis product, add 2.6% of the mass of the enzymolysis product of glucose, 0.045% of potassium dihydrogen phosphate and fermentation bacteria, anaerobic fermentation at 37℃, 50rpm for 82 hours, then sterilize to obtain a fermentation product; the fermentation bacteria are composed of Paenibacillus polymyxa CICC21779 and Streptococcus thermophilus CICC 6058 in a quantity ratio of 1:2.5, and the amount of the fermentation bacteria is 7.70×10 9 cfu / g of the enzymolysis product;

[0041] (5), add ethanol to the fermentation product to adjust the ethanol concentration to 72wt%, stir at 50℃, 70rpm for 5.5 hours, filter through a 0.5 micron filter membrane, ultrafiltrate through a molecular weight throttling membrane of 1500Da, and dry at 70℃ until the water content is 1.65wt% to obtain a traditional Chinese medicine composition.

[0042] Composition 2:

[0043] The preparation process is as follows: (1), according to the mass parts of the dried product, take 2 parts of Artemisia annua leaves, 0.5 parts of Radix Isatidis, 1.2 parts of Rhizoma Coptidis, and 1 part of Houttuynia cordata Thunb. leaves, mix and pulverize to less than 50 mesh to obtain a pulverized material;

[0044] (2), add 22 times mass of water to the pulverized material, heat and boil, keep at 70℃, 60rpm for 2.4 hours, then cool to room temperature to obtain a cooled product;

[0045] (3), add 1000U / g of the cooled product of serralysin to the cooled product, enzymolysis at 55℃ for 3.5 hours, inactivate the enzyme to obtain an enzymolysis product;

[0046] (4), sterilize the enzymolysis product, add 2.6% of the mass of the enzymolysis product of glucose, 0.045% of potassium dihydrogen phosphate and fermentation bacteria, anaerobic fermentation at 37℃, 50rpm for 82 hours, then sterilize to obtain a fermentation product; the fermentation bacteria are composed of Paenibacillus polymyxa CICC21779 and Streptococcus thermophilus CICC 6058 in a quantity ratio of 1:2.5, and the amount of the fermentation bacteria is 7.70×10 9 cfu / g of the enzymolysis product;

[0047] (5), add ethanol to the fermentation product, adjust the ethanol concentration to 65wt%, 50℃, 70rpm stirring for 5 hours, 0.5 micron filter membrane filtration, throttle molecular weight 1500Da ultrafiltration membrane ultrafiltration, 70℃ drying to moisture content 1.69wt%, to obtain the traditional Chinese medicine composition.

[0048] Composition 3:

[0049] The preparation process is as follows: (1) according to the mass fraction of dry product, take 1.5 parts of artemisia annua leaf, 1 part of isatis root, 1 part of corydalis, 2 parts of houttuynia cordata leaf, mix, crush to less than 50 mesh, get the crushed material;

[0050] (2), add 20 times mass of water to the crushed material, heat to boiling, 70℃, 60rpm, 2.8 hours, then cool to room temperature, get the cooled product;

[0051] (3), sterilize the cooled product, add 2.6% of the cooling mass of glucose, 0.045% of potassium dihydrogen phosphate and fermentation bacteria, 37℃, 50rpm anaerobic fermentation for 82 hours, then sterilize, get the fermentation product; the fermentation bacteria are composed of bacillus polymyxa CICC 21779 and streptococcus thermophilus CICC 6058 according to the quantity ratio of 1:2.5, the amount of fermentation bacteria is 7.70x10 9 cfu / g of cooled product;

[0052] (4), add ethanol to the fermentation product, adjust the ethanol concentration to 72wt%, 50℃, 70rpm stirring for 5.5 hours, 0.5 micron filter membrane filtration, throttle molecular weight 1500Da ultrafiltration membrane ultrafiltration, 70℃ drying to moisture content 1.65wt%, to obtain the traditional Chinese medicine composition.

[0053] Composition 4:

[0054] The preparation process is as follows: (1) according to the mass fraction of dry product, take 1.5 parts of artemisia annua leaf, 1 part of isatis root, 1 part of corydalis, 2 parts of houttuynia cordata leaf, mix, crush to less than 50 mesh, get the crushed material;

[0055] (2), add 20 times mass of water to the crushed material, heat to boiling, 70℃, 60rpm, 2.8 hours, then cool to room temperature, get the cooled product;

[0056] (3), add 1100U / g of bromelain to the cooled product, 55℃, 3.7 hours, inactivate the enzyme, get the enzyme hydrolysate;

[0057] (4), sterilize the enzymatic hydrolysate, add 2.6% glucose, 0.045% potassium dihydrogen phosphate and fermentation bacteria to the enzymatic hydrolysate, and then perform anaerobic fermentation at 37°C and 50 rpm for 82 hours, and then sterilize to obtain a fermentation product; the fermentation bacteria are composed of Paenibacillus polymyxa CICC21779 and Streptococcus thermophilus CICC 6058 in a quantity ratio of 1:2.5, and the amount of the fermentation bacteria is 7.70x10 9 cfu / g of the enzymatic hydrolysate;

[0058] (5), add ethanol to the fermentation product, adjust the ethanol concentration to 72wt%, stir at 50°C and 70 rpm for 5.5 hours, filter through a 0.5 micron filter membrane, ultrafilter through a throttle molecular weight 1500 Da ultrafilter membrane, and dry at 70°C until the water content is 1.65wt% to obtain a traditional Chinese medicine composition.

[0059] Composition 5:

[0060] The preparation process is as follows: (1) according to the mass parts of the dry product, take 1.5 parts of Artemisia annua leaves, 1 part of Radix Isatidis, 1 part of Rhizoma Coptidis, and 2 parts of Houttuynia cordata leaves, mix them, and crush them to less than 50 mesh to obtain a crushed product;

[0061] (2), add 20 times the mass of water to the crushed product, heat and boil, and then incubate at 70°C and 60 rpm for 2.8 hours, and then cool to room temperature to obtain a cooled product;

[0062] (3), add 1100 U / g of Serratiopeptidase to the cooled product, and then perform enzymatic hydrolysis at 55°C for 3.7 hours, and then inactivate the enzyme to obtain an enzymatic hydrolysate;

[0063] (4), add ethanol to the enzymatic hydrolysate, adjust the ethanol concentration to 72wt%, stir at 50°C and 70 rpm for 5.5 hours, filter through a 0.5 micron filter membrane, ultrafilter through a throttle molecular weight 1500 Da ultrafilter membrane, and dry at 70°C until the water content is 1.65wt% to obtain a traditional Chinese medicine composition.

[0064] Composition 6:

[0065] The preparation process is as follows: (1) according to the mass parts of the dry product, take 1.5 parts of Artemisia annua leaves, 1 part of Radix Isatidis, 1 part of Rhizoma Coptidis, and 2 parts of Houttuynia cordata leaves, mix them, and crush them to less than 50 mesh to obtain a crushed product;

[0066] (2), add 20 times the mass of water to the crushed product, heat and boil, and then incubate at 70°C and 60 rpm for 2.8 hours, and then cool to room temperature to obtain a cooled product;

[0067] (3), add 1100 U / g of Serratiopeptidase to the cooled product, and then perform enzymatic hydrolysis at 55°C for 3.7 hours, and then inactivate the enzyme to obtain an enzymatic hydrolysate;

[0068] (4), sterilize the enzymatic hydrolysate, add 2.6% glucose, 0.045% potassium dihydrogen phosphate and fermentation bacteria to the enzymatic hydrolysate, anaerobic fermentation at 37℃ and 50 rpm for 82 hours, then sterilize to obtain the fermentation product; the fermentation bacteria is Streptococcus thermophilus CICC6058, and the amount of the fermentation bacteria is 7.70 x 10 9 cfu / g of the enzymatic hydrolysate;

[0069] (5), add ethanol to the fermentation product, adjust the ethanol concentration to 72wt%, stir at 50℃ and 70 rpm for 5.5 hours, filter through a 0.5 micron filter membrane, ultrafiltrate through a throttle molecular weight 1500 Da ultrafiltration membrane, and dry at 70℃ until the water content is 1.65wt% to obtain the traditional Chinese medicine composition.

[0070] Composition 7:

[0071] The preparation process is as follows: (1) according to the mass parts of the dry product, take 1.5 parts of Artemisia annua leaves, 1 part of Radix Isatidis, 1 part of Rhizoma Coptidis, and 2 parts of Houttuynia cordata Thunb. leaves, mix, and crush to less than 50 mesh to obtain a crushed product;

[0072] (2), add 20 times the mass of water to the crushed product, heat and boil, and then incubate at 70℃ and 60 rpm for 2.8 hours, and then cool to room temperature to obtain a cooled product;

[0073] (3), add 1100 U / g of the cooled product of serratia peptidase to the cooled product, and enzymatically hydrolyze at 55℃ for 3.7 hours, and then inactivate the enzyme to obtain an enzymatic hydrolysate;

[0074] (4), sterilize the enzymatic hydrolysate, add 2.6% glucose, 0.045% potassium dihydrogen phosphate and fermentation bacteria to the enzymatic hydrolysate, anaerobic fermentation at 37℃ and 50 rpm for 82 hours, then sterilize to obtain the fermentation product; the fermentation bacteria is Streptococcus thermophilus CICC6058, and the amount of the fermentation bacteria is 7.70 x 10 9 cfu / g of the enzymatic hydrolysate;

[0075] (5), add ethanol to the fermentation product, adjust the ethanol concentration to 72wt%, stir at 50℃ and 70 rpm for 5.5 hours, filter through a 0.5 micron filter membrane, ultrafiltrate through a throttle molecular weight 1500 Da ultrafiltration membrane, and dry at 70℃ until the water content is 1.65wt% to obtain the traditional Chinese medicine composition.

[0076] Composition 8:

[0077] The preparation process is as follows: (1) according to the mass parts of the dry product, take 1.5 parts of Artemisia annua leaves, 1 part of Radix Isatidis, 1 part of Rhizoma Coptidis, and 2 parts of Houttuynia cordata Thunb. leaves, mix, and crush to less than 50 mesh to obtain a crushed product;

[0078] (2), add 20 times mass of water to the pulverized material, heat and boil, keep at 70℃, 60rpm for 2.8 hours, then cool to room temperature to obtain a cooled product;

[0079] (3), add 1100U / g of the cooled product of serralysin to the cooled product, enzymolysis at 55℃ for 3.7 hours, inactivate the enzyme to obtain an enzymolysis product;

[0080] (4), sterilize the enzymolysis product, add 2.6% of glucose, 0.045% of potassium dihydrogen phosphate and fermentation bacteria to the mass of the enzymolysis product, anaerobic fermentation at 37℃, 50rpm for 82 hours, then sterilize to obtain a fermentation product; the fermentation bacteria are composed of Paenibacillus polymyxa CICC21779 and Streptococcus thermophilus CICC 6058 in a quantity ratio of 1:0.5, and the amount of the fermentation bacteria is 7.70×10 9 cfu / g of the enzymolysis product;

[0081] (5), add ethanol to the fermentation product to adjust the ethanol concentration to 72wt%, stir at 50℃, 70rpm for 5.5 hours, filter through a 0.5 micron filter membrane, ultrafiltrate through a molecular weight throttling membrane of 1500Da, and dry at 70℃ until the water content is 1.65wt% to obtain a traditional Chinese medicine composition.

[0082] Composition 9:

[0083] The preparation process is as follows: (1), according to the mass parts of the dried product, take 1.5 parts of Artemisia annua leaves, 1 part of Radix Isatidis, 1 part of Rhizoma Coptidis, and 2 parts of Houttuynia cordata Thunb. leaves, mix and pulverize to less than 50 mesh to obtain a pulverized material;

[0084] (2), add 20 times mass of water to the pulverized material, heat and boil, keep at 70℃, 60rpm for 2.8 hours, then cool to room temperature to obtain a cooled product;

[0085] (3), add 1100U / g of the cooled product of serralysin to the cooled product, enzymolysis at 55℃ for 3.7 hours, inactivate the enzyme to obtain an enzymolysis product;

[0086] (4), sterilize the enzymolysis product, add 2.6% of glucose, 0.045% of potassium dihydrogen phosphate and fermentation bacteria to the mass of the enzymolysis product, anaerobic fermentation at 37℃, 50rpm for 82 hours, then sterilize to obtain a fermentation product; the fermentation bacteria are composed of Paenibacillus polymyxa CICC21779 and Streptococcus thermophilus CICC 6058 in a quantity ratio of 1:6, and the amount of the fermentation bacteria is 7.70×10 9 cfu / g of the enzymolysis product;

[0087] (5), add ethanol to the fermentation product, adjust the ethanol concentration to 72wt%, 50℃, 70rpm stirring for 5.5 hours, 0.5 micron filter membrane filtration, throttle molecular weight 1500Da ultrafiltration membrane ultrafiltration, 70℃ drying to moisture content 1.65wt%, to obtain traditional Chinese medicine composition.

[0088] Composition 10:

[0089] The preparation process is as follows: (1) according to the mass fraction of dry product, take 1.5 parts of artemisia annua leaf, 1 part of radix isatidis, 1 part of rhizoma coptidis, 2 parts of houttuynia cordata leaf, mix, crush to less than 50 mesh, get the crushed material;

[0090] (2), add 20 times the mass of water to the crushed material, heat to boiling, 70℃, 60rpm for 2.8 hours, then cool to room temperature, get the cooled product;

[0091] (3), add 1100U / g of the cooled product of serralysin to the cooled product, 55℃ for 3.7 hours, inactivate the enzyme, get the enzyme hydrolysate;

[0092] (4), sterilize the enzyme hydrolysate, add 2.6% glucose, 0.045% potassium dihydrogen phosphate and fermentation bacteria to the enzyme hydrolysate, 37℃, 50rpm anaerobic fermentation for 82 hours, then sterilize, get the fermentation product; the fermentation bacteria are composed of bacillus polymyxa CICC21779 and streptococcus thermophilus CICC 6058 according to the quantity ratio of 1:2.5, the amount of fermentation bacteria is 7.70×10 9 cfu / g of enzyme hydrolysate;

[0093] (5), add ethanol to the fermentation product, adjust the ethanol concentration to 95wt%, 50℃, 70rpm stirring for 5.5 hours, 0.5 micron filter membrane filtration, throttle molecular weight 1500Da ultrafiltration membrane ultrafiltration, 70℃ drying to moisture content 1.65wt%, to obtain traditional Chinese medicine composition.

[0094] Composition 11:

[0095] The preparation process is as follows: (1) according to the mass fraction of dry product, take 1.5 parts of artemisia annua leaf, 1 part of radix isatidis, 1 part of rhizoma coptidis, 2 parts of houttuynia cordata leaf, mix, crush to less than 50 mesh, get the crushed material;

[0096] (2), add 20 times the mass of water to the crushed material, heat to boiling, 70℃, 60rpm for 2.8 hours, then cool to room temperature, get the cooled product;

[0097] (3), add 1100U / g of the cooled product of serralysin to the cooled product, 55℃ for 3.7 hours, inactivate the enzyme, get the enzyme hydrolysate;

[0098] (4), sterilize the enzymatic hydrolysate, add 2.6% glucose, 0.045% potassium dihydrogen phosphate and fermentation bacteria to the enzymatic hydrolysate, and then perform anaerobic fermentation at 37°C and 50 rpm for 82 hours, and then sterilize to obtain a fermentation product; the fermentation bacteria are composed of Paenibacillus polymyxa CICC 21779 and Streptococcus thermophilus CICC 6058 in a quantity ratio of 1:2.5, and the amount of the fermentation bacteria is 7.70 x 10 9 cfu / g of the enzymatic hydrolysate;

[0099] (5), add ethanol to the fermentation product, adjust the ethanol concentration to 20 wt%, stir at 50°C and 70 rpm for 5.5 hours, filter through a 0.5-micron filter membrane, ultrafilter through a molecular weight throttling membrane with a molecular weight of 1500 Da, and dry at 70°C until the water content is 1.65 wt% to obtain the traditional Chinese medicine composition.

[0100] II. Performance test of the composition

[0101] 1. Candida albicans inhibition test: test the inhibition effect of a dilution of the above-mentioned composition on Candida albicans CMCC(F) 98001.

[0102] Test method: dilute the above-mentioned composition to a mass concentration of 20% using Tween 60 with a mass concentration of 7% to obtain a sample solution. Take 200 μL of a bacterial solution with a concentration of 5.5 x 10 6 cfu / mL to a plate (obtained by pouring YPD medium into a sterile flat dish and stirring to solidify), spread evenly to obtain a bacterial-containing plate. Take a blank drug sensitivity sheet with a diameter of 6.5 mm and a thickness of 0.55 mm, immerse it in the above-mentioned sample solution for 25 minutes, take it out, remove the unabsorbed sample solution, and then place it in the center of the bacterial-containing plate. Incubate at 37°C for 24 hours, and test the diameter of the inhibition zone; each group is tested in parallel for 4 times, and the average value is taken. The results of the Candida albicans inhibition test are shown in Table 1.

[0103] Table 1: Candida albicans inhibition test

[0104] Test / mm C. albicans Composition 1 46.74 Composition 2 45.98 Composition 3 38.15 Composition 4 43.71 Composition 5 31.94 Composition 6 38.26 Composition 7 39.83 Composition 8 44.12 Composition 9 42.65 Composition 10 39.47 Composition 11 41.39

[0105] 2. Escherichia coli and Staphylococcus aureus inhibition test: test method: dilute the above-mentioned composition to a mass concentration of 20% using Tween 60 with a mass concentration of 7% to obtain a sample solution. Take 200 μL of a bacterial solution with a concentration of 5.5 x 10 6200 μL of the bacterial solution was taken to the plate (using YPD medium poured into a sterile flat dish, shaken and solidified) and evenly spread to obtain a bacterial-containing plate. A 6.5 mm diameter, 0.55 mm thick blank drug sensitivity sheet was immersed in the above sample solution for 25 minutes, taken out, and the unabsorbed sample solution was removed, and then placed in the center of the bacterial-containing plate. Incubate at 37°C for 24 hours, test the diameter of the inhibition zone; each group is tested in parallel for 4 times, and the average value is taken. The test results of inhibiting E. coli and S. aureus are shown in Table 2.

[0106] Table 2: Inhibition of E. coli and S. aureus test

[0107] Test / mm E. coli S. aureus Composition 1 54.95 52.13 Composition 2 54.03 51.22 Composition 3 44.67 42.45 Composition 4 51.34 48.70 Composition 5 37.26 35.41 Composition 6 44.81 42.56 Composition 7 46.69 44.32 Composition 8 51.83 49.17 Composition 9 50.02 47.54 Composition 10 46.26 43.91 Composition 11 48.58 46.08

[0108] Candida albicans is a common Candida fungus. When the body's defense mechanism is weakened or external factors interfere, Candida albicans can multiply in large numbers and cause infection. Candida albicans infection mainly manifests as vaginal itching, vulva swelling, white clumpy secretions, urethral burning, sexual intercourse pain, etc.; patients with mild symptoms may only have mild vaginal itching and increased leukorrhea. Therefore, when providing sanitary pads, it is necessary for the sanitary pad to have effective Candida albicans inhibition effect for female users.

[0109] According to Table 1 test, the composition prepared by the application can effectively inhibit Candida albicans. When diluted to 20%, the diameter of the Candida albicans inhibition produced is 46.74 mm, which can effectively inhibit and kill Candida albicans, endow the sanitary pad with effective Candida albicans defense effect, and improve the health of the body and the use effect of the sanitary pad.

[0110] E. coli is a gram-negative bacterium that exists in the intestines of humans and animals; in particular, some specific E. coli can produce toxins, causing food poisoning and serious intestinal diseases; S. aureus is a gram-positive bacterium, which can cause skin infections or skin diseases such as boils, abscesses, and food poisoning. Therefore, in the textile or sanitary pad industry, E. coli and S. aureus are commonly used as detection indicators.

[0111] According to Table 2 test, the composition prepared by the application can effectively inhibit E. coli and S. aureus. When diluted to 20%, the diameters of the E. coli and S. aureus inhibition produced are 54.95 mm and 52.13 mm, respectively, which can effectively inhibit and kill E. coli and S. aureus, endow the sanitary pad with effective E. coli and S. aureus defense effect, and improve the health of the body and the use effect of the sanitary pad.

[0112] It is one of the common research contents to increase the bacteriostatic effect of traditional Chinese medicine composition by enzymolysis at present, and it is particularly important to select appropriate enzymes for enzymolysis according to different drugs and different types of inhibited bacteria. According to the test results of compositions 1, 3-4 in Tables 1-2, it can be known that the serratia peptidase adopted in the present application is suitable for the composition system of the present application, and can effectively improve the bacteriostatic effect of the composition; compared with other enzymes for enzymolysis, the bacteriostatic effect of the composition can be further improved.

[0113] It is one of the research means in the traditional Chinese medicine industry to prepare traditional Chinese medicine extract by fermentation and solvent extraction in order to increase the bacteriostatic effect of the extract; and the enrichment effect and richness of the bacteriostatic active ingredients are different for different fermentation bacteria and solvent types and concentrations; therefore, appropriate bacteria and solvent types and concentrations need to be selected according to specific targets. The present application adopts combined fermentation of Paenibacillus polymyxa CICC 21779 and Streptococcus thermophilus CICC 6058, and the composition obtained by fermentation of one of the bacteria has better effect; the two bacteria have a synergistic effect and promote each other to improve the efficacy of the composition; the above content can be known from the test results of compositions 1, 6-7; and the ratio of the two bacteria for fermentation also affects the bacteriostatic effect of the composition, especially when the ratio is 1:2-3, the effect is better; the above results can be obtained from the test results of compositions 1, 8-9. At the same time, after fermentation, the present application adopts alcohol solvent extraction to further improve the bacteriostatic effect of the composition; especially when the ethanol concentration is 60-75%, the bacteriostatic performance of the obtained composition is better; the above results can be obtained from the test results of compositions 1, 10-11.

[0114] III. Sanitary pad and test

[0115] 1. Sanitary pad

[0116] Sanitary pad 1:

[0117] The preparation method is as follows:

[0118] (1) Preparation of condensation fragrance burst beads: according to mass parts, 0.3 parts of sodium carboxymethyl cellulose and 0.6 parts of water are stirred, 1.7 parts of glycerol is added and stirred, then 0.1 parts of the above prepared composition 1 is added and stirred, and then 0.2 parts of essential oil (composed of rosemary essential oil, lavender essential oil and citrus essential oil according to a mass ratio of 1:0.5:0.5) is added and stirred to obtain a mixture, the obtained mixture is loaded with polyvinyl alcohol film as a wall material to obtain condensation fragrance burst beads with a diameter of about 6 mm and a wall material thickness of about 1.5 mm containing traditional Chinese medicine composition condensation fragrance burst beads.

[0119] (2) The traditional Chinese medicine composition condensation fragrance burst beads are placed on the first fabric layer, then the second fabric layer is covered, and then bonding is performed to obtain a composite layer.

[0120] (3) The release paper, waterproof layer, absorbent layer containing water-absorbing resin, composite layer and release paper are arranged in order from bottom to top, then bonded and punched to obtain the sanitary pad containing the Chinese herbal composition of fragrant bursting beads.

[0121] Sanitary pad 2:

[0122] The preparation method is as follows:

[0123] (1) Preparation of aroma-enhancing beads: According to the mass parts, 0.35 parts of sodium carboxymethyl cellulose and 0.7 parts of water are stirred, 1.9 parts of glycerin are added and stirred, then 0.12 parts of the above-prepared composition 2 are added and stirred, and then 0.25 parts of essential oil (composed of rosemary essential oil, lavender essential oil, citrus essential oil, lemon essential oil and sophora flavescens essential oil in a mass ratio of 1:1:1:1:1) are added and stirred to obtain a mixture. The resulting mixture is loaded with a polyvinyl alcohol film as the wall material to obtain aroma-enhancing beads with a diameter of about 6 mm and a wall material thickness of about 1.5 mm containing the traditional Chinese medicine composition.

[0124] (2) Place the fragrant burst beads containing the Chinese medicine composition on the first fabric layer, then cover the second fabric layer, and then bond them together to obtain a composite layer.

[0125] (3) The release paper, waterproof layer, absorbent layer containing water-absorbing resin, composite layer and release paper are arranged in order from bottom to top, then bonded and punched to obtain the sanitary pad containing the Chinese herbal composition of fragrant bursting beads.

[0126] Sanitary Panty Liner 3: Fragrance-free, without the added fragrance of scented beads.

[0127] The preparation method is as follows:

[0128] (1) Preparation of aroma-enhancing burst beads: According to the mass parts, 0.3 parts of sodium carboxymethyl cellulose and 0.6 parts of water are stirred, 1.7 parts of glycerin are added and stirred, and then 0.1 parts of the above-prepared composition 1 are added and stirred to obtain a mixture. The mixture is loaded with polyvinyl alcohol film as wall material to obtain aroma-enhancing burst beads with a diameter of about 6 mm and a wall material thickness of about 1.5 mm containing the Chinese medicine composition.

[0129] (2) Place the popping beads on the first fabric layer, then cover the second fabric layer, and then bond them together to obtain a composite layer.

[0130] (3) The release paper, waterproof layer, absorbent layer containing water-absorbing resin, composite layer and release paper are arranged in order from bottom to top, then bonded and punched to obtain the sanitary pad containing the Chinese herbal composition of fragrant bursting beads.

[0131] Sanitary pad 4: The difference from sanitary pad 1 is that the composite layer does not use the fragrant burst beads containing Chinese herbal composition, otherwise they are the same.

[0132] 2. Test of sanitary pad

[0133] 20 healthy female volunteers aged 25-35 years old were recruited and randomly divided into 4 groups, 5 people in each group, using the above sanitary pad for 3 months, and then scoring each index, with a maximum of 10 points and a minimum of 0 points; Test indexes include: odor, degree of vulvar itching; The lower the odor level, the higher the score; The lower the degree of vulvar itching, the higher the score. The average score of the specific test results is shown in Table 3.

[0134] Table 3: Sanitary pad test

[0135] Test Sanitary pad 1 Sanitary pad 2 Sanitary pad 3 Sanitary pad 4 Odor 9.7 9.7 8.5 8.0 Vulvar itching 9.6 9.7 8.1 7.2

[0136] According to the sanitary pad 1-4 test in Table 3, the sanitary pad prepared without containing the fragrance condensing beads and without using essential oil in the fragrance condensing beads can improve the degree of vulvar odor and itching. It can be seen that the present application adds essential oil to the fragrance condensing beads, which can provide a pleasant fragrance, so that the sanitary pad product has a good olfactory experience, at the same time, when prepared into a care pad, it can effectively cover the odor of the female vulva, and also can improve the antibacterial effect of the sanitary pad, and bring about lower occurrence of vulvar itching.

[0137] The sanitary pad prepared by the present application contains the condensing fragrance beads of the traditional Chinese medicine composition, which can make the sanitary pad give the user no odor and no itching, which is beneficial to the physiological health of women.

[0138] Obviously, those skilled in the art can make various modifications and variations to the present application without departing from the spirit and scope of the present application. Thus, if these modifications and variations of the present application fall within the scope of the claims of the present application and their equivalents, the present application also intends to include these modifications and variations.

Claims

1. A method for preparing aroma-enhancing capsules containing a traditional Chinese medicine composition, characterized in that, The preparation methods of traditional Chinese medicine compositions include: (1), taking 0.5-2 parts of Artemisia annua, 0.2-1.8 parts of Radix Isatidis, 0.2-1.5 parts of Rhizoma Coptidis, and 0.6-2.2 parts of Houttuynia cordata by mass fraction, mixing, crushing to less than 50 mesh, to obtain a crushed product; (2), adding 10-40 times the mass of water to the crushed product, heating to boiling, keeping at 60-80°C for 1-4 hours, then cooling to obtain a cooled product; (3), adding 800-1500 U / g of the cooled product of serralysin to the cooled product, enzymolysis at 50-60°C for 2-5 hours, enzyme inactivation, to obtain an enzymolysis product; (4), sterilizing the enzymolysis product, adding 1-4% of glucose, 0.005-0.1% of potassium dihydrogen phosphate, and fermentation bacteria to the mass of the enzymolysis product, fermenting at 30-40°C for 60-90 hours, then sterilizing, to obtain a fermentation product; the fermentation bacteria are composed of Bacillus polymyxa CICC 21779 and Streptococcus thermophilus CICC 6058 in a quantity ratio of 1:2-3, and the amount of the fermentation bacteria is (3-8) x 10 9 cfu / g of the enzymolysis product; (5), adding ethanol to the fermentation product, adjusting the ethanol concentration to 60-75 wt%, stirring at 45-60°C for 4-7 hours, filtering, ultrafiltrating, and drying, to obtain the traditional Chinese medicine composition. The preparation method of the aroma-enhancing beads containing the traditional Chinese medicine composition includes: stirring 0.2-0.4 parts of sodium carboxymethyl cellulose and 0.5-1.5 parts of water according to the mass ratio, adding 1.5-2.5 parts of glycerin and stirring, then adding 0.05-0.5 parts of the traditional Chinese medicine composition and stirring, and then adding 0.1-1 parts of essential oil and stirring to obtain a mixture. The resulting mixture is loaded with a polyvinyl alcohol film as the wall material to obtain the aroma-enhancing beads containing the traditional Chinese medicine composition.

2. The production method according to claim 1, characterized by, The diameter of the fragrant burst beads containing the Chinese herbal composition is 5-7mm, and the wall material thickness is 1.3-1.6mm.

3. The production method according to claim 1 or 2, characterized by, Essential oils include at least one of rosemary essential oil, lavender essential oil, citrus essential oil, lemon essential oil, and sophora flavescens essential oil.

4. A fragrant bursting bead containing a traditional Chinese medicine composition prepared by the preparation method according to any one of claims 1-3.

5. A method for preparing a sanitary pad containing a traditional Chinese medicine composition condensate fragrance burst bead, characterized in that, The sanitary pad containing herbal extract-infused beads comprises, from bottom to top: release paper, waterproof layer, absorbent layer, composite layer, and release paper again; the composite layer is formed by placing the herbal extract-infused beads on the first fabric layer, then covering it with the second fabric layer, and finally bonding them together; the herbal extract-infused beads have a diameter of 5-7 mm and a wall thickness of 1.3-1.6 mm; the absorbent layer contains superabsorbent resin; The preparation method of sanitary pads containing herbal composition fragrance burst beads includes: S1: placing the herbal composition fragrance burst beads on the first fabric layer, then covering the second fabric layer, and then bonding them together to obtain a composite layer; S2: arranging the release paper, waterproof layer, absorbent layer, composite layer and release paper in the order from bottom to top, then bonding them together, and punching holes to obtain sanitary pads containing herbal composition fragrance burst beads; The preparation method of the traditional Chinese medicine composition comprises: (1) taking 0.5-2 parts of artemisia, 0.2-1.8 parts of isatis root, 0.2-1.5 parts of coptis, and 0.6-2.2 parts of houttuynia cordata by mass fraction, mixing, crushing to less than 50 mesh, and obtaining a crushed product; (2) adding 10-40 times the mass of water to the crushed product, heating and boiling, and keeping the temperature at 60-80 DEG C for 1-4 hours, then cooling to obtain a cooled product; (3) adding 800-1500 U / g of the cooled product of serratia peptidase to the cooled product, and enzymolysis at 50-60 DEG C for 2-5 hours, then inactivating the enzyme to obtain an enzymolysis product; (4) sterilizing the enzymolysis product, adding 1-4% of the mass of the enzymolysis product of glucose, 0.005-0.1% of potassium dihydrogen phosphate, and fermentation bacteria, and fermenting at 30-40 DEG C for 60-90 hours, then sterilizing to obtain a fermentation product; the fermentation bacteria are composed of bacillus polymyxa CICC 21779 and streptococcus thermophilus CICC 6058 in a quantity ratio of 1:2-3, and the amount of the fermentation bacteria is (3-8) x 10 9 cfu / g of the enzymolysis product; (5) adding ethanol to the fermentation product, adjusting the ethanol concentration to 60-75 wt%, stirring at 45-60 DEG C for 4-7 hours, filtering, ultrafiltering, and drying to obtain the traditional Chinese medicine composition. The preparation method of the aroma-enhancing beads containing the traditional Chinese medicine composition includes: stirring 0.2-0.4 parts of sodium carboxymethyl cellulose and 0.5-1.5 parts of water according to the mass ratio, adding 1.5-2.5 parts of glycerin and stirring, then adding 0.05-0.5 parts of the traditional Chinese medicine composition and stirring, and then adding 0.1-1 parts of essential oil and stirring to obtain a mixture. The resulting mixture is loaded with a polyvinyl alcohol film as the wall material to obtain the aroma-enhancing beads containing the traditional Chinese medicine composition.

6. A sanitary pad containing a traditional Chinese medicine composition with fragrant bursting beads, prepared by the method according to claim 5.