Acrylamide derivative and application

Abstract

The invention relates to an acrylamide derivative and application thereof. Specifically, the invention discloses a compound with a structure as shown in a formula (A) or a pharmaceutically acceptable salt thereof, and the compound in the formula (A) is shown in the specification for details. The compound has the advantage of high fatality rate on pests such as mosquitoes and flies.

Description

Technical Field

[0001] The present invention belongs to the field of pesticides and specifically relates to an acrylamide derivative and its application in the field of insecticides. Background Art

[0002] Pesticides are essential means of production for agricultural production. However, with the long-term use of pesticides, pests will develop different degrees of resistance, significantly reducing the efficacy of pesticides. The development of new pesticides with different mechanisms of action has always been a technical difficulty in pesticide creation. It is of great significance to conduct structural innovation to discover new pesticides with novel skeletons and excellent insecticidal activity. Summary of the invention

[0003] The primary purpose of the present invention is to provide an acrylamide derivative that can control a variety of agricultural and forestry pests or pests in other fields.

[0004] An acrylamide derivative, wherein the acrylamide derivative is a compound represented by formula (A) or a pharmaceutically acceptable salt thereof;

[0005]

[0006] In the formula, R1 is hydrogen, substituted or unsubstituted C 5-12 Aryl, substituted or unsubstituted C 2-12 Heteroaryl, C 1-10 Alkyl, C 1-10 Alkoxy, C 5-16 wherein the substituted refers to being substituted by one or more substituents selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, carboxyl, amino, nitro, sulfonic acid, C 1-6 Alkyl, halogenated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyl, halogenated C 3-6 Cycloalkyl, substituted or unsubstituted C 6-20 Aryl, substituted or unsubstituted C 2-20 Heteroaryl, C 1-6 wherein the substituted or unsubstituted substituent is selected from halogen, cyano, hydroxyl, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyl, phenyl, halogenated phenyl, benzyl;

[0007] R2 is hydrogen, C 1-15 Alkyl or absent;

[0008] R3 is hydrogen, substituted or unsubstituted C 6-20 Aryl, substituted or unsubstituted C 2-20 wherein the substituted refers to being substituted by one or more substituents selected from the group consisting of halogen, cyano, nitro, hydroxyl, amino, C 1-6 Alkyl, halogenated C 1-6 Alkyl, C 1-6 Alkoxy, carboxyl;

[0009] R4 is hydrogen, C 1-15 Alkyl, cyano, C 1-15 Alkoxy;

[0010] Preferably, in the formula (A), R4 is hydrogen or C 1-6 alkyl.

[0011] Preferably, in the formula (A), R3 is hydrogen, substituted or unsubstituted C 5-10 Aryl, substituted or unsubstituted C 2-8 wherein the substituted refers to being substituted by one or more substituents selected from the group consisting of halogen, cyano, nitro, hydroxyl, amino, C 1-6 Alkyl, halogenated C 1-6 Alkyl, C 1-6 Alkoxy, carboxyl.

[0012] Preferably, in the formula (A), R2 is hydrogen or C 1-6 alkyl.

[0013] Preferably, in the formula (A), R1 is hydrogen, substituted or unsubstituted C 5-10 Aryl, substituted or unsubstituted C 2-8 Heteroaryl, C 1-6 Alkyl, C 1-8 Alkoxy, C 5-12 wherein the substituted refers to being substituted by one or more substituents selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, carboxyl, amino, nitro, C 1-4 Alkyl, halogenated C 1-4 Alkyl, C 1-4 Alkoxy, halogenated C 1-4 Alkoxy, C 3-6 Cycloalkyl, halogenated C 3-6 Cycloalkyl, substituted or unsubstituted C 6-10 Aryl, substituted or unsubstituted C 2-8 Heteroaryl, C 1-4 wherein the substituted or unsubstituted substituent is selected from halogen, cyano, hydroxyl, amino, nitro, C 1-4 Alkyl, halogenated C 1-4 Alkyl, C1-4 Alkoxy, halogenated C 1-4 Alkoxy, C 3-6 Cycloalkyl, phenyl, halogenated phenyl, benzyl.

[0014] The compound of general formula (A) of the present invention is selected from the following compounds:

[0015]

[0016]

[0017] The synthesis route of the compound of the general formula (A) of the present invention, such as compounds A1 to A68, is shown below:

[0018]

[0019] wherein the substituents R1, R2, R3 and R4 are as defined above.

[0020] The base is one or more of sodium carbonate, sodium bicarbonate, potassium carbonate, cesium carbonate, potassium phosphate, sodium acetate, potassium acetate, triethylamine, isopropylamine and pyridine.

[0021] The reaction temperature is 25°C at room temperature and 0°C at an ice bath.

[0022] The reaction solvent is one of N,N-dimethylformamide, N,N-dimethylacetamide, acetonitrile, pyridine, tetrahydrofuran, 1,4-dioxane, acetone, dichloromethane, 1,2-dichloroethane, or a mixed solvent of two or more thereof.

[0023] The reaction time of the first step reaction is 10 minutes to 6 hours, and the reaction time of the second step reaction is 1 hour to 12 hours.

[0024] The synthesis steps of the specific embodiment are as follows:

[0025] Step 1: Add 100 mL of the above solvent to a 250 mL four-necked flask with mechanical stirring, add 12 mmol of demethyltropine hydrochloride, start stirring, and then add 15 mmol of the above base. After 30 minutes, slowly drop 10 mmol of the above acid chloride, react at room temperature for 1 hour, add 20 mL of water after the reaction is completed and continue stirring for 30 minutes, then stop stirring and let stand for 15 minutes, transfer to a 250 mL separatory funnel, separate the organic phase and remove the solvent by rotary evaporation at 25 ° C, the resulting residue is dissolved in dichloromethane, and separated and purified by column chromatography (petroleum ether: ethyl acetate) to obtain an intermediate.

[0026] Step 2: The intermediate obtained in the previous step was placed in a 250mL four-necked flask with mechanical stirring and 100mL of the above solvent was added, and then 20mmol of the above base was added, and the temperature was cooled to below 5°C in an ice bath, and 12mmol of the above acyl chloride was slowly added dropwise. After the addition was completed, the ice bath was removed and the reaction was carried out at room temperature. After the reaction was completed, 20mL of water was added and stirred for 15 minutes to quench the reaction, and then the mixture was transferred to a 250mL separating funnel, and the mixture was allowed to stand for 30 minutes to separate. The organic phase was taken and the solvent was removed by rotary evaporation at 25°C. The residue was dissolved in dichloromethane and separated and purified by column chromatography (petroleum ether: ethyl acetate) to obtain the target product.

[0027] A pesticide composition comprises (a) the acrylamide derivative or a pesticide-acceptable salt thereof; and (b) a pesticide-acceptable carrier.

[0028] The acrylamide derivative or its pesticide acceptable salt or the pesticide composition is used for controlling and eliminating agricultural and forestry pests, sanitary pests and pests endangering animal health.

[0029] The compound of general formula (A) shows an anti-pest effect on pests in the field of agricultural technology. Therefore, another technical scheme of the present invention relates to the use of the compound of general formula (A) or its pesticide-acceptable salt as an insecticide, that is, the use of the compound of general formula (A) or its pesticide-acceptable salt for preparing pest control in agriculture or other fields.

[0030] The compounds of the present invention can be used to control and eliminate a wide range of agricultural and forestry pests, sanitary pests, and pests that endanger animal health. In this specification, "pesticide" is a general term for all the pests mentioned above. Examples of pests include, but are not limited to, insects of the order Lepidoptera: for example, Plutella xylostella, Spodoptera frugiperda, S. exigua, S. litura, Lymantria dispar, Malacoscma neustria testacea, Diaphania perspectalis, Clania variegata, Cnidocampaflauescens, Dendrolimus punctatus, Orgyia antiqua, Paranthrene tabaniformis, Chilo suppressalis, Ostrinianubilalis, Ephestia cautella, Adoxophyes orana, Laspyresia splendana), Agrotis fucosa, Galleriamellonella, Phyllocnistis citrella, Mythimna separata, etc.Insects of the order Coleoptera: for example, Sitophilus zeamais, Tribolium castaneum, Henosepilachna vigintioctcmaculata, H. sparsa, Agriotes fusciollis, Ancmala cupripes, Popillia quadriguttata, Monolepta hieroglyphica, Monochamus alternatus, Echinocnemus squameus, Basiprionotabisignata, Anoplophora chinensis, Apriponagermari, Soclytus schevy, or Agriotes fusciollis. fuscicollis, etc.; Hemiptera: for example, Stephanitis nashi, Nezara viridla, Poecilocoris latus, Cletus punctiger, Dimorphopterus japonicus, Dysdercus cingulatus, etc.; Homoptera: for example, Nephotettix cincticeps, Unaspis yanonensis, Myzus persicae, Aphis gossydii, Bemisia tabaci, Laodelphax striatellus, Nilaparvata lugens, etc. lugens), white-backed planthopper (Sogatellafurcifera), etc.; Orthoptera insects: for example, African mole cricket (Gryllotalpa africana), Asian migratory locust (Locus migratoria), etc.; Hymenoptera insects: for example, red fire ant (Solenopsisinvicta), tobacco flat-horned wood wasp (Tremex fuscicornis), etc.;Insects of the order Blattella: for example, German cockroach (Blattellagermanica), American cockroach (Periplaneta american), house termite (Copotermes formosamus), etc.; Insects of the order Diptera: for example, housefly (Musca dcmestica), Aedes aegypti (Aedes aegypti), species fly (Delia platura), Culex fatigans, Anopheles sinensis, etc.; Plant parasitic nematodes: for example, root-knot nematodes, root-rot nematodes, rice stem tip nematodes, pine wood nematodes, etc. Pests that endanger animal health include Boophilus microplus, Haemaphysalis longicornis, Hyalcmma anatolicum, Hypoderma bovis, Fasciola hepatica, Moniezia blanchard, Trypanoscma enansi, Babesia bigemina, etc.;

[0031] An insecticide composition comprises an active component and an agriculturally acceptable carrier, wherein the active component comprises one or more acrylamide derivatives of general formula (A) or agriculturally acceptable salts thereof; preferably, the weight percentage of the active component in the composition is 0.01-99.99%.

[0032] The composition as defined above is prepared by mixing the compound of general formula (A) with a carrier. The active ingredient in such a composition may comprise a single compound of the invention or a mixture of several compounds.

[0033] The above composition can be applied in the form of a preparation. The compound of general formula (A) is dissolved or dispersed in a carrier as an active ingredient or formulated into a preparation so that it is easier to disperse when used as an insecticide; for example, these chemical preparations can be made into powders, wettable powders, emulsifiable concentrates, concentrated emulsions and microemulsions, suspoemulsions, granules, oils and ultra-low volume sprays, smoke-type, slow-release agents and other pesticide formulations. In these compositions, at least one liquid or solid carrier is added, and when necessary, a suitable surfactant can be added.

[0034] The carrier in the composition of the present invention is a substance that satisfies the following conditions: it is convenient to apply to the site to be treated, which may be a plant, seed or soil, after being formulated with the active ingredient; or it is convenient to store, transport or handle. The carrier may be solid or liquid, including a substance that is usually gaseous but has been compressed into a liquid, and any carrier commonly used in the formulation of insecticidal compositions can be used.

[0035] The agricultural composition can be used as an insecticide to kill or prevent agricultural and forestry pests, sanitary pests or pests that endanger animal health, kill or prevent plant pathogens and kill or prevent agricultural weeds.

[0036] The specific method of the above application is: applying the pesticide on the pests or on the medium where the pests grow.

[0037] For certain applications, such as in agriculture, one or more other types of insecticides, nematicides, miticides, plant growth regulators or fertilizers may be added to the insecticide composition of the present invention, thereby producing additional advantages and effects.

[0038] It should be understood that various changes and modifications can be made within the scope of the present invention as defined by the claims.

[0039] In addition, the present invention also provides the use of the acrylamide compound of the general formula (A) or its pesticide acceptable salt in the preparation of an insecticide, wherein the insecticide is used to kill pests, and the pests are housefly (Musca dcmestica), Aedes aegypti (Aedes aegypti), species fly (Delia platura), Culex fatigans, Anopheles sinensis, Blattella germanica, American cockroach (Periplaneta american), house termite (Copotermes formosamus), red fire ant (Solenopsis invicta), tobacco flat-horned wood wasp (Tremex fuscicornis) and the like.

[0040] Compared with the prior art, the present invention has the following advantages and beneficial effects:

[0041] The compound of general formula (A) shows good biological activity against pests in agriculture, forestry and other fields; the compound of general formula (A) can be used as an insecticide, especially the compound of general formula (A) has a good toxic effect on agricultural and sanitary pests such as housefly (Musca dcmestica), Aedes aegypti, Delia platura, Culex fatigans, Anopheles sinensis, Blattella germanica, Periplaneta american, Coptotermes formosamus, Solenopsis invicta, Tremex fuscicornis and the like. DETAILED DESCRIPTION

[0042] The present invention is further described in detail below in conjunction with the examples, but the embodiments of the present invention are not limited thereto. The raw materials involved in the present invention can be directly purchased from the market. For process parameters not particularly noted, conventional techniques can be used.

[0043] Synthesis Example 1: Preparation of Compound A1

[0044]

[0045] Step 1: Add 100 mL of dichloromethane and 12 mmol of demethyltropine hydrochloride to a 250 mL four-necked bottle with mechanical stirring, start stirring at room temperature, add 10 mmol of acryloyl chloride dropwise, and stir at room temperature for 1 hour. After the reaction is completed, add 20 mL of water and continue stirring for 30 minutes, then turn off the stirring and let it stand for 15 minutes before transferring to a 250 mL separatory funnel, transfer the lower layer (oil layer) to a 250 mL eggplant-shaped bottle, and evaporate the solvent under reduced pressure at 25°C to obtain a white waxy solid crude product. The obtained crude product was dissolved in 5 mL of dichloromethane and separated by column chromatography (the stationary phase was 300-400 mesh silica gel, and the mobile phase was petroleum ether: ethyl acetate = 60:40-50:50, v / v) to obtain a white waxy solid.

[0046] Step 2: Transfer the white waxy solid obtained by column chromatography into a 250 mL four-necked flask with mechanical stirring, add 100 mL of dichloromethane and start stirring, add 15 mmol of triethylamine, cool to <5°C in an ice bath, slowly drop 10 mmol of acetyl chloride, remove the ice bath after dropping, and stir at room temperature for 6 hours. After the reaction is completed, add 20 mL of water and stir for 30 minutes to quench the reaction. Then transfer the mixture to a 250 mL separatory funnel, let it stand for 30 minutes to separate the layers, put the lower layer (oil layer) into a 250 mL eggplant-shaped bottle, evaporate the solvent under reduced pressure at 25°C, dissolve the residue with 5 mL of dichloromethane, and perform column chromatography separation (the stationary phase is 300-400 mesh silica gel, and the mobile phase is petroleum ether: ethyl acetate = 80:20-70:30, v / v) to obtain a white solid as the target product.

[0047] Compound A1: white solid, 1 H NMR (404 MHz, Chloroform-d) δ6.42-6.31 (m, 1H), 5.81 (ddd, J = 17.0, 13.4, 2.4 Hz, 2H), 4.97 (p, J = 7.0 Hz,1H),4.03-3.91(m,2H),2.16-2.04(m,4H),2.03(s,3H),1.89-1.68(m,4H). 13 C NMR (101 MHz, Chloroform-d) δ167.45,152.53,143.50,128.69,128.61,127.32,126.69,126.62,115.61,50.22,25.54,22.09,20.59. 13 CNMR(101 MHz,Chloroform-d)δ171.06,166.69,128.67,127.31,67.88,53.56,53.56,35.88,35.88,29.44,29.44,21.28.

[0048] By taking the same steps as above and changing the corresponding raw materials, compounds A1-A68 can be synthesized, and all the raw materials are conventional commercially available pharmaceuticals.

[0049] The compounds of the present invention show good activity against various pests in the agricultural field. The results of the insecticidal activity test are shown in the following examples.

[0050] Example 1: Evaluation of the insecticidal activity of compounds against Plutella xylostella

[0051] The test insects are Plutella xylostella of the Lepidoptera order, and the sensitive strain is reared indoors. The third instar larvae of Plutella xylostella are used as the test objects, and the test method is the leaf dipping method.

[0052] Operation process: Accurately weigh each sample, add DMSO to prepare a 10g / L mother solution, and dilute it with a 0.5% Tween 80 aqueous solution. Use a 1.0cm diameter puncher to make a leaf disc from clean Chinese cabbage leaves, and immerse it in the drug solution. Take it out after 10 seconds, dry it naturally, and move it into a clean container. Inoculate the 3rd instar larvae of the diamondback moth with consistent growth into the container, and inoculate 10 test insects for each treatment, and raise them at a constant temperature of 28°C. Set up 3 repetitions, and the control group is treated with an aqueous solution containing an equal amount of 0.5% Tween 80-DMSO. Observe the test results after 96 hours, and calculate the mortality rate (%) according to the formula. Mortality rate (%) = number of dead insects / number of test insects × 100%.

[0053] The synthesized compound (A) was tested according to the above experimental steps.

[0054] When the concentration of the compound was 500 mg / L, the mortality rate of Plutella xylostella was greater than 90%.

[0055] When the compound concentration is 100 mg / L, the compounds with a mortality rate of more than 90% for diamondback moth are:

[0056] A1-A6, A9-A11, A16, A18, A22, A29, A37, A39-A42, A49-A51, A53, A55-A59, A61-A63, A68.

[0057] Example 2: Evaluation of the insecticidal activity of compounds against sanitary pests

[0058] Test insects: Culex pipiens, female adults that have not sucked blood on the 3rd to 5th day after emergence

[0059] Housefly, adult flies 3-4 days after emergence, half male and half female

[0060] German cockroach, 10-15 days old, half male and half female

[0061] Test method: Refer to GB / T 13917.2-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration Part 2: Aerosol method.

[0062] Mosquitoes and flies: Use a cylinder device. The specific method is to put the test insects (30 houseflies, or 30 mosquitoes) into the cylinder. After the test insects resume normal activities, place the aerosol cylinder to be tested horizontally, with the nozzle pointing vertically downward, aiming at the spray hole, spray the agent (1.0±0.1g), and immediately plug the round hole with a rubber stopper. After 1 minute, remove the pull plate, start timing immediately, and record the number of knocked-down test insects at regular intervals. After 20 minutes, move the knocked-down test insects to a clean insect cage, restore the feeding standard, feed them with 5% sugar water cotton balls, check the number of dead insects for 24 hours, and count the test insects that have not been knocked down as live insects. The test should be repeated three times or more. At the end of each test, the test device should be cleaned, and the mortality rate (%) should be calculated according to the formula mortality rate (%) = number of dead insects / number of test insects × 100%.

[0063] Cockroaches: Use a cylinder device without pulling the board. Place 20 German cockroaches in a cylinder with a circle of vaseline on the upper part of the inner wall and sealed with a 12-mesh iron screen. After the test insects resume normal activities, place the aerosol cylinder horizontally, aim the nozzle vertically downward at the spray hole, spray the agent (1.0±0.1g), immediately plug the round hole with a rubber plug, start timing, and record the number of knocked-down test insects at regular intervals. After 20 minutes, transfer all test insects to a clean container, resume standard feeding, feed with mixed feed blocks and soaked cotton balls, and check the number of dead insects in 72 hours. The test should be repeated three times or more. At the end of each test, the test device should be cleaned, and the mortality rate (%) should be calculated according to the formula mortality rate (%) = number of dead insects / number of test insects × 100%.

[0064] The synthesized compounds A1-A68 were tested according to the above experimental steps.

[0065] The compound test concentration was 50 mg / L.

[0066] The compounds with mosquito mortality greater than 90% are: A3-A5, A9-A14, A16, A19, A37, and A65.

[0067] The compounds with fly mortality greater than 90% are: A2-A11, A17-A24, A26, A29, A37, A39, A41-A49, A55, A57-A61, and A65.

[0068] The compounds with cockroach mortality greater than 90% are: A2, A17, A29, A37, A41, A44, A55, A57-A61, and A65.

[0069] The above embodiments are preferred implementation modes of the present invention, but the implementation modes of the present invention are not limited to the above embodiments. Any other changes, modifications, substitutions, combinations, and simplifications that do not deviate from the spirit and principles of the present invention should be equivalent replacement methods and are included in the protection scope of the present invention.

Claims

1. An acrylamide derivative, characterized in that: The acrylamide derivative is a compound represented by formula (A) or a pharmaceutically acceptable salt thereof; In the formula, R1 is hydrogen, substituted or unsubstituted C 5-12 Aryl, substituted or unsubstituted C 2-12 Heteroaryl, C 1-10 Alkyl, C 1-10 Alkoxy, C 5-16 wherein the substituted refers to being substituted by one or more substituents selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, carboxyl, amino, nitro, sulfonic acid, C 1-6 Alkyl, halogenated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyl, halogenated C 3-6 Cycloalkyl, substituted or unsubstituted C 6-20 Aryl, substituted or unsubstituted C 2-20 Heteroaryl, C 1-6 wherein the substituted or unsubstituted substituent is selected from halogen, cyano, hydroxyl, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 Alkyl, C 1-6 Alkoxy, halogenated C 1-6 Alkoxy, C 3-6 Cycloalkyl, phenyl, halogenated phenyl, benzyl; R2 is hydrogen, C 1-15 Alkyl or absent; R3 is hydrogen, substituted or unsubstituted C 6-20 Aryl, substituted or unsubstituted C 2-20 wherein the substituted refers to being substituted by one or more substituents selected from the group consisting of halogen, cyano, nitro, hydroxyl, amino, C 1-6 Alkyl, halogenated C 1-6 Alkyl, C 1-6 Alkoxy, carboxyl; R4 is hydrogen, C 1-15 Alkyl, cyano, C 1-15 Alkoxy.

2. The acrylamide derivative according to claim 1, characterized in that In the formula (A), R4 is hydrogen or C 1-6 alkyl.

3. The acrylamide derivative according to claim 1, characterized in that In the formula (A), R3 is hydrogen, substituted or unsubstituted C 5-10 Aryl, substituted or unsubstituted C 2-8 wherein the substituted refers to being substituted by one or more substituents selected from the group consisting of halogen, cyano, nitro, hydroxyl, amino, C 1-6 Alkyl, halogenated C 1-6 Alkyl, C 1-6 Alkoxy, carboxyl.

4. The acrylamide derivative according to claim 1, characterized in that In the formula (A), R2 is hydrogen or C 1-6 alkyl.

5. The acrylamide derivative according to claim 1, characterized in that In the formula (A), R1 is hydrogen, substituted or unsubstituted C 5-10 Aryl, substituted or unsubstituted C 2-8 Heteroaryl, C 1-6 Alkyl, C 1-8 Alkoxy, C 5-12 wherein the substituted refers to being substituted by one or more substituents selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, carboxyl, amino, nitro, C 1-4 Alkyl, halogenated C 1-4 Alkyl, C 1-4 Alkoxy, halogenated C 1-4 Alkoxy, C 3-6 Cycloalkyl, halogenated C 3-6 Cycloalkyl, substituted or unsubstituted C 6-10 Aryl, substituted or unsubstituted C 2-8 Heteroaryl, C 1-4 wherein the substituted or unsubstituted substituent is selected from halogen, cyano, hydroxyl, amino, nitro, C 1-4 Alkyl, halogenated C 1-4 Alkyl, C 1-4 Alkoxy, halogenated C 1-4 Alkoxy, C 3-6 Cycloalkyl, phenyl, halogenated phenyl, benzyl.

6. The acrylamide compound according to claim 1, characterized in that: The compound of general formula (A) is selected from the following compounds:

7. A pesticide composition, characterized in that: The invention comprises (a) the acrylamide derivative according to any one of claims 1 to 6 or a pesticide-acceptable salt thereof; and (b) a pesticide-acceptable carrier.

8. Use of the acrylamide derivative or the pesticide acceptable salt thereof according to any one of claims 1 to 6 or the pesticide composition according to claim 7 for controlling and eliminating agricultural and forestry pests, sanitary pests and pests endangering animal health.

9. An insecticidal composition comprising an active ingredient and an agriculturally acceptable carrier, characterized in that: The active component contains one or more acrylamide derivatives according to the general formula (A) in claim 1 or agriculturally acceptable salts thereof; preferably, the weight percentage of the active component in the composition is 0.01-99.99%.

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