Full-automatic treatment equipment for biological samples

Abstract

The invention relates to the technical field of biomedical engineering, and provides full-automatic biological sample treatment equipment which comprises a frame body, an oscillation mechanism is installed at the bottom of the inner wall of the frame body and comprises a base, a Z-shaped supporting rod is rotationally connected to the top of the base, a shaking plate is rotationally connected to the top of the Z-shaped supporting rod, and a rotating shaft is rotationally connected to the top of the base; a connecting rod is fixedly connected to the top of the rotating shaft, a shaft rod penetrates through the top of the connecting rod, and one end of the shaft rod is fixedly connected with the bottom of the shaking plate; through cooperation of the oscillation mechanism, the centrifugal assembly, the cap assembling and disassembling assembly and the liquid taking mechanism, the whole process of biological sample treatment can be completed on the equipment, tedious operation steps are avoided, the labor intensity of operators is reduced, the situation that errors are generated due to manual operation, and the later detection result is affected is prevented, and the detection efficiency is improved. In addition, the technical difficulty of biological sample treatment is reduced while the biological sample treatment efficiency is improved.

Description

Technical Field

[0001] The invention relates to the technical field of biomedical engineering, in particular to a fully automatic biological sample processing device. Background Art

[0002] As people pay more and more attention to their health, the demand for such testing and screening is also increasing. With the development of genetic testing technology, more and more related diseases and virus screenings must rely on blood screening. This means that such testing needs to improve efficiency and accuracy. In recent years, the field of medical equipment engineering has rapidly combined intelligence and automation with the field of conventional medical testing. In such testing operations that require a large number of test tubes and reagent samples, the demand for equipment for rapid batch operation of samples is also increasing.

[0003] The biological sample processing process is as follows: the first step is to take the sample, the second step is vortexing, the third step is centrifugation, and the fourth step is to take the supernatant.

[0004] Some existing biological sample processing equipment often has relatively single functions and cannot perform the full process steps of biological sample processing. It usually requires the collaboration of multiple devices to complete. It is necessary to manually add stabilizers to the samples in the test tubes, and then manually transfer the test tubes containing the samples to a vortex oscillation instrument for thorough mixing. The test tubes are then transferred to a centrifuge to separate the samples in the test tubes. Finally, the supernatant separated in the test tubes is manually extracted. The above-mentioned operation steps are relatively cumbersome and inefficient. Manual operation is prone to errors, which affects the subsequent test results.

[0005] In summary, the inventor provides a fully automatic biological sample processing device. Summary of the invention

[0006] The present invention provides a fully automatic biological sample processing device, which solves the problems in the background technology that the existing operation steps are complicated and the efficiency is low, and manual operation is prone to errors, which affects the later detection results, etc. through the cooperation of an oscillating mechanism, a centrifugal component, a cap assembly and disassembly component and a liquid collection mechanism.

[0007] The technical solution of the present invention is as follows:

[0008] A biological sample fully automatic processing device comprises: a frame, an oscillating mechanism is installed at the bottom of the inner wall of the frame, the oscillating mechanism comprises a base, a Z-shaped support rod is rotatably connected to the top of the base, a shaking plate is rotatably connected to the top of the Z-shaped support rod, a rotating shaft is rotatably connected to the top of the base, a connecting rod is fixedly connected to the top of the rotating shaft, a shaft rod is provided through the top of the connecting rod, one end of the shaft rod is fixedly connected to the bottom of the shaking plate, and the shaft rod is rotatably connected to the connecting rod, a first bevel gear is fixedly connected to the rotating shaft, a first motor is fixedly connected to the top of the base at a position close to the first bevel gear, a second bevel gear is fixedly connected to the output end of the first motor, and the second bevel gear is meshed with the first bevel gear, a centrifugal assembly is arranged on the top of the shaking plate, an electric cylinder is fixedly connected to the top of the inner wall of the frame, a push plate is fixedly connected to the output end of the electric cylinder, a plurality of mounting plates are fixedly connected to the bottom of the push plate, a cap assembly and disassembly assembly is installed on the mounting plate, and the cap assembly and disassembly assembly is located directly above the centrifugal assembly, and a liquid taking mechanism is arranged on one side of the inner wall of the frame.

[0009] Furthermore, the centrifugal assembly includes a sleeve fixed on the top of the shaking plate, the top of the sleeve is rotatably connected to a turntable through a bearing, a second motor is fixedly installed on the inner side of the sleeve at the top of the shaking plate, the output end of the second motor is fixedly connected to the bottom of the turntable, and a plurality of rotation tilting mechanisms are installed on the top of the turntable.

[0010] Furthermore, the rotation and tilting mechanism includes a mounting component and a limit plate, the bottom of the mounting component is fixedly connected to the top of the turntable, the bottom of the limit plate is fixed to the edge of the top of the turntable, a counterweight block is arranged between the side wall of the limit plate and the side wall of the mounting component, a pair of sliding rods are penetrated through the side wall of the counterweight block, the counterweight block is slidably connected to the sliding rods, the two ends of the sliding rods are respectively fixedly connected to the side wall of the limit plate and the side wall of the mounting component, a spring is respectively sleeved on the outside of the sliding rod, and the two ends of the spring are respectively fixedly connected to the side wall of the counterweight block and the side wall of the limit plate.

[0011] Furthermore, the rotation and tilting mechanism also includes a pipe loader, the bottom end of the pipe loader is rotatably connected to the top of the counterweight block, the side wall of the mounting component is provided with a first slide groove, and limiting grooves are provided on both sides of the inner wall of the first slide groove. A first slider is slidably installed in the first slide groove, and limiting blocks are fixedly connected on both sides of the first slider, the limiting blocks extend into the limiting grooves, and one side of the first slider is fixedly connected to a rod body, and the other end of the rod body is rotatably connected to the side wall of the pipe loader.

[0012] Furthermore, a socket is provided at the top of the tube loader, a cushion is provided on the inner wall of the socket, a test tube 1 is inserted into the socket, and a cap is threadedly connected to the top of the test tube 1.

[0013] Further, the cap mounting and dismounting assembly includes a first through groove formed in the mounting plate. Second sliding grooves are formed on both sides of the inner wall of the first through groove. A second slider is slidably mounted in the first through groove through the second sliding grooves. One side of the second slider extends out of the first through groove and is fixedly connected to a capping machine. The other side of the second slider is fixedly connected to a fixing plate. A first electric telescopic rod is fixedly connected to the side of the mounting plate away from the capping machine. The output end of the first electric telescopic rod is fixedly connected to the side wall of the fixing plate.

[0014] Further, a second through groove is formed at the bottom end of the side wall of the mounting plate. Third sliding grooves are formed at the top and bottom of the inner wall of the second through groove. A pair of third sliders are mounted in the second through groove through the third sliding grooves. A clamping jaw is fixedly connected to one side of each of the pair of third sliders. The clamping jaws are located below the capping machine. The other side of the third slider away from the clamping jaw is rotatably connected to a push rod through a pin. The other end of the push rod is rotatably connected to a first push block through a pin. A second electric telescopic rod is arranged on one side of the first push block. The output end of the second electric telescopic rod is fixedly connected to the top of the first push block. The second electric telescopic rod is fixedly connected to the side wall of the mounting plate. The output end of the second electric telescopic rod is fixedly connected to the top of the first push block.

[0015] Further, the liquid taking mechanism includes a first mounting platform and a second mounting platform fixed to one side of the inner wall of the frame. A third through groove is formed at the bottom of the inner wall of the first mounting platform. Fourth sliding grooves are formed on both sides of the inner wall of the third through groove. An L-shaped moving block is slidably mounted in the third through groove through the fourth sliding grooves. A first lead screw penetrates through the side wall of the L-shaped moving block and is threadedly connected to the L-shaped moving block. One end of the first lead screw is rotatably connected to one side of the inner wall of the first mounting platform. The other end of the first lead screw is connected to a third motor. The bottom of the third motor is fixedly connected to the bottom of the inner wall of the first mounting platform.

[0016] Further, a U-shaped member is fixedly connected to one side of the L-shaped moving block. A partition is fixedly connected to the inner wall of the U-shaped member. A translation block is arranged inside the U-shaped member. A second lead screw and a limiting rod respectively penetrate through the side wall of the translation block. The translation block is threadedly connected to the second lead screw. The translation block is slidably connected to the limiting rod. One end of the second lead screw is rotatably connected to one side of the inner wall of the U-shaped member. The other end of the second lead screw penetrates through the partition and is connected to a fourth motor, and the second lead screw is rotatably connected to the partition. One side of the fourth motor is fixedly connected to the inner wall of the U-shaped member. Both ends of the limiting rod are respectively fixedly connected to one side of the inner wall of the U-shaped member and the side wall of the partition. A liquid adding device is mounted on the side wall of the translation block. A third electric telescopic rod is fixedly connected to the position on the side wall of the translation block away from the liquid adding device. The output end of the third electric telescopic rod is fixedly connected to a second push block. A liquid transfer pipette is mounted at one end of the second push block.

[0017] Furthermore, a plurality of sockets one, a plurality of sockets two and a waste storage cavity are provided on the top of the second installation platform, a plurality of the sockets one are each inserted with a test tube two, and a plurality of the sockets two are each inserted with a plurality of pipette nozzles.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] 1. The present invention cooperates with the oscillating mechanism, the centrifugal assembly, the cap assembly and disassembly assembly and the liquid collection mechanism, so that the whole process of biological sample processing can be completed on the device, avoiding cumbersome operation steps, reducing the labor intensity of operators, preventing errors caused by manual operation and affecting the subsequent detection results, and while improving the efficiency of biological sample processing, reducing the technical difficulty of biological sample processing.

[0020] 2. The present invention uses a rotation tilting mechanism to tilt test tube one when the turntable rotates at high speed, so that test tube one is tilted at a certain angle to the direction of centrifugal force, changing the centrifugal force distribution during sample centrifugation, thereby improving separation accuracy and efficiency, and allowing impurities in the sample to settle to the bottom of test tube one, facilitating the subsequent extraction of supernatant.

[0021] 3. The present invention can disassemble the cap of test tube one through the cap assembly and disassembly assembly, which is convenient for the liquid collection mechanism to add stabilizer to the biological sample in test tube one and extract the supernatant in the later stage. When the sample is vortexed and centrifuged, the cap can be connected to test tube one to ensure the sealing of test tube one and avoid spilling of the sample. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is an overall three-dimensional schematic diagram of the present invention;

[0023] Figure 2 It is a three-dimensional schematic diagram of the oscillation mechanism of the present invention;

[0024] Figure 3 It is a plan view of the oscillating mechanism of the present invention;

[0025] Figure 4 It is a three-dimensional schematic diagram of the centrifugal assembly of the present invention;

[0026] Figure 5 It is a three-dimensional schematic diagram of the rotating and tilting mechanism of the present invention;

[0027] Figure 6 It is an exploded perspective schematic diagram of the components of the rotation and tilt mechanism of the present invention;

[0028] Figure 7 It is a three-dimensional schematic diagram of the cap assembly and disassembly assembly of the present invention;

[0029] Figure 8 It is an exploded perspective schematic diagram of the cap assembly and disassembly components of the present invention;

[0030] Fig. 9 This is a three-dimensional schematic diagram of the liquid extraction mechanism of the present invention.

[0031] In the figure:

[0032] 1. Frame; 2. Oscillation mechanism; 21. Base; 22. Z-shaped support rod; 23. Shaking plate; 24. Rotating shaft; 25. Connecting rod; 26. Shaft rod; 27. First bevel gear; 28. First motor; 29. Second bevel gear; 3. Centrifugal component; 31. Sleeve; 32. Turntable; 33. Second motor; 34. Follow-rotation tilting mechanism; 341. Mounting member; 342. Limiting plate; 343. Counterweight; 344. Slide rod; 345. Spring; 346. Tube installer; 347. First chute; 348. Limiting groove; 349. First slider; 3410. Limiting block; 3411. Rod body; 3412. Insertion hole; 3413. Soft pad; 3414. First test tube; 3415. Cap; 4. Electric cylinder; 41. Push plate; 42. Mounting plate; 5. Cap installation and disassembly component; 51. First through groove; 52. Second chute; 53. Second slider; 54. Capping machine; 55. Fixed plate; 56. First electric telescopic rod; 57. Second through groove; 58. Third chute; 59. Third slider; 510. Claw; 511. Push rod; 512. First push block; 513. Second electric telescopic rod; 6. Liquid extraction mechanism; 61. First installation platform; 62. Second installation platform; 63. Third through groove; 64. Fourth chute; 65. L-shaped moving block; 66. First lead screw; 67. Third motor; 68. C-shaped member; 69. Partition; 610. Translation block; 611. Second lead screw; 612. Limiting rod; 613. Fourth motor; 614. Liquid adding device; 615. Third electric telescopic rod; 616. Second push block; 617. Pipette; 618. First socket; 619. Second socket; 620. Second test tube; 621. Liquid suction nozzle; 622. Waste storage cavity. Specific embodiments

[0033] The following further describes in detail the embodiments of the present invention in conjunction with the accompanying drawings and examples. The following examples are used to illustrate the present invention, but cannot be used to limit the scope of the present invention.

[0034] Such as Figure 1As shown in Figure 9, the present invention provides a fully automatic biological sample processing device, including: a frame 1, an oscillation mechanism 2 is installed at the bottom of the inner wall of the frame 1, the oscillation mechanism 2 includes a base 21, the top of the base 21 is rotatably connected to a Z-shaped support rod 22, the top of the Z-shaped support rod 22 is rotatably connected to a shaking plate 23, the top of the base 21 is rotatably connected to a rotating shaft 24, the top of the rotating shaft 24 is fixedly connected to a connecting rod 25, the top of the connecting rod 25 is penetrated by a shaft rod 26, one end of the shaft rod 26 is fixedly connected to the bottom of the shaking plate 23, and the shaft rod 26 is rotatably connected to the connecting rod 25, and the rotating shaft 24 is fixedly connected to a first bevel gear. 27, a first motor 28 is fixedly connected to the top of the base 21 at a position close to the first bevel gear 27, a second bevel gear 29 is fixedly connected to the output end of the first motor 28, the second bevel gear 29 is meshed with the first bevel gear 27, a centrifugal assembly 3 is arranged on the top of the shaking plate 23, an electric cylinder 4 is fixedly connected to the top of the inner wall of the frame 1, a push plate 41 is fixedly connected to the output end of the electric cylinder 4, a plurality of mounting plates 42 are fixedly connected to the bottom of the push plate 41, a cap assembly and disassembly assembly 5 is installed on the mounting plate 42, the cap assembly and disassembly assembly 5 is located directly above the centrifugal assembly 3, and a liquid taking mechanism 6 is arranged on one side of the inner wall of the frame 1.

[0035] Among them, the centrifugal assembly 3 includes a sleeve 31 fixed on the top of the shaking plate 23, and the top of the sleeve 31 is rotatably connected to a turntable 32 through a bearing. A second motor 33 is arranged inside the sleeve 31, and the bottom of the second motor 33 is fixedly connected to the top of the shaking plate 23, and the output end of the second motor 33 is fixedly connected to the bottom of the turntable 32, and a plurality of rotating tilting mechanisms 34 are installed on the top of the turntable 32.

[0036] Among them, the rotation and tilting mechanism 34 includes a mounting component 341 and a limit plate 342, the bottom of the mounting component 341 is fixedly connected to the top of the turntable 32, the bottom of the limit plate 342 is fixed to the edge of the top of the turntable 32, a counterweight block 343 is arranged between the side wall of the limit plate 342 and the side wall of the mounting component 341, a pair of sliding rods 344 are penetrated through the side wall of the counterweight block 343, the counterweight block 343 is slidably connected to the sliding rod 344, the two ends of the sliding rod 344 are respectively fixedly connected to the side wall of the limit plate 342 and the side wall of the mounting component 341, a spring 345 is sleeved on the outside of the sliding rod 344, and the two ends of the spring 345 are respectively fixedly connected to the side wall of the counterweight block 343 and the side wall of the limit plate 342.

[0037] Among them, the rotation and tilting mechanism 34 also includes a tube loader 346, the bottom end of the tube loader 346 is rotatably connected to the top of the counterweight block 343, the side wall of the mounting component 341 is provided with a first slide groove 347, and the inner walls of the first slide groove 347 are provided with limiting grooves 348 on both sides, and a first slider 349 is slidably installed in the first slide groove 347, and both sides of the first slider 349 are fixedly connected to limiting blocks 3410, and the limiting blocks 3410 extend into the limiting groove 348, and one side of the first slider 349 is fixedly connected to a rod body 3411, and the other end of the rod body 3411 is rotatably connected to the side wall of the tube loader 346.

[0038] The top of the tube loader 346 is provided with a socket 3412, the inner wall of the socket 3412 is provided with a cushion 3413, a test tube 1 3414 is inserted into the socket 3412, and a cap 3415 is threadedly connected to the top of the test tube 1 3414.

[0039] Among them, the cap assembly and disassembly component 5 includes a first through slot 51 opened on the mounting plate 42, second slide slots 52 are opened on both sides of the inner wall of the first through slot 51, a second slider 53 is slidably installed in the first through slot 51 through the second slide slot 52, one side of the second slider 53 extends out of the first through slot 51 and is fixedly connected to a capping machine 54, and the other side of the second slider 53 is fixedly connected to a fixing plate 55, and a first electric telescopic rod 56 is fixedly connected to the side of the mounting plate 42 away from the capping machine 54, and the output end of the first electric telescopic rod 56 is fixedly connected to the side wall of the fixing plate 55.

[0040] Among them, a second through slot 57 is provided at the bottom end of the side wall of the mounting plate 42, and a third sliding slot 58 is provided at the top and bottom of the inner wall of the second through slot 57. A pair of third sliding blocks 59 are installed in the second through slot 57 through the third sliding slot 58, and one side of the pair of third sliding blocks 59 is fixedly connected with a clamping jaw 510, and the clamping jaw 510 is located directly below the capping machine 54. The side of the third sliding block 59 away from the clamping jaw 510 is rotatably connected with a push rod 511 through an axle pin, and the other end of the push rod 511 is rotatably connected with a push block 512 through an axle pin. A second electric telescopic rod 513 is provided on one side of the push block 512, and the second electric telescopic rod 513 is fixedly connected to the side wall of the mounting plate 42, and the second electric telescopic rod 513 is located below the first electric telescopic rod 56, and the output end of the second electric telescopic rod 513 is fixedly connected to the top of the push block 512.

[0041] Among them, the liquid extraction mechanism 6 includes a first installation platform 61 and a second installation platform 62 fixed on one side of the inner wall of the frame body 1. A third through groove 63 is opened at the bottom of the inner wall of the first installation platform 61. Fourth sliding grooves 64 are opened on both sides of the inner wall of the third through groove 63. An L-shaped moving block 65 is slidably installed in the third through groove 63 through the fourth sliding grooves 64. A first lead screw 66 penetrates through the side wall of the L-shaped moving block 65 and is threadedly connected to the first lead screw 66. One end of the first lead screw 66 is rotatably connected to one side of the inner wall of the first installation platform 61. The other end of the first lead screw 66 is connected to a third motor 67. The bottom of the third motor 67 is fixedly connected to the bottom of the inner wall of the first installation platform 61.

[0042] Among them, a C-shaped member 68 is fixedly connected to one side of the L-shaped moving block 65. A partition 69 is fixedly connected to the inner wall of the C-shaped member 68. A translation block 610 is arranged inside the C-shaped member 68. A second lead screw 611 and a limiting rod 612 penetrate through the side wall of the translation block 610 respectively. The translation block 610 is threadedly connected to the second lead screw 611. The translation block 610 is slidably connected to the limiting rod 612. One end of the second lead screw 611 is rotatably connected to one side of the inner wall of the C-shaped member 68. The other end of the second lead screw 611 penetrates through the partition 69 and is connected to a fourth motor 613. And the second lead screw 611 is rotatably connected to the partition 69. One side of the fourth motor 613 is fixedly connected to the inner wall of the C-shaped member 68. Both ends of the limiting rod 612 are fixedly connected to one side of the inner wall of the C-shaped member 68 and the side wall of the partition 69 respectively. A liquid adding device 614 is installed on the side wall of the translation block 610. A third electric telescopic rod 615 is fixedly connected to the position on the side wall of the translation block 610 far from the liquid adding device 614. The output end of the third electric telescopic rod 615 is fixedly connected to a second pushing block 616. A pipette 617 is installed at one end of the second pushing block 616.

[0043] Among them, a number of first sockets 618, a number of second sockets 619 and a waste storage cavity 622 are opened at the top of the second installation platform 62. A second test tube 620 is inserted into each of the number of first sockets 618. A number of pipette tips 621 are inserted into each of the number of second sockets 619.

[0044] Embodiment:

[0045] Such as Figure 1As shown in Figure 9, in this embodiment, first, the staff inserts the test tube 1 3414 containing the biological sample into the insertion hole 3412 of the tube loader 346 of the rotating and tilting mechanism 34 in sequence, and then starts the electric cylinder 4 to push the push plate 41, driving the cap assembly 5 to move toward the rotating and tilting mechanism 34, until each test tube 1 3414 in the rotating and tilting mechanism 34 enters between the two clamping claws 510 of the cap assembly 5, and starts the second electric telescopic rod 513 to pull the push block 1 512 upward. During the upward movement of the push block 1 512, a pair of third slide blocks 59 are pulled by a pair of push rods 511 to move in the second through groove 57 along the third slide groove 58 toward the center of the second through groove 57, thereby driving the clamping claw 510 fixed on one side of the third slide block 59 to clamp the test tube 1 3414 to fix it, and then starts the capping machine 54. The cap 3415 is clamped and rotated. At the same time, the first electric telescopic rod 56 is started to push the fixed plate 55 to drive the second slide block 53 to move upward in the first through groove 51 along the second slide groove 52, thereby driving the capping machine 54 fixedly connected to one side of the second slide block 53 to move upward synchronously, so that the cap 3415 threadedly connected to the test tube 1 3414 is gradually separated from the test tube 1 3414 during the rotation process. Finally, the second electric telescopic rod 513 is started to push the push block 1 512, and a pair of third slide blocks 59 are moved to the two ends of the second through groove 57 respectively through a pair of push rods 511, so that the clamping claw 510 releases the clamping of the test tube 1 3414 and resets. The electric cylinder 4 is started again to pull the push plate 41 to drive the cap assembly and disassembly assembly 5 away from the rotating and tilting mechanism 34, and the cap 3415 is reset. At this time, the test tube 1 3414 is in an open state.

[0046] Start the third motor 67 to rotate the first lead screw 66. The rotation of the first lead screw 66 drives the L-shaped moving block 65 to displace along the fourth chute 64 in the third through groove 63 towards the centrifugal assembly 3. The C-shaped member 68 fixedly connected to one side of the L-shaped moving block 65 is displaced synchronously. When the C-shaped member 68 is displaced, the C-shaped member 68 drives the translation block 610 connected to its interior through the second lead screw 611 and the limit rod 612 to move. The movement of the translation block 610 drives the liquid adding device 614 installed on one side to displace, so that the liquid adding device 614 is located above one of the rotating and tilting mechanisms 34 closest to the liquid taking mechanism 6. Start the fourth motor 613 to rotate the second lead screw 611, driving the translation block 610 to translate along the second lead screw 611, thereby driving the liquid adding device 614 to move, and further adjusting the position of the liquid adding device 614 so that the liquid adding device 614 is located above the opening of the first test tube 3414, so as to add the stabilizer into the first test tube 3414. Start the second motor 33 of the centrifugal assembly 3 to rotate the turntable 32 intermittently multiple times, and the rotation angle is 360° / X (X is the number of the centrifugal assemblies 3), so that multiple first test tubes 3414 are sequentially displaced below the liquid adding device 614, and further complete the addition of the stabilizer in multiple first test tubes 3414. After the samples in all the first test tubes 3414 are added, the liquid adding device 614 resets to the initial position.

[0047] Then start the electric cylinder 4 again, so that the cap installing and removing assembly 5 installs the cap 3415 on the top of the first test tube 3414 to seal the first test tube 3414, and then the cap installing and removing assembly 5 resets again.

[0048] Subsequently, start the first motor 28 to rotate the second bevel gear 29. The rotation of the second bevel gear 29 drives the first bevel gear 27 meshing with it to rotate. The rotation of the first bevel gear 27 drives the rotating shaft 24 fixedly connected to it to rotate. The rotation of the rotating shaft 24 makes the connecting rod 25 fixedly connected to the top of the rotating shaft 24 rotate. The connecting rod 25 drives the shaft rod 26 to rotate around the rotating shaft 24 as the axis. Since the shaking plate 23 is connected to the base 21 through multiple Z-shaped support rods 22, and both the shaking plate 23 and the base 21 are rotatably connected to the Z-shaped support rods 22, the Z-shaped support rods 22 have a supporting effect on the shaking plate 23 and a limiting effect on the shaking plate 23. When the shaft rod 26 rotates around the rotating shaft 24 as the axis, the shaking plate 23 makes a circular swing with the radius from the axis of the shaft rod 26 to the axis of the rotating shaft 24.

[0049] It should be noted that there are a total of 4 Z-shaped support rods 22, and they are distributed at the four corners of the shaking plate 23. The horizontal distance between the top center point of the Z-shaped support rod 22 and the bottom center point of the Z-shaped support rod 22 is equal to the horizontal distance from the axis of the shaft 26 to the axis of the rotating shaft 24. Therefore, when the shaking plate 23 produces a circular swing with the axis of the shaft 26 to the axis of the rotating shaft 24 as the radius, the Z-shaped support rod 22 rotates with its bottom center point as the axis, thereby keeping the Z-shaped support rod 22 always supported when the shaking plate 23 swings, and improving stability.

[0050] When the shaking plate 23 swings in a circle, it will drive the rotating tilting mechanism 34 of the centrifugal assembly 3 to move synchronously, thereby causing the test tube 3414 in the socket 3412 on the tube loader 346 to move synchronously. Since the shaking plate 23 is in a circle, the sample solution in the test tube 3414 is vibrated, so that the biological sample and the stabilizer can be quickly and evenly merged, thereby improving the accuracy and repeatability of the detection.

[0051] After the sample in the test tube 1 3414 is shaken, the second motor 33 of the centrifugal assembly 3 is started to rotate the turntable 32 at a high speed, so that the test tube 1 3414 rotates with the center of the turntable 32 as the axis. Under the action of centrifugal force, the counterweight block 343 of the rotating and tilting mechanism 34 moves along the slide rod 344 toward the edge of the turntable 32, and the spring 345 between the side wall of the counterweight block 343 and the side wall of the limit plate 342 is compressed. Since the top of the counterweight block 343 is rotatably connected to the bottom of the tube loader 346, and the side wall of the tube loader 346 is rotatably connected to one end of the rod body 3411, when the counterweight block 343 moves toward the edge of the turntable 32, the tube loader 346 will tilt, and at the same time, the counterweight block 343 moves synchronously. Under the drag of the tube loader 346, the first slider 349 fixedly connected to the other end of the rod body 3411 slides in the first slide groove 347, and the tilt of the tube loader 346 drives the test tube 1 3414 to tilt.

[0052] After the biological sample in the test tube 1 3414 is separated, the second motor 33 is turned off to slowly stop the turntable 32. During the process, the centrifugal force on the counterweight 343 gradually decreases, and the pressure on the spring 345 also gradually decreases. The spring 345 slowly extends to push the counterweight 343 to return to its original position. When the counterweight 343 is returned to its original position, the tube loader 346 drives the test tube 1 3414 to return to its original position.

[0053] From the above, it can be seen that: the test tube 1 3414 can be tilted when the turntable 32 rotates at a high speed through the rotation tilting mechanism 34. Under the action of centrifugation, the bottom end of the test tube 1 3414 tilts outward. At the same time, the sample in the test tube 1 3414 is stratified under the action of centrifugation. The substances with higher density in the sample will gather outward, that is, at the bottom end of the test tube 1 3414, to facilitate the extraction of the supernatant at a later time.

[0054] Then, the electric cylinder 4 is started again to separate the test tube 1 3414 from the cap 3415 again through the cap assembly and disassembly assembly 5.

[0055] Then, the third motor 67 and the fourth motor 613 of the liquid taking mechanism 6 are started, and the pipette 617 is adjusted to move above one of the test tubes 1 3414. The third electric telescopic rod 615 fixedly connected to the side wall of the translation block 610 is started to push the push block 2 616, so that the push block 2 616 drives the pipette 617 to move downward, so that the pipette nozzle 621 of the pipette 617 enters the test tube 1 3414 to absorb the separated supernatant. Then, the pipette 617 is moved to above the test tube 2 620 on the second mounting platform 62, and the supernatant in the pipette nozzle 621 of the pipette 617 is injected into the test tube 2 620, thereby completing the transfer of the supernatant.

[0056] It should be noted that the pipette nozzle 621 at the lower end of the pipette 617 can be automatically replaced. This is a prior art and will not be elaborated on here. When the pipette nozzle 621 of the pipette 617 completes the transfer of the supernatant in one of the test tubes 3414, the position of the pipette 617 is adjusted to above the waste storage chamber 622. The old pipette nozzle 621 will fall off from the lower end of the pipette 617 into the waste storage chamber 622. Then the pipette 617 is adjusted to replace the new pipette nozzle 621. This can avoid the contamination of biological samples caused by repeated use of the pipette nozzle 621, which will affect the test results.

[0057] From the above, it can be seen that through the cooperation of the oscillating mechanism 2, the centrifugal assembly 3, the cap assembly and disassembly assembly 5 and the liquid collection mechanism 6, the entire process of biological sample processing can be completed on this device, avoiding cumbersome operating steps, reducing the labor intensity of operators, and preventing errors caused by manual operation from affecting subsequent detection results. It also improves the efficiency of biological sample processing while reducing the technical difficulty of biological sample processing.

[0058] The embodiments of the present invention are provided for the purpose of illustration and description. Although the embodiments of the present invention have been shown and described above, it can be understood that the above embodiments are exemplary and cannot be understood as limitations of the present invention. Ordinary technicians in this field can change, modify, replace and modify the above embodiments within the scope of the present invention.

Claims

1. A fully automatic biological sample processing device, comprising: The frame (1) is characterized in that: an oscillating mechanism (2) is installed at the bottom of the inner wall of the frame (1), and the oscillating mechanism (2) comprises a base (21), the top of the base (21) is rotatably connected to a Z-shaped support rod (22), the top of the Z-shaped support rod (22) is rotatably connected to a shaking plate (23), the top of the base (21) is rotatably connected to a rotating shaft (24), the top of the rotating shaft (24) is fixedly connected to a connecting rod (25), the top of the connecting rod (25) is penetrated by a shaft rod (26), one end of the shaft rod (26) is fixedly connected to the bottom of the shaking plate (23), a first bevel gear (27) is fixedly connected to the rotating shaft (24), and the top of the base (21) is close to the first bevel gear. A first motor (28) is fixedly connected to the position of (27), the output end of the first motor (28) is fixedly connected to a second bevel gear (29), the second bevel gear (29) is meshed with the first bevel gear (27), a centrifugal assembly (3) is arranged on the top of the shaking plate (23), an electric cylinder (4) is fixedly connected to the top of the inner wall of the frame (1), a push plate (41) is fixedly connected to the output end of the electric cylinder (4), a plurality of mounting plates (42) are fixedly connected to the bottom of the push plate (41), a cap assembly and disassembly assembly (5) is installed on the mounting plate (42), the cap assembly and disassembly assembly (5) is located directly above the centrifugal assembly (3), and a liquid extraction mechanism (6) is arranged on one side of the inner wall of the frame (1).

2. The fully automatic biological sample processing device according to claim 1, characterized in that: The centrifugal assembly (3) comprises a sleeve (31) fixed on the top of the shaking plate (23); the top of the sleeve (31) is rotatably connected to a turntable (32) via a bearing; a second motor (33) is fixedly mounted on the inner side of the sleeve (31) at the top of the shaking plate (23); the output end of the second motor (33) is fixedly connected to the bottom of the turntable (32); and a plurality of rotation-inclined mechanisms (34) are mounted on the top of the turntable (32).

3. The fully automatic biological sample processing device according to claim 2, characterized in that: The rotating tilt mechanism (34) comprises a mounting component (341) and a limiting plate (342). The bottom of the mounting component (341) is fixedly connected to the top of the turntable (32). The bottom of the limiting plate (342) is fixed to the edge of the top of the turntable (32). A counterweight (343) is arranged between the side wall of the limiting plate (342) and the side wall of the mounting component (341). A pair of sliding rods (344) are arranged through the side wall of the counterweight (343). The counterweight (343) is slidably connected to the sliding rod (344). The two ends of the sliding rod (344) are respectively fixedly connected to the side wall of the limiting plate (342) and the side wall of the mounting component (341). A spring (345) is sleeved on the outside of the sliding rod (344). The two ends of the spring (345) are respectively fixedly connected to the side wall of the counterweight (343) and the side wall of the limiting plate (342).

4. The fully automatic biological sample processing device according to claim 3, characterized in that: The rotating and tilting mechanism (34) also includes a tube loader (346), the bottom end of which is rotatably connected to the top of the counterweight (343), the side wall of the mounting component (341) is provided with a first slide groove (347), and both sides of the inner wall of the first slide groove (347) are provided with limiting grooves (348), a first slider (349) is slidably installed in the first slide groove (347), both sides of the first slider (349) are fixedly connected to limiting blocks (3410), the limiting blocks (3410) extend into the limiting groove (348), one side of the first slider (349) is fixedly connected to a rod body (3411), and the other end of the rod body (3411) is rotatably connected to the side wall of the tube loader (346).

5. The fully automatic biological sample processing device according to claim 4, characterized in that: The top of the tube loader (346) is provided with a socket (3412), the inner wall of the socket (3412) is provided with a cushion (3413), the socket (3412) is inserted with a test tube 1 (3414), and the top of the test tube 1 (3414) is threadedly connected with a cap (3415).

6. The fully automatic biological sample processing device according to claim 1, characterized in that: The cap assembly and disassembly component (5) comprises a first through slot (51) formed on the mounting plate (42), second slide slots (52) are formed on both sides of the inner wall of the first through slot (51), a second slider (53) is slidably mounted in the first through slot (51) through the second slide slot (52), one side of the second slider (53) extends out of the first through slot (51) and is fixedly connected to a capping machine (54), the other side of the second slider (53) is fixedly connected to a fixing plate (55), a side of the mounting plate (42) away from the capping machine (54) is fixedly connected to a first electric telescopic rod (56), and an output end of the first electric telescopic rod (56) is fixedly connected to a side wall of the fixing plate (55).

7. The fully automatic biological sample processing device according to claim 6, characterized in that: A second through slot (57) is provided at the bottom end of the side wall of the mounting plate (42), and a third sliding slot (58) is provided at the top and bottom of the inner wall of the second through slot (57). A pair of third sliding blocks (59) are installed in the second through slot (57) through the third sliding slot (58), and one side of the pair of third sliding blocks (59) is fixedly connected with a clamping claw (510), and the clamping claw (510) is located below the capping machine (54). A side of the third sliding block (59) away from the clamping claw (510) is rotatably connected with a push rod (511) through an axle pin, and the other end of the push rod (511) is rotatably connected with a push block 1 (512) through an axle pin. A second electric telescopic rod (513) is provided on one side of the push block 1 (512), and an output end of the second electric telescopic rod (513) is fixedly connected to the top of the push block 1 (512), and the second electric telescopic rod (513) is fixedly connected to the side wall of the mounting plate (42).

8. The fully automatic biological sample processing device according to claim 1, characterized in that: The liquid extraction mechanism (6) includes a first mounting platform (61) and a second mounting platform (62) fixed to one side of the inner wall of the frame body (1). A third through groove (63) is formed at the bottom of the inner wall of the first mounting platform (61). Fourth sliding grooves (64) are formed on both sides of the inner wall of the third through groove (63). An L-shaped moving block (65) is slidably mounted in the third through groove (63) through the fourth sliding grooves (64). A first lead screw (66) penetrates through the side wall of the L-shaped moving block (65) and is threadedly connected to the first lead screw (66). One end of the first lead screw (66) is rotatably connected to one side of the inner wall of the first mounting platform (61). The other end of the first lead screw (66) is connected to a third motor (67). The bottom of the third motor (67) is fixedly connected to the bottom of the inner wall of the first mounting platform (61).

9. The fully automatic biological sample processing device according to claim 8, characterized in that: One side of the L-shaped moving block (65) is fixedly connected with a C-shaped member (68). A partition plate (69) is fixedly connected to the inner wall of the C-shaped member (68). A translation block (610) is arranged inside the C-shaped member (68). A second lead screw (611) and a limiting rod (612) respectively penetrate through the side wall of the translation block (610). The translation block (610) is threadedly connected to the second lead screw (611). The translation block (610) is slidably connected to the limiting rod (612). One end of the second lead screw (611) is rotatably connected to one side of the inner wall of the C-shaped member (68). The other end of the second lead screw (611) penetrates through the partition plate (69) and is connected to a fourth motor (613). And the second lead screw (611) is rotatably connected to the partition plate (69). One side of the fourth motor (613) is fixedly connected to the inner wall of the C-shaped member (68). Both ends of the limiting rod (612) are respectively fixedly connected to one side of the inner wall of the C-shaped member (68) and the side wall of the partition plate (69). A liquid adding device (614) is mounted on the side wall of the translation block (610). A third electric telescopic rod (615) is fixedly connected to the position on the side wall of the translation block (610) far away from the liquid adding device (614). The output end of the third electric telescopic rod (615) is fixedly connected to a second push block (616). A pipette (617) is mounted at one end of the second push block (616).

10. The fully automatic biological sample processing device according to claim 9, characterized in that: A plurality of first sockets (618), a plurality of second sockets (619) and a waste storage cavity (622) are formed at the top of the second mounting platform (62). A second test tube (620) is inserted into each of the plurality of first sockets (618). A plurality of pipette tips (621) are inserted into each of the plurality of second sockets (619).

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