Traditional Chinese medicine composition for treating recurrent intussusception and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating recurrent intussusception. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine components in percentage by weight: 8.1% of fennel, 16.3% of rhizoma corydalis, 9.8% of angelica sinensis, 9.8%-12.8% of ligusticum wallichii, 9.8% of radix paeoniae rubra, 8.1%-12.8% of peach kernel, 8.1% of fried fructus aurantii, 9.8% of radix bupleuri, 9.8%-12.8% of trogopterus dung and 9.8%-12.8% of pollen typhae. According to the traditional Chinese medicine composition for treating the recurrent intussusception, the fennel is used for warming channels and expelling cold and dredging lower jiao; corydalis tuber can regulate qi, dissipate blood stasis, relieve swelling and relieve pain; ligusticum wallichii is a medicine for qi in blood, and is matched with angelica sinensis and radix paeoniae rubra to activate blood and promote qi circulation; fructus aurantii and radix bupleuri regulate qi and remove stagnation; peach kernel, trogopterus dung and pollen typhae promote blood circulation, remove blood stasis and relax the bowels; the effects of regulating qi, activating blood, warming, dissipating heat and relieving pain are achieved; the traditional Chinese medicine composition is used for treating and improving local blood circulation of intestinal tracts of sick children to prevent repeated attack of intussusception, especially idiopathic intussusception, so that pain of the sick children caused by diseases is reduced, and the traditional Chinese medicine composition has unique advantages in prevention and conditioning starting from integral regulation, including oral decoction and external treatment.

Description

Technical Field

[0001] The invention relates to a traditional Chinese medicine composition for treating recurrent intussusception and a preparation method thereof. Background Art

[0002] Recurrent intussusception refers to intussusception, a pathological condition in which a part of the intestinal tube (the intussusception end) is embedded in the adjacent intestinal tube (the intussusception sheath) along the intestinal axis, causing intestinal obstruction and blood circulation disorders, which reappears after repositioning treatment. The cause of this disease is complex. It is more common in children as idiopathic, while in adults it is more secondary to anatomical lesions or functional factors. Most patients recover well after treatment, but the recurrence rate is high, about 10% to 20%, especially when the cause is not resolved or the intestinal function is abnormal. It is an important research and treatment difficulty in pediatrics and digestive surgery.

[0003] At present, Western medicine treatment is mainly based on symptomatic treatment and etiological intervention, mainly including non-surgical treatment, surgical treatment and drug treatment, emphasizing reduction and surgery. There are the following major defects in Western medicine treatment: 1. High recurrence rate; 2. Lack of radical treatment for the cause; 3. Limitation of drug treatment; 4. Postoperative complications and recurrence risk; 5. Limited means of preventing recurrence: Western medicine has not developed effective measures to prevent recurrence, and patients still have a high risk of recurrence after receiving non-surgical or surgical treatment.

[0004] In summary, the current treatment methods of Western medicine mainly focus on symptomatic treatment and mechanical reduction. Although the reduction success rate of intussusception is high, it still has limitations in preventing disease recurrence and treating the cause. There are still great limitations in the etiological treatment and long-term management of recurrence. This is also the key direction for future research and treatment improvements. Summary of the invention

[0005] The invention provides a traditional Chinese medicine composition for treating recurrent intussusception and a preparation method thereof.

[0006] The technical solution adopted by the present invention to solve the above technical problems is:

[0007] A traditional Chinese medicine composition for treating recurrent intussusception comprises traditional Chinese medicine components prepared in the following proportions: 8.1% of fennel, 16.3% of Corydalis yanhusuo, 9.8% of angelica sinensis, 9.8%-12.8% of chuanxiong, 9.8% of red peony root, 8.1%-12.8% of peach kernel, 8.1% of stir-fried fructus aurantii, 9.8% of bupleurum, 9.8%-12.8% of truncatum fat, and 9.8%-12.8% of raw pollen.

[0008] Preferably, the Chinese medicine composition is formulated in the following weight ratio: 5 grams of fennel, 10 grams of Corydalis yanhusuo, 6 grams of angelica, 6-10 grams of Chuanxiong, 6 grams of red peony root, 5-10 grams of peach kernel, 5 grams of stir-fried Citrus aurantium, 6 grams of bupleurum, 6-10 grams of Notopterygium wilfordii, and 6-10 grams of raw Pollen Typhae.

[0009] Preferably, the Chinese medicine composition can be taken orally in the form of a decoction.

[0010] Preferably, the Chinese medicine composition can be used for external treatments, including Chinese medicine hot compress and acupuncture.

[0011] Preferably, fennel is obtained by stir-frying, Corydalis yanhusuo is obtained by vinegar, angelica is obtained by wine, Ligusticum chuanxiong is obtained by stir-frying, Citrus aurantium is obtained by stir-frying, and Atractylodes macrocephala is obtained by stir-frying.

[0012] A method for preparing a Chinese medicine composition for treating recurrent intussusception comprises the following steps:

[0013] S1. Soak the above drugs in cold water for 20-30 minutes;

[0014] S2. Bring the Chinese medicine to a boil over high heat, then turn to low heat and continue boiling for about 20 minutes;

[0015] S3, pour out the medicine juice, drain the water from the Chinese medicine composition, add water and repeat steps S1 and S2;

[0016] S4. Mix the two decoctions and divide them into two equal parts.

[0017] Preferably, in step S1, the amount of water exceeds the amount of the drug by 1-2 fingers.

[0018] Compared with the prior art, the Chinese medicine composition for treating recurrent intussusception of the present invention warms the meridians and dispels cold, and reaches the lower part of the body through fennel; Corydalis yanhusuo regulates qi and dissipates blood stasis, reduces swelling and relieves pain; Chuanxiong is a qi medicine in the blood, and is combined with angelica and red peony root to promote blood circulation and qi; Citrus aurantium and Bupleurum regulate qi and relieve stagnation; peach kernel, aconiti lobata and raw pollen promote blood circulation and remove blood stasis, and also have laxative effects; it has the effects of regulating qi and activating blood circulation, warming and dispersing pain; Chinese medicine is used to treat and improve the local blood circulation of the intestine of the child to prevent the recurrence of intussusception, especially idiopathic intussusception, thereby reducing the pain caused by the disease in the child; the Chinese medicine composition starts with overall regulation, including internal decoctions and external treatments, and has unique advantages in prevention and conditioning. DETAILED DESCRIPTION

[0019] The present invention is further described in detail below with reference to the embodiments.

[0020] A Chinese medicine composition for treating recurrent intussusception, comprising Chinese medicine components prepared in the following proportions: 8.1% fennel, 16.3% yanhusuo, 9.8% angelica, 9.8%-12.8% chuanxiong, 9.8% red peony root, 8.1%-12.8% peach kernel, 8.1% stir-fried fructus aurantii, 9.8% bupleurum, 9.8% truncatum 9.8%-12.8%, and raw pollen 9.8%-12.8%; the Chinese medicine composition can be taken orally as a decoction or used for external treatments, including Chinese medicine hot compresses, acupuncture, etc.

[0021] In this embodiment, the Chinese medicine composition for treating recurrent intussusception is composed of 5 grams of fennel, 10 grams of Corydalis yanhusuo, 6 grams of angelica, 6-10 grams of Chuanxiong, 6 grams of red peony root, 5-10 grams of peach kernel, 5 grams of stir-fried Citrus aurantium, 6 grams of Bupleurum, 6-10 grams of Ophiopogon japonicus, and 6-10 grams of raw Pollen Typhae.

[0022] The processing method of each component in the traditional Chinese medicine composition is as follows: frying fennel, yanhusuo with vinegar, angelica with wine, chuanxiong, fructus aurantii and tsuruha are fried; frying fennel enhances the warming and cold-dispelling effects, vinegar-prepared yanhusuo enhances the qi-regulating effects, wine-prepared angelica enhances the warming and blood-activating effects, frying chuanxiong enhances the blood-activating and blood-stasis-removing effects, frying fructus aurantii enhances the qi-regulating effects, and frying tsuruha enhances the blood-activating and blood-stasis-removing effects.

[0023] A method for preparing a Chinese medicine composition for treating recurrent intussusception comprises the following steps:

[0024] S1. Soak the above drugs in cold water for 20-30 minutes;

[0025] The amount of water exceeds the amount of medicine by 1-2 fingers.

[0026] S2. Bring the Chinese medicine to a boil over high heat, then turn to low heat and continue boiling for about 20 minutes;

[0027] S3, pour out the medicine juice, drain the water from the Chinese medicine composition, add water and repeat steps S1 and S2;

[0028] S4. Mix the two decoctions and divide them into two equal parts.

[0029] The decocted medicine juice can be taken twice a day, morning and evening, or after meals.

[0030] The Chinese medicine composition is taken orally: for children aged 2-4, take it twice a day, 100 ml each time; for children aged 5-8, take it twice a day, 150 ml each time; for children aged 9-14, take it twice a day, 200 ml each time.

[0031] Traditional Chinese medicine believes that the occurrence of intussusception is mostly due to changes in diet, environment, and climate, which lead to disordered intestinal qi and blood vessels. If the blood vessels are blocked for a long time, it is difficult for qi and blood to flow smoothly after restoration, resulting in repeated attacks. As the saying goes, "Long-term pain is in the collaterals, and the collaterals are responsible for blood. Not only the pain of the limbs is in the collaterals, but also the pain of the chest and abdomen, and the pain of lumps are all in the collaterals. They should all be activated, not just qi." Qi is the leader of blood, and blood is the mother of qi. When qi flows, blood flows, and when qi stagnates, blood stagnates. Conversely, blood stasis will inevitably lead to poor qi. Therefore, qi and blood are inseparable, and those who activate blood must take qi into consideration. Therefore, the main treatment method for this disease should be to understand the purpose of regulating qi and activating blood, warming and dispersing to relieve pain.

[0032] The functions of each component in the Chinese medicine composition are as follows:

[0033] Fennel: It is the dried mature fruit of the umbelliferae plant fennel. It is pungent and warm in nature. It belongs to the liver, kidney, spleen and stomach meridians. It has the effects of dispelling cold and relieving pain, regulating qi and harmonizing the stomach. Salt fennel also warms the kidney, dispels cold and relieves pain. It is used for abdominal pain caused by cold hernia, testicular prolapse, dysmenorrhea, cold pain in the lower abdomen, abdominal distension and pain, and vomiting and diarrhea due to poor appetite. Salt fennel is used for abdominal pain caused by cold hernia, testicular prolapse, and abdominal pain caused by cold menstruation. Pharmacological effects show that fennel has antispasmodic effects, which can relax intestinal smooth muscles and relieve spasmodic pain. It also has antioxidant and free radical scavenging effects, which can reduce tissue oxidative damage, thereby indirectly relieving pain caused by inflammation or injury. The digestive effect is mainly manifested in the anisole and anisone it contains, which can stimulate gastrointestinal smooth muscles, promote the secretion of digestive juices, and increase gastrointestinal motility.

[0034] Yanhusuo: It is the dried tuber of the poppy family plant Yanhusuo. It tastes pungent and bitter, is warm in nature, and enters the liver and spleen meridians. It has the effects of promoting blood circulation, promoting qi, and relieving pain. It is used for chest and rib pain, abdominal pain, chest pain, heart pain, amenorrhea, dysmenorrhea, postpartum blood stasis, and swelling and pain from falls. Pharmacological effects show that Yanhusuo has a significant analgesic effect on the nervous system. The analgesic potency of the powder is about 1% of opium, which can effectively relieve chest and rib pain, stomach pain, and pain from falls.

[0035] Angelica: It is the dried root of the Umbelliferae plant Angelica sinensis. It tastes sweet and spicy, is warm in nature, and enters the liver, heart, and spleen meridians. It has the effects of nourishing blood and activating blood circulation, regulating menstruation and relieving pain, and moistening the intestines and relieving constipation. It is used for blood deficiency and sallow complexion, dizziness and palpitations, irregular menstruation, amenorrhea and dysmenorrhea, asthenic abdominal pain, rheumatic arthralgia, injuries from falls, carbuncle, ulcers, and constipation caused by dry intestines. Wine Angelica can activate blood circulation and regulate menstruation. It is used for amenorrhea and dysmenorrhea, rheumatic arthralgia, and injuries from falls. Pharmacological effects show that Angelica sinensis has anti-thrombotic effects, improves blood circulation, and has a spasmolytic effect on vascular smooth muscle.

[0036] Chuanxiong: It is the dried rhizome of the plant Chuanxiong of the Umbelliferae family. It is pungent in taste and warm in nature. It enters the liver, gallbladder and pericardium meridians and has the effects of promoting blood circulation and qi, dispelling wind and relieving pain. It is used for irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain due to lumps, stabbing pain in the chest and ribs, swelling and pain due to falls, headache, and rheumatic pain. Pharmacological effects show that ligustrazine in Chuanxiong can reduce platelet surface activity, inhibit platelet aggregation, and prevent the formation of thrombus.

[0037] Red peony root: It is the dried root of the Ranunculaceae plant Paeonia lactiflora or Sichuan red peony root. It tastes bitter, is slightly cold in nature, and belongs to the liver meridian. It has the effects of clearing heat and cooling blood, dispersing blood stasis and relieving pain. It is used for heat entering the blood, warm toxins causing spots, vomiting blood and epistaxis, red and swollen eyes, liver depression and flank pain, amenorrhea and dysmenorrhea, abdominal pain due to lumps, injuries from falls, carbuncles and ulcers. After frying, the nature of red peony root tends to be mild, it can promote blood circulation and relieve pain without hurting the middle, and can be used for pain caused by blood stasis; after drinking, red peony root is better at promoting blood circulation and dispersing blood stasis, and its effect of clearing heat and cooling blood is weak, and it is mostly used for amenorrhea or dysmenorrhea, and injuries from falls. Pharmacological effects show that the effects of red peony root on the blood system are mainly anticoagulant, anti-blood, and vasodilation, and it is found that total glycosides of red peony root can promote gastrointestinal smooth muscle motility.

[0038] Peach kernel: It is the dried mature seed of peach, a plant of the Rosaceae family. It tastes bitter and sweet, is neutral in nature, and is in the heart, liver, and large intestine meridians. It has the effects of promoting blood circulation and removing blood stasis, moistening the intestines and relieving constipation, and relieving cough and asthma. It is used for amenorrhea, dysmenorrhea, abdominal masses, lung abscesses, intestinal abscesses, injuries from falls, constipation due to dry intestines, and cough and asthma. The pharmacological effects show that peach kernel has the effect of removing blood stasis, increasing venous blood flow, and achieving vasodilation, and also inhibiting blood coagulation and hemolysis.

[0039] Citrus aurantium: It is the dried immature fruit of the plant Citrus aurantium and its cultivated varieties of the Rutaceae family. It tastes bitter, pungent, and sour, is slightly cold in nature, and enters the spleen and stomach meridians. It has the effects of regulating qi, relieving fullness, and relieving stagnation and bloating. It is used for chest and flank qi stagnation, fullness and pain, indigestion, phlegm and fluid retention, and organ ptosis. Pharmacological effects show that the volatile oils and flavonoids contained in Citrus aurantium can enhance the contractility of gastrointestinal smooth muscles, promote gastrointestinal motility, improve digestive function, and relieve flatulence.

[0040] Bupleurum: It is the dried root of the Umbelliferae plant Bupleurum or Angustifolia. It tastes pungent and bitter, is slightly cold in nature, and enters the liver, gallbladder, heart, and triple burner meridians. It has the effects of reconciling the exterior and interior, soothing the liver and relieving depression, raising yang and lifting depression, and reducing fever and stopping malaria. It is used for colds and fever, alternating cold and heat, chest and flank pain, irregular menstruation, uterine prolapse, and rectal prolapse. Pharmacological effects show that Bupleurum can stimulate gastrointestinal motility, promote digestion and absorption, and relieve symptoms such as gastrointestinal discomfort.

[0041] Wulingzhi: It is the dried feces of the orange-footed flying squirrel and flying squirrel of the family Sciuridae. It tastes bitter and sweet, is warm in nature, and enters the liver and spleen meridians. Wulingzhi is used raw to promote blood circulation and relieve pain. It can treat various pains caused by blood and qi in the heart and abdomen, amenorrhea in women, and pain caused by blood stasis after childbirth. It can also be used externally to treat bites by snakes, scorpions, and centipedes. It can be used to stop bleeding when fried, and can treat metrorrhagia, excessive menstruation, and continuous red discharge in women. Pharmacological effects show that Wulingzhi has the effect of relieving smooth muscle spasms. It has also been used clinically for angina pectoris; it also has the effect of enhancing in vitro fibrinolysis.

[0042] Typhae pollen: It is the dried pollen of Typha truncatum, Typha orientalis or the same genus of Typhaceae. It is sweet, neutral in nature, and enters the liver and pericardium meridians. It has the effects of hemostasis, blood stasis, and stranguria. It is used for hematemesis, epistaxis, hemoptysis, metrorrhagia, traumatic bleeding, amenorrhea, stabbing pain in the chest and abdomen, swelling and pain due to falls, and bloody stranguria. Pharmacological effects show that Typhae pollen has a spasmolytic effect on the intestine and can also prevent the formation of intestinal adhesions.

[0043] The Chinese medicine composition for treating recurrent intussusception of the present invention warms the meridians and dispels cold, and reaches the lower part of the body; Corydalis yanhusuo regulates qi and dissipates blood stasis, relieves swelling and relieves pain; Chuanxiong is a qi medicine in the blood, and is combined with angelica and red peony root to promote blood circulation and qi; Citrus aurantium and Bupleurum regulate qi and relieve stagnation; peach kernel, aconiti lobata and raw pollen promote blood circulation and remove blood stasis, and also have laxative effects; it has the effects of regulating qi and promoting blood circulation, warming and dispersing pain; Chinese medicine is used to treat and improve the local blood circulation of the intestine of children, so as to prevent the recurrence of intussusception, especially idiopathic intussusception, thereby reducing the pain caused by the disease in children; the Chinese medicine composition starts with overall regulation, including internal decoctions and external treatments, and has unique advantages in prevention and conditioning.

[0044] Finally, it should be noted that the above embodiments only illustrate the technical solutions of the present invention, rather than limiting it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A Chinese medicine composition for treating recurrent intussusception, characterized in that: It includes Chinese medicinal components in the following proportions: 8.1% fennel, 16.3% Corydalis yanhusuo, 9.8% angelica, 9.8%-12.8% ligusticum chuanxiong, 9.8%-12.8% red peony root, 8.1%-12.8% peach kernel, 8.1%-12.8% stir-fried fructus aurantii, 9.8% bupleurum, 9.8%-12.8% aconiti lobata, and 9.8%-12.8% raw pollen.

2. The Chinese medicine composition for treating recurrent intussusception according to claim 1, characterized in that: The Chinese medicine composition is prepared in the following proportions by weight: 5 grams of fennel, 10 grams of Corydalis yanhusuo, 6 grams of angelica sinensis, 6-10 grams of Chuanxiong, 6 grams of red peony root, 5-10 grams of peach kernel, 5 grams of stir-fried Citrus aurantium, 6 grams of Bupleurum chinense, 6-10 grams of Ophiopogon japonicus, and 6-10 grams of raw Pollen Typhae.

3. The Chinese medicine composition for treating recurrent intussusception according to claim 1 or 2, characterized in that: The Chinese medicine composition can be taken orally in the form of a decoction.

4. The Chinese medicine composition for treating recurrent intussusception according to claim 1 or 2, characterized in that: The Chinese medicine composition can be used for external treatments, including Chinese medicine hot compress and acupuncture.

5. The Chinese medicine composition for treating recurrent intussusception according to claim 1 or 2, characterized in that: Fennel is obtained by frying, Corydalis yanhusuo is obtained by making vinegar, angelica is obtained by making wine, Chuanxiong is obtained by frying, Citrus aurantium is obtained by frying, and Aconiti lobata is obtained by frying.

6. A method for preparing a Chinese medicine composition for treating recurrent intussusception, characterized in that: The following steps are involved: S1. Soak the above drugs in cold water for 20-30 minutes; S2. Bring the Chinese medicine to a boil over high heat, then turn to low heat and continue boiling for about 20 minutes; S3, pour out the medicine juice, drain the water from the Chinese medicine composition, add water and repeat steps S1 and S2; S4. Mix the two decoctions and divide them into two equal parts.

7. The method for preparing the Chinese medicine composition for treating recurrent intussusception according to claim 6, characterized in that: In step S1, the amount of water exceeds the medicine by 1-2 fingers.