Medicine applying device for transdermal patch production

Abstract

A medicine coating device for transdermal patch production belongs to the technical field of medicine production equipment, and comprises a workbench, an unwinding seat, an electric winding mechanism, an electric heating drying box, a glue coating roller, a guide roller, a scraping roller, a guide seat, a pressure sensor, a motor reducing mechanism, a dredging mechanism, a control circuit, a detection circuit and a trigger circuit, the unwinding seat, the electric winding mechanism, the electric heating drying box, the glue spreading roller, the guide roller, the scraping roller, the guide seat, the pressure sensor and the motor reducing mechanism are arranged on the workbench, and the control circuit, the detection circuit and the trigger circuit are arranged in the electric control box. According to the device, the gluing roller can be driven to do reciprocating motion to coat the transdermal patch with a viscous medicament, and when the gluing roller is blocked by a glue hole, a power supply of related equipment can be turned off, and the glue hole is automatically dredged through the dredging mechanism, so that uniform coating of the viscous medicament is ensured, the transdermal patch production quality and the production efficiency are improved, and the production cost is reduced. And convenience is also correspondingly brought to workers.

Description

Technical Field

[0001] The invention relates to the technical field of auxiliary equipment for drug production, in particular to a drug coating device used in the production of transdermal patches. Background Art

[0002] The transdermal patch is a dosage form for transdermal drug delivery, which is used on the intact skin surface. When using the transdermal patch, the user tears off the protective film and sticks it on the outside of the skin. The drug is delivered through the skin barrier into the blood circulation system to exert a systemic effect. The transdermal patch delivery method can make drug absorption unaffected by factors such as pH, food, and transit time in the digestive tract, and can also avoid the first-pass effect of the liver. Transdermal patches can achieve flexible drug delivery, which can be administered for a long time or stopped at any time. They are particularly suitable for infants, children with poor medication compliance, and elderly people with weak swallowing ability.

[0003] Existing transdermal patches vary in type. Some have a layer of sticky medicine adhered to the inner surface of the transdermal patch (generally non-woven fabric) (the entire inner side of the transdermal patch is in one plane), and some have a layer of medicine protruding from the inner surface of the transdermal patch adhered to the middle of the inner side by heating or the like. In the current production of adhesive transdermal patches, the drug-carrying surface is generally coated with adhesive drugs by a coating roller. Specifically, the drug liquid in the drug box located at a high position flows into the coating roller (after the drug is added to the drug box, the sealing cover is closed, and the compressed air output by the air compressor enters the drug box through the upper end of the drug box to ensure that the drug box has a suitable pressure. The pressurized drug entering the coating roller can increase the fluidity of the drug and achieve a better uniform coating effect). Then the drug liquid flows out from the multiple glue holes distributed laterally at the lower end of the coating roller and is laterally coated on the transdermal patch that is constantly moving from front to back. The scraper roller at the rear side of the coating roller scrapes the drug liquid flat (so that the drug liquid is as evenly distributed on the transdermal patch as possible), and then the finished transdermal patch is obtained by drying and rolling it up with a drying device. Although in the existing production of transdermal patches, the coating of transdermal patches with adhesive drugs by the coating roller can meet the production needs to a certain extent, it is limited by the structure and still has the following technical disadvantages. First, the glue roller is in a fixed state when applying the viscous medicine. In this way, the medicine cannot effectively cover the entire surface of the transdermal patch when it flows out from the lower end of the multiple glue holes of the glue roller. Especially when one or more glue holes are blocked, since there is relatively little viscous medicine on the transdermal patch, even after the subsequent scraping roller is scraped flat, it cannot be guaranteed that the viscous medicine will fully cover the transdermal patch, which will have an adverse effect on the quality of the transdermal patch (for example, a corresponding position of the transdermal patch lacks medicine). Second, when the glue hole of the glue roller is blocked, it cannot promptly remind the staff to perform maintenance in time, and it cannot automatically dredge the glue hole, which will have an adverse effect on the production quality of the transdermal patch. In addition, the staff manually shuts down the equipment to dredge the glue hole, which will not only cause inconvenience to the staff, but also be unfavorable to improving work efficiency. Summary of the invention

[0004] In order to overcome the drawbacks of the existing glue coating roller used in the production of transdermal patches due to structural limitations as described in the background, the present invention provides a coating device for transdermal patch production, in which the glue coating roller can reciprocate left and right to apply the viscous agent under the joint action of relevant mechanisms, and when the glue hole of the glue coating roller is blocked, the power supply of the relevant equipment can be turned off in time, and the glue hole can be automatically unblocked, thereby ensuring the uniform application of the viscous agent as much as possible, improving the quality of the production of transdermal patches, and correspondingly bringing convenience to the staff and improving the work efficiency.

[0005] The technical solution adopted by the present invention to solve its technical solution is:

[0006] A drug coating device for transdermal patch production, comprising a workbench, an unwinding seat, an electric rewinding mechanism, an electric heating drying box, a glue coating roller, a guide roller, a scraper roller, a guide seat, a pressure sensor, a motor deceleration mechanism, and also having a dredging mechanism, a control circuit, a detection circuit, and a trigger circuit; the unwinding seats are at least two, the upper ends of the two unwinding seats are provided with support holes, the lower ends of the two unwinding seats are respectively mounted on the upper front part of the workbench, and the guide roller is mounted on the rear end of the unwinding seat; the guide seats are multiple, each guide seat has a special-shaped guide hole, wherein The lower end of a guide seat is installed at one end of the rear side of the guide roller, and the lower ends of the other two guide seats are installed at the other end of the rear side of the guide roller at a distance; the two side ends of the glue coating roller are respectively installed with special-shaped connecting pipes, and the connecting pipes at the two side ends of the glue coating roller are respectively slidably sleeved in the guide holes of the multiple guide seats, one end of the connecting pipe and the air inlet pipe of the pressure sensor are installed together, and the other end of the connecting pipe and the liquid outlet end of an electromagnetic valve are installed together and connected, the liquid inlet end of the electromagnetic valve and the liquid outlet pipe at the lower end of the medicine box are connected through a hose, and the connecting pipe at the other end of the glue coating roller is located at The outer sleeve of the guide seat is provided with a spring, and the outer end of the connecting pipe at the other end is provided with a top plate, the motor reduction mechanism is provided with a rear end of the top plate, and the front end of the rotating shaft of the motor reduction mechanism is provided with an eccentric wheel; the scraper roller, the electric heating drying box, and the electric winding mechanism are provided with a front and rear interval in sequence at the rear end of the glue coating roller; the dredging mechanism comprises an electric push rod, a connecting plate, and a dredging needle, the upper end of the glue coating roller has an opening, the cylinder of the electric push rod is provided with a hole outside the opening of the glue coating roller, and the push column of the electric push rod is located inside the glue coating roller, and the connecting plate is provided transversely on the electric push rod At the lower end of the push column, the upper ends of multiple unblocking needles are installed at the lower end of the connecting plate at a distance; the control circuit, detection circuit, and trigger circuit are installed in the electric control box, the power output end of the trigger circuit is electrically connected to the power input end of the control circuit, and the power output end of the control circuit is electrically connected to the power input end of the electric push rod; the signal output end of the detection circuit is electrically connected to the signal input end of the trigger circuit, and the control power output end of the trigger circuit is electrically connected to the motor reduction mechanism M, the motor reduction mechanism A, and the power input end of the electromagnetic valve.

[0007] Furthermore, the number of the dredging needles is consistent with the number of glue holes of the glue coating roller.

[0008] Furthermore, the lower ends of the plurality of dredging needles and the middle parts of the upper ends of the plurality of glue holes are respectively located in a vertical plane, and the lower ends of the dredging needles are pointed cone-shaped, and the outer diameter of the lower ends of the dredging needles is smaller than the outer diameter of the glue holes.

[0009] Furthermore, there is a distance between the lower end of the electric heating drying box, the scraping roller and the guide roller, the lower end of the glue coating roller and the upper end of the workbench.

[0010] Furthermore, the convex surface of the eccentric wheel is in contact with the top plate.

[0011] Furthermore, the electric winding mechanism includes a motor reduction mechanism A and a fixed plate. The middle parts of the upper ends of the two fixed plates are respectively provided with support holes. The motor reduction mechanism A is installed on the rear end of the workbench. The side ends of the rotating shaft of the motor reduction mechanism A and the side ends of the transdermal patch winding drum are respectively provided with connecting plates, and the connecting plates have multiple fixing holes.

[0012] Furthermore, the control circuit includes two sets of electrically connected time-controlled switches, and the power input ends of the two sets of time-controlled switches are respectively connected.

[0013] Furthermore, the trigger circuit includes an electrically connected time relay module, a power switch and a relay, one of the two relays is connected to a control power input end, the other control power input end of the two relays is connected to one end of the two power switches, the other ends of the two power switches are connected, the power output end of the time relay module is connected to the positive power input ends of the two relays, and the negative power input ends of the two relays are connected to the negative power input end of the time relay module and the negative control power input end.

[0014] Furthermore, the detection circuit includes an electrically connected adjustable resistor, a resistor, and a transistor, one end of the adjustable resistor is connected to one end of the first resistor and one end of the second resistor, the other end of the second resistor is connected to the base of the first transistor, the collector of the first transistor is connected to the base of the second transistor, and the other end of the first resistor is connected to the emitter of the first transistor.

[0015] Compared with the prior art, the beneficial effects of the present invention are as follows: under the joint action of relevant mechanisms, the motor reduction mechanism of the present invention can drive the glue coating roller to reciprocate left and right through the eccentric wheel to apply the viscous medicine to the transdermal patch, and when the glue hole of the glue coating roller is blocked, after the pressure sensor detects it, under the action of the detection circuit and the trigger circuit, the power supply of the relevant equipment can be turned off in time, and the glue hole can be automatically unblocked through the control circuit and the unblocking mechanism, thereby ensuring the uniform application of the viscous medicine as much as possible, improving the production quality of the transdermal patch, and correspondingly bringing convenience to the staff and improving the work efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1It is a schematic diagram of the overall structure of the present invention;

[0017] Figure 2 It is a schematic diagram of the local structure of the present invention;

[0018] Figure 3 It is a circuit diagram of the present invention. DETAILED DESCRIPTION

[0019] Figure 1-Figure 3As shown, a drug coating device used in the production of a transdermal patch includes a workbench 1, a reeling seat 2, an electric reeling mechanism, an electric heating drying box 3, a glue coating roller 4 (the lower end has a plurality of glue holes 41 at a lateral spacing), a guide roller 5, a scraper roller 6, a power module T1, a guide seat 7, a pressure sensor T3, a motor reduction mechanism M (a finished product of a coaxial motor gear reducer with a power of 1KW), and also has a dredging mechanism 8, a control circuit 9, a detection circuit 10, and a trigger circuit 11; the reeling seats 2 are provided with two, and a support hole 21 is distributed in the middle of the upper ends of the two reeling seats 2 (the upper ends are open structures), and the lower ends of the two reeling seats 2 are respectively welded to both sides of the middle of the front upper end of the workbench 1, and the left and right ends of the guide roller 5 (for guiding and limiting the drug-carrying material) are provided. The bearing seats are fixedly mounted on both sides of the middle of the upper end of the workbench 1 at the rear end of the unwinding seat; there are three guide seats 7, and each of the three guide seats 7 has a rectangular guide hole 71 in the middle thereof, wherein the lower end of one guide seat 7 is welded to the left side of the workbench 1 at the rear end of the guide roller 5, and the lower ends of the other two guide seats 7 are welded to the right end of the workbench 1 at the rear end of the guide roller 5 at a distance; a rectangular connecting pipe 42 communicating with the inside is welded to the outside of the middle of the left and right ends of the glue coating roller 4, and a sealing plate is welded to the outer ends of the two connecting pipes 42, and the connecting pipes 42 at the left and right ends of the glue coating roller 4 are respectively slidably sleeved in the guide holes 71 of the left and right guide seats 7, and the upper end of the left connecting pipe 7 is welded with a sealing plate communicating with the inside thereof. The branch pipe (located at the left outer end of one of the guide seats) is interconnected internally, and the upper end of the branch pipe is connected to the air inlet pipe of the pressure sensor T3 via a pipe joint; a branch pipe A is welded to the middle part of the connecting pipe between the other two guide seats 7, and the upper end of the branch pipe A is connected to the lower end of an electromagnetic valve DC via a pipe joint, and the upper end of the electromagnetic valve DC is connected to the liquid outlet pipe at the middle part of the lower end of the medicine box (not shown in the figure) via a hose, the connecting pipe at the right end of the glue roller 4 is located at the right guide seat and is covered with a spring 43, and a top plate 44 is welded to the rightmost part of the connecting pipe at the right end of the glue roller, the motor reduction mechanism M is longitudinally fixedly installed on the workbench at the rear end of the top plate 44 by bolts, and an eccentric wheel 12 is welded to the front end of the rotating shaft of the motor reduction mechanism ; The scraper roller 6, the electric heating drying box 3, and the electric winding mechanism are installed on the workbench 1 located at the rear end of the glue coating roller in sequence through bolts; the dredging mechanism includes two electric push rods M2 and a connecting plate 81, and a dredging needle 82. The upper end of the glue coating roller 4 has two openings on the left and right, and the cylinders of the two sets of electric push rods M2 are vertically sealed and installed on the two openings of the glue coating roller 4, and the push columns of the two sets of electric push rods M2 enter the glue coating roller 4 through the openings. The connecting plate 81 is horizontally welded to the lower ends of the push columns of the two sets of electric push rods M2, and the upper ends of multiple dredging needles 83 are respectively welded to the lower ends of the connecting plate 81 at intervals; the power module T1, the control circuit 9, the detection circuit 10, and the trigger circuit 11 are installed in the electric control box 13 at the front end of the workbench.

[0020] Figure 1-Figure 3As shown, the number of dredging needles 83 is consistent with the number of glue holes 41 of the glue coating roller. The lower ends of the plurality of dredging needles 83 and the middle of the upper ends of the plurality of glue holes 41 are respectively in a vertical plane, and the lower ends of the dredging needles 83 are pointed cone-shaped, and the outer diameter of the lower ends of the dredging needles 83 is smaller than the outer diameter of the glue holes 41. The lower end of the electric heating drying box 3, the scraper roller 6 and the guide roller 5, the lower end of the glue coating roller 4 and the upper end of the workbench 1 are spaced apart. The left side of the eccentric wheel 12 is in contact with the right side of the top plate 44. The electric rewinding mechanism includes a motor reduction mechanism AM1 (a finished product of a coaxial motor gear reducer with a power of 1KW), a fixing plate 141, and the middle of the upper end of the two fixing plates 141 respectively has a support hole 1411. The motor reduction mechanism AM1 is fixedly installed on the rear end of the workbench 1 by bolts. The left end of the rotating shaft of the motor reduction mechanism AM1 and the right end of the transdermal patch reel 142 are respectively welded with a connecting plate 143, and the connecting plate 143 has a plurality of fixing holes distributed in an annular manner (the two connecting plates 143 are installed together by bolts). The control circuit includes two sets of time-controlled switches T5 and T6 connected by circuit board wiring, and the power input terminals 1 and 2 of the two sets of time-controlled switches T5 and T6 are connected respectively. The trigger circuit includes a time relay module T4, power switches S1 and S2 and relays J1 and J2 connected via circuit board wiring, one of the control power input ends of the two relays J1 and J2 is connected, the other control power input ends of the two relays J1 and J2 are respectively connected to one end of the two power switches S1 and S2, the other ends of the two power switches S1 and S2 are connected, the power output end 5 pin of the time relay module T4 is connected to the positive power input ends of the two relays J1 and J2, and the negative power input ends of the two relays J1 and J2 are connected to the negative power input end 2 pin of the time relay module T4 and the negative control power input end 4 pin. The detection circuit includes an adjustable resistor RP, resistors R1 and R2, and transistors Q1 and Q2 connected through circuit board wiring. One end of the adjustable resistor RP is connected to one end of the first resistor R1 and one end of the second resistor R2. The other end of the second resistor R2 is connected to the base of the first transistor Q1. The collector of the first transistor Q1 is connected to the base of the second transistor Q2. The other end of the first resistor R1 is connected to the emitter of the first transistor Q1.

[0021] Figure 1-Figure 3As shown, the power input terminals 1 and 2 of the power module T1, one of the control power input terminals of the relays J1 and J2 of the trigger circuit, the other end of the power switches S1 and S2 and the two poles of the AC 220V power supply are connected through wires, the power output terminals 3 and 4 of the power module T1 and the power input terminals 1 and 2 of the pressure sensor T3, the emitter of the transistor Q2 of the power input terminal of the detection circuit and the other end of the resistor R1, and the negative power input terminal of the relay J1 of the power input terminal of the trigger circuit are connected through wires, the power output terminal of the trigger circuit, the time relay module T4, the power input terminal 5 and 2 of the control circuit, the power input terminal 1 and 2 of the time control switch T5 are connected through wires, and the power output terminal 3 and 4 of the control circuit, the positive and negative and the negative and positive power input terminals of the electric push rod M2 are connected through wires. The signal output terminal of the detection circuit, the collector of the transistor Q2, and the positive control power input terminal of the time relay module T4 are connected through wires. The two normally closed contact terminals of relay J1 are connected to the power input terminal of motor reduction mechanism M through wires, the two normally closed contact terminals of relay J2 are connected to the power input terminal of motor reduction mechanism AM1 through wires, and the 5 and 2 pins of time relay module T4 are connected to the power input terminal of electromagnetic valve DC through wires. Power module T1 is a finished product of AC 220V to DC 12V switching power module; the adjustable resistor RP has a resistance value of 10K; the resistance values ​​of resistors R1 and R2 are 1K and 10K respectively; the models of relays J1 and J2 are DC12V; the model of transistor Q1 is 9013 (NPN), the model of transistor Q2 is 9012 (PNP), and the electromagnetic valve DC is a normally open valve core electromagnetic valve; the time control switches T5 and T6 are time relay modules of model KG316, which have two power input terminals, two power output terminals, and seven setting buttons. The seven setting buttons can be operated separately to set the time for the two power output terminals to output power; the time relay module T4 is model Y The YC-2S time relay module is a finished product, which has two power input terminals, two control power input terminals, one power output terminal, and four setting buttons. The four setting buttons can be operated separately to set the time for the power output terminal to output power. Each time the two control power input terminals of the time relay module input a control power signal, the power output terminal will output power; the electric push rod M2 is a 20W reciprocating electric telescopic rod finished product; the pressure sensor T3 is a model LU-THG pressure transmitter finished product, which has two power input terminals and one signal output terminal. Depending on the detected pressure, the signal output terminal will output a voltage signal varying between 0-5V.

[0022] Figure 1-Figure 3As shown, before using the present invention, the shafts at both ends of the feed roller 14 wound with a plurality of turns of transdermal patch raw material are rotated from top to bottom and placed in the support holes 21 at the upper ends of the two sets of unwinding seats 2, and the shafts at both ends of the transdermal patch reel 142 are rotated from top to bottom and placed in the support holes 1411 at the middle of the upper ends of the two fixing plates 141, and the left end of the rotating shaft of the motor reduction mechanism AM1 and the right end connecting plate 143 of the transdermal patch reel 142 are bolted together. Then, the front end of the transdermal patch is passed backwards through the lower end of the guide roller 5, the lower end of the glue coating roller 4, and the lower end of the electric heating drying box 3, and then rolled up on the transdermal patch reel 142 for multiple turns. After the valve at the lower end of the medicine box located at a high position is opened (the solenoid valve DC valve core is opened), the medicine liquid in the medicine box flows into the glue coating roller 4 (the sealing cover of the medicine box is closed after the medicine is added, and the compressed air output by the air compressor enters the medicine box through the upper end of the medicine box to ensure that there is a suitable pressure in the medicine box. The pressurized medicine enters the glue coating roller to increase the fluidity of the medicine and achieve a better uniform coating effect). Then, the medicine liquid flows out from the multiple glue holes 41 distributed laterally at the lower end of the glue coating roller 4 and is laterally coated on the transdermal patch 15 that is constantly moving from front to back. The scraper roller 6 at the rear end of the glue coating roller scrapes the medicine liquid flat (so that the medicine liquid is distributed as evenly as possible on the transdermal patch), and then it is dry-rolled in the electric heating drying box 3 to obtain a finished transdermal patch. After turning on the main power switch, the power module T1 is powered on and starts working. The 3rd and 4th pins of the power module T1 output a stable DC 12V power supply that enters the power input end of the detection circuit and the trigger circuit. After turning on the voltage switches S1 and S2, the motor reduction mechanism M and the motor reduction mechanism AM1 are powered on and start working. After the motor reduction mechanism M is powered on and starts working, its rotating shaft drives the eccentric wheel 12 to rotate. The protruding surface of the eccentric wheel 12 pushes the glue coating roller 4 to move to the left end. When the protruding surface of the eccentric wheel is spaced from the right end of the top plate, the spring 43 pushes the glue coating roller 4 to move to the right. The above process is continuously circulated, and the glue coating roller 4 can reciprocate left and right to apply the viscous drug to the transdermal patch. The coating operation surface is relatively larger (the glue coating roller 4 can reciprocate left and right, and the liquid flowing out of the glue hole can be more evenly distributed on the transdermal patch. After the motor reduction mechanism AM is powered on and starts working, it drives the reel to rotate. After the coating, the finished transdermal patch is rolled up on the reel 142 of the electric rewinding mechanism).

[0023] Figure 1-Figure 3As shown, when the glue hole of the glue roller is not blocked, the pressure detected by the pressure sensor T3 is relatively small, and the voltage signal output from its 3rd pin is relatively small. The voltage signal is divided by the adjustable resistor RP and the resistor R1, and the resistor R2 is reduced and limited to enter the base of the transistor Q1 below 0.7V. The transistors Q1 and Q2 will not be turned on, and the time relay module T4 will not input the positive control signal, so its 5th pin will not output power, and the subsequent motor reduction mechanism M and motor reduction mechanism AM1 will continue to be powered and work. When the glue hole of the glue roller is blocked (the amount of liquid outflow in the glue roller is reduced, and the compressed air input by the air compressor will cause the internal pressure to increase), the pressure detected by the pressure sensor T3 is relatively large, and the voltage signal output from its 3rd pin is relatively high. The voltage signal is divided by the adjustable resistor RP and the resistor R1, and the resistor R2 is reduced and limited to enter the base of the transistor Q1 above 0.7V. The transistor Q1 will turn on the collector to output a low level and enter the base of the transistor Q2. The transistor Q2 will turn on the collector to output a high level and enter the The positive pole of the time relay module T4 controls the signal input terminal 3, and the 5th pin of the time relay module T4 will output a 10-second power supply (the time is adjustable) to enter the power input terminals of relays J1, J2, solenoid valve DC, time-controlled switches T5 and T6. The solenoid valve DC is energized and the valve core is closed, and the glue temporarily stops entering the glue coating roller. Relays J1 and J2 are energized and their control power input terminals and normally closed contact terminals are open. Then, the motor reduction mechanism M and the motor reduction mechanism AM1 will temporarily lose power and stop working. After the time switch T5 is energized and works, its 3rd and 4th pins will first output power for 5 seconds to enter the positive and negative power input terminals of the two sets of electric push rods M2, and the push columns of the two sets of electric push rods M2 will push the multiple unblocking needles 83 downward, and the multiple metal unblocking needles 83 move downward to unblock the multiple glue holes 41 at the lower end of the glue coating roller from top to bottom; after the time switch T6 is energized and works, its 3rd and 4th pins will output power for 5 seconds to enter the negative and positive power input terminals of the two sets of electric push rods M2, and the push columns of the two sets of electric push rods M2 will drive the multiple unblocking needles 83 upward, and the multiple metal unblocking needles 83 move upward and are separated from the multiple glue holes 41 at the lower end of the glue coating roller, so that the medicine in the glue coating roller will be output to the transdermal patch through the multiple glue holes 41. After 10 seconds, the 3rd pin of the time relay module T4 stops outputting power, the relays J1 and J2 lose power and do not attract, and their control power input terminals and normally closed contact terminals are closed, the motor reduction mechanism M and the motor reduction mechanism AM1 will be powered on again, the solenoid valve DC loses power and the valve core opens, and the transdermal patch will be restored to normal and continuously apply the drug. After the transdermal patch on the subsequent feeding roller 14 is unwound, a new feeding roller 14 is replaced, and then the bolts fixing the motor reduction mechanism AM1 and the winding drum connecting plate are removed, and the new winding drum 142 is fixed to carry out the winding operation.Through the above, when the glue hole of the glue coating roller is clogged, the pressure sensor detects it and, under the action of the detection circuit and the trigger circuit, can promptly shut down the power supply of the relevant equipment, and automatically dredge the reaming hole through the control circuit and the dredging mechanism, thereby ensuring the uniform coating of the viscous agent as much as possible, improving the quality of the production of the transdermal patch, and correspondingly bringing convenience to the staff and improving work efficiency.

[0024] The above content illustrates the basic principle and main features of the present invention and the advantages of the present invention. It is obvious to those skilled in the art that the present invention is limited to the details of the above exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or basic features of the present invention. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims are included in the present invention.

[0025] In addition, it should be understood that although the present specification is described according to the implementation mode, the implementation mode does not only include an independent technical solution. This narrative method of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in the embodiments can also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A drug applicator for transdermal patch production, comprising a workbench, a roll-unwinding seat, an electric roll-up mechanism, an electric heating drying box, a glue-coating roller, a guide roller, a scraper roller, a guide seat, a pressure sensor, and a motor speed reduction mechanism, characterized in that: The invention also has a dredging mechanism, a control circuit, a detection circuit, and a trigger circuit; there are at least two unwinding seats, the upper ends of the two unwinding seats are provided with support holes, the lower ends of the two unwinding seats are respectively installed at the upper front part of the workbench, and the guide roller is installed at the rear end of the unwinding seat; there are multiple guide seats, each of which has a special-shaped guide hole, wherein the lower end of one guide seat is installed at one end of the rear side of the guide roller, and the lower ends of the other two guide seats are installed at a distance from each other at the other end of the rear side of the guide roller; special-shaped connecting pipes are respectively installed at both side ends of the glue coating roller, and the connecting pipes at both side ends of the glue coating roller are respectively slidably sleeved in the guide holes of the multiple guide seats, one end of the connecting pipe and the air inlet pipe of the pressure sensor are installed together, and the other end of the connecting pipe and the liquid outlet end of an electromagnetic valve are installed together and connected, the liquid inlet end of the electromagnetic valve and the liquid outlet pipe at the lower end of the medicine box are connected through a hose, the connecting pipe at the other end of the glue coating roller is located at the guide seat, the outer side of the connecting pipe is covered with a spring, and the outer side of the other end of the connecting pipe is installed with a top plate, and a motor reducer The structure is installed at the rear end of the top plate, and an eccentric wheel is installed at the front end of the rotating shaft of the motor reduction mechanism; the scraper roller, the electric heating drying box, and the electric winding mechanism are installed in sequence at the rear end of the glue coating roller at a front-to-back distance; the dredging mechanism includes an electric push rod, a connecting plate, and a dredging needle. The upper end of the glue coating roller has an opening, the cylinder of the electric push rod is installed outside the opening of the glue coating roller, and the push column of the electric push rod is located inside the glue coating roller, the connecting plate is transversely installed at the lower end of the push column of the electric push rod, and the upper ends of multiple dredging needles are respectively installed at the lower end of the connecting plate at a distance; the control circuit, the detection circuit, and the trigger circuit are installed in the electric control box, the power output end of the trigger circuit is electrically connected to the power input end of the control circuit, and the power output end of the control circuit is electrically connected to the power input end of the electric push rod; the signal output end of the detection circuit is electrically connected to the signal input end of the trigger circuit, and the control power output end of the trigger circuit is electrically connected to the power input end of the motor reduction mechanism M, the motor reduction mechanism A, and the electromagnetic valve.

2. The drug applicator for use in the production of a transdermal patch according to claim 1, characterized in that: The number of dredging needles is consistent with the number of glue holes on the glue coating roller.

3. The drug applicator for use in the production of a transdermal patch according to claim 1, characterized in that: The lower ends of the plurality of dredging needles and the middle parts of the upper ends of the plurality of glue holes are respectively located in a vertical plane, and the lower ends of the dredging needles are pointed cone-shaped, and the outer diameter of the lower ends of the dredging needles is smaller than the outer diameter of the glue holes.

4. The drug applicator for use in the production of a transdermal patch according to claim 1, characterized in that: The distance between the lower end of the electric heating drying box, the scraper roller and the guide roller, the lower end of the glue coating roller and the upper end of the workbench.

5. The drug applicator for use in the production of a transdermal patch according to claim 1, characterized in that: The convex surface of the eccentric wheel is in contact with the top plate.

6. The drug applicator for use in the production of a transdermal patch according to claim 1, characterized in that: The electric winding mechanism includes a motor speed reduction mechanism A and a fixed plate. The middle parts of the upper ends of the two fixed plates are respectively provided with support holes. The motor speed reduction mechanism A is installed on the rear end of the workbench. The side ends of the rotating shaft of the motor speed reduction mechanism A and the side ends of the transdermal patch winding drum are respectively provided with connecting plates, and the connecting plates have multiple fixing holes.

7. The drug applicator for use in the production of a transdermal patch according to claim 1, characterized in that: The control circuit comprises two sets of time-controlled switches which are electrically connected, and the power input ends of the two sets of time-controlled switches are connected respectively.

8. The drug applicator for use in the production of a transdermal patch according to claim 1, characterized in that: The trigger circuit includes an electrically connected time relay module, a power switch and a relay, one of the two relays is connected to a control power input terminal, the other control power input terminal of the two relays is connected to one end of the two power switches, the other ends of the two power switches are connected, the power output terminal of the time relay module is connected to the positive power input terminals of the two relays, and the negative power input terminals of the two relays are connected to the negative power input terminal of the time relay module and the negative control power input terminal.

9. The drug applicator for use in the production of a transdermal patch according to claim 1, characterized in that: The detection circuit includes an electrically connected adjustable resistor, a resistor, and a transistor. One end of the adjustable resistor is connected to one end of the first resistor and one end of the second resistor. The other end of the second resistor is connected to the base of the first transistor. The collector of the first transistor is connected to the base of the second transistor. The other end of the first resistor is connected to the emitter of the first transistor.

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