Excrement and urine sample collecting device for radioactive substance recovery

Abstract

The invention relates to an excrement and urine sample collecting device for radioactive substance recovery. The excrement and urine sample collecting device comprises a metabolism cage, a support, a collecting disc and a shielding cover. A feeder, a water feeding opening and a water feeding bottle hanging ring are arranged on the metabolism cage body, and the water feeding opening adopts a rectangular steel plate and is provided with an inclined hole, so that a water feeding bottle can be inserted into the water feeding opening through the inclined hole. The support is of a hollow structure, the collecting disc is of a disc-shaped structure, the metabolism cage, the support and the collecting disc are detachably connected through clamping grooves, and excrement and urine samples sequentially pass through the metabolism cage and the support and finally enter the collecting disc to be collected. The shielding cover covers the metabolism cage, the support and the collecting disc, radiation shielding protection is provided, and the safety of operators is ensured. Through reasonable design, the recovery rate of radioactive substances is improved, the assembling and cleaning processes of the device are simplified, sample pollution is avoided, effective radiation protection is provided, experiment safety is ensured, and meanwhile the working efficiency of testers is improved.

Description

Technical Field

[0001] The invention relates to the field of non-clinical research in radioactive medicine, and in particular to a feces and urine sample collecting device for recovering radioactive substances. Background Art

[0002] Experimental mouse metabolic cages are commonly used equipment in animal experiments. They are mainly used to control and collect metabolites in animals and are widely used in metabolic rate measurements of mice or rats and drug metabolism assessments. Through the collected feces and urine samples, researchers can conduct experiments such as intestinal flora analysis and urine routine tests. Metabolic cages have important application value in endocrine metabolic systems and medical drug toxicity tests. However, the currently available metabolic cages have the following deficiencies in the study of radioactive drug excretion and material balance:

[0003] Inconvenient disassembly and assembly: The existing metabolic cages are not convenient to disassemble and assemble, which affects the timely collection of urine and feces samples by experimenters and interferes with the timeliness of the samples.

[0004] Radioactive material attachment problem: During the collection process, radioactive materials in urine and feces are easily attached to the collection device of the metabolic cage, thereby affecting the accuracy of sample quantitative analysis and causing deviations in research results.

[0005] Radioactive contamination problem: Due to the presence of radioactive substances, traditional metabolic cages are easily contaminated, resulting in low equipment utilization efficiency. Radioactive contamination not only affects the long-term use of metabolic cages, but also has an adverse effect on the experimental cycle and the reuse of equipment.

[0006] Lack of shielding: Existing metabolic cages lack radiation shielding, which may pose potential harmful radiation risks to experimenters and the environment in radiopharmaceutical research.

[0007] Therefore, existing metabolic cages have problems such as inconvenient operation, poor pollution control and insufficient safety, and are in urgent need of improvement to increase the recovery rate of radioactive materials, reduce pollution, and ensure the safety of the experimental environment and personnel.

[0008] In view of the above problems, the present invention is proposed. Summary of the invention

[0009] The invention discloses a feces and urine sample collecting device for recovering radioactive substances, aiming to solve the technical problems existing in the prior art.

[0010] The present invention provides a feces and urine sample collection device for radioactive material recovery, comprising a metabolic cage, a bracket, a collection plate and a shielding cover;

[0011] The metabolic cage comprises a metabolic cage body, a feeder, a water feeding port and a water bottle hanging ring, wherein the feeder, the water feeding port and the water bottle hanging ring are arranged on the metabolic cage body, the water feeding port adopts a rectangular steel plate, an oblique hole is arranged on the steel plate, and the water bottle hanging ring is arranged opposite to the oblique hole, so that the water bottle can be inserted into the water feeding port through the oblique hole;

[0012] The bracket is designed as a hollow structure;

[0013] The collecting tray is designed as a tray-shaped structure;

[0014] The metabolic cage, the bracket and the collection tray are connected in sequence along the vertical direction. The bracket and the collection tray are both provided with slots for detachable connection between the metabolic cage and the bracket, and between the bracket and the collection tray. The feces and urine samples pass through the metabolic cage and the bracket in sequence and are collected in the collection tray. The shielding cover covers the outer sides of the metabolic cage, the bracket and the collection tray to isolate them from the outside world for radiation shielding protection.

[0015] As a preferred technical solution, a cling film and absorbent paper are sequentially arranged on the collection tray, and the cling film is in direct contact with the collection tray.

[0016] As a preferred technical solution, the collecting plate is made of polytetrafluoroethylene.

[0017] As a preferred technical solution, the shielding cover is made of lead-clad steel.

[0018] As a preferred technical solution, the metabolic cage body is a three-dimensional grid structure.

[0019] As a preferred technical solution, a metabolic cage door is also provided on the metabolic cage body, and buckles are respectively provided on the metabolic cage door and the metabolic cage body adjacent to the metabolic cage door for fixing the metabolic cage door.

[0020] As a preferred technical solution, the bracket includes at least one first handle for grasping; the shielding cover includes at least one second handle for grasping and lifting.

[0021] The technical solution adopted by the present invention can achieve at least one of the following beneficial effects:

[0022] 1. The present invention realizes efficient collection of feces and urine samples of experimental animals through the reasonable design and combination of metabolic cages, brackets and collection trays, avoids mixing or loss of samples during the collection process, and significantly improves the recovery rate of radioactive substances.

[0023] 2. The present invention adopts a card slot type detachable design, which makes the assembly, disassembly and cleaning of the device more convenient, greatly improves the operating efficiency of the experimenters, and saves time for experimental preparation and maintenance.

[0024] 3. In the present invention, a plastic wrap is first laid on the collection tray to isolate the sample from direct contact with the collection tray, and then absorbent paper is laid to collect the urine sample, thereby effectively avoiding the contamination of the collection tray by radioactive substances and ensuring the long-term performance of the device.

[0025] 4. The shielding cover of the present invention is made of steel-clad lead material to isolate the device from the outside world, provide excellent radiation shielding performance, effectively reduce the radiation impact of radioactive substances on the experimental environment and operators, and ensure the safety of the experiment. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for describing the embodiments, which constitute a part of the present invention. The exemplary embodiments of the present invention and their descriptions explain the present invention and do not constitute improper limitations on the present invention. In the drawings:

[0027] Figure 1 It is a three-dimensional schematic diagram of a feces and urine sample collection device for radioactive material recovery of the present invention;

[0028] Figure 2 It is a schematic diagram of the structure of the metabolic cage of the present invention;

[0029] Figure 3 It is a schematic diagram of the structure of the support of the present invention;

[0030] Figure 4 It is a schematic structural diagram of the collecting plate of the present invention;

[0031] Figure 5 It is a schematic structural diagram of the shielding cover of the present invention.

[0032] Description of reference numerals:

[0033] 1. Metabolic cage; 11. Metabolic cage body; 12. Metabolic cage door; 13. Feeder; 14. Water inlet; 15. Water bottle hanging ring; 16. Handle; 17. Buckle; 2. Bracket; 21. Bracket body; 22. First handle; 3. Collection tray; 4. Shielding cover; 41. Shielding cover body; 42. Second handle. DETAILED DESCRIPTION

[0034] In order to make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be clearly and completely described below in conjunction with the specific embodiments of the present invention and the corresponding drawings. In the description of the present invention, it should be noted that the term "or" is usually used in the sense of including "and / or", unless the content clearly indicates otherwise.

[0035] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected" and "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or a magnetic connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be internal communication between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances. In addition, in the description of this application, the terms "first", "second", etc. are only used to distinguish the description and cannot be understood as indicating or implying relative importance.

[0036] Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0037] In order to solve the problems existing in the prior art, the embodiment of the present invention provides a feces and urine sample collection device for radioactive material recovery, and in particular relates to the collection of radioactive drug excretion samples of experimental animals, such as Figure 1-Figure 5 As shown, it includes a metabolic cage 1, a support 2, a collection plate 3 and a shielding cover 4. Figure 1 As shown, based on the direction in the use state, the metabolic cage 1, the bracket 2 and the collection tray 3 are connected in sequence, the metabolic cage 1 is located at the upper end, and the collection tray 3 is located at the bottom. The metabolic cage 1 is used to provide an activity space for the experimental animals to ensure that the activities of the experimental animals are minimally disturbed, while avoiding the mixing or contamination of metabolites; the bracket 2 is used to support, fix and protect the metabolic cage 1, and provide a stable platform for placing the metabolic cage 1 to prevent tilting or movement during the experiment, while avoiding external mechanical shock or improper operation to ensure the experimental environment; the collection tray 3 is used to collect liquid or solid metabolites produced by the experimental animals during the metabolic process, which is convenient for subsequent analysis and processing. The shielding cover 4 is arranged on the outside of the structure formed by the connection of the metabolic cage 1, the bracket 2 and the collection tray 3, and is used to shield the external environment and experimental operators from radiation damage.

[0038] like Figure 2As shown, the metabolic cage 1 is provided with a metabolic cage body 11, a metabolic cage door 12, a top handle 16 and a buckle 17. The metabolic cage body 11 is a three-dimensional grid structure, which is used to accommodate experimental animals, provide ventilation and observation conditions, and prevent the experimental animals from escaping; a metabolic cage door 12 is provided on the side of the metabolic cage body 11, which is used to provide an entry and exit channel for the experimental animals, and buckles 17 are respectively provided on the metabolic cage door 12 and the metabolic cage body 11 adjacent thereto, and the two buckles 17 are arranged on the same horizontal line, which are used to fix the metabolic cage door 12 on the metabolic cage body 11 to prevent the metabolic cage door 12 from being accidentally opened due to vibration or the activity of the experimental animals during the experiment, thereby ensuring the safety of the experimental animals; a handle 16 is provided on the top of the metabolic cage body 11 to facilitate the movement and transportation of the metabolic cage 1 while keeping the structure firm.

[0039] The metabolic cage 1 is also provided with a feeder 13, a water inlet 14 and a water bottle hanging ring 15. The feeder 13 is arranged on the metabolic cage door 12. Figure 1 and Figure 2 As shown, the feeder 13 is designed as a rectangular container structure for storing feed for experimental animals. The main body is made of durable, corrosion-resistant materials, such as stainless steel or high-strength plastic. An open or semi-open opening is provided on the upper portion of the feeder 13 to facilitate the experimenter to add feed. An inclined design is adopted between the bottom and the upper portion of the feeder 13 to facilitate the spillage of feed, ensuring that the experimental animals can eat conveniently. Preferably, the feeder 13 is detachably arranged on the metabolic cage door 12 to facilitate maintenance and cleaning after the experiment. The water inlet 14 is made of a rectangular steel plate with an inclined hole. The water bottle hanging ring 15 is arranged opposite to the water inlet 14. When the water bottle is hung, Figure 2 The direction shown is taken as the standard, the mouth of the water bottle is facing downward in the vertical direction, close to the metabolic cage body 11 and placed in an inverted manner, the water bottle hanging ring 15 is screwed upward in the vertical direction and clamps the water bottle, so that it is fixed between the water bottle hanging ring 15 and the metabolic cage body 11, and the mouth of the water bottle is inserted into the inclined hole of the water feeding port 14 to provide the experimental animals with the drinking water they need.

[0040] like Figure 3 As shown, the bracket 2 includes a bracket body 21 and at least one first handle 22 disposed on the bracket body 21. The first handle 22 is disposed on the side of the bracket body 21 to facilitate the timely replacement of the collection tray 3. Preferably, the number of the first handles 22 is 1-4. The bracket body 21 is a hollow structure.

[0041] like Figure 5As shown, the shielding cover 4 includes a shielding cover body 41 and at least one second handle 42 disposed on the shielding cover body 41. The second handle 42 is disposed on the side of the shielding cover body 41 to facilitate the experimenter to grab and lift the shielding cover 4. Preferably, the number of the second handles 42 is 1-4. The shielding cover 4 is used to cover the metabolic cage 1, the bracket 2 and the collection tray 3 to form a relatively closed environment. The collection tray 3 adopts a disc-shaped structure for collecting metabolite samples.

[0042] In the experimental state, the metabolic cage 1 is fixedly arranged above the bracket 2, and the collection tray 3 is fixedly arranged below the bracket 2. The bracket 2 has a slot for fixing the metabolic cage 1; the collection tray 3 also has a slot for fixing the bracket 2. Through the above-mentioned slot arrangement, the metabolic cage 1, the bracket 2 and the collection tray 3 form a detachable connection structure.

[0043] Through the above structural design, the metabolites in the metabolic cage 1 fall into the hollow bracket 2 through the grid structure, and continue to fall to the collection tray 3 for recovery. The coordinated cooperation of the metabolic cage 1, the bracket 2, and the collection tray 3 realizes the efficient recovery of the metabolites of experimental animals. At the same time, combined with the shielding cover 4, the safety of the experimental environment and the effective shielding of radioactive substances are ensured.

[0044] In some preferred embodiments, plastic wrap and absorbent paper are provided on the collection tray 3. The plastic wrap is placed close to the collection tray 3 and the absorbent paper is placed on top of the plastic wrap. The plastic wrap is used to protect the collection tray 3 to prevent the radioactive sample from directly contacting the collection tray 3 and causing radioactive contamination; the absorbent paper is used to collect urine samples.

[0045] In some preferred embodiments, the collecting tray 3 is made of polytetrafluoroethylene.

[0046] In some preferred embodiments, the shielding cover 4 is made of lead-clad steel.

[0047] In some preferred embodiments, the length, width and height of the metabolic cage 1 are all 20 cm.

[0048] In some preferred embodiments, the length, width and height of the bracket 2 are 30 cm, 20 cm and 15 cm respectively.

[0049] In some preferred embodiments, the length, width and height of the collecting tray 3 are 30 cm, 20 cm and 1 cm respectively.

[0050] In some preferred implementation schemes, the length, width and height of the shielding cover 4 are 40 cm, 30 cm and 40 cm respectively.

[0051] The embodiments of the present invention are described above in conjunction with the accompanying drawings, but the present invention is not limited to the above-mentioned specific implementation modes, which are merely illustrative rather than restrictive. Under the guidance of the present invention, ordinary technicians in this field can also make many forms without departing from the scope of protection of the present invention and the claims, all of which are within the protection of the present invention.

Claims

1. A feces and urine sample collection device for radioactive material recovery, characterized in that: Includes metabolic cage, stand, collection tray and shield; The metabolic cage comprises a metabolic cage body, a feeder, a water feeding port and a water bottle hanging ring, wherein the feeder, the water feeding port and the water bottle hanging ring are arranged on the metabolic cage body, the water feeding port adopts a rectangular steel plate, an oblique hole is arranged on the steel plate, and the water bottle hanging ring is arranged opposite to the oblique hole, so that the water bottle can be inserted into the water feeding port through the oblique hole; The bracket is designed to be a hollow structure; The collecting tray is designed as a tray-shaped structure; The metabolic cage, the bracket and the collection tray are connected in sequence along the vertical direction. The bracket and the collection tray are both provided with a card slot for detachable connection between the metabolic cage and the bracket, and between the bracket and the collection tray. The feces and urine samples pass through the metabolic cage and the bracket in sequence and are collected in the collection tray. The shielding cover covers the outer sides of the metabolic cage, the bracket and the collection tray to isolate them from the outside world for radiation shielding protection.

2. The feces and urine sample collection device according to claim 1, characterized in that: A preservative film and absorbent paper are arranged on the collection tray in sequence, and the preservative film is in direct contact with the collection tray.

3. The feces and urine sample collection device according to claim 2, characterized in that: The collecting plate is made of polytetrafluoroethylene.

4. The feces and urine sample collection device according to claim 1, characterized in that: The shielding cover is made of steel-clad lead.

5. The feces and urine sample collection device according to claim 1, characterized in that: The metabolic cage body is a three-dimensional grid structure.

6. The feces and urine sample collection device according to claim 5, characterized in that: The metabolic cage body is also provided with a metabolic cage door, and the metabolic cage door and the metabolic cage body adjacent to the metabolic cage door are respectively provided with buckles for fixing the metabolic cage door.

7. The feces and urine sample collection device according to any one of claims 1 to 6, characterized in that: The bracket includes at least one first handle for grasping; the shielding cover includes at least one second handle for grasping and lifting.

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