Accurate administration mouse asthma model test box for traditional Chinese medicine absorption

Abstract

The invention discloses an accurate administration mouse asthma model test box for traditional Chinese medicine absorption, and relates to the field of medical animal experiments.The accurate administration mouse asthma model test box comprises a box body, a box cover is connected to the top of the box body, a partition plate is fixed to the inner side of the box body, a rolling mechanism comprises an external connection block, the external connection block is fixed to the surface of a medicine tank, and a motor is installed in the external connection block; a rubber cam is fixed to the output end of the motor and located in the center of the medicine tank, the rubber cam is further located on the front surface of the ball, and the knocking ball is fixed to one end of the rotating rod. According to the mouse asthma model test box for accurately feeding the medicine and absorbing the traditional Chinese medicine, the balls can roll in the gallipot through friction force of licking, so that liquid medicine in the gallipot is continuously taken away, descending of the liquid medicine can be monitored by the liquid level sensor at any time, and accurate control over medicine feeding of the test box is achieved; the knocking ball knocks the inner wall of the fixed cylinder to make a sound to attract the attention of the laboratory mouse, so that the test efficiency can be accelerated.

Description

Technical Field

[0001] The invention relates to the technical field of animal experiments, and in particular to a mouse asthma model test box for traditional Chinese medicine absorption with precise drug administration. Background Art

[0002] Medical animal experiments refer to the use of animals as experimental subjects in medical research to test new drugs, study disease mechanisms, develop new treatments or verify research hypotheses. In order to treat childhood asthma, it is necessary to first conduct medical experiments on laboratory mice in a test chamber, that is, a mouse asthma model test chamber. This equipment injects drugs into the bodies of laboratory mice and observes the changes in the mice. The drugs are tested through a large number of experiments to ensure their safety and effectiveness.

[0003] At present, the mouse asthma model test box still has some shortcomings, such as each mouse fails to absorb the drug relatively evenly: In order to overcome the problem of uneven drug absorption, a Chinese patent of the prior art (publication number: CN216254593U) discloses a mouse asthma modeling device, wherein a partition divides a cavity into a plurality of equal-volume compartments, a plurality of air holes are provided on the surface of the partition, an inner plate covers the top of all the compartments, the compartments and the gas delivery device are interconnected through an air-permeable net, the experimenter puts a mouse in each compartment one by one, the partition separates the adjacent mice, each mouse moves in its own compartment, the air holes make the gas in the cavity more circulated, and each mouse inhales the atomized experimental drug solution relatively evenly, thereby ensuring the relative consistency of the final asthma model individuals, and at the same time, the present invention can simultaneously perform asthma modeling on a plurality of mice at a time, which has the advantages of saving time and convenience; In addition, a Chinese patent of the prior art (publication number: CN215458958U) discloses a test box for constructing a mouse asthma model, which is provided with a slider and a rod. When the rod is pulled, the rod drives the slider to move, thereby driving the atomizing spray box to move. The liquid medicine in the atomizing spray box is evenly delivered into the test box through the nozzle, thereby increasing the propagation speed of the liquid medicine. By providing a metal reed, the slider will make a sound when it hits the metal reed, thereby scaring the mouse, thereby increasing the mouse's breathing frequency, increasing the amount of medicine inhaled by the mouse, and accelerating the experimental efficiency.

[0004] However, the mouse asthma model test box currently used still has certain shortcomings. In the above-mentioned document, the drug absorption is relatively uniform through other circulations, and Chinese medicine can be fed into the body of the experimental mouse by feeding the drug solution, but the experimental mouse is difficult to cooperate with the test, which will affect the efficiency of the test. Secondly, the amount of drug is difficult to control and accurate experimental data cannot be obtained. Therefore, it is necessary to improve the existing structure. Summary of the invention

[0005] The purpose of the present invention is to provide a mouse asthma model test box for Chinese medicine absorption with precise drug administration, so as to solve the problems mentioned in the above background technology that it is inconvenient to feed medicine to experimental mice, the dosage is difficult to control, and the experimental mice cannot quickly detect the outflow of medicine solution, which affects the efficiency of feeding medicine.

[0006] To achieve the above object, the present invention provides the following technical solution: a mouse asthma model test box for traditional Chinese medicine absorption with precise drug administration, comprising a box body, a box cover connected to the top of the box body, and a partition plate fixed inside the box body: The side of the partition plate is connected to a fixing frame, a medicine tank is installed inside the fixing frame, a liquid level sensor is installed on the side of the partition plate close to the fixing frame, a connecting line at the bottom of the liquid level sensor is connected to the inside of the medicine tank, a ball is connected to the medicine outlet at the bottom of the medicine tank, and a rolling mechanism is provided on the side of the partition plate to improve the accuracy of drug administration to experimental mice; A fixed cylinder is fixed on the side of the medicine tank, and a rotating rod is rotatably connected to the side of the medicine tank close to the fixed cylinder. The rotating rod penetrates and moves inside the fixed cylinder, and a knocking mechanism for attracting experimental mice is arranged on the side of the medicine tank; The partition plate is symmetrically provided with guide grooves on its side near the fixing frame, a guide block is slidably passed through the guide groove, and the guide block is fixed to the end of the fixing frame. An adjustment mechanism is also provided inside the partition plate to improve the adaptability to the specifications of experimental mice.

[0007] Furthermore, the rolling mechanism includes an external block, which is fixed on the surface of the medicine tank. A motor is installed inside the external block, and a rubber cam is fixed to the output end of the motor. The rubber cam is located at the center of the medicine tank, and the rubber cam is also located on the front surface of the ball.

[0008] Furthermore, the knocking mechanism includes a knocking ball, which is fixed to one end of a rotating rod. A rotating rod is inserted and rotated inside the medicine tank, and the rotating rod is fixed to a side of the rubber cam away from the motor.

[0009] Furthermore, a large gear is fixed to the end of the rotating rod away from the rubber cam, and a small gear is meshed and connected to the side of the large gear, and the small gear rotates on the side of the medicine tank close to the rotating rod.

[0010] Furthermore, a rotating block is fixed on the side of the small gear away from the medicine tank, and the rotating block, the small gear, the large gear, the rotating rod and the rubber cam are in transmission connection.

[0011] Furthermore, the side of the rotating block away from the pinion is rotatably connected with a connecting block, and a fixing rod is fixed on the top of the connecting block. The fixing rod penetrates and slides on the inner side of the end of the rotating rod away from the striking ball.

[0012] Furthermore, the adjustment mechanism includes a snap-fitting groove, which is provided on a side of the partition plate close to the guide groove, and is located between two guide grooves, and a plurality of snap-fitting grooves are provided.

[0013] Furthermore, a fixing block is fixed on the inner side of the fixing frame, and a telescopic slot is formed through the top of the fixing block.

[0014] Furthermore, a locking block is slidably arranged inside the telescopic slot, and a spring is connected between the locking block and the telescopic slot. The locking block forms a telescopic structure with the telescopic slot through the spring, and a push block is fixed on the top of the locking block.

[0015] Furthermore, the push block also penetrates and slides inside the telescopic slot, and the engaging block is engaged with the engaging slot.

[0016] Compared with the prior art, the present invention has the following beneficial effects: 1. The mouse asthma model test box for the precise drug delivery of traditional Chinese medicine absorption uses a ball rolling inside the medicine tank through the friction of licking, thereby continuously taking away the liquid medicine inside the medicine tank. The drop of the liquid medicine can be monitored by the liquid level sensor at all times, realizing the precise control of drug feeding in the test box. The knocking ball knocks on the inner wall of the fixed cylinder to make a sound, attracting the attention of the experimental mice, which can speed up the efficiency of the test; 2. A liquid level sensor is provided, through which the position of the liquid in the medicine tank can be monitored, so that the amount of medicine fed to the experimental mice can be accurately known, improving the precise control of medicine feeding; 3. A rubber cam is provided, through which the ball can be controlled, and the amount of medicine fed to the experimental mice and the time of feeding medicine can be selectively controlled, which improves the convenience of the experiment; 4. A knocking ball is provided, which can knock on the inner wall of the fixed cylinder. The sound produced by the knocking will attract the attention of the experimental mice, so that the experimental mice will be attracted by the smell of the medicine liquid, which speeds up the efficiency of feeding medicine; 5. A guide block is provided, and the height of the medicine tank can be adjusted by sliding the guide block and the guide groove, so that the height of the medicine tank can be adjusted according to the size of the experimental mouse, thereby making it convenient for the experimental mouse to take medicine and improving the adaptability of the test box to the experimental mouse. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the overall front-view stereoscopic structure of the present invention; Figure 2 It is a schematic diagram of the enlarged three-dimensional structure of the box body of the present invention; Figure 3 This is an enlarged three-dimensional structural schematic diagram of the medicine tank of the present invention; Figure 4 This is a schematic diagram of an enlarged three-dimensional structure of a ball bearing according to the present invention; Figure 5 It is an enlarged three-dimensional structural schematic diagram of the rubber cam of the present invention; Figure 6 It is an enlarged three-dimensional structural schematic diagram of the fixing tube of the present invention; Figure 7 It is a schematic diagram of an enlarged three-dimensional structure of the rotating rod of the present invention; Figure 8 It is an enlarged three-dimensional structural schematic diagram of the fixing rod of the present invention; Fig. 9 It is a schematic diagram of an enlarged three-dimensional structure of the fixing frame of the present invention; Fig.10 It is a schematic diagram of the three-dimensional structure of the fixed block of the present invention in cross-section.

[0018] In the figure: 1. box body; 2. box cover; 3. partition plate; 301. fixing frame; 302. medicine tank; 303. liquid level sensor; 305. ball; 306. external block; 307. rubber cam; 308. fixing cylinder; 309. rotating rod; 310. knocking ball; 311. rotating rod; 312. large gear; 313. small gear; 314. rotating block; 315. connecting block; 316. guide groove; 317. guide block; 318. engaging groove; 319. fixing block; 320. telescopic groove; 321. engaging block; 322. pushing block; 323. fixing rod. DETAILED DESCRIPTION

[0019] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0020] Embodiment 1: Figure 1-Figure 5The technical scheme shown in the figure, the present invention provides the following technical scheme: in order to solve the problem that it is inconvenient to feed medicine to experimental mice and the dosage is difficult to control, a rolling mechanism is disclosed: it includes a box body 1, a box cover 2 is connected to the top of the box body 1, and a partition plate 3 is fixed on the inner side of the box body 1: a fixing frame 301 is connected to the side of the partition plate 3, a medicine tank 302 is installed inside the fixing frame 301, a liquid level sensor 303 is installed on the side of the partition plate 3 close to the fixing frame 301, a connecting line at the bottom of the liquid level sensor 303 is connected to the inside of the medicine tank 302, a ball 305 is connected to the inside of the medicine outlet at the bottom of the medicine tank 302, and a rolling mechanism for improving the accuracy of drug administration for experimental mice is arranged on the side of the partition plate 3; a fixing cylinder 308 is fixed to the side of the medicine tank 302, and the medicine tank 302 is close to the fixing cylinder 308. 08 is rotatably connected to the side with a rotating rod 309, and the rotating rod 309 penetrates and moves inside the fixed cylinder 308. A knocking mechanism for attracting experimental mice is arranged on the side of the medicine tank 302. A guide groove 316 is symmetrically opened on the side of the partition plate 3 close to the fixed frame 301. A guide block 317 slides through the guide groove 316. The guide block 317 is fixed to the end of the fixed frame 301. An adjustment mechanism for improving the adaptability to the specifications of experimental mice is also arranged inside the partition plate 3. The rolling mechanism includes an external block 306, which is fixed on the surface of the medicine tank 302. A motor is installed inside the external block 306. A rubber cam 307 is fixed on the output end of the motor. The rubber cam 307 is located at the center of the medicine tank 302, and the rubber cam 307 is also located on the positive surface of the ball 305. When the test device is used, the experimental mice are placed in the grid formed by the box 1 and the partition plate 3. The experimental mice in each grid do not disturb each other. The guide that the experimental mice like needs to be added to the medicine required by the experimental mice, so that the experimental mice will be attracted. When it is necessary to feed the medicine to the experimental mice, the motor is started, and the output end of the motor can drive the rubber cam 307 to rotate. When the rubber cam 307 rotates, the protruding part can be rotated to the surface of the ball 305 for extrusion and friction. The rubber cam 307 will be deformed to a certain extent in this process. At the same time, the rubber cam 307 can drive the ball 305 to roll. When the ball 305 rolls, it can roll through the liquid outlet of the medicine tank 302. A part of the liquid outlet is in contact with the medicine, and the other part is exposed to the inside of the medicine tank 302. When the part with the medicine rotates with the ball 305 After exiting the medicine tank 302, the rubber cam 307 stops rotating, and the protruding portion of the rubber cam 307 does not contact the ball 305. The smell of the medicine will attract the lab mice, and the attracted lab mice will lick the ball 305. The licking will generate friction, and the ball 305 will continue to roll inside the medicine tank 302 through the friction of the licking. The continuous rolling of the ball 305 will cause the amount of liquid medicine inside the medicine tank 302 to become less and less, and the decrease of the liquid medicine can be monitored at all times by the liquid level sensor 303. When the amount of medicine reaches the specified value, the rubber cam 307 can be rotated back to the surface of the ball 305 for positioning. After the ball 305 is positioned, the liquid medicine will not flow out, and the lab mice will not continue to lick it, thereby achieving precise control of drug feeding in the test box and improving the accuracy of the test.

[0021] Embodiment 2: Figure 4-Figure 8The technical solution shown in the figure, the present invention provides the following technical solution: in order to solve the problem that the experimental mice cannot quickly find the outflow of the medicine solution, which affects the feeding efficiency, on the basis of the first embodiment, a knocking mechanism is disclosed: the knocking mechanism includes a knocking ball 310, the knocking ball 310 is fixed to one end of the rotating rod 309, a rotating rod 311 is rotated through the inside of the medicine tank 302, and the rotating rod 311 is fixed to the side of the rubber cam 307 away from the motor, and a large gear 312 is fixed to the end of the rotating rod 311 away from the rubber cam 307, and a small gear 313 is meshed and connected to the side of the large gear 312, and the small gear 313 rotates on the side of the medicine tank 302 close to the rotating rod 309. The small gear 313 is fixed with a rotating block 314 on the side away from the medicine tank 302. The rotating block 314, the small gear 313, the large gear 312, the rotating rod 311 and the rubber cam 307 are transmission connected. The rotating block 314 is rotatably connected with a connecting block 315 on the side away from the small gear 313. A fixing rod 323 is fixed on the top of the connecting block 315. The fixing rod 323 penetrates and slides on the inner side of the end of the rotating rod 309 away from the knocking ball 310. When the experimental mice are fed with medicine, the motor can drive the rubber cam 307 to rotate, so that the ball 305 brings the medicine liquid out of the medicine tank 302. The rubber cam 307 can drive the rotating rod while bringing out the medicine liquid. 311 rotates, when the rotating rod 311 rotates, it can drive the large gear 312 to rotate, when the large gear 312 rotates, it can drive the small gear 313 to mesh and rotate, when the small gear 313 meshes and rotates, it can rotate through the surface of the medicine tank 302, when the small gear 313 rotates, it can drive the rotating block 314 to rotate, when the rotating block 314 rotates, it can drive the connecting block 315 to rotate, when the connecting block 315 rotates, it can drive the fixed rod 323 to rotate, when the fixed rod 323 rotates, it can squeeze the rotating rod 309, when the rotating rod 309 is squeezed, it can rotate through the medicine tank 302, when the rotating rod 309 rotates, it can drive the knocking ball 310 to rotate During the movement, the connecting block 315 can be rotated by the rotating block 314, the fixed rod 323 can slide through the inside of the rotating rod 309, and the knocking ball 310 can knock when it rotates to the inner wall of the fixed cylinder 308. Due to the different gear ratios, the large gear 312 will drive the rotating block 314 to rotate several circles, and the rotating block 314 that rotates several circles will drive the knocking ball 310 to knock on the inner wall of the fixed cylinder 308 for many times. The fixed cylinder 308 will make a sound after being knocked, so as to attract the attention of the experimental mouse, so that the experimental mouse can quickly approach the ball 305, and can observe the medicine on the surface of the ball 305 more quickly and swallow it, thereby speeding up the efficiency of the experiment.

[0022] Embodiment 3: Figure 3 , Fig. 9 and Fig.10 The technical solution shown in the figure, the present invention provides the following technical solution: In order to solve the problem that the experimental mice are different in specifications and it is difficult to feed medicine, on the basis of the first embodiment, an adjustment mechanism is disclosed: The adjustment mechanism includes a snap-fitting groove 318, which is arranged on the side of the partition plate 3 close to the guide groove 316, and the snap-fitting groove 318 is located between the two guide grooves 316, and a plurality of snap-fitting grooves 318 are arranged. A fixing block 319 is fixed on the inner side of the fixing frame 301, and a telescopic groove 320 is arranged on the top of the fixing block 319. Due to the different sizes of experimental mice, in order to facilitate the position of the medicine jar 302 not being too high or too low to affect the feeding of the experimental mice, the pushing block 322 can be pushed to drive the snap-fitting block 321 to move, and the pushing block 322 can slide through the telescopic groove 320 when moving, and the snap-fitting block 321 can slide through the snap-fitting groove 318 and the telescopic groove 320 when moving, and the spring inside the telescopic groove 320 can be squeezed when the snap-fitting block 321 slides. After pressing out the locking groove 318, the fixed frame 301 is pushed down. When the fixed frame 301 is pushed down, the guide block 317 can be driven to move. When the guide block 317 moves, it can slide through the two guide grooves 316. When the guide block 317 slides, the fixed frame 301 can drive the medicine jar 302 to move downward. When the medicine jar 302 moves down to the specified position, the fixed block 319 can drive the locking block 321 to move to the other side of the locking groove 318. At this time, the push block 322 is released and it can be reset by the elastic force of the spring itself. When the push block 322 is reset, it can drive the locking block 321 to reset. When the locking block 321 is reset, it can be inserted into another locking groove 318 for locking and positioning. After the locking block 321 is positioned, the height of the medicine jar 302 can be adjusted, thereby making it convenient for experimental mice to take medicine and improving the practicality of the test box.

[0023] Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments, or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A mouse asthma model test box for traditional Chinese medicine absorption with precise drug delivery, comprising a box body (1), a box cover (2) connected to the top of the box body (1), and a partition plate (3) fixed inside the box body (1), characterized in that: The side of the partition plate (3) is connected to a fixing frame (301), a medicine tank (302) is installed inside the fixing frame (301), a liquid level sensor (303) is installed on the side of the partition plate (3) close to the fixing frame (301), a connecting line at the bottom of the liquid level sensor (303) is connected to the inside of the medicine tank (302), a ball (305) is embedded and rollingly connected inside the medicine outlet at the bottom of the medicine tank (302), and a rolling mechanism is arranged on the side of the partition plate (3) to improve the accuracy of drug administration to experimental mice; A fixed cylinder (308) is fixed on the side of the medicine tank (302); a rotating rod (309) is rotatably connected to the side of the medicine tank (302) close to the fixed cylinder (308); the rotating rod (309) penetrates and moves inside the fixed cylinder (308); and a knocking mechanism for attracting experimental mice is arranged on the side of the medicine tank (302); The partition plate (3) is symmetrically provided with guide grooves (316) on the side surface close to the fixing frame (301), a guide block (317) is slidably passed through the guide groove (316), and the guide block (317) is fixed to the end of the fixing frame (301). The partition plate (3) is also provided with an adjustment mechanism to improve the adaptability to the specifications of experimental mice.

2. The mouse asthma model test box for traditional Chinese medicine absorption with precise drug delivery according to claim 1, characterized in that: The rolling mechanism comprises an external block (306), the external block (306) being fixed on the surface of the medicine tank (302), a motor being installed inside the external block (306), a rubber cam (307) being fixed to the output end of the motor, the rubber cam (307) being located at the center of the medicine tank (302), and the rubber cam (307) being also located on the front surface of the ball (305).

3. The mouse asthma model test box for traditional Chinese medicine absorption with precise drug delivery according to claim 1, characterized in that: The knocking mechanism comprises a knocking ball (310), the knocking ball (310) being fixed to one end of a rotating rod (309), a rotating rod (311) passing through the inside of the medicine tank (302) for rotation, and the rotating rod (311) being fixed to a side of the rubber cam (307) away from the motor.

4. The mouse asthma model test box for traditional Chinese medicine absorption with precise drug delivery according to claim 3, characterized in that: A large gear (312) is fixed to the end of the rotating rod (311) away from the rubber cam (307), and a small gear (313) is meshedly connected to the side of the large gear (312). The small gear (313) rotates on the side of the medicine tank (302) close to the rotating rod (309).

5. The mouse asthma model test box for traditional Chinese medicine absorption with precise drug delivery according to claim 4, characterized in that: A rotating block (314) is fixed to the side of the small gear (313) away from the medicine tank (302), and the rotating block (314), the small gear (313), the large gear (312), the rotating rod (311) and the rubber cam (307) are in transmission connection.

6. The mouse asthma model test box for traditional Chinese medicine absorption with precise drug delivery according to claim 5, characterized in that: The side of the rotating block (314) away from the pinion (313) is rotatably connected to a connecting block (315), and a fixing rod (323) is fixed on the top of the connecting block (315). The fixing rod (323) penetrates and slides on the inner side of the end of the rotating rod (309) away from the striking ball (310).

7. The mouse asthma model test box for traditional Chinese medicine absorption with precise drug delivery according to claim 1, characterized in that: The adjustment mechanism comprises a snap-fit ​​groove (318), the snap-fit ​​groove (318) being provided on a side of the partition plate (3) close to the guide groove (316), the snap-fit ​​groove (318) being located between two guide grooves (316), and a plurality of snap-fit ​​grooves (318) being provided.

8. The mouse asthma model test box for traditional Chinese medicine absorption with precise drug delivery according to claim 1, characterized in that: A fixing block (319) is fixed inside the fixing frame (301), and a telescopic slot (320) is formed through the top of the fixing block (319).

9. The mouse asthma model test box for traditional Chinese medicine absorption with precise drug delivery according to claim 8, characterized in that: A locking block (321) is slidably disposed inside the telescopic slot (320), and a spring is connected between the locking block (321) and the telescopic slot (320). The locking block (321) and the telescopic slot (320) form a telescopic structure via the spring, and a push block (322) is fixed to the top of the locking block (321).

10. The mouse asthma model test box for traditional Chinese medicine absorption with precise drug delivery according to claim 9, characterized in that: The pushing block (322) also penetrates and slides inside the telescopic slot (320), and the engaging block (321) is engaged with the engaging slot (318).

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