Bio-adhesive patch endoluminal delivery device and method of use

Abstract

The embodiment of the invention provides an alimentary canal intracavitary delivery device of a biological adhesive patch and a use method, the alimentary canal intracavitary delivery device of the biological adhesive patch can extend into a target position in a cavity of a patient through a delivery channel in a mechanical arm, and the alimentary canal intracavitary delivery device of the biological adhesive patch comprises a delivery pipe and a delivery pipe, the conveying pipe comprises a working end, and the working end can extend into a cavity of a patient; the biological adhesive patch is arranged at the working end of the conveying pipe, the surfaces of the two sides of the biological adhesive patch are provided with a first adhesive layer and a second adhesive layer respectively, the first adhesive layer adheres to the working end, and the second adhesive layer can adhere to a target position in a cavity of a patient. According to the alimentary canal intracavity delivery device of the biological adhesive patch, medicine is continuously supplied to an intracavity wound of a patient in a biological adhesive patch mode for a long time, and the number of times of supplying medicine to the interior of the cavity of the patient is reduced.

Description

Technical Field

[0001] The embodiments of the present application relate to the field of medical device technology, and more particularly to a digestive tract intraluminal delivery device and a method of using a bioadhesive patch. Background Art

[0002] In a medical environment, fistulas may occur in the patient's cavity due to various diseases (such as surgery, ulcers, etc.), and suppuration often occurs. There is currently no effective clinical treatment. If a robotic arm (such as a digestive endoscope, etc.) is inserted into the patient's cavity to directly deliver drugs to the lesion, the drug is in a free state and cannot be continuously targeted to the target area. If physical clamping is performed directly with a medical tissue clip, the wound cannot heal normally due to the presence of purulent components and the lack of effective drug treatment components in the tissue clip. In addition, when the diameter of the fistula is large, the tissue tension is large and it may be impossible to clamp it. At the same time, high tension is not conducive to wound healing. Therefore, it is necessary to provide patients with a medical device that can provide continuous drug treatment for a long time and can seal the wound with low tension to help the wound heal. Summary of the invention

[0003] In view of this, an embodiment of the present application provides a digestive tract intraluminal delivery device of a bioadhesive patch, which reduces the number of times the drug is supplied to the patient's cavity by continuously supplying the drug to the patient's intraluminal wound in the form of a bioadhesive patch for a long time.

[0004] According to the first aspect of the present application, a digestive tract intracavity delivery device of a bioadhesive patch is provided, and the digestive tract intracavity delivery device of the bioadhesive patch can be extended into a target position in the patient's cavity through a delivery channel inside a robotic arm, and the digestive tract intracavity delivery device of the bioadhesive patch comprises: a delivery tube, the delivery tube comprising a working end, and the working end can be extended into the patient's cavity; a bioadhesive patch, the bioadhesive patch is arranged to the working end of the delivery tube, and the two side surfaces of the bioadhesive patch respectively have a first adhesive layer and a second adhesive layer, the first adhesive layer is adhered to the working end, and the second adhesive layer can be adhered to the target position in the patient's cavity.

[0005] Optionally, the bioadhesive patch comprises a main body, one side surface of the main body has an adhesive area and a drug area, the drug area can be provided with a variety of medical drugs, and the adhesive area is an edible dissolving material.

[0006] Optionally, the viscosity of the first adhesive layer is lower than the viscosity of the second adhesive layer.

[0007] Optionally, the bioadhesive patch includes a main body and a separation layer membrane, the main body is bonded to the separation layer membrane, the bioadhesive patch is bonded to the airbag structure through the separation layer membrane, the surface of the main body facing the lesion of the patient's cavity has the second adhesive layer, and the surface where the separation layer membrane is bonded to the airbag structure is provided with a first adhesive layer.

[0008] Optionally, the digestive tract intraluminal delivery device of the bioadhesive patch further includes: an airbag structure, which is arranged at the working end of the delivery tube and can be expanded by inflation or contracted by vacuum, and the bioadhesive patch is bonded to the surface of the airbag structure through the first adhesive layer.

[0009] Optionally, the airbag structure further includes a first docking portion, the working end of the delivery tube includes a second docking portion, and the airbag structure is connected to the working end via the first docking portion and the second docking portion.

[0010] Optionally, the first docking portion and the second docking portion are both magnetic structures, and the airbag structure and the working end are magnetically linked via the first docking portion and the second docking portion.

[0011] Optionally, one of the first docking portion and the second docking portion is a buckle, and the other of the first docking portion and the second docking portion is a latching protrusion, and the first docking portion and the second docking portion are latched together via the buckle and the latching protrusion.

[0012] Optionally, the first butt joint portion and the second butt joint portion are both adhesive layers, and the first butt joint portion and the second butt joint portion are bonded together via the adhesive layers.

[0013] According to the second aspect of the present application, a method for using a gastrointestinal tract delivery device for a bioadhesive patch is provided, the method comprising: extending one end of an endoscope of a robotic arm into the patient's cavity; connecting the airbag structure of the gastrointestinal tract delivery device for the bioadhesive patch to the working end of the delivery tube, and extending the airbag structure through the delivery channel inside the robotic arm into the patient's cavity; inflating the airbag structure to expand the airbag structure; driving the airbag structure to move by the robotic arm, adhering the bioadhesive patch to the target position in the patient's cavity by the airbag structure, and detaching the airbag structure from the bioadhesive patch; stopping inflating the airbag structure, shrinking the airbag structure, and leaving the patient's cavity together with the robotic arm.

[0014] According to the digestive tract intracavitary delivery device of the bioadhesive patch provided in the embodiment of the present application, the mechanical arm is extended into the patient's cavity, and the airbag structure is inflated to expand the airbag structure, and the mechanical arm is manipulated to drive the airbag structure to move. Thus, the bioadhesive patch can be adhered to the target position in the patient's cavity, that is, the lesion in the patient's cavity, through the airbag structure, so as to achieve the drug supply to the lesion in the patient's cavity, and a variety of drugs can be used, and the drug can also treat the lesion for a long time, reducing the number of times the drug is delivered to the patient's cavity, and alleviating the patient's pain. After the drug supply is completed, the airbag structure is stopped from being inflated, so that the airbag structure is contracted and leaves the patient's cavity together with the mechanical arm. Convenient and fast, easy to operate. The size of the bioadhesive patch is generally 3-4cm, and it is square. It can help repair the fistula in the case of fistula. In addition, the bioadhesive patch can also isolate the wound surface at the wound from the body fluid in the cavity, such as the gastric fluid inside the gastric cavity, to reduce the influence of the digestive fluid of the digestive tract on the recovery of the wound and improve the treatment effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in the embodiments of the present application. For ordinary technicians in this field, other drawings can also be obtained based on these drawings.

[0016] Figure 1 This is a schematic diagram of the structure of the digestive tract intraluminal delivery device of the bioadhesive patch according to an embodiment of the present application delivering medicine into the patient's cavity, and at this time the airbag structure is contracted;

[0017] Figure 2 This is a schematic diagram of the structure of the digestive tract intraluminal delivery device of the bioadhesive patch according to an embodiment of the present application delivering medicine into the patient's cavity, and the airbag structure is expanded at this time;

[0018] Figure 3 It is a schematic diagram of the structure of the digestive tract intraluminal delivery device of the bioadhesive patch according to the embodiment of the present application delivering medicine into the patient's cavity, at which time the bioadhesive patch is adhered to the target position in the patient's cavity;

[0019] Figure 4 A schematic diagram of the three-dimensional structure of an embodiment of a bioadhesive patch of a digestive tract intraluminal delivery device according to an embodiment of the present application;

[0020] Figure 5 It is an enlarged structural diagram of a digestive tract intraluminal delivery device of a bioadhesive patch according to an embodiment of the present application;

[0021] Figure 6 The figure is a flow chart of a method for using the digestive tract intraluminal delivery device of the bioadhesive patch according to an embodiment of the present application.

[0022] Description of reference numerals:

[0023] A bioadhesive patch intraluminal delivery device 100;

[0024] Delivery pipe 10; working end 101;

[0025] Bioadhesive patch 20; main body 201; adhesive area 2011; drug area 2012; separation layer film 202;

[0026] Airbag structure 30;

[0027] Robotic arm 200. DETAILED DESCRIPTION

[0028] In order to enable those skilled in the art to better understand the technical solutions in the embodiments of the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments in the embodiments of the present application should fall within the scope of protection of the embodiments of the present application.

[0029] As mentioned before, in a medical environment, fistulas may occur in the patient's cavity due to various diseases (such as surgery, ulcers, etc.), and suppuration often occurs. There is currently no effective clinical treatment. If a robotic arm (such as a digestive endoscope, etc.) is inserted into the patient's cavity to directly deliver drugs to the lesion, the drug is in a free state and cannot be continuously targeted to the target area. If physical clamping is performed directly with a medical tissue clip, the wound cannot heal normally due to the presence of purulent components and the lack of effective drug treatment components in the tissue clip. In addition, when the diameter of the fistula is large, the tissue tension is large and it may be impossible to clamp it. At the same time, high tension is not conducive to wound healing. Therefore, it is necessary to provide patients with a medical device that can provide continuous drug treatment for a long time and can seal the wound with low tension to help the wound heal.

[0030] Therefore, the present application provides a bioadhesive patch for digestive tract intracavitary delivery and a method of use, which can continuously supply medicine to the patient's intracavitary wound in the form of a bioadhesive patch for a long time, thereby reducing the number of times the medicine is supplied to the patient's cavity.

[0031] The following is attached to the instruction manual Figure 1-Figure 5 The digestive tract intraluminal delivery device 100 of the bioadhesive patch according to the first embodiment of the present application is described in detail.

[0032] like Figure 1-Figure 3 As shown, a digestive tract intracavity delivery device 100 of a bioadhesive patch can be extended into a target position in a patient's cavity through a delivery channel inside a mechanical arm 200. The mechanical arm 200 is a medical mechanical arm 200 with an endoscope commonly used in medical environments. The medical mechanical arm has a delivery pipeline inside, which can deliver drugs or items such as hemostatic clips to the patient's cavity through the delivery pipeline, and the end of the mechanical arm 200 has a nozzle and an air jet hole, which can spray water and air. It also has an endoscope, which can be used to observe the internal situation of the patient's cavity. The endoscope can be connected to the display of an external control system to present the internal picture of the patient's cavity on the display. The digestive tract intracavity delivery device 100 of the bioadhesive patch includes a delivery tube 10 and a bioadhesive patch 20. The delivery tube 10 includes a working end 101, and the working end 101 can be extended into the patient's cavity. One end of the robotic arm 200 with the endoscope can be extended into the patient's cavity, so as to operate on the target area inside the patient's cavity, and the target area is the lesion inside the patient's cavity.

[0033] like Figure 1-Figure 3 As shown, the bioadhesive patch 20 is set to the working end 101 of the delivery tube 10, so that it can be extended into the patient's cavity through the working end 101 of the delivery tube 10, and the bioadhesive patch 20 can be driven to move into the patient's cavity together, and the bioadhesive patch 20 can be adhered to the lesion in the patient's cavity through the operation of the mechanical arm 200. Specifically, the two side surfaces of the bioadhesive patch 20 respectively have a first adhesive layer and a second adhesive layer, the first adhesive layer is adhered to the working end 101, and the second adhesive layer can be adhered to the target position in the patient's cavity. Therefore, the bioadhesive patch 20 can be stably adhered to the delivery tube 10 through the first adhesive layer, and the bioadhesive patch 20 can be adhered to the lesion in the patient's cavity through the second adhesive layer, and the bioadhesive patch 20 can be used to continuously supply medicine to the patient's lesion for a long time, reduce the number of drug delivery times to the patient's cavity, alleviate the patient's pain, and operate conveniently and quickly. For some cavities with large internal tension, or locations with large wound surfaces, or situations where suppuration has occurred at the wound, which is not conducive to treatment, the bioadhesive patch 20 can be stably bonded to the wound, and targeted continuous drug supply is provided to the wound, with good treatment effect. And for tissues with large tension, it can ensure that the tissues in the cavity can be combined together to facilitate healing. For situations where full-thickness injuries occur, the bioadhesive patch 20 can also stably ensure continuous drug supply.

[0034] According to the digestive tract intraluminal delivery device 100 of the bioadhesive patch provided in the embodiment of the present application, the working end 101 of the delivery tube 10 is extended into the patient's cavity, and the airbag structure 30 is inflated to expand the airbag structure 30, and the mechanical arm 200 is manipulated to drive the airbag structure 30 to move. Thus, the bioadhesive patch 20 can be adhered to the target position in the patient's cavity, that is, the lesion in the patient's cavity, through the airbag structure 30, so as to achieve the drug supply to the lesion in the patient's cavity, and a variety of drugs can be used, and the drugs can also treat the lesion for a long time, reducing the number of times the drug is delivered to the patient's cavity, and alleviating the patient's pain. After the drug supply is completed, stop inflating the airbag structure 30, shrink the airbag structure 30, and leave the patient's cavity together with the mechanical arm 10. Convenient and fast, easy to operate. The bioadhesive patch 20 can help repair the fistula in the case of fistula. Furthermore, the bioadhesive patch 20 can also isolate the wound surface at the wound from the body fluid in the cavity, such as the gastric fluid in the stomach cavity, thereby reducing the influence of the digestive fluid in the digestive tract on the wound recovery and improving the treatment effect.

[0035] In some embodiments of the present invention, the bioadhesive patch 20 may be square and may be 3-4 cm in size, so that it can completely cover larger wounds, such as fistulas with a size of more than 1 cm, to ensure the therapeutic effect.

[0036] In some embodiments of the present invention, Figure 4 As shown, the bioadhesive patch 20 includes a main body 201, and one side surface of the main body 201 has an adhesive area 2011 and a drug area 2012. The drug area 2012 can be provided with a variety of medical drugs, and the adhesive area 2011 is an edible dissolving material. The drug area 2012 can be provided with a variety of drugs to correspond to different treatment purposes according to actual use requirements. For example, if a bleeding point appears inside the patient's cavity, a hemostatic agent can be provided in the drug area 2012 to achieve a hemostatic effect on the bleeding point. The adhesive area 2011 uses an edible dissolving material, which can realize the digestion of the bioadhesive patch 20 as a whole, without the patient's excretion, and can be automatically digested in the patient's body, which is simple to operate.

[0037] In some embodiments of the present invention, the viscosity of the first adhesive layer is less than that of the second adhesive layer. Since the bioadhesive patch 20 needs to be adhered to the patient's lesion area in the patient's cavity, in order to achieve quick separation between the medical body and the working end 101, the viscosity of the first adhesive layer can be made less than that of the second adhesive layer, which can ensure that the bioadhesive patch 20 can be smoothly separated from the working end 101, and ensure that the bioadhesive patch 20 can be stably adhered to the patient's lesion to prevent falling off.

[0038] In some embodiments of the present invention, Figure 4As shown, the bioadhesive patch 20 includes a main body 201 and a separation layer film 202. The main body 201 is bonded to the separation layer film 202, and the bioadhesive patch 20 is bonded to the airbag structure 30 through the separation layer film 202. The surface of the main body 201 facing the lesion of the patient's cavity has a second adhesive layer, and the surface of the separation layer film 202 bonded to the airbag structure 30 is provided with a first adhesive layer. Therefore, when the bioadhesive patch 20 needs to be adhered to the patient's lesion, the main body 201 of the bioadhesive patch 20 can be separated from the separation layer film 202, so that it can be stably adhered to the patient's lesion.

[0039] In some embodiments of the present invention, Figure 1-Figure 3 As shown, the digestive tract intracavitary delivery device 100 of the bioadhesive patch also includes an airbag structure 30, which is set to the working end 101 of the delivery tube 10, and the airbag structure 30 can be expanded or shrunk by inflation, and the bioadhesive patch 20 is bonded to the surface of the airbag structure 30 through the first adhesive layer. Therefore, when the airbag structure 30 is inflated, the bioadhesive patch 20 can be adhered to the patient's lesion through the airbag structure 30, and the bioadhesive patch 20 can be stably connected to the patient's lesion by pressing the airbag structure 30. The use of the airbag structure 30 can ensure that the patient's internal cavity structure is protected during pressing, and prevent hard objects from pressing the patient's cavity and causing the patient to feel uncomfortable. And the use of the airbag structure 30 can reduce the volume of the airbag structure 30 when the airbag structure 30 shrinks.

[0040] In some embodiments of the present invention, Figure 5 As shown, the airbag structure 30 further includes a first docking portion 301 , the working end 101 of the delivery tube 10 includes a second docking portion 1011 , and the airbag structure 30 and the working end 101 are connected via the first docking portion 301 and the second docking portion 1011 .

[0041] This enables quick disassembly and assembly between the airbag structure 30 and the delivery tube 10. For some cases where a large-sized airbag structure is required, the delivery tube 10 can be first inserted into the delivery pipe of the robot arm 200, and after the delivery tube 10 passes through the delivery pipe, the airbag structure 30 can be connected to the working end 101 of the delivery tube 10 to achieve quick disassembly and assembly.

[0042] In some embodiments of the present invention, the first docking portion and the second docking portion are both magnetic structures, and the airbag structure and the working end are magnetically connected through the first docking portion and the second docking portion, which is convenient for disassembly and assembly.

[0043] In some embodiments of the present invention, one of the first docking portion and the second docking portion is a buckle, and the other of the first docking portion and the second docking portion is a convex clamp, and the first docking portion and the second docking portion are connected by the buckle and the convex clamp, which is convenient for assembly and disassembly, and the buckle and the convex clamp connection method is stable.

[0044] In some embodiments of the present invention, both the first butt joint part and the second butt joint part are adhesive layers, and the first butt joint part and the second butt joint part are bonded by the adhesive layer, which is convenient for assembly and disassembly, and quick and easy.

[0045] The following is attached to the instruction manual Figure 6 A method for using a bioadhesive patch intraluminal delivery device 100 according to a second aspect of the present application is described in detail, wherein the method comprises:

[0046] Step S1: inserting one end of the endoscope of the robotic arm into the patient's cavity;

[0047] Step S2: connecting the balloon structure of the digestive tract intraluminal delivery device of the bioadhesive patch to the working end of the delivery tube, and extending the balloon structure into the patient's cavity through the delivery channel inside the robotic arm;

[0048] Step S3: Inflate the airbag structure 30 to expand the airbag structure 30;

[0049] Step S4: the airbag structure 30 is driven to move by the robot arm 10, the bioadhesive patch 20 is adhered to the target position in the patient's cavity by the airbag structure 30, and the airbag structure 30 is separated from the bioadhesive patch 20;

[0050] Step S5: Stop inflating the airbag structure 30 , and shrink the airbag structure 30 , and let it leave the patient's cavity together with the robotic arm 10 .

[0051] According to the method of using the digestive tract intraluminal delivery device 100 of the bioadhesive patch provided in the embodiment of the present application, the mechanical arm 200 is extended into the patient's cavity, and the airbag structure 30 is inflated to expand the airbag structure 30, and the mechanical arm 10 is manipulated to drive the airbag structure 30 to move. Thus, the bioadhesive patch 20 can be adhered to the target position in the patient's cavity, that is, the lesion in the patient's cavity, through the airbag structure 30, so as to achieve the drug supply to the lesion in the patient's cavity, and a variety of drugs can be used, and the drug can also treat the lesion for a long time, reducing the number of times the drug is delivered to the patient's cavity, and alleviating the patient's pain. After the drug supply is completed, stop inflating the airbag structure 30, shrink the airbag structure 30, and leave the patient's cavity together with the mechanical arm 10. Convenient and fast, easy to operate. The size of the bioadhesive patch 20 is generally 3-4cm, and is square. It can help repair the fistula in the case of fistula. Furthermore, the bioadhesive patch 20 can also isolate the wound surface at the wound from the body fluid in the cavity, such as the gastric fluid in the stomach cavity, thereby reducing the influence of the digestive fluid in the digestive tract on the wound recovery and improving the treatment effect.

[0052] The above implementation methods are only used to illustrate the embodiments of the present application, and are not limitations on the embodiments of the present application. Ordinary technicians in the relevant technical field can make various changes and modifications without departing from the spirit and scope of the embodiments of the present application. Therefore, all equivalent technical solutions also belong to the scope of the embodiments of the present application. The scope of patent protection of the embodiments of the present application should be limited by the claims.

Claims

1. A bioadhesive patch intraluminal delivery device, characterized in that: The digestive tract intracavitary delivery device of the bioadhesive patch can be extended into a target position in the patient's cavity through a delivery channel inside the mechanical arm, and the digestive tract intracavitary delivery device of the bioadhesive patch includes: a delivery tube, the delivery tube comprising a working end, the working end being capable of extending into the cavity of the patient; A bioadhesive patch, wherein the bioadhesive patch is arranged on the working end of the delivery tube, and the two side surfaces of the bioadhesive patch respectively have a first adhesive layer and a second adhesive layer, wherein the first adhesive layer is adhered to the working end, and the second adhesive layer can be adhered to a target position in the patient's cavity.

2. The digestive tract intraluminal delivery device of the bioadhesive patch according to claim 1, characterized in that: The bioadhesive patch comprises a main body, one side surface of the main body is provided with an adhesive area and a drug area, the drug area can be provided with a variety of medical drugs, and the adhesive area is an edible dissolving material.

3. The digestive tract intraluminal delivery device of the bioadhesive patch according to claim 2, characterized in that: The viscosity of the first adhesive layer is lower than that of the second adhesive layer.

4. The digestive tract intraluminal delivery device of the bioadhesive patch according to claim 2, characterized in that: The bioadhesive patch includes a main body and a separation layer membrane, the main body is bonded to the separation layer membrane, and the bioadhesive patch is bonded to the airbag structure through the separation layer membrane. The surface of the main body facing the lesion of the patient's cavity has the second adhesive layer, and the surface of the separation layer membrane bonded to the airbag structure is provided with a first adhesive layer.

5. The digestive tract intraluminal delivery device of the bioadhesive patch according to claim 1, characterized in that: The bioadhesive patch intraluminal delivery device also includes: The airbag structure is arranged at the working end of the delivery tube, and the airbag structure can be expanded by inflation or contracted by deflating, and the bioadhesive patch is bonded to the surface of the airbag structure through the first adhesive layer.

6. The digestive tract intraluminal delivery device of the bioadhesive patch according to claim 5, characterized in that: The airbag structure also includes a first docking portion, the working end of the delivery tube includes a second docking portion, and the airbag structure is connected to the working end via the first docking portion and the second docking portion.

7. The digestive tract intraluminal delivery device of the bioadhesive patch according to claim 7, characterized in that: The first docking portion and the second docking portion are both magnetic structures, and the airbag structure and the working end are magnetically connected via the first docking portion and the second docking portion.

8. The digestive tract intraluminal delivery device of the bioadhesive patch according to claim 5, characterized in that: One of the first docking portion and the second docking portion is a buckle, and the other of the first docking portion and the second docking portion is a locking protrusion, and the first docking portion and the second docking portion are locked together by the buckle and the locking protrusion.

9. The digestive tract intraluminal delivery device of the bioadhesive patch according to claim 5, characterized in that: The first butt joint portion and the second butt joint portion are both adhesive layers, and the first butt joint portion and the second butt joint portion are bonded together by the adhesive layers.

10. A method for using a bioadhesive patch intraluminal delivery device, characterized in that: The method comprises: Insert one end of the endoscope of the robotic arm into the patient's cavity; Connecting the balloon structure of the digestive tract intraluminal delivery device of the bioadhesive patch to the working end of the delivery tube, and extending the balloon structure into the patient's cavity through the delivery channel inside the mechanical arm; Inflating the airbag structure to expand the airbag structure; The mechanical arm drives the airbag structure to move, adheres the bioadhesive patch to a target position in the patient's cavity through the airbag structure, and separates the airbag structure from the bioadhesive patch; The inflation of the airbag structure is stopped, and the airbag structure is deflated and leaves the patient's cavity together with the robotic arm.

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