A medical sodium hyaluronate gel and preparation method thereof
By adding modified sodium hyaluronate, anti-degradable agent and synergist to prepare medical sodium hyaluronate gel and dialysis treatment, the problem that gels in the prior art cannot have both anti-degradable ability and low toxicity, and achieve stronger anti-degradable ability and lower toxicity.
CN119745729APending Publication Date: 2025-04-04南京竹海生物科技有限公司
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Patent Information
- Application Number
- CN202411910705.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-24
- Publication Date
- 2025-04-04
AI Technical Summary
Technical Problem
The medical sodium hyaluronate gel prepared by the prior art cannot have both anti-degradation ability and low toxicity.
Method used
By adding modified sodium hyaluronate, anti-degradable agent and synergist to deionized water and dialysis treatment, a modified sodium hyaluronate gel with a specific molecular weight is prepared to improve its anti-degradation ability and reduce toxicity.
Benefits of technology
The prepared medical sodium hyaluronate gel has stronger anti-degradation ability and extremely low cytotoxicity, and has a wider application prospect.
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Abstract
The present invention relates to the technical field of biomedical materials, and in particular to a medical sodium hyaluronate gel and a preparation method thereof, wherein the preparation method of the present invention is as follows: modified sodium hyaluronate is added to deionized water, pH is adjusted to 7.3-7.5 with sodium hydroxide solution, and then antidegradants and synergists are added in sequence and mixed uniformly to obtain medical sodium hyaluronate gel; the modified sodium hyaluronate is prepared by sodium hyaluronate powder, N-hydroxysuccinimide, carbodiimide, and cysteamine hydrochloride; the antidegradation is prepared by heat treatment of lithium bromide solution after raw silk degumming; the synergist is prepared by sodium alginate, sodium periodate, and ethylene glycol. The antidegradant and synergist of the specific molecular weight added by the present invention can be cross-linked with the modified sodium hyaluronate gel, so as to improve the anti-degradation ability of the medical sodium hyaluronate gel, so that it has a wider application prospect.
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