Production method of lamiophlomis rotata dripping pill

Abstract

The invention discloses a lamiophlomis rotata dripping pill production method, belongs to the technical field of Chinese patent medicine production, and aims to solve the problem that lamiophlomis rotata extract powder cannot be completely dissolved during large-tank melting. The method comprises the following steps: preparing lamiophlomis rotata extract powder, burdening, premixing, melting materials, dripping for dewaxing, selecting pills, packaging and warehousing. According to the method, the material melting time is greatly shortened, the material melting procedure can be smoothly completed within 1.5 hours when a 700L large material tank is used, the working hours are remarkably shortened, and energy is saved. And after the dripping process is carried out, because the material is uniformly dissolved, the dripper cannot be blocked by the material, so that the manpower and the working time for cleaning a plug are saved, the whole production process becomes smooth, and the product quality is ensured.

Description

Technical Field

[0001] The invention belongs to the technical field of Chinese patent medicine production, and particularly relates to a method for producing a duyiwei dripping pill. Background Art

[0002] Duyiwei dripping pills are dripping pills made by melting and dripping Duyiwei extract powder and polyethylene glycol. Our company's preparation process is to melt polyethylene glycol-4000, add Duyiwei extract powder, stir evenly and then drip. The chemical process of this process has always been to chemically process small materials in the early stage, and the chemical tank uses a 10L small tank. Its uniformity can still meet the process requirements. However, after expanding production, replacing the chemical tank and using a 700L large chemical tank, a batch of materials is chemically processed and stirred at one time, and the previous small tank chemical process has the following problems: 1. A large amount of Radix Angelicae Pubescentis powder was wrapped by the molten auxiliary materials. Even if the material temperature was adjusted to 100℃ and stirred for more than 10 hours, there were still a large number of wrapped powder lumps that could not be dissolved.

[0003] 2. After filtering with a 40-mesh sieve, a large amount of drug powder is filtered out, resulting in drug powder waste, batch reduction, and decreased product content.

[0004] 3. There are still a lot of unmelted powder particles in the filtered slurry, and the dripper will be blocked quickly during dripping, making it impossible to produce smoothly.

[0005] Based on the problems in the above-mentioned background technology, the production personnel proposed a method for producing a unique dripping pill. Summary of the invention

[0006] The object of the present invention is to provide a method for producing a radix serrata dripping pill, so as to solve the problem that the radix serrata extract powder cannot be completely dissolved when it is mixed in a large tank.

[0007] In order to solve the above problems, the technical solution of the present invention is: A method for producing a single-ingredient dripping pill, the method comprising the following steps: S1. Preparation of Lamiophlomis extract powder; The Lamiophlomis herb that has passed the quality inspection is pre-processed, extracted, concentrated, dried, and crushed to prepare the Lamiophlomis herb extract; S2, ingredients; Check the names and quantities of polyethylene glycol 4000 and Lamiophlomis extract powder. After checking, weigh polyethylene glycol-4000 and Lamiophlomis extract powder and mix them in a ratio of 2.43:1. S3, premix; Premix the prepared materials to the extent that the extract powder is completely dispersed in the polyethylene glycol 4000; S4, chemical materials; Add the premixed materials into the steaming tank several times, and turn on the stirring paddle of the steaming tank at the same time. When the materials are completely dissolved, the steaming is completed. S5, dripping dewaxing; Control the combined large-scale industrialized dripping pill machine to keep it in a circulating state, sieve the melted material and add it into the storage tank, and then start dripping; The drug droplets are cooled and formed by liquid paraffin, flow out from the outlet of the organic glass column with the liquid paraffin, and are sent to the pill collecting hopper of the pill collecting centrifuge via a conveyor belt, and dewaxed by a flat centrifuge; S6, pill selection; The dewaxed pills are put into a rotary screening machine to select unqualified large and small pills, and then the pill selection machine is used to select the sticky and tailing pills. The qualified pills are weighed and marked. In this link, the intermediate inspection is carried out; S7, packaging and storage; The selected balls are packed inside and the finished product is inspected simultaneously; After that, it will be outsourced and put into storage.

[0008] Furthermore, in the extraction step of the extract powder of the Radix Angelicae Pubescentis in S1, water was added and decocted three times, each time for 1 hour, and then concentrated after mixing; in the concentration step, vacuum concentration was adopted to concentrate to d=1.30g / ml (80°C); in the drying step, it was dried at 75±5°C; in the crushing step, the dried Radix Angelicae Pubescentis extract was crushed to a fineness of 120 mesh, and intermediate inspection was carried out in this step.

[0009] Furthermore, a 700L steaming tank is used in S4. Before steaming, the steam valve of the steaming tank is opened, the steam passing pressure does not exceed 0.3MPa, the temperature of the temperature controller is set to 90±5℃, and the temperature inside the tank is heated to 90±5℃.

[0010] Furthermore, in S4, the rotation speed is set to 30 r / min, and stirring is performed for 1.5 hours or more.

[0011] Furthermore, the liquid start-up temperature of the pill machine in S5 is set to 70°C, the oil bath temperature is set to 90±5°C, the nozzle temperature is set to 20-30°C; and the cooling temperature is set to 0-10°C.

[0012] Furthermore, in S5, the melted material is passed through a 40-mesh sieve and added into a storage tank.

[0013] Furthermore, during the dripping process of S5, the dripping rate was controlled between 30-50 drops / minute, and the liquid level was controlled between 2-5 cm; during the dripping process, the weight of 10 pills was checked every 30 minutes, and the weight of the pills was controlled between 40.05 and 49.95 mg / pill.

[0014] The beneficial effects of the present invention are as follows: The present invention investigates the root cause of the agglomeration of the extract powder of the herb in the existing process, and finds that the fine powder of the herb, which has been crushed to 120 meshes, is not easy to disperse when added to the melted polyethylene glycol 4000, and is easily wrapped by the melted polyethylene glycol 4000. In addition, at a high temperature of 90±5°C, the extract powder of the herb softens, which is more unfavorable for dispersion, thereby causing agglomeration. Therefore, the present invention introduces a premixing link of ingredients, firstly, polyethylene glycol 4000 and the powder are mixed at a ratio of 2.43:1, and the degree of premixing is preferably such that the extract powder is completely dispersed in the polyethylene glycol 4000, and then the premixed materials are added to the steaming tank for mixing in multiple times, and the premixing eliminates the premise that the powder is not easy to disperse, so the optimized process greatly reduces the risk of agglomeration during mixing.

[0015] The present invention greatly shortens the time of chemical preparation. A 700L chemical preparation tank can successfully complete the chemical preparation process in less than 1.5 hours, significantly shortening the working hours and saving energy. After entering the dripping process, the dripper will no longer be blocked by the material due to the uniform chemical preparation, thus saving the manpower and working hours for cleaning the plug, making the entire production process smooth and ensuring product quality. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a process flow chart of the present invention; DETAILED DESCRIPTION

[0017] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0018] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the invention as claimed but is merely representative of selected embodiments of the present invention.

[0019] Example 1 like Figure 1 As shown, a method for producing a single-ingredient dripping pill is divided into the following steps: S1. Preparation of Lamiophlomis extract powder; The Lamiophlomis herb that has passed the quality inspection is pre-processed, extracted, concentrated, dried, and crushed to prepare Lamiophlomis herb extract powder.

[0020] Specifically: In the extraction stage, water was added and boiled three times, each time for 1 hour, and then concentrated after mixing; In the concentration step, the product was concentrated under reduced pressure to d = 1.30 g / ml (80 °C); In the drying process, drying is carried out at 75±5℃; In the crushing stage, the dried extract of Du Yiwei is crushed to a fineness of 120 mesh, and intermediate inspection is carried out in this stage.

[0021] S2, ingredients; Check the names and quantities of polyethylene glycol 4000 and Lamiophlomis extract powder. After verification, weigh 364.5 kg of polyethylene glycol-4000 and 150 kg of Lamiophlomis extract powder and mix them in the ratio of 2.43:1.

[0022] S3, premix; The prepared materials are premixed to a degree that the extract powder is completely dispersed in the polyethylene glycol 4000.

[0023] S4, chemical materials; Use a 700L steaming tank, open the steam valve of the steaming tank, the steam passing pressure does not exceed 0.3MPa, set the temperature of the temperature controller to 90±5℃, and heat the tank to 90±5℃; Add the premixed materials into the steaming tank several times, turn on the stirring paddle of the steaming tank, set the speed to 30r / min, stir for 1.5 hours, and complete the steaming after it is completely dissolved.

[0024] S5, dripping dewaxing; Control the start-up temperature of the combined large-scale industrialized pill machine to 70℃, the oil bath temperature to 90±5℃, and the nozzle temperature to 20-30℃; the cooling temperature reaches 0-10℃, and it is in a circulating state. Pass the melted material through a 40-mesh sieve and add it into the storage tank. Filter out 1kg of insoluble material, and then start dripping.

[0025] During the dripping process, the dripping speed is adjusted according to actual conditions, the dripping speed is controlled between 30 and 50 drops / minute, and the liquid level is controlled between 2 and 5 cm, so that the pills are round; during the dripping process, the weight of 10 pills is checked every 30 minutes, and the weight of the pills is controlled between 40.05 and 49.95 mg / pill, and the dripper is not blocked. Since the original process takes about 1 hour to clean the dripper once, the present invention can save the working hours of cleaning the dripper by solving the blockage of the dripper from the root, so the dripping process can shorten the cleaning time of the dripper by at least 7 working hours of 2 operators.

[0026] The drug droplets are cooled and formed by liquid paraffin, flow out from the outlet of the plexiglass column with the liquid paraffin, and are sent to the pill collecting hopper of the pill collecting centrifuge via a conveyor belt, and dewaxed by a flat centrifuge.

[0027] S6, pill selection; The dewaxed pills are added to a rotary screening machine to select unqualified large and small pills, and then a pill selecting machine is used to select the sticky and tailing pills. The qualified pills are weighed and marked, and intermediate inspection is carried out in this link.

[0028] The total weight of the meatballs that pass the inspection can reach 510kg.

[0029] S7, packaging and storage; The selected balls are packed inside and the finished product is inspected simultaneously; After that, it will be outsourced and put into storage.

[0030] Comparative Example 1 The difference from Example 1 is that: S4, chemical materials; Use the same 700L steaming tank, open the steam valve of the steaming tank, the steam pressure does not exceed 0.3MPa, set the temperature of the temperature controller to 90±5℃, and heat the tank to 90±5℃; Add the prepared polyethylene glycol 4000 into the steaming tank several times, and at the same time turn on the stirring paddle of the steaming tank and set the speed to 30r / min.

[0031] Keep stirring during the process of mixing, slowly add the Chinese medicine powder to the melted polyethylene glycol 4000, and start mixing. The mixing time is more than 12 hours. Filter with a 40-mesh sieve before dripping, and filter out about 30 kg of insoluble materials.

[0032] Compared with the method of the present invention, the stirring time of the chemical material is significantly longer, and significantly more insoluble materials are filtered out.

[0033] S5, dripping dewaxing; The same large-scale combined industrial dripping pill machine was used, but due to the insufficient degree of chemical material processing, the dripper had to be cleaned once every 2 hours or so. It took 2 operators about 1 hour to clean the dripper. After the dripping of this batch of drugs was completed, the dripper was cleaned about 7 times, which took 14 working hours for 2 operators.

[0034] In Example 1 of the method of the present invention, the time for cleaning the dripper is saved.

[0035] S6, pill selection; This step is consistent with Example 1, and the total weight of the balls that passed the inspection is 480kg.

[0036] Compared with the process optimized by the method of the present invention in Example 1, 510 kg of qualified meatballs were produced, with a difference of 30 kg and a meatball weight of 45 mg, which is equivalent to about 666,667 more meatballs. Each bag contains 42 meatballs, so there are 15,873 more bags. The raw material cost of each bag is calculated at 0.3 yuan, which creates a value of 4,762 yuan.

[0037] These output values ​​are only the cost price of one batch of products. Calculated in the medium and long term of production, the process improvement of the method of the present invention can generate very significant economic value.

Claims

1. A method for producing a single-ingredient dripping pill, characterized in that: The method is as follows: S1. Preparation of Lamiophlomis extract powder; The Lamiophlomis herb that has passed the quality inspection is pre-processed, extracted, concentrated, dried, and crushed to prepare the Lamiophlomis herb extract; S2, ingredients; Check the names and quantities of polyethylene glycol 4000 and Lamiophlomis extract powder. After checking, weigh polyethylene glycol-4000 and Lamiophlomis extract powder and mix them in a ratio of 2.43:

1. S3, premix; Premix the prepared materials to the extent that the extract powder is completely dispersed in the polyethylene glycol 4000; S4, chemical materials; Add the premixed materials into the steaming tank several times, and turn on the stirring paddle of the steaming tank at the same time. When the materials are completely dissolved, the steaming is completed. S5, dripping dewaxing; Control the combined large-scale industrialized dripping pill machine to keep it in a circulating state, sieve the melted material and add it into the storage tank, and then start dripping; The drug droplets are cooled and formed by liquid paraffin, flow out from the outlet of the organic glass column with the liquid paraffin, and are sent to the pill collecting hopper of the pill collecting centrifuge through a conveyor belt, and dewaxed by a flat centrifuge; S6, pill selection; The dewaxed pills are put into a rotary screening machine to select unqualified large and small pills, and then the pill selection machine is used to select the sticky and tailing pills. The qualified pills are weighed and marked. In this link, the intermediate inspection is carried out; S7, packaging and storage; The selected balls are packed inside and the finished product is inspected simultaneously; After that, it will be outsourced and put into storage.

2. The method for producing a Lamiaceae dripping pill according to claim 1, characterized in that: In the extraction process of the extract powder of the Radix Angelicae Pubescentis in S1, water is added and decocted three times, each time for 1 hour, and then concentrated after mixing; in the concentration process, vacuum concentration is adopted to concentrate to d=1.30g / ml (80℃); in the drying process, drying is carried out at 75±5℃; in the crushing process, the dried Radix Angelicae Pubescentis extract is crushed to a fineness of 120 mesh, and intermediate inspection is carried out in this process.

3. The method for producing a Lamiaceae dripping pill according to claim 1, characterized in that: S4 uses a 700L steaming tank. Before steaming, open the steam valve of the tank, the steam passing pressure does not exceed 0.3MPa, set the temperature of the temperature controller to 90±5℃, and heat the tank to 90±5℃.

4. The method for producing a Lamiaceae dripping pill as claimed in claim 3, characterized in that: In S4, the rotation speed is set to 30 r / min and stirring is performed for 1.5 hours or more.

5. The method for producing a Lamiaceae dripping pill as claimed in claim 4, characterized in that: The starting temperature of the liquid in the pill machine in S5 is set at 70°C, the oil bath temperature is set at 90±5°C, the nozzle temperature is set at 20-30°C; and the cooling temperature is set at 0-10°C.

6. The method for producing a Lamiaceae dripping pill according to claim 5, characterized in that: In S5, the melted material is passed through a 40-mesh sieve and added into a storage tank.

7. The method for producing a Lamiaceae dripping pill according to claim 6, characterized in that: During the dripping process of S5, the dripping rate was controlled between 30-50 drops / minute, and the liquid level was controlled between 2-5 cm; during the dripping process, the weight of 10 pills was checked every 30 minutes, and the weight of the pills was controlled between 40.05 and 49.95 mg / pill.

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