Acne-removing Chinese medicinal composition and acne-removing cosmetics

Abstract

The invention belongs to the technical field of traditional Chinese medicine cosmetology, and specifically relates to an anti-acne Chinese medicine composition and an anti-acne cosmetic. The raw materials of the composition include forsythia, phellodendron, honeysuckle, dandelion, gentian, ginseng, centella asiatica, bezoar and borneol. The anti-acne cosmetic contains the anti-acne Chinese medicine composition. The Chinese medicine composition has reasonable compatibility, monarch, minister, assistant and guiding, and synergistic effects, which can effectively remove acne and eliminate redness and swelling, and can also repair skin barrier, so as to treat both the symptoms and the root causes.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine cosmetology, and particularly relates to an anti-acne Chinese medicine composition and an anti-acne cosmetic. Background Art

[0002] Acne on human skin is a non-contagious chronic inflammation of the hair follicles and sebaceous glands, which manifests as small round pustules on a dark red or bright red inflammatory base, commonly known as acne, blackheads, and acne; its occurrence is caused by multiple factors such as excessive secretion of skin sebum, abnormal keratinization of hair follicles, massive reproduction of Propionibacterium acnes, and inflammatory response; it is prone to recurrence, involving the face, chest and back, and may leave scars.

[0003] Common skin acne treatments mainly include the use of salicylic acid, fruit acid, azelaic acid and its derivatives to soften and peel off the stratum corneum to improve the skin's hyperkeratotic environment. Or topical retinoic acid, benzoyl peroxide, and antibiotic preparations. However, the use of organic acid exfoliants can easily cause the skin's stratum corneum to become thinner, the barrier function to be damaged, and the skin is more prone to problems such as redness and stinging. Retinoic acid, benzoyl peroxide and other substances themselves have a strong skin irritation effect, which can easily cause problems such as skin redness and swelling. Topical antibiotics may cause Propionibacterium acnes to develop drug resistance.

[0004] At present, Western medicine mainly uses androgen antagonists, antibiotics, retinoids, etc. to treat this disease. There are certain effects, but there are also obvious side effects, such as liver damage, teratogenicity, slow bone formation, endocrine disorders, and sexual dysfunction.

[0005] The application of TCM beauty prescriptions has a long history and many written records. In modern times, under the guidance of TCM theory, the application of TCM prescriptions has good curative effects on a variety of damaging skin diseases. Doctors believe that acne mainly occurs on the face, mostly due to unclear lung qi, heat in the lung meridian, and exogenous wind, cold, and dampness, which leads to internal depression of lung qi, stagnation of blood heat and condensation on the face. The cause of acne is mainly "heat evil". In modern times, heat-clearing drugs are generally used, which are divided into heat-clearing and detoxification, heat-clearing and fire-purging, heat-clearing and cooling blood, heat-clearing and dampness-drying, heat-clearing and dampness-removing, etc. Heat-clearing and detoxification are mainly rhubarb, honeysuckle, forsythia, chrysanthemum, isatis indigo leaf, dandelion, etc., and heat-clearing and dampness-drying drugs are mainly Phellodendron, Coptis chinensis, Scutellaria baicalensis, etc. Patent CN202111530556.8 discloses cosmetics made from Forsythia suspensa, Phellodendron amurense, Honeysuckle and Taraxacum officinale, which have antibacterial and anti-inflammatory effects. This patent is mainly aimed at infants and young children, and solves the safety issues of infant products and the redness and swelling of infant skin. However, it does not have a good effect on the removal of acne, recovery from redness and swelling, and repair of skin barriers in adults. It can only improve mild redness and swelling, but cannot completely eliminate it. Summary of the invention

[0006] In order to solve the current technical problems, the present invention provides an acne-removing Chinese medicine composition and acne-removing cosmetics. The acne-removing cosmetics containing the Chinese medicine composition can not only effectively remove acne and eliminate redness and swelling, but also repair the skin barrier, treating both the symptoms and the root causes.

[0007] The technical solution of the present invention is as follows:

[0008] The invention discloses an acne-removing Chinese medicinal composition. The raw materials of the composition include forsythia, phellodendron, honeysuckle, dandelion, gentian, ginseng, centella asiatica, bezoar and borneol.

[0009] Preferably, the raw materials of Forsythia suspensa, Phellodendron amurense, Honeysuckle, Taraxacum officinale, Gentiana scabra, Ginseng and Centella asiatica need to be extracted to obtain extracts as components of the composition.

[0010] Preferably, the bezoar in the raw material is crushed before being used as a component of the composition.

[0011] Preferably, the acne-removing Chinese medicine composition includes, by weight, 2-10 parts of Forsythia suspensa extract, 1-5 parts of Phellodendron chinense extract, 1-5 parts of Honeysuckle extract, 1-5 parts of Taraxacum extract, 0.5-2 parts of Gentiana scabra extract, 0.5-2 parts of Ginseng extract, 0.5-2.5 parts of Centella asiatica extract, 0.01-0.08 parts of Bezoar, and 0.1-2 parts of Borneol.

[0012] Preferably, the composition comprises 2-8 parts of Forsythia suspensa extract, 1-4 parts of Phellodendron amurense extract, 1-4 parts of Honeysuckle extract, 1-4 parts of Taraxacum officinale extract, 0.5-1.8 parts of Gentiana scabra extract, 0.5-1.6 parts of Ginseng extract, 0.5-2 parts of Centella asiatica extract, 0.01-0.06 parts of Bezoar, and 0.1-1 parts of Borneol.

[0013] Further preferably, the composition comprises 5.632 parts of Forsythia suspensa extract, 2.816 parts of Phellodendron amurense extract, 2.816 parts of Honeysuckle extract, 2.816 parts of Taraxacum officinale extract, 1.5 parts of Gentiana scabra extract, 1.2 parts of Ginseng extract, 1.8 parts of Centella asiatica extract, 0.04 parts of Bezoar, and 0.5 parts of Borneol.

[0014] Preferably, the method for extracting the extracts of Forsythia suspensa, Phellodendron amurense, Taraxacum officinale and Lonicera japonica is as follows: add Forsythia suspensa, Phellodendron amurense, Taraxacum officinale and Lonicera japonica to water and boil three times, combine the decoctions, filter, and concentrate the filtrate to a clear paste with a relative density of 1.10-1.15 (50°C), add ethanol to make the alcohol content reach more than 70%, let stand, filter, and concentrate the filtrate under reduced pressure until there is no alcohol taste, and continue to concentrate to a relative density of 1.20-1.40 (50°C) to obtain the extract.

[0015] An acne-removing cosmetic contains the above-mentioned acne-removing traditional Chinese medicine composition.

[0016] Preferably, the proportion of the Chinese herbal composition in the anti-acne cosmetic is 1.0-2.5%, that is, the mass of the Chinese herbal composition accounts for 1.0-2.5% of the total mass of the anti-acne cosmetic.

[0017] Preferably, the cosmetics also include additives and auxiliary ingredients used in the preparation of the cosmetics. Further preferably, the additives and auxiliary ingredients include one or more of solvents, moisturizers, thickeners, pH adjusters, emollients, preservatives, fragrances, etc.

[0018] Preferably, the cosmetic is a facial cream, lotion, essence or facial mask.

[0019] The present invention adds the heat-clearing and dampness-drying medicine gentian, the heat-clearing and detoxifying medicine bezoar, the heat-clearing and diuretic and dampness-infiltrating medicine centella, the deficiency-tonifying medicine ginseng, and the heat-clearing and detoxifying and pain-relieving borneol on the basis of forsythia, phellodendron, honeysuckle and dandelion; gentian and phellodendron are heat-clearing and dampness-drying medicines, and the two medicines are used together, and the effect is better, and the anti-inflammatory effect is more obvious; bezoar, as a heat-clearing and detoxifying medicine, can also promote blood circulation and dissipate stagnation, promote blood circulation and glandular secretion; centella clears heat and dampness, and assists in removing dampness while clearing heat; ginseng replenishes deficiency and consolidates the exterior, and is used to remove evil and go out; while borneol clears heat and relieves pain, it can also cool and relieve swelling. The above several medicinal materials, on the basis of clearing heat, detoxify and kill insects, promote diuresis and dampness, promote blood circulation and dissipate stagnation, invigorate qi and invigorate deficiency, cool and relieve swelling and relieve pain, and act synergistically to achieve better effects of soothing, removing acne and repairing.

[0020] Pharmacological effects of each raw material:

[0021] Forsythia suspensa: bitter in taste and cool in nature, it has the functions of clearing away heat and detoxifying, reducing swelling and dispersing nodules, and evacuating wind-heat. It is used for carbuncle, scrofula, mastitis, and erysipelas. It has antibacterial effects and can inhibit Salmonella typhi, Salmonella paratyphi, Escherichia coli, Shigella dysenteriae, Corynebacterium diphtheriae, Vibrio cholerae, Staphylococcus aureus, Streptococcus aureus, etc., and has a great inhibitory effect on the growth of pox.

[0022] Huangbai: It tastes bitter and is cold in nature. It has the functions of clearing away heat and dampness, purging fire and removing steaming, detoxifying and treating sores. It is used for sores, swelling and toxins, eczema and wet sores. It has a strong function of clearing heat and drying dampness, and is good at treating wet sores in the lower abdomen. It has the ability to inhibit the growth of bacteria and fungi, and has a certain effect on the treatment of skin infections, acne, etc. It can promote the regeneration of damaged skin tissue and accelerate wound healing.

[0023] Honeysuckle: sweet in taste and cold in nature, it has the functions of clearing away heat and detoxifying, dispersing wind-heat, and is used for carbuncles, furuncles, throat paralysis, and erysipelas; it has antiviral, antibacterial, and anti-inflammatory effects, and is effective in improving the treatment of acne.

[0024] Dandelion: It tastes bitter and sweet, and is cold in nature. It has the functions of clearing away heat and detoxifying, reducing swelling and dispersing nodules, and promoting diuresis and relieving stranguria. It is used for carbuncle, mastitis, and scrofula. Dandelion is antibacterial and anti-inflammatory, and is rich in carotene, vitamin C and minerals, which can improve dermatitis or acne on the skin.

[0025] Bezoar: sweet in taste and cool in nature, it has the functions of clearing the heart, resolving phlegm, opening the orifices, cooling the liver and calming wind, and detoxifying. It is used for sore throat, mouth ulcers, carbuncles and furuncles.

[0026] Gentian: It tastes bitter and is cold in nature. It can clear away heat and dampness, and relieve liver and gallbladder fire. It is good at treating damp-heat in the liver meridian. Many doctors now use Longdan Xiegan Decoction to treat dermatitis and eczema and have achieved good results. It has anti-inflammatory effects and can also improve oily and rough skin conditions.

[0027] Ginseng: sweet, slightly bitter in taste, slightly warm in nature, can replenish vital energy, restore pulse, strengthen the spleen and lungs, promote the production of body fluids and nourish blood, and calm the mind and improve intelligence.

[0028] Centella asiatica: It tastes bitter and spicy, is cold in nature, and has the functions of clearing away heat and dampness, detoxifying and reducing swelling. It is used for carbuncles, sores, and injuries from falls. It has the effects of reducing inflammation and swelling, can block the expansion of acne area, and has a lightening effect. In addition, it can also promote collagen formation, help damaged tissues heal, and has a good repair function.

[0029] Borneol: It tastes spicy and bitter, is cool in nature, and has the functions of invigorating the mind, clearing away heat and relieving pain; it has the effects of relieving pain and swelling, and can assist in removing acne.

[0030] The forsythia suspensa in the prescription of the present invention is bitter in taste and cool in nature, and has the functions of clearing away heat and detoxifying, reducing swelling and dispersing nodules, and is a holy medicine for sores. It is combined with the phellodendron chinense, which can clear away heat and dampness, purge fire and detoxify, and treat sores, as the main medicine; honeysuckle clears heat and detoxifies, evacuates wind-heat, reduces swelling and dissipates toxins, and is an important medicine for treating sores; bezoar clears the heart and detoxifies, and relieves fever, and is an important medicine for clearing heat and detoxifying, which assists the forsythia suspensa in the functions of clearing heat and detoxifying, reducing swelling and detoxifying, and gentian clears heat and dries dampness, purges liver and gallbladder fire, and helps Huangbai has the functions of clearing away heat and dampness, detoxifying and killing insects. The three medicines are used together as ministerial medicine; Taraxacum officinale has the functions of reducing swelling and dispersing nodules, clearing away heat and toxins; Centella asiatica has the functions of clearing away heat and promoting dampness, detoxifying and reducing swelling, and is used to enhance the functions of detoxifying and reducing swelling, dispersing blood stasis and discharging pus; Ginseng has the functions of replenishing qi and blood, tonifying deficiency and strengthening the body, and has helped to expel pathogens; Borneol has the functions of clearing away heat and relieving pain, and reducing swelling, and is used together as adjuvant medicine; all the medicines are used together to achieve the functions of clearing away heat and detoxifying, reducing swelling and curing sores, and dispersing pathogens and dispersing blood stasis.

[0031] The invention provides an acne-removing Chinese medicine composition and acne-removing cosmetics. The Chinese medicine composition has a reasonable compatibility, a main ingredient, a secondary ingredient, an adjuvant ingredient and an guiding ingredient, and a synergistic effect. It can effectively remove acne and eliminate redness and swelling, and can also repair the skin barrier, treating both the symptoms and the root cause, and has the effect of preventing recurrence. The product quality stability is good. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 This is the comparison chart before and after treatment of treatment case 1;

[0033] Figure 2 This is a comparison chart before and after treatment of treatment case 2. DETAILED DESCRIPTION

[0034] The technical solutions in the present invention will be described clearly and completely below in conjunction with the specific implementation of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0035] The extraction methods or acquisition methods of the drugs used in the following examples and comparative examples are as follows:

[0036] The method for extracting the extracts of forsythia, phellodendron, dandelion and honeysuckle is as follows: forsythia, phellodendron, dandelion and honeysuckle are placed together, decocted three times with water, the first time for 1 hour, the second time for 45 minutes, and the third time for 30 minutes, the decoction is combined, filtered, and the filtrate is concentrated to a clear paste with a relative density of 1.10-1.15 (50° C.), ethanol is added to make the alcohol content reach 70%, and the mixture is allowed to stand for 24 hours, filtered, and the filtrate is concentrated under reduced pressure until there is no alcohol taste, and further concentrated to a relative density of 1.20-1.40 (50° C.), and the extract is obtained, which includes forsythia extract, phellodendron extract, dandelion extract and honeysuckle extract. It is also possible to select the extraction method in the prior art to extract separately, or select the products available on the market.

[0037] Gentiana extract, Centella asiatica extract and ginseng extract can be purchased from the market or extracted using extraction methods disclosed in the prior art. Gentiana extract contains gentiopicroside content ≥1200 μg / ml, Centella asiatica extract contains total glycoside content ≥80%, and ginseng extract is an extract of ginseng root, wherein the content of ginsenosides is ≥20%.

[0038] The bezoar is crushed to a fineness of less than 80 mesh.

[0039] Example 1

[0040] An acne-removing Chinese medicinal composition comprises, by weight, 2 parts of Forsythia suspensa extract, 1 part of Phellodendron amurense extract, 1 part of Honeysuckle extract, 1 part of Taraxacum officinale extract, 0.5 parts of Gentiana scabra extract, 0.5 parts of Ginseng extract, 0.5 parts of Centella asiatica extract, 0.01 parts of Bezoar and 0.1 parts of Borneol.

[0041] Example 2

[0042] An acne-removing Chinese medicinal composition comprises, by weight, 10 parts of Forsythia suspensa extract, 5 parts of Phellodendron amurense extract, 5 parts of Honeysuckle extract, 5 parts of Taraxacum officinale extract, 2 parts of Gentiana scabra extract, 2 parts of Ginseng extract, 2.5 parts of Centella asiatica extract, 0.08 parts of Bezoar and 2 parts of Borneol.

[0043] Example 3

[0044] An acne-removing Chinese medicinal composition comprises, by weight, 8 parts of Forsythia suspensa extract, 4 parts of Phellodendron amurense extract, 4 parts of Honeysuckle extract, 4 parts of Taraxacum officinale extract, 1.8 parts of Gentiana scabra extract, 1.6 parts of Ginseng extract, 2 parts of Centella asiatica extract, 0.06 parts of Bezoar and 1 part of Borneol.

[0045] Example 4

[0046] An acne-removing Chinese medicinal composition comprises, by weight, 6 parts of Forsythia suspensa extract, 3 parts of Phellodendron amurense extract, 3 parts of Honeysuckle extract, 3 parts of Taraxacum officinale extract, 1.5 parts of Gentiana scabra extract, 1.2 parts of Ginseng extract, 1.8 parts of Centella asiatica extract, 0.04 parts of Bezoar and 0.5 parts of Borneol.

[0047] Example 5

[0048] An acne-removing Chinese medicine composition, calculated by mass, comprises 5.632 parts of Forsythia suspensa extract, 2.816 parts of Phellodendron chinense extract, 2.816 parts of Honeysuckle extract, 2.816 parts of Taraxacum officinale extract, 1.5 parts of Gentiana scabra extract, 1.2 parts of Ginseng extract, 1.8 parts of Centella asiatica extract, 0.04 parts of Bezoar, and 0.5 parts of Borneol.

[0049] A Chinese medicinal composition for removing acne, comprising, by weight, 5.632 parts of Forsythia suspensa extract, 2.816 parts of Phellodendron chinense extract, 2.816 parts of Honeysuckle extract, 2.816 parts of Taraxacum officinale extract, and 1.5 parts of Gentiana scabra extract.

[0050] Test example

[0051] According to the existing process, 1000g of each of the essence products containing the composition of Example 5 and Comparative Example 1 were prepared, referred to as the essence of Example 5 and the essence of Comparative Example 1, and then the test was carried out. In addition to the Chinese medicine composition containing Example 5 and Comparative Example 1, the other additives and auxiliary materials were the essence ingredients. The process can refer to the following steps, and other existing processes can also be used to prepare the essence product. Compared with Example 5, the substances that are not in Comparative Example 1 can be supplemented with water or other auxiliary materials.

[0052] The essence preparation process includes the following steps:

[0053] S1: Weigh 80g of Forsythia suspensa, 40g of Phellodendron chinense, 40g of Honeysuckle and 40g of Taraxacum officinale, put the above four ingredients together, add water and boil for three times, the first time for 1 hour, the second time for 45 minutes, and the third time for 30 minutes, combine the decoctions, filter, and concentrate the filtrate to a clear paste with a relative density of 1.10-1.15 (50°C), add ethanol to make the alcohol content reach 70%, let it stand for 24 hours, filter, and decompress the filtrate to remove alcohol taste, and continue to concentrate to a relative density of 1.20-1.40 (50°C) to obtain an extract, which is set aside; crush the bezoar to a fineness of less than 80 mesh;

[0054] S2: Weigh 0.04g of bezoar, add 5g of butylene glycol, grind until fine and uniform, transfer to a suitable container, add 0.5g of PEG-40 hydrogenated castor oil, heat to 70-75°C, keep warm for 8 minutes, then add water, let stand and filter for later use;

[0055] S3: Weigh 0.5 g of borneol, add appropriate amount of butylene glycol and PEG-40 hydrogenated castor oil into a suitable container, add water, place in a 60°C water bath to dissolve completely, and set aside;

[0056] S4: Weigh 1.8 g of Centella asiatica extract into a suitable container, add water, and dissolve completely for later use;

[0057] S5: Weigh 40-60 g of glycerol, 2-8 g of 1,2-hexanediol, and 2-8 g of p-hydroxyacetophenone into a container, place it in a 60°C water bath and dissolve it completely for later use;

[0058] S6: Add disodium EDTA to the main pot, add 250g water, stir and heat until dissolved, heat to 80℃, and homogenize for 3min; maintain the temperature at 80℃, add the mixture in S1, stir and keep warm for 25min to sterilize; when the temperature drops to 55℃, add the mixture in S5 to the main pot and stir evenly; when the temperature drops to 47-52℃, add the mixtures in S2 and S3 in turn and stir evenly; when the temperature drops to below 45℃, add the mixture in S4 and 1.5g gentian extract and 1.2g ginseng extract in turn, then add butylene glycol, glycerin, and p-hydroxyacetophenone, add water, stir evenly, and you will get 1000g of the essence product.

[0059] test

[0060] 1. Cosmetic safety assessment

[0061] According to the relevant provisions of the "Technical Guidelines for Safety Assessment of Cosmetics", the microorganisms, harmful substances and risk substances of the products were tested, and the ingredients in the formula, including the possible presence of diethylene glycol, dioxane, and pesticide residues, were safety assessed. The results showed that the essence of Example 5 and the essence of Comparative Example 1 would not cause harm to human health under normal, reasonable and foreseeable use.

[0062] The safety assessment concluded as follows:

[0063] The essence of Example 5 and the essence of Comparative Example 1 are leave-on cosmetics, suitable for the face, and can be used daily. The main exposure route is percutaneous absorption. According to the characteristics of the product, the exposure assessment of this product only considers the percutaneous route.

[0064] Through comprehensive evaluation of the following aspects of the product:

[0065] (1) The safety assessment results of each ingredient show that all ingredients will not cause harm to human health at the concentrations in this product;

[0066] (2) The testing and evaluation results of possible safety risk substances show that they will not cause harm to human health;

[0067] (3) The microbiological test results show that the microorganisms of the product meet the relevant requirements of the "Technical Specifications for Safety of Cosmetics";

[0068] (4) The harmful substance test results show that the harmful substance content of the product complies with the relevant requirements of the "Technical Specifications for Safety of Cosmetics";

[0069] (5) No harmful interactions are foreseen between the ingredients in the formulation.

[0070] In summary, it is believed that this product will not cause harm to human health under normal, reasonable and foreseeable conditions of use.

[0071] 2. Toxicological tests related to bezoar

[0072] According to the "Technical Specifications for Safety of Cosmetics", relevant toxicology tests were conducted on bezoar, and the results showed that:

[0073] (1) Acute eye irritation test: non-irritating under (no rinsing) conditions;

[0074] (2) Skin phototoxicity test: No skin phototoxicity was observed;

[0075] (3) Multiple skin irritation tests: non-irritating;

[0076] (4) In vitro mammalian cell chromosome aberration test: negative;

[0077] (5) Skin allergy test: No skin allergy was observed;

[0078] (6) Skin photoallergy test: sensitization rate is 0%, sensitization grade is I, and sensitization intensity is weak;

[0079] (7) Bacterial reverse mutation test: negative;

[0080] (8) Subacute oral toxicity test: Bezoar was exposed to SD rats by oral gavage. After 28 consecutive days of exposure and 14 days of follow-up observation, no abnormal conditions or animal deaths were observed in any dose group during the exposure period, and no delayed toxic reactions were observed in the follow-up observation group. During the entire test period, no toxicological changes were found in any index detection in any dose group. Therefore, it is believed that under the experimental conditions, the dose level at which no adverse effects were observed in the subacute oral toxicity test of the test substance bezoar on rats is 200 mg / kg·bw.

[0081] 3. Human skin patch test

[0082] The test products are the essence of Example 5 and the essence of Comparative Example 1. Based on the "Technical Specification for Safety of Cosmetics" (2015 edition), a human skin patch test was conducted on this product. In one group, there were 30 subjects, aged 20-60 years old, with an average age of 38.8±13.3 years old, and the test product was the essence of Example 5; in another group, there were 30 subjects, aged 22-42 years old, with an average age of 29.1±5.5 years old, and the test product was the essence of Comparative Example 1.

[0083] Patch test method: Select qualified patch test equipment and use the closed patch test method. Place 0.022 ml of the test substance in the patch tester and apply it to the back of the subject with a low-allergenic tape. Remove the test substance after 24 hours and observe the skin reaction at 0.5, 24, and 48 hours after removal. Record the results according to the skin reaction grading standards for closed patch tests in Table 1 in Chapter 7 of the "Technical Specifications for Safety of Cosmetics" (2015 edition).

[0084] Test results: The results of the human skin patch test are shown in Tables 1 and 2 below.

[0085] Table 1 is a summary of the results of the human skin patch test of the essence of Example 5

[0086]

[0087] The results of the human skin patch test in Table 1 show that no adverse skin reactions occurred in any of the 30 subjects.

[0088] Table 2 is a summary of the results of the human skin patch test of the essence of Comparative Example 1

[0089]

[0090] Table 2 shows that the results of the human skin patch test showed that no adverse skin reactions occurred in 30 subjects.

[0091] 4. Efficacy experiment

[0092] Experimental group: 34 valid test persons, aged 18-43 years old, 25 females and 9 males, and the inclusion criteria for the test subjects were: 1) aged between 18 and 45 years old, healthy women or men; 2) there were at least 2 acne on the facial skin, but no nodules or cysts that were difficult to improve with clinical preparations, and the test product was the essence of Example 5; Control group: 35 valid test persons, aged 18-38 years old, 19 females and 16 males, and the inclusion criteria for the test subjects were: 1) aged between 18 and 45 years old, healthy women or men; 2) there were at least 2 acne on the facial skin, but no nodules or cysts that were difficult to improve with clinical preparations, and the test product was the essence of Comparative Example 1.

[0093] Product usage steps: After cleansing every morning and evening, apply the essence evenly on the face and gently massage until absorbed. Use continuously for 7 days.

[0094] Test time points: before product use (T0), 3 days after product use (T1), and 7 days after product use (T2).

[0095] Test environment: temperature range of 20-22°C and relative humidity range of 40-60%.

[0096] Test method: Use instruments to objectively detect skin hemoglobin, skin a* value (probe test, select skin color test probe), manual acne counting, skin a* value (image analysis, first take the image with a facial image analyzer, then analyze it with ImagePro-Plus software), and transepidermal water loss (probe test, select skin water loss test probe Tewameter TM Hex), and conduct a comprehensive evaluation of the safety, soothing, acne-removing and repairing effects of the test product.

[0097] Judgment basis: Compared with before use of the product, at least one major indicator (skin hemoglobin, skin a* value (probe test)) is significantly improved at any time point after use of the product, which can be judged as having a soothing effect; compared with before use of the product, at least one major indicator (artificial count of comedones, skin a* value (image analysis)) is significantly improved at any time point after use of the product, which can be judged as having an anti-acne effect; after use of the product, the amount of water loss through the epidermis is significantly reduced, which can be judged as having a skin barrier repair effect.

[0098] Table 3 shows the test results of the experimental group:

[0099]

[0100]

[0101] Table 4 shows the test results of the control group:

[0102]

[0103]

[0104] During the entire test, no subject experienced adverse skin reactions.

[0105] According to the data in Tables 3 and 4, after applying the essences of Example 5 and Comparative Example 1 for 7 days, the skin hemoglobin, skin a* value (probe test), acne manual count, skin a* value (image analysis) and transepidermal water loss obtained by the experimental group test all showed significant differences on the 3rd and 7th days of the test; while the skin hemoglobin and transepidermal water loss of the control group did not show significant differences when used for 3 days, and only showed significant differences when used for 7 days. It is not difficult to find that the change rate of the experimental group after use is greater than that of the control group before use, and significant progress has been achieved. The test results of Tables 3 and 4 effectively prove that applying the essence of Example 5 has a better effect than applying the essence of Comparative Example 1. Whether it is in soothing, removing acne, or in the effect of barrier repair, the essence of Example 5 has a better effect than the essence of Comparative Example 1, especially in the effect of barrier repair, the essence of Example 5 has a very prominent advantage, and the essence of Example 5 takes effect faster than the essence of Comparative Example 1.

[0106] 5. Specific treatment cases:

[0107] Treatment case 1: Liu, female, 34 years old, had large areas of acne on her face. She used the essence product prepared in Example 5, applied it evenly to her face after cleansing every day, once in the morning and once in the evening, for 28 consecutive days. From the third day, the redness of her face decreased. After 28 days of use, 93% of the acne on her face disappeared, which was basically cured. Some pigmentation was temporarily left locally, and no new acne appeared around the original acne. For details, see Figure 1 Continue using until all blackheads disappear and temporary local pigmentation gradually fades, restoring normal skin color.

[0108] Treatment case 2: Zhang, male, 21 years old, had obvious acne on his face, especially on his forehead, and some of them were severely red and swollen. The essence product prepared in Example 5 was applied evenly to the face after cleansing every day, once in the morning and once in the evening, for 28 consecutive days. From the third day, the redness of the face decreased. After 28 days of use, 90% of the acne on the face disappeared, which was basically cured. Pigmentation was temporarily left locally, and no new acne appeared around the original acne. For details, see Figure 2 Continue using until all blackheads disappear and temporary local pigmentation gradually fades, restoring normal skin color.

[0109] In this field, even very well-known manufacturers often receive complaints because the effects of the same product purchased by consumers at different times are quite different, but the manufacturer clearly uses the same formula and the same process during production. This instability of product quality is also an important obstacle that plagues the development of this field. When studying the formula of the present invention, the inventor found that when the mass ratio of Forsythia suspensa extract: Phellodendron chinense extract: Honeysuckle extract: Taraxacum officinale extract in the formula of the present invention is 2:1:1:1, the product quality is very stable, and the product effect is also better. Under this special ratio, the same formula is used to adapt to the same process, and no problem of unstable product quality is found through multiple batches of production; in the formula of the present invention, the cosmetics prepared without using this specific ratio of several medicines also have good efficacy, but there will be a certain degree of quality instability, and its efficacy is not as good as the formula with a specific ratio. The invention provides a traditional Chinese medicine composition, wherein the mass ratio of the forsythia extract: the phellodendron chinense extract: the honeysuckle extract: the dandelion extract is limited to 2:1:1:1, so that a product with stable quality and the best efficacy can be obtained; the traditional Chinese medicine components in a specific ratio can stabilize their own properties and cooperate with other components to play a stable role, effectively avoiding the problem of unstable quality of products produced by the same formula and the same process in different batches, improving the use experience of consumers, increasing consumers' trust in manufacturers, and providing a new idea for solving the problem of product quality stability in the field of cosmetics.

[0110] The present invention provides a Chinese medicine composition, which is used to prepare anti-acne cosmetics. Compared with the anti-acne cosmetics prepared in Comparative Example 1, the anti-acne cosmetics have outstanding advantages in soothing, removing acne and repairing. Compared with Comparative Example 1, the present invention only adds ginseng, Centella asiatica, bezoar, and borneol, and the added amount is also significantly less than that of Forsythia suspensa, Phellodendron chinense, etc., but in terms of efficacy, the anti-acne cosmetics of the present invention are significantly better than the anti-acne cosmetics of Comparative Example 1, which further proves the synergistic effect between the formulas of the Chinese medicine composition of the present invention. The lack of any one or several medicines (even if the lack of one or several medicines accounts for a small proportion) cannot achieve the best efficacy. The anti-acne cosmetics of the present invention have better effects and better quality stability, and have made significant progress.

[0111] In summary, the Chinese medicine composition of the present invention produces a very excellent synergistic effect, accelerates the speed of effectiveness of cosmetics, can better and faster reduce the area of ​​skin redness, reduce the number of acne, speed up the repair of damaged skin barrier, and has the effect of preventing recurrence. The product of the present invention can be used in the short term to solve the problems of acne, redness, and damaged skin barrier in time, and can also be used for a long time. After solving the above problems, continued use can make the skin smooth and delicate, and the skin sensitivity is reduced. The quality stability of the anti-acne cosmetics provided by the present invention is better, which improves the consumer's experience, and also provides a new direction for solving the problem of product quality stability in the cosmetics field.

Claims

1. An acne-removing Chinese medicine composition, characterized in that: The raw materials of the composition include forsythia, phellodendron, honeysuckle, dandelion, gentian, ginseng, centella asiatica, bezoar and borneol.

2. The acne-removing Chinese medicine composition according to claim 1, characterized in that: The forsythia, phellodendron, honeysuckle, dandelion, gentian, ginseng and centella asiatica in the raw materials all need to be extracted to obtain extracts as components of the composition.

3. The acne-removing Chinese medicine composition according to claim 1, characterized in that: The bezoar in the raw material is crushed and then used as a component of the composition.

4. An anti-acne Chinese medicine composition according to claim 2 or 3, characterized in that: By weight, the composition includes 2-10 parts of Forsythia suspensa extract, 1-5 parts of Phellodendron amurense extract, 1-5 parts of Honeysuckle extract, 1-5 parts of Taraxacum officinale extract, 0.5-2 parts of Gentiana scabra extract, 0.5-2 parts of Ginseng extract, 0.5-2.5 parts of Centella asiatica extract, 0.01-0.08 parts of Bezoar and 0.1-2 parts of Borneol.

5. The acne-removing Chinese medicinal composition according to claim 4, characterized in that: By weight, the composition includes 2-8 parts of Forsythia suspensa extract, 1-4 parts of Phellodendron amurense extract, 1-4 parts of Honeysuckle extract, 1-4 parts of Taraxacum extract, 0.5-1.8 parts of Gentiana scabra extract, 0.5-1.6 parts of Ginseng extract, 0.5-2 parts of Centella asiatica extract, 0.01-0.06 parts of Bezoar and 0.1-1 parts of Borneol.

6. The acne-removing Chinese medicinal composition according to claim 5, characterized in that: By mass, the composition includes 5.632 parts of Forsythia suspensa extract, 2.816 parts of Phellodendron chinense extract, 2.816 parts of Honeysuckle extract, 2.816 parts of Taraxacum officinale extract, 1.5 parts of Gentiana scabra extract, 1.2 parts of Ginseng extract, 1.8 parts of Centella asiatica extract, 0.04 parts of Bezoar and 0.5 parts of Borneol.

7. An anti-acne cosmetic, characterized in that: A Chinese medicinal composition for removing acne comprising any one of claims 1 to 6.

8. The anti-acne cosmetic according to claim 7, characterized in that: The proportion of the acne-removing Chinese medicinal composition is 1.0-2.5%.

9. The anti-acne cosmetic according to claim 7, characterized in that: The cosmetics also include additives and auxiliary ingredients used in the preparation of the cosmetics.

10. The anti-acne cosmetic according to claim 7, characterized in that: The cosmetics are face cream, lotion, essence or face mask.

Images