A Chinese medicine composition with kidney-tonifying and bone-strengthening and tendon-relaxing effects, and its preparation method and application

Abstract

The present application relates to the technical field of traditional Chinese medicine, and more particularly to a Chinese medicine composition having the effects of tonifying the kidney and strengthening bones and relaxing tendons and activating collaterals, and a preparation method and application thereof; the raw materials of the Chinese medicine composition include: roasted epimedium, prepared rehmannia root, eucommia bark, processed polygonum multiflorum, cynomorium songaricum, scalded bone drynaria and angelica sinensis, and the mass ratio of the seven Chinese medicines is (265-405):(335-505):(265-405):(335-505):(335-505):(265-405):(265-405). The Chinese medicine composition only uses the seven Chinese medicines for compatibility, thereby ultimately improving the kidney-tonifying and bone-strengthening effect of the Chinese medicine composition with fewer Chinese medicine components.

Description

Technical Field

[0001] The present application relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition having the effects of tonifying the kidney and strengthening bones and relaxing tendons and activating collaterals, and a preparation method and application thereof. Background Art

[0002] In the treatment of bone development and fracture healing diseases, in order to avoid damage to the body, the use of Chinese medicine that is less harmful to the body can reduce the toxic effects of Western medicine. In addition, the current theory of traditional Chinese medicine shows that "the kidneys store essence and bones", "remove stasis, regenerate, and heal bones", and "the treatment of diseases must be based on the root cause". Therefore, using Chinese medicine to achieve the effects of nourishing the kidneys and bones, strengthening the spleen and replenishing qi, promoting blood circulation and removing stasis, repairing tendons and bones, and removing cold and dampness is an effective way to promote bone growth and development and treat bone diseases such as fracture healing.

[0003] Although these Chinese medicines have many formulas and cover most of the kidney-tonifying and bone-strengthening drugs, due to the toxic effects of Chinese medicine on the kidneys themselves, too many Chinese medicine ingredients will affect the efficacy of the kidney-tonifying and bone-strengthening drugs. Summary of the invention

[0004] The present application provides a Chinese medicine composition having the effects of tonifying the kidney and strengthening the bones and relaxing the tendons and activating the collaterals, as well as a preparation method and application thereof, in order to solve the following technical problem: how to improve the kidney-tonifying and bone-strengthening effect of Chinese medicine.

[0005] In the first aspect, the present application provides a traditional Chinese medicine composition with the effects of tonifying the kidney and strengthening the bones and relaxing the muscles and activating the collaterals. The raw materials of the traditional Chinese medicine composition include: roasted epimedium, prepared rehmannia, eucommia, processed polygonum multiflorum, cynomorium songaricum, scalded drynaria and angelica sinensis. The weight m1 of the roasted epimedium, the weight m2 of the prepared rehmannia, the weight m3 of the eucommia, the weight m4 of the processed polygonum multiflorum, the weight m5 of the cynomorium songaricum, the weight m6 of the scalded drynaria and the weight m7 of the angelica sinensis satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=(265~405):(335~505):(265~405):(335~505):(335~505):(265~405):(265~405).

[0006] Optionally, the weight m1 of the roasted Epimedium, the weight m2 of the Rehmannia glutinosa, the weight m3 of the Eucommia ulmoides, the weight m4 of the processed Polygonum multiflorum, the weight m5 of the Cynomorium songaricum, the weight m6 of the scalded Drynaria fortunei and the weight m7 of the Angelica sinensis satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=(265~405):(335~505):(265~405):(335~505):(375~465):(265~405):(265~405).

[0007] Optionally, the weight m1 of the roasted Epimedium, the weight m2 of the Rehmannia glutinosa, the weight m3 of the Eucommia ulmoides, the weight m4 of the processed Polygonum multiflorum, the weight m5 of the Cynomorium songaricum, the weight m6 of the scalded Drynaria fortunei and the weight m7 of the Angelica sinensis satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=(300~365):(375~465):(300~365):(375~465):(375~465):(300~365):(300~365).

[0008] Optionally, the weight m1 of the roasted Epimedium, the weight m2 of the Rehmannia glutinosa, the weight m3 of the Eucommia ulmoides, the weight m4 of the processed Polygonum multiflorum, the weight m5 of the Cynomorium songaricum, the weight m6 of the scalded Drynaria fortunei and the weight m7 of the Angelica sinensis satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=335:420:335:420:420:335:335.

[0009] In a second aspect, the present application provides a method for preparing the Chinese medicine composition according to the first aspect, the method comprising:

[0010] Mixing roasted epimedium, prepared rehmannia root, eucommia bark, processed polygonum multiflorum, cynomorium songaricum, scalded drynaria and angelica sinensis to obtain a mixed Chinese medicine raw material;

[0011] Using water to decoct the mixed Chinese medicinal raw materials at least twice, and then combining and filtering the Chinese medicinal decoctions obtained by decocting to obtain a Chinese medicinal filtrate;

[0012] The traditional Chinese medicine filtrate is concentrated under reduced pressure to obtain a traditional Chinese medicine composition paste.

[0013] Optionally, the mixed Chinese medicinal raw materials are decocted at least twice with water, and then the Chinese medicinal decoctions obtained by decocting are combined and filtered to obtain a Chinese medicinal filtrate, comprising the steps of:

[0014] Using water to perform a first round of decoction on the mixed Chinese medicinal raw materials to obtain a first Chinese medicinal decoction liquid and a decoction residue respectively;

[0015] Using the water to perform a second round of decoction on the decoction residue to obtain a second Chinese medicine decoction;

[0016] The first Chinese medicine decoction and the second Chinese medicine decoction are combined, and then the combined mixed decoction is filtered to obtain a Chinese medicine filtrate.

[0017] Optionally, the decoction time of the first round of decoction is ≥ 1h, and the weight m8 of the water used in the first round of decoction and the weight m9 of the mixed Chinese medicinal raw materials satisfy the relationship: m8:m9=(10-11):1; and / or

[0018] The decoction time of the second round of decoction is ≥1h, and the weight m10 of the water used in the second round of decoction and the weight m9 of the mixed Chinese medicinal raw materials satisfy the relationship: m10:m9=(9-10):1.

[0019] Optionally, the endpoint relative density of the reduced pressure concentration is 1.05 to 1.10.

[0020] In a third aspect, the present application provides a traditional Chinese medicine preparation having the effects of nourishing the kidneys and bones and relaxing muscles and activating collaterals, wherein the traditional Chinese medicine preparation comprises the traditional Chinese medicine composition described in the first aspect.

[0021] In a fourth aspect, the present application provides a method for preparing the traditional Chinese medicine preparation according to the third aspect, the method comprising:

[0022] Mixing and drying dextrin and the traditional Chinese medicine composition for multiple times to obtain traditional Chinese medicine preparation particles;

[0023] Among them, the weight m11 of the dextrin and the weight m12 of the traditional Chinese medicine composition satisfy the relationship: m11:m12=(6.5-13.5):100.

[0024] The above technical solution provided by the embodiment of the present application has the following advantages compared with the prior art:

[0025] The embodiment of the present application provides a Chinese medicine composition with kidney-tonifying and bone-strengthening and tendon-relaxing effects. The Chinese medicine composition uses roasted epimedium, prepared rehmannia root, eucommia bark, processed polygonum multiflorum, cynomorium songaricum, scalded bone drynaria and angelica as a formula, and the weight m1 of the roasted epimedium, the weight m2 of the prepared rehmannia root, the weight m3 of the eucommia bark, the weight m4 of the processed polygonum multiflorum, the weight m5 of the cynomorium songaricum, the weight m6 of the scalded bone drynaria and the weight m7 of the angelica satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=(265-405):(335-505):(265-405):(335-505):(335-505):(265-405):(265-405) , indicating that the Chinese medicine composition uses roasted epimedium as the main medicine, cooked rehmannia and eucommia as the ministerial medicines, processed polygonum multiflorum, cynomorium songaricum and scalded bone drynbu as the adjuvant medicines, and angelica as the assistant. The effects of roasted epimedium on tonifying the kidney and strengthening yang and strengthening tendons and bones are utilized, combined with the effects of cooked rehmannia and eucommia on nourishing blood and nourishing yin, replenishing essence and filling marrow and strengthening tendons and bones, as well as the effects of processed polygonum multiflorum and cynomorium songaricum on warming the kidney and assisting yang and nourishing essence and blood, as well as the effects of scalded bone drynbu on promoting blood circulation and tendon repair and tonifying the kidney and strengthening bones, and the effect of angelica on nourishing blood and activating blood circulation, so that the Chinese medicine composition can have good effects of tonifying the kidney and strengthening bones and relaxing tendons and unblocking meridians; the Chinese medicine composition only uses seven Chinese medicines for compatibility, and can improve the kidney-tonifying and bone-strengthening effect of the Chinese medicine composition with fewer Chinese medicine components. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the present application and, together with the description, serve to explain the principles of the present application.

[0027] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, for ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0028] Figure 1 A schematic flow chart of a method for preparing a Chinese medicine composition having the effects of tonifying the kidney and strengthening bones and relaxing muscles and activating collaterals provided in an embodiment of the present application;

[0029] Figure 2 A detailed schematic diagram of a method for preparing a Chinese medicine composition having the effects of tonifying the kidney and strengthening bones and relaxing muscles and activating collaterals provided in an embodiment of the present application;

[0030] Figure 3 A schematic flow chart of a method for preparing a traditional Chinese medicine preparation having the effects of tonifying the kidney and strengthening bones and relaxing muscles and activating collaterals provided in an embodiment of the present application. DETAILED DESCRIPTION

[0031] In order to make the purpose, technical solution and advantages of the embodiments of the present application clearer, the technical solution in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of this application.

[0032] Various embodiments of the present application may be presented in the form of a range; it should be understood that the description in the form of a range is only for convenience and brevity and should not be understood as a rigid limitation on the scope of the present application; therefore, it should be considered that the range description has specifically disclosed all possible sub-ranges and single numerical values ​​within the range; for example, it should be considered that the range description from 1 to 6 has specifically disclosed sub-ranges, such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., as well as single numbers within the range, such as 1, 2, 3, 4, 5 and 6, which applies regardless of the range; in addition, whenever a numerical range is indicated in this document, it is meant to include any cited numbers (fractions or integers) within the indicated range.

[0033] In this document, the terms including "including" and "including" mean "including but not limited to". Relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. "And / or" describes the association relationship of associated objects, indicating that there can be three relationships. For example, A and / or B can mean: A exists alone, A and B exist at the same time, and B exists alone; where A and B can be singular or plural. "At least one" means one or more, and "plurality" means two or more; "at least one", "at least one of the following" or similar expressions refer to any combination of these items, including any combination of single or plural items; for example, "at least one of a, b, or c", or "at least one of a, b, and c" can all mean: a, b, c, ab (i.e., a and b), ac, bc, or abc, where a, b, and c can be single or multiple. Unless otherwise specified, various raw materials, reagents, instruments and equipment used in this application can be purchased from the market or prepared by existing methods.

[0034] The embodiment of the present application provides a traditional Chinese medicine composition with the effects of tonifying the kidney and strengthening the bones and relaxing the tendons and activating the collaterals. The raw materials of the traditional Chinese medicine composition include: roasted epimedium, prepared rehmannia root, eucommia bark, processed polygonum multiflorum, cynomorium songaricum, scalded drynaria root and angelica sinensis. The weight m1 of the roasted epimedium, the weight m2 of the prepared rehmannia root, the weight m3 of the eucommia bark, the weight m4 of the processed polygonum multiflorum, the weight m5 of the cynomorium songaricum, the weight m6 of the scalded drynaria root and the weight m7 of the angelica sinensis satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=(265~405):(335~505):(265~405):(335~505):(335~505):(265~405):(265~405).

[0035] The weight m1 of the roasted epimedium, the weight m2 of the prepared rehmannia, the weight m3 of the eucommia, the weight m4 of the processed polygonum multiflorum, the weight m5 of the cynomorium songaricum, the weight m6 of the scalded drynaria and the weight m7 of the angelica sinensis satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=265:335:265:335:335:265:265, 265:335:265:335:335:265:405, 265:335:265:335:335:405:265, 265:335:265:335:335:405:265, 265:335:265:335:335:405:405, 265:335:265:335:335:405:405, 265:335:265:335:505:265:265, 265:335:265:335 :505:265:405、265:335:265:335:505:405:265、265:335:265:335:505:405:405、265:335:265:505:335:265:265、265:335:265:505:335:265:40 5. 265:335:265:505:335:405:265, 265:335:265:505:335:405:405, 265:335:265:505:505:265:265, 265:335:265:505:505:265:405, 265:335:265:505:505:265:405. 5:505:505:405:265、265:335:265:505:505:405:405、265:335:405:335:335:265:265、265:335:405:335:335:265:405、265:335:405:335:335:4 05:265, 265:335:405:335:335:405:405, 265:335:405:335:505:265:265, 265:335:405:335:505:265:405, 265:335:405:335:505:405:265, 265:335:405:335:505:405:265 35:405:335:505:405:405, 265:335:405:505:335:265:265, 265:335:405:505:335:265:405, 265:335:405:505:335:405:265, 265:335:405:505: 335:405:405、265:335:405:505:505:265:265、265:335:405:505:505:265:405、265:335:405:505:505:405:265、265:335:405:505:505:405:405、265:505:265:335:335:265:265、265:505:265:335:335:265:405、265:505:265:335:335:405:265、265:505:265:335:335:405:405、265:505:265:335:505:265:265、265:505:265:335:505:265:405、265:505:265:335:505:405:265、265:505:265:335:505:405:405、265:505:265:505:335:265:265、265:505:265:505:335:265:405、265:505:265:505:335:405:265、265:505:265:505:335:405:405、265:505:265:505:505:265:265、265:505:265:505:505:265:405、265:505:265:505:505:405:265、265:505:265:505:505:405:405、265:505:405:335:335:265:265、265:505:405:335:335:265:405、265:505:405:335:335:405:265、265:505:405:335:335:405:405、265:505:405:335:505:265:265、265:505:405:335:505:265:405、265:505:405:335:505:405:265、265:505:405:335:505:405:405、265:505:405:505:335:265:265、265:505:405:505:335:265:405、265:505:405:505:335:405:265、265:505:405:505:335:405:405、265:505:405:505:505:265:265、265:505:405:505:505:265:405、265:505:405:505:505:405:265、265:505:405:505:505:405:405、405:335:265:335:335:265:265、405:335:265:335:335:265:405、405:335:265:335:335:405:265、405:335:265:335:335:405:405、405:335:265:335:505:265:265、405:335:265:335:505:265:405、405:335:265:335:505:405:265、405:335:265:335:505:405:405、405:335:265:505:335:265:265、405:335:265:505:335:265:405、405:335:265:505:335:405:265、405:335:265:505:335:405:405、405:335:265:505:505:265:265、405:335:265:505:505:265:405、405:335:265:505:505:405:265、405:335:265:505:505:405:405、405:335:405:335:335:265:265、405:335:405:335:335:265:405、405:335:405:335:335:405:265、405:335:405:335:335:405:405、405:335:405:335:505:265:265、405:335:405:335:505:265:405、405:335:405:335:505:405:265、405:335:405:335:505:405:405、405:335:405:505:335:265:265、405:335:405:505:335:265:405、405:335:405:505:335:405:265、405:335:405:505:335:405:405、405:335:405:505:505:265:265、405:335:405:505:505:265:405、405:335:405:505:505:405:265、405:335:405:505:505:405:405、405:505:265:335:335:265:265、405:505:265:335:335:265:405、405:505:265:335:335:405:265、405:505:265:335:335:405:405、405:505:265:335:505:265:265、405:505:265:335:505:265:405、405:505:265:335:505:405:265, 405:505:265:335:505:405:405, 405:505:265:505:335:265:265, 405:505:265:505:335:265:405, 405:505:265:505:335:405:265, 405:505:265:505:335:405:405, 405:505:265:505:335:405:405, 405:505:265:505:335:405:405 5:505:265:265、405:505:265:505:505:265:405、405:505:265:505:505:405:265、405:505:265:505:505:405:405、405:505:405:335:335:265:265、405:505:405:335:335:265:405、405:505:405:335:335:405:265、 405:505:405:335:335:405:405, 405:505:405:335:505:265:265, 405:505:405:335:505:265:405, 405:505:405:335:505:405:265, 405:505:405:335:505:405:265, 405:505:405:335:505:405:405, 405:505:405:505:335:265:265, 405:505:405:505:405:50 5:335:265:405, 405:505:405:505:335:405:265, 405:505:405:505:335:405:405, 405:505:405:505:505:265:265, 405:505:405:505:505:265:405, 405:505:405:505:505:405:265 or 405:505:405:505:505:405:405.

[0036] It should be noted that the roasted epimedium, rehmannia root, eucommia bark, processed Polygonum multiflorum, Cynomorium songaricum, scalded Drynaria fortunei and Angelica sinensis all meet the requirements of the "Chinese Pharmacopoeia 2020 Edition".

[0037] It should be noted that the preparation method of the roasted epimedium comprises the steps of: heating and melting suet oil, then adding epimedium shreds, frying with a slow fire until the surface of the epimedium shreds is uniform and glossy, then taking out and cooling to room temperature. In this process, 20 kg of suet oil (oil refining) is required for every 100 kg of epimedium. The roasted epimedium has the effects of tonifying kidney yang, strengthening tendons and bones, and removing rheumatism, and can be used for the treatment of symptoms such as kidney yang deficiency, impotence and spermatorrhea, tendon and bone weakness, rheumatic pain, and numbness and cramps.

[0038] It should be noted that the prepared Rehmannia root is a processed product of raw Rehmannia root. The prepared Rehmannia root has the advantages of nourishing blood and yin and replenishing essence and marrow, and can be used to treat symptoms such as blood deficiency and sallow complexion, palpitations, irregular menstruation, metrorrhagia, liver and kidney yin deficiency, soreness of waist and knees, bone steaming and hot flashes, night sweats and spermatorrhea, internal heat and thirst, dizziness, tinnitus and premature graying of hair.

[0039] It should be noted that the eucommia is the dried bark of Eucommia ulmoides Oliv., a plant of the Eucommia family. The specific preparation method includes: peeling the bark of the Eucommia family plant from April to June when the Eucommia family plant grows, scraping off the rough bark of the Eucommia family plant, then stacking to "sweat" until the inner bark of the Eucommia family plant turns purple-brown, and finally drying it in the sun. The eucommia has the effects of nourishing the liver and kidney, strengthening the tendons and bones, and calming the fetus. It can be used to treat symptoms such as liver and kidney deficiency, sore waist and knees, weak tendons and bones, dizziness, pregnancy bleeding, and fetal movement disorder.

[0040] It should be noted that processed Polygonum multiflorum is a processed product of Polygonum multiflorum. The specific steps are as follows: take the slices or blocks of Polygonum multiflorum, and then mix them with black bean juice according to the stewing method of "General Rules of the Four Parts of the 2020 Edition of the Chinese Pharmacopoeia 0213" to obtain a mixed medicine, place the mixed medicine in a suitable non-iron container, and cook until the black bean juice is absorbed by the tuber; or according to the steaming method of "General Rules of the Four Parts of the 2020 Edition of the Chinese Pharmacopoeia 0213", steam or mix them with black bean juice first and then start steaming until the inside and outside of the tuber are brown, or dry the tuber in the sun until it is half dry, then slice and dry. In the above process, 10kg of black bean juice is needed for every 100kg of Polygonum multiflorum slices (blocks). The processed Polygonum multiflorum has the effects of nourishing the liver and kidney, replenishing the essence and blood, blackening the hair, strengthening the tendons and bones, and resolving turbidity and lowering fat. It can be used to treat symptoms such as blood deficiency and chlorosis, dizziness and tinnitus, premature graying of hair, soreness of the waist and knees, numbness of limbs, metrorrhagia, leukorrhea and hyperlipidemia.

[0041] It should be noted that the Cynomorium songaricum is the dried fleshy stem of the Cynomorium songaricum Rupr. of the Cynomorium family. The general production process is: the complete plant of the Cynomorium family is dug in spring, the top inflorescence is removed, and the remaining stem pieces are cut into sections and dried in the sun. The Cynomorium songaricum has the effects of tonifying kidney yang, benefiting essence and blood, and moistening the intestines and relieving constipation. Therefore, the Cynomorium songaricum can be used to treat symptoms such as kidney yang deficiency, essence and blood deficiency, waist and knee weakness, impotence and spermatorrhea, and dry intestines and constipation.

[0042] It should be noted that the main process of the preparation method of the scalded bone drynour is: weigh the clean bone drynour or clean bone fragments, scald the clean bone drynour or clean bone fragments with hot sand until they swell according to the frying method of "Chinese Pharmacopoeia 2020 Edition Four General Rules 0213" and knock off the hair. The scalded bone drynour has the effects of healing wounds and relieving pain and strengthening the kidney and bones when used internally, and has the effects of eliminating wind and removing spots when used externally. It can be used internally to treat symptoms such as falls, sprains, fractures, kidney deficiency and low back pain, weakness of tendons and bones, tinnitus, deafness and loose teeth; and it can be used externally to treat symptoms such as alopecia areata and vitiligo.

[0043] It should be noted that the angelica is the dried root of Angelica sinensis (Oliv.) Diels, an umbelliferae plant. Generally, the production process is: dig the umbelliferae plants in late autumn, remove the fibrous roots and mud of the umbelliferae plants at the same time, wait for the water of the umbelliferae plants to evaporate slightly, bundle the umbelliferae plants into small bundles, then put them on the shed, and then use fireworks to slowly smoke dry. The angelica has the effects of nourishing blood and activating blood circulation, regulating menstruation and relieving pain, and moistening the intestines and relieving constipation. It can be used for the treatment of symptoms such as blood deficiency and chlorosis, dizziness and palpitations, irregular menstruation, amenorrhea and dysmenorrhea, asthenia and cold abdominal pain, rheumatic arthralgia, falls and injuries, carbuncle ulcers and dry intestines and constipation. In addition, the wine angelica formed by the combination of angelica and wine has the effect of activating blood circulation and relieving menstruation, and can be used for the treatment of symptoms such as amenorrhea and dysmenorrhea, rheumatic arthralgia and falls and injuries.

[0044] In some optional embodiments, the weight m1 of the roasted epimedium, the weight m2 of the prepared rehmannia, the weight m3 of the eucommia, the weight m4 of the processed polygonum multiflorum, the weight m5 of the cynomorium songaricum, the weight m6 of the scalded drynaria and the weight m7 of the angelica satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=(265-405):(335-505):(265-405):(335-505):(375-465):(265-405):(265-405);

[0045] In these embodiments, the weight m1 of roasted epimedium, the weight m2 of prepared rehmannia, the weight m3 of eucommia, the weight m4 of processed polygonum multiflorum, the weight m5 of cynomorium songaricum, the weight m6 of scalded drynaria and the weight m7 of angelica sinensis satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=(265-405):(335-505):(265-405):(335-505):(375-465):(265- 405):(265~405), the Chinese medicine composition further utilizes the kidney-tonifying and yang-strengthening and tendon-strengthening effects of roasted epimedium, cooperates with the blood-tonifying and yin-nourishing, essence-replenishing and marrow-strengthening and tendon-strengthening effects of prepared rehmannia and eucommia, as well as the kidney-warming and yang-boosting and essence-replenishing effects of processed Polygonum multiflorum and Cynomorium songaricum, as well as the blood-tonifying and tendon-strengthening effects of scalded drynaproot on promoting blood circulation and tendon repair and kidney-tonifying and bone-tonifying effects of angelica, so that the Chinese medicine composition can have good kidney-tonifying and bone-tonifying and tendon-relaxing and collateral-dredging effects.

[0046] The weight m1 of the roasted epimedium, the weight m2 of the prepared rehmannia, the weight m3 of the eucommia, the weight m4 of the processed polygonum multiflorum, the weight m5 of the cynomorium songaricum, the weight m6 of the scalded drynaria and the weight m7 of the angelica sinensis satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=265:335:265:335:375:265:265, 265:335:265:335:375:265:405, 265:335:265:335:375:405:265, 265:335:265:335:375:405:265, 265:335:265:335:375:405:405, 265:335:265:335:375:405:405, 265:335:265:335:420:265:265, 265:335:265:335 :420:265:405、265:335:265:335:420:405:265、265:335:265:335:420:405:405、265:335:265:335:465:265:265、265:335:265:335:465:265:40 5. 265:335:265:335:465:405:265, 265:335:265:335:465:405:405, 265:335:265:505:375:265:265, 265:335:265:505:375:265:405, 265:335:265:505:375:265:405 5:505:375:405:265、265:335:265:505:375:405:405、265:335:265:505:465:265:265、265:335:265:505:465:265:405、265:335:265:505:465:4 05:265、265:335:265:505:465:405:405、265:335:405:335:375:265:265、265:335:405:335:375:265:405、265:335:405:335:375:405:265、265:3 35:405:335:375:405:405, 265:335:405:335:465:265:265, 265:335:405:335:465:265:405, 265:335:405:335:465:405:265, 265:335:405:335: 465:405:405、265:335:405:505:375:265:265、265:335:405:505:375:265:405、265:335:405:505:375:405:265、265:335:405:505:375:405:405、265:335:405:505:465:265:265、265:335:405:505:465:265:405、265:335:405:505:465:405:265、265:335:405:505:465:405:405、265:505:265:335:375:265:265、265:505:265:335:375:265:405、265:505:265:335:375:405:265、265:505:265:335:375:405:405、265:505:265:335:465:265:265、265:505:265:335:465:265:405、265:505:265:335:465:405:265、265:505:265:335:465:405:405、265:505:265:505:375:265:265、265:505:265:505:375:265:405、265:505:265:505:375:405:265、265:505:265:505:375:405:405、265:505:265:505:465:265:265、265:505:265:505:465:265:405、265:505:265:505:465:405:265、265:505:265:505:465:405:405、265:505:405:335:375:265:265、265:505:405:335:375:265:405、265:505:405:335:375:405:265、265:505:405:335:375:405:405、265:505:405:335:465:265:265、265:505:405:335:465:265:405、265:505:405:335:465:405:265、265:505:405:335:465:405:405、265:505:405:505:375:265:265、265:505:405:505:375:265:405、265:505:405:505:375:405:265、265:505:405:505:375:405:405、265:505:405:505:465:265:265、265:505:405:505:465:265:405、265:505:405:505:465:405:265、265:505:405:505:465:405:405、405:335:265:335:375:265:265、405:335:265:335:375:265:405、405:335:265:335:375:405:265、405:335:265:335:375:405:405、405:335:265:335:465:265:265、405:335:265:335:465:265:405、405:335:265:335:465:405:265、405:335:265:335:465:405:405、405:335:265:505:375:265:265、405:335:265:505:375:265:405、405:335:265:505:375:405:265、405:335:265:505:375:405:405、405:335:265:505:465:265:265、405:335:265:505:465:265:405、405:335:265:505:465:405:265、405:335:265:505:465:405:405、405:335:405:335:375:265:265、405:335:405:335:375:265:405、405:335:405:335:375:405:265、405:335:405:335:375:405:405、405:335:405:335:465:265:265、405:335:405:335:465:265:405、405:335:405:335:465:405:265、405:335:405:335:465:405:405、405:335:405:505:375:265:265、405:335:405:505:375:265:405、405:335:405:505:375:405:265、405:335:405:505:375:405:405、405:335:405:505:465:265:265、405:335:405:505:465:265:405、405:335:405:505:465:405:265、405:335:405:505:465:405:405、405:505:265:335:375:265:265、405:505:265:335:375:265:405、405:505:265:335:375:405:265, 405:505:265:335:375:405:405, 405:505:265:335:465:265:265, 405:505:265:335:465:265:405, 405:505:265:335:465:405:265, 405:505:265:335:465:405:265, 405:505:265:335:465:405:405, 405:505:265:505:375:265:265, 405:505:265:50 5:375:265:405、405:505:265:505:375:405:265、405:505:265:505:375:405:405、405:505:265:505:465:265:265、405:505:265:505:465:265:405、405:505:265:505:465:265:405、405:505:265:505:465:405:265、405:505:265:505:465:405:405、405:505:405:335:375:265:265、 405:505:405:335:375:265:405, 405:505:405:335:375:405:265, 405:505:405:335:375:405:405, 405:505:405:335:465:265:265, 405:505:405:335:465:265:405, 405:505:405:335:465:405:265, 405:505:405:335:465:405:265, 405:505:405:335:465:405:405, 405:505:405:50 5:375:265:265, 405:505:405:505:375:265:405, 405:505:405:505:375:405:265, 405:505:405:505:375:405:405, 405:505:405:505:465:265:265, 405:505:405:505:465:265:405, 405:505:405:505:465:405:265 or 405:505:405:505:465:405:405.

[0047] In some optional embodiments, the weight m1 of the roasted epimedium, the weight m2 of the prepared rehmannia, the weight m3 of the eucommia, the weight m4 of the processed polygonum multiflorum, the weight m5 of the cynomorium songaricum, the weight m6 of the scalded drynaria and the weight m7 of the angelica satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=(300-365):(375-465):(300-365):(375-465):(375-465):(300-365):(300-365);

[0048] In these embodiments, the weight m1 of roasted epimedium, the weight m2 of prepared rehmannia, the weight m3 of eucommia, the weight m4 of processed polygonum multiflorum, the weight m5 of cynomorium songaricum, the weight m6 of scalded drynaria and the weight m7 of angelica sinensis can satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=(300-365):(375-465):(300-365):(375-465):(375-465):( 300~365):(300~365), further utilizing the kidney-tonifying and yang-strengthening and tendon-strengthening effects of roasted epimedium, combined with the blood-tonifying and yin-nourishing, essence-replenishing and marrow-strengthening and tendon-strengthening effects of prepared rehmannia and eucommia, as well as the kidney-warming and yang-boosting and essence-blood-nourishing effects of processed Polygonum multiflorum and Cynomorium songaricum, as well as the blood-tonifying and tendon-strengthening effects of scalded drynapbud, as well as the blood-tonifying and blood-activating effects of angelica, the Chinese medicine composition can have good kidney-tonifying and bone-strengthening and tendon-relaxing effects.

[0049] The weight m1 of the roasted epimedium, the weight m2 of the prepared rehmannia, the weight m3 of the eucommia, the weight m4 of the processed polygonum multiflorum, the weight m5 of the cynomorium songaricum, the weight m6 of the scalded drynaria and the weight m7 of the angelica sinensis can satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=300:375:300:375:375:300:300, 300:375:300:375:375:300:365, 300:375:300:375:375:365:300, 300:375:300:375:375:365:300, 300:375:300:375:375:365:365, 300:375:300:375:375:365:365, 300:375:300:375:375:365:365, 300:375:300:375:300:375:365:365, 300:375:300:375:300:375:365:365, 300:375:300:375:300:375:365:365 5:465:300:365, 300:375:300:375:465:365:300, 300:375:300:375:465:365:365, 300:375:300:465:375:300:300, 300:375:300:465:375:300:3 65, 300:375:300:465:375:365:300, 300:375:300:465:375:365:365, 300:375:300:465:465:300:300, 300:375:300:465:465:300:365, 300:375:300:465:465:300:365. 00:465:465:365:300、300:375:300:465:465:365:365、300:375:365:375:375:300:300、300:375:365:375:375:300:365、300:375:365:375:375: 365:300、300:375:365:375:375:365:365、300:375:365:375:465:300:300、300:375:365:375:465:300:365、300:375:365:375:465:365:300、300: 375:365:375:465:365:365, 300:375:365:465:375:300:300, 300:375:365:465:375:300:365, 300:375:365:465:375:365:300, 300:375:365:465:375:365:300, 300:375:365:465: 375:365:365、300:375:365:465:465:300:300、300:375:365:465:465:300:365、300:375:365:465:465:365:300、300:375:365:465:465:365:365、300:375:300:375:375:300:300、300:465:300:375:375:300:365、300:465:300:375:375:365:300、300:465:300:375:375:365:365、300:465:300:375:465:300:300、300:465:300:375:465:300:365、300:465:300:375:465:365:300、300:465:300:375:465:365:365、300:465:300:465:375:300:300、300:465:300:465:375:300:365、300:465:300:465:375:365:300、300:465:300:465:375:365:365、300:465:300:465:465:300:300、300:465:300:465:465:300:365、300:465:300:465:465:365:300、300:465:300:465:465:365:365、300:465:365:375:375:300:300、300:465:365:375:375:300:365、300:465:365:375:375:365:300、300:465:365:375:375:365:365、300:465:365:375:465:300:300、300:465:365:375:465:300:365、300:465:365:375:465:365:300、300:465:365:375:465:365:365、300:465:365:465:375:300:300、300:465:365:465:375:300:365、300:465:365:465:375:365:300、300:465:365:465:375:365:365、300:465:365:465:465:300:300、300:465:365:465:465:300:365、300:465:365:465:465:365:300、300:465:365:465:465:365:365、300:375:300:375:375:300:300、365:375:300:375:375:300:365、365:375:300:375:375:365:300、365:375:300:375:375:365:365、365:375:300:375:465:300:300、365:375:300:375:465:300:365、365:375:300:375:465:365:300、365:375:300:375:465:365:365、365:375:300:465:375:300:300、365:375:300:465:375:300:365、365:375:300:465:375:365:300、365:375:300:465:375:365:365、365:375:300:465:465:300:300、365:375:300:465:465:300:365、365:375:300:465:465:365:300、365:375:300:465:465:365:365、365:375:365:375:375:300:300、365:375:365:375:375:300:365、365:375:365:375:375:365:300、365:375:365:375:375:365:365、365:375:365:375:465:300:300、365:375:365:375:465:300:365、365:375:365:375:465:365:300、365:375:365:375:465:365:365、365:375:365:465:375:300:300、365:375:365:465:375:300:365、365:375:365:465:375:365:300、365:375:365:465:375:365:365、365:375:365:465:465:300:300、365:375:365:465:465:300:365、365:375:365:465:465:365:300、365:375:365:465:465:365:365、365:375:300:375:375:300:300、365:465:300:375:375:300:365、365:465:300:375:375:365:300、365:465:300:375:375:365:365、365:465:300:375:465:300:300、365:465:300:375:465:300:365、365:465:300:375:465:365:300, 365:465:300:375:465:365:365, 365:465:300:465:375:300:300, 365:465:300:465:375:300:365, 365:465:300:465:375:300:365, 365:465:300:465:375:365:300, 365:465:300:465:375:365:365, 365:465:300:465:375:365:365 5:465:300:300、365:465:300:465:465:300:365、365:465:300:465:465:365:300、365:465:300:465:465:365:365、365:465:365:375:375:300:300、365:465:365:375:375:300:365、365:465:365:375:375:300:365、 365:465:365:375:375:365:365, 365:465:365:375:465:300:300, 365:465:365:375:465:300:365, 365:465:365:375:465:300:365, 365:465:365:375:465:365:300, 365:465:365:375:465:365:365, 365:465:365:465:375:300:300, 365:465:365:465:365:465:365 5:375:300:365、365:465:365:465:375:365:300、365:465:365:465:375:365:365、365:465:365:465:465:465:300:300、365:465:365:465:465:465:300:365、365:465:365:465:465:465:365:300、365:465:365:465:465:465:365:365.、

[0050] In some optional embodiments, the weight m1 of the roasted epimedium, the weight m2 of the prepared rehmannia, the weight m3 of the eucommia, the weight m4 of the processed polygonum multiflorum, the weight m5 of the cynomorium songaricum, the weight m6 of the scalded drynaria and the weight m7 of the angelica satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=335:420:335:420:420:335:335;

[0051] In these embodiments, the weight m1 of roasted epimedium, the weight m2 of prepared rehmannia, the weight m3 of eucommia, the weight m4 of processed polygonum multiflorum, the weight m5 of cynomorium songaricum, the weight m6 of scalded drynariae and the weight m7 of angelica sinensis can satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=335:420:335:420:420:335:335, which can further clarify the specific composition of the Chinese medicine composition, so as to further utilize the kidney-tonifying and yang-strengthening and tendon-strengthening effects of roasted epimedium, and the effects of prepared rehmannia and eucommia on nourishing blood and nourishing yin, replenishing essence and filling marrow, and strengthening tendons and bones, as well as the effects of processed polygonum multiflorum and cynomorium songaricum on warming the kidney and assisting yang and nourishing essence and blood, as well as the effects of scalded drynariae on promoting blood circulation, repairing tendons, and nourishing the kidney and strengthening bones, and the effect of angelica sinensis on nourishing blood and promoting blood circulation, so as to enable the Chinese medicine composition to have good kidney-tonifying and bone-strengthening and tendon-relaxing and collateral-draining effects.

[0052] Figure 1 A schematic flow chart of a method for preparing a Chinese medicine composition having the effects of tonifying the kidney and strengthening bones and relaxing muscles and activating collaterals provided in an embodiment of the present application is exemplarily shown;

[0053] Based on a general inventive concept, such as Figure 1 As shown, the present application embodiment provides a method for preparing the Chinese medicine composition, the method comprising:

[0054] S1. Mix roasted epimedium, Rehmannia root, Eucommia ulmoides, processed Polygonum multiflorum, Cynomorium songaricum, scalded Drynaria and Angelica sinensis to obtain a mixed Chinese medicine raw material;

[0055] S2. The mixed Chinese medicinal raw materials were decocted at least twice using water, and the decoctions of the Chinese medicinal materials obtained by decocting were combined and filtered to obtain a Chinese medicinal filtrate;

[0056] S3. Concentrate the traditional Chinese medicine filtrate under reduced pressure to obtain a clear paste of the traditional Chinese medicine composition.

[0057] This method is a method for preparing the above-mentioned Chinese medicine composition. The specific composition of the Chinese medicine composition can refer to the above-mentioned embodiment. Since this method adopts part or all of the technical solutions of the above-mentioned embodiment, it at least has all the beneficial effects brought by the technical solutions of the above-mentioned embodiment, which will not be repeated here one by one.

[0058] Figure 2 A detailed schematic diagram of a method for preparing a Chinese medicine composition having the effects of tonifying the kidney and strengthening the bones and relaxing the tendons and activating the collaterals provided in an embodiment of the present application is exemplarily shown;

[0059] In some optional embodiments, such as Figure 2 As shown, the mixed Chinese medicine raw materials are decocted at least twice with water, and then the Chinese medicine decoctions obtained by decocting are combined and filtered to obtain the Chinese medicine filtrate, including the steps of:

[0060] S201. The mixed Chinese medicinal raw materials are subjected to a first round of decoction using water to obtain a first Chinese medicinal decoction and a decoction residue;

[0061] S202. Using the water to perform a second round of decoction on the decoction residue to obtain a second Chinese medicine decoction;

[0062] S203. The first Chinese medicine decoction and the second Chinese medicine decoction are combined, and then the combined mixed decoction is filtered to obtain a Chinese medicine filtrate;

[0063] In these embodiments, the mixed Chinese medicinal materials are subjected to the first round of decoction and the second round of decoction, which can promote the sufficient precipitation of each effective ingredient in the mixed Chinese medicinal materials to obtain a Chinese medicinal filtrate with good kidney-tonifying and bone-strengthening and muscle-relaxing effects.

[0064] In some optional embodiments, the decoction time of the first round of decoction is ≥ 1 h, and the weight m8 of the water used in the first round of decoction and the weight m9 of the mixed Chinese medicinal material satisfy the relationship: m8:m9=(10-11):1; and / or

[0065] The decoction time of the second round of decoction is ≥ 1 h, and the weight m10 of the water used in the second round of decoction and the weight m9 of the mixed Chinese medicinal raw materials satisfy the relationship: m10:m9=(9-10):1;

[0066] In these embodiments, the decoction time of the first round of decoction can be ≥1h, and the weight m8 of the water used in the first round of decoction and the weight m9 of the mixed Chinese medicinal raw materials can satisfy the relationship: m8:m9=(10~11):1, and the effective ingredients of the mixed Chinese medicinal raw materials can be fully precipitated through the first round of decoction; in addition, the decoction time of the second round of decoction can be ≥1h, and the weight m10 of the water used in the second round of decoction and the weight m9 of the mixed Chinese medicinal raw materials can satisfy the relationship: m10:m9=(9~10):1, and the effective ingredients of the mixed Chinese medicinal raw materials can be effectively and fully precipitated through the second round of decoction to obtain a Chinese medicine filtrate with good kidney-tonifying and bone-strengthening and muscle-relaxing effects.

[0067] The weight m8 of water used in the first round of decoction and the weight m9 of the mixed Chinese medicinal materials can satisfy the relationship: m8:m9=10:1, 10.1:1, 10.2:1, 10.3:1, 10.4:1, 10.5:1, 10.6:1, 10.7:1, 10.8:1, 10.9:1 or 11:1.

[0068] The weight m10 of water used in the second round of decoction and the weight m9 of the mixed Chinese medicinal materials can satisfy the relationship: m10:m9=9:1, 9.1:1, 9.2:1, 9.3:1, 9.4:1, 9.5:1, 9.6:1, 9.7:1, 9.8:1, 9.9:1 or 10:1.

[0069] In some optional embodiments, the endpoint relative density of the reduced pressure concentration is 1.05 to 1.10;

[0070] In these embodiments, the relative density at the end point of reduced pressure concentration can be 1.05 to 1.10, and most of the water in the traditional Chinese medicine filtrate can be removed to finally obtain a traditional Chinese medicine composition paste containing a large amount of effective ingredients.

[0071] The endpoint relative density of the reduced pressure concentration may be 1.05, 1.06, 1.07, 1.08, 1.09 or 1.10.

[0072] It should be noted that the relative density at the endpoint of reduced pressure concentration can be measured at 60°C.

[0073] Based on a general inventive concept, an embodiment of the present application provides a traditional Chinese medicine preparation having the effects of tonifying the kidney and strengthening the bones and relaxing the tendons and activating the collaterals, wherein the traditional Chinese medicine preparation includes the traditional Chinese medicine composition.

[0074] The Chinese medicine preparation is realized based on the above-mentioned Chinese medicine composition. The specific composition of the Chinese medicine composition can refer to the above-mentioned embodiment. Since the Chinese medicine preparation adopts part or all of the technical solutions of the above-mentioned embodiments, it has at least all the beneficial effects brought by the technical solutions of the above-mentioned embodiments, which will not be described one by one here.

[0075] Figure 3 A schematic diagram of a method for preparing a Chinese medicine preparation having the effects of tonifying the kidney and strengthening the bones and relaxing the tendons and activating the collaterals provided in an embodiment of the present application is shown as an example

[0076] Based on a general inventive concept, such as Figure 3 As shown, the present application embodiment provides a method for preparing the traditional Chinese medicine preparation, the method comprising:

[0077] S1. The dextrin and the Chinese medicine composition are mixed and dried several times to obtain Chinese medicine preparation particles;

[0078] Among them, the weight m11 of the dextrin and the weight m12 of the traditional Chinese medicine composition satisfy the relationship: m11:m12=(6.5-13.5):100.

[0079] This method is a method for preparing the above-mentioned Chinese medicine preparation. The specific composition of the Chinese medicine preparation can refer to the above-mentioned embodiment. Since this method adopts part or all of the technical solutions of the above-mentioned embodiment, it at least has all the beneficial effects brought by the technical solutions of the above-mentioned embodiment, which will not be repeated here one by one.

[0080] It should be noted that the dextrin and the traditional Chinese medicine composition can be mixed twice, wherein the weight ratio of dextrin and the traditional Chinese medicine composition in the first mixing stage can be 5:100, and in the second mixing stage the weight ratio of dextrin and the traditional Chinese medicine composition can be (1.5-8.5):100.

[0081] The weight m11 of the dextrin and the weight m12 of the traditional Chinese medicine composition can satisfy the relationship: m11:m12=6.5:100, 7.0:100, 7.5:100, 8.0:100, 8.5:100, 9.0:100, 9.5:100, 10.0:100, 10.5:100, 11.0:100, 11.5:100, 12.0:100, 12.5:100, 13.0:100 or 13.5:100.

[0082] The present application is further described below in conjunction with specific examples. The experimental methods in the following examples that do not specify specific conditions are usually measured according to industry standards; if there are no corresponding industry standards, they are carried out according to common international standards, conventional conditions, or conditions recommended by the manufacturer.

[0083] Example 1

[0084] A Chinese medicine composition with the effects of tonifying the kidney and strengthening the bones and relaxing the tendons and activating the collaterals. The raw materials of the Chinese medicine composition include: roasted epimedium, prepared rehmannia root, eucommia bark, processed polygonum multiflorum, cynomorium songaricum, scalded drynaria root and angelica sinensis. The weight m1 of the roasted epimedium, the weight m2 of the prepared rehmannia root, the weight m3 of the eucommia bark, the weight m4 of the processed polygonum multiflorum, the weight m5 of the cynomorium songaricum, the weight m6 of the scalded drynaria root and the weight m7 of the angelica sinensis satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=335:420:335:420:420:335:335.

[0085] like Figure 2 As shown, a method for preparing the Chinese medicine composition comprises:

[0086] S1. Mix roasted epimedium, Rehmannia root, Eucommia ulmoides, processed Polygonum multiflorum, Cynomorium songaricum, scalded Drynaria and Angelica sinensis to obtain a mixed Chinese medicine raw material;

[0087] S201. The mixed Chinese medicinal raw materials are subjected to a first round of decoction using water to obtain a first Chinese medicinal decoction and a decoction residue;

[0088] S202. Using the water to perform a second round of decoction on the decoction residue to obtain a second Chinese medicine decoction;

[0089] S203. The first Chinese medicine decoction and the second Chinese medicine decoction are combined, and then the combined mixed decoction is filtered to obtain a Chinese medicine filtrate;

[0090] S3. Concentrate the traditional Chinese medicine filtrate under reduced pressure to obtain a clear paste of the traditional Chinese medicine composition.

[0091] The decoction time of the first round of decoction is 1 hour, and the weight m8 of the water used in the first round of decoction and the weight m9 of the mixed Chinese medicinal raw materials satisfy the relationship: m8:m9=11:1;

[0092] The decoction time of the second round of decoction is 1 hour. The weight m10 of water used in the second round of decoction and the weight m9 of the mixed Chinese medicinal materials satisfy the relationship: m10:m9=9:1.

[0093] The Chinese medicine preparation is prepared based on the above-mentioned Chinese medicine composition clear paste and dextrin, and the specific process is as follows:

[0094] S1. The dextrin and the Chinese medicine composition are mixed and dried several times to obtain Chinese medicine preparation particles;

[0095] Among them, the weight m11 of the dextrin and the weight m12 of the traditional Chinese medicine composition satisfy the relationship: m11:m12=10.5:1.

[0096] Example 2

[0097] Based on the contents disclosed in Example 1, the following modifications are further made:

[0098] The weight m1 of roasted epimedium, the weight m2 of prepared rehmannia root, the weight m3 of eucommia bark, the weight m4 of processed polygonum multiflorum, the weight m5 of cynomorium songaricum, the weight m6 of scalded drynaria root and the weight m7 of angelica sinensis satisfy the relationship:

[0099] m1:m2:m3:m4:m5:m6:m7=300:465:365:465:375:365:365.

[0100] Example 3

[0101] Based on the contents disclosed in Example 1, the following modifications are further made:

[0102] The weight m1 of roasted epimedium, the weight m2 of prepared rehmannia root, the weight m3 of eucommia bark, the weight m4 of processed polygonum multiflorum, the weight m5 of cynomorium songaricum, the weight m6 of scalded drynaria root and the weight m7 of angelica sinensis satisfy the relationship:

[0103] m1:m2:m3:m4:m5:m6:m7=365:375:300:375:465:300:300.

[0104] Example 4

[0105] Based on the contents disclosed in Example 1, the following modifications are further made:

[0106] The weight m1 of roasted epimedium, the weight m2 of prepared rehmannia root, the weight m3 of eucommia bark, the weight m4 of processed polygonum multiflorum, the weight m5 of cynomorium songaricum, the weight m6 of scalded drynaria root and the weight m7 of angelica sinensis satisfy the relationship:

[0107] m1:m2:m3:m4:m5:m6:m7=265:505:405:335:505:405:265.

[0108] Example 5

[0109] Based on the contents disclosed in Example 1, the following modifications are further made:

[0110] The weight m1 of roasted epimedium, the weight m2 of prepared rehmannia root, the weight m3 of eucommia bark, the weight m4 of processed polygonum multiflorum, the weight m5 of cynomorium songaricum, the weight m6 of scalded drynaria root and the weight m7 of angelica sinensis satisfy the relationship:

[0111] m1:m2:m3:m4:m5:m6:m7=405:335:265:505:335:265:405.

[0112] Comparative Example 1

[0113] Based on the contents disclosed in Example 1, the following modifications are further made:

[0114] The weight m1 of roasted epimedium, the weight m2 of prepared rehmannia root, the weight m3 of eucommia bark, the weight m4 of processed polygonum multiflorum, the weight m5 of cynomorium songaricum, the weight m6 of scalded drynaria root and the weight m7 of angelica sinensis satisfy the relationship:

[0115] m1:m2:m3:m4:m5:m6:m7=500:550:200:420:420:335:250.

[0116] Comparative Example 2

[0117] Based on the contents disclosed in Example 1, the following modifications are further made:

[0118] The weight m1 of roasted epimedium, the weight m2 of prepared rehmannia root, the weight m3 of eucommia bark, the weight m4 of processed polygonum multiflorum, the weight m5 of cynomorium songaricum, the weight m6 of scalded drynaria root and the weight m7 of angelica sinensis satisfy the relationship:

[0119] m1:m2:m3:m4:m5:m6:m7=0:420:335:420:420:335:335.

[0120] Comparative Example 3

[0121] Based on the contents disclosed in Example 1, the following modifications are further made:

[0122] The weight m1 of roasted epimedium, the weight m2 of prepared rehmannia root, the weight m3 of eucommia bark, the weight m4 of processed polygonum multiflorum, the weight m5 of cynomorium songaricum, the weight m6 of scalded drynaria root and the weight m7 of angelica sinensis satisfy the relationship:

[0123] m1:m2:m3:m4:m5:m6:m7=335:0:335:420:420:335:335.

[0124] Comparative Example 4

[0125] Based on the contents disclosed in Example 1, the following modifications are further made:

[0126] The weight m1 of roasted epimedium, the weight m2 of prepared rehmannia root, the weight m3 of eucommia bark, the weight m4 of processed polygonum multiflorum, the weight m5 of cynomorium songaricum, the weight m6 of scalded drynaria root and the weight m7 of angelica sinensis satisfy the relationship:

[0127] m1:m2:m3:m4:m5:m6:m7=335:420:0:420:420:335:335.

[0128] Comparative Example 5

[0129] Based on the contents disclosed in Example 1, the following modifications are further made:

[0130] The weight m1 of roasted epimedium, the weight m2 of prepared rehmannia root, the weight m3 of eucommia bark, the weight m4 of processed polygonum multiflorum, the weight m5 of cynomorium songaricum, the weight m6 of scalded drynaria root and the weight m7 of angelica sinensis satisfy the relationship:

[0131] m1:m2:m3:m4:m5:m6:m7=335:420:335:0:420:335:335.

[0132] Comparative Example 6

[0133] Based on the contents disclosed in Example 1, the following modifications are further made:

[0134] The weight m1 of roasted epimedium, the weight m2 of prepared rehmannia root, the weight m3 of eucommia bark, the weight m4 of processed polygonum multiflorum, the weight m5 of cynomorium songaricum, the weight m6 of scalded drynaria root and the weight m7 of angelica sinensis satisfy the relationship:

[0135] m1:m2:m3:m4:m5:m6:m7=335:420:335:420:0:335:335.

[0136] Comparative Example 7

[0137] Based on the contents disclosed in Example 1, the following modifications are further made:

[0138] The weight m1 of roasted epimedium, the weight m2 of prepared rehmannia, the weight m3 of eucommia, the weight m4 of processed polygonum multiflorum, the weight m5 of cynomorium songaricum, the weight m6 of scalded drynaria and the weight m7 of angelica satisfy the relationship:

[0139] m1:m2:m3:m4:m5:m6:m7=335:420:335:420:420:0:335.

[0140] Comparative Example 8

[0141] Based on the contents disclosed in Example 1, the following modifications are further made:

[0142] The weight m1 of roasted epimedium, the weight m2 of prepared rehmannia root, the weight m3 of eucommia bark, the weight m4 of processed polygonum multiflorum, the weight m5 of cynomorium songaricum, the weight m6 of scalded drynaria root and the weight m7 of angelica sinensis satisfy the relationship:

[0143] m1:m2:m3:m4:m5:m6:m7=335:420:335:420:420:335:0.

[0144] Comparative Example 9

[0145] Based on the contents disclosed in Example 1, the following modifications are further made:

[0146] Morinda officinalis is used to replace Cynomorium songaricum, and the Chinese medicine composition satisfies: the weight m1 of roasted Epimedium, the weight m2 of Rehmannia glutinosa, the weight m3 of Eucommia ulmoides, the weight m4 of processed Polygonum multiflorum, the weight m5 of Morinda officinalis, the weight m6 of boiled Drynaria fortunei and the weight m7 of Angelica sinensis satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=335:420:335:420:420:335:335.

[0147] Related experiments and effect data:

[0148] Several SD rats weighing 240g to 260g were selected, half of which were male and half were female. Chloral hydrate was injected intraperitoneally at a dose of 0.5mL / 100g for anesthesia, and then the left knee joint cavity of the rat was punctured, and the needle was inserted from the outside and below the patella. After entering the joint cavity, a mixed solution of 4% papain solution and 0.03moL / L cysteine ​​solution with a volume ratio of 1:1 was injected into the joint cavity at a dose of 0.2mL / kg. The injection was repeated once every other day and continued for 2 weeks. Another 8 rats were taken as the sham operation group (blank group), and 0.2mL / kg of normal saline was injected after puncture of the left knee joint cavity. The rest of the operation was the same as above. The limb activity of the rats in the modeling group and the presence of infection, swelling, etc. in the joints were observed daily. The occurrence of swelling and flexion and extension dysfunction indicated that the modeling was successful.

[0149] The modeled rats were then randomly divided into 15 groups (including the model group but not the sham operation group) according to their weight, which were grouped according to each embodiment and comparative example and the model group, and the number of rats in each group was 8. The drug administration group was gavaged with the corresponding Chinese medicine composition at a dose of 9 g crude drug / kg, and the administration volume was 20 mL / kg. The model group and the sham operation group were gavaged with the same volume of normal saline, once a day, for 4 consecutive weeks.

[0150] 24 hours after the last administration, blood samples were collected from rats and centrifuged at 2000 r / min for 15 min to obtain serum. The IL-1β level was determined by enzyme-linked immunosorbent assay. The results are shown in Table 1.

[0151] Table 1 IL-1β levels of various examples and comparative examples

[0152] Group Number of animals IL-1β (ng / L) Sham operation group 8 37.16±6.49 Model Group 8 <![CDATA[75.47±15.28 * ]]> Example 1 Group 8 <![CDATA[40.03±6.85 # ]]> Example 2 Group 8 <![CDATA[41.35±6.67 # ]]> Example 3 Group 8 <![CDATA[41.72±7.02 # ]]> Example 4 Group 8 <![CDATA[43.20±8.21 # ]]> Example 5 Group 8 <![CDATA[43.65±7.79 # ]]> Comparative Example 1 8 <![CDATA[55.54±9.62 #△ ]]> Comparative Example 2 8 <![CDATA[65.49±11.65 △ ]]> Comparative Example 3 8 <![CDATA[63.38±12.48 △ ]]> Comparative Example 4 8 <![CDATA[63.50±9.77 △ ]]> Comparative Example 5 8 <![CDATA[61.78±13.02 △ ]]> Comparative Example 6 8 <![CDATA[62.06±10.28 △ ]]> Comparative Example 7 8 <![CDATA[61.65±11.52 △ ]]> Comparative Example 8 8 <![CDATA[61.59±10.43 △ ]]> Comparative Example 9 8 <![CDATA[58.88±10.57 #△ ]]>

[0153] Note: Compared with the sham operation group, * P<0.05; compared with the model group, # P<0.05; compared with the Example 1 group, △ P<0.05.

[0154] As can be seen from Table 1, the Chinese medicine composition with the effects of tonifying the kidney and strengthening the bones and relaxing the muscles and activating the collaterals provided in the embodiment of the present application can effectively improve the expression level of IL-1β in the blood of rats to below 50 ng / L, which shows that the Chinese medicine composition has good kidney-tonifying and bone-strengthening effects.

[0155] In summary, the embodiment of the present application provides a traditional Chinese medicine composition with the effects of tonifying the kidney and strengthening the bones and relaxing the muscles and activating the collaterals. The traditional Chinese medicine composition uses roasted epimedium, prepared rehmannia, eucommia, processed polygonum multiflorum, cynomorium songaricum, scalded drynaria and angelica as the formula, and only seven traditional Chinese medicines are used for compatibility, and cynomorium songaricum is used to balance and improve the kidney-tonifying and bone-strengthening and muscle-relaxing and collateral-activating effects of the remaining traditional Chinese medicine compositions, thereby ultimately improving the kidney-tonifying and bone-strengthening effects of the traditional Chinese medicine composition with fewer traditional Chinese medicine components.

[0156] In addition, the embodiment of the present application provides a traditional Chinese medicine agent with the effects of tonifying the kidney and strengthening the bones and relaxing the muscles and activating the collaterals. It has good effects of tonifying the kidney and strengthening the bones and relaxing the muscles and activating the collaterals, and can be used for the treatment or relief of symptoms such as osteoarthritis, bone hyperplasia, cervical spondylosis, low back and knee pain caused by bone spurs, and limb numbness.

[0157] The above is only a specific implementation of the present application, so that those skilled in the art can understand or implement the present application. It will be apparent to those skilled in the art that various modifications to these embodiments are possible, and the general principles defined in the present application can be implemented in other embodiments without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to these embodiments shown in the present application, but will conform to the widest scope consistent with the principles and novel features applied for by the present application.

Claims

1. A Chinese medicine composition having the effects of tonifying the kidney and strengthening bones and relaxing tendons and activating collaterals, characterized in that: The raw materials of the Chinese medicine composition include: roasted epimedium, prepared rehmannia root, eucommia bark, processed polygonum multiflorum, cynomorium songaricum, scalded drynaria root and angelica sinensis. The weight m1 of the roasted epimedium, the weight m2 of the prepared rehmannia root, the weight m3 of the eucommia bark, the weight m4 of the processed polygonum multiflorum, the weight m5 of the cynomorium songaricum, the weight m6 of the scalded drynaria root and the weight m7 of the angelica sinensis satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=(265-405):(335-505):(265-405):(335-505):(335-505):(265-405):(265-405).

2. The Chinese medicine composition according to claim 1, characterized in that: The weight m1 of the roasted Epimedium, the weight m2 of the Rehmannia root, the weight m3 of the Eucommia bark, the weight m4 of the processed Polygonum multiflorum, the weight m5 of the Cynomorium songaricum, the weight m6 of the scalded Drynaria fortunei and the weight m7 of the Angelica sinensis satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=(265-405):(335-505):(265-405):(335-505):(375-465):(265-405):(265-405).

3. The Chinese medicine composition according to claim 1 or 2, characterized in that: The weight m1 of the roasted Epimedium, the weight m2 of the Rehmannia root, the weight m3 of the Eucommia bark, the weight m4 of the processed Polygonum multiflorum, the weight m5 of the Cynomorium songaricum, the weight m6 of the scalded Drynaria fortunei and the weight m7 of the Angelica sinensis satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=(300~365):(375~465):(300~365):(375~465):(375~465):(300~365):(300~365).

4. The Chinese medicine composition according to claim 3, characterized in that: The weight m1 of the roasted Epimedium, the weight m2 of the Rehmannia root, the weight m3 of the Eucommia ulmoides, the weight m4 of the processed Polygonum multiflorum, the weight m5 of the Cynomorium songaricum, the weight m6 of the scalded Drynaria rhizome and the weight m7 of the Angelica sinensis satisfy the relationship: m1:m2:m3:m4:m5:m6:m7=335:420:335:420:420:335:

335.

5. A method for preparing the Chinese medicine composition according to any one of claims 1 to 4, characterized in that: The method comprises: Mixing roasted epimedium, prepared rehmannia root, eucommia bark, processed polygonum multiflorum, cynomorium songaricum, scalded drynaria and angelica sinensis to obtain a mixed Chinese medicine raw material; Using water to decoct the mixed Chinese medicinal raw materials at least twice, and then combining and filtering the Chinese medicinal decoctions obtained by decocting to obtain a Chinese medicinal filtrate; The traditional Chinese medicine filtrate is concentrated under reduced pressure to obtain a traditional Chinese medicine composition paste.

6. The method according to claim 5, characterized in that The method of decocting the mixed Chinese medicinal raw materials at least twice with water, and then combining and filtering the Chinese medicinal decoctions obtained by decocting to obtain the Chinese medicinal filtrate comprises the following steps: Using water to perform a first round of decoction on the mixed Chinese medicinal raw materials to obtain a first Chinese medicinal decoction liquid and a decoction residue respectively; Using the water to perform a second round of decoction on the decoction residue to obtain a second Chinese medicine decoction; The first Chinese medicine decoction and the second Chinese medicine decoction are combined, and then the combined mixed decoction is filtered to obtain a Chinese medicine filtrate.

7. The method according to claim 6, characterized in that The decoction time of the first round of decoction is ≥ 1 h, and the weight m8 of the water used in the first round of decoction and the weight m9 of the mixed Chinese medicinal raw materials satisfy the relationship: m8:m9=(10-11):1; and / or The decoction time of the second round of decoction is ≥1h, and the weight m10 of the water used in the second round of decoction and the weight m9 of the mixed Chinese medicinal raw materials satisfy the relationship: m10:m9=(9-10):

1.

8. The method according to claim 5, characterized in that The endpoint relative density of the reduced pressure concentration is 1.05 to 1.

10.

9. A Chinese medicine preparation having the effects of tonifying the kidney and strengthening bones and relaxing tendons and activating collaterals, characterized in that: The Chinese medicine preparation comprises the Chinese medicine composition according to any one of claims 1 to 4.

10. A method for preparing the traditional Chinese medicine preparation according to claim 9, characterized in that: The method comprises: Mixing and drying dextrin and the traditional Chinese medicine composition for multiple times to obtain traditional Chinese medicine preparation particles; Among them, the weight m11 of the dextrin and the weight m12 of the traditional Chinese medicine composition satisfy the relationship: m11:m12=(6.5-13.5):100.

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