Implantable nano ultrasonic cavitation treatment particle

Abstract

The invention relates to an implantable nano ultrasonic cavitation treatment particle which comprises a first hemisphere, a middle-section sphere and a second hemisphere, and the first hemisphere and the second hemisphere are connected through the middle-section sphere to form a complete miniature spherical particle structure; a miniature ultrasonic vibration assembly is arranged in the middle-section sphere, a drive control assembly is arranged in the first hemisphere, and a first battery is further arranged in the second hemisphere. The nano-scale volume and the specific spherical shape are adopted, so that the nano-scale ultrasonic wave therapeutic apparatus can be more easily implanted into an affected part in a human body, people do not have foreign body sensation, daily life and work of people are not affected, the cavitation effect of ultrasonic waves can be intensively acted on the affected part, cells of lesion tissues are ensured to be killed, the therapeutic effect is greatly improved, and the treatment cost is reduced. The injury to human organs caused by excessive medication in the traditional medical means is effectively avoided. The product can be used for a long time in a human body only by one-time implantation, so that a patient can be subjected to ultrasonic treatment at regular intervals at home without going to and from a hospital frequently, the number of times for the patient to go to and go to the hospital is greatly reduced, time and money are saved for the patient, and the health of people is improved.

Description

Technical Field

[0001] The invention relates to the field of ultrasonic therapeutic instruments, in particular to an implantable nano ultrasonic cavitation therapeutic particle. Background Art

[0002] Ultrasonic therapy devices use ultrasound as a treatment source, focusing ultrasound outside the body on the diseased tissue inside the body, causing the temperature of the diseased tissue inside the body to rise rapidly, producing biological effects under the mechanical effect, thermal penetration and cavitation, thereby killing and ablating the diseased tissue cells, preventing the diseased tissue cells from spreading and achieving the purpose of treatment; at the same time, the ultrasonic cavitation effect can also promote blood circulation, accelerate metabolism, and regenerate healthy cell tissues, thereby achieving the purpose of treating diseased tissues.

[0003] In the existing ultrasonic therapeutic devices, for example, a technical solution named "A real-time positioning low-energy ultrasonic therapeutic device" is disclosed in Chinese patent literature with patent application number 202010504927.4. The solution mainly includes a therapeutic device host and an ultrasonic probe, wherein the therapeutic device host is composed of a supporting device, a control panel, an image display screen, and an ultrasonic generating device, and the ultrasonic probe is connected to the ultrasonic generating device. During treatment, medical staff places the ultrasonic probe on the surface of the human body, so that the ultrasonic probe can output ultrasonic waves to the human body and perform ultrasonic treatment on the lesion. However, in actual applications, this type of ultrasonic therapeutic device still has the following shortcomings: First, this type of ultrasonic therapeutic device is an external therapeutic device, and the irradiation area of ​​the ultrasonic probe is large. During the treatment process, the healthy tissues around the diseased area will also be affected by the ultrasonic cavitation of the same frequency, which will inevitably cause damage to the healthy parts, prone to intermittent colic, and in severe cases, it is easy to cause contusion and laceration of the organs. Therefore, in order to reduce damage to healthy tissues, each ultrasonic treatment is usually short, resulting in very little therapeutic effect on the diseased tissue, greatly prolonging the treatment time of the patient.

[0004] Second, this type of ultrasonic therapeutic device requires professional medical staff in the hospital to know how to operate it. Patients can only go back and forth to the hospital frequently for regular treatment, and the time and money costs are also very high.

[0005] Therefore, the applicant believes that it is very necessary to design an implantable nano-ultrasonic cavitation therapeutic particle that can be implanted into the human body, reduce damage to healthy parts, and can be used for regular treatment without frequent trips to the hospital. Summary of the invention

[0006] The purpose of the present invention is to solve the above-mentioned problems and shortcomings, and to provide an implantable nano-ultrasonic cavitation therapeutic particle. The implantable nano-ultrasonic cavitation therapeutic particle can be more easily implanted into the diseased part inside the human body because of its nano-level volume and specific shape, so that people do not feel a foreign body. The cavitation efficiency of the ultrasonic wave is concentrated and directly acts on the diseased part, ensuring that the diseased tissue cells are killed, greatly improving the therapeutic efficacy, and effectively avoiding the damage to human organs caused by excessive use of traditional medical methods; the micro-ultrasonic vibration component can not only perform ultrasonic vibration work, but also has wireless charging function and wireless control function. It only needs to be implanted once and can be used for a long time inside the human body, so that patients can also undergo regular ultrasonic treatment at home without frequent travel to and from the hospital, greatly reducing the number of times patients travel to and from the hospital and the time and money costs.

[0007] The technical solution of the present invention is implemented as follows: an implantable nano-ultrasonic cavitation therapeutic particle, which is characterized in that it includes a first hemisphere, a middle sphere, and a second hemisphere, and the first hemisphere and the second hemisphere are connected through the middle sphere to form a complete micro-spherical particle structure; a micro-ultrasonic vibration component is provided in the middle sphere, and the micro-ultrasonic vibration component includes a sliding block with a permanent magnet block, a spring arranged at both ends of the sliding block for buffering and rebounding, and a driving coil that cooperates with the permanent magnet block to produce a magnetic drive effect; a drive control component is provided in the first hemisphere, and the drive control component includes a circuit board with a wireless communication module, a wireless charging receiving coil electrically connected to the circuit board, and the drive coil is electrically connected to the circuit board to drive the micro-ultrasonic vibration component to work; the second hemisphere is also provided with a first battery electrically connected to the circuit board.

[0008] Preferably, a first positioning pin and a first positioning hole which are nested with each other are provided between the first hemisphere and the middle sphere, and a second positioning pin and a second positioning hole which are nested with each other are provided between the second hemisphere and the middle sphere.

[0009] Preferably, a first sealing ring is provided between the first hemisphere and the middle sphere, and a second sealing ring is provided between the second hemisphere and the middle sphere.

[0010] Preferably, the first hemisphere or the second hemisphere is also provided with a camera module or a sensor module electrically connected to the circuit board.

[0011] Preferably, a plurality of guide grooves arranged in a crisscross pattern are provided on the surface of the micro-spherical particle structure.

[0012] Preferably, the present invention also includes an in vitro controller; the in vitro controller includes an outer shell, a main control circuit arranged in the outer shell and transmitting control signals to and from the wireless communication module, and a control display component arranged on the outer shell, wherein the control display component is electrically connected to the main control circuit.

[0013] Preferably, the control display component includes a display screen and control buttons, and the display screen and control buttons are electrically connected to the main control circuit respectively.

[0014] Preferably, the outer shell is also provided with a wireless charging transmitting coil electrically connected to the main control circuit, and the wireless charging transmitting coil transmits an electromagnetic field to the wireless charging receiving coil, and the wireless charging receiving coil receives the electromagnetic field and converts it into current to charge the first battery.

[0015] Preferably, a second battery electrically connected to the main control circuit is further provided in the outer shell, and a charging interface electrically connected to the second battery is further provided on the outer shell.

[0016] Preferably, a DC electromagnet electrically connected to the main control circuit is also provided in the outer shell, and a micro magnet block magnetically matched with the DC electromagnet is also provided on the micro spherical particle structure; an embedding groove is provided on the surface of the micro spherical particle structure, and the micro magnet block is embedded in the embedding groove.

[0017] Beneficial effects of the present invention: Since the present invention adopts a nano-scale spherical design, its size is extremely small and its shape is specific, so it can be more easily implanted into the diseased part inside the human body, which not only makes people feel no foreign body, and does not produce adverse reactions and discomfort, but also after implantation into the diseased part, the cavitation efficiency of the ultrasonic wave is directly concentrated on the diseased part, so that the loss of ultrasonic wave energy efficiency is extremely small, ensuring that the diseased tissue cells are killed and obtaining a better treatment effect. At the same time, when the ultrasonic wave is working, the ultrasonic cavitation effect generated can promote blood circulation, relieve soft tissue, reduce swelling and eliminate inflammation, improve the nutritional status of tissues, destroy thrombus blocks, ablate the formation of thrombus blocks and diseased tissues, and has the effect of helping the inner wall of blood vessels to repair themselves, thereby prolonging human life. In addition, the ultrasonic wave does not need to pass through the human skin, which can greatly reduce the loss of ultrasonic wave and improve the treatment effect. At the same time, the micro-spherical particle structure of the present invention is provided with a drive control component and a first battery, which can not only drive the micro-ultrasonic vibration component to work, but also has a wireless charging function and a wireless control function, so that only one implantation is needed to enable the ultrasonic cavitation therapy particles to be used for a long time inside the human body, and professional medical staff can set the parameters of the ultrasonic energy intensity and the working time in the circuit board, so that patients can also regularly perform ultrasonic therapy at home, without frequent commuting to the hospital, greatly reducing the number of commuting to the hospital and the time and money cost spent by the patient, and at the same time, it can also enable the patient to significantly reduce the amount of medicine taken, greatly reducing the harm to human health caused by the side effects of the medicine, which is conducive to prolonging people's life. In addition, the micro-spherical particle structure is composed of a first hemisphere, a middle sphere, and a second hemisphere, so that the three have independent and sufficient space for the drive control component, the micro-ultrasonic vibration component, and the first battery to accommodate and install, which is not only more conducive to production and manufacturing, but also enables each space to be reasonably utilized, and there will be no mutual obstruction during work, making its structure more compact and reliable. In addition, the nano-scale sphere design adopted in this solution allows it to be implanted into the patient's body through surgery or injection, and the surgical wound is extremely small, so that the patient's life and work are not affected after the operation, which greatly reduces the patient's pain. The product of this solution can be implanted into the tumor site of the human body, the inside of the blood vessel or the side wall of the interlayer of the blood vessel, the gallbladder and other diseased human organs for treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the three-dimensional structure of the micro-spherical particle structure of the present invention.

[0019] Figure 2 It is a schematic diagram of the partially disassembled structure of the micro-spherical particle structure of the present invention.

[0020] Figure 3 This is one of the schematic diagrams of the split structure of the micro-spherical particle structure of the present invention.

[0021] Figure 4This is the second schematic diagram of the split structure of the micro-spherical particle structure of the present invention.

[0022] Figure 5 It is a schematic diagram of the split structure of the middle sphere of the present invention.

[0023] Figure 6 It is a schematic diagram of the split structure of the second hemisphere of the present invention.

[0024] Figure 7 It is a schematic diagram of the three-dimensional structure of the in vitro controller of the present invention.

[0025] Figure 8 It is a schematic diagram of the split structure of the in vitro controller of the present invention.

[0026] Fig. 9 It is a schematic diagram of the use status of the micro-spherical particle structure and the in vitro controller of the present invention. DETAILED DESCRIPTION

[0027] like Figure 1 and Figure 3 As shown, the implantable nano ultrasonic cavitation therapeutic particles of the present invention include a first hemisphere 1, a middle sphere 2, and a second hemisphere 3. The first hemisphere 1 and the second hemisphere 3 are connected through the middle sphere 2 to form a complete micro spherical particle structure 100; Figures 4 to 6 As shown, a miniature ultrasonic vibration component 20 is provided in the middle sphere 2, and the miniature ultrasonic vibration component 20 includes a sliding block 22 with a permanent magnet block 21, springs 23 for buffering and rebounding arranged at both ends of the sliding block 22, and a driving coil 24 for cooperating with the permanent magnet block 21 to produce a magnetic driving effect; a driving control component 10 is provided in the first hemisphere 1, and the driving control component 10 includes a circuit board 12 with a wireless communication module 11, and a wireless charging receiving coil 13 electrically connected to the circuit board 12, and the driving coil 24 is electrically connected to the circuit board 12 to drive the miniature ultrasonic vibration component 20 to work; a first battery 30 electrically connected to the circuit board 12 is also provided in the second hemisphere 3.

[0028] The working principle of the micro ultrasonic vibration component 20: the first battery 30 supplies power to the driving coil 24 through the circuit board 12. The current flows into the driving coil 24 to generate a magnetic field, driving the permanent magnet block 21 and the sliding block 22 to reciprocate, thereby generating high-frequency vibrations. These high-frequency vibrations propagate in media such as gas, liquid, and solid to form ultrasonic waves.

[0029] This solution allows the user to send an on / off signal to the wireless communication module 11 through a wireless communication device, so that the circuit board 12 controls the start and stop of the entire micro ultrasonic vibration assembly 20. The wireless communication module 11 is an ultra-micro Bluetooth communication module or a WiFi communication module, etc., and is used to access a computer, a smart phone, a tablet computer and other devices, so as to realize the control, monitoring, data transmission and other operations of the implantable nano ultrasonic cavitation therapeutic particles.

[0030] In addition to using the aforementioned micro-ultrasonic vibration component 20 as an implementation scheme, the present invention can also be implemented by using a micro-ultrasonic transducer as an alternative, or by using a micro-ultrasonic vibration motor as an alternative.

[0031] In practical applications, the driving coil 24 , the wireless charging receiving coil 13 and the first battery 30 are all electrically connected to the circuit board 12 through the wire 200 , and the wireless communication module 11 is built into the circuit board 12 .

[0032] In order to facilitate the assembly and positioning of the first hemispherical body 1, the middle sphere 2 and the second hemispherical body 3 and improve the convenience of assembly, as shown in FIG. Figure 3 and Figure 4 As shown, a first locating pin 101 and a first locating hole 102 are provided between the first hemisphere 1 and the middle sphere 2, and a second locating pin 103 and a second locating hole 104 are provided between the second hemisphere 3 and the middle sphere 2. Specifically, the first locating pin 101 is arranged on the first hemisphere 1, and the first locating hole 102 is arranged on the middle sphere 2. Of course, the setting positions of the first locating pin 101 and the first locating hole 102 can also be interchanged, which can also play a role of nested positioning. Similarly, the second locating pin 103 is arranged on the second hemisphere 3, and the second locating hole 104 is arranged on the middle sphere 2. Of course, the setting positions of the second locating pin 103 and the second locating hole 104 can also be interchanged, which can also play a role of nested positioning. Through such a structural design, after being assembled together, the positions between each other will not be offset, thereby improving the accuracy of positioning. In practical applications, in order to ensure that the first hemisphere 1, the middle sphere 2 and the second hemisphere 3 can be firmly installed together and not easily loosened, the first hemisphere 1 and the middle sphere 2 are fixed together by welding, and the second hemisphere 3 and the middle sphere 2 are also fixed together by welding.

[0033] In order to improve the sealing performance and protect the electrical components inside the micro-spherical particle structure 100, such as Figure 3 and Figure 4As shown, a first sealing ring 105 is provided between the first hemisphere 1 and the middle sphere 2 , and a second sealing ring 106 is provided between the second hemisphere 3 and the middle sphere 2 .

[0034] In order to facilitate people to intuitively observe the operation of implantable nano-ultrasonic cavitation therapy particles in the human body and detect the condition of the affected part inside the human body, such as Figure 1 and Figure 4 As shown, the first hemisphere 1 or the second hemisphere 3 is also provided with a camera module or a sensor module 4 electrically connected to the circuit board 12. The specific selection of the camera module or the sensor module 4 can be selected according to the actual treatment situation. Preferably, in order to facilitate the electrical connection with the circuit board 12, the camera module or the sensor module 4 is also arranged on the first hemisphere 1. When in use, the camera module or the sensor module 4 is connected to the external display screen, smart phone, tablet computer, and computer through the wireless communication module 11 on the circuit board 12 to transmit the image information or sensor data to the outside world and present it.

[0035] In order to ensure that the micro-spherical particle structure 100 does not hinder the blood flow in the blood vessels after being implanted into the human body and ensure the normal flow of blood, Figure 1 As shown, a plurality of crisscross-arranged guide grooves 107 are also provided on the surface of the micro-spherical particle structure 100. This can prevent blood stasis after implantation, making the use safer and more reliable.

[0036] In order to conveniently control and monitor the working condition of the micro-spherical particle structure 100 inside the human body, Figure 7 As shown, the present invention further includes an in vitro controller 5; the in vitro controller 5 includes an outer shell 51, a main control circuit 52 disposed in the outer shell 51 and transmitting control signals to and from the wireless communication module 11, and a control display component 53 disposed on the outer shell 51, wherein the control display component 53 is electrically connected to the main control circuit 52. This makes it convenient to control the micro-spherical particle structure 100.

[0037] In order to further improve the structure of the control display component 53, as Figure 7 As shown, the control display component 53 includes a display screen 531 and a control button 532, and the display screen 531 and the control button 532 are electrically connected to the main control circuit 52. By setting the display screen 531, it is convenient to intuitively display the control page, image information, sensor data and other information. By setting the control button 532, the control operation can be convenient.

[0038] In order to facilitate charging the first battery 30, Figure 4 and Figure 8As shown, the outer shell 51 is also provided with a wireless charging transmitting coil 54 electrically connected to the main control circuit 52. The wireless charging transmitting coil 54 transmits an electromagnetic field to the wireless charging receiving coil 13. After receiving the electromagnetic field, the wireless charging receiving coil 13 converts it into current to charge the first battery 30.

[0039] In order to improve the portability of the external controller 5, the external controller 5 can be carried and used anytime and anywhere without being interfered by the distance of the wires. Figure 7 and Figure 8 As shown, a second battery 55 electrically connected to the main control circuit 52 is further disposed in the outer shell 51 , and a charging interface 56 electrically connected to the second battery 55 is further disposed on the outer shell 51 .

[0040] When the micro-spherical particle structure 100 is implanted into a human blood vessel for treating thrombosis, Figure 4 , Figure 8 and Fig. 9 As shown, the outer shell 51 is also provided with a DC electromagnet 57 electrically connected to the main control circuit 52, and the micro-spherical particle structure 100 is also provided with a micro-magnet block 108 magnetically matched with the DC electromagnet 57. The DC electromagnet 57 of the in vitro controller 5 applies a magnetic field with opposite magnetic poles to the micro-magnet block 108 of the micro-spherical particle structure 100 to drive the micro-spherical particle structure 100 to move in the human blood vessels, so that the micro-spherical particle structure 100 can move and advance in the blood vessels while performing high-frequency ultrasonic vibration. Moreover, due to the assistance of high-frequency ultrasonic vibration, the micro-spherical particle structure 100 has very little resistance to advance or retreat in the process of moving in the blood vessels, and can move and advance freely without impacting or damaging the inner wall of the blood vessels. The micro ultrasonic vibration component 20 is used to generate high-frequency ultrasonic vibrations, which causes the blood to produce ultrasonic cavitation effects, causing blood cells to move at high speed and producing micro friction movements between cells. The micro friction effect can change the volume of tissue cells, reduce swelling, change the permeability of membranes, promote the exchange of metabolic substances, change the function of cells, and improve the regeneration capacity of tissue cells. At the same time, the micro friction effect can consume blood clots and blood lipids in the blood. Long-term use can reduce the formation of blood clots and ensure the health of human blood vessels. Moreover, it can be placed in blood vessels for a long time without the need to clean and maintain the micro spherical particle structure 100, nor does it need to be repeatedly taken out and put in, which greatly reduces the number of muscle injuries to the human body and greatly reduces the pain of patients. This technical solution can be used not only for the cleaning and health care of human blood vessels, but also for ultrasonic chemical treatment of tracheal effusions in the human lungs, and ultrasonic cavitation treatment of the human stomach and intestines. In order to facilitate the installation and positioning of the micro magnet block 108, as Figure 2 As shown, an embedding groove 109 is provided on the surface of the micro-spherical particle structure 100 , and the micro-magnet block 108 is embedded in the embedding groove 109 .

[0041] In order to facilitate the user to quickly know the position of the wireless charging transmitting coil 54 and the DC electromagnet 57 in the external controller 5, as shown in FIG. Figure 8 As shown, a position indication mark 58 corresponding to the position of the wireless charging transmitting coil 54 and the DC electromagnet 57 is also provided on the outer surface of the outer shell 51 .

[0042] In practical applications, the diameter of the micro-spherical particle structure 100 is 1 mm to 2 mm.

[0043] In practical applications, the first hemisphere 1, the middle sphere 2 and the second hemisphere 3 can be made of materials with high strength and good corrosion resistance, such as stainless steel, nickel-titanium alloy or cobalt-chromium alloy.

[0044] Compared with the prior proposal entitled "A Wireless Magnetic Ultrasonic Cavitation Movement In-body Physiotherapy Robot Device" and patent application number CN202010722274.7, which was previously applied for by the applicant to the State Intellectual Property Office of China, this proposal has a smaller size, reaching the nanometer level, a simpler and more scientific structure, and less burden and impact on people for implantation and application, and is significantly more advanced.

Claims

1. An implantable nano ultrasonic cavitation therapeutic particle, characterized in that: It comprises a first hemisphere (1), a middle sphere (2), and a second hemisphere (3), wherein the first hemisphere (1) and the second hemisphere (3) are connected via the middle sphere (2) to form a complete micro-spherical particle structure (100); A micro ultrasonic vibration component (20) is provided in the middle sphere (2), and the micro ultrasonic vibration component (20) comprises a sliding block (22) with a permanent magnet block (21), spring pieces (23) arranged at both ends of the sliding block (22) for buffering and rebounding, and a driving coil (24) for cooperating with the permanent magnet block (21) to generate a magnetic driving effect; A drive control component (10) is provided in the first hemisphere (1), the drive control component (10) comprising a circuit board (12) with a wireless communication module (11), a wireless charging receiving coil (13) electrically connected to the circuit board (12), and the drive coil (24) is electrically connected to the circuit board (12) to drive the micro ultrasonic vibration component (20) to operate; The second hemisphere (3) is also provided with a first battery (30) electrically connected to the circuit board (12).

2. The implantable nano-ultrasonic cavitation therapeutic particles according to claim 1 are characterized in that: A first positioning pin (101) and a first positioning hole (102) which are nested together are provided between the first hemisphere (1) and the middle sphere (2), and a second positioning pin (103) and a second positioning hole (104) which are nested together are provided between the second hemisphere (3) and the middle sphere (2).

3. The implantable nano-ultrasonic cavitation therapeutic particles according to claim 1 are characterized by: A first sealing ring (105) is provided between the first hemisphere (1) and the middle sphere (2), and a second sealing ring (106) is provided between the second hemisphere (3) and the middle sphere (2).

4. The implantable nano-ultrasonic cavitation therapeutic particles according to claim 1 are characterized in that: The first hemisphere (1) or the second hemisphere (3) is also provided with a camera module or a sensor module (4) electrically connected to the circuit board (12).

5. The implantable nano-ultrasonic cavitation therapeutic particles according to claim 1 are characterized in that: A plurality of guide grooves (107) arranged in a crisscross pattern are also provided on the surface of the micro-spherical particle structure (100).

6. The implantable nano-ultrasonic cavitation therapeutic particles according to claim 1 are characterized by: The device also comprises an in vitro controller (5); the in vitro controller (5) comprises an outer shell (51), a main control circuit (52) arranged in the outer shell (51) and transmitting control signals to and from the wireless communication module (11), and a control display component (53) arranged on the outer shell (51), the control display component (53) being electrically connected to the main control circuit (52).

7. The implantable nano-ultrasonic cavitation therapeutic particles according to claim 6 are characterized by: The control display component (53) comprises a display screen (531) and a control button (532), and the display screen (531) and the control button (532) are electrically connected to the main control circuit (52) respectively.

8. The implantable nano-ultrasonic cavitation therapeutic particles according to claim 6 are characterized by: The outer shell (51) is also provided with a wireless charging transmitting coil (54) electrically connected to the main control circuit (52), and the wireless charging transmitting coil (54) transmits an electromagnetic field to the wireless charging receiving coil (13), and the wireless charging receiving coil (13) receives the electromagnetic field and converts it into current to charge the first battery (30).

9. The implantable nano-ultrasonic cavitation therapeutic particles according to claim 6, characterized in that: A second battery (55) electrically connected to the main control circuit (52) is also provided in the outer shell (51), and a charging interface (56) electrically connected to the second battery (55) is also provided on the outer shell (51).

10. The implantable nano-ultrasonic cavitation therapeutic particles according to claim 6, characterized in that: The outer shell (51) is further provided with a DC electromagnet (57) electrically connected to the main control circuit (52); the micro-spherical particle structure (100) is further provided with a micro-magnet block (108) magnetically matched with the DC electromagnet (57); an embedding groove (109) is provided on the surface of the micro-spherical particle structure (100), and the micro-magnet block (108) is embedded in the embedding groove (109).

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