Automatic production equipment for medical sterile coupling agent

Abstract

The present application relates to the technical field of coupling agent production, and discloses an automatic production device for medical sterile coupling agent, including a reactor, a stirring mechanism is arranged in the reactor, a feeding port, a detection port, an air inlet, an exhaust port, a discharge port and a return port are sequentially opened on the reactor body of the reactor, and electromagnetic valves are arranged one by one, the feeding port is used to add coupling agent raw materials, the detection port is used to insert the detection device, and the viscosity, wire drawing degree and pH acidity and alkalinity of the coupling agent are detected, the air inlet is connected to the air outlet of the pressurizing device, the exhaust port is connected to the air outlet of the vacuuming device, and the internal air pressure of the reactor is controlled by the pressurizing device and the vacuuming device. The coupling agent is repeatedly stirred by the stirring mechanism, and the internal air pressure of the reactor is controlled in cooperation with the pressurizing device and the vacuuming device, and the pressurizing device and the vacuuming device are alternately operated, thereby improving the quality of the product.

Description

Technical Field

[0001] The invention relates to the technical field of coupling agent production, in particular to automatic production equipment for medical sterile coupling agent. Background Art

[0002] With the rapid development of modern medical technology, the application of ultrasonic diagnosis in clinical medicine is becoming more and more extensive. As an indispensable medium in the process of ultrasonic examination, the quality and performance of medical sterile coupling agent have a critical impact on the clarity and accuracy of ultrasonic images and the reliability of diagnostic results.

[0003] The quality of medical sterile coupling agent products is closely related to its bubble density, impurity content, viscosity measurement, and wire drawing degree measurement. The presence of bubbles in the coupling agent will seriously interfere with the propagation of ultrasound, causing the ultrasonic signal to reflect, scatter, and refract when encountering bubbles, thereby forming a large number of artifacts on the ultrasound image, reducing the image quality and interfering with the doctor's accurate judgment of the condition. Traditional methods mostly use simple static or natural defoaming, which is inefficient and cannot effectively remove tiny bubbles. Since medical sterile coupling agent is a viscous substance with low fluidity, traditional stirring technology is also difficult to effectively eliminate the bubbles therein. At present, there is also a method of ultrasonic defoaming, but in the actual production process, if the ultrasonic parameters are not set properly, it may have a certain impact on the properties of the coupling agent, such as causing the local temperature to be too high and changing the viscosity of the coupling agent. Summary of the invention

[0004] In view of the deficiencies of the prior art, the present invention provides an automatic production device for a medical sterile coupling agent, which solves the problem that the existing medical sterile coupling agent production equipment is difficult to effectively remove bubbles.

[0005] To achieve the above objectives, the present invention is implemented through the following technical solutions: an automatic production device for medical sterile coupling agent, comprising a reactor, wherein a stirring mechanism is arranged in the reactor, and a feeding port, a detection port, an air inlet, an exhaust port, a discharge port and a return port are sequentially provided on the reactor body of the reactor, and electromagnetic valves are respectively provided in a one-to-one correspondence with the feeding port, the detection port, the air inlet, the exhaust port, the discharge port and the return port, wherein the feeding port is used for adding coupling agent raw materials, the detection port is used for inserting a detection device, and detecting the viscosity, wire drawing degree and pH value of the coupling agent, the air inlet is connected to the air outlet of a pressurizing device, the exhaust port is connected to the air suction port of a vacuuming device, and the pressure device is used to pressurize the coupling agent. The vacuum equipment is used to control the internal air pressure of the reactor. A bucket filter is arranged below the discharge port. The output end of the bucket filter is connected to the feed end of the visual inspection equipment. The visual inspection equipment is provided with two material output ends, one of which is connected to the return port through a material pump 1, and the other is connected to the feed end of the canning equipment through a material pump 2. When the visual inspection equipment detects that any one or more of the bubble density, impurities and transparency of the coupling agent are unqualified, the coupling agent is transported back to the reactor through the material pump 1. When the visual inspection equipment detects that the bubble density, impurities and transparency of the coupling agent are all qualified, the coupling agent is transported to the canning equipment through the material pump 2.

[0006] Preferably, the reactor adopts a double-layer jacket structure, a temperature control medium cavity is formed between the two layers, and the temperature control medium cavity is connected to the circulating temperature control device, so that the liquid medium circulates between the temperature control medium cavity and the circulating temperature control device.

[0007] Preferably, the stirring mechanism includes a stirring motor, the outer wall of the stirring motor is fixedly connected to the center of the upper cover of the reactor, the output end of the stirring motor passes through the upper cover of the reactor and is fixedly connected to a stirring shaft, the bottom of the stirring shaft is fixedly connected to a stirring blade, and the stirring motor is used to drive the stirring blade to rotate and push the coupling agent near the stirring blade to move toward the bottom of the reactor.

[0008] Preferably, the bottom wall of the reactor upper cover is fixedly connected to a guide tube via a support, the middle portion of the guide tube is a cylindrical structure, and the upper and lower portions are respectively trumpet-shaped and extend outward, the stirring blades are located at the lower part of the guide tube, and the upper opening of the guide tube is close to the coupling agent liquid surface and is located below the liquid surface.

[0009] Preferably, an internal thread is formed on the inner wall of the guide tube, the internal thread is a triangular thread with a thread angle of 55°, and the surface roughness of the internal thread is Ra0.8 - Ra1.6 μm.

[0010] Preferably, the middle portion of the guide tube is a cylindrical structure, and the upper and lower portions extend outward in a trumpet shape respectively.

[0011] Preferably, the guide tube is a cylindrical structure as a whole, and a vortex generator is provided in the middle of the guide tube (905).

[0012] Preferably, a filter screen is fixedly installed at the lower opening of the guide tube, and the filter mesh number of the filter screen is greater than the filter mesh number of the bucket filter.

[0013] Preferably, during the operation of the stirring mechanism, the pressurizing device and the vacuuming device are operated alternately in a cycle.

[0014] Preferably, a sterilization device is provided between the canning device and the visual inspection device, and the sterilization device is used to sterilize the coupling agent.

[0015] The present invention provides an automatic production device for medical sterile coupling agent. It has the following beneficial effects: The present invention repeatedly stirs the coupling agent through a stirring mechanism, and cooperates with a pressurizing device and a vacuuming device to control the internal air pressure of the reactor. The alternating operation of the pressurizing device and the vacuuming device causes the reactor to alternate between a high pressure environment and a near-vacuum environment. On the one hand, tiny bubbles are compressed under a high pressure environment, while allowing the gas dissolved therein to dissolve better under high pressure. On the other hand, the bubbles fully escape under a vacuum environment. At the same time, through the alternating changes of the two, a better degassing effect is achieved, so that there are very few bubbles remaining inside the coupling agent produced, thereby improving the quality of the product. At the same time, the special structure design of the guide tube is used to further improve the mixing efficiency and effect of the coupling agent, and further improve the bubble removal effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a front perspective view of an automatic production device for a medical sterile coupling agent of the present invention; Figure 2 A rear perspective view of an automatic production device for a medical sterile coupling agent according to the present invention; Figure 3 It is a front view of an automatic production device for a medical sterile coupling agent of the present invention; Figure 4 A top view of an automatic production device for a medical sterile coupling agent according to the present invention; Figure 5 It is a schematic diagram of the internal structure of the reactor in the present invention.

[0017] Among them, 10, reactor; 101, feed port; 102, detection port; 103, air inlet; 104, exhaust port; 105, discharge port; 106, return port; 107, temperature control medium chamber; 20, pressurizing equipment; 30, vacuum equipment; 40, bucket filter; 50, visual inspection equipment; 60, material pump 1; 70, material pump 2; 80, canning equipment; 901, stirring motor; 902, stirring shaft; 903, stirring blade; 904, pillar; 905, guide tube; 906, filter screen. DETAILED DESCRIPTION

[0018] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0019] Please see attached Figure 1 -Attached Figure 5 The embodiment of the present invention provides an automatic production device for a medical sterile coupling agent, including a reactor 10, wherein a stirring mechanism is arranged in the reactor 10, and a feeding port 101, a detection port 102, an air inlet 103, an exhaust port 104, a discharge port 105 and a return port 106 are sequentially provided on the reactor body of the reactor 10, and electromagnetic valves are arranged one by one respectively. The feeding port 101 is used to add coupling agent raw materials, and the detection port 102 is used to insert the detection device and detect the viscosity, wire drawing degree and pH value of the coupling agent. The air inlet 103 is connected to the air outlet of the pressurizing device 20, and the exhaust port 104 is connected to the air suction port of the vacuum pumping device 30. The internal air pressure of the reactor 10 is controlled by the pressurizing device 20 and the vacuum pumping device 30. During the operation of the stirring mechanism, The pressurizing device 20 and the vacuuming device 30 operate alternately in a cycle, a bucket filter 40 is arranged below the discharge port 105, the output end of the bucket filter 40 is connected to the feed end of the visual inspection device 50, the visual inspection device 50 is provided with two material output ends, one of which is connected to the return port 106 through a material pump 1 60, and the other is connected to the feed end of the canning device 80 through a material pump 2 70. When the visual inspection device 50 detects that one of the bubble density, impurities and transparency of the coupling agent is unqualified, the coupling agent is transported back to the inside of the reactor 10 through the material pump 1 60. When the visual inspection device 50 detects that the bubble density, impurities and transparency of the coupling agent are all qualified, the coupling agent is transported to the canning device 80 through the material pump 2 70.

[0020] At the front end of the equipment process, a feeding mechanism can also be added, which includes multiple raw material storage tanks, which are used to store various raw materials of medical sterile coupling agents, such as gel matrix, moisturizer, preservative, etc. The storage tanks are made of stainless steel and have sealing and heat preservation functions, which can effectively prevent the raw materials from deteriorating and volatilizing. Each raw material storage tank is connected to the feeding port 101 of the reactor 10 through multiple raw material delivery pipelines, and a high-precision metering pump is set on the raw material delivery pipeline to accurately control the delivery amount of each raw material according to the preset formula. At the same time, a one-way valve and a flow sensor are set on the raw material delivery pipeline. The one-way valve prevents the backflow of the raw material, and the flow sensor monitors the raw material delivery flow in real time and feeds back to the control system so as to adjust the working state of the metering pump in time.

[0021] When the proportioned raw materials are put into the reactor 10, the stirring mechanism is started to stir the raw materials uniformly to mix and form a coupling agent. At the same time, the pressurizing device 20 and the vacuum device 30 are operated alternately, so that the inside of the reactor 10 is alternately in a high pressure environment and a near vacuum environment. It should be noted that a variety of alternating methods can be used, such as: Pressurize first and then vacuum degassing. First, pressurize and degas. Raise the pressure to a suitable range, such as 2 - 5 atmospheres (200 - 500kPa), and maintain it for 10 - 30 minutes. Use the pressure to compress the tiny bubbles originally existing in the coupling agent, and at the same time, allow the gas dissolved in it to dissolve better under high pressure. Then vacuum degassing is performed to reduce the internal pressure to about 1 - 10kPa. At the same time, turn on the stirring device to fully stir the coupling agent in a vacuum environment for 10 - 30 minutes to allow the bubbles to fully escape in a vacuum environment. When the pressure drops suddenly, that is, when the pressure environment is switched from a pressurized environment to a near-vacuum environment, the gas dissolved in the coupling agent will escape more easily due to the reduction in environmental pressure, just like the rapid escape of carbon dioxide gas after opening the cap of a soda bottle. This combination can more thoroughly remove bubbles in the coupling agent.

[0022] Degassing is done by vacuum degassing first, reducing the pressure to about 1 - 10kPa, stirring for 10 - 30 minutes, and removing most of the large bubbles and some dissolved gases in the coupling agent. Then degassing is done by pressurization, raising the pressure to 2 - 5 atmospheres (200 - 500kPa), and maintaining it for 10 - 30 minutes, so that some tiny bubbles that may still remain in the near-vacuum environment are compressed under high pressure, and the remaining gas is further dissolved, so as to achieve a better degassing effect.

[0023] The cycle combination, by repeatedly alternating pressurization and vacuum degassing, constantly changes the pressure environment of the coupling agent, causing the bubbles to repeatedly undergo a process of compression and expansion. This cycle combination can more effectively remove bubbles of various sizes, especially for those stubborn tiny bubbles. Take two cycles as an example. First, pressurization degassing is performed, raising the pressure to 2 - 5 atmospheres (200 - 500kPa) and maintaining it for 10 - 30 minutes. Then vacuum degassing is performed, reducing the pressure to about 1 - 10kPa and stirring for 10 - 30 minutes. This is the first cycle. Then, pressurization degassing is performed again, and the process is the same as the first pressurization degassing, and then vacuum degassing is performed again, and the process is the same as the first vacuum degassing. At each change of environment, attention should be paid to the consistency of the operation to avoid the coupling agent being exposed to the air for too long and re-inhaling air.

[0024] It should be noted that when the testing equipment tests the viscosity, wire drawing degree and pH value of the coupling agent, if the test result is unqualified, then according to the actual test result, the corresponding components and quantities of raw materials are added through the feeding port 101, and the stirring and other operations are repeated to make the performance indicators of the finally mixed and prepared coupling agent meet the requirements. At the same time, when the visual inspection equipment 50 detects that one of the bubble density, impurities and transparency of the coupling agent is unqualified, the coupling agent is transported back to the reactor 10 through the material pump 60, and stirred or filtered again to make the coupling agent meet the expected standards. When the bubble density, impurities and transparency of the coupling agent detected by the visual inspection equipment 50 are all qualified, the canning step can be carried out.

[0025] The coupling agent is repeatedly stirred by the stirring mechanism, and the internal air pressure of the reactor 10 is controlled in cooperation with the pressurizing device 20 and the vacuuming device 30. The alternating operation of the pressurizing device 20 and the vacuuming device 30 causes the inside of the reactor 10 to alternate between high pressure and near-vacuum environments. Thus, on the one hand, tiny bubbles are compressed under the high pressure environment, while allowing the gas dissolved therein to be better dissolved under high pressure, and on the other hand, the bubbles fully escape under the vacuum environment. At the same time, through the alternating changes of the two, a better degassing effect is achieved, so that there are very few bubbles remaining in the produced coupling agent, thereby improving the quality of the product.

[0026] The reactor 10 adopts a double-layer jacket structure, and a temperature control medium cavity 107 is formed between the two layers, which is connected to the circulating temperature control device, so that the liquid medium circulates between the temperature control medium cavity 107 and the circulating temperature control device.

[0027] The combination of the temperature control medium chamber 107 formed by the double-layer jacket structure and the circulating temperature control device makes it possible to accurately control the reaction temperature by circulating hot water or cold water. At the same time, this temperature control method also avoids the problem of local overheating and improves the stability of temperature control.

[0028] The stirring mechanism includes a stirring motor 901, the outer wall of which is fixedly connected to the center of the upper cover of the reactor 10, the output end of the stirring motor 901 passes through the upper cover of the reactor 10 and is fixedly connected to a stirring shaft 902, and a stirring blade 903 is fixedly connected to the bottom of the stirring shaft 902. The stirring blade 903 is driven to rotate by the stirring motor 901, and the coupling agent near the stirring blade 903 is pushed to move toward the bottom of the reactor 10. The bottom wall of the upper cover of the reactor 10 is fixedly connected to a guide tube 905 through a support 904. The middle part of the guide tube 905 is a cylindrical structure, and the upper and lower parts are extended in a trumpet shape respectively. The stirring blade 903 is located in the lower part of the guide tube 905, and the upper opening of the guide tube 905 is close to the coupling agent liquid surface and is located below the liquid surface.

[0029] The stirring shaft 902 is driven to rotate by the stirring motor 901, thereby driving the stirring blade 903 to rotate at a high speed. On the one hand, the rotation of the stirring blade can generate a strong shear force and convection effect, so that the raw materials are fully mixed and uniform in a short time. On the other hand, in cooperation with the guide tube 905, when the stirring blade 903 pushes the coupling agent to move toward the bottom of the reactor 10, this part of the coupling agent is squeezed into the bottom of the reactor 10, and the coupling agent originally at the bottom is moved upward. At the same time, the vacancy of the coupling agent in the guide tube 905 is filled by the upper opening of the guide tube 905 close to the liquid surface, thereby forming a bottom-up convection of the coupling agent. In this process, not only the mixing and stirring effect is improved, but also the bubbles in the bottom coupling agent are moved to the upper layer. When the bubbles move to the upper layer of the coupling agent, the liquid pressure on them is further reduced due to the change in the depth position, thereby increasing the probability of the bubbles detaching from the coupling agent.

[0030] At the same time, by utilizing the special structural design of the guide tube 905, when the coupling agent enters from the upper bell mouth, the cross-sectional area of ​​the flow channel gradually decreases, and the coupling agent is accelerated in the convergent section of the bell mouth. According to the continuity equation, the flow channel cross-sectional area decreases, and the flow velocity must increase. After the coupling agent is accelerated, it enters the middle cylindrical part. At this time, due to the regular shape of the flow channel, the coupling agent can maintain a relatively stable high-speed flow state. This stable high-speed flow can make the components in the coupling agent initially evenly distributed in the axial direction. Then the coupling agent enters the diffusion section of the lower bell mouth, the cross-sectional area of ​​the flow channel gradually increases, the flow velocity slows down, and the coupling agent pressure rises. In this process, the change of the coupling agent from acceleration to stability and then to deceleration will produce a complex pressure gradient, which is conducive to the mixing of different components. Just like in a river, when the water flows through a river channel with varying widths, vortices and turbulence of the water flow will be generated, which promotes better mixing of impurities and other components in the water. In the convergent section of the bell mouth, in addition to acceleration, the coupling agent will also be squeezed toward the center. If there are components of different densities or viscosities in the coupling agent, this squeezing will cause them to gather toward the center and begin preliminary mixing. When entering the cylindrical part, due to the stable flow rate, the relative positions between the components are further adjusted, and the mixing is more uniform. In the diffusion section of the bell mouth, due to the slow flow rate and pressure recovery, a reverse pressure gradient will be generated. This will cause the coupling agent to produce backflow and vortexes, further enhancing the mixing effect. For the production of medical sterile coupling agents, different additives and matrix components, this flow channel design can make the additives better dispersed in the matrix, improve the uniformity and quality of the coupling agent. At the same time, this design can adapt to the mixing of coupling agents with different viscosities. For coupling agent raw materials with higher viscosity, the acceleration and extrusion effect of the bell mouth can help overcome the viscous resistance and make the components mix smoothly; for liquids with lower viscosity, the complex flow patterns in the cylindrical part and the diffusion section can also achieve efficient mixing. At the same time, this flow channel structure can also reduce energy loss during mixing and improve production efficiency.

[0031] Of course, there are other ways to implement the special structure of the guide tube 905, such as: An internal thread is provided on the inner wall of the guide tube 905. The internal thread adopts a triangular thread with a thread angle of 55°, and the surface roughness of the internal thread is Ra0.8-Ra1.6μm. The thread on the inner wall of the pipe can cause bubbles to burst, thereby playing a certain role in eliminating bubbles. When bubbles move along the inner wall of the pipe and contact the thread, due to the irregularity of the thread surface, local pressure changes will occur on the bubbles. For example, when the bubble collides with the sharp edge of the thread, the pressure on the bubble in this local area will suddenly increase. According to Laplace's law, the bubble radius will decrease when the pressure increases. If the pressure is large enough, the bubble will break into multiple smaller bubbles. These small bubbles may further break or dissolve in the coupling agent during the subsequent flow process, thereby reducing the total volume of the bubble to a certain extent. At the same time, the thread on the inner wall of the pipe changes the flow state of the coupling agent, which helps to dissolve the bubbles. As mentioned above, the thread causes turbulence and vortexes in the liquid. This complex flow state increases the contact area and contact time between the liquid and the bubble. For gas dissolved in liquid, according to Henry's law, when the flow state of the liquid around the bubble changes, the balance relationship between the partial pressure and concentration of the gas in the liquid will be dynamically adjusted. Under the action of turbulence and eddies, the liquid around the bubble is constantly renewed, making it easier for the gas in the bubble to dissolve into the liquid, thereby reducing the presence of bubbles. At the same time, it also further improves the mixing efficiency.

[0032] The guide tube 905 can also be set as a cylindrical structure as a whole, and a vortex generator is set in the middle of the guide tube 905. Through the action of the vortex generator, when the coupling agent flows through the vortex generator, vortices with opposite rotation directions are alternately generated on both sides thereof, and are regularly arranged in the wake behind the vortex generator, thereby reducing the presence of bubbles through complex vortices and further improving the mixing efficiency.

[0033] A filter screen 906 is fixedly installed at the lower opening of the guide tube 905 , and its filter mesh number is greater than the filter mesh number of the bucket filter 40 .

[0034] A filter 906 is additionally provided at the lower opening of the guide tube 905. The filter 906 adopts a structure with a large mesh opening, and can filter large particles of impurities in the coupling agent while minimizing the impact on the flow velocity. At the same time, when the bubbles in the coupling agent pass through the filter 906, they are cut by the filter 906 to form smaller bubbles. Then, during repeated stirring, the bubbles in the coupling agent that are difficult to discharge gradually decrease in size, and are dissolved into the coupling agent under the cooperation of the high-pressure environment, so that the bubbles are further eliminated.

[0035] A sterilizing device is also provided between the canning device 80 and the visual inspection device 50 for sterilizing the coupling agent.

[0036] There are many sterilization methods, which can be selected according to the actual properties of the coupling agent, such as: The moist heat sterilizer uses high temperature and high pressure steam to sterilize the filtered coupling agent. The sterilization temperature can be adjusted between 100 - 135°C, the pressure is between 0.1 - 0.3MPa, and the sterilization time can be set within 10 - 60 minutes according to the amount and properties of the coupling agent to ensure complete killing of microorganisms.

[0037] Radiation sterilization devices, as a supplement or alternative to moist heat sterilization, use radiation sources such as ultraviolet rays and gamma rays to sterilize coupling agents. They have the advantages of fast sterilization speed and no residue, and are suitable for heat-sensitive coupling agent formulations.

[0038] After the coupling agent is sterilized, it enters the canning device 80 for automatic filling. The canning device 80 can accurately fill the coupling agent according to the preset filling volume, and the filling volume error is controlled within ±0.5%. It can adapt to packaging containers of different specifications, such as syringes, hoses, bottles, etc.; and the filled containers are sealed to ensure the sealing and shelf life of the product.

[0039] Finally, the filled products are automatically labeled with information such as product name, specifications, production date, expiration date, and instructions for use. Packaging operations such as boxing and cartoning are then carried out to improve production efficiency and consistency of packaging quality.

[0040] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An automatic production device for a medical sterile coupling agent, comprising a reaction kettle (10), characterized in that: The reactor (10) is provided with a stirring mechanism. A feeding port (101), a detection port (102), an air inlet (103), an exhaust port (104), a discharge port (105) and a return port (106) are sequentially provided on the reactor body of the reactor (10). The feeding port (101), the detection port (102), the air inlet (103), the exhaust port (104), the discharge port (105) and the return port (106) are respectively provided with electromagnetic valves in a one-to-one correspondence. The feeding port (101) is used to add coupling agent raw materials. The detection port (102) is used to insert a detection device and detect the viscosity, wire drawing degree and pH value of the coupling agent. The air inlet (103) is connected to the air outlet of the pressurizing device (20). The exhaust port (104) is connected to the exhaust port of the vacuuming device (30). The pressurizing device (20) and the vacuuming device (30) are used to control the The internal air pressure of the reaction kettle (10) is reduced, a bucket filter (40) is arranged below the discharge port (105), the output end of the bucket filter (40) is connected to the feed end of the visual inspection device (50), the visual inspection device (50) is provided with two material output ends, one of which is connected to the return port (106) through a material pump 1 (60), and the other is connected to the feed end of the canning device (80) through a material pump 2 (70). When the visual inspection device (50) detects that any one or more of the bubble density, impurities and transparency of the coupling agent are unqualified, the coupling agent is transported back to the interior of the reaction kettle (10) through the material pump 1 (60); when the visual inspection device (50) detects that the bubble density, impurities and transparency of the coupling agent are all qualified, the coupling agent is transported to the canning device (80) through the material pump 2 (70).

2. The automatic production equipment of medical sterile coupling agent according to claim 1, characterized in that: The reaction kettle (10) adopts a double-layer jacket structure, a temperature control medium cavity (107) is formed between the two layers, and the temperature control medium cavity (107) is connected to a circulating temperature control device, so that a liquid medium circulates between the temperature control medium cavity (107) and the circulating temperature control device.

3. The automatic production equipment of a medical sterile coupling agent according to claim 1, characterized in that: The stirring mechanism comprises a stirring motor (901), the stirring motor (901) being fixedly connected to the center of the upper cover of the reactor (10), the output end of the stirring motor (901) passing through the upper cover of the reactor (10) and being fixedly connected to a stirring shaft (902), the bottom of the stirring shaft (902) being fixedly connected to a stirring blade (903), the stirring motor (901) being used to drive the stirring blade (903) to rotate and to push the coupling agent near the stirring blade (903) to move toward the bottom of the reactor (10).

4. The automatic production equipment of medical sterile coupling agent according to claim 3, characterized in that: The bottom wall of the upper cover of the reaction kettle (10) is fixedly connected to a guide tube (905) via a support (904); the stirring blade (903) is located at a lower part inside the guide tube (905); and the upper opening of the guide tube (905) is close to the coupling agent liquid surface and is located below the liquid surface.

5. The automatic production equipment of medical sterile coupling agent according to claim 4, characterized in that: The inner wall of the guide tube (905) is provided with an internal thread, the internal thread adopts a triangular thread with a thread angle of 55°, and the surface roughness of the internal thread is Ra0.8-Ra1.6μm.

6. The automatic production equipment of medical sterile coupling agent according to claim 4, characterized in that: The guide tube (905) has a cylindrical structure in the middle, and the upper and lower parts extend outwards in a trumpet shape.

7. The automatic production equipment of medical sterile coupling agent according to claim 4, characterized in that: The guide tube (905) is a cylindrical structure as a whole, and a vortex generator is arranged in the middle of the guide tube (905).

8. The automatic production equipment of medical sterile coupling agent according to claim 4, characterized in that: A filter screen (906) is fixedly installed at the lower opening of the guide tube (905), and its filter mesh number is greater than the filter mesh number of the bucket filter (40).

9. The automatic production equipment of medical sterile coupling agent according to claim 1, characterized in that: During the operation of the stirring mechanism, the pressurizing device (20) and the vacuuming device (30) operate alternately in a cycle.

10. The automatic production equipment of medical sterile coupling agent according to claim 1, characterized in that: A sterilizing device is also provided between the canning device (80) and the visual inspection device (50), and the sterilizing device is used to sterilize the coupling agent.

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