Detection device and test paper

Abstract

The detection device and the detection test paper include a detection board and the detection test paper, the detection board includes an upper cover and a bottom plate, the detection test paper is installed between the upper cover and the bottom plate, a positioning column is arranged in the detection board, and a positioning hole is opened on the detection test paper, the longitudinal dimension of the positioning hole is substantially the same as the longitudinal dimension of the positioning column, and the transverse dimension of the positioning hole is larger than the transverse dimension of the positioning column. The detection device and the detection test paper can improve the success rate of the detection test paper being installed on the detection board and reduce the scrap rate of the detection test paper production.

Description

[0001] This application is filed on November 10, 2020, with application number 2020112475276 and invention name

[0002] Divisional application of the patent application for "Detection device and test strip with test strip positioning structure". Technical Field

[0003] The invention relates to the field of detection using a detection test paper, and in particular to a positioning device for the detection test paper in a detection box. Background Art

[0004] Currently, more and more products that can achieve on-site sampling and obtain test results immediately are being studied and applied in clinical practice. This type of testing is usually called point-of-care testing (POCT).

[0005] This type of instant test is often completed using a dry test strip with a reagent. For example, a lateral flow test strip generally includes a support pad, on which a sample pad, a marking pad, a detection pad and an absorbent pad are arranged one after another from upstream to downstream. The liquid sample dripped on the sample pad flows through the sample pad, the marking pad, the detection pad and the absorbent pad in sequence. After the detection is completed, the color depth of the color developed by the detection pad is linearly related to the concentration of the analyte in the sample to be detected, thereby judging the level of the corresponding analyte in the sample. For example, a vertical flow test strip generally includes a support pad, on which a sample pad, a separation pad and a detection pad are arranged in sequence from top to bottom, and the support pad is provided with an observation hole at the detection pad. The test strip also includes a variety of test strips such as urine joint test strips with a variety of detection pads arranged at intervals on the support pad. The test strips can use various detection methods suitable for instant testing requirements, such as electrochemical methods and photochemical methods, to measure hormone levels, drugs, allergens, physiological indicators in urine, HBV, HCV, HIV, malaria, dengue fever, influenza, Middle East respiratory syndrome, SARS and 2019-nCoV, blood sugar, uric acid, blood ketones, cholesterol, lactic acid, etc.

[0006] like Figure 8 and 9As shown, the sample adding pad, marking pad, test pad containing test line (T line) and control line (C line), water absorbent pad, etc. of the test paper are usually pre-made on a large card 200, and a positioning hole 30 is punched out at the position of the large card water absorbent pad, and then a roller or other cutter cuts the large card into a single test paper in the longitudinal direction of the large card. The test paper can be used directly for detection, or the test paper can be placed in a detection device. The detection board generally includes an upper cover and a bottom plate, and the test paper is installed between the upper cover and the bottom plate, and the upper cover or the bottom plate is provided with a sample adding hole and a test result reading window. In order to prevent the test paper installed in the detection board from moving longitudinally and deviating from the installation position, a positioning column 31 is usually set up on the inner wall of the detection board, and a positioning hole 30 is opened at the corresponding position of the test paper. When the test paper is assembled into the detection board, the test paper is sleeved on the positioning column through the positioning hole to prevent the movement of the test paper in the detection board as much as possible.

[0007] The shape of the positioning hole in existing products is consistent with the positioning post. For example, if the positioning post is round, the positioning hole is also round, and the positioning post can be inserted into the positioning hole to achieve a tight fit or interference fit between the positioning post and the positioning hole in both the longitudinal and transverse directions. Under such a design, the position of the positioning hole of the test strip must be consistent with the position of the positioning post. For example, if the center point of the positioning post is on the longitudinal center axis of the detection device, the center point of the positioning hole must also be on the longitudinal center axis of the test strip. Fig. 9 The vertical solid line of the large card 200 shown in A represents the accurate cutting position. Cut according to the solid line position to obtain the following Fig. 9 The center point of the positioning hole 30 of the single test paper 2 shown in B is exactly located on the longitudinal axis of the test paper. When the hob cuts accurately at the solid line position, Fig. 9 The circular positioning post 31 shown in C can be inserted into the circular positioning hole 31 of the test strip.

[0008] If the position of the positioning hole deviates, such as the positioning hole is offset due to crooked cutting by a roller or cutter, the positioning post of the detection board will not be able to be inserted into the positioning hole of the test paper, and the test paper cannot be installed in the detection board.

[0009] like Fig.10 The vertical solid line of the large card 200 shown in A represents the accurate cutting position, and the vertical dotted line represents the actual cutting position of the hob. In this example, the cutting position (dotted line) is rightward of the preset position (solid line). The hob cuts at the dotted line position to obtain the following Fig.10 The positioning hole 30 of the single test strip 2 shown in B deviates to the left from the longitudinal axis. Fig.10 As shown in FIG. C, the circular positioning post 31 cannot be inserted into the circular positioning hole 30 of the test strip.

[0010] like Fig.11The vertical solid line of the large card 200 shown in A represents the accurate cutting position, and the vertical dotted line represents the actual cutting position of the roller. In this example, the cutting position (dotted line) is leftward of the preset position (solid line). The roller cuts at the dotted line position to obtain the following Fig.11 The positioning hole 30 of the single test strip 2 shown in B deviates to the right from the longitudinal axis. Fig.11 As shown in FIG. C, the circular positioning post 31 cannot be inserted into the circular positioning hole 30 of the test strip.

[0011] Therefore, in the manufacturing process, the existing processing technology of test strips will lead to a high scrap rate of test strips. Fig.10 B and Fig.11 The test strip shown in B will not be usable. Therefore, each time a test strip is made, the positioning hole must be strictly controlled at the position when the product is designed. If the hob, cutter, etc. are used for cutting, the positioning hole may be cut crookedly, causing it to slightly deviate from the pre-designed position. When the positioning post is inserted into the positioning hole of this type of test strip, the test strip cannot be installed in the correct position of the detection device because the positioning hole deviates from the pre-set position, and the detection cannot be carried out. Therefore, the current production process of test strips with positioning holes requires high precision. Summary of the invention

[0012] In order to improve the success rate of installing the test paper on the test board and reduce the accuracy of the production process of the test paper, especially the cutting accuracy of the test paper, one of the purposes of the present invention is to provide a detection device, including: a test board and a test paper, the test board includes an upper cover and a bottom plate, the test paper is installed between the upper cover and the bottom plate, a positioning column is arranged in the test board, a positioning hole is opened on the test paper, the positioning column is inserted into the positioning hole, the longitudinal dimension of the positioning hole is basically the same as the longitudinal dimension of the positioning column, and the dimensions in other directions are equal to or greater than the dimensions of the positioning column.

[0013] The present invention provides a detection device, including a detection board and a detection test paper, the detection board includes an upper cover and a bottom plate, the detection test paper is arranged between the upper cover and the bottom plate, a positioning hole is opened on the detection test paper, and a positioning column inserted into the positioning hole is provided on the detection board. When the positioning column is inserted into the positioning hole, the positioning column can basically not move in the longitudinal direction of the positioning hole, and the positioning column can move in the transverse direction of the positioning hole.

[0014] In the present invention, the length direction of the test paper is the longitudinal direction, that is, the flow direction of the liquid on the test paper is the longitudinal direction; the direction perpendicular to the flow direction of the liquid is the transverse direction; wherein the test paper is cut along the longitudinal direction. When the dimensions in the remaining directions are greater than or equal to the positioning column, the test paper is installed on the detection board, and the positioning column is easier to insert into the positioning hole, so as to avoid the positioning hole deviating from the pre-set position and failing to be installed in the correct position of the detection device.

[0015] Taking the lateral flow test strip as an example, the longitudinal direction of the present invention is the direction of liquid flow from the sample pad to the detection pad on the test strip, and the direction perpendicular to the liquid flow direction is the transverse direction. Fig. 9 and Fig.10 As shown, when a single test paper is cut with a cutter, the direction parallel to the cutter's edge is the longitudinal direction, and the direction perpendicular to the cutter's edge is the transverse direction. Taking the vertical flow test paper as an example, the added sample will diffuse around the test pad. When the test paper is cut with a cutter into a single test paper, the direction parallel to the cutter's edge is the longitudinal direction, and the direction perpendicular to the cutter's edge is the transverse direction.

[0016] After the positioning column is inserted into the positioning hole, the longitudinal direction of the positioning column is the same as the longitudinal direction of the positioning hole, and the transverse direction of the positioning column is the same as the transverse direction of the positioning hole.

[0017] Furthermore, in the longitudinal direction, the positioning hole and the positioning column are tightly fitted; in the remaining directions, the positioning hole and the positioning column are loosely fitted.

[0018] Furthermore, the positioning hole and the positioning column are tightly matched in the longitudinal direction, and are loosely matched in the transverse direction.

[0019] Furthermore, the lateral dimension of the positioning hole is larger than the lateral dimension of the positioning post.

[0020] Furthermore, the positioning hole is elliptical, strip-shaped or rectangular.

[0021] Furthermore, the long axis direction of the ellipse is the lateral direction of the positioning hole, the short axis direction of the ellipse is the longitudinal direction of the positioning hole, the long side direction of the rectangle is the lateral direction of the positioning hole, and the short side direction of the rectangle is the lateral direction of the positioning hole.

[0022] The lateral flow test paper comprises a support pad, on which a sample pad, a marking pad, a detection pad and a water absorption pad are arranged in sequence from upstream to downstream and overlapped with each other. The positioning hole is located on the water absorption pad.

[0023] The test paper comprises a support pad, a detection pad on the support pad or detection pads are arranged at intervals on the support pad, and a positioning hole is located on the support pad.

[0024] Further, the detection board also includes transverse limiting posts. In a preferred embodiment, the distance between the transverse limiting posts on the opposite sides is such that the detection paper placed therebetween is tightly fitted with the transverse limiting posts.

[0025] The present invention also provides a test strip, comprising a support pad, a test pad and a positioning hole, wherein the longitudinal dimension of the positioning hole is substantially the same as the longitudinal dimension of a positioning post matched therewith, and the transverse dimension of the positioning hole is larger than the transverse dimension of the positioning post.

[0026] The invention provides a detection test paper, comprising a detection pad and a positioning hole, wherein the longitudinal dimension of the positioning hole is substantially the same as the longitudinal dimension of a positioning column matched therewith, and the transverse dimension of the positioning hole is larger than the transverse dimension of the positioning column matched therewith.

[0027] The lateral dimension of the positioning hole on the test paper is larger than the positioning column of the test board, so that the positioning hole and the positioning column form a loose fit in the lateral direction, which can effectively reduce the probability that the cut test paper cannot be loaded into the test board due to the deviation caused by cutting the large card to make the test paper, and reduce the scrap rate of the material. At the same time, the test paper can be kept in a fixed position on the test board. In the assembly of the test paper, it can also avoid the test paper being twisted in the test board due to the deflection of the test paper, which affects the test results. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 It is a schematic diagram of an exploded view of a detection device containing a detection test strip according to the present invention.

[0029] Figure 2 It is a test paper with a circular positioning hole. Test paper A indicates that the circular positioning hole is located on the central axis of the test paper, test paper B indicates that the circular positioning hole deviates from the central axis, and test paper C indicates that the circular positioning hole deviates from the central axis.

[0030] Figure 3 It is a test paper with an elliptical positioning hole. Test paper A indicates that the elliptical positioning hole is located on the central axis of the test paper, test paper B indicates that the elliptical positioning hole deviates from the central axis, and test paper C indicates that the elliptical positioning hole deviates from the central axis.

[0031] Figure 4 It is the positional relationship between the elliptical positioning hole and the circular positioning column. A means the positioning column is in the middle of the positioning hole, and B means the positioning column is offset to the right or left side of the positioning hole.

[0032] Figure 5 It is the positional relationship between the rectangular positioning hole and the circular positioning column. A means the positioning column is in the middle of the positioning hole, and B means the positioning column is offset to the right or left side of the positioning hole.

[0033] Figure 6 It is the positional relationship between the elliptical positioning hole or rectangular positioning hole and the cross-shaped positioning column. A and C indicate that the positioning column is in the middle of the positioning hole, and B and D indicate that the positioning column is offset to the right or left side of the positioning hole.

[0034] Figure 7It is a schematic diagram of the test strip of the present invention installed on the bottom plate. A indicates that the positioning hole of the test strip is exactly located on the central axis of the test strip, and the positioning post inserted into the positioning hole is located in the middle of the positioning hole. B indicates that the positioning hole of the test strip is opened offset and located below the central axis of the test strip. The positioning post can still be accurately inserted into the positioning hole, and the positioning post is located on one side of the positioning hole.

[0035] Figure 8 Uncut large card.

[0036] Fig. 9 Examples of the roller cutting at the correct position of the large card. 9A shows the large card that has not been cut, and the solid line in the longitudinal direction of the large card shows the correct cutting position; 9B shows a single test paper after cutting; 9C shows the situation where the positioning hole is inserted into the positioning hole of the test paper in 9B.

[0037] Fig.10 An example of a roller cutter cutting position deviating to the right from the accurate cutting position, 10A represents a large card that has not been cut, the solid line in the longitudinal direction of the large card represents the correct cutting position, and the dotted line represents the actual cutting position; 10B represents a single test paper after cutting; 10C represents the situation where the positioning post cannot be inserted into the positioning hole of the test paper 10B.

[0038] Fig.11 An example of a roller cutter cutting position deviating to the left from the accurate cutting position, 11A represents a large card that has not been cut, the solid line in the longitudinal direction of the large card represents the correct cutting position, and the dotted line represents the actual cutting position; 11B represents a single test paper after cutting; 11C represents the situation where the positioning post cannot be inserted into the positioning hole of the test paper 11B. DETAILED DESCRIPTION

[0039] The present invention is described in detail below in conjunction with specific drawings. These specific embodiments are only limited enumerations without violating the spirit of the present invention, and do not exclude other specific implementation schemes produced by ordinary technicians in the field by combining the prior art with the present invention.

[0040] like Figure 1The detection device 1 shown includes a detection board and a detection test paper, and the detection board includes an upper cover 11 and a bottom plate 12, and the upper cover and the bottom plate are assembled together to form the shell of the detection board. The detection test paper 2 is installed between the upper cover and the bottom plate, and the detection test paper is placed in a relatively fixed position in the detection board to ensure that the detection result can be accurately obtained. A circular positioning column 31 is designed at one end of the bottom plate, and the circular positioning column is set on the longitudinal center axis of the detection device. A positioning hole 30 is opened on the detection test paper at the corresponding position of the positioning column, and the positioning column 31 is inserted into the positioning hole 30 to reduce or eliminate the movement of the detection test paper in the longitudinal direction of the detection board. Transverse limiting columns 32 are also designed on both sides of the bottom plate relative to the longitudinal direction of the detection test paper, and the distance between the transverse limiting columns 321 and 322 on the opposite sides makes the detection test paper placed therein and the transverse limiting columns be clamped and matched to reduce or eliminate the movement of the detection test paper in the transverse direction of the detection board. The positioning column and the transverse limiting column can be arranged on the bottom plate as a separate component, or they can be combined with other components and arranged on the bottom plate. The positioning column and the limiting column can also be arranged on the upper plate.

[0041] Rivets 13 are arranged around the inner side of the upper cover, and a lock hole 14 is arranged at a position of the bottom plate relative to the rivets of the upper cover. The rivets 13 on the upper cover and the lock holes 14 on the bottom plate are interference fit to tightly assemble the upper cover and the bottom plate together. Of course, the positions of the rivets and the lock holes on the upper cover and the bottom plate can be interchanged. In a preferred design, the lock hole 14 is arranged in the transverse limit column 32. Rivets and lock holes may not be arranged between the upper cover and the bottom plate, but they may be assembled together by other means such as ultrasonic welding.

[0042] The longitudinal dimension of the test paper positioning hole 30 is tightly matched with the longitudinal dimension of the detection board positioning column 31, such as mutually clamped or interference fit, and the positioning column inserted in the positioning hole can basically not move in the longitudinal direction of the positioning hole, thereby limiting the movement of the test paper in the longitudinal direction of the detection board. The transverse dimension of the test paper positioning hole 30 is larger than the transverse dimension of the detection board positioning column 31, and the positioning column can move in the transverse direction of the positioning hole. The transverse limit column of the detection board is used to limit the movement of the test paper in the transverse direction of the detection board.

[0043] In the process of cutting a single test strip or punching out the positioning holes, the positions of the positioning holes on different single test strips may be different. For example, the positioning holes are located exactly on the longitudinal center axis of the test strip. Figure 2 Middle A, Figure 3 As shown in A; the positioning hole is located above the longitudinal center axis, as shown in Figure 2 Middle B, Figure 3 As shown in B; the positioning hole is located below the longitudinal center axis, as shown in Figure 2 Middle C, Figure 3 As shown in C. Figure 2 A to Figure 2The positioning hole in the middle C is the existing technology, and the positioning hole matched with the circular positioning column is circular. The longitudinal and transverse dimensions of the positioning hole 30 of the test paper are both tightly matched with the longitudinal and transverse dimensions of the circular positioning column 31 of the detection device. Figure 3 A to Figure 3 The positioning hole in C is the technology described in the present invention. The positioning hole matched with the circular positioning column 31 is an ellipse, which is composed of two relatively parallel sides and arc-shaped sides at both ends. The longitudinal dimension of the positioning hole 30 of the test paper is a clamping fit with the longitudinal dimension of the positioning column 31 of the detection device, and the transverse dimension of the positioning hole 30 is larger than the transverse dimension of the positioning column 31 of the detection device.

[0044] When the locating column is located on the longitudinal center axis of the detection device and is fixed, Figure 2 Middle A and Figure 3 After the test papers A, B, and C are placed between the horizontal limit posts, the circular positioning posts can still be inserted into the positioning holes. Figure 2 After the test paper described in B and C is placed between the lateral limit posts, the circular positioning post cannot be inserted into the positioning hole where the deviation occurs.

[0045] like Figure 4 As shown, the positioning post is circular, the positioning hole is elliptical, the longitudinal dimension of the positioning hole is substantially the same as the outer diameter of the circular positioning post, the transverse dimension of the positioning hole is larger than the outer diameter of the circular positioning post, and the positioning post can be located at the center of the positioning hole, see Figure 4 A in the middle can also be located anywhere between the two ends, see Figure 4 Middle B.

[0046] Figure 5 As shown, the positioning post is circular, the positioning hole is rectangular, the longitudinal dimension of the positioning hole is substantially the same as the outer diameter of the circular positioning post, the transverse dimension of the positioning hole is larger than the outer diameter of the circular positioning post, and the positioning post can be located at the center of the positioning hole, see Figure 5 A in the middle can also be located anywhere between the two ends, see Figure 5 Middle B.

[0047] Figure 6 As shown, the positioning column is cross-shaped, the positioning hole is oval or rectangular, the longitudinal dimension of the positioning hole is substantially the same as the outer diameter of the cross-shaped positioning column, and the transverse dimension of the positioning hole is larger than the outer diameter of the cross-shaped positioning column. The positioning column can be located at the center of the positioning hole, see Figure 6 A and C can also be located anywhere between the two ends. Figure 6 In B, D. Figure 7As shown in Figure A, the cross-shaped positioning column is located on the longitudinal center axis of the test board, and the center point of the elliptical positioning hole made into a single test paper is exactly located on the longitudinal center axis of the test paper. When the test paper is placed between the horizontal limit columns, the cross-shaped positioning column can be inserted into the positioning hole. Figure 7 As shown in B, the position of the positioning hole made into a single test paper is deviated, and the center point of the positioning hole is not located on the longitudinal center axis of the test paper. When the test paper is placed between the lateral limit posts, the cross-shaped positioning post can still be smoothly inserted into the positioning hole and is located on one side of the positioning hole. When the test paper is installed in place, the sample pad and the detection pad are both in the accurate position of the detection device, ensuring the smooth progress of the detection and the detection results can be smoothly obtained from the detection window 15 of the detection device. Even if the positioning hole is deviated in position during the processing, the technology of the present invention can still allow the test paper to be installed in the correct position in the detection device, and the positioning hole described in the present invention cooperates with the positioning post to reduce or limit the longitudinal movement of the test paper in the detection device, and the lateral limit posts cooperate with both sides of the test paper to limit the lateral movement of the test paper in the detection device.

[0048] The test strips can be Figure 1 The lateral flow test paper 2 shown includes a support pad 21, a sample adding pad 22, a marking pad 23, a detection pad 24 and a water absorbing pad 25. The marking pad is provided with a test line T line and a control line C line, and a positioning hole is provided on the water absorbing pad. The test paper can also be a test paper with multiple detection pads arranged at intervals on the support pad, such as a urine combined detection test paper and other forms of test paper, and the positioning hole can also be provided on the support pad.

[0049] Those skilled in the art can design different shapes of positioning posts and positioning holes as needed, and reserve a certain offset for the positioning posts in the longitudinal direction. The final size of the positioning holes in the transverse direction takes into account the width and strength of the test paper. On the basis of meeting the structural strength, the size of the positioning holes can also be enlarged as much as possible. The positioning holes are set at appropriate positions corresponding to the test paper according to the different positions of the positioning posts.

[0050] The loose longitudinal fit between the positioning hole and the positioning post described in the present invention reduces the probability that the positioning hole will deviate and the test paper cannot be loaded into the test board due to the cutting deviation caused by cutting a large card to produce a single test paper. It can also reduce the probability that the positioning hole cannot be assembled with the positioning post and the test paper cannot be loaded into the test board due to deviation when punching and drilling the positioning hole. The design of the present invention can greatly reduce the scrap rate of materials in the process of manufacturing test papers. During installation, it also reduces the distortion of the test paper in the detection device caused by the deviation of the test paper, thereby affecting the test results.

Claims

1. A detection device, comprising: A detection board and a detection test paper, the detection board includes an upper cover and a bottom plate, the detection test paper is installed between the upper cover and the bottom plate, a positioning column is arranged in the detection board, and a positioning hole is opened on the detection test paper, which is characterized in that: the longitudinal dimension of the positioning hole is substantially the same as the longitudinal dimension of the positioning column, and the transverse dimension of the positioning hole is larger than the transverse dimension of the positioning column.

2. The detection device according to claim 1, characterized in that: In the longitudinal direction, the positioning hole and the positioning column are tightly matched, and in the transverse direction, the positioning hole and the positioning column are loosely matched.

3. The detection device according to claim 1, characterized in that: The shape of the positioning hole is oval or rectangular.

4. The detection device according to claim 1, characterized in that: The test paper includes a support pad, a sample adding pad, a marking pad, a test pad and a water absorbing pad.

5. The detection device according to claim 4, characterized in that: The positioning holes are located on the absorbent pad.

6. The detection device according to claim 1, characterized in that: The test paper comprises a support pad, a detection pad on the support pad, or detection pads arranged at intervals on the support pad.

7. The detection device according to claim 6, characterized in that: The locating holes are located on the support pads.

8. The detection device according to any one of claims 1 to 7, characterized in that: The detection plate also includes transverse limiting columns.

9. The detection device according to claim 8, characterized in that: The distance between the lateral limiting posts on the opposite sides is such that the test paper placed therebetween is tightly fitted with the lateral limiting posts.

10. A test strip comprising a support pad, a test pad and a positioning hole, characterized in that: The longitudinal dimension of the positioning hole is substantially the same as the longitudinal dimension of the positioning column matched therewith, and the transverse dimension of the positioning hole is larger than the transverse dimension of the positioning column.

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