Sterilizing and bactericidal compositions with residence time indicators and cleaning articles containing same

Abstract

The present invention relates to a liquid disinfecting and / or bactericidal composition comprising an active agent, an indicator compound, an acid and a solvent. The composition can be applied to a surface by spraying or transferring from a cleaning article to eliminate pathogens on the surface. The indicator compound may include a dye, such as a cyanine dye, that provides a color to the composition and has at least one maximum absorption value in the visible light region. Once applied to the surface, the composition changes color and becomes colorless.

Description

Background Art

[0001] Disinfection and sterilization liquid are used to clean various surfaces in various environments (comprising hospitals, medical offices, families, commercial buildings, restaurants and other public facilities). Disinfection and sterilization liquid compositions usually contain one or more activating agents with antibacterial, antiviral, antifungal and / or antiparasitic activity. These liquid compositions can be applied on the surface by spraying or can be transferred to the surface from cleaning products (for example, substrate, such as wipes, cloth, sponges, etc.). However, since disinfection and sterilization liquid are usually provided in the form of transparent colorless solution, the user cannot easily determine whether the whole surface has been contacted with disinfection and / or sterilization composition by visual inspection. Simply adding conventional colorants to the liquid is not an acceptable solution, because the user cannot tolerate the permanent coloring of the clean surface.

[0002] The user also cannot determine whether the concentration of the disinfecting and / or sanitizing composition and the duration of contact with the surface are sufficient to ensure that the active agent has eliminated any target pathogens. In addition, if too much liquid is lost due to evaporation, the cleaning product will lose effectiveness over time. If there is not enough liquid, the composition cannot be effectively transferred from the substrate to the target surface. It is often difficult for the user to determine how much liquid has been lost from the product, and therefore it is often difficult to determine whether a particular cleaning product is still effective in eliminating target pathogens.

[0003] Therefore, there is a need for disinfecting and sterilizing compositions that can reliably indicate whether a surface has been contacted with a disinfecting and sterilizing liquid composition. There is also a need for disinfecting and sterilizing liquid compositions that can reliably indicate the length of time the composition has been in contact with a surface. There is also a need for improved cleaning products that can reliably indicate whether the liquid retained in the cleaning product is sufficient to ensure proper transfer of the disinfecting and sterilizing composition to a surface.

[0004] In accordance with the purposes of the disclosed materials and methods, as embodied and broadly described herein, in one aspect, the disclosed subject matter relates to compounds, compositions, and methods of making and using the compounds and compositions.

[0005] Additional advantages will be explained in part in the subsequent description and in part understood from the description, or can be learned by practicing the aspects described below. The advantages described below will be realized and obtained by means of the elements and combinations specifically pointed out in the appended claims. It should be understood that the above general description and the following detailed description are merely exemplary and illustrative, and not restrictive.

[0006] The details of one or more embodiments are set forth in the description below. Other features, objects, and advantages will be apparent from the description and claims. Summary of the invention

[0007] Disclosed herein is a liquid composition comprising a residence time indicator system. The composition can be used to disinfect and / or sterilize a variety of surfaces. The indicator system comprises one or more cyanine dyes and one or more organic acids. The composition is in a colored state (i.e., has a certain absorption in the visible spectrum) when wetted, and is converted to a substantially colorless state when applied to a surface and most of the composition is evaporated. For example, in some embodiments, when the composition is applied to a surface and 95% of the composition is evaporated, the composition is converted to a substantially colorless state.

[0008] The liquid disinfecting and / or sterilizing composition also comprises one or more active ingredients, for example, antimicrobial, antiviral, antifungal active ingredients, or active ingredients with a combination of these capabilities. The composition also comprises a solvent or a solvent mixture. The composition optionally comprises other chemicals, such as fragrances and viscosity modifiers.

[0009] Also disclosed herein are articles loaded with a liquid composition. When the liquid composition remains substantially wet, the composition on the article has a color. When the solvent in the composition is substantially evaporated, the composition on the article becomes colorless.

[0010] definition

[0011] Components that can be used to perform the disclosed methods and systems are disclosed. These and other components are disclosed herein. It should be understood that when combinations, subsets, interactions, groups, etc. of these components are disclosed, although specific references to individual and collective combinations and arrangements of these components may not be explicitly disclosed, each is specifically contemplated and described herein for all methods and systems. This applies to all aspects of the application, including but not limited to the steps in the disclosed methods. Therefore, if there are multiple additional steps that can be performed, it should be understood that each of these additional steps can be performed with any specific embodiment or combination of embodiments of the disclosed methods.

[0012] As used in the specification and the appended claims, the singular forms "a", "an", and "the" include plural referents unless the context clearly indicates otherwise. Ranges may be expressed herein as from "about" one particular value and / or to "about" another particular value. When such a range is expressed, another embodiment includes from the one particular value and / or to the other particular value. Similarly, when values ​​are expressed as approximations by using the antecedent "about", it is understood that the particular value forms another embodiment. It is also understood that the endpoints of each range have significance relative to the other endpoint and are independent of the other endpoint.

[0013] "Optional" or "optionally" means that the subsequently described event or circumstance may or may not occur, and that the description includes instances where said event or circumstance occurs and instances where it does not.

[0014] Throughout the description and claims of this specification, the word "include" and its variants, such as "include" and "comprising" mean "including but not limited to", and are not intended to exclude, for example, other additives, components, integers or steps. "Exemplary" means "example" and is not intended to convey the meaning of a preferred or ideal embodiment. "Such as" is not used in a limiting sense, but for illustrative purposes.

[0015] When a range of values ​​is listed, it is intended to include every value and subrange within the range. For example, “C 1-6 "Alkyl" is intended to cover C1, C2, C3, C4, C5, C6, C 1-6 , C 1-5 , C 1-4 , C 1-3 , C 1-2 , C 2-6 , C 2-5 , C 2-4 , C 2-3 , C 3-6 , C 3-5 , C 3-4 , C 4-6 , C 4-5 and C 5-6 alkyl.

[0016] The term "alkyl" refers to a straight chain, branched chain, or cyclic hydrocarbon group having a specified range of carbon atoms (e.g., "C 1-16 "Alkyl" can have 1 to 16 carbon atoms). Unless otherwise specified, "alkyl" groups include both saturated alkyl groups and unsaturated alkyl groups. When an alkyl group is immediately preceded by the prefix "n", the alkyl group is understood to be a straight chain, non-branched alkyl group, for example, n-butyl refers to the group *-CH2CH2CH2CH3. An "alkyl" group can be a cycloalkyl group, in which all carbon atoms are part of the ring system, or only a portion of the carbons in the alkyl group are part of the ring system. Unless otherwise specified, "alkyl" groups include both cyclic alkyl groups and non-cyclic alkyl groups.

[0017] Exemplary alkyl groups include methyl (C1), ethyl (C2), propyl (C3) (e.g., n-propyl, isopropyl), butyl (C4) (e.g., n-butyl, tert-butyl, sec-butyl, isobutyl), pentyl (C5) (e.g., n-pentyl, 3-pentyl, pentyl, neopentyl, 3-methyl-2-butyl, tert-pentyl) and hexyl (C6) (e.g., n-hexyl). Other examples of alkyl groups include n-heptyl (C7), n-octyl (C8), etc. Unless otherwise indicated, an alkyl group may be unsubstituted ("unsubstituted alkyl") or substituted ("substituted alkyl") with one or more substituents (e.g., F, Cl, Br, I, OH, COOH, phenyl, etc.).

[0018] The term "aryl" refers to a monocyclic or polycyclic (e.g., bicyclic or tricyclic) 4n+2 aromatic ring system (e.g., having a total of 6, 10, or 14 π electrons in the cyclic array) radical providing 6-14 ring carbon atoms and zero heteroatoms ("C 6-14 In some embodiments, an aryl group has 6 ring carbon atoms ("C6 aryl"; e.g., phenyl). In some embodiments, an aryl group has 10 ring carbon atoms ("C 10 In some embodiments, an aryl group has 14 ring carbon atoms ("C 14 "Aryl" also includes ring systems in which the aryl ring (as defined above) contains non-aromatic carbon atoms (e.g., alkyl groups), and in such cases, the number of carbon atoms continues to refer to the number of carbon atoms in the aryl ring system. Unless otherwise indicated, each example of an aryl group is independently unsubstituted (an "unsubstituted aryl") or substituted (a "substituted aryl") with one or more substituents. In certain embodiments, an aryl group can be phenyl, 1-naphthyl, 2-naphthyl, 4-methylphenyl, 2-methylphenyl, or 4-chlorophenyl.

[0019] "Aralkyl" or "alkaryl" is a subset of "alkyl" and refers to an alkyl group substituted with an aryl group, where the point of attachment is on the alkyl portion.

[0020] The term "heteroaryl" refers to a group of a 5-14 membered monocyclic or polycyclic (e.g., bicyclic, tricyclic) 4n+2 aromatic ring system (e.g., with a total of 6, 10, or 14 π electrons in the cyclic array) that provides ring carbon atoms and 1-4 ring heteroatoms in the aromatic ring system, wherein each heteroatom is independently selected from nitrogen, oxygen, and sulfur ("5-14 membered heteroaryl"). In heteroaryl groups containing one or more nitrogen atoms, the point of attachment can be a carbon or nitrogen atom, as long as valence permits. Heteroaryl polycyclic ring systems can contain one or more heteroatoms in one or both rings. "Heteroaryl" includes ring systems in which a heteroaryl ring (as defined above) is fused to one or more carbocyclyl or heterocyclyl groups, wherein the point of attachment is on the heteroaryl ring, and in this case, the number of ring members continues to represent the number of ring members in the heteroaryl ring system. "Heteroaryl" also includes ring systems in which a heteroaryl ring (as defined above) is fused to one or more aryl groups, wherein the point of attachment is on the aryl or heteroaryl ring, and in such case the number of ring members refers to the number of ring members in the fused polycyclic (aryl / heteroaryl) ring system.

[0021] Unless otherwise expressly provided, a group is optionally substituted. The term "optionally substituted" refers to substituted or unsubstituted. "Optionally substituted" refers to a group that can be substituted or unsubstituted (e.g., "substituted" or "unsubstituted" alkyl or "substituted" or "unsubstituted" aryl). In general, the term "substituted" means that at least one hydrogen present on a group is replaced by an allowed substituent (e.g., a substituent that produces a stable compound (e.g., a compound that does not spontaneously undergo transformation such as by rearrangement, cyclization, elimination or other reactions) after substitution). Unless otherwise specified, a "substituted" group has a substituent at one or more substitutable positions of the group, and when more than one position in any given structure is substituted, the substituent can be the same or different at each position. The term "substituted" is intended to include substitutions with all allowed substituents of an organic compound, and includes any of the substituents described herein that cause the formation of a stable compound.

[0022] Exemplary substituents include, but are not limited to, -SO3H, PO3H2, -OH, -OR aa 、-N(R aa )2、-N(R aa )3 + X - and -CO2H, where X – is the counterion, where R aa Each example is independently selected from H and C 1-10 alkyl, and wherein two or more R aa The groups may together form a 3-14 membered heterocyclyl ring or a 5-14 membered heteroaryl ring,

[0023] The term "hydroxyl" or "hydroxy" refers to the group -OH.

[0024] When a compound exists in an ionized form, having one or more positively or negatively charged atoms, it is understood that the compound is accompanied by a sufficient number of counterions to ensure overall charge neutrality. Ionizable compounds (i.e., compounds capable of accepting or donating protons) can be provided in the form of acceptable salts. Examples of such salts are acid addition salts formed with inorganic acids (e.g., hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid and nitric acid, etc.); salts formed with organic acids (such as acetic acid, oxalic acid, tartaric acid, succinic acid, maleic acid, fumaric acid, gluconic acid, citric acid, malic acid, methanesulfonic acid, p-toluenesulfonic acid, naphthalenesulfonic acid, polygalacturonic acid, etc.); salts formed with elemental anions (such as chloride, bromide and iodide); salts formed with metal hydroxides (e.g., sodium hydroxide, potassium hydroxide, calcium hydroxide, lithium hydroxide and magnesium hydroxide); salts formed with metal carbonates (e.g., sodium carbonate, potassium carbonate, calcium carbonate and magnesium carbonate); salts formed with metal bicarbonates (e.g., sodium bicarbonate and potassium bicarbonate); salts formed with metal sulfates (e.g., sodium sulfate and potassium sulfate); and salts formed with metal nitrates (e.g., sodium nitrate and potassium nitrate). Suitable counterions include the conjugate acids and conjugate bases of the aforementioned inorganic acids, organic acids, metal hydroxides, metal carbonates, and metal sulfates.

[0025] To evaluate the performance and characteristics of the disclosed embodiments, certain analyses may be performed under "standard conditions". As used herein, "standard conditions" refers to 23°C and a pressure of 1 atm. Unless otherwise indicated, "flat surface" refers to any impermeable substrate upon which a liquid may be deposited, wherein, after depositing a specified amount of liquid (e.g., 1 ml), the liquid may diffuse freely without encountering the edges, sidewalls, or other topological deviations from the flat surface.

[0026] Cyanine dyes are compounds with two trisubstituted nitrogen atoms conjugated to each other via a (poly)methine chain, one of the two nitrogen atoms being in the oxidized (imine) form. Cyanine dyes have the following general structure:

[0027]

[0028] wherein n is 0-6, each * is independently any alkyl, aryl or heteroaryl group, and each # is independently H, F, Cl, Br, I, COOH, alkoxy, alkyl, aryl or heteroaryl group, wherein any two or more * and # groups may be taken together to form a ring. Counter anions are present but not shown and may be present as separate ionic species (e.g., F - , Cl - Br- ,I - The poly(methine) chains generally adopt the most thermodynamically stable configuration (e.g., all-trans), however, unless otherwise indicated, the description of the olefin in one geometric configuration does not exclude any other possible geometric configurations.

[0029] The trisubstituted nitrogen atom in cyanine can be acyclic, for example, neither of the two * groups attached to the nitrogen atom forms a ring system with each other or with adjacent # groups. In other embodiments, the nitrogen atom can be part of a ring system, such as:

[0030]

[0031] Cyanine dyes in which both nitrogen atoms are part of a ring system are called closed-chain cyanines, compounds in which one nitrogen atom is part of a ring system are called hemicyanines, and compounds in which neither nitrogen atom is part of a ring system are called chain cyanines. Compounds in which "n" is 0 are called apocyanines.

[0032] Merocyanine dyes are compounds with a trisubstituted nitrogen atom conjugated to a carbonyl or similar electron-accepting group:

[0033]

[0034] wherein X is O, S or N (imide or cyano).

[0035] As used herein, "eliminate" in the context of a disinfectant or sanitizer means to kill, eradicate, prevent the growth of, or inactivate pathogens.

[0036] As used herein, "disinfection" refers to the process of eliminating bacteria, optionally along with the elimination of one or more other pathogens.

[0037] As used herein, "sterilization" refers to the process of eliminating bacteria and viruses, optionally accompanied by the elimination of one or more other pathogens. DETAILED DESCRIPTION

[0038] Liquid compositions are disclosed herein. The compositions can be used to disinfect and / or sterilize surfaces. The compositions can include solvents, active agents, acids, and indicator compounds. The compositions can be applied to surfaces (e.g., by spraying or transferring from cleaning products) to eliminate pathogens on the surfaces. The indicator compound provides a visible color for the composition in a wet state, and the compound has at least one maximum absorption value in the visible light region. Once applied to the surface, when the composition is substantially dry, a color change transition (e.g., from colored to colorless) will occur.

[0039] Composition

[0040] The compositions disclosed herein may include one or more solvents. In certain embodiments, the solvent is an organic solvent. In some embodiments, the solvent is a volatile organic solvent. In some embodiments, the organic solvent has (at 1 atm) a boiling point of less than 150°C, less than 140°C, less than 130°C, less than 120°C, less than 110°C, less than 100°C, less than 90°C, less than 80°C, less than 70°C, less than 60°C or less than 50°C. In other embodiments, the organic solvent has (at 1 atm) a boiling point of 50°C-150°C, 50°C-75°C, 75°C-100°C, 100°C-125°C, 125°C-150°C, 50°C-100°C, 75°C-125°C or 100°C-150°C. In some preferred embodiments, the solvent is an organic solvent with a boiling point of 120°C or less.

[0041] In some embodiments, the organic solvent comprises an alcohol, such as C 1-8 Alkyl alcohol, C 1-6 Alkyl alcohol, C 1-4 Alkyl alcohol or C 1-2 Alkyl alcohol. In certain embodiments, the organic solvent is an alkyl alcohol with a single hydroxyl group, while in other embodiments, the organic solvent is an alkyl alcohol with two hydroxyl groups. Exemplary alkyl alcohols include methanol, ethanol, propanol, isopropanol, butanol, sec-butyl alcohol, tert-butyl alcohol, isobutyl alcohol, amyl alcohol, isoamyl alcohol, 2-methyl-1-butanol, neopentyl alcohol, 2-pentanol, 3-methyl-2-butanol, 3-pentanol, tert-pentanol, 2-hexanol, 3-hexanol, 2-methyl-1-pentanol, 3-methyl-1-pentanol, 4-methyl-1-pentanol, 2-methyl-2-pentanol, 3-methyl-2-pentanol, 4-methyl-2-pentanol, 2-methyl-3-pentanol, 3-methyl-3-pentanol, 2,2-dimethyl-1-butanol, 2,3-dimethyl-1-butanol, 3,3-dimethyl-1-butanol, amyl alcohol, hexanol, octanol, etc.

[0042] In some embodiments, the organic solvent comprises a ketone or an ester, such as C 1-8 Ketone, C1-6 Ketone, C 1-4 Ketone, C 1-2 Ketone, C 1-8 Ester, C 1-6 Ester, C 1-4 Ester or C 1-2 Esters. Exemplary ketones include acetone, methyl ethyl ketone (2-butanone), and the like. Exemplary esters include ethyl acetate, methyl acetate, isopropyl acetate, butyl acetate, and the like. In further embodiments, the organic solvent may include a mixed ester / ketone, such as 1-acetoxyacetone.

[0043] In some embodiments, the composition comprises water, either as the sole solvent or in combination with one or more organic solvents as defined above. In other embodiments, the composition does not comprise water. As used herein, a composition not comprising water does not mean excluding compositions containing incidental water (e.g., residual water present in commercially available solvents).

[0044] In some embodiments, the composition contains water in an amount of 0%-5%, 0%-2.5%, 0%-1.5%, 0%-1%, 0%-0.5%, 0%-0.25%, or 0%-0.1% (v / v). In other embodiments, water may be present in an amount of 5%-95%, 5%-50%, 5%-25%, 5%-15%, 5%-10%, 10%-20%, 15%-30%, 25%-50%, 40%-60%, 25%-75%, 50%-75%, 50%-95%, 75%-95%, 80%-95%, or 90%-95% (v / v).

[0045] Compositions disclosed herein may include one or more active agents with disinfection and / or bactericidal capabilities. For example, compositions may include one or more antibacterial agents, antiviral agents, antifungal agents and / or antiparasitic agents. It is understood by the technician that many compounds show a series of activities against different types of organisms. Therefore, unless otherwise clearly indicated, referring to an active agent as a bactericide does not exclude compounds having additional activity (e.g., having bactericidal activity and fungicidal activity simultaneously).

[0046] In some cases, the composition can include an amount of 0.01% to 25% by weight of the active agent (relative to the gross weight of the composition). For example, the composition can include an amount of 0.01% to 5% by weight, 0.1% to 5% by weight, 0.1% to 2.5% by weight, 0.5% to 5% by weight, 1% to 2.5% by weight, 1% to 5% by weight, 2.5% to 7.5% by weight, 2.5% to 10% by weight, 5% to 15% by weight, 5% to 10% by weight, 10% to 15% by weight, 10% to 20% by weight, 10% to 25% by weight, or 15% to 25% by weight of the active agent.

[0047] In certain embodiments, the active agent may include a quaternary ammonium compound ("quat"). A quaternary ammonium compound may be a compound having the formula:

[0048]

[0049] Where R q1 , R q2 , R q3 and R q4 Independently selected from C 1-20 Alkyl, C 0-4 Alkyl and C 0-4 Alkyl heteroaryl, where R q1 , R q2 , R q3 and R q4 Any two or more of may together form a saturated ring or an unsaturated ring, and X q is an acceptable anion. Preferred C 0-4 Alkaryl groups include phenyl, benzyl and 2-phenylethyl. q1 , R q2 , R q3 and R q4 may be optionally substituted one or more times with groups such as aryl, hydroxyl, carboxylate, or oxo. q3 and R q4 can form a piperidine ring together. In some embodiments, R q2 , R q3 and R q4 Together they may form a pyridinium, imidazolinium, pyrrolidinium or [2.2.2]bicyclooctyl ring.

[0050] Preferred X q Groups include chloride, bromide, iodide, sulfate, propionate, methylsulfate, saccharinate, ethylsulfate, hydroxide, acetate, phosphate, carbonate, bicarbonate, salicylate, and nitrate.

[0051] In certain embodiments, R q2 , R q3 and R q4 Each independently selected from C 1-4 alkyl, preferably methyl or ethyl, and R q1 It is C 6-20 Alkyl or C 0-4 Alkaryl, preferably benzyl, phenyl or 2-phenylethyl. In some embodiments, R q3 and R q4 Each is a methyl group, R q2 It is C 4-10 Alkyl, and R q1 It is C 7-20 Alkyl or C 0-4 Alkyl.

[0052] Exemplary quaternary ammonium compounds include alkyl dimethyl benzyl ammonium chloride, alkyl dimethyl ethyl benzyl ammonium chloride, octyl decyl dimethyl ammonium chloride, dioctyl dimethyl ammonium chloride, didecyl dimethyl ammonium chloride, benzethonium chloride, ethyl benzyl alkyl ammonium chloride, ethyl benzethonium chloride, myristyl trimethyl ammonium chloride, methyl benzethonium chloride, cetaxonium chloride, cetrimide, cetrimonium bromide (CTAB), carnitine, dequalinium chloride, dofadumium chloride, tetraethylammonium bromide (TEAB), domiphene bromide, octenidine dihydrochloride, cetrimide, benzododecyl ammonium bromide, benzozolium chloride, choline, and denatonium.

[0053] The composition can include a quaternary ammonium compound in an amount of 0.01% to 5%, 0.1% to 5%, 0.1% to 2.5%, 0.5% to 5%, 1% to 2.5%, 1% to 5%, 2.5% to 7.5%, 2.5% to 10%, 5% to 15%, 5% to 10%, 10% to 15%, 10% to 20%, 10% to 25%, or 15% to 25%. In other embodiments, the composition does not include a quaternary ammonium compound.

[0054] The composition may include one or more biguanide compounds, including polyhexanide. In some embodiments, the biguanide may have the following formula:

[0055]

[0056] Where R g and R g* One of them is H, the other is H, aryl, alkyl or heteroaryl, and Z is (CH2) z, and z is 0-12, 2-12, 2-10, 2-8, 4-8 or 4-6p, preferably 4, 5 or 6. In some embodiments, R g and R g* One of them is H and the other is aryl, alkyl or heteroaryl. The skilled person understands that such biguanides may also exist as tautomers (e.g., tautomer 1: R g is H, and R g* is aryl, alkyl or heteroaryl; and tautomer 2: R g* is H, and R g These tautomers can be interconverted according to thermodynamics and chemical environment, and, unless otherwise indicated, representation of one tautomeric form includes the other tautomeric form. In certain preferred embodiments, R g and R g* In other embodiments, one of R is aryl (e.g., phenyl, 2-chlorophenyl, 4-chlorophenyl, 4-methylphenyl, 4-trifluoromethoxyphenyl, especially 4-chlorophenyl). g and R g* One of them is C 1-18 Alkyl, preferably C 3-12 Alkyl, C 4-10 Alkyl, C 4-8 Alkyl or C 6-8 Alkyl, even more preferably unsubstituted C 3-12 Alkyl, unsubstituted C 4-10 Alkyl, unsubstituted C 4-8 Alkyl or unsubstituted C 6-8 alkyl.

[0057] The composition can include biguanide in an amount of 0.01% to 5%, 0.1% to 5%, 0.1% to 2.5%, 0.5% to 5%, 1% to 2.5%, 1% to 5%, 2.5% to 7.5%, 2.5% to 10%, 5% to 15%, 5% to 10%, 10% to 15%, 10% to 20%, 10% to 25%, or 15% to 25% by weight. In other embodiments, the composition does not include biguanide.

[0058] Exemplary biguanides include ethylene biguanide, propylene biguanide, tetramethylene biguanide, pentamethylene biguanide, hexamethylene biguanide, heptamethylene biguanide, octamethylene biguanide, 1,6-bis-(4-chlorobenzylbiguanide)-hexane 1,1′-hexamethylenebis(5-(p-chlorophenyl)biguanide)(chlorhexidine), 2-(benzyloxymethyl)pentane-1,5-bis(5-hexylbiguanide), 2-(phenylthiomethyl)pentane-1,5-bis(5-phenylethylbiguanide), 3-(phenylthio)hexane-1,6-bis(5-hexylbiguanide), 3-(phenylthio)hexane-1,6-bis(5-cyclohexylbiguanide), 3-(benzylthio)hexane-1,6-bis(5-hexylbiguanide) and 3-(benzylthio)hexane biguanide, 1,6-bis(5-cyclohexylbiguanide), phenylbiguanide, naphthylbiguanide, pyridylbiguanide, piperazinylbiguanide, phthaloylbiguanide, 1,1′-[4-(dodecyloxy)-m-phenylene]biguanide, 2-(decylthiomethyl)pentane-1,5-bis(5-isopropylbiguanide), 2-(decylthiomethyl)pentane-1,5-bis(5,5-diethylbiguanide), alexidine, salts thereof, and combinations thereof.

[0059] In some embodiments, the composition can include one or more surfactants. Exemplary surfactants include nonionic surfactants and ionic surfactants, such as cationic surfactants, anionic surfactants and zwitterionic surfactants. The composition can include an amount of 0.01% by weight-5% by weight, 0.1% by weight-5% by weight, 0.1% by weight-2.5% by weight, 0.5% by weight-5% by weight, 1% by weight-2.5% by weight, 1% by weight-5% by weight, 2.5% by weight-7.5% by weight, 2.5% by weight-10% by weight, 5% by weight-15% by weight, 5% by weight-10% by weight, 10% by weight-15% by weight, 10% by weight-20% by weight, 10% by weight-25% by weight or 15% by weight-25% by weight of surfactant. In other embodiments, the composition does not include surfactant.

[0060] In certain embodiments, the composition comprises one or more anionic surfactants, such as sulfonate surfactants, carboxylate surfactants, or sulfate surfactants. Exemplary anionic surfactants include sodium alkyl sulfates and sodium sulfonates. Suitable carboxylate surfactants include fatty acids (such as C 8-24 In some cases, the anionic surfactant is sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, sodium laurate, sodium lauryl sulfate, sodium lauryl sarcosinate, potassium lauryl sulfate, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylene sulfonate, magnesium lauryl sulfate, sodium myristyl sulfate, sodium nonanoyloxybenzene sulfonate or ammonium xylene sulfonate.

[0061] The composition can include an anionic surfactant in an amount of 0.01% to 5% by weight, 0.1% to 5% by weight, 0.1% to 2.5% by weight, 0.5% to 5% by weight, 1% to 2.5% by weight, 1% to 5% by weight, 2.5% to 7.5% by weight, 2.5% to 10% by weight, 5% to 15% by weight, 5% to 10% by weight, 10% to 15% by weight, 10% to 20% by weight, 10% to 25% by weight, or 15% to 25% by weight. In other embodiments, the composition does not include an anionic surfactant.

[0062] In some embodiments, the composition comprises one or more nonionic surfactants. In some embodiments, the nonionic surfactant is C 7-24 Fatty acid esters, C 10-24 Fatty alcohol ether, C 8-24 Amine oxides, nonylphenol polyoxyethylene ethers, alkyl polyglucosides (e.g., 5-18 Alkyl chain). Exemplary nonionic surfactants include cetyl alcohol, stearyl alcohol, cetearyl alcohol and oleyl alcohol, poloxamers (block copolymers of polyethylene glycol and polypropylene glycol), ethoxylated fatty alcohols (such as PEG-80 sorbitan laurate), polyoxyethylene glycol alkyl ethers (such as pentaethylene glycol monododecyl ether, octaethylene glycol monododecyl ether, polyoxypropylene glycol alkyl ether, glucoside alkyl ethers, polyoxyethylene glycol octylphenol ether, polyoxyethylene glycol alkylphenol ether (such as nonoxynol-9)), glyceryl alkyl esters (such as glyceryl laurate), polyoxyethylene glycol sorbitan alkyl esters (such as polysorbates, sorbitan alkyl esters), cocamide MEA, cocamide DEA, amine oxides (such as dodecyl dimethylamine oxide, polyethoxylated tallow amine), and mixtures thereof.

[0063] The composition can include an amount of 0.01% to 5% by weight, 0.1% to 5% by weight, 0.1% to 2.5% by weight, 0.5% to 5% by weight, 1% to 2.5% by weight, 1% to 5% by weight, 2.5% to 7.5% by weight, 2.5% to 10% by weight, 5% to 15% by weight, 5% to 10% by weight, 10% to 15% by weight, 10% to 20% by weight, 10% to 25% by weight, or 15% to 25% by weight of a nonionic surfactant. In other embodiments, the composition does not include a nonionic surfactant.

[0064] In some embodiments, the composition comprises one or more zwitterionic surfactants. Exemplary zwitterionic surfactants include betaines (such as cocamidopropyl betaine), sultaines (such as cocamidopropyl hydroxysultaine and lauramidopropyl hydroxysultaine), amphoacetates and amphodiacetates (such as disodium lauroamphodiacetate, disodium cocoamphodiacetate, sodium lauroamphoacetate, sodium cocoamphoacetate, disodium cocoamphodipropionate, and disodium lauroamphodipropionate). In some embodiments, the composition may include one or more zwitterionic surfactants selected from 4-[N,N-di(2-hydroxyethyl)-N-octadecylammonium]-butane-1-carboxylate, S-[S-3-hydroxypropyl-S-hexadecylsulfonium]-3-hydroxypentane-1-sulfate, 3-[P,P-diethyl-P-3,6,9-trioxatetradecylphosphonium]-2-hydroxypropane-1-phosphate, 3-[N,N-dipropyl-N-3-dodecyloxy-2-hydroxypropylammonium]-propane-1-phosphonate, 3-(N,N-dimethyl-N-hexadecylsulfonium]-3-hydroxypentane-1-sulfate. ammonium) propane-1-sulfonate, 3-(N,N-dimethyl-N-hexadecyl ammonium)-2-hydroxypropane-1-sulfonate, 4-[N,N-di(2-hydroxyethyl)-N-(2-hydroxydodecyl)ammonium]-butane-1-carboxylate, 3-[S-ethyl-S-(3-dodecyloxy-2-hydroxypropyl)sulfonium]-propane-1-phosphate, 3-[P,P-dimethyl-P-dodecylphosphonium]-propane-1-phosphonate, 5-[N,N-di(3-hydroxypropyl)-N-hexadecylammonium]-2-hydroxy-pentane-1-sulfate, lauryl hydroxysulfobetaine, and combinations thereof.

[0065] The composition can include a zwitterionic surfactant in an amount of 0.01 wt%-5 wt%, 0.1 wt%-5 wt%, 0.1 wt%-2.5 wt%, 0.5 wt%-5 wt%, 1 wt%-2.5 wt%, 1 wt%-5 wt%, 2.5 wt%-7.5 wt%, 2.5 wt%-10 wt%, 5 wt%-15 wt%, 5 wt%-10 wt%, 10 wt%-15 wt%, 10 wt%-20 wt%, 10 wt%-25 wt%, or 15 wt%-25 wt%. In other embodiments, the composition does not include a zwitterionic surfactant.

[0066] The disclosed compositions may include one or more acids, such as C substituted with one or more carboxylic acids. 1-12Alkyl groups, aromatic rings and heteroaryl rings. In some embodiments, the composition includes one or more compounds with a single acidic group (e.g., a single carboxylic acid). Such compounds may be referred to as monoprotic acids. Exemplary monoprotic acids include gluconic acid and picolinic acid. In other embodiments, the composition includes compounds with two or more acidic groups. Such compounds may be referred to as polyacids. Exemplary compounds with two acidic groups include phthalic acid, fumaric acid, tartaric acid, malic acid, maleic acid and glutaric acid. In other embodiments, acid is a compound with three acidic groups. Exemplary compounds with three acidic groups include citric acid and trimesic acid. The composition may include acids with more than three acidic groups, such as phytic acid and mellitic acid.

[0067] The composition may comprise an acid with a pKa of 0-6.5, 1-6.5, 2-6.5, 3-6.5, 4-6.5, 5-6.5, 1-3, 2-4, or 3-5 (measured in water at 23° C.) For compounds with more than one acidic group, the pKa relates to the dissociation of the most acidic proton.

[0068] In some embodiments, composition can include one or more non-volatile acids. As used herein, non-volatile acids are compounds that do not evaporate substantially under standard conditions. In some embodiments, non-volatile acids can have (at 1 atm) a boiling point of at least 100°C, at least 125°C, at least 150°C, at least 200°C, at least 250°C, at least 300°C, at least 350°C, or at least 400°C. In some embodiments, non-volatile acids can have a melting point of at least 75°C, at least 100°C, at least 125°C, at least 150°C, at least 175°C, at least 200°C, at least 250°C, or at least 300°C.

[0069] In certain embodiments, the composition can include one or more acids selected from the group consisting of adipic acid, ascorbic acid, phthalic acid, benzoic acid, butyric acid, citric acid, toluic acid, capric acid, caproic acid, cyanuric acid, dihydroacetic acid, 2-ethyl-hexanoic acid, formic acid, fumaric acid, gluconic acid, glycolic acid, 1-glutamic acid, isopropylaminosulfonic acid, lactic acid, maleic acid, malic acid, methanesulfonic acid, cyclohexane acid, oxalic acid, phytic acid, propionic acid, salicylic acid, sorbic acid, tartaric acid, valeric acid, and combinations thereof.

[0070] In a preferred embodiment, the acid is selected from tartaric acid, fumaric acid, citric acid and malic acid.

[0071] Acid can be used in 0.05mg / ml-50mg / ml, 10mg / ml-50mg / ml, 25mg / ml-50mg / ml, 10mg / ml-25mg / ml, 0.05mg / ml-25 mg / ml, 0.05mg / ml-10mg / ml, 0.1mg / ml-10mg / ml, 0.5mg / ml-10mg / ml, 1mg / ml-10mg / ml, 2mg / ml-10 The composition is present in a concentration of 2.5 mg / ml, 4 mg / ml-10 mg / ml, 5 mg / ml-10 mg / ml, 7.5 mg / ml-10 mg / ml, 0.05 mg / ml-2.5 mg / ml, 0.1 mg / ml-2.5 mg / ml, 0.5 mg / ml-2.5 mg / ml, 1 mg / ml-2.5 mg / ml, 1 mg / ml-5 mg / ml or 2.5 mg / ml-5 mg / ml.

[0072] The disclosed compositions include one or more indicators. The indicator can be a dye, such as a polymethine dye. In certain embodiments, the indicator is a cyanine dye. In some embodiments, the indicator is a chain cyanine, a hemicyanine, a closed chain cyanine, a merocyanine, an apocyanine, or a combination thereof.

[0073] In certain embodiments, the indicator is a quinocyanine, an isoquinocyanine, or a mixed quinocyanine / isoquinocyanine. Quinocyanine is a closed chain cyanine in which each nitrogen atom forms part of a quinoline ring. Isoquinocyanine is a closed chain cyanine in which each nitrogen atom forms part of an isoquinoline ring. Mixed quinocyanine / isoquinocyanine is a closed chain cyanine in which one nitrogen atom forms part of a quinoline ring and another nitrogen atom forms part of an isoquinoline ring. Exemplary quinocyanines, isoquinocyanines, and mixed quinocyanine / isoquinocyanines include compounds such as the following:

[0074]

[0075] (counter anion, not depicted), wherein n is 0-6, R c is optionally substituted C 1-8 alkyl, X is an acceptable anion, z is 0-6, and R is independently selected from F, Cl, Br, I, OH, COOH, CN, C 1-8 Alkyl, aryl, C 1-8 Alkoxy, NH2, NHC 1-8 Alkyl and N(C 1-8 Preferably, z is 0 or 1, most preferably 0. Acceptable counter anions include chloride, bromide or iodide. Preferably, n is 1-3, even more preferably 1-2, especially 1.

[0076] In other embodiments, the indicator may be a compound having the formula:

[0077]

[0078] wherein n, X, R and Rc are as defined above, z* is 0-4, and Z is C(CH 3 )2, O, S or NCH3. Preferably, z* is 0 or 1, most preferably 0.

[0079] In some embodiments, R c can be substituted one or more times with solubility regulating groups such as phenyl, N(CH3)2, OH, COOH, [(CH3)3N + ], SO3H or PO3H2 (and its salts). c Embodiments substituted with ionizable groups capable of carrying a negative charge (eg, COOH, SO3H, or PO3H2) do not require the presence of a separate counterion, as long as the compound is electrochemically balanced.

[0080] In some embodiments, the indicator is wherein Z=C(CH3)2, n=1, 2 or 3, and R c It is a compound of ethyl, methyl, butyl or 4-sulfonylbutyl.

[0081] Acid and indicator can be combined in various ratios. For example, the composition can include an acid and an indicator in a weight ratio of 1:1 to 500:1, 1:1 to 250:1, 1:1 to 100:1, 1:1 to 75:1, 1:1 to 50:1, 1:1 to 40:1, 1:1 to 30:1, 1:1 to 20:1, 1:1 to 10:1, 5:1 to 50:1, 10:1 to 25:1, 10:1 to 50:1, 20:1 to 50:1, 25:1 to 50:1, 25:1 to 75:1, 50:1 to 100:1, 50:1 to 150:1, or 100:1 to 500:1. For embodiments in which there are multiple indicators and / or acids, the weight ratios disclosed herein refer to the total amount of each component.

[0082] In certain embodiments, the composition may include one or more compounds selected from propionic acid and its salts; salicylic acid and its salts; sorbic acid and its salts; benzoic acid and its salts and esters; formaldehyde; paraformaldehyde; o-phenylphenol and its salts; zinc pyrithione; inorganic sulfites; bisulfites; chlorobutanol; parabens such as methylparaben, propylparaben, butylparaben, ethylparaben, isopropylparaben, isobutylparaben, benzylparaben, sodium methylparaben and sodium propylparaben; dehydroacetic acid and its salts; formic acid and its salts; dibromohexidine isethionate salts; thimerosal; phenylmercuric salts; undecylenic acid and its salts; hexetidine; 5-bromo-5-nitro-1,3-dioxane; 2-bromo-2-nitropropane-1,3-diol; dichlorobenzyl alcohol; triclocarban; p-chlorometa-cresol; triclosan; chloroxylenol; imidazolidinyl urea; polyaminopropyl biguanide; phenoxyethanol, methenamine; quaternary ammonium salt-15; climbazole; DMDM ​​hydantoin; benzyl alcohol; hydroxymethyloctopirox olamine; bromochlorfen; o-cymene-5-ol; methylchloroisothiazolinone; methylisothiazolinone; benzylchlorophenol; chloroacetamide; chlorhexidine; chlorhexidine diacetate; chlorhexidine digluconate; chlorhexidine dihydrochloride; phenoxyisopropanol; alkyl (C 12-22 )trimethylammonium bromide and chloride; dimethyloxazolidine; diazolidinyl urea; hexamidine; hexamidine diisethionate; glutaraldehyde; 7-ethylbicyclic oxazoline; chlorphenesin; sodium hydroxymethylglycinate; silver chloride; benzethonium chloride; benzalkonium chloride; benzalkonium bromide; formaldehyde benzyl alcohol hemiacetal; iodopropynyl butylcarbamate; ethyl lauroyl arginine hydrochloride; citric acid; and silver citrate.

[0083] The composition can be formulated at different acidic pH levels. In certain embodiments, the composition has a pH of 1-6, 2-5, 2-4, 3-8, or 4-5.

[0084] The disclosed compositions can include an antioxidant such as butylated hydroxytoluene, ascorbic acid, ascorbyl palmitate, butylated hydroxyanisole, 2,4,5-trihydroxybutyrophenone, 4-hydroxymethyl-2,6-di-tert-butylphenol, isoascorbic acid, guaiac gum, propyl gallate, thiodipropionic acid, dilauryl thiodipropionate, t-butylhydroquinone, tocopherol, sodium metabisulfite, sodium sulfite, or a combination thereof. The antioxidant may be present in the composition in an amount of 0.01 wt %-1.0 wt %, 0.01 wt %-0.75 wt %, 0.01 wt %-0.5 wt %, 0.01 wt %-0.25 wt %, 0.01 wt %-0.1 wt %, 0.05 wt %-0.15 wt %, 0.1 wt %-1.0 wt %, 0.1 wt %-0.5 wt %, 0.1 wt %-0.25 wt %, 0.25 wt %-1.0 wt %, 0.5 wt %-1.0 wt % or 0.25 wt %-0.75 wt %. In other embodiments, the composition does not include an antioxidant.

[0085] The composition can be formulated with a viscosity suitable for application to a surface. The viscosity can be measured at a shear rate of 1 Hz at 23° C. The suitable viscosity of the composition includes 1 cps-500 cps, 250 cps-500 cps, 100 cps-500 cps, 100 cps-250 cps, 100 cps-200 cps, 1 cps-250 cps, 1 cps-100 cps, 1 cps-75 cps, 1 cps-50 cps, 1 cps-25 cps, 1 cps-20 cps, 1 cps-15 cps, 1 cps-10 cps, 5 cps-25 cps, 5 cps-50 cps, 10 cps-50 cps or 10 cps-100 cps.

[0086] The composition may include one or more viscosity modifiers to provide the aforementioned rheological properties. Suitable viscosity modifiers include cellulose (including cellulose derivatives, such as methylcellulose, ethylcellulose, hydroxypropyl methylcellulose, carboxymethylcellulose, etc.), gum, poly (methyl) acrylate, starch, polyethylene glycol, etc. In some embodiments, the composition includes one or more PEG-stearate, PEG-distearate or PEG-isostearate. In some embodiments, the composition includes one or more xanthan gum, guar gum, potato starch or corn starch. In some embodiments, the composition includes polyacrylamide methyl propane sulfonic acid, polyvinyl pyrrolidone (PVP) or butylated PVP. In some embodiments, the composition does not include a viscosity modifier. The viscosity modifier may be present in the composition in an amount of 0.01 wt%-10.0 wt%, 0.01 wt%-5.0 wt%, 0.01 wt%-2.5.0 wt%, 0.01 wt%-1.0 wt%, 0.01 wt%-0.5 wt%, 0.1 wt%-1.0 wt%, 0.1 wt%-2.5 wt%, 1.0 wt%-2.5 wt%, 1.0 wt%-5.0 wt%, 2.5 wt%-5.0 wt%, 2.5 wt%-7.5 wt%, 5.0 wt%-10.0 wt%, or 7.5 wt%-10 wt%.

[0087] In some embodiments, the composition may include one or more spices. The spices may be present in an amount of no more than 5 wt%, no more than 4 wt%, no more than 3 wt%, no more than 2 wt%, no more than 1 wt%, no more than 0.75 wt%, no more than 0.5 wt%, no more than 0.25 wt%, no more than 0.1 wt%, or no more than 0.05 wt%. In other embodiments, the composition does not include spices.

[0088] Disclosed compositions provide with the colored state of absorbing the light in the visible light region.In some embodiments, compositions have between 400nm-750nm, between 400nm-700nm, between 400nm-600nm, between 400nm-500nm, between 400nm-600nm, between 450nm-550nm, between 450nm-550nm, between 500nm-600nm, between 500nm-700nm, between 550nm-650nm, between 600nm-700nm or the maximum absorption value between 650nm-750nm.In certain embodiments, compositions has single maximum absorption value in the region between 400nm-750nm.When being exposed to standard conditions, compositions can be variable color. For example, after exposure to standard conditions for a period of 180 seconds, the maximum absorbance may be reduced by at least 80%, at least 85%, at least 90%, at least 95%, at least 97.5%, or at least 99%. A clear, colorless solution indicates that the maximum absorbance has been reduced or eliminated.

[0089] Composition disclosed herein can be discolored in combination with evaporation process.By selecting the specific evaporation time of composition, discoloration time can also be controlled.In certain embodiments, when 1ml composition is applied to flat surface under standard conditions, composition will be less than 300 seconds, less than 240 seconds, less than 210 seconds, less than 180 seconds, less than 150 seconds, less than 120 seconds, less than 90 seconds, less than 75 seconds, less than 60 seconds, less than 45 seconds, less than 30 seconds or less than 15 seconds time period and evaporate to constant weight.In some embodiments, when 1ml composition is applied to flat surface under standard conditions, at least 95% of composition will be less than 300 seconds, less than 240 seconds, less than 210 seconds, less than 180 seconds, less than 150 seconds, less than 120 seconds, less than 90 seconds, less than 75 seconds, less than 60 seconds, less than 45 seconds, less than 30 seconds or less than 15 seconds time period and evaporate.

[0090] Cleaning Products

[0091] The disclosed compositions can be deployed in a variety of forms, including by spraying or by transfer from a cleaning article (eg, a substrate such as a wipe, cloth, sponge, etc.).

[0092] As used herein, the term "substrate" is intended to include any material that can absorb and release the disclosed composition. Examples of substrates include, but are not limited to, woven fabrics, nonwoven fabrics, sponges, films, and similar materials. In some cases, the substrate can be attached to a cleaning tool (e.g., a brush). In some cases, the substrate can be a wipe, such as a woven fabric or a nonwoven fabric.

[0093] Exemplary matrix fabrics include wood pulp fibers, natural polymers, and synthetic polymers. Exemplary wood pulps include chemical pulps such as kraft pulp, sulfite pulp, and sulfate pulp, and mechanical pulps, including, for example, groundwood pulp, thermomechanical pulp, and chemically modified thermomechanical pulp. Wood pulp can come from deciduous trees (hardwood pulp) and / or coniferous trees (softwood pulp). Exemplary natural polymers include starch, starch derivatives, cellulose and cellulose derivatives, hemicellulose and hemicellulose derivatives. Exemplary synthetic polymers include polyethylene, polypropylene, poly(lactic acid), poly(vinyl pyrrolidone), poly(caprolactone), polyester, polystyrene, and poly(hydroxyalkanoate). In some embodiments, synthetic polymers include polyvinyl chloride, polyvinyl fluoride, polytetrafluoroethylene, polyvinylidene chloride, polyacrylic acid (such as ), polyvinyl acetate, Polyethylvinyl acetate, insoluble or soluble polyvinyl alcohol, polyolefins (such as polyethylene (e.g., ) and polypropylene), polyamides (such as nylon), polyesters (such as or ), polyurethane, polystyrene and combinations thereof.

[0094] In some embodiments, the fabric may be only one of wood pulp fibers, natural polymers, or synthetic polymers, while in other embodiments, the fabric may include a mixture of two or more types of materials. For example, the fabric may include a synthetic polymer in an amount of 1 wt %-99 wt %, 10 wt %-90 wt %, 50 wt %-95 wt %, 5 wt %-50 wt %, 1 wt %-25 wt %, 25 wt %-50 wt %, 50 wt %-75 wt %, 75 wt %-99 wt %, or 40 wt %-60 wt % (based on dry fabric), and the balance being wood pulp fibers and / or natural fibers. In other embodiments, the fabric may comprise wood pulp in an amount of 1 wt%-99 wt%, 10 wt%-90 wt%, 50 wt%-95 wt%, 5 wt%-50 wt%, 1 wt%-25 wt%, 25 wt%-50 wt%, 50 wt%-75 wt%, 75 wt%-99 wt%, or 40 wt%-60 wt% (on a dry fabric basis), with the balance being synthetic and / or natural fibers.

[0095] In certain embodiments, the substrate can be a fiber web, such as a wet-laid tissue fiber web or an air-laid fiber web. Particularly preferred application devices include fiber webs, including nonwoven fiber webs of cellulose fiber webs and synthetic fiber materials. Available fiber webs can be wet-laid fiber webs, air-laid fiber webs, melt-blown fiber webs or spunbond fiber webs. Suitable synthetic fiber materials include melt-blown polyethylene, polypropylene, copolymers of polyethylene and polypropylene, bicomponent fibers comprising polyethylene or polypropylene, etc. Available nonwoven fiber webs can be melt-blown fiber webs, spun fiber webs, spunbond fiber webs, air-laid fiber webs, spunlace entangled nonwoven fiber webs, spunlace fiber webs, bonded carded fiber webs.

[0096] The composition can be added to the matrix in different amounts. For example, the composition can be loaded / absorbed onto the matrix in an amount of at least 100 wt %, at least 150 wt %, at least 200 wt %, at least 300 wt %, at least 400 wt %, at least 500 wt %, at least 600 wt %, at least 700 wt %, at least 800 wt %, at least 900 wt % or at least 1,000 wt % relative to the dry weight of the matrix. In certain embodiments, the composition can be loaded / absorbed onto the substrate in an amount of 50 wt%-1,000 wt%, 100 wt%-1,000 wt%, 200 wt%-1,000 wt%, 100 wt%-1,000 wt%, 200 wt%-1,000 wt%, 100 wt%-1,000 wt%, 200 wt%-1,000 wt%, 300 wt%-1,000 wt%, 400 wt%-1,000 wt%, 500 wt%-1,000 wt%, 600 wt%-1,000 wt%, 750 wt%-1,000 wt%, 100 wt%-500 wt%, or 250 wt%-750 wt% relative to the dry weight of the substrate.

[0097] The disclosed compositions can be used to determine whether a disinfecting and / or sterilizing composition has been applied to a given surface (by applying the composition to the surface and visually determining (by the presence of a colored liquid) whether the surface covers an area of ​​interest). Also disclosed are methods for determining whether a substrate is loaded with a disinfecting and / or sterilizing composition sufficient to ensure transfer of an effective amount of the composition from the substrate to the surface. The visual appearance of a colored composition indicates that there is sufficient liquid to ensure effective transfer of the active agent to the surface of interest. A discolored composition (i.e., transparent) in the article indicates that insufficient amounts of liquid are present and that insufficient transfer has occurred.

[0098] The composition can be used to eliminate a variety of pathogens, including microorganisms. In some embodiments, the composition can be used to eliminate pathogens, including but not limited to bacteria, fungi, viruses and parasites.

[0099] The composition can be used to eliminate Gram-positive bacteria (e.g., Vibrio, Salmonella, Shigella, Pseudomonas, Escherichia, Klebsiella, Proteus, Enterobacter, Serratia, Moraxella, Legionella, Bordetella, Gardnerella, Haemophilus, Neisseria, Brucella, Yersinia, Pasteurella, Bacteroids, and Helicobacter). ) and / or Gram-negative bacteria (e.g., Vibrio, Salmonella, Shigella, Pseudomonas, Escherichia, Klebsiella, Proteus, Enterobacter, Serratia, Moraxella, Legionella, Bordetella, Gardnerella, Haemophilus, Neisseria, Brucella, Yersinia, Pasteurella, Bacteroids, and Helicobacter). In some embodiments, the disclosed compositions will achieve at least a 5 log reduction (i.e., a 99.999% reduction) in bacterial species on a surface within 150 seconds, within 120 seconds, within 90 seconds, within 60 seconds, within 45 seconds, within 30 seconds, or within 15 seconds. In certain embodiments, after 30 seconds, the disclosed compositions can achieve at least a 2 log reduction, at least a 3 log reduction, at least a 4 log reduction, at least a 5 log reduction, or at least a 6 log reduction.

[0100] In some embodiments, the compositions can be used to eliminate molds and fungi, such as Candida (e.g., Candida albicans), Aspergillus species, dermatophytes (such as Trichophyton ubrura, Trichophyton mentagrophytes, Microsporum canis, Microsporum gypseux, and Epidermophyton floccosum), Cladosporium, Fusarium, Alternaria, Curvularia, Aspergillus, and Penicillium. In some embodiments, the disclosed compositions will achieve at least a 5 log reduction (i.e., a 99.999% reduction) of fungal species within 150 seconds, within 120 seconds, within 90 seconds, within 60 seconds, within 45 seconds, within 30 seconds, or within 15 seconds. In certain embodiments, after 30 seconds, the disclosed compositions can achieve at least a 2 log reduction, at least a 3 log reduction, at least a 4 log reduction, at least a 5 log reduction, or at least a 6 log reduction.

[0101] In some embodiments, the disclosed compositions can be used to eliminate viruses, including Baculoviridae, Herpesviridae, Iridoviridae, Poxviridae, "African swine fever virus", Adenoviridae, Caulimoviridae, Myoviridae, Phycodnaviridae, Tectiviridae, Papovaviridae, Circoviridae, Parvoviridae, Hepadnaviridae, Cystoviridae, Dikaryotic Viruses, Bimaviridae, Reoviridae, Coronaviridae, Flaviviridae, Togaviridae, "arteritis virus", Astroviridae, Caliciviridae, Picornaviridae, Potyviridae, Retroviridae, Orthomyxoviridae, Filoviridae, Paramyxoviridae, Rhabdoviridae, Arenaviridae and Bunyaviridae. In a preferred embodiment, the composition can be used to eliminate SARS-CoV-2. Other specific viruses that can be eliminated include herpes virus, pox virus, papilloma virus, coronavirus, HIV virus, influenza virus, hepatitis virus, Sendai virus, Sindbis virus and vaccinia virus, West Nile virus and Hanta virus. In some embodiments, the disclosed compositions will achieve at least 3 log reduction (i.e., 99.9% reduction) of viral species within 150 seconds, within 120 seconds, within 90 seconds, within 60 seconds, within 45 seconds, within 30 seconds, or within 15 seconds. In certain embodiments, after 30 seconds, the disclosed compositions can achieve at least 2 log reduction, at least 3 log reduction, at least 4 log reduction, at least 5 log reduction, or at least 6 log reduction.

[0102] The compositions disclosed herein can be applied to a variety of surfaces, including surfaces in kitchens and bathrooms, medical and dental offices, manufacturing facilities, and any other location where pathogen removal is desired. The types of surfaces that the compositions can be used to disinfect and / or sterilize are not limited, including surfaces composed of leather, wood, metal, plastic, synthetic materials, and fabrics.

[0103] The composition can be applied to the surface using any known method. For example, the composition can be applied by spraying, misting, atomizing, exposing to an aerosol, wiping, pouring or soaking.

[0104] Example

[0105] The following examples are for illustration purposes only of the disclosed embodiments and are not intended to limit the scope of the invention in any way.

[0106] The following experiments were performed using 1,1'-dimethyl-4,4'-cyanine iodide as the cyanine dye and were repeated using 1,1'-dibutyl-4,4'-cyanine iodide as the cyanine dye. The results described in Examples 1-11 were the same as those for 1,1'-dimethyl-4,4'-cyanine iodide and 1,1'-dibutyl-4,4'-cyanine iodide. Therefore, the term "cyanine dye" in Examples 1-11 means "1,1'-dimethyl-4,4'-cyanine iodide or 1,1'-dibutyl-4,4'-cyanine iodide".

[0107] Example 1: Prepare an ethanol solution containing 0.06 mg / ml cyanine dye, 0.625 mg / ml citric acid and 5% benzalkonium chloride. The color of the solution is blue.

[0108] Example 2: When the blue solution in Example 1 is spread on a white ceramic substrate or cardboard, the blue color disappears after all the ethanol evaporates.

[0109] Example 3: The blue solution in Example 1 was used to soak a substrate, and the loading of the solution was 300% of the total weight of the substrate (e.g., hydroentangled or hydrowoven material). The soaked substrate showed a blue color. When the substrate was dried in a fume hood, the substrate became colorless.

[0110] Example 4: Use the pre-saturated matrix from Example 3 to wipe a white ceramic plate or cardboard. Some liquid transfers to the surface, forming a thin layer of blue solution. The blue color disappears after about 60 seconds.

[0111] Example 5: Prepare an ethanol solution containing 0.06 mg / ml cyanine dye, 2.5 mg / ml citric acid and 5% benzalkonium chloride. The color of the solution is blue.

[0112] Example 6: The blue solution in Example 5 was used to soak a substrate, and the loading of the solution was 300% of the total weight of the substrate (e.g., hydroentangled or hydrowoven material). The soaked substrate showed a blue color. When the substrate was dried in a fume hood, the substrate became colorless.

[0113] Example 7: Use the pre-saturated matrix from Example 5 to wipe a white ceramic plate or cardboard. Some liquid transfers to the surface, forming a thin layer of blue solution. The blue color disappears after about 30 seconds.

[0114] Example 8: A butanol solution containing 0.06 mg / ml cyanine dye, 0.625 mg / ml citric acid and 5% benzalkonium chloride was prepared. The color of the solution was blue.

[0115] Example 9: The blue solution in Example 8 was used to soak a substrate, and the loading of the solution was 300% of the total weight of the substrate (e.g., hydroentangled or hydrowoven material). The soaked substrate showed a blue color. When the substrate was dried in a fume hood, the substrate became colorless.

[0116] Example 10: Use the pre-saturated matrix from Example 9 to wipe a white ceramic plate or cardboard. Some liquid transfers to the surface, forming a thin layer of blue solution. The blue color disappears after about 120 seconds.

[0117] Example 11: Examples 1 to 10 were repeated, but benzalkonium chloride was replaced by chlorhexidine digluconate, citric acid was replaced by tartaric acid, and ethanol or butanol was replaced by a mixed solvent of ethanol / water or isopropanol / water. The blue color of the solution disappeared when the solution was dried on a substrate or applied to a surface. The color change time would vary depending on the amount and type of acid and the type of solvent.

[0118] Implementation

[0119] In view of the foregoing description and examples, the present disclosure provides the following embodiments.

[0120] Embodiment 1: A composition comprising an active agent, a cyanine dye, an acid, and a solvent, wherein the composition changes color when exposed to standard conditions.

[0121] Embodiment 2: The composition according to embodiment 1, wherein the composition exhibits a maximum absorption value in the region between 400nm-750nm, between 400nm-700nm, between 400nm-600nm, between 400nm-500nm, between 400nm-600nm, between 450nm-550nm, between 450nm-550nm, between 500nm-600nm, between 500nm-700nm, between 550nm-650nm, between 600nm-700nm, or between 650nm-750nm.

[0122] Embodiment 3: A composition according to embodiment 2, wherein when 1 ml of the composition is deposited on a flat surface and exposed for 180 seconds under standard conditions, the maximum absorption value is reduced by at least 80%, at least 85%, at least 90%, at least 95%, at least 97.5% or at least 99%.

[0123] Embodiment 4: A composition according to any preceding embodiment, wherein the solvent comprises an organic solvent having a boiling point (at 1 atm) less than 150°C, less than 140°C, less than 130°C, less than 120°C, less than 110°C, less than 100°C, less than 90°C, less than 80°C, less than 70°C, less than 60°C, or less than 50°C.

[0124] Embodiment 5: The composition according to any preceding embodiment, wherein the solvent comprises an alcohol, a ketone, an ester, water, or a combination thereof.

[0125] Embodiment 6: A composition according to any preceding embodiment, wherein the solvent comprises C 2-6 Alkyl alcohol.

[0126] Embodiment 7: A composition according to any preceding embodiment, wherein the solvent comprises methanol, ethanol, propanol, isopropanol, butanol, sec-butanol, tert-butanol, isobutanol, pentanol, isopentanol, 2-methyl-1-butanol, neopentyl alcohol, 2-pentanol, 3-methyl-2-butanol, 3-pentanol, tert-pentanol, 2-hexanol, 3-hexanol, 2-methyl-1-pentanol, 3-methyl-1-pentanol, 4-methyl-1-pentanol, 2-methyl-2-pentanol, 3-methyl-2-pentanol, 4-methyl-2-pentanol, 2-methyl-3-pentanol, 3-methyl-3-pentanol, 2,2-dimethyl-1-butanol, 2,3-dimethyl-1-butanol, 3,3-dimethyl-1-butanol, pentanol, hexanol, octanol, or a combination thereof.

[0127] Embodiment 8: The composition of any preceding Embodiment, wherein the solvent has a boiling point (at 1 atm) less than 120°C.

[0128] Embodiment 9: The composition according to any preceding embodiment, wherein the solvent comprises ethanol, butanol, n-propanol, isopropanol, n-butanol, isobutanol, or a combination thereof.

[0129] Embodiment 10: A composition according to any preceding embodiment, wherein the solvent comprises water in an amount (v / v) of 5%-95%, 5%-50%, 5%-25%, 5%-15%, 5%-10%, 10%-20%, 15%-30%, 25%-50%, 40%-60%, 25%-75%, 50%-75%, 50%-95%, 75%-95%, 80%-95% or 90%-95%.

[0130] Embodiment 11: A composition according to any preceding embodiment, wherein the solvent comprises water in an amount (v / v) of 0%-5%, 0%-2.5%, 0%-1.5%, 0%-1%, 0%-0.5%, 0%-0.25% or 0%-0.1%.

[0131] Embodiment 12: The composition according to any preceding embodiment, wherein the active agent comprises an antibacterial agent, an antiviral agent, an antifungal agent, an antiparasitic agent, or a combination thereof.

[0132] Embodiment 13: A composition according to any of the preceding embodiments, wherein the active agent is present in an amount of 0.01%-25% by weight, 0.01%-5% by weight, 0.1%-5% by weight, 0.1%-2.5% by weight, 0.5%-5% by weight, 1%-2.5% by weight, 1%-5% by weight, 2.5%-7.5% by weight, 2.5%-10% by weight, 5%-15% by weight, 5%-10% by weight, 10%-15% by weight, 10%-20% by weight, 10%-25% by weight, or 15%-25% by weight.

[0133] Embodiment 14: A composition according to any preceding embodiment, wherein the composition comprises a quaternary ammonium compound.

[0134] Embodiment 15: A composition according to any preceding embodiment, wherein the composition comprises a quaternary ammonium compound having the formula:

[0135]

[0136] Where R q1 , R q2 , R q3 and R q4 Independently selected from C1-20 Alkyl, C 0-4 Alkyl and C 0-4 Alkylheteroaryl, where R q1 , R q2 , R q3 and R q4 Any two or more of may form a ring together with the nitrogen atom, and X q is an acceptable anion.

[0137] Embodiment 16: A composition according to embodiment 15, wherein R q2 , R q3 and R q4 Each independently selected from C 1-4 Alkyl, and R q1 It is C 6-20 Alkyl or C 0-4 Alkyl.

[0138] Embodiment 17: A composition according to any one of embodiments 15 to 16, wherein R q3 and R q4 Each is a methyl group, R q2 It is C 4-10 Alkyl, and R q1 It is C 7-20 Alkyl or C 0-4 Alkyl

[0139] Embodiment 18: A composition according to any one of embodiments 14 to 17, wherein the quaternary ammonium compound comprises alkyl dimethyl benzyl ammonium chloride, alkyl dimethyl ethyl benzyl ammonium chloride, octyl decyl dimethyl ammonium chloride, dioctyl dimethyl ammonium chloride, didecyl dimethyl ammonium chloride, benzethonium chloride, ethyl benzyl alkyl ammonium chloride, ethyl benzethonium chloride, myristyl trimethyl ammonium chloride, methyl benzethonium chloride, cetaxonium chloride, cetrimonium bromide (CTAB), carnitine, dequalinium chloride, dofadum chloride, tetraethylammonium bromide (TEAB), domiphene bromide, octenidine dihydrochloride, cilamide, benzododecyl ammonium bromide, benzozonium chloride, choline and denatonium.

[0140] Embodiment 19: A composition according to any preceding embodiment, wherein the composition comprises a quaternary ammonium compound in an amount of 0.01 wt%-5 wt%, 0.1 wt%-5 wt%, 0.1 wt%-2.5 wt%, 0.5 wt%-5 wt%, 1 wt%-2.5 wt%, 1 wt%-5 wt%, 2.5 wt%-7.5 wt%, 2.5 wt%-10 wt%, 5 wt%-15 wt%, 5 wt%-10 wt%, 10 wt%-15 wt%, 10 wt%-20 wt%, 10 wt%-25 wt%, or 15 wt%-25 wt%.

[0141] Embodiment 20: The composition according to any preceding Embodiment, wherein the composition comprises a biguanide compound.

[0142] Embodiment 21: The composition according to embodiment 20, wherein the biguanide comprises ethylene biguanide, propylene biguanide, tetramethylene biguanide, pentamethylene biguanide, hexamethylene biguanide, heptamethylene biguanide, octamethylene biguanide, 1,6-bis-(4-chlorobenzyl biguanide)-hexane 1,1′-hexamethylenebis(5-(p-chlorophenyl)biguanide)(chlorhexidine), 2-(benzyloxymethyl)pentane-1,5-bis(5-hexylbiguanide), 2-(phenylthiomethyl)pentane-1,5-bis(5-phenylethylbiguanide), 3-(phenylthio)hexane-1,6-bis(5-hexylbiguanide), 3-(phenylthio)hexane-1,6-bis(5-cyclohexylbiguanide), 3-(benzylthio)hexane-1,6-bis(5-hexylbiguanide) and 3- (Benzylthio) hexane-1,6-bis(5-cyclohexylbiguanide), phenylbiguanide, naphthylbiguanide, pyridylbiguanide, piperazinylbiguanide, phthaloylbiguanide, 1,1′-[4-(dodecyloxy)-m-phenylene]biguanide, 2-(decylthiomethyl)pentane-1,5-bis(5-isopropylbiguanide), 2-(decylthiomethyl)pentane-1,5-bis(5,5-diethylbiguanide), Alexidine, salts thereof, or combinations thereof.

[0143] Embodiment 22: A composition according to any of the preceding embodiments, wherein the composition comprises a biguanide compound in an amount of 0.01 wt%-5 wt%, 0.1 wt%-5 wt%, 0.1 wt%-2.5 wt%, 0.5 wt%-5 wt%, 1 wt%-2.5 wt%, 1 wt%-5 wt%, 2.5 wt%-7.5 wt%, 2.5 wt%-10 wt%, 5 wt%-15 wt%, 5 wt%-10 wt%, 10 wt%-15 wt%, 10 wt%-20 wt%, 10 wt%-25 wt%, or 15 wt%-25 wt%.

[0144] Embodiment 23: A composition according to any preceding embodiment, wherein the composition comprises a surfactant.

[0145] Embodiment 24: A composition according to any of the preceding embodiments, wherein the composition comprises a surfactant in an amount of 0.01 wt%-5 wt%, 0.1 wt%-5 wt%, 0.1 wt%-2.5 wt%, 0.5 wt%-5 wt%, 1 wt%-2.5 wt%, 1 wt%-5 wt%, 2.5 wt%-7.5 wt%, 2.5 wt%-10 wt%, 5 wt%-15 wt%, 5 wt%-10 wt%, 10 wt%-15 wt%, 10 wt%-20 wt%, 10 wt%-25 wt%, or 15 wt%-25 wt%.

[0146] Embodiment 25: The composition according to any preceding embodiment, wherein the composition comprises an anionic surfactant, a cationic surfactant, a nonionic surfactant, or a combination thereof.

[0147] Embodiment 26: The composition according to any preceding embodiment, wherein the composition comprises a sulfonate surfactant, a carboxylate surfactant, a sulfate surfactant, or a combination thereof.

[0148] Embodiment 27: A composition according to any preceding embodiment, wherein the composition comprises sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, sodium laurate, sodium lauryl sulfate, sodium lauryl sarcosinate, potassium lauryl sulfate, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylene sulfonate, magnesium lauryl sulfate, sodium myristyl sulfate, sodium nonanoyloxybenzene sulfonate, ammonium xylene sulfonate, or a combination thereof.

[0149] Embodiment 28: A composition according to any preceding embodiment, wherein the composition comprises an anionic surfactant.

[0150] Embodiment 29: A composition according to any preceding embodiment, wherein the composition comprises a nonionic surfactant.

[0151] Embodiment 30: A composition according to any preceding embodiment, wherein the composition comprises betaines such as cocamidopropyl betaine, sultaines such as cocamidopropyl hydroxysultaine and lauramidopropyl hydroxysultaine, amphoacetates and amphodiacetates such as disodium lauroamphodiacetate, disodium cocoamphodiacetate, sodium lauroamphoacetate, sodium cocoamphoacetate, disodium cocoamphodipropionate, disodium lauroamphodipropionate, or a combination thereof.

[0152] Embodiment 31: The composition according to any preceding embodiment, wherein the composition comprises at least one anionic surfactant and at least one nonionic surfactant.

[0153] Embodiment 32: A composition according to any preceding embodiment, wherein the composition comprises a concentration of 0.05 mg / ml-50 mg / ml, 10 mg / ml-50 mg / ml, 25 mg / ml-50 mg / ml, 10 mg / ml-25 mg / ml, 0.05 mg / ml-25 mg / ml, 0.05 mg / ml-10 mg / ml, 0.1 mg / ml-10 mg / ml, 0.5 mg / ml-10 mg / ml, 1 mg / ml-10mg / ml, 2mg / ml-10mg / ml, 4mg / ml-10mg / ml, 5mg / ml-10mg / ml, 7.5mg / ml-10mg / ml, 0.05mg / ml-2.5mg / ml, 0.1mg / ml-2.5mg / ml, 0.5mg / ml-2.5mg / ml, 1mg / ml-2.5mg / ml, 1mg / ml-5mg / ml or 2.5mg / ml-5mg / ml of acid.

[0154] Embodiment 33: The composition of any preceding Embodiment, wherein the acid comprises a polyacid.

[0155] Embodiment 34: The composition of any preceding Embodiment, wherein the acid comprises a polyacid having two or three acidic groups.

[0156] Embodiment 35: A composition according to any preceding embodiment, wherein the composition comprises an acid having a boiling point (at 1 atm) of at least 100°C, at least 125°C, at least 150°C, at least 200°C, at least 250°C, at least 300°C, at least 350°C, or at least 400°C.

[0157] Embodiment 36: A composition according to any preceding embodiment, wherein the composition comprises an acid having a melting point of at least 75°C, at least 100°C, at least 125°C, at least 150°C, at least 175°C, at least 200°C, at least 250°C, or at least 300°C.

[0158] Embodiment 37: A composition according to any preceding embodiment, wherein the composition comprises an acid having a pKa of 0-6.5, 1-6.5, 2-6.5, 3-6.5, 4-6.5, 5-6.5, 1-3, 2-4 or 3-5 (measured in water at 23°C).

[0159] Embodiment 38: The composition of any preceding Embodiment, wherein the composition comprises a compound having a single acidic group, two acidic groups, three acidic groups, or more than three acidic groups.

[0160] Embodiment 39: A composition according to any preceding embodiment, wherein the composition comprises acetic acid, adipic acid, phthalic acid, benzoic acid, butyric acid, citric acid, toluic acid, capric acid, caproic acid, cyanuric acid, dihydroacetic acid, 2-ethyl-hexanoic acid, formic acid, fumaric acid, gluconic acid, glycolic acid, 1-glutamic acid, lactic acid, maleic acid, malic acid, methanesulfonic acid, cyclohexane acid, oxalic acid, phytic acid, polyacrylic acid, propionic acid, salicylic acid, sorbic acid, tartaric acid, valeric acid, or a combination thereof.

[0161] Embodiment 40: The composition according to any preceding embodiment, wherein the composition comprises citric acid, tartaric acid, fumaric acid, malic acid, maleic acid, or a combination thereof.

[0162] Embodiment 41: The composition of any preceding embodiment, wherein the cyanine dye comprises catenella cyanine, hemicyanine, cleoscyanine, merocyanine, apocyanine, or a combination thereof.

[0163] Embodiment 42: The composition of any preceding embodiment, wherein the cyanine dye comprises quinocyanine, isoquinocyanine, mixed quinocyanine / isoquinocyanine, indolium cyanine, or a combination thereof.

[0164] Embodiment 43: A composition according to any preceding embodiment, wherein the composition comprises the acid and the cyanine dye in a weight ratio of 1:1 to 500:1, 1:1 to 250:1, 1:1 to 100:1, 1:1 to 75:1, 1:1 to 50:1, 1:1 to 40:1, 1:1 to 30:1, 1:1 to 20:1, 1:1 to 10:1, 5:1 to 50:1, 10:1 to 25:1, 10:1 to 50:1, 20:1 to 50:1, 25:1 to 50:1, 25:1 to 75:1, 50:1 to 100:1, 50:1 to 150:1, or 100:1 to 500:1.

[0165] Embodiment 44: An article comprising: a substrate, and a composition according to any preceding embodiment absorbed onto the substrate.

[0166] Embodiment 45: An article according to Embodiment 44, wherein the matrix comprises the composition in an amount of at least 100 weight percent, at least 150 weight percent, at least 200 weight percent, at least 300 weight percent, at least 400 weight percent, at least 500 weight percent, at least 600 weight percent, at least 700 weight percent, at least 800 weight percent, at least 900 weight percent, or at least 1,000 weight percent relative to the dry weight of the matrix.

[0167] Embodiment 46: An article according to any of Embodiments 44 to 45, wherein the substrate comprises the composition in an amount of 50 wt%-1,000 wt%, 100 wt%-1,000 wt%, 200 wt%-1,000 wt%, 100 wt%-1,000 wt%, 200 wt%-1,000 wt%, 100 wt%-1,000 wt%, 200 wt%-1,000 wt%, 300 wt%-1,000 wt%, 400 wt%-1,000 wt%, 500 wt%-1,000 wt%, 600 wt%-1,000 wt%, 750 wt%-1,000 wt%, 100 wt%-500 wt%, or 250 wt%-750 wt%, relative to the dry weight of the substrate.

[0168] Embodiment 47: The article of any one of Embodiments 44 to 46, wherein the article is a wipe, cloth, or sponge.

[0169] Embodiment 48: A method of disinfecting a surface, the method comprising: applying a composition according to any preceding embodiment to the surface, wherein the composition disinfects the surface by eliminating pathogens on the surface.

[0170] Embodiment 49: The method of Embodiment 48, wherein the sterilization comprises at least a 3 log reduction of the pathogen.

[0171] Embodiment 50: The method of Embodiment 49, wherein the pathogen comprises bacteria, fungi, viruses, parasites, or a combination thereof.

[0172] Embodiment 51: The method of any one of Embodiments 49 to 50, wherein the pathogen comprises a Gram-negative bacterium, a Gram-positive bacterium, or a combination thereof.

[0173] Embodiment 52: The method of any one of Embodiments 49 to 51, wherein the sterilization provides a 5 log reduction or more of the pathogen.

[0174] Embodiment 53: The method of any one of Embodiments 48 to 52, comprising removing residual composition from the surface after the composition changes color.

[0175] The scope of the compositions and methods of the appended claims is not limited by the specific compositions and methods described herein, which are intended to illustrate several aspects of the claims, and any compositions and methods that are functionally equivalent are intended to fall within the scope of the claims. In addition to the compositions and methods shown and described herein, various modifications of the compositions and methods are intended to fall within the scope of the appended claims. In addition, although only certain representative compositions and method steps disclosed herein are specifically described, other combinations of composition and method steps are intended to fall within the scope of the appended claims even if they are not specifically described. Therefore, the present invention may explicitly or less refer to a combination of steps, elements, components or ingredients, however, even if not explicitly stated, other combinations of steps, elements, components and ingredients are also included. As used herein, the term "including" and its variants are used synonymously with the term "comprising" and its variants, and are open, non-restrictive terms. Although the terms "including" and "comprising" have been used herein to describe various embodiments, the terms "consisting essentially of" and "consisting of" can be used instead of "including" and "comprising" to provide more specific embodiments of the present invention, and are also disclosed. Except in the examples or otherwise indicated, all numbers used in the specification and claims to indicate quantities of ingredients, reaction conditions, etc. should be interpreted at least in terms of the number of significant digits and ordinary approximations, and no attempt is made to limit the application of the doctrine of equivalents to the scope of the claims.

Claims

1. A composition comprising an active agent, a cyanine dye, an acid, and a solvent, wherein the composition changes color when exposed to standard conditions.

2. The composition according to claim 1, wherein the composition exhibits a maximum absorption value in the region between 400 nm and 750 nm.

3. The composition of claim 2, wherein during the color change, the maximum absorption value of the composition decreases by at least 80% when 1 ml of the composition is deposited on a flat surface and exposed for 180 seconds under standard conditions.

4. The composition of claim 1, wherein the solvent comprises an organic solvent having a boiling point (at 1 atm) less than 120°C.

5. The composition of claim 1, wherein the solvent comprises an alcohol, a ketone, an ester, water, or a combination thereof.

6. The composition according to claim 1, wherein the solvent comprises C 2-6 Alkyl alcohol.

7. The composition of claim 1, wherein the active agent comprises an antibacterial agent, an antiviral agent, an antifungal agent, an antiparasitic agent, or a combination thereof.

8. The composition of claim 1, wherein the active agent comprises a quaternary ammonium compound, a biguanide compound, or a combination thereof.

9. The composition according to claim 8, wherein the composition comprises the quaternary ammonium compound, the biguanide compound or a combination thereof in an amount of 0.01 wt% to 25 wt%.

10. The composition of claim 1, wherein the active agent comprises an anionic surfactant, a cationic surfactant, a nonionic surfactant, or a combination thereof.

11. The composition according to claim 10, wherein the composition comprises 0.01 wt% to 25 wt% of a surfactant.

12. The composition of claim 1, wherein the acid comprises a polyacid having two or three acidic groups.

13. The composition of claim 12, wherein the composition comprises citric acid, tartaric acid, fumaric acid, malic acid, maleic acid, or a combination thereof.

14. The composition of claim 1, wherein the acid has a boiling point (at 1 atm) less than 200°C.

15. The composition of claim 1, wherein the cyanine dye comprises catenella cyanine, hemicyanine, cleoscyanine, merocyanine, apocyanine, or a combination thereof.

16. The composition of claim 15, wherein the cyanine dye comprises a closed-chain cyanine.

17. The composition of claim 1, wherein the composition comprises the acid and the cyanine dye in a weight ratio of 1:1 to 500:

1.

18. The composition of claim 1, wherein the cyanine dye is 1,1'-dimethyl-4,4'-cyanine iodide or 1,1'-dibutyl-4,4'-cyanine iodide.

19. The composition of claim 1, wherein the cyanine dye is 1,1'-dimethyl-4,4'-cyanine iodide or 1,1'-dibutyl-4,4'-cyanine iodide; wherein the acid is citric acid; wherein the active agent is benzalkonium chloride; and wherein the solvent is ethanol.

20. The composition of claim 1, wherein the cyanine dye is 1,1'-dimethyl-4,4'-cyanine iodide or 1,1'-dibutyl-4,4'-cyanine iodide; wherein the acid is tartaric acid; wherein the active agent is chlorhexidine gluconate; and wherein the solvent is butanol.

21. An article, comprising: A matrix, and the composition according to claim 1 loaded on the matrix.

22. The article of claim 21, wherein the substrate comprises the composition in an amount of at least 100% by weight relative to the dry weight of the substrate.

23. A method for sterilizing a surface, the method comprising: The composition of claim 1 is applied to the surface, wherein the composition disinfects the surface by eliminating pathogens on the surface.

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