Rye pollen composition and functional food and use thereof in preventing and / or improving prostate dysfunction

Abstract

The present invention provides a composition of rye pollen and a functional food and use thereof in preventing and / or improving prostate dysfunction, and relates to the technical field of functional foods. The composition provided by the present invention comprises rye pollen, emblica powder and grape and apple compound fruit powder. The combination is simple and convenient, does not require the addition of excessive ingredients, and is easy and convenient to use. The composition prepared by the present invention improves urinary function, and normalization of prostate function also helps to enhance and improve male sexual function, so as to achieve two-way improvement of urinary function and sexual function.

Description

Technical Field

[0001] The invention relates to the technical field of functional foods, and in particular to a rye pollen composition and functional food and application thereof in preventing and / or improving prostate dysfunction. Background Art

[0002] The prostate is a glandular organ in the male reproductive system. It surrounds the beginning of the urethra and two ejaculatory ducts pass through it. The prostate is cone-shaped and located between the inner edges of the two levator ani muscles. With the increasing aging of the population, the incidence of benign prostatic hyperplasia (BPH) and chronic prostatitis (CP) is increasing year by year. The lower urinary tract symptoms caused by BPH seriously affect the quality of life of middle-aged and elderly patients, and the age of patients is also tending to be younger.

[0003] A large number of social surveys and medical statistics at home and abroad show that more and more diseases are rapidly approaching men, and are constantly and seriously threatening the physical and mental health of male comrades. The prominent health problem currently faced by men is urinary health, and the common problems of the male urinary system are mainly caused by prostate dysfunction. With the increase of age, the level of male hormones in individuals decreases, and the male prostate has two common problems: prostatitis and prostate hyperplasia. Prostate diseases are closely related to age and hormone levels in men. Prostatitis is more common in young and middle-aged people; while prostate hyperplasia and prostate cancer are more common in middle-aged and elderly people over 50 years old. Prostate diseases often have the characteristics of long course of disease, prolonged and difficult to cure, and easy recurrence. There is a lack of efficient treatment methods, poor treatment effect, and low cure rate. At the same time, the male prostate is an important accessory gland of men. It can control men's urination function and erectile function, and has a very close relationship with men's reproductive health and urinary health.

[0004] Male urinary dysfunction is mainly treated with 5-α reductase inhibitors such as finasteride. These drugs are slow to take effect and require PSA screening before use, which is a cumbersome process. There are many solutions for male reproductive function, but existing solutions often ignore the impact of the male prostate on male reproductive function. There are few comprehensive products that can improve male reproductive function by normalizing male urinary function.

[0005] At present, the main treatments for male urinary system dysfunction are pharmaceuticals or medical device products, while relatively few are using food solutions to solve such problems.

[0006] Chinese patent CN 102077944 A provides a special marine food for prostate patients, which mainly uses marine oligopeptides, marine bioactive polysaccharides, seaweed powder, nutritional amino acids, oligopeptides, nutrients and other ingredients to supplement the nutritional components of prostate patients, supplement the colloid of the spongy body, and promote the health of the prostate; however, the food mainly focuses on relieving the discomfort caused by prostate problems from a nutritional perspective, and has no effect on existing inflammation or hyperplasia.

[0007] Chinese patent CN 117064996 A provides a composition for protecting the prostate and a preparation method thereof, which uses bee pollen as the main raw material and prepares capsule products for protecting the prostate through wall breaking and fermentation processes. From the content of the patent, it can be seen that the process of fermenting rapeseed flowers is complicated, and it is difficult to obtain standardized products and it is difficult to guarantee the effectiveness of the products.

[0008] Rye pollen is prepared by pollen collection, drying, separation and other processes of rye (Secale Cereale L.) of the Gramineae family, and contains functional ingredients such as phytosterols and a variety of water-soluble amino acids. The prior art already has the application of rye pollen in the treatment of prostate diseases, such as Chinese patent CN118749657A discloses a food composition that helps to relieve prostatitis and prevent prostate hyperplasia. The food composition includes the following raw material components: yam powder, adzuki bean powder, tomato powder, rye pollen, Euryale powder, Poria powder, dandelion powder, Platycodon powder, licorice powder, Cistanche powder, Eucommia leaf powder, Gardenia powder, turmeric powder, oyster peptide, edible yeast powder. The food composition of the invention is mainly composed of safe and edible raw materials of medicinal and edible origin, such as yam, red bean, Euryale ferox, Poria, dandelion, Platycodon grandiflorum, licorice, Eucommia ulmoides leaf, Gardenia jasminoides, and Cistanche deserticola, combined with the protective and anti-inflammatory effects of tomato, rye pollen, and turmeric, and edible yeast powder and oyster peptide to supplement the protein, organic zinc and other mineral elements required by prostatitis patients. Through multi-party coordination and scientific proportioning, it significantly improves its efficacy in relieving prostatitis and preventing prostatic hyperplasia. However, its components are too complicated and the side effects are unknown.

[0009] In summary, developing a composition with a simple formula, easy to use, which can not only relieve the discomfort caused by prostate diseases, but also effectively treat prostate inflammation, hyperplasia, etc. is the research direction of researchers in this field. Summary of the invention

[0010] In view of the above problems, the present invention provides a rye pollen composition comprising rye pollen, emblica powder and grape and apple composite fruit powder.

[0011] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0012] In one aspect, the present invention provides a rye pollen composition comprising rye pollen, emblica powder and grape and apple compound fruit powder.

[0013] Preferably, the mass ratio of the rye pollen, the emblica powder and the grape and apple composite fruit powder is 0.1-1:0.05-0.5:0.01-0.2.

[0014] Further preferably, the mass ratio of the rye pollen, the emblica powder and the grape and apple composite fruit powder is 0.1-0.5:0.05-0.3:0.05-0.2.

[0015] More preferably, the mass ratio of the rye pollen, the emblica powder and the grape and apple composite fruit powder is 0.25:0.1:0.1.

[0016] Preferably, the rye pollen is taken from rye as the base plant and is prepared through pollen harvesting, drying and separation.

[0017] Preferably, the phytosterol content of the rye pollen is ≥ 0.1%.

[0018] Preferably, the content of small molecule hydrolyzed tannic acid in the emblica powder is ≥ 60.0%.

[0019] In yet another aspect, the present invention provides a functional food comprising the above composition.

[0020] Preferably, the functional food further comprises functional ingredients that are helpful for male urinary function or sexual function.

[0021] Further preferably, the functional ingredients include at least one of yeast powder containing B vitamins, yeast powder containing zinc, curcumin, broccoli extract, lycopene microcapsule powder, pumpkin seed powder, phytosterol ester powder, sophora japonica rice powder, maca powder, polygonatum powder, saffron extract, oyster peptide powder and pyrroloquinoline quinone disodium salt (PQQ).

[0022] Preferably, the functional food further comprises a food-acceptable auxiliary material.

[0023] Preferably, the dosage form of the functional food is at least one of tablets, solid beverages, and hard capsules.

[0024] Further preferably, the auxiliary material is selected from at least one of functional raw materials, flavoring agents, colorants, preservatives, nutritional enhancers and excipients.

[0025] In yet another aspect, the present invention provides use of the above-mentioned composition or functional food in preventing and / or improving prostate dysfunction.

[0026] Compared with the prior art, the present invention has the following beneficial effects:

[0027] 1. The specific combination of rye pollen, emblica powder and grape and apple composite fruit powder and the composition prepared by the specific ratio thereof are simple and convenient to combine, do not need to add too many additional ingredients, and are easy and convenient to use.

[0028] 2. The composition provided by the present invention comprises rye pollen which can help men's prostate health, especially urination disorders caused by prostatitis and prostatic hyperplasia in men, and improve men's quality of life; the strong antioxidant capacity of emblica powder and grape-apple compound fruit powder can remove free radicals in men's bodies, prevent and improve inflammation problems; in addition, the grape-apple compound fruit powder can promote the activation of endothelial nitric oxide synthase in vascular endothelial cells and increase the release of nitric oxide, which is an important biological regulator, promotes vasodilation, increases blood circulation, avoids long-term congestion of prostate tissue, and also helps the blood circulation of male penile corpus cavernosum tissue.

[0029] 3. The composition prepared by the present invention improves urinary function and normalizes prostate function, which also helps to enhance and improve male sexual function, thereby achieving two-way improvement of urinary function and sexual function. DETAILED DESCRIPTION

[0030] In order to make the technical means, creative features, purpose and effect of the present invention easy to understand, the present invention is further explained below in conjunction with specific embodiments, but the following embodiments are only preferred embodiments of the present invention, not all. Based on the embodiments in the implementation mode, other embodiments obtained by those skilled in the art without making creative work all belong to the protection scope of the present invention. It is worth noting that the raw materials used in the present invention are all common commercial products, and their sources are not specifically limited. The technology and scientific terms used in the embodiments have the meanings commonly understood by those of ordinary skill in the art to which the present invention belongs.

[0031] The main raw materials used in the present invention, namely rye pollen, emblica powder and grape and apple compound fruit powder, are all from Guangzhou Nengliang Biotechnology Co., Ltd.

[0032] Example 1

[0033] A functional food, comprising a composition of rye pollen, is prepared by the following method:

[0034] Rye pollen, emblica powder and grape and apple compound fruit powder were mixed, and microcrystalline cellulose, sorbitol and magnesium stearate were added to the mixture. After mixing evenly, a multi-punch tablet press was used for tableting. After selecting qualified tablets, they were sent to the inner packaging workshop for packaging and inspection and storage. The raw material ratio is shown in Table 1.

[0035] Example 2

[0036] A functional food, comprising a composition of rye pollen, is prepared by the following method:

[0037] Rye pollen, amla powder and grape and apple compound fruit powder are mixed, and microcrystalline cellulose, sorbitol and magnesium stearate are added. After mixing evenly, tablets are pressed using a multi-punch tablet press. After selecting qualified tablets, they are sent to the inner packaging workshop for packaging and inspection and storage.

[0038] The raw material ratio is shown in Table 1.

[0039] Example 3

[0040] A functional food, comprising a composition of rye pollen, is prepared by the following method:

[0041] Rye pollen, amla powder and grape and apple compound fruit powder are mixed, and microcrystalline cellulose, sorbitol and magnesium stearate are added. After mixing evenly, tablets are pressed using a multi-punch tablet press. After selecting qualified tablets, they are sent to the inner packaging workshop for packaging and inspection and storage.

[0042] The raw material ratio is shown in Table 1.

[0043] Comparative Example 1

[0044] A functional food, comprising a composition of rye pollen, is prepared by the following method:

[0045] Rye pollen, microcrystalline cellulose, sorbitol and magnesium stearate are mixed evenly and then tableted using a multi-punch tablet press. Qualified tablets are selected and sent to the inner packaging workshop for packaging and inspection and storage. The raw material ratio is shown in Table 1.

[0046] Comparative Example 2

[0047] A functional food, comprising a composition of rye pollen, is prepared by the following method:

[0048] After the amla powder, microcrystalline cellulose, sorbitol and magnesium stearate are evenly mixed, they are compressed into tablets using a multi-punch tablet press. After the qualified tablets are selected, they are sent to the inner packaging workshop for packaging and inspection and storage.

[0049] The raw material ratio is shown in Table 1.

[0050] Comparative Example 3

[0051] A functional food, comprising a composition of rye pollen, is prepared by the following method:

[0052] After the grape and apple compound fruit powder, microcrystalline cellulose, sorbitol and magnesium stearate are evenly mixed, they are pressed into tablets using a multi-punch tablet press. After the qualified tablets are selected, they are sent to the inner packaging workshop for packaging and inspection and storage.

[0053] The raw material ratio is shown in Table 1.

[0054] Comparative Example 4

[0055] A functional food, comprising a composition of rye pollen, is prepared by the following method:

[0056] Rye pollen, grape and apple compound fruit powder, microcrystalline cellulose, sorbitol and magnesium stearate are mixed evenly and then compressed into tablets using a multi-punch tablet press. Qualified tablets are selected and packaged in the inner packaging workshop and inspected and put into storage.

[0057] The raw material ratio is shown in Table 1.

[0058] Comparative Example 5

[0059] A functional food, comprising a composition of rye pollen, is prepared by the following method:

[0060] Rye pollen, emblica powder, microcrystalline cellulose, sorbitol and magnesium stearate are mixed evenly and then compressed into tablets using a multi-punch tablet press. Qualified tablets are selected and packaged in the inner packaging workshop and inspected and put into storage.

[0061] The raw material ratio is shown in Table 1.

[0062] Comparative Example 6

[0063] A functional food, comprising a composition of rye pollen, is prepared by the following method:

[0064] After the amla powder, grape and apple compound fruit powder, microcrystalline cellulose, sorbitol and magnesium stearate are evenly mixed, they are pressed into tablets using a multi-punch tablet press. After the qualified tablets are selected, they are sent to the inner packaging workshop for packaging and inspection and storage.

[0065] The raw material ratio is shown in Table 1.

[0066] Table 1. Raw material ratios of Examples 1-3 and Comparative Examples 1-6

[0067]

[0068] Test Example 1

[0069] Prostate function assessment:

[0070] The most widely used chronic prostatitis symptom scoring system is the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI), which is shown in Table 2. The NIH-CPSI consists of three parts, which respectively evaluate the pain or discomfort caused by chronic prostatitis, urination symptoms, and the impact on quality of life, with a total of 9 questions.

[0071] Table 2. Chronic Prostatitis Symptom Index (NIH-CPSI)

[0072]

[0073]

[0074]

[0075] Note: 1. The severity of the condition (the sum of the total scores of questions 1-6) is divided into mild (0-9 points), moderate (10-18 points), and severe (19-31 points). 2. The total score (the sum of the total scores of questions 1-9) is 0-43 points, which can be used for self-control of each patient before and after treatment.

[0076] 54 males with an average age of 45.2±4.3 years old suffering from chronic prostatitis (persistent symptoms for more than 12 months) were randomly divided into 9 groups, each group consisting of 6 male patients, and took the tablet samples (0.8 g / tablet) prepared by Examples 1-3 and Comparative Examples 1-6, 3 tablets per day, for 30 days; each subject was given NIH-CPSI score before the test, and another NIH-CPSI score was performed after 30 days to compare the evaluation scores before and after taking.

[0077] The results of the prostate function test evaluation are shown in Table 3.

[0078] Table 3. Prostate function test evaluation results

[0079] Group NIH-CPSI score (before the test) NIH-CPSI score (after 30 days of trial) Example 1 27..3±2.3 10.3±2.5** Example 2 24.1±1.5 17.4±1.7* Example 3 26.3±1.7 18.7±1.2* Comparative Example 1 25.8±2.4 20.3±1.8 Comparative Example 2 24.3±1.2 23.3±2.4 Comparative Example 3 27.2±1.8 25.8±1.2 Comparative Example 4 25.1±1.8 20.1±2.3 Comparative Example 5 26.4±1.7 24.2±1.6 Comparative Example 6 26.2±2.1 25.4±1.7

[0080] Note: p<0.01 indicates extremely significant, indicated by **, p<0.05 indicates significant, indicated by *;

[0081] It can be seen from the data in Table 3 that the functional foods prepared in Examples 1-3 are helpful to alleviate and improve the urination dysfunction caused by chronic prostatitis and prostatic hyperplasia in middle-aged and elderly men, and at the same time help to improve the daily quality of life of male patients; from the test evaluation results of Examples 1-3, it can be seen that rye pollen, emblica powder, and grape and apple compound fruit powder have a synergistic effect on the normalization of male prostate function.

[0082] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. A composition of rye pollen, characterized in that: Contains rye pollen, amla powder and grape-apple complex fruit powder.

2. The composition according to claim 1, characterized in that The mass ratio of the rye pollen, the emblica powder and the grape and apple composite fruit powder is 0.1-1:0.05-0.5:0.01-0.

2.

3. The composition according to claim 1, characterized in that The mass ratio of the rye pollen, the emblica powder and the grape and apple composite fruit powder is 0.1-0.5:0.05-0.3:0.05-0.

2.

4. The composition according to claim 1, characterized in that The rye pollen is made from rye as a base plant through pollen collection, drying and separation.

5. The composition according to claim 1, characterized in that The content of phytosterol in the rye pollen is ≥0.1%, and the content of small molecule hydrolyzed tannic acid in the emblica powder is ≥60.0%.

6. A functional food, characterized in that: A composition comprising any one of claims 1 to 5.

7. The functional food according to claim 6, characterized in that The food further comprises functional ingredients that are helpful for male urinary function or sexual function.

8. The functional food according to claim 7, characterized in that The functional ingredients include common functional ingredients, and at least one of yeast powder containing B vitamins, yeast powder containing zinc, curcumin, broccoli extract, lycopene microcapsule powder, phytosterol ester powder, pumpkin seed powder, sophora japonica rice powder, maca powder, polygonatum powder, saffron extract, oyster peptide powder and disodium pyrroloquinoline quinone.

9. The functional food according to claim 6, characterized in that The functional food further comprises food-acceptable auxiliary materials; the dosage form of the functional food is at least one of tablets, solid beverages, and hard capsules; the auxiliary materials are selected from at least one of functional raw materials, flavoring agents, colorants, preservatives, nutritional enhancers, and excipients.

10. Use of the composition according to any one of claims 1 to 5 or the functional food according to any one of claims 6 to 9 in preventing and / or improving prostate dysfunction.

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