Scalp brain signal acquisition method, system, medium and electronic equipment

Abstract

The present application provides a scalp brain signal acquisition method, system, medium, and electronic device, relating to the field of brain-computer interface technology. The scalp brain signal acquisition method includes: determining FUS excitation signal parameters based on head acoustic parameters; the excitation signal parameters are used to position the irradiation focus of the focused ultrasound FUS of the ultrasonic phased-control transducer on the scalp contour; responding to ultrasonic stimulation instructions, based on the excitation signal parameters, controlling the ultrasonic phased-control transducer to generate array element excitation signals to ultrasonically irradiate the irradiation focus; and responding to EEG acquisition instructions, acquiring EEG signals to obtain focused ultrasound-modulated scalp EEG signals. This method can improve the accuracy of scalp EEG signals.

Description

Technical Field

[0001] The present application relates to the field of brain-computer interface technology, and in particular to a scalp brain signal acquisition method, system, medium and electronic equipment. Background Art

[0002] Electroencephalogram (EEG) is a technology that noninvasively records electrical activity in the brain and is currently being applied to research in cognitive science, cognitive psychology, neurolinguistics, and other brain sciences. Electrode caps are generally used in clinical testing and trials to accurately and quickly determine electrode placement and collect brain signals. Commercial electrode caps often use a 10-20 lead placement system, based on the 10-20 system developed by the International Electroencephalography Society in 1958. Each electrode records electrical discharges at a specific location on the scalp. The various waveform characteristics of the EEG are important for determining brain status and diagnosing brain diseases.

[0003] To overcome the physical limitations of high-density electrode arrays and improve the spatial resolution of scalp EEG at its source, researchers have combined focused ultrasound (FUS), known for its radiation-free nature, multiple focused targets, and high spatial resolution, with EEG to develop ultrasound-modulated EEG signals. However, when FUS is used to modulate EEG signals, it suffers from problems such as defocusing and insufficient focal energy, resulting in low EEG signal accuracy. Therefore, a scalp EEG signal acquisition method is urgently needed to improve its accuracy. Summary of the Invention

[0004] The embodiments of the present application provide a scalp brain signal acquisition method, system, medium and electronic device, which can improve the accuracy of scalp EEG signals.

[0005] In a first aspect, an embodiment of the present application provides a scalp brain signal acquisition method, which is applied to a scalp brain signal acquisition system. The scalp brain signal acquisition system includes a focused ultrasound irradiation module and an electroencephalogram (EEG) acquisition device; the EEG acquisition device includes EEG acquisition electrodes and an acquisition control module; the acquisition control module is used to control the EEG acquisition electrodes to acquire EEG signals; the focused ultrasound irradiation module includes an ultrasonic phased transducer; the method includes:

[0006] Determining FUS excitation signal parameters based on the head acoustic parameters; the excitation signal parameters are used to position the irradiation focus of the focused ultrasound FUS of the ultrasonic phased transducer on the scalp contour;

[0007] In response to an ultrasonic stimulation instruction, based on the excitation signal parameters, controlling the ultrasonic phased transducer to generate an array element excitation signal to perform ultrasonic irradiation on the irradiation focus;

[0008] In response to the EEG acquisition instruction, the EEG signal is acquired to obtain a focused ultrasound modulated scalp EEG signal.

[0009] The scalp brain signal acquisition method provided in the embodiments of the present application can determine the excitation signal parameters of the FUS based on the acoustic parameters of the head; the excitation signal parameters are used to locate the irradiation focus of the focused ultrasound FUS of the ultrasonic phased-control transducer on the scalp contour; in response to the ultrasonic stimulation instruction, the ultrasonic phased-control transducer is controlled to generate an array element excitation signal based on the excitation signal parameters to ultrasonically irradiate the irradiation focus; and in response to the EEG acquisition instruction, the EEG signal is acquired to obtain a focused ultrasound modulated scalp EEG signal, thereby setting the FUS focus on the scalp contour. This not only avoids the influence of the skull on the sound field, but also ensures high-precision focusing of the FUS, effectively improving the accuracy of the focused ultrasound scalp focus, and can improve the accuracy of the scalp EEG signal.

[0010] In a possible implementation, the scalp brain signal acquisition system further includes a simulation model construction module and an ultrasound focusing simulation module;

[0011] The method further comprises:

[0012] Based on the subject's head information and the irradiation structure parameters of the ultrasonic phased-control transducer, a biophysical simulation model is constructed in a preset coordinate system; the biophysical simulation model includes a head structure model and an irradiation structure contour of the ultrasonic phased-control transducer; the head structure model includes a scalp contour, a skull contour, and a brain tissue contour;

[0013] The head acoustic parameter is determined according to the Hounslow HU value included in the head information.

[0014] The scalp brain signal acquisition method provided in this embodiment constructs a biophysical simulation model in a preset coordinate system based on the subject's head information and the irradiation structure parameters of the ultrasonic phased transducer. The biophysical simulation model includes a head structure model and the irradiation structure contour of the ultrasonic phased transducer; the head structure model includes a scalp contour, a skull contour, and a brain tissue contour. The head acoustic parameters are determined based on the Hounslow HU value included in the head information, thereby establishing a biophysical simulation model based on the subject's head information, effectively improving the accuracy of the focused ultrasound scalp focus, and thus improving the accuracy of scalp EEG signals.

[0015] In one possible implementation, constructing a biophysical simulation model in a preset coordinate system based on the subject's head information and the irradiation structure parameters of the ultrasonic phased transducer includes:

[0016] Based on the subject's head information, a head structure model is constructed;

[0017] Based on the head structure model and the irradiation structure parameters of the ultrasonic phased-control transducer, a biophysical simulation model is constructed in a preset coordinate system.

[0018] The scalp brain signal acquisition method provided in this embodiment constructs a head structure model based on the subject's head information; based on the head structure model and the irradiation structure parameters of the ultrasonic phased-control transducer, a biophysical simulation model is constructed within a preset coordinate system. This method combines the head structure model, which includes the scalp contour, skull contour, and brain tissue contour, with the irradiation structure parameters of the ultrasonic phased-control transducer to obtain a biophysical simulation model. This method sets the FUS focus at the scalp contour, thus avoiding the skull's influence on the sound field while ensuring high-precision FUS focusing. This effectively improves the precision of the focused ultrasound scalp focus and can enhance the accuracy of scalp EEG signals.

[0019] In a possible implementation, the system further includes a data processing module; and the method further includes:

[0020] The focused ultrasound modulated scalp EEG signal is sent to a data processing module, so that the data processing module performs post-processing on the focused ultrasound modulated scalp EEG signal.

[0021] In the method provided in this embodiment, the system further includes a data processing module; the method further includes: sending the focused ultrasound modulated scalp EEG signal to the data processing module, so that the data processing module performs post-processing on the focused ultrasound modulated scalp EEG signal. This method sends the focused ultrasound modulated scalp EEG signal to the data processing module, so that the data processing module performs post-processing on the focused ultrasound modulated scalp EEG signal, and provides a data post-processing interface that can automatically post-process the focused ultrasound modulated scalp EEG signal, reducing the time spent on information processing of the focused ultrasound modulated scalp EEG signal and improving the processing efficiency of the scalp EEG signal.

[0022] In one possible implementation, the system further includes a cell discharge calculation module; after determining the FUS excitation signal parameters according to the head acoustic parameters, and before responding to the ultrasound stimulation instruction and controlling the ultrasonic phased transducer to generate the array element excitation signal based on the excitation signal parameters, the system further includes:

[0023] The irradiation amplitude is determined by the cell discharge calculation module; the irradiation amplitude is the maximum amplitude that makes the cell spontaneous discharge rhythm curve before and after ultrasonic stimulation meet the preset ultrasonic threshold condition; the ultrasonic threshold condition indicates that the influence of ultrasonic stimulation on cell discharge is less than the preset influence threshold.

[0024] The method provided in this embodiment determines the irradiation amplitude through the cell discharge calculation module. The irradiation amplitude is the maximum amplitude that allows the rhythmic curve of spontaneous cell discharge before and after ultrasound stimulation to meet a preset ultrasound threshold condition. The ultrasound threshold condition indicates that the degree of influence of ultrasound stimulation on cell discharge is less than a preset influence threshold. This method, through the cell discharge calculation module, determines the irradiation amplitude and sets a threshold condition that neither affects spontaneous cell discharge nor allows for high signal-to-noise ratio acquisition. This ensures the safety and effectiveness of focused ultrasound and further improves the accuracy of scalp EEG signals.

[0025] In a possible implementation, the system further includes a positioning module; and the method further includes:

[0026] The relative position of the ultrasonic phased-control transducer of the focused ultrasonic irradiation module and the irradiation focus is adjusted by the positioning module.

[0027] In the method provided in this embodiment, the system further includes a positioning module; the method further includes: adjusting, via the positioning module, the relative position of the ultrasonic phased-control transducer of the focused ultrasound irradiation module and the irradiation focus. This method, by adjusting the relative position of the ultrasonic phased-control transducer of the focused ultrasound irradiation module and the irradiation focus via the positioning module, can position the ultrasonic phased-control transducer of the focused ultrasound irradiation module relative to the irradiation focus, positioning the FUS focus on the scalp contour. This avoids the impact of the skull on the sound field while ensuring high-precision FUS focusing, effectively improving the accuracy of the focused ultrasound scalp focus and enhancing the accuracy of scalp EEG signals.

[0028] In a possible implementation, the system further includes a signal decoding module; and the method further includes:

[0029] In response to a source signal acquisition instruction, the signal decoding module performs high-frequency bandpass filtering on the focused ultrasound modulated scalp EEG signal when ultrasound irradiation is performed on each irradiation focus to obtain an ultrasound high-frequency signal;

[0030] Extracting an envelope signal from the acquired ultrasonic high-frequency signal to obtain an ultrasonic envelope signal;

[0031] Performing data segmentation and superposition averaging on the obtained ultrasonic envelope signal to obtain an ultrasonic decoding signal;

[0032] The ultrasonic decoded signal is subjected to grid scanning to obtain an EEG distribution map; the EEG distribution map includes a decoding value corresponding to each scanning grid point.

[0033] The method provided in this embodiment further comprises a signal decoding module; the method further comprises: in response to a source signal acquisition instruction, performing high-frequency bandpass filtering on the focused ultrasound modulated scalp EEG signal when ultrasound is irradiated at each irradiation focus by the signal decoding module to obtain an ultrasonic high-frequency signal; extracting an envelope signal from the obtained ultrasonic high-frequency signal to obtain an ultrasonic envelope signal; performing data segmentation and superposition averaging on the obtained ultrasonic envelope signal to obtain an ultrasonic decoded signal; performing raster scanning on the ultrasonic decoded signal to obtain an EEG distribution map; the EEG distribution map includes decoded values ​​corresponding to each scanning grid point. This method provides a decoding mechanism for ultrasonically modulated scalp EEG signals, decoding the scalp EEG signal at the ultrasound irradiation point by analyzing the typical characteristics of the ultrasonically modulated scalp EEG signal, accurately obtaining the source signal of the ultrasound irradiation target area, and improving the accuracy of the scalp EEG signal.

[0034] In a possible implementation, the head information includes head computed tomography (CT) scan information or magnetic resonance imaging (MRI) scan information.

[0035] In the method provided in this embodiment, the head information includes head computed tomography (CT) scan information or magnetic resonance imaging (MRI) scan information. This method can construct a biophysical simulation model based on this head CT scan information or MRI scan information, enabling accurate modeling of fine structures including scalp contours, skull contours, and brain tissue contours, thereby improving the accuracy of scalp EEG signals.

[0036] In a second aspect, an embodiment of the present application provides a scalp brain signal acquisition system, the system comprising:

[0037] A focused ultrasound irradiation module, configured to determine excitation signal parameters for FUS based on head acoustic parameters; the excitation signal parameters are used to position the irradiation focus of the focused ultrasound FUS of the ultrasonic phased-control transducer on the scalp contour; and in response to an ultrasonic stimulation instruction, control the ultrasonic phased-control transducer to generate an array element excitation signal based on the excitation signal parameters to perform ultrasonic irradiation on the irradiation focus;

[0038] The EEG acquisition device is used to respond to EEG acquisition instructions and acquire EEG signals to obtain focused ultrasound modulated scalp EEG signals; the EEG acquisition device includes EEG acquisition electrodes and an acquisition control module; the acquisition control module is used to control the EEG acquisition electrodes to acquire EEG signals.

[0039] In a possible implementation, the system further includes:

[0040] A simulation model construction module is used to construct a biophysical simulation model in a preset coordinate system based on the subject's head information and the irradiation structure parameters of the ultrasonic phased transducer; the biophysical simulation model includes a head structure model and the irradiation structure contour of the ultrasonic phased transducer; the head structure model includes a scalp contour, a skull contour, and a brain tissue contour;

[0041] The ultrasonic focusing simulation module is used to determine the head acoustic parameters according to the Hounslow HU value included in the head information.

[0042] In a possible implementation, the simulation model construction module includes a head structure reconstruction submodule and a coupling structure creation submodule;

[0043] The head structure reconstruction submodule is used to construct a head structure model based on the subject's head information;

[0044] The coupling structure creation submodule is used to construct a biophysical simulation model in a preset coordinate system based on the head structure model and the irradiation structure parameters of the ultrasonic phased transducer.

[0045] In a possible implementation, the system further includes a data processing module;

[0046] The EEG acquisition device is further configured to send the focused ultrasound modulated scalp EEG signal to the data processing module;

[0047] The data processing module is used to post-process the received focused ultrasound modulated scalp EEG signal.

[0048] In a possible implementation, the system further includes a cell discharge calculation module; the cell discharge calculation module is configured to:

[0049] Determine the irradiation amplitude; the irradiation amplitude is the maximum amplitude that makes the cell spontaneous discharge rhythm curve before and after ultrasonic stimulation meet the preset ultrasonic threshold condition; the ultrasonic threshold condition indicates that the influence of ultrasonic stimulation on cell discharge is less than the preset influence threshold.

[0050] In a possible implementation, the system further includes a positioning module; the positioning module is configured to adjust the relative position of the ultrasonic phased transducer of the focused ultrasonic irradiation module and the irradiation focus.

[0051] In a possible implementation, the system further includes a signal decoding module; the signal decoding module is configured to:

[0052] In response to a source signal acquisition instruction, performing high-frequency bandpass filtering on the focused ultrasound modulated scalp EEG signal when ultrasound irradiation is performed on each irradiation focus to acquire an ultrasound high-frequency signal;

[0053] Extracting an envelope signal from the acquired ultrasonic high-frequency signal to obtain an ultrasonic envelope signal;

[0054] Performing data segmentation and superposition averaging on the obtained ultrasonic envelope signal to obtain an ultrasonic decoding signal;

[0055] The ultrasonic decoded signal is subjected to grid scanning to obtain an EEG distribution map; the EEG distribution map includes a decoding value corresponding to each scanning grid point.

[0056] In a possible implementation, the head information includes head computed tomography (CT) scan information or magnetic resonance imaging (MRI) scan information.

[0057] In a third aspect, an embodiment of the present application provides a computer-readable storage medium, wherein the computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the method described in any one of the first aspects is implemented.

[0058] In a fourth aspect, an embodiment of the present application provides an electronic device comprising a memory and a processor, wherein the memory stores a computer program that can be run on the processor, and when the computer program is executed by the processor, the method described in any one of the first aspects is implemented.

[0059] In a fifth aspect, an embodiment of the present application provides a computer program product, which includes computer instructions, and the computer instructions are stored in a computer-readable storage medium; when the processor of a computer device reads the computer instructions from the computer-readable storage medium, the processor executes the computer instructions, so that the computer device performs the steps of any one of the methods described in the first aspect.

[0060] The technical effects brought about by any implementation method of the second to fifth aspects can refer to the technical effects brought about by the implementation method of the first aspect, and will not be repeated here. BRIEF DESCRIPTION OF THE DRAWINGS

[0061] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following is a brief introduction to the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0062] Figure 1 A flowchart of a scalp brain signal acquisition method provided in an embodiment of the present application;

[0063] Figure 2A flowchart of another scalp brain signal acquisition method provided in an embodiment of the present application;

[0064] Figure 3 A schematic diagram of a process for constructing a biophysical simulation model for a scalp brain signal acquisition method provided in an embodiment of the present application;

[0065] Figure 4 A schematic diagram of a signal decoding process of a scalp brain signal acquisition method provided in an embodiment of the present application;

[0066] Figure 5 This is one of the structural block diagrams of a scalp brain signal acquisition system provided in an embodiment of the present application;

[0067] Figure 6 This is a second structural block diagram of a scalp brain signal acquisition system provided in an embodiment of the present application;

[0068] Figure 7 This is a third structural block diagram of another scalp brain signal acquisition system provided in an embodiment of the present application;

[0069] Figure 8 This is a fourth structural block diagram of another scalp brain signal acquisition system provided in an embodiment of the present application;

[0070] Figure 9 This is a fifth structural block diagram of another scalp brain signal acquisition system provided in an embodiment of the present application;

[0071] Figure 10 This is a sixth structural block diagram of another scalp brain signal acquisition system provided in an embodiment of the present application;

[0072] Figure 11 This is a seventh structural block diagram of another scalp brain signal acquisition system provided in an embodiment of the present application;

[0073] Figure 12 This is a structural block diagram of an electronic device provided in an embodiment of the present application. DETAILED DESCRIPTION

[0074] To make the objectives, technical solutions, and advantages of this application more clear, this application will be further described in detail below with reference to the accompanying drawings. Obviously, the embodiments described are only some of the embodiments of this application, not all of them. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of this application.

[0075] Electroencephalogram (EEG) is a technology that noninvasively records electrical activity in the brain and is currently being applied to research in cognitive science, cognitive psychology, neurolinguistics, and other brain sciences. Electrode caps are generally used in clinical testing and trials to accurately and quickly determine electrode placement and collect brain signals. Commercial electrode caps often use a 10-20 lead placement system, based on the 10-20 system developed by the International Electroencephalography Society in 1958. Each electrode records electrical discharges at a specific location on the scalp. The various waveform characteristics of the EEG are important for determining brain status and diagnosing brain diseases.

[0076] To overcome the physical limitations of high-density electrode arrays and improve the spatial resolution of scalp EEG at its source, researchers have combined focused ultrasound (FUS)—which offers advantages such as non-radiative properties, multiple focal targets, and high spatial resolution—with EEG to develop ultrasound-modulated EEG signals. When FUS is used to modulate EEG signals, problems such as ultrasound defocusing and insufficient focal energy can occur, resulting in low EEG signal accuracy. Therefore, a method for acquiring scalp EEG signals that improves their accuracy is urgently needed.

[0077] Based on this, the embodiments of the present application provide a scalp brain signal acquisition method, system, medium and electronic device. Among them, the scalp brain signal acquisition method is applied to a scalp brain signal acquisition system, which includes a focused ultrasound irradiation module and an electroencephalogram (EEG) acquisition device; the EEG acquisition device includes an EEG acquisition electrode and an acquisition control module; the acquisition control module is used to control the EEG acquisition electrode to acquire EEG signals; the focused ultrasound irradiation module includes an ultrasonic phased transducer; the method includes: determining the excitation signal parameters of the FUS according to the acoustic parameters of the head; the excitation signal parameters are used to make the irradiation focus of the focused ultrasound FUS of the ultrasonic phased transducer located on the scalp contour; responding to the ultrasonic stimulation instruction, based on the excitation signal parameters, controlling the ultrasonic phased transducer to generate an array element excitation signal to ultrasonically irradiate the irradiation focus; responding to the EEG acquisition instruction, acquiring the EEG signal to obtain a focused ultrasound modulated scalp EEG signal. This scalp brain signal acquisition method can set the FUS focus on the scalp contour, which not only avoids the influence of the skull on the sound field, but also ensures high-precision focusing of FUS, effectively improves the accuracy of the focused ultrasound scalp focus, and can improve the accuracy of scalp EEG signals.

[0078] To make the invention objectives, technical solutions, and advantages of the embodiments of this application more clear, this application will be further described in detail below with reference to the accompanying drawings. Obviously, the embodiments described are only some of the embodiments of this application, not all of them. All other embodiments derived by ordinary technicians in this field based on the embodiments of this application without making any creative efforts are within the scope of protection of this application.

[0079] The following further explains the scalp brain signal acquisition method provided in the embodiment of the present application. The scalp brain signal acquisition method provided in the present application is applied to a scalp brain signal acquisition system, which includes a focused ultrasound irradiation module and an EEG acquisition device; the EEG acquisition device includes EEG acquisition electrodes and an acquisition control module; the acquisition control module is used to control the EEG acquisition electrodes to acquire EEG signals; the focused ultrasound irradiation module includes an ultrasonic phase-controlled transducer; Figure 1 As shown, the following steps are included:

[0080] Step S101 : determining the excitation signal parameters of FUS according to the acoustic parameters of the head; the excitation signal parameters are used to make the irradiation focus of the focused ultrasound FUS of the ultrasonic phased transducer be located on the scalp contour.

[0081] In one embodiment of the present application, the propagation path and focal area of ​​ultrasound waves are calculated based on the Westervelt sound wave propagation equation and the Pennes biological heat conduction equation, and then the excitation parameters of the transducer are adjusted so that the ultrasound waves can be accurately and safely focused on the target area on the skull surface.

[0082] In some embodiments of the present application, the Westervelt acoustic wave propagation equation is specifically as follows:

[0083]

[0084] in, is the Laplace operator;

[0085] p is the sound pressure;

[0086] c is the speed of sound;

[0087] ρ is the material density;

[0088] t is the propagation time;

[0089] is the acoustic diffusion coefficient;

[0090] α is the absorption coefficient;

[0091] ω=2πf is the angular frequency;

[0092] f is the ultrasonic frequency;

[0093] β is the acoustic nonlinear coefficient.

[0094] In the above formula, the first and second terms represent the lossless propagation of linear waves, the third term represents the acoustic wave loss of the medium, and the fourth term represents the nonlinear propagation characteristics of the acoustic wave.

[0095] In some embodiments of the present application, the Pennes biological heat conduction equation is specifically as follows:

[0096]

[0097] in,

[0098] ρ is the medium density;

[0099] C r is the specific heat of the medium, and the medium refers to the medium in which ultrasound propagates;

[0100] T is the medium temperature;

[0101] t is the propagation time;

[0102] r ec is the thermal conductivity of the medium;

[0103] is the Laplace operator;

[0104] q is the heat generated per unit volume of the medium;

[0105] W B is the blood perfusion rate;

[0106] C B is the specific heat of blood flow.

[0107] In some embodiments of the present application, the head structure model and biophysical simulation model established above are used as simulation software, single / multi-focus targets are set, and the phase excitation signal of each array element is obtained based on the TM method (Traversal Modulation). The function an1(t) for sequentially exciting each array element of the ultrasonic phased transducer is:

[0108] an1(t)=gp1(t)×sin(2πf0t),

[0109] in,

[0110] gp1(t) is a Gaussian pulse function;

[0111] f0 is the ultrasonic center frequency;

[0112] t is the propagation time.

[0113] The Gaussian pulse function is a type of function; for a certain ultrasonic phased transducer, the ultrasonic center frequency is an inherent property and its value is fixed.

[0114] A separate domain point probe is correspondingly set for each array element, and a domain point probe is also set at the preset focus. The domain point probe is used to record the sound pressure signal.

[0115] When an1(t) excites each array element of the ultrasonic phased transducer one by one, a domain point probe is set at the preset target focus to record the sound pressure signal p emitted by each array element to the target focus in turn. i (t), p i (t) is fitted to generate a fitting signal, and the time t corresponding to the maximum sound pressure of the fitting signal is extracted i ; Calculate the t corresponding to each array element i The maximum value in is recorded as t0, and the array element corresponding to t0 is used as the reference array element. The delay phase between the remaining array elements and the reference array element is Δt i =t0-t i ; It can be obtained that the excitation signal of each array element after using the TM method is an TM_i (t):

[0116] an TM_i (t) = gp1(t-Δt i )×sin(2πf0(t-Δt i )).

[0117] In some embodiments of the present application, the excitation signal parameter of the FUS includes an excitation signal phase.

[0118] In some other embodiments of the present application, the excitation signal parameters of the FUS include an excitation signal amplitude and an excitation signal phase.

[0119] In some embodiments of the present application, the phase of the excitation signal is a preset fixed value.

[0120] Step S102 : responding to the ultrasonic stimulation instruction, controlling the ultrasonic phased-control transducer to generate an array element excitation signal based on the excitation signal parameters, so as to perform ultrasonic irradiation on the irradiation focus.

[0121] In a specific implementation, after determining the excitation signal parameters of the FUS, the user triggers an ultrasound stimulation instruction. In response to the received ultrasound stimulation instruction, the ultrasonic phased transducer is controlled to generate an array element excitation signal based on the excitation signal parameters to perform ultrasound irradiation on the irradiation focus.

[0122] In an optional embodiment, the system further includes a positioning module; and the method further includes:

[0123] The relative position of the ultrasonic phased-control transducer of the focused ultrasonic irradiation module and the irradiation focus is adjusted through the positioning module.

[0124] In some embodiments of the present application, the ultrasonic phased transducer includes a phase control unit, a power amplification unit, an electronic three-dimensional adjustment unit, a sound field scanning unit and a positioning unit; after the delay phase is calculated by the TM method, the delay signal of each array element including the delay phase is sent to the phase control unit through the serial port; the phase control unit triggers the array element excitation signal according to the delay sequence, and sends it to the power amplification unit in sequence; the power amplification unit generates an array element excitation signal of a set amplitude according to the stimulation sequence, and excites each array element to emit a sound wave.

[0125] The ultrasonic phased transducer is placed at the corresponding position in the simulation through the electronic three-dimensional adjustment unit, the sound field scanning unit and the positioning unit. While ensuring the consistency of the sound fields of the experiment and the simulation, the preset target point on the skull surface of the subject is further irradiated.

[0126] Step S103 , responding to the EEG acquisition instruction, acquiring EEG signals to obtain focused ultrasound modulated scalp EEG signals.

[0127] The collection of focused ultrasound modulated scalp EEG signals needs to be carried out in an environment with good sound insulation, good air circulation, no strong light and no electromagnetic interference. Before the experiment begins, the subject adjusts his sitting posture to the optimal position on his own, and then the examiner puts on the electrode cap for the subject, and adjusts the impedance of all leads to be no greater than the preset impedance value, such as 5kΩ. In the embodiment of the present application, the EEG amplifier example uses the Neuroscan Curry9 system, selects appropriate reference electrodes and ground electrodes, and sets the system sampling rate and power frequency notch, etc. After the EEG signal waveform of the subject is stable, collect a section of EEG signal before ultrasonic stimulation for reference; start the scalp brain signal acquisition system, perform ultrasonic irradiation according to the excitation signal parameters obtained by simulation, and collect a section of EEG signal during ultrasonic irradiation for information processing.

[0128] The scalp brain signal acquisition method provided in the above embodiment can determine the excitation signal parameters of the FUS based on the acoustic parameters of the head; the excitation signal parameters are used to locate the irradiation focus of the focused ultrasound FUS of the ultrasonic phased-control transducer on the scalp contour; in response to the ultrasonic stimulation instruction, the ultrasonic phased-control transducer is controlled to generate the array element excitation signal based on the excitation signal parameters to ultrasonically irradiate the irradiation focus; in response to the EEG acquisition instruction, the EEG signal is acquired to obtain a focused ultrasound modulated scalp EEG signal, thereby setting the FUS focus on the scalp contour, avoiding the influence of the skull on the sound field, ensuring high-precision focusing of the FUS, effectively improving the accuracy of the focused ultrasound scalp focus, and improving the accuracy of the scalp EEG signal.

[0129] In an optional embodiment, the scalp brain signal acquisition system further includes a simulation model construction module and an ultrasound focusing simulation module; Figure 2 , the method further comprises the following steps:

[0130] Step S201 : constructing a biophysical simulation model in a preset coordinate system based on the subject's head information and the irradiation structure parameters of the ultrasonic phased-control transducer.

[0131] Among them, the biophysical simulation model includes a head structure model and an irradiation structure contour of an ultrasonic phased-control transducer; the head structure model includes a scalp contour, a skull contour, and a brain tissue contour.

[0132] In an optional embodiment, the head information includes head computed tomography (CT) scan information, or magnetic resonance imaging (MRI) scan information.

[0133] In an optional embodiment, based on the subject's head information and the irradiation structure parameters of the ultrasonic phased transducer, a process of constructing a biophysical simulation model in a preset coordinate system is as follows: Figure 3 As shown, the following steps may be included:

[0134] Step S301: construct a head structure model based on the subject's head information.

[0135] In a specific implementation, the head information can be head CT scan information or head MRI scan information. In some embodiments of the present application, a head structure model is established based on the subject's head electronic computed tomography (CT) / magnetic resonance imaging (MRI) scan data.

[0136] In some embodiments of the present application, the skull comprises a three-layer skull structure of outer cortical bone, middle cancellous bone, and inner cortical bone. The skull outline is the outline of the outer cortical bone.

[0137] In one embodiment of the present application, a head structure model is constructed based on the subject's head information. Specifically, a three-dimensional skull discrete data map is established based on the subject's skull CT data. Furthermore, a numerical simulation model of the head structure is established based on the fine structures such as the outer cortical bone, middle cancellous bone, and inner cortical bone skull structure divided by the Hounsfield Unit (HU) value of the CT image, as well as the scalp and brain tissue.

[0138] Step S302 : constructing a biophysical simulation model in a preset coordinate system based on the head structure model and the irradiation structure parameters of the ultrasonic phased-control transducer.

[0139] In specific implementations, the subject's head information, such as the HU value from CT data, is used to construct a head structure model. This is then combined with the irradiation structural parameters of the ultrasonic phased-control transducer to establish a biophysical simulation model consistent with actual applications. The ultrasonic phased-control transducer structural parameters include, but are not limited to, the following information items: transducer shape, number of array elements, aperture diameter, array element diameter, array element spacing, and transducer geometric focal length.

[0140] Step S202: determining head acoustic parameters according to the Hounslow HU value included in the head information.

[0141] During specific implementation, the head acoustic parameters corresponding to the head structure model are determined according to the Hounslow HU value included in the head information.

[0142] The scalp brain signal acquisition method provided in the above embodiment can construct a biophysical simulation model in a preset coordinate system based on the subject's head information and the irradiation structure parameters of the ultrasonic phased transducer; the biophysical simulation model includes a head structure model and an irradiation structure contour of the ultrasonic phased transducer; the head structure model includes a scalp contour, a skull contour, and a brain tissue contour; the head acoustic parameters are determined based on the Hounsfield HU value included in the head information; the FUS excitation signal parameters are determined based on the head acoustic parameters; the excitation signal parameters are used to make the ultrasonic phased transducer focus the ultrasonic FUS The irradiation focus is located on the scalp contour; in response to the ultrasonic stimulation instruction, based on the excitation signal parameters, the ultrasonic phased transducer is controlled to generate the array element excitation signal to perform ultrasonic irradiation on the irradiation focus; in response to the EEG acquisition instruction, the EEG signal is acquired to obtain the focused ultrasound modulated scalp EEG signal, thereby establishing a biophysical simulation model based on the subject's head information and setting the FUS focus on the scalp contour, which not only avoids the influence of the skull on the sound field, but also ensures the high-precision focusing of the FUS, effectively improving the accuracy of the focused ultrasound scalp focus, and can improve the accuracy of the scalp EEG signal.

[0143] In the embodiments of the present application, the acoustic parameters include but are not limited to the following information items: medium porosity, material density, sound velocity, and absorption coefficient of the corresponding area.

[0144] In an optional embodiment, the calculation formulas for the head acoustic parameters of each part of the head structure model are as follows:

[0145]

[0146] ρ=Φ×ρ water +(1-Φ)×ρ bone ,

[0147] c=c water +(1-Φ)×(c bone -c water ),

[0148] α=α water +Φ 0.5 ×(α bone -α water ),

[0149] Where Φ is the porosity of the medium in the corresponding area;

[0150] α bone 、c bone and ρ bone They represent the absorption coefficient, speed of sound, and density of the skull in turn;

[0151] α water 、c water and ρ water They represent the absorption coefficient, sound velocity, and density of water respectively;

[0152] H is the Heinz value;

[0153] ρ is the material density of the corresponding area;

[0154] c is the speed of sound in the corresponding area;

[0155] α is the absorption coefficient of the corresponding area.

[0156] In the embodiment of the present application, the corresponding area is the area of ​​the selected points in each part of the head structure model. In an optional embodiment, the system further includes a data processing module; after step S103, the scalp brain signal acquisition method further includes:

[0157] The focused ultrasound modulated scalp EEG signal is sent to a data processing module, so that the data processing module performs post-processing on the focused ultrasound modulated scalp EEG signal.

[0158] In an optional embodiment, the system further includes a cell discharge calculation module; after determining the FUS excitation signal parameters according to the head acoustic parameters, and before responding to the ultrasound stimulation instruction and controlling the ultrasound phased transducer to generate the array element excitation signal based on the excitation signal parameters, the system further includes:

[0159] The irradiation amplitude is determined by the cell discharge calculation module; the irradiation amplitude is the maximum amplitude that makes the cell spontaneous discharge rhythm curve before and after ultrasonic stimulation meet the preset ultrasonic threshold condition; the ultrasonic threshold condition indicates that the influence of ultrasonic stimulation on cell discharge is less than the preset influence threshold.

[0160] In an embodiment of the present application, the cell discharge calculation module may include an ultrasound-modulated cell discharge sub-model; the ultrasound-modulated cell discharge sub-model is obtained by combining a bilayer sonophore (BLS) model and a cell model based on Hodgkin-Huxley (HH).

[0161] In an embodiment of the present application, an ultrasound-modulated cell discharge sub-model is used to determine a threshold range of ultrasound irradiation parameters.

[0162] When sinusoidal ultrasound is applied to the cell bilayer membrane, the maximum displacement Z of the lipid membrane relative to its resting position satisfies the following RP equation (Rayleigh-Plesset formula):

[0163]

[0164] The curvature radius of the cell bilayer leaflet is R(Z) = (r a 2 +Z 2 ) / (2Z);

[0165] r a is the diaphragm radius;

[0166] ρ1 is the density of cerebrospinal fluid (CSF);

[0167] ω=2πf is the angular frequency of the ultrasonic wave;

[0168] f is the center frequency;

[0169] t is the propagation time;

[0170] P in ,P M ,P ec ,P0,P A and P S (Z) are the pressures generated by internal gas pressure, molecular pressure, electrostatic pressure, static pressure, amplitude of applied ultrasound, and leaflet tension;

[0171] δ0 is the thickness of the leaflet;

[0172] μ s is the dynamic viscosity of the leaflet;

[0173] μ1 is the dynamic viscosity of CSF.

[0174] Membrane capacitance C m and displacement Z i The related function is:

[0175]

[0176] in,

[0177] C m (Z i ) is the maximum displacement Z of the lipid membrane relative to its rest position i The membrane capacitance at ;

[0178] C m0 is the membrane capacitance of the lipid bilayer at rest (P A =0Pa);

[0179] r a is the diaphragm radius;

[0180] Z i For different ultrasonic irradiation conditions, the maximum displacement of the lipid membrane corresponding to each ultrasonic irradiation condition relative to its static position, i represents the number of ultrasonic irradiation conditions;

[0181] Δ is the distance between leaflets.

[0182] The capacitive displacement current is:

[0183]

[0184] Where V is the membrane potential;

[0185] C m is the membrane capacitance;

[0186] t is the propagation time.

[0187] The interlobular distances between different cell types are constant.

[0188] The HH equation for cell discharge under ultrasound irradiation is:

[0189]

[0190] in,

[0191] I Na , I K , I A , I T , I L , I K-Ca and I l They are sodium current, delayed rectifier K + Current, A-type K + Current, low threshold Ca 2+ Current, high threshold Ca 2+ Current, Ca-dependent 2+ K + Current and leakage current;

[0192] I D is the capacitive displacement current;

[0193] C m is the membrane capacitance;

[0194] V is the membrane potential.

[0195] The calculation formula of each ion membrane current is:

[0196] I Na =g Na m 3 h(VV Na ),

[0197] I K =g K n 4 (VV K ),

[0198] I A =g A a 2 b(VV K ),

[0199] I T =g T p 2 q(VV Ca ),

[0200] I L =g L c 2 d1d2(VV Ca ),

[0201] I K-Ca =g K-Ca r 2 (VV K ),

[0202] I l =g l (VV l ),

[0203] Among them, a, b, c, d1, d2, h, m, n, p, q and r are activation or inactivation variables (under fixed conditions, activation or inactivation variables are fixed values);

[0204] V Na 、V K 、V Ca and V l are the reversal potentials of sodium, potassium, calcium, and leakage current, respectively;

[0205] g Na 、g K 、gA 、g L 、g T 、g K-Ca and g l is the maximum conductance.

[0206] Ultrasonic spatial peak pulse average (SPPA) intensity I sppa The calculation formula is:

[0207]

[0208] Where c is the speed of sound;

[0209] P A Indicates the sound pressure amplitude;

[0210] ρ1 represents the density of the ultrasound propagation medium.

[0211] Cell firing rhythm si for:

[0212] f si =1 / Δt si ,

[0213] Wherein, the time interval Δt between two consecutive discharge spikes is si for:

[0214] Δt si =t i+1 -t i ,

[0215] t i is the time of the i-th spike discharged by the cell.

[0216] In some embodiments of the present application, sppa =0W / m 2 The rhythm curve of spontaneous cell discharge during stimulation was used as a benchmark, and the discharge rhythm curve after ultrasound stimulation was correlated with it by Pearson correlation. The frequency difference between the two was calculated, and the Pearson correlation coefficient before and after stimulation was set to be greater than or equal to 0.9. The effect of ultrasound stimulation on cell discharge was negligible, which was the safe and effective ultrasound threshold condition.

[0217] In some embodiments of the present application, the purpose of using ultrasound is spatial positioning, so that the impact of ultrasound on scalp cells is as small as possible. Therefore, in some embodiments of the present application, an ultrasound threshold condition is set to ensure that the irradiation energy of ultrasound on the scalp does not exceed the impact threshold of the ultrasound threshold condition.

[0218] In some embodiments of the present application, signal decoding may also be performed on the focused ultrasound modulated scalp EEG signal.

[0219] In an optional embodiment, the system further includes a signal decoding module; the method, such as Figure 4 As shown, the following steps are also included:

[0220] Step S401 , in response to a source signal acquisition instruction, a signal decoding module performs high-frequency bandpass filtering on the focused ultrasound modulated scalp EEG signal when ultrasound irradiation is performed on each irradiation focus to obtain an ultrasound high-frequency signal.

[0221] Step S402: extracting an envelope signal from the acquired ultrasonic high-frequency signal to obtain an ultrasonic envelope signal.

[0222] Step S403 : performing data segmentation and superposition averaging on the obtained ultrasonic envelope signal to obtain an ultrasonic decoding signal.

[0223] Step S404 , performing raster scanning on the ultrasonic decoded signal to obtain an EEG distribution map; the EEG distribution map includes a decoding value corresponding to each scanning grid point.

[0224] In some embodiments of the present application, the voltage signal collected by Curry9 when each target point is irradiated with ultrasound is used as the original data, and the original data is preprocessed by removing 50Hz power frequency interference and downsampling to 4kHz; the preprocessed data is band-pass filtered at the ultrasound pulse repetition frequency (PRF) ±50Hz to retain the high-frequency signal at the PRF; the envelope signal of the high-frequency signal that passes the band-pass filter is extracted using Hilbert transform; 20s of envelope signal data is selected and divided into 20 segments of data with an interval of 1s, the data is peak aligned, and superimposed and averaged to obtain a 1s envelope signal, which is the decoded signal of the ultrasound irradiation point; the decoded signal of each point during ultrasound raster scanning can be used to obtain a high-spatial-resolution EEG distribution map of the region of interest (ROI) on the scalp surface.

[0225] In some embodiments of the present application, the decoding signal of each point during ultrasonic grid scanning is used, specifically, ultrasonic grid scanning is used, and the data collected from each scanning point is passed through a data processing module to obtain a decoding value corresponding to each scanning grid point.

[0226] In some embodiments of the present application, the decoded value corresponding to each scanning grid point includes the amplitude of the decoded signal.

[0227] In some embodiments of the present application, the area scanned by ultrasound is the area of ​​interest. By scanning each point with ultrasound, the amplitude of the decoded signal of each point is decoded, and these values ​​are plotted as a distribution diagram to obtain a high spatial resolution EEG distribution diagram.

[0228] The scalp brain signal acquisition method provided in the above embodiment can determine the excitation signal parameters of FUS based on the acoustic parameters of the head; the excitation signal parameters are used to locate the irradiation focus of the focused ultrasound FUS of the ultrasonic phased transducer on the scalp contour; in response to the ultrasonic stimulation instruction, the ultrasonic phased transducer is controlled to generate the array element excitation signal based on the excitation signal parameters to ultrasonically irradiate the irradiation focus; in response to the EEG acquisition instruction, the EEG signal is acquired to obtain a focused ultrasound modulated scalp EEG signal, thereby setting the FUS focus on the scalp contour, avoiding the influence of the skull on the sound field, and ensuring high-precision focusing of the FUS, effectively improving the accuracy of the focused ultrasound scalp focus, and can improve the accuracy of the scalp EEG signal.

[0229] Based on the same inventive concept, the present invention also provides a scalp brain signal acquisition system. Since this system corresponds to the scalp brain signal acquisition method of the present invention and the principles of solving the problem are similar to those of the method, the implementation of this system can be referred to as the implementation of the above method, and the repeated parts will not be repeated here.

[0230] Figure 5 FIG. 1 shows a schematic structural diagram of a scalp brain signal acquisition system provided in an embodiment of the present application. The scalp brain signal acquisition system is as follows: Figure 5 As shown, it includes: a focused ultrasound irradiation module 501 and an EEG acquisition device 502.

[0231] The focused ultrasound irradiation module 501 is configured to determine the excitation signal parameters of the FUS based on the acoustic parameters of the head; the excitation signal parameters are used to position the irradiation focus of the focused ultrasound FUS of the ultrasonic phased-control transducer on the scalp contour; and in response to the ultrasonic stimulation instruction, control the ultrasonic phased-control transducer to generate the array element excitation signal based on the excitation signal parameters to perform ultrasonic irradiation on the irradiation focus.

[0232] The EEG acquisition device 502 is used to respond to EEG acquisition instructions and acquire EEG signals to obtain focused ultrasound modulated scalp EEG signals; the EEG acquisition device includes EEG acquisition electrodes and an acquisition control module; the acquisition control module is used to control the EEG acquisition electrodes to acquire EEG signals.

[0233] In the embodiment of the present application, the EEG acquisition device may also be referred to as an EEG acquisition device module.

[0234] In one possible implementation, Figure 6 As shown, the system also includes:

[0235] A simulation model construction module 601 is configured to construct a biophysical simulation model in a preset coordinate system based on the subject's head information and the irradiation structure parameters of the ultrasonic phased-control transducer; the biophysical simulation model includes a head structure model and an irradiation structure contour of the ultrasonic phased-control transducer; the head structure model includes a scalp contour, a skull contour, and a brain tissue contour;

[0236] The ultrasound focusing simulation module 602 is used to determine the head acoustic parameters according to the Hounslow HU value included in the head information.

[0237] In one possible implementation, Figure 7 As shown, the simulation model construction module 601 includes a head structure reconstruction submodule 701 and a coupling structure creation submodule 702;

[0238] The head structure reconstruction submodule 701 is used to construct a head structure model based on the subject's head information;

[0239] The coupling structure creation submodule 702 is used to construct a biophysical simulation model in a preset coordinate system based on the head structure model and the irradiation structure parameters of the ultrasonic phased-control transducer.

[0240] In one possible implementation, Figure 8 As shown, the system further includes a data processing module 801;

[0241] The EEG acquisition device 502 is also used to send the focused ultrasound modulated scalp EEG signal to the data processing module 801;

[0242] The data processing module 801 is used to post-process the received focused ultrasound modulated scalp EEG signal.

[0243] In one possible implementation, Figure 9 As shown, the system further includes a cell discharge calculation module 901; the cell discharge calculation module 901 is used to:

[0244] Determine the irradiation amplitude; the irradiation amplitude is the maximum amplitude that makes the cell spontaneous discharge rhythm curve before and after ultrasonic stimulation meet the preset ultrasonic threshold condition; the ultrasonic threshold condition indicates that the influence of ultrasonic stimulation on cell discharge is less than the preset influence threshold.

[0245] In some embodiments of the present application, the irradiation amplitude determined by the cell discharge calculation module 901 can be used to adjust the excitation signal amplitude included in the excitation signal parameters based on the irradiation amplitude to obtain adjusted excitation signal parameters; the adjusted excitation signal parameters are used by the focused ultrasound irradiation module 501 to respond to the ultrasound stimulation instruction and control the ultrasonic phased-control transducer to generate the array element excitation signal to perform ultrasonic irradiation at the irradiation focus. That is, upon receiving the ultrasound stimulation instruction, the focused ultrasound irradiation module 501 controls the ultrasonic phased-control transducer to generate the array element excitation signal based on the adjusted excitation signal parameters to perform ultrasonic irradiation at the irradiation focus in response to the received ultrasound stimulation instruction.

[0246] In some embodiments of the present application, adjusting the excitation signal amplitude included in the excitation signal parameters based on the irradiation amplitude includes: if the excitation signal amplitude included in the excitation signal parameters is less than the irradiation amplitude, keeping the excitation signal amplitude included in the excitation signal parameters unchanged; if the excitation signal amplitude included in the excitation signal parameters is greater than the irradiation amplitude, reducing the excitation signal amplitude included in the excitation signal parameters to the irradiation amplitude.

[0247] In some embodiments of the present application, adjusting the excitation signal amplitude included in the excitation signal parameters based on the irradiation amplitude includes: if the excitation signal amplitude included in the excitation signal parameters is less than the irradiation amplitude, keeping the excitation signal amplitude included in the excitation signal parameters unchanged; if the excitation signal amplitude included in the excitation signal parameters is greater than the irradiation amplitude, reducing the excitation signal amplitude included in the excitation signal parameters to a target irradiation amplitude; wherein the target irradiation amplitude is the product of the irradiation amplitude and a preset safety factor; and the value range of the preset safety factor is (0,1).

[0248] In one possible implementation, Figure 10 As shown, the system further includes a positioning module 1001; the positioning module 1001 is used to adjust the relative position of the ultrasonic phased transducer of the focused ultrasonic irradiation module and the irradiation focus.

[0249] In one possible implementation, Figure 11 As shown, the system further includes a signal decoding module 1101; the signal decoding module 1101 is used to:

[0250] In response to a source signal acquisition instruction, performing high-frequency bandpass filtering on the focused ultrasound modulated scalp EEG signal when performing ultrasound irradiation on each irradiation focus to acquire an ultrasound high-frequency signal;

[0251] extracting an envelope signal from the acquired ultrasonic high-frequency signal to obtain an ultrasonic envelope signal;

[0252] Performing data segmentation and superposition averaging on the obtained ultrasonic envelope signal to obtain an ultrasonic decoding signal;

[0253] The ultrasonic decoded signal is raster scanned to obtain an EEG distribution map; the EEG distribution map includes a decoded value corresponding to each scanned grid point.

[0254] In a possible implementation, the head information includes head computed tomography (CT) scan information or magnetic resonance imaging (MRI) scan information.

[0255] Based on the same inventive concept as the above method embodiment, an electronic device is also provided in the embodiment of the present application. The electronic device can be used for brain signal acquisition. In one embodiment, the electronic device can be a server or other electronic device. In this embodiment, the structure of the electronic device can be as follows: Figure 12 As shown, it includes a memory 1201 , a communication module 1203 and one or more processors 1202 .

[0256] Memory 1201 is used to store computer programs executed by processor 1202. Memory 1201 may primarily include a program storage area and a data storage area. The program storage area may store an operating system and programs required for running instant messaging functions, while the data storage area may store various instant messaging messages and operating instruction sets.

[0257] Memory 1201 may be a volatile memory, such as random-access memory (RAM); or a non-volatile memory, such as read-only memory, flash memory, a hard disk drive (HDD), or a solid-state drive (SSD); or any other medium capable of carrying or storing desired program code in the form of instructions or data structures and accessible by a computer, but is not limited thereto. Memory 1201 may be a combination of the aforementioned memories.

[0258] The processor 1202 may include one or more central processing units (CPUs) or digital processing units, etc. The processor 1202 is configured to implement the above-mentioned scalp brain signal acquisition method when calling the computer program stored in the memory 1201 .

[0259] The communication module 1203 is used to communicate with terminal devices or other servers.

[0260] The specific connection medium between the memory 1201, the communication module 1203 and the processor 1202 is not limited in the embodiment of the present application. Figure 12In the embodiment, the memory 1201 and the processor 1202 are connected via a bus 1204. The bus 1204 is connected to the processor 1202 via a bus 1204. Figure 12 The connections between the other components are shown in bold lines, which are only for illustration and are not intended to be limiting. The bus 1204 can be divided into an address bus, a data bus, a control bus, etc. For ease of illustration, Figure 12 Only one thick line is used in the diagram, but this does not mean that there is only one bus or one type of bus.

[0261] An embodiment of the present application further provides a computer-readable storage medium, in which computer-executable instructions are stored. The computer-executable instructions are used to implement the scalp brain signal acquisition method of any embodiment of the present application.

[0262] According to one aspect of the present application, a computer program product or computer program is provided, comprising computer instructions stored in a computer-readable storage medium. A processor of a computer device reads the computer instructions from the computer-readable storage medium and executes the computer instructions, causing the computer device to perform the scalp brain signal acquisition method described in the above-described embodiment. The program product may employ any combination of one or more readable media. The readable medium may be a readable signal medium or a readable storage medium. The readable storage medium may be, for example, but not limited to, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any combination thereof. More specific examples (a non-exhaustive list) of readable storage media include: an electrical connection having one or more wires, a portable disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination thereof.

[0263] The above is only a specific implementation method of the present application, but the scope of protection of the present application is not limited thereto. Any technician familiar with this technical field can easily think of changes or replacements within the technical scope disclosed in this application, which should be covered by the scope of protection of the present application.

Claims

1. A scalp brain signal acquisition method, applied to a scalp brain signal acquisition system, characterized in that: The scalp brain signal acquisition system includes a focused ultrasound irradiation module and an EEG acquisition device; the EEG acquisition device includes EEG acquisition electrodes and an acquisition control module; the acquisition control module is used to control the EEG acquisition electrodes to acquire EEG signals; The focused ultrasound irradiation module includes an ultrasonic phased-control transducer; the method includes: determining an FUS excitation signal parameter based on head acoustic parameters; the excitation signal parameter is used to position the irradiation focus of the focused ultrasound FUS of the ultrasonic phased-control transducer on the scalp contour; In response to an ultrasonic stimulation instruction, based on the excitation signal parameters, controlling the ultrasonic phased transducer to generate an array element excitation signal to perform ultrasonic irradiation on the irradiation focus; In response to the EEG acquisition instruction, the EEG signal is acquired to obtain a focused ultrasound modulated scalp EEG signal.

2. The method according to claim 1, characterized in that The scalp brain signal acquisition system also includes a simulation model construction module and an ultrasound focusing simulation module; The method further comprises: Based on the subject's head information and the irradiation structure parameters of the ultrasonic phased-control transducer, a biophysical simulation model is constructed in a preset coordinate system; the biophysical simulation model includes a head structure model and an irradiation structure contour of the ultrasonic phased-control transducer; the head structure model includes a scalp contour, a skull contour, and a brain tissue contour; The head acoustic parameter is determined according to the Hounslow HU value included in the head information.

3. The method according to claim 2, characterized in that The method of constructing a biophysical simulation model in a preset coordinate system based on the subject's head information and the irradiation structure parameters of the ultrasonic phased transducer includes: Based on the subject's head information, a head structure model is constructed; Based on the head structure model and the irradiation structure parameters of the ultrasonic phased-control transducer, a biophysical simulation model is constructed in a preset coordinate system.

4. The method according to claim 1, wherein The system further includes a data processing module; and the method further includes: The focused ultrasound modulated scalp EEG signal is sent to a data processing module, so that the data processing module performs post-processing on the focused ultrasound modulated scalp EEG signal.

5. The method according to claim 1, wherein The system further includes a cell discharge calculation module; after determining the FUS excitation signal parameters according to the head acoustic parameters, and before responding to the ultrasound stimulation instruction and controlling the ultrasound phased transducer to generate an array element excitation signal based on the excitation signal parameters, the system further includes: The irradiation amplitude is determined by the cell discharge calculation module; the irradiation amplitude is the maximum amplitude that makes the cell spontaneous discharge rhythm curve before and after ultrasonic stimulation meet the preset ultrasonic threshold condition; the ultrasonic threshold condition indicates that the influence of ultrasonic stimulation on cell discharge is less than the preset influence threshold.

6. The method according to claim 1, characterized in that The system further includes a positioning module; and the method further includes: The relative position of the ultrasonic phased-control transducer of the focused ultrasonic irradiation module and the irradiation focus is adjusted by the positioning module.

7. The method according to claim 1, characterized in that The system further includes a signal decoding module; and the method further includes: In response to a source signal acquisition instruction, the signal decoding module performs high-frequency bandpass filtering on the focused ultrasound modulated scalp EEG signal when ultrasound irradiation is performed on each irradiation focus to obtain an ultrasound high-frequency signal; Extracting an envelope signal from the acquired ultrasonic high-frequency signal to obtain an ultrasonic envelope signal; Performing data segmentation and superposition averaging on the obtained ultrasonic envelope signal to obtain an ultrasonic decoding signal; The ultrasonic decoded signal is subjected to grid scanning to obtain an EEG distribution map; the EEG distribution map includes a decoding value corresponding to each scanning grid point.

8. The method according to claim 2, characterized in that The head information includes head electronic computed tomography (CT) scanning information or magnetic resonance imaging (MRI) scanning information.

9. A scalp brain signal acquisition system, characterized in that: The system comprises: A focused ultrasound irradiation module, configured to determine excitation signal parameters for FUS based on head acoustic parameters; the excitation signal parameters are used to position the irradiation focus of the focused ultrasound FUS of the ultrasonic phased-control transducer on the scalp contour; and in response to an ultrasonic stimulation instruction, control the ultrasonic phased-control transducer to generate an array element excitation signal based on the excitation signal parameters to perform ultrasonic irradiation on the irradiation focus; The EEG acquisition device is used to respond to EEG acquisition instructions and acquire EEG signals to obtain focused ultrasound modulated scalp EEG signals; the EEG acquisition device includes EEG acquisition electrodes and an acquisition control module; the acquisition control module is used to control the EEG acquisition electrodes to acquire EEG signals.

10. The system according to claim 9, characterized in that The system further comprises: A simulation model construction module is used to construct a biophysical simulation model in a preset coordinate system based on the subject's head information and the irradiation structure parameters of the ultrasonic phased transducer; the biophysical simulation model includes a head structure model and the irradiation structure contour of the ultrasonic phased transducer; the head structure model includes a scalp contour, a skull contour, and a brain tissue contour; The ultrasonic focusing simulation module is used to determine the head acoustic parameters according to the Hounslow HU value included in the head information.

11. The system according to claim 9, wherein: The system also includes a data processing module; The EEG acquisition device is further configured to send the focused ultrasound modulated scalp EEG signal to the data processing module; The data processing module is used to post-process the received focused ultrasound modulated scalp EEG signal.

12. The system according to claim 9, wherein: The system further includes a cell discharge calculation module; the cell discharge calculation module is used to: Determine the irradiation amplitude; the irradiation amplitude is the maximum amplitude that makes the cell spontaneous discharge rhythm curve before and after ultrasonic stimulation meet the preset ultrasonic threshold condition; the ultrasonic threshold condition indicates that the influence of ultrasonic stimulation on cell discharge is less than the preset influence threshold.

13. The system according to claim 9, wherein: The system further includes a positioning module; the positioning module is used to adjust the relative position of the ultrasonic phased-control transducer of the focused ultrasonic irradiation module and the irradiation focus.

14. An electronic device, characterized in that: The method comprises a memory and a processor, wherein the memory stores a computer program that can be run on the processor, and when the computer program is executed by the processor, the method according to any one of claims 1 to 8 is implemented.

15. A computer-readable storage medium storing a computer program, wherein: When the computer program is executed by a processor, the method according to any one of claims 1 to 8 is implemented.

16. A computer program product, characterized in that It includes computer instructions, which are stored in a computer-readable storage medium; when a processor of a computer device reads the computer instructions from the computer-readable storage medium, the processor executes the computer instructions, so that the computer device performs the steps of the method according to any one of claims 1 to 8.

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