Multifunctional hand cream and preparation method thereof

Abstract

The present invention relates to a multifunctional hand cream and a preparation method thereof, and belongs to the technical field of hand creams. The multifunctional hand cream of the present invention is composed of the following raw materials by weight: 0.1-1 parts of recombinant collagen treated with liposomes, 0.1-1 parts of Centella asiatica extract, 0.05-0.2 parts of lactobacillus / soy milk fermentation, 0.05-0.2 parts of peach resin extract, 0.05-0.2 parts of palmitoyl tripeptide-10.0001-0.001 parts, palmitoyl tetrapeptide-70.00005-0.0005 parts, acetyl hexapeptide-80.0005-0.005 parts, 58-92 parts of aqueous phase, 7.55-36.3 parts of oil phase and 1.07-5.2 parts of auxiliary materials. The waterproof performance of the hand cream is increased by high carbon alcohol and high carbonic acid; at the same time, the combination of three polypeptides and recombinant collagen treated with liposomes allows the repair, firming and anti-wrinkle effects of the hand cream to have a synergistic effect.

Description

Technical Field

[0001] The invention belongs to the technical field of hand creams, and in particular relates to a multifunctional hand cream and a preparation method thereof. Background Art

[0002] The skin of the hands is the most exposed part besides the facial skin, so there is a saying: the hands are a woman's second face. Therefore, more and more beauty lovers pay attention to the care of the skin of the hands. At present, most of the focus of hand creams on the market is on moisturizing and nourishing. The slightly better ones will increase the soothing and repairing effects, but in fact, the demand for anti-wrinkle of hand skin is also becoming more and more important. After all, a pair of smooth and delicate hands makes people look younger. However, there is a major difference between hand care and facial care. People's hands need to do a lot of things every day and touch a lot of things. It is inevitable that they will come into contact with water for various reasons, which makes the hand cream stay on the hands less durable than on the face, which also leads to the repair, firming and anti-wrinkle effect of the hand cream on the hands. The effect is not ideal. In response to this problem, the current solution may be more inclined to rely on the diligence of the user to reapply the hand cream in time every day, but this increases the cumbersomeness and cost of use.

[0003] Therefore, there is an urgent need to design a waterproof hand cream with repairing, firming and anti-wrinkle effects. By increasing the waterproof performance of the hand cream, the residence time of the hand cream on the hands can be prolonged, so as to enhance the repairing, firming and anti-wrinkle care effects of the hand cream. Summary of the invention

[0004] Therefore, the technical problem to be solved by the present invention is to overcome the problem that the care effect of hand cream in the prior art is not ideal.

[0005] In order to solve the above technical problems, the present invention provides a multifunctional hand cream and a preparation method thereof, which increases the waterproof performance of the hand cream by using high-carbon alcohol and high-carbonic acid, and reduces the defects of weakened repairing, firming and anti-wrinkle effects caused by repeated washing; at the same time, through the combination of three polypeptides with different mechanisms and recombinant collagen treated with liposomes, the repairing, firming and anti-wrinkle effects of the hand cream have a synergistic effect.

[0006] The first object of the present invention is to provide a multifunctional hand cream, which is composed of the following raw materials by weight: 0.1-1 parts of recombinant collagen, 0.1-1 parts of Centella asiatica extract, 0.05-0.2 parts of lactobacillus / soy milk fermentation, 0.05-0.2 parts of peach resin extract, 10.0001-0.001 parts of palmitoyl tripeptide, 70.00005-0.0005 parts of palmitoyl tetrapeptide, 80.0005-0.005 parts of acetyl hexapeptide, 58-92 parts of aqueous phase, 7.55-36.3 parts of oil phase and 1.07-5.2 parts of auxiliary materials; the recombinant collagen is liposome-treated recombinant collagen.

[0007] In one embodiment of the present invention, the aqueous phase is composed of the following raw materials by weight: 4-8 parts of glycerol, 2-6 parts of 1,3-butylene glycol, 0.1-0.5 parts of xanthan gum, 0.01-0.3 parts of sodium hyaluronate, 0.1-0.5 parts of hydrogenated lecithin, 0.1-0.5 parts of allantoin, 0.3-0.6 parts of carbomer, 0.02-0.1 parts of disodium EDTA and 55-80 parts of water.

[0008] In one embodiment of the present invention, the preparation of the aqueous phase comprises the following steps:

[0009] S1. Stir glycerin, xanthan gum and sodium hyaluronate to obtain a dispersion;

[0010] S2. After water, 1,3-butylene glycol and carbomer are stirred evenly, hydrogenated lecithin, allantoin, disodium EDTA and the dispersion described in S1 are added, and the mixture is heated to 80° C.-85° C. and stirred evenly to obtain the aqueous phase.

[0011] In one embodiment of the present invention, the oil phase is composed of the following raw materials by weight: 1-5 parts of isononyl isononanoate, 1-5 parts of isododecane, 1-5 parts of shea butter, 0.5-3 parts of ethylhexyl palmitate, 0.5-2.5 parts of C20-C40 alcohol, 0.5-2.5 parts of C20-C40 acid, 0.5-2 parts of glyceryl stearate, 0.5-2 parts of PEG-100 stearate, 0.05-0.3 parts of tocopheryl acetate, 1-5 parts of cetearyl alcohol and 1-4 parts of polydimethylsiloxane.

[0012] In one embodiment of the present invention, the preparation of the oil phase comprises the following steps:

[0013] Isononyl isononanoate, isododecane, shea butter, ethylhexyl palmitate, C20-C40 alcohol, C20-C40 acid, glyceryl stearate, PEG-100 stearate, tocopheryl acetate, cetearyl alcohol and polydimethylsiloxane are heated to 80° C.-85° C. and stirred evenly to obtain the oil phase.

[0014] In one embodiment of the present invention, the auxiliary material is composed of the following raw materials in parts by weight: 0.3-2 parts of triethanolamine, 0.5-2 parts of 1,2-hexanediol, 0.1-0.3 parts of caprylyl glycol, 0.1-0.5 parts of caprylhydroxamic acid and 0.05-0.3 parts of fragrance.

[0015] In one embodiment of the present invention, the fragrance is selected from essences and / or essential oils.

[0016] The second object of the present invention is to provide a method for preparing the multifunctional hand cream, comprising the following steps:

[0017] S1, adding the oil phase to the water phase, and then adding 70%-90% of triethanolamine, and obtaining a first mixed material by homogenization and defoaming;

[0018] S2, cooling the first mixed material described in S1 to 55° C.-60° C., adding 1,2-hexanediol, caprylyl glycol, and caprylhydroxamic acid, and stirring evenly to obtain a second mixed material;

[0019] S3, cooling the second mixture described in S2 to 40°C-45°C, adding fragrance, recombinant collagen, Centella asiatica extract, lactobacillus / soy milk fermentation, peach resin extract, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7 and acetyl hexapeptide-8, and stirring evenly to obtain a third mixture;

[0020] S4. Add the remaining amount of triethanolamine to the third mixed material described in S3, adjust the pH to 6.0-7.5, and obtain the multifunctional hand cream.

[0021] In one embodiment of the present invention, in S1, the homogenizing speed is 4800 rpm-5200 rpm, and the time is 4 min-6 min.

[0022] In one embodiment of the present invention, in S1, the defoaming temperature is 80°C-85°C, and the time is 10min-20min.

[0023] The technical solution of the present invention has the following advantages over the prior art:

[0024] (1) The recombinant collagen used in the multifunctional hand cream of the present invention is recombinant collagen treated with liposomes. The main component of liposomes is phospholipids, which are bilayer microvesicles with a similar biological membrane structure. They can fuse with cell membranes and deliver active substances into cells. At the same time, liposomes can also protect the biological activity of active substances, delay release, and improve stability. Therefore, recombinant collagen treated with liposomes can be more efficiently absorbed by the skin, achieving better skin barrier repair, wrinkle improvement, and skin smoothing effects.

[0025] (2) The multifunctional hand cream described in the present invention is compounded with palmitoyl tripeptide-1, palmitoyl tetrapeptide-7 and acetyl hexapeptide-8. Palmitoyl tripeptide-1 is a signaling peptide that increases skin firmness and reduces wrinkles by promoting the synthesis of collagen and glucosamine in fibroblasts; palmitoyl tetrapeptide-7 is an anti-wrinkle peptide that achieves a firming effect on the skin by promoting blood circulation and reducing the pro-inflammatory factor IL-6; acetyl hexapeptide-8 is a neurotransmitter inhibitory peptide that competes for the position of SNAP-25 in the complex SNARE, thereby affecting the formation of SNARE, making the muscles unable to accept neurotransmitters, and limiting muscle contraction, ultimately reducing the formation of wrinkles. The three peptides work synergistically from different dimensions to achieve the effect of increasing the elasticity and firmness of the skin and fading fine lines.

[0026] (3) The multifunctional hand cream of the present invention is compounded with liposome-treated recombinant collagen and palmitoyl tripeptide-1, which promotes collagen production internally and supplements collagen externally, thereby achieving a synergistic effect of increasing skin elasticity and repairing the barrier.

[0027] (4) The multifunctional hand cream of the present invention forms a breathable oil film through high carbon alcohol and high carbonic acid, so that the hand cream has good waterproof performance, which can effectively reduce the loss of hand material during hand washing, prolong the residence time of the hand cream on the hands, and thus enhance the repair and anti-wrinkle effect of the hand cream. It has both waterproof performance and breathability, and will not feel greasy or uncomfortable when used. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] In order to make the content of the present invention more clearly understood, the present invention is further described in detail below according to specific embodiments of the present invention in conjunction with the accompanying drawings, wherein:

[0029] Figure 1 This is a numerical diagram of the stratum corneum water content in Test Example 1 of the present invention;

[0030] Figure 2 This is a numerical diagram of transepidermal water loss in Test Example 1 of the present invention;

[0031] Figure 3 This is a numerical diagram of skin elasticity of Test Example 1 of the present invention;

[0032] Figure 4 This is a numerical diagram of skin smoothness SEsm of Test Example 1 of the present invention;

[0033] Figure 5 This is the skin wrinkle SEw numerical diagram of Test Example 1 of the present invention;

[0034] Figure 6 It is a waterproof performance test diagram of Test Example 3 of the present invention; wherein (A) is before flushing, and (B) is after flushing. DETAILED DESCRIPTION

[0035] The present invention is further described below in conjunction with specific embodiments so that those skilled in the art can better understand the present invention and implement it. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. It should be understood that the specific embodiments are only used to explain the present invention, but the embodiments are not intended to limit the present invention.

[0036] In the present invention, unless otherwise explained, technical and scientific terms used in the present invention have the same meanings as commonly understood by those skilled in the art to which the present invention belongs.

[0037] In the present invention, unless otherwise stated, the term "and / or" used in the present invention includes any and all combinations of one or more of the associated listed items.

[0038] In the present invention, unless otherwise stated, the experimental methods used in the embodiments of the present invention are conventional methods unless otherwise stated, and the materials, reagents, etc. used are all commercially available unless otherwise stated.

[0039] In the present invention, unless otherwise specified, the liposome-treated recombinant collagen used in the examples of the present invention was purchased from Zhejiang Zhuji Juyuan Biotechnology Co., Ltd., and the product number is Beikeli transdermal recombinant collagen (LLA).

[0040] In the present invention, unless otherwise specified, the Centella asiatica extract used in the examples of the present invention was purchased from Shanghai Jiakai Biotechnology Co., Ltd., with the product number being Redumatte ASC-II.

[0041] In the present invention, unless otherwise specified, the lactobacillus / soy milk fermentation product used in the embodiments of the present invention was purchased from Xianting (Guangzhou) Trading Co., Ltd., with the product number OPTIMEALTH 10W.

[0042] In the present invention, unless otherwise specified, the peach resin extract used in the examples of the present invention was purchased from Shanghai Jiakai Biotechnology Co., Ltd., and the product number is Immedeline PG.

[0043] In the present invention, unless otherwise specified, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7 used in the examples of the present invention were purchased from SEDERMA, SAS with the product number MATRIXYL 3000.

[0044] In the present invention, unless otherwise specified, acetyl hexapeptide-8 used in the examples of the present invention was purchased from LIPOTEC SAU with the product number ARGIRELINE peptide solution C.

[0045] Example 1

[0046] The raw material components and their weight parts of the multifunctional hand cream of this embodiment are as follows:

[0047] The aqueous phase is composed of the following raw materials by weight: 6 parts of glycerol, 4 parts of 1,3-butylene glycol, 0.2 parts of xanthan gum, 0.1 parts of sodium hyaluronate, 0.3 parts of hydrogenated lecithin, 0.15 parts of allantoin, 0.4 parts of carbomer, 0.05 parts of disodium EDTA, and 63 parts of deionized water;

[0048] The oil phase is composed of the following raw materials by weight: 3 parts of isononyl isononanoate, 4 parts of isododecane, 3 parts of shea butter, 2 parts of ethylhexyl palmitate, 1.5 parts of C20-C40 alcohol, 1.5 parts of C20-C40 acid, 1 part of glyceryl stearate, 1 part of PEG-100 stearate, 0.15 parts of tocopheryl acetate, 3 parts of cetearyl alcohol, and 2 parts of polydimethicone;

[0049] The auxiliary materials are composed of the following raw materials by weight: 1.2 parts of triethanolamine, 1 part of 1,2-hexanediol, 0.2 parts of caprylyl glycol, 0.3 parts of caprylhydroxamic acid, and 0.15 parts of flavor;

[0050] The effective ingredients are composed of the following ingredients by weight: 0.3 parts of liposome-treated recombinant collagen, 0.5 parts of Centella asiatica extract, 0.1 parts of lactobacillus / soy milk fermentation product, 0.1 parts of peach resin extract, 10.0002 parts of palmitoyl tripeptide, 70.0001 parts of palmitoyl tetrapeptide, and 80.001 parts of acetyl hexapeptide;

[0051] Its preparation specifically comprises the following steps:

[0052] S1. Evenly mix glycerin, xanthan gum and sodium hyaluronate to obtain a dispersion;

[0053] S2, add deionized water, 1,3-butylene glycol, and carbomer into a container, quickly stir and disperse them evenly, then add hydrogenated lecithin, allantoin, disodium EDTA, and dispersion liquid, heat to 80-85° C. and stir evenly to obtain an aqueous phase;

[0054] S3, add isononyl isononanoate, isododecane, shea butter, ethylhexyl palmitate, C20-C40 alcohol, C20-C40 acid, glyceryl stearate, PEG-100 stearate, tocopheryl acetate, cetearyl alcohol, and polydimethylsiloxane into a container, heat to 80-85° C. and stir evenly to obtain an oil phase;

[0055] S4, adding the oil phase to the water phase, adding 80% of triethanolamine, homogenizing with a homogenizer at 5000 rpm for 5 min, and then placing in a water bath at 80° C. for 15 min to defoam, to obtain a first mixture;

[0056] S5, cooling the first mixture to 55° C., adding 1,2-hexanediol, caprylyl glycol and caprylhydroxamic acid, and stirring evenly to obtain a second mixture;

[0057] S6, cooling the second mixture to 40° C., adding essence and recombinant collagen, Centella asiatica extract, lactobacillus / soy milk fermentation product, peach resin extract, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7 and acetyl hexapeptide-8, and stirring evenly to obtain a third mixture;

[0058] S7. Add the remaining 20% ​​of triethanolamine to the third mixture, adjust the pH to 6.7 (10% aqueous solution, 25° C.), and obtain a multifunctional hand cream.

[0059] Comparative Example 1

[0060] The same as Example 1, except that the C20-C40 alcohol is replaced by cetearyl alcohol, and the C20-C40 acid is replaced by stearic acid. The raw material components and their weight parts are as follows:

[0061] The aqueous phase is composed of the following raw materials by weight: 6 parts of glycerol, 4 parts of 1,3-butylene glycol, 0.2 parts of xanthan gum, 0.1 parts of sodium hyaluronate, 0.3 parts of hydrogenated lecithin, 0.15 parts of allantoin, 0.4 parts of carbomer, 0.05 parts of disodium EDTA, and 63 parts of deionized water;

[0062] The oil phase is composed of the following raw materials by weight: 3 parts of isononyl isononanoate, 4 parts of isododecane, 3 parts of shea butter, 2 parts of ethylhexyl palmitate, 1.5 parts of stearic acid, 1 part of glyceryl stearate, 1 part of PEG-100 stearate, 0.15 parts of tocopheryl acetate, 4.5 parts of cetearyl alcohol, and 2 parts of polydimethylsiloxane;

[0063] The auxiliary materials are composed of the following raw materials by weight: 1.2 parts of triethanolamine, 1 part of 1,2-hexanediol, 0.2 parts of caprylyl glycol, 0.3 parts of caprylhydroxamic acid, and 0.15 parts of flavor;

[0064] The effective ingredients are composed of the following ingredients by weight: 0.3 parts of liposome-treated recombinant collagen, 0.5 parts of Centella asiatica extract, 0.1 parts of lactobacillus / soy milk fermentation product, 0.1 parts of peach resin extract, 10.0002 parts of palmitoyl tripeptide, 70.0001 parts of palmitoyl tetrapeptide, and 80.001 parts of acetyl hexapeptide.

[0065] Comparative Example 2

[0066] The method is basically the same as Example 1, except that the liposome-treated recombinant collagen is replaced with liposome-untreated recombinant collagen. The raw material components and their weight parts are as follows:

[0067] Aqueous phase: 6 parts of glycerin, 4 parts of 1,3-butylene glycol, 0.2 parts of xanthan gum, 0.1 parts of sodium hyaluronate, 0.3 parts of hydrogenated lecithin, 0.15 parts of allantoin, 0.4 parts of carbomer, 0.05 parts of disodium EDTA, 63 parts of deionized water;

[0068] Oil phase: 3 parts of isononyl isononanoate, 4 parts of isododecane, 3 parts of shea butter, 2 parts of ethylhexyl palmitate, 1.5 parts of C20-C40 alcohol, 1.5 parts of C20-C40 acid, 1 part of glyceryl stearate, 1 part of PEG-100 stearate, 0.15 parts of tocopheryl acetate, 3 parts of cetearyl alcohol, 2 parts of dimethicone;

[0069] Excipients: 1.2 parts of triethanolamine, 1 part of 1,2-hexanediol, 0.2 parts of caprylyl glycol, 0.3 parts of caprylhydroxamic acid, and 0.15 parts of flavor;

[0070] Functional ingredients: 0.3 parts of recombinant collagen, 0.5 parts of Centella asiatica extract, 0.1 parts of lactobacillus / soy milk fermentation product, 0.1 parts of peach resin extract, 10.0002 parts of palmitoyl tripeptide, 70.0001 parts of palmitoyl tetrapeptide, and 80.001 parts of acetyl hexapeptide.

[0071] Comparative Example 3

[0072] The method is basically the same as Example 1, except that acetyl hexapeptide-8 is not added. The raw material components and their weight parts are as follows:

[0073] Aqueous phase: 6 parts of glycerin, 4 parts of 1,3-butylene glycol, 0.2 parts of xanthan gum, 0.1 parts of sodium hyaluronate, 0.3 parts of hydrogenated lecithin, 0.15 parts of allantoin, 0.4 parts of carbomer, 0.05 parts of disodium EDTA, 63 parts of deionized water;

[0074] Oil phase: 3 parts of isononyl isononanoate, 4 parts of isododecane, 3 parts of shea butter, 2 parts of ethylhexyl palmitate, 1.5 parts of C20-C40 alcohol, 1.5 parts of C20-C40 acid, 1 part of glyceryl stearate, 1 part of PEG-100 stearate, 0.15 parts of tocopheryl acetate, 3 parts of cetearyl alcohol, 2 parts of dimethicone;

[0075] Excipients: 1.2 parts of triethanolamine, 1 part of 1,2-hexanediol, 0.2 parts of caprylyl glycol, 0.3 parts of caprylhydroxamic acid, and 0.15 parts of flavor;

[0076] Functional ingredients: 0.3 parts of liposome-treated recombinant collagen, 0.5 parts of Centella asiatica extract, 0.1 parts of lactobacillus / soy milk fermentation product, 0.1 parts of peach resin extract, 0.0002 parts of palmitoyl tripeptide-1, and 0.0001 parts of palmitoyl tetrapeptide-7.

[0077] Test Example 1

[0078] 33 volunteers were screened, and the stratum corneum water content, transepidermal water loss, skin elasticity, skin smoothness SEsm and skin wrinkles SEw on the 0th day, the 14th day and the 28th day using the multifunctional hand cream prepared using Example 1 and Comparative Examples 1-3 were tested respectively;

[0079] (1) Water content of stratum corneum: The measuring instrument is the stratum corneum moisture content tester MoistureSC; the test is performed 3 times and the average value is taken; the measuring area is the back of the hand; the higher the value, the higher the water content of the stratum corneum of the skin. The specific test results are as follows: Figure 1 At the same time, the growth rate and significant difference of the water content of the stratum corneum of the skin of the four samples after using the product for 14 days and 28 days were calculated respectively ("*" indicates that the measured value is significantly different compared with before use (0.01<P<0.05), and "**" indicates that the measured value is extremely significantly different compared with before use (P≤0.01)). The specific results are shown in Table 1:

[0080] Table 1

[0081]

[0082] from Figure 1 As can be seen from Table 1, after using the hand cream, the moisture content of the stratum corneum in the back of the hand is significantly higher than before use, indicating that the test sample has a moisturizing effect. After 14 days and 28 days of use, the moisture content of the stratum corneum on the back of the hand in Example 1 is significantly higher than that in Comparative Example 1, indicating that the hand cream has a significant moisturizing effect after adding C20-C40 alcohol and C20-C40 acid; the moisture content of the stratum corneum on the back of the hand in Example 1 is also significantly higher than that in Comparative Example 2, indicating that the hand cream has a significant moisturizing effect after adding liposome reconstituted collagen; the moisture content of the stratum corneum on the back of the hand in Example 1 is slightly higher than that in Comparative Example 3, indicating that the hand cream has a certain moisturizing effect after adding acetyl hexapeptide-8.

[0083] (2) Transepidermal water loss (g / (h·m 2 )) The measuring instrument is TewameterTM 300, the test is repeated 3 times and the average value is taken. The measuring area is the back of the hand. The lower the value, the less the transepidermal water loss. The specific test results are as follows: Figure 2 At the same time, the improvement rate and significant difference of transepidermal water loss of the four samples after using the product for 14 days and 28 days were calculated respectively. The specific results are shown in Table 2:

[0084] Table 2

[0085]

[0086] from Figure 2 As can be seen from Table 2, after using the hand cream, the TEWL value of the back of the hand area is significantly lower than before use, indicating that the test product has the effect of repairing the skin barrier. After 14 days and 28 days of use, the TEWL value of the back of the hand in Example 1 is significantly lower than that in Comparative Example 1, indicating that the hand cream has a significant effect of repairing the skin barrier after adding C20-C40 alcohol and C20-C40 acid; the water content of the TEWL value in Example 1 is also significantly lower than that in Comparative Example 2, indicating that the hand cream has a significant effect of repairing the skin barrier after adding liposome recombinant collagen; the TEWL value of the back of the hand in Example 1 is slightly higher than that in Comparative Example 3, indicating that the hand cream has a certain effect of repairing the skin barrier after adding acetyl hexapeptide-8.

[0087] (3) Skin elasticity (N / m): The measuring instrument is the ElastiMeter skin elasticity measuring instrument; the test is repeated three times and the average value is taken; the measurement area is the back of the hand; the higher the value, the more elastic and firm the skin is. The specific test results are as follows: Figure 3 At the same time, the skin elasticity growth rate and significant difference of the four samples after using the product for 14 days and 28 days were calculated respectively. The specific results are shown in Table 3:

[0088] Table 3

[0089]

[0090] from Figure 3 As can be seen from Table 3, after using the hand cream, the skin elasticity value of the back of the hand area is significantly higher than before use, indicating that the test product has a skin tightening effect. After 14 days and 28 days of use, the skin elasticity value of the back of the hand of Example 1 is significantly higher than that of Comparative Example 1, indicating that the hand cream has a significant skin tightening effect after adding C20-C40 alcohol and C20-C40 acid; the skin elasticity value of the back of the hand of Example 1 is also significantly higher than that of Comparative Example 2, indicating that the hand cream has a significant skin tightening effect after adding liposome reconstituted collagen; the skin elasticity value of the back of the hand of Example 1 is slightly higher than that of Comparative Example 3, indicating that the hand cream has a certain skin tightening effect after adding acetyl hexapeptide-8.

[0091] (4) Skin smoothness SEsm value: The measuring instrument is the skin surface texture test system VisioScan VC20plus; the test is performed 3 times and the average value is taken; the measurement area is the back of the hand; the smaller the value, the smoother the skin. The specific test results are as follows: Figure 4At the same time, the improvement rate and significant difference of the transcutaneous smoothness SEsm value of the four samples after using the product for 14 days and 28 days were calculated respectively. The specific results are shown in Table 4:

[0092] Table 4

[0093]

[0094] from Figure 4 As can be seen from Table 4, after using the hand cream, the SEsm value of the skin smoothness of the back of the hand area is significantly lower than that before use, indicating that the test product has a smooth skin effect. After 14 days and 28 days of use, the SEsm value of the skin smoothness of the back of the hand of Example 1 is significantly lower than that of Comparative Example 1, indicating that the hand cream has a significant effect of smoothing the skin after adding C20-C40 alcohol and C20-C40 acid; the SEsm value of the skin smoothness of the back of the hand of Example 1 is also significantly lower than that of Comparative Example 2, indicating that the hand cream has a significant effect of smoothing the skin after adding liposome recombinant collagen; the SEsm value of the skin smoothness of the back of the hand of Example 1 is also significantly lower than that of Comparative Example 3, indicating that the hand cream has a significant effect of smoothing the skin after adding acetyl hexapeptide-8.

[0095] (5) Skin wrinkle SEw value: The measuring instrument is the skin surface texture test system VisioScan VC20plus; the test is performed 3 times and the average value is taken; the measurement area is the back of the hand; the smaller the value, the fewer the skin wrinkles. The specific test results are as follows: Figure 5 At the same time, the improvement rate and significant difference of SEw value of skin wrinkles of the four samples after using the product for 14 days and 28 days were calculated respectively. The specific results are shown in Table 5:

[0096] Table 5

[0097]

[0098]

[0099] from Figure 5 As can be seen from Table 5, after using the hand cream, the SEw value of the skin wrinkles in the back of the hand area is significantly lower than before use, indicating that the test product has the effect of reducing wrinkles. The SEw value of the skin wrinkles on the back of the hand in Example 1 is significantly lower than that in Comparative Example 1, indicating that the hand cream has a significant effect of reducing skin wrinkles after adding C20-C40 alcohol and C20-C40 acid; the SEw value of the skin wrinkles on the back of the hand in Example 1 is slightly lower than that in Comparative Example 2, indicating that the hand cream has a certain effect of reducing wrinkles after adding liposome recombinant collagen; the SEw value of the skin wrinkles on the back of the hand in Example 1 is significantly lower than that in Comparative Example 3, indicating that the hand cream has a significant effect of reducing wrinkles after adding acetyl hexapeptide-8.

[0100] Test Example 2

[0101] 33 volunteers were asked to conduct a satisfaction survey on the irritation, absorption speed, breathability and other indicators based on their subjective feelings during use. The sensory evaluation standards are shown in Table 6. When calculating the satisfaction, scores ≥ 4 points were recorded in the statistics. Finally, the evaluation results of each indicator were converted into a percentage system. The specific sensory evaluation results are shown in Table 7:

[0102] Table 6 Sensory evaluation table

[0103]

[0104] Table 7 Sensory evaluation results

[0105]

[0106]

[0107] It can be seen from Table 7 that the volunteers' experience of using Example 1 is significantly better than that of Comparative Example 1, indicating that the hand cream prepared in Example 1 has excellent repairing, firming, anti-wrinkle and waterproof effects, and does not bring a burden to the skin on the basis of increased waterproofness.

[0108] Test Example 3

[0109] In order to visually see the waterproof performance of the sample, the multifunctional hand cream needs to be colored. The specific steps are as follows: when preparing the samples of Example 1 and Comparative Example 1, add the same content (1%) of iron red powder to the oil phase components of Example 1 and Comparative Example 1 respectively, and mix them finely. The other steps remain unchanged to obtain the colored samples of Example 1 and Comparative Example 1. Apply the same amount (0.3g) of the sample on the back of the left and right hands respectively, apply it evenly, let it stand for 10 minutes, and after the sample is absorbed and dried, rinse it with the same water flow rate for 1 minute, and observe the degree of pigment residue before and after rinsing. The results are as follows: Figure 6 As shown. Figure 6 It can be seen that the hand cream prepared in Example 1 has an obvious waterproof effect compared with the hand cream prepared in Comparative Example 1.

[0110] Obviously, the above embodiments are merely examples for clear explanation and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived from these are still within the protection scope of the invention.

Claims

1. A multifunctional hand cream, characterized in that: The multifunctional hand cream is composed of the following raw materials by weight: 0.1-1 parts of recombinant collagen, 0.1-1 parts of Centella asiatica extract, 0.05-0.2 parts of lactobacillus / soy milk fermentation, 0.05-0.2 parts of peach resin extract, 10.0001-0.001 parts of palmitoyl tripeptide, 70.00005-0.0005 parts of palmitoyl tetrapeptide, 80.0005-0.005 parts of acetyl hexapeptide, 58-92 parts of aqueous phase, 7.55-36.3 parts of oil phase and 1.07-5.2 parts of auxiliary materials; the recombinant collagen is liposome-treated recombinant collagen.

2. The multifunctional hand cream according to claim 1, characterized in that: The aqueous phase is composed of the following raw materials by weight: 4-8 parts of glycerol, 2-6 parts of 1,3-butylene glycol, 0.1-0.5 parts of xanthan gum, 0.01-0.3 parts of sodium hyaluronate, 0.1-0.5 parts of hydrogenated lecithin, 0.1-0.5 parts of allantoin, 0.3-0.6 parts of carbomer, 0.02-0.1 parts of disodium EDTA and 55-80 parts of water.

3. The multifunctional hand cream according to claim 2, characterized in that: The preparation of the aqueous phase comprises the following steps: S1. Stir glycerin, xanthan gum and sodium hyaluronate to obtain a dispersion; S2. After water, 1,3-butylene glycol and carbomer are stirred evenly, hydrogenated lecithin, allantoin, disodium EDTA and the dispersion described in S1 are added, and the mixture is heated to 80° C.-85° C. and stirred evenly to obtain the aqueous phase.

4. The multifunctional hand cream according to claim 1, characterized in that: The oil phase is composed of the following raw materials by weight: 1-5 parts of isononyl isononanoate, 1-5 parts of isododecane, 1-5 parts of shea butter, 0.5-3 parts of ethylhexyl palmitate, 0.5-2.5 parts of C20-C40 alcohol, 0.5-2.5 parts of C20-C40 acid, 0.5-2 parts of glyceryl stearate, 0.5-2 parts of PEG-100 stearate, 0.05-0.3 parts of tocopheryl acetate, 1-5 parts of cetearyl alcohol and 1-4 parts of polydimethylsiloxane.

5. The multifunctional hand cream according to claim 4, characterized in that: The preparation of the oil phase comprises the following steps: Isononyl isononanoate, isododecane, shea butter, ethylhexyl palmitate, C20-C40 alcohol, C20-C40 acid, glyceryl stearate, PEG-100 stearate, tocopheryl acetate, cetearyl alcohol and polydimethylsiloxane are heated to 80° C.-85° C. and stirred evenly to obtain the oil phase.

6. The multifunctional hand cream according to claim 1, characterized in that: The auxiliary material is composed of the following raw materials by weight: 0.3-2 parts of triethanolamine, 0.5-2 parts of 1,2-hexanediol, 0.1-0.3 parts of caprylyl glycol, 0.1-0.5 parts of caprylhydroxamic acid and 0.05-0.3 parts of aromatic agent.

7. The multifunctional hand cream according to claim 6, characterized in that: The fragrance is selected from essences and / or essential oils.

8. The method for preparing the multifunctional hand cream according to any one of claims 1 to 7, characterized in that: The following steps are involved: S1, adding the oil phase to the water phase, and then adding 70%-90% of triethanolamine, and obtaining a first mixed material by homogenization and defoaming; S2, cooling the first mixed material described in S1 to 55° C.-60° C., adding 1,2-hexanediol, caprylyl glycol, and caprylhydroxamic acid, and stirring evenly to obtain a second mixed material; S3, cooling the second mixture described in S2 to 40°C-45°C, adding fragrance, recombinant collagen, Centella asiatica extract, lactobacillus / soy milk fermentation, peach resin extract, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7 and acetyl hexapeptide-8, and stirring evenly to obtain a third mixture; S4. Add the remaining amount of triethanolamine to the third mixed material described in S3, adjust the pH to 6.0-7.5, and obtain the multifunctional hand cream.

9. The method for preparing the multifunctional hand cream according to claim 8, characterized in that: In S1, the homogenization speed is 4800 rpm-5200 rpm, and the time is 4 min-6 min.

10. The method for preparing the multifunctional hand cream according to claim 8, characterized in that: In S1, the defoaming temperature is 80°C-85°C, and the time is 10min-20min.

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