Ganoderma lucidum spore powder composition capable of reducing blood fat and preparation method of ganoderma lucidum spore powder composition

Abstract

The invention provides a blood fat reducing ganoderma lucidum spore powder composition and a preparation method thereof. The composition comprises ganoderma lucidum spore powder, a salvia miltiorrhiza extract, a fructus forsythiae extract and a licorice extract. In the composition, the ganoderma lucidum spore powder and the traditional Chinese medicine extract are reasonably utilized, so that the obtained composition has an excellent lipid-lowering effect; and the composition has the advantage of few adverse reactions.

Description

Technical Field

[0001] The invention relates to the technical field of ganoderma lucidum spore powder application, and in particular to a ganoderma lucidum spore powder composition for lowering blood lipids and a preparation method thereof. Background Art

[0002] Ganoderma spores are tiny spores derived from Ganoderma lucidum, which are released after the Ganoderma lucidum grows and matures. Ganoderma spores contain terpenoids, proteins, amino acids, polysaccharides and other substances, which give them excellent biological activities, such as enhancing immunity and anti-fatigue. As research has found, Ganoderma spores also have anti-inflammatory, antioxidant, and immune-regulating properties, which has increased their demand. Since the outer wall of Ganoderma spores is hard and difficult to be absorbed and utilized, Ganoderma spore powder is prepared by breaking the wall to improve the absorption and utilization rate of Ganoderma spores.

[0003] Blood lipids mainly include cholesterol, triglycerides, phospholipids and free fatty acids. When the blood lipid level is abnormal, it is easy to cause health problems. Currently, the treatment of blood lipids is mainly based on Western medicine, such as statins. Although this type of drug can have a good effect, it may have more adverse reactions, such as muscle pain or weakness, increased liver enzymes, and increased risk of diabetes.

[0004] Therefore, providing a safe and effective lipid-lowering composition is of great significance to the industry. Summary of the invention

[0005] In view of this, the present invention provides a blood lipid-lowering ganoderma spore powder composition and a preparation method thereof, wherein the composition comprises ganoderma spore powder, salvia miltiorrhiza extract, forsythia suspensa extract and liquorice extract. In the composition, ganoderma spore powder and Chinese herbal medicine extract are reasonably utilized, so that the obtained composition has an excellent blood lipid-lowering effect; and the composition has the advantage of less adverse reactions.

[0006] The technical solution of the present invention is as follows: A blood lipid-lowering Ganoderma lucidum spore powder composition comprises the following components in parts by weight: 55-60 parts of Ganoderma lucidum spore powder, 15-20 parts of Salvia miltiorrhiza extract, 10-15 parts of Forsythia suspensa extract, and 5-20 parts of Licorice extract; Ganoderma lucidum spore powder, particle size is between 0.1-0.5μm.

[0007] Preferably, the lipid-lowering Ganoderma lucidum spore powder composition comprises the following components in parts by weight: 57 parts of ganoderma lucidum spore powder, 18 parts of salvia miltiorrhiza extract, 11 parts of forsythia suspensa extract and 14 parts of liquorice extract.

[0008] Preferably, the preparation method of the Salvia miltiorrhiza extract is as follows: Mix the powder of Danshen with water in a weight ratio of 1:2-4, soak for 3-5 hours, heat under reflux for 1-1.5 hours, and collect the extract A; The pH of the extract A is adjusted to 4.2±0.1, and then cellulase and pectinase are added, and enzymolysis is performed at 55±0.1°C for 3.5-4h, and the enzymes are inactivated to obtain an enzymolysis solution; The enzymatic hydrolysate was filtered and the filtrate A was collected; the filtrate A was concentrated under reduced pressure to a relative density of 1.9-2.0 (50°C), and then ethanol was added and allowed to stand, and the supernatant was taken and concentrated under reduced pressure to a thick paste, which was then dried and crushed.

[0009] Preferably, the particle size of the salvia miltiorrhiza powder is 1-3 mm; the weight ratio of the salvia miltiorrhiza powder to water is 1:3; and the reflux extraction is performed twice.

[0010] Preferably, the added amount of cellulase is 2.5-3.3u / g, and the added amount of pectinase is 3.8-4.2u / g.

[0011] Preferably, after cooling, ethanol is added until the alcohol content is 75%.

[0012] Preferably, the Forsythia suspensa extract is prepared as follows: Mix the Forsythia suspensa powder and water in a weight ratio of 1:3-5, decoct for 3 times, each time for 1.5 hours, and collect the extract B; The extract B was concentrated under reduced pressure to a relative density of 1.15-1.18 (room temperature); after cooling, 2-3 times of ethanol was added, allowed to stand, filtered, and the filtrate B was collected; the filtrate B was concentrated under reduced pressure to a thick paste, dried, and crushed.

[0013] Preferably, the liquorice extract is prepared by the following method: Slice licorice and mix with water in a weight ratio of 1:5-7, decoct for 3 times with stirring, each time for 2-3 hours, and collect extract C; The extract C was concentrated under reduced pressure to a thick paste, dried and crushed.

[0014] Preferably, the stirring speed is 30-50 r / min.

[0015] The preparation method of the above-mentioned blood lipid-lowering Ganoderma lucidum spore powder composition is as follows: (1) Ganoderma lucidum spore powder, salvia miltiorrhiza extract, forsythia suspensa extract and liquorice extract are prepared according to the ratio; (2) Place all components in a mixer and mix them evenly to obtain a composite material.

[0016] Compared with the prior art, the beneficial effects of the present invention are: In the present invention, a method of using Chinese medicine in combination with Ganoderma lucidum spore powder is adopted to improve the absorption and utilization of active substances in the spore powder, and effectively reduce the cholesterol content and triglyceride content in the blood; and the composition has the advantage of fewer adverse reactions compared with Western medicine for lowering blood lipids. DETAILED DESCRIPTION

[0017] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0018] Example 1 A blood lipid-lowering Ganoderma lucidum spore powder composition comprises the following components by weight: Ganoderma lucidum spore powder 57g, Salvia miltiorrhiza extract 18g, Forsythia suspensa extract 11g, Licorice extract 14g; Ganoderma lucidum spore powder, particle size between 0.1-0.5μm; Wherein, the preparation method of Salvia miltiorrhiza extract is as follows: The powder of Danshen was mixed with water in a weight ratio of 1:3, soaked for 4 hours, heated to reflux for 1-1.5 hours, refluxed for 2 times, and the extract A was collected; the particle size of the powder of Danshen was 1-3 mm; The pH of the extract A was adjusted to 4.2, and then cellulase and pectinase were added, and enzymolysis was performed at 55±0.1°C for 3.6 hours, and the enzymes were inactivated to obtain an enzymolysis solution; The amount of cellulase added was 2.7u / g, and the amount of pectinase added was 4.0u / g; The enzymatic hydrolysate was filtered and the filtrate A was collected; the filtrate A was concentrated under reduced pressure to a relative density of 1.95 (50°C), cooled, and ethanol was added to an alcohol content of 75%, and allowed to stand for 18 hours, the supernatant was taken, concentrated under reduced pressure to a thick paste, dried, and crushed to a particle size of 0.1-1 μm; Forsythia suspensa extract, the preparation method is as follows: Mix the Forsythia suspensa powder and water in a weight ratio of 1:4, decoct for 3 times, each time for 1.5 hours, and collect the extract B; the particle size of the Forsythia suspensa powder is 2-5 mm; The extract B was concentrated under reduced pressure to a relative density of 1.17 (room temperature); after cooling, 3 times of ethanol was added, allowed to stand, filtered, and the filtrate B was collected; the filtrate B was concentrated under reduced pressure to a thick paste, dried, and crushed to a particle size of 0.1-1 μm; Licorice extract, preparation method is as follows: Slice licorice and mix with water in a weight ratio of 1:6, soak for 5 hours, and then boil for 3 times with stirring, each time for 2.5 hours, and collect extract C; the stirring speed is 40r / min; The extract C was concentrated under reduced pressure to a thick paste, dried, and crushed to a particle size of 0.1-1 μm; The preparation method of the above-mentioned blood lipid-lowering Ganoderma lucidum spore powder composition is as follows: (1) Ganoderma lucidum spore powder, salvia miltiorrhiza extract, forsythia suspensa extract and liquorice extract are prepared according to the ratio; (2) Place all components in a mixer and mix them evenly to obtain a composite material.

[0019] Example 2 A blood lipid-lowering Ganoderma lucidum spore powder composition comprises the following components in parts by weight: Ganoderma lucidum spore powder 55g, Salvia miltiorrhiza extract 15g, Forsythia suspensa extract 10g, Licorice extract 20g; Ganoderma lucidum spore powder, particle size between 0.1-0.5μm; Wherein, the preparation method of Salvia miltiorrhiza extract is as follows: The powder of Danshen was mixed with water in a weight ratio of 1:2, soaked for 5 hours, heated under reflux for 1 hour, and refluxed for 2 times to collect extract A; the particle size of the powder of Danshen was 1-3 mm; The pH of the extract A was adjusted to 4.1, and then cellulase and pectinase were added, and enzymolysis was performed at 55±0.1°C for 4 hours, and the enzymes were inactivated to obtain an enzymolysis solution; The amount of cellulase added was 2.5u / g, and the amount of pectinase added was 3.8u / g; The enzymatic hydrolysate was filtered and the filtrate A was collected; the filtrate A was concentrated under reduced pressure to a relative density of 1.9 (50°C), cooled, and then ethanol was added to an alcohol content of 75%, and the mixture was allowed to stand for 15 hours, the supernatant was taken, concentrated under reduced pressure to a thick paste, dried, and crushed to a particle size of 0.1-1 μm; Forsythia suspensa extract, the preparation method is as follows: Mix the Forsythia suspensa powder and water in a weight ratio of 1:3, decoct for 3 times, each time for 1.5 hours, and collect the extract B; the particle size of the Forsythia suspensa powder is 2-5 mm; The extract B was concentrated under reduced pressure to a relative density of 1.15 (room temperature); after cooling, 2 times ethanol was added, allowed to stand, filtered, and the filtrate B was collected; the filtrate B was concentrated under reduced pressure to a thick paste, dried, and crushed to a particle size of 0.1-1 μm; Licorice extract, preparation method is as follows: Slice licorice and mix with water in a weight ratio of 1:5, decoct for 3 times with stirring, each time for 2 hours, and collect extract C; the stirring speed is 30r / min; The extract C was concentrated under reduced pressure to a thick paste, dried, and crushed to a particle size of 0.1-1 μm; The preparation method of the above-mentioned blood lipid-lowering Ganoderma lucidum spore powder composition is as follows: (1) Ganoderma lucidum spore powder, salvia miltiorrhiza extract, forsythia suspensa extract and liquorice extract are prepared according to the ratio; (2) Place all components in a mixer and mix them evenly to obtain a composite material.

[0020] Example 3 A blood lipid-lowering Ganoderma lucidum spore powder composition comprises the following components in parts by weight: Ganoderma lucidum spore powder 60g, Salvia miltiorrhiza extract 20g, Forsythia suspensa extract 15g, Licorice extract 5g; Ganoderma lucidum spore powder, particle size between 0.1-0.5μm; Wherein, the preparation method of Salvia miltiorrhiza extract is as follows: The powder of Danshen was mixed with water in a weight ratio of 1:4, and after soaking for 3 hours, the mixture was heated under reflux for 1.5 hours, and refluxed for 2 times to collect the extract A; the particle size of the powder of Danshen was 1-3 mm; The pH of the extract A was adjusted to 4.3, and then cellulase and pectinase were added, and enzymolysis was performed at 55±0.1°C for 3.5 hours, and the enzymes were inactivated to obtain an enzymolysis solution; The amount of cellulase added was 3.3u / g, and the amount of pectinase added was 4.2u / g; The enzymatic hydrolysate was filtered and the filtrate A was collected; the filtrate A was concentrated under reduced pressure to a relative density of 2.0 (50°C), cooled, and then ethanol was added to an alcohol content of 75%, and the mixture was allowed to stand for 20 hours, the supernatant was taken, concentrated under reduced pressure to a thick paste, dried, and crushed to a particle size of 0.1-1 μm; Forsythia suspensa extract, the preparation method is as follows: Mix the Forsythia suspensa powder and water in a weight ratio of 1:5, decoct for 3 times, each time for 1.5 hours, and collect the extract B; the particle size of the Forsythia suspensa powder is 2-5 mm; The extract B was concentrated under reduced pressure to a relative density of 1.18 (room temperature); after cooling, 3 times of ethanol was added, allowed to stand, filtered, and the filtrate B was collected; the filtrate B was concentrated under reduced pressure to a thick paste, dried, and crushed to a particle size of 0.1-1 μm; Licorice extract, preparation method is as follows: Slice the licorice root and mix it with water in a weight ratio of 1:7, and boil it for 3 times with stirring, each time for 3 hours, and collect the extract C; the stirring speed is 50r / min; The extract C was concentrated under reduced pressure to a thick paste, dried, and crushed to a particle size of 0.1-1 μm; The preparation method of the above-mentioned blood lipid-lowering Ganoderma lucidum spore powder composition is as follows: (1) Ganoderma lucidum spore powder, salvia miltiorrhiza extract, forsythia suspensa extract and liquorice extract are prepared according to the ratio; (2) Place all components in a mixer and mix them evenly to obtain a composite material.

[0021] Although the present invention has been described in detail by reference to the preferred embodiments, the present invention is not limited thereto. Without departing from the spirit and essence of the present invention, a person of ordinary skill in the art may make various equivalent modifications or substitutions to the embodiments of the present invention, and these modifications or substitutions shall be within the scope of the present invention. Any person of ordinary skill in the art may easily think of changes or substitutions within the technical scope disclosed by the present invention, and these shall be within the scope of protection of the present invention. Therefore, the scope of protection of the present invention shall be subject to the scope of protection of the claims.

Claims

1. A blood lipid lowering Ganoderma lucidum spore powder composition, characterized in that: The composition comprises the following components in parts by weight: 55-60 parts of Ganoderma lucidum spore powder, 15-20 parts of Salvia miltiorrhiza extract, 10-15 parts of Forsythia suspensa extract, and 5-20 parts of Licorice extract; Ganoderma lucidum spore powder, particle size is between 0.1-0.5μm.

2. The lipid-lowering Ganoderma lucidum spore powder composition according to claim 1, characterized in that: The blood lipid-lowering Ganoderma lucidum spore powder composition comprises the following components in parts by weight: 57 parts of ganoderma lucidum spore powder, 18 parts of salvia miltiorrhiza extract, 11 parts of forsythia suspensa extract and 14 parts of liquorice extract.

3. The lipid-lowering Ganoderma lucidum spore powder composition according to claim 1, characterized in that: Salvia miltiorrhiza extract, the preparation method is as follows: Mix the powder of Danshen with water in a weight ratio of 1:2-4, soak for 3-5 hours, heat under reflux for 1-1.5 hours, and collect the extract A; The pH of the extract A is adjusted to 4.2±0.1, and then cellulase and pectinase are added, and enzymolysis is performed at 55±0.1°C for 3.5-4h, and the enzymes are inactivated to obtain an enzymolysis solution; The enzymatic hydrolysate was filtered and the filtrate A was collected; the filtrate A was concentrated under reduced pressure to a relative density of 1.9-2.0 (50°C), and then ethanol was added and allowed to stand, and the supernatant was taken and concentrated under reduced pressure to a thick paste, which was then dried and crushed.

4. The lipid-lowering Ganoderma lucidum spore powder composition according to claim 3, characterized in that: The particle size of the salvia miltiorrhiza powder is 1-3 mm; the weight ratio of the salvia miltiorrhiza powder to water is 1:3; and the reflux extraction is performed twice.

5. The lipid-lowering Ganoderma lucidum spore powder composition according to claim 3, characterized in that: The added amount of cellulase is 2.5-3.3u / g, and the added amount of pectinase is 3.8-4.2u / g.

6. The lipid-lowering Ganoderma lucidum spore powder composition according to claim 3, characterized in that: After cooling, add ethanol until the alcohol content is 75%.

7. The lipid-lowering Ganoderma lucidum spore powder composition according to claim 1, characterized in that: Forsythia suspensa extract, the preparation method is as follows: Mix the Forsythia suspensa powder and water in a weight ratio of 1:3-5, decoct for 3 times, each time for 1.5 hours, and collect the extract B; The extract B was concentrated under reduced pressure to a relative density of 1.15-1.18 (room temperature); after cooling, 2-3 times of ethanol was added, allowed to stand, filtered, and the filtrate B was collected; the filtrate B was concentrated under reduced pressure to a thick paste, dried, and crushed.

8. The lipid-lowering Ganoderma lucidum spore powder composition according to claim 1, characterized in that: Licorice extract, preparation method is as follows: Slice licorice and mix with water in a weight ratio of 1:5-7, decoct for 3 times with stirring, each time for 2-3 hours, and collect extract C; The extract C was concentrated under reduced pressure to a thick paste, dried and crushed.

9. The lipid-lowering Ganoderma lucidum spore powder composition according to claim 8, characterized in that: The stirring speed is 30-50r / min.

10. The blood lipid-lowering Ganoderma lucidum spore powder according to claim 1 The method for preparing the composition is characterized in that: The process is as follows: (1) Ganoderma lucidum spore powder, salvia miltiorrhiza extract, forsythia suspensa extract and liquorice extract are prepared according to the ratio; (2) Place all components in a mixer and mix them evenly to obtain a composite material.