A traditional Chinese medicine compound composition for improving the immunity of pigeons and the quality of pigeon eggs

Abstract

The traditional Chinese medicine compound composition of the present invention takes Bupleurum chinense DC., Pueraria lobata (Willd.) Ohwi, Glycyrrhiza uralensis Fisch., Taraxacum mongolicum Hand.-Mazz., Astragalus membranaceus (Fisch.) Bunge, Scutellaria baicalensis Georgi, Notopterygium incisum Ting ex H. T. Chang, Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. ex Franch. et Sav., Paeonia lactiflora Pall., Platycodon grandiflorus (Jacq.) A. DC., Gypsum fibrosum, Kochia scoparia (L.) Schrad., Coix lacryma-jobi L., Sophora flavescens Ait., Coptis chinensis Franch., Poria cocos (Schw.) Wolf, Polygonatum sibiricum Redoute, Forsythia suspensa (Thunb.) Vahl, Galla chinensis, Curcuma zedoaria (Christm.) Rosc., Lonicera japonica Thunb., Isatis indigotica Fortune, Scrophularia ningpoensis Hemsl., Prunella vulgaris L., stir-fried Endothelium Corneum Gigeriae Galli, Rhizoma Dioscoreae, Pseudostellaria heterophylla (Miq.) Pax ex Pax et Hoffm., Artemisia capillaris Thunb., Humulus lupulus L. as the main components. After processing, it is prepared into a traditional Chinese medicine powder and mixed with the basic feed to feed pigeons. The said traditional Chinese medicine compound composition can not only be used as a health care drug to improve the immunity of pigeons, increase the weight of pigeons, and improve the quality of pigeon eggs, but also assist in treating pigeon diarrhea, and can be used as an efficient therapeutic drug with two-pronged effects, having high economic value and practicability.

Description

Technical Field

[0001] The present invention belongs to the field of pharmaceutical technology, and particularly relates to a traditional Chinese medicine compound composition for improving the immunity of pigeons and the quality of pigeon eggs, its preparation process, and the application of the traditional Chinese medicine compound composition in the treatment of non-infectious diarrhea. Background Art

[0002] After more than 40 years of development and accumulation, the pigeon breeding industry in China has entered a new round of rapid development period, which benefits from the rapid demand for high-quality poultry meat and eggs. The pigeon breeding industry has become a pillar industry in China's breeding industry. However, with large-scale breeding, the conditions of pigeon houses and the nutritional value of feed directly affect the body immunity of pigeons. For example, poor ventilation in pigeon houses, simple feed, frequent diarrhea, bacterial or trichomonad infections often occur, which easily cause slow growth of pigeons, decreased egg production, and decreased quality of pigeon eggs. Currently, the drugs used to prevent and treat pigeon diarrhea are mostly antibiotics, chemically synthesized drugs, etc. Although these drugs can play a certain therapeutic effect and achieve a certain prevention and treatment effect, they also bring a series of difficult problems such as an increase in drug-resistant strains and drug residues, seriously restricting the healthy development of the pigeon breeding industry. Summary of the Invention

[0003] The present invention provides a traditional Chinese medicine compound composition for improving the immunity of pigeons and the quality of pigeon eggs. The traditional Chinese medicine compound composition is composed of the following raw materials in parts by weight: 10 - 12 parts of Bupleurum chinense DC., 10 - 12 parts of Pueraria lobata (Willd.) Ohwi, 18 - 20 parts of Glycyrrhiza uralensis Fisch., 18 - 20 parts of Taraxacum mongolicum Hand.-Mazz., 18 - 20 parts of Astragalus membranaceus (Fisch.) Bunge, 10 - 12 parts of Scutellaria baicalensis Georgi, 10 - 12 parts of Notopterygium incisum Ting ex H. T. Chang, 10 - 12 parts of Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. ex Franch. et Sav., 10 - 12 parts of Paeonia lactiflora Pall., 10 - 12 parts of Platycodon grandiflorus (Jacq.) A. DC., 15 - 18 parts of Gypsum fibrosum, 10 - 12 parts of Kochia scoparia (L.) Schrad., 18 - 20 parts of Coix lacryma-jobi L., 15 - 18 parts of Sophora flavescens Ait., 10 - 12 parts of Coptis chinensis Franch., 15 - 18 parts of Poria cocos (Schw.) Wolf, 10 - 12 parts of Polygonatum sibiricum Redoute, 10 - 12 parts of Forsythia suspensa (Thunb.) Vahl, 10 - 12 parts of Galla chinensis, 15 - 18 parts of Curcuma zedoaria (Christm.) Rosc., 10 - 12 parts of Lonicera japonica Thunb., 18 - 20 parts of Isatis indigotica Fortune, 15 - 18 parts of Scrophularia ningpoensis Hemsl., 15 - 18 parts of Prunella vulgaris L., 15 - 18 parts of Endothelium corneum gigeriae galli, 15 - 18 parts of Dioscorea opposita Thunb., 15 - 18 parts of Pseudostellaria heterophylla (Miq.) Pax ex Pax et Hoffm., 10 - 12 parts of Artemisia capillaris Thunb., 10 - 12 parts of Humulus lupulus L.

[0004] Preferably, the traditional Chinese medicine compound composition is composed of the following raw materials in parts by weight: 12 parts of Bupleurum chinense, 10 parts of Pueraria lobata, 20 parts of Glycyrrhiza uralensis, 20 parts of Taraxacum mongolicum, 20 parts of Astragalus membranaceus, 12 parts of Scutellaria baicalensis, 10 parts of Notopterygium incisum, 10 parts of Angelica dahurica, 12 parts of Paeonia lactiflora, 10 parts of Platycodon grandiflorum, 15 parts of Gypsum fibrosum, 10 parts of Kochia scoparia, 20 parts of Coix lacryma-jobi, 15 parts of Sophora flavescens, 10 parts of Coptis chinensis, 15 parts of Poria cocos, 10 parts of Polygonatum sibiricum, 12 parts of Forsythia suspensa, 10 parts of Galla chinensis, 15 parts of Curcuma zedoaria, 12 parts of Lonicera japonica, 20 parts of Isatis indigotica, 15 parts of Scrophularia ningpoensis, 15 parts of Prunella vulgaris, 15 parts of stir-fried Endothelium corneum gigeriae galli, 15 parts of Dioscorea opposita, 15 parts of Pseudostellaria heterophylla, 12 parts of Artemisia capillaris, and 10 parts of Humulus lupulus.

[0005] The active ingredients of the drug efficacy provided by the present invention are as follows:

[0006] Bupleurum chinense: It has the effects of reconciling the exterior and interior, soothing the liver and ascending yang.

[0007] Pueraria lobata: It has the effect of relieving muscle fever.

[0008] Glycyrrhiza uralensis: It has the effects of replenishing qi and tonifying the middle, clearing heat and detoxifying, and resolving phlegm and relieving cough. When combined with other herbs, it also has the effect of moistening dryness and lubricating the intestines. The active ingredient for treating diarrhea is glycyrrhizin.

[0009] Taraxacum mongolicum: Taraxacum mongolicum contains components such as taraxacin and taraxasterol, and has effects such as antibacterial, anti-inflammatory, and diuretic.

[0010] Astragalus membranaceus: Astragalus membranaceus contains components such as astragalus polysaccharide and astragaloside, and has effects such as enhancing immunity and antibacterial.

[0011] Scutellaria baicalensis: It has the effects of clearing heat and drying dampness, purging fire and detoxifying.

[0012] Notopterygium incisum: It has the effects of dispelling wind-cold and expelling wind-dampness.

[0013] Angelica dahurica: It has the effects of dispelling wind-cold and reducing swelling and discharging pus.

[0014] Paeonia lactiflora: It has the effects of nourishing blood and regulating menstruation, astringing yin and stopping sweating, soothing the liver and relieving pain, and suppressing hyperactive liver-yang.

[0015] Platycodon grandiflorum: Platycodon grandiflorum contains components such as platycodin and platycogenic acid, and has effects such as anti-inflammatory, expectorant, and enhancing immunity.

[0016] Gypsum fibrosum: Gypsum fibrosum contains components such as calcium sulfate, and has effects such as clearing heat and detoxifying, and relieving diarrhea.

[0017] Kochia scoparia: Kochia scoparia contains components such as volatile oil and flavonoids, and has effects such as anti-inflammatory, antibacterial, and diuretic.

[0018] Coix lacryma-jobi: Coix lacryma-jobi contains components such as coixenolide and coixan, and has effects such as enhancing immunity, anti-inflammatory, and anti-cancer.

[0019] Sophora flavescens: Sophora flavescens contains components such as matrine and oxymatrine, and has effects of anti - inflammation, anti - bacteria, anti - virus, etc.

[0020] Coptis chinensis: Coptis chinensis contains components such as berberine and berberine hydrochloride, and has effects of anti - bacteria, anti - inflammation, and enhancing immunity, etc.

[0021] Poria cocos: Poria cocos contains components such as pachyman and poric acid, and has effects of enhancing immunity and anti - inflammation, etc.

[0022] Polygonatum sibiricum: Polygonatum sibiricum contains components such as polygonatum polysaccharide and steroidal saponins, and has effects of enhancing immunity and anti - oxidation, etc.

[0023] Forsythia suspensa: Forsythia suspensa contains components such as phillyrin and forsythoside, and has effects of anti - bacteria, anti - inflammation, anti - virus, etc.

[0024] Chinese gall: Chinese gall contains components such as gallotannin, and has effects of anti - bacteria and antidiarrheal, etc.

[0025] Curcuma zedoaria: Curcuma zedoaria contains components such as volatile oil and curcumol, and has effects of anti - inflammation, anti - bacteria, and anti - cancer, etc.

[0026] Honeysuckle flower: Honeysuckle flower contains components such as chlorogenic acid and luteolin, and has effects of anti - bacteria, anti - inflammation, anti - virus, etc.

[0027] Folium isatidis: Folium isatidis contains components such as indirubin and indigo, and has effects of anti - bacteria, anti - virus, and anti - inflammation, etc.

[0028] Scrophularia ningpoensis: Scrophularia ningpoensis contains components such as saponins and alkaloids, and has effects of anti - bacteria, anti - inflammation, and enhancing immunity, etc.

[0029] Prunella vulgaris L.: Prunella vulgaris L. contains components such as flavonoids and volatile oil, and has effects of anti - bacteria and anti - inflammation, etc.

[0030] Stir - fried Endothelium Corneum Gigeriae Galli: Stir - fried Endothelium Corneum Gigeriae Galli contains components such as gastric hormone and keratin, and has effects of promoting digestion and enhancing appetite, etc.

[0031] Rhizoma Dioscoreae: Rhizoma Dioscoreae contains components such as dioscorea alkaloid and mucoprotein, and has effects of enhancing immunity and anti - fatigue, etc.

[0032] Pseudostellaria heterophylla: Pseudostellaria heterophylla contains components such as pseudostellaria heterophylla polysaccharide and steroidal saponins, and has the effect of enhancing immunity.

[0033] Artemisia capillaris: Artemisia capillaris contains components such as capillarisin and volatile oil, and has effects of anti - bacteria and anti - inflammation, etc.

[0034] Humulus lupulus: Humulus lupulus contains components such as volatile oil and alkaloids, and has effects of anti - inflammation and enhancing immunity, etc.

[0035] In the field of traditional Chinese medicine, the compatibility of drugs is an important means to improve efficacy and reduce toxic and side effects. Through extensive research, the inventors of this application found that the traditional Chinese medicine compound composition is optimally mixed with the following weight ratios of ingredients: 12 parts of Bupleurum chinense DC., 10 parts of Pueraria lobata (Willd.) Ohwi, 20 parts of Glycyrrhiza uralensis Fisch., 20 parts of Taraxacum mongolicum Hand.-Mazz., 20 parts of Astragalus membranaceus (Fisch.) Bunge, 12 parts of Scutellaria baicalensis Georgi, 10 parts of Notopterygium incisum Ting ex H. T. Chang, 10 parts of Angelica dahurica (Fisch.) Benth. et Hook. f. ex Franch. et Sav., 12 parts of Paeonia lactiflora Pall., 10 parts of Platycodon grandiflorus (Jacq.) A. DC., 15 parts of Gypsum fibrosum, 10 parts of Kochia scoparia (L.) Schrad., 20 parts of Coix lacryma-jobi L., 15 parts of Sophora flavescens Ait., 10 parts of Coptis chinensis Franch., 15 parts of Poria cocos (Schw.) Wolf, 10 parts of Polygonatum sibiricum Redoute, 12 parts of Forsythia suspensa (Thunb.) Vahl, 10 parts of Gallnut, 15 parts of Curcuma zedoaria (Christm.) Rosc., 12 parts of Lonicera japonica Thunb., 20 parts of Isatis indigotica Fort., 15 parts of Scrophularia ningpoensis Hemsl., 15 parts of Prunella vulgaris L., 15 parts of Stir-fried Endothelium Corneum Gigeriae Galli, 15 parts of Dioscorea opposita Thunb., 15 parts of Pseudostellaria heterophylla (Miq.) Pax ex Pax et Hoffm., 12 parts of Artemisia capillaris Thunb., 10 parts of Humulus lupulus L. When the total dosage of the compound is the same, minor changes in the dosage of each drug have little impact on the experimental results. Therefore, the traditional Chinese medicine compound composition of the present invention is composed of the following ingredients in parts by weight: 10-12 parts of Bupleurum chinense DC., 10-12 parts of Pueraria lobata (Willd.) Ohwi, 18-20 parts of Glycyrrhiza uralensis Fisch., 18-20 parts of Taraxacum mongolicum Hand.-Mazz., 18-20 parts of Astragalus membranaceus (Fisch.) Bunge, 10-12 parts of Scutellaria baicalensis Georgi, 10-12 parts of Notopterygium incisum Ting ex H. T. Chang, 10-12 parts of Angelica dahurica (Fisch.) Benth. et Hook. f. ex Franch. et Sav., 10-12 parts of Paeonia lactiflora Pall., 10-12 parts of Platycodon grandiflorus (Jacq.) A. DC., 15-18 parts of Gypsum fibrosum, 10-12 parts of Kochia scoparia (L.) Schrad., 18-20 parts of Coix lacryma-jobi L., 15-18 parts of Sophora flavescens Ait., 10-12 parts of Coptis chinensis Franch., 15-18 parts of Poria cocos (Schw.) Wolf, 10-12 parts of Polygonatum sibiricum Redoute, 10-12 parts of Forsythia suspensa (Thunb.) Vahl, 10-12 parts of Gallnut, 15-18 parts of Curcuma zedoaria (Christm.) Rosc., 10-12 parts of Lonicera japonica Thunb., 18-20 parts of Isatis indigotica Fort., 15-18 parts of Scrophularia ningpoensis Hemsl., 15-18 parts of Prunella vulgaris L., 15-18 parts of Stir-fried Endothelium Corneum Gigeriae Galli, 15-18 parts of Dioscorea opposita Thunb., 15-18 parts of Pseudostellaria heterophylla (Miq.) Pax ex Pax et Hoffm., 10-12 parts of Artemisia capillaris Thunb., 10-12 parts of Humulus lupulus L.

[0036] More importantly, through multiple experimental studies, it was found that in this traditional Chinese medicine prescription, the mutual compatibility between Glycyrrhiza uralensis Fisch., Taraxacum mongolicum Hand.-Mazz., Astragalus membranaceus (Fisch.) Bunge, Poria cocos (Schw.) Wolf, Gypsum fibrosum, Coptis chinensis Franch., and Platycodon grandiflorus (Jacq.) A. DC. is crucial. When the weight ratio of Glycyrrhiza uralensis Fisch., Taraxacum mongolicum Hand.-Mazz., Astragalus membranaceus (Fisch.) Bunge, Poria cocos (Schw.) Wolf, Gypsum fibrosum, Coptis chinensis Franch., and Platycodon grandiflorus (Jacq.) A. DC. is 4:4:4:3:3:2:2, the cost performance of the drug can be maximized. If the dosages of Coptis chinensis Franch. and Platycodon grandiflorus (Jacq.) A. DC. are too high, it is easy to cause indigestion, affecting the feed intake and weight loss of pigeons. As one of the monarch drug components, Glycyrrhiza uralensis Fisch., Taraxacum mongolicum Hand.-Mazz., and Astragalus membranaceus (Fisch.) Bunge can effectively improve non-infectious diarrhea in caged pigeons and greatly shorten the recovery time when used in high ratios.

[0037] In addition, through dose screening, it was found that preferably, when the weight ratio of the traditional Chinese medicine compound composition to the basal diet is 0.5 g / kg - 1 g / kg, the cost performance of the drug can be maximized. More preferably, the weight ratio of the traditional Chinese medicine compound composition to the basal diet is 0.5 g / kg.

[0038] On the other hand, the present invention also provides a preparation process for the traditional Chinese medicine compound composition, including the following steps:

[0039] S1: Weigh gypsum and Chinese gall, crush them into powder to obtain a crushed product.

[0040] S2: Weigh the remaining medicinal materials, add 3 - 5 times the amount of water, soak for 1 - 3 hours, then cook for 3 - 5 hours, filter, and concentrate to obtain an extract.

[0041] S3: Mix the crushed product obtained in step S1 and the extract obtained in step S2, and perform low - temperature drying at 30 - 40 °C to obtain a powder.

[0042] In some embodiments, in step S1, the particle size of the powder obtained by crushing is 40 mesh.

[0043] In some embodiments, in step S2, add 3 times the amount of water and soak for 1.5 hours.

[0044] In some embodiments, in step S2, the cooking time is 3 hours.

[0045] On the other hand, the application of the traditional Chinese medicine compound composition of the present invention in the preparation of a drug for improving the immunity of pigeons and improving the quality of pigeon eggs.

[0046] On the other hand, the application of the traditional Chinese medicine compound composition of the present invention in the preparation of a drug for treating non - infectious diarrhea in pigeons.

[0047] Beneficial effects:

[0048] Combined with the above - mentioned technical solutions and the technical problems to be solved, the beneficial effects of the technical solutions to be protected by the present invention are analyzed from the following aspects:

[0049] 1. Improve the immunity of pigeons: The traditional Chinese medicine compound composition provided by the present invention takes Bupleurum chinense, Pueraria lobata, Glycyrrhiza uralensis, Taraxacum mongolicum, Astragalus membranaceus, Scutellaria baicalensis, Notopterygium incisum, Angelica dahurica, Paeonia lactiflora, Platycodon grandiflorum, Gypsum, Kochia scoparia, Coix lacryma - jobi, Sophora flavescens, Coptis chinensis, Poria cocos, Polygonatum sibiricum, Forsythia suspensa, Chinese gall, Curcuma zedoaria, Lonicera japonica, Isatis indigotica, Scrophularia ningpoensis, Prunella vulgaris, stir - fried Endothelium corneum gigeriae galli, Dioscorea opposita, Pseudostellaria heterophylla, Artemisia capillaris, Humulus lupulus as the main components, and is processed into a traditional Chinese medicine powder. Through clinical and pharmacodynamic tests, it is found that this traditional Chinese medicine compound composition can significantly improve the immunity of pigeons and reduce the mortality rate of pigeons. By adding 0.5 g / kg - 1 g / kg of the traditional Chinese medicine compound composition to the basic feed, the weight of pigeons increases significantly and the mortality rate decreases significantly.

[0050] 2. Improve the quality of pigeon eggs: The traditional Chinese medicine compound composition of the present invention can significantly improve the quality of pigeon eggs, increase the eggshell strength, and reduce the breakage rate of pigeon eggs during transportation and storage. Experimental data show that after using the traditional Chinese medicine compound composition of the present invention, the eggshell strength of pigeon eggs is significantly higher than that of the blank control group, and the egg weight also increases, which is more conducive to improving the market competitiveness of pigeon eggs.

[0051] 3. Treatment of non-infectious diarrhea: In the treatment of diarrhea diseases in pigeons, due to the complex etiology of non-infectious diarrhea in caged pigeons, it is impossible to accurately identify the cause. Different from bacterial or viral infections, treatment drugs such as antibiotics have no therapeutic effect on this disease, or even if antibiotics are used for treatment, a series of difficult problems such as the increase of drug-resistant strains and drug residues are easily brought about. The traditional Chinese medicine compound composition described in the present invention can treat non-infectious diarrhea in caged pigeons, with quick onset and good curative effect, filling the technical gap that there is no accurate treatment method and effective drug for this disease.

[0052] In summary, the traditional Chinese medicine compound composition provided by the present invention can not only be used as a health care drug to improve the immunity of pigeons, promote the weight gain of pigeons, and improve the quality of pigeon eggs, but also assist in the treatment of non-infectious diarrhea in pigeons. It can be used as an efficient treatment drug with two-pronged approach, having high economic value and practicability. Detailed implementation mode

[0053] The following combines examples to further describe in detail the specific implementation mode of the present invention. The following examples are used to illustrate the present invention, but not to limit the scope of the present invention.

[0054] The reagents or consumables used in the present invention are all commercially available unless otherwise specified.

[0055] Example 1

[0056] Traditional Chinese medicine compound composition: 12 parts of Bupleurum chinense, 10 parts of Pueraria lobata, 20 parts of Glycyrrhiza uralensis, 20 parts of Taraxacum mongolicum, 20 parts of Astragalus membranaceus, 12 parts of Scutellaria baicalensis, 10 parts of Notopterygium incisum, 10 parts of Angelica dahurica, 12 parts of Paeonia lactiflora, 10 parts of Platycodon grandiflorum, 15 parts of Gypsum fibrosum, 10 parts of Kochia scoparia, 20 parts of Coix lacryma-jobi, 15 parts of Sophora flavescens, 10 parts of Coptis chinensis, 15 parts of Poria cocos, 10 parts of Polygonatum sibiricum, 12 parts of Forsythia suspensa, 10 parts of Gallnut, 15 parts of Curcuma zedoaria, 12 parts of Lonicera japonica, 20 parts of Isatis indigotica, 15 parts of Scrophularia ningpoensis, 15 parts of Prunella vulgaris, 15 parts of stir-fried Endothelium corneum gigeriae galli, 15 parts of Dioscorea opposita, 15 parts of Pseudostellaria heterophylla, 12 parts of Artemisia capillaris, 10 parts of Humulus lupulus;

[0057] Preparation process:

[0058] S1) Crushing treatment: Weigh the above-mentioned parts by weight of Gypsum fibrosum and Gallnut, crush them into powders, and pass through a 40-mesh sieve to obtain crushed materials;

[0059] S2) Extraction treatment: Weigh the remaining medicinal materials, add 3 times the amount of water, soak for 1.5 hours, then cook for 3 - 5 hours, filter, and concentrate to obtain an extract;

[0060] S3) Mix the crushed materials obtained in step S1) and the extract obtained in step S2), and perform low-temperature drying at 30°C to obtain a powder.

[0061] Comparative example 1

[0062] Traditional Chinese medicine compound composition: 12 parts of Bupleurum chinense, 20 parts of Astragalus membranaceus, 15 parts of Poria cocos, 20 parts of Glycyrrhiza uralensis.

[0063] Preparation process:

[0064] Weigh the medicinal materials in the above weight parts, add 3 times the amount of water and soak for 1.5 hours, then cook for 3 - 5 hours, filter, concentrate to obtain an extract; perform low-temperature drying at 30°C to obtain a powder.

[0065] Comparative example 2

[0066] Traditional Chinese medicine compound composition: 12 parts of Bupleurum chinense, 20 parts of Astragalus membranaceus, 15 parts of Poria cocos, 20 parts of Glycyrrhiza uralensis, 12 parts of Scutellaria baicalensis, 15 parts of Prunella vulgaris, 12 parts of Forsythia suspensa, 10 parts of Galla chinensis, 15 parts of Pseudostellaria heterophylla, 12 parts of Artemisia capillaris.

[0067] Preparation process:

[0068] Weigh the medicinal materials in the above weight parts, add 3 times the amount of water and soak for 1.5 hours, then cook for 3 - 5 hours, filter, concentrate to obtain an extract; perform low-temperature drying at 30°C to obtain a powder.

[0069] Comparative example 3

[0070] Traditional Chinese medicine compound composition: 12 parts of Bupleurum chinense, 10 parts of Pueraria lobata, 20 parts of Glycyrrhiza uralensis, 20 parts of Taraxacum mongolicum, 20 parts of Astragalus membranaceus, 12 parts of Scutellaria baicalensis, 10 parts of Notopterygium incisum, 10 parts of Angelica dahurica, 12 parts of Paeonia lactiflora, 10 parts of Platycodon grandiflorum, 15 parts of Gypsum fibrosum, 10 parts of Kochia scoparia, 20 parts of Coix lacryma-jobi, 15 parts of Sophora flavescens, 10 parts of Coptis chinensis, 15 parts of Poria cocos, 10 parts of Polygonatum sibiricum, 12 parts of Forsythia suspensa, 10 parts of Galla chinensis, 15 parts of Curcuma zedoaria, 12 parts of Lonicera japonica, 20 parts of Isatis indigotica, 15 parts of Scrophularia ningpoensis, 15 parts of Prunella vulgaris, 15 parts of stir-fried Endothelium corneum gigeriae galli, 15 parts of Dioscorea opposita, 15 parts of Pseudostellaria heterophylla, 12 parts of Artemisia capillaris, 10 parts of Humulus lupulus;

[0071] Preparation process:

[0072] Weigh the above Chinese medicine ingredients, crush, mix evenly, and pass through a 40-mesh sieve to obtain a powder.

[0073] Experimental example 1

[0074] Test animals and test methods

[0075] 1.1 Test subjects: Select 500 healthy adult pigeons with comparable weights from this pigeon farm.

[0076] 1.2 Test method: It was evenly divided into 5 test groups, namely the blank control group, the example group, control group 1, control group 2, and control group 3, with 100 in each group. Each group had a pre-feeding period of 7 days. During the pre-feeding period, the basic feed was uniformly fed. At the beginning of the formal period, the basic feed was fed daily (blank control group). The addition amount of the traditional Chinese medicine compound composition powder obtained in Example 1 in the feed was 0.5 g / kg (traditional Chinese medicine compound composition / feed) as the example group, and the addition amounts of the traditional Chinese medicine compound composition powder obtained in Comparative Example 1, Comparative Example 2, and Comparative Example 3 in the feed were 0.5 g / kg (traditional Chinese medicine compound composition / feed) as control group 1, control group 2, and control group 3 respectively for 7 consecutive days, and then the basic feed was fed for 14 days, for a total of 21 days. This was repeated three cycles, for a total of 63 days.

[0077] 1.3 Performance measurement method

[0078] 1.3.1 Quality indicators of pigeon eggs

[0079] Record the egg weight and shell strength of each group, and process the recorded data. The measurement methods are as follows, and the measurement results are shown in Table 1.

[0080] Egg weight: Weigh with an electronic balance, and the weighing value is accurate to 0.1 g, and calculate the average value.

[0081] Shell strength: Shell strength is the pressure (N / cm 2 ) received by the eggshell per unit area. The stronger the shell strength, the more resistant it is to collisions during the circulation process and the lower the breakage rate. It can be measured with an eggshell strength tester.

[0082] Table 1 Detection results of pigeon egg performance

[0083] Group Egg weight (g) <![CDATA[Eggshell strength (N / cm 2 )]]> Blank control group 18.1±0.1 3.35±0.15 Example group 18.5±0.1 3.65±0.16 Control group 1 18.2±0.2 3.45±0.12 Control group 2 18.2±0.1 3.55±0.14 Control group 3 18.4±0.3 3.61±0.19

[0084] 1.3.2 Growth and development of pigeons

[0085] Observe the weight gain and mortality of pigeons throughout the cycle. The measurement results are shown in Table 2.

[0086] Table 2 Weight changes and mortality of pigeons

[0087]

[0088] As can be seen from Table 1, compared with the blank control group, when the traditional Chinese medicine composition provided by the present invention is used as a feed additive, the weight of pigeon eggs in the example group increases, and especially the eggshell strength is significantly higher than that of the blank control group (P < 0.05). Compared with Control Groups 1 - 3, the weight of pigeon eggs and the eggshell strength are significantly improved. As can be seen from Table 2, the traditional Chinese medicine compound composition described in the examples of the present invention is beneficial to the growth of pigeons. Especially for the example group, it does not affect the feed intake of pigeons, the body weight of pigeons increases significantly, and the mortality rate is relatively low.

[0089] Experimental Example 2 Selection of the Optimal Dosage of the Traditional Chinese Medicine Compound Composition Granules

[0090] Pigeons were fed with the traditional Chinese medicine compound composition at 0.2 g, 0.5 g, 1.0 g, and 2.0 g / kg of traditional Chinese medicine compound composition / feed. Among them, the dosages of 0.5 g / kg and 1.0 g / kg can make the egg weight of pigeon eggs moderate, and can maintain good eggshell strength, reducing the breakage rate of pigeon eggs. Among them, when the Chinese medicine content is increased to 2.0 g / kg of traditional Chinese medicine compound composition / feed, the proportion of Chinese medicine increases, which affects the feed intake, and the body weight of pigeons increases slowly. Using a lower Chinese medicine content, such as 0.2 g / kg of traditional Chinese medicine compound composition / feed, has less improvement on the quality of pigeon eggs. Therefore, considering the influence on the quality of pigeon eggs, the growth and development of pigeons, as well as the economic cost, the present invention selects 0.5 - 1 g / kg as the optimal dosage. The results are shown in Table 3.

[0091] Table 3 Results of Screening the Optimal Dosage of the Traditional Chinese Medicine Compound Composition Granules

[0092]

[0093] In summary, as can be seen from Tables 1 - 3, the traditional Chinese medicine compound composition of the present invention is beneficial to improving the immunity of pigeons. Regularly feeding the traditional Chinese medicine compound composition described in the present invention during normal feeding can effectively increase the body weight of pigeons and reduce the mortality rate of pigeons.

[0094] In terms of the quality of pigeon eggs, the traditional Chinese medicine compound composition of the present invention significantly improves the eggshell strength, thereby improving the quality of pigeon eggs and reducing the breakage of pigeon eggs during production and transportation.

[0095] Experimental Example 3

[0096] 3.1. Influence on Pigeons Suffering from Non - Infectious Diarrhea without Treatment Measures

[0097] Pigeons with diarrhea in a pigeon farm in Ruian City, Zhejiang Province were observed. The condition changes of the pigeons were observed on the 1st, 3rd, 5th, 7th, and 9th days respectively. It was found that if the diarrhea was not treated in time, the feed intake of the pigeons was less, the body weight decreased, and there was also death. The results are shown in Table 4.

[0098] Table 4 Condition Changes of Pigeons 9 Days after Suffering from Non - Infectious Diarrhea

[0099]

[0100] 3.2 Therapeutic Effect of Traditional Chinese Medicine Compound Composition Preparation on Non-Infectious Diarrhea in Pigeons

[0101] Medication Method: 40 pigeons suffering from non-infectious diarrhea in the pigeon farm were selected and fed with 0.5 g / kg (traditional Chinese medicine compound composition / feed) for 3 days. The condition changes of the pigeons were observed on the 1st, 3rd, 5th, 7th, and 9th days respectively. The results are shown in Table 5.

[0102] Table 5 Therapeutic Effect of Traditional Chinese Medicine Compound Composition

[0103]

[0104] As can be seen from the above table, when using the traditional Chinese medicine compound composition described in this embodiment to treat pigeons suffering from non-infectious diarrhea, the number of dead pigeon cases significantly decreased, and the mortality rate was only 7.5%. On the 5th day, the pigeons began to resume food intake, and their body weights returned to normal.

[0105] 3.3 Comparison of Therapeutic Effects between Traditional Chinese Medicine Compound Composition Preparation and Other Treatment Methods

[0106] Non-infectious diarrhea in pigeons is often caused by improper pigeon house environment, diet structure, and gastrointestinal flora imbalance. Different from bacterial or viral infections, treatment drugs such as antibiotics have no therapeutic effect on this disease, or even if antibiotics are used for treatment, a series of difficult problems such as an increase in drug-resistant strains and drug residues are likely to occur. However, measures to improve the pigeon house environment or adjust the diet structure are slow to take effect and have a high pigeon mortality rate. 90 pigeons suffering from non-infectious diarrhea in the pigeon house were treated. They were randomly divided into 3 groups, with 30 pigeons in each group. They were respectively treated with improving the pigeon house, adjusting the diet, and traditional Chinese medicine compound composition (0.5 g / kg (traditional Chinese medicine compound composition of Example 1 / feed)) for 7 days. After observing for 30 days, the mortality rate, recovery time, and changes in pigeon body weight of different treatment methods were statistically analyzed. The comparison of therapeutic effects is shown in Table 6.

[0107] Table 6 Comparison of Therapeutic Effects between Traditional Chinese Medicine Compound Composition Granules and Other Treatment Methods

[0108]

[0109] As can be seen from Tables 4 - 6 above, for pigeons suffering from non-infectious diarrhea, using the traditional Chinese medicine compound composition described in this embodiment effectively improved the diarrhea symptoms of the pigeons, greatly shortened the recovery time, simultaneously improved the food intake of the pigeons, maintained the body weight unchanged, and reduced the mortality rate of the pigeons.

[0110] In summary, the performance of the traditional Chinese medicine compound composition described in the present invention in aspects such as pigeon egg quality is superior to that of the blank control group. Moreover, the traditional Chinese medicine compound composition does not add antibiotics, will not cause drug resistance, and will not pose a hidden danger to food safety, providing a new idea for a non-antibiotic, green and healthy breeding mode. In addition, the traditional Chinese medicine compound composition can also promote the absorption of nutrients by the body, quickly restore the damaged functions of the body, improve the immunity of pigeons, significantly improve the diarrhea symptoms of pigeons suffering from non-infectious diarrhea, greatly shorten the recovery time, while improving the feed intake of pigeons, keeping the weight unchanged, and reducing the mortality rate of pigeons.

[0111] The above are only the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the technical principle of the present invention, several improvements and substitutions can be made, and these improvements and substitutions should also be regarded as the protection scope of the present invention.

Claims

1. A Chinese medicinal compound composition for improving pigeon immunity and pigeon egg quality, characterized in that: The Chinese medicine compound composition is composed of the following raw materials in parts by weight: 10-12 parts of northern bupleurum, 10-12 parts of pueraria root, 18-20 parts of liquorice, 18-20 parts of dandelion, 18-20 parts of astragalus, 10-12 parts of scutellaria, 10-12 parts of notopterygium, 10-12 parts of angelica dahurica, 10-12 parts of white peony root, 10-12 parts of platycodon, 15-18 parts of gypsum, 10-12 parts of kochia fruit, 18-20 parts of coix seed, 15-18 parts of sophora flavescens, 10-12 parts of coptis root, and 15-18 parts of tuckahoe , 10-12 parts of polygonatum, 10-12 parts of forsythia, 10-12 parts of gallnut, 15-18 parts of curcuma, 10-12 parts of honeysuckle, 18-20 parts of isatis indigotica, 15-18 parts of yuanshen, 15-18 parts of selfhealing flower, 15-18 parts of stir-fried chicken gizzard lining, 15-18 parts of yam, 15-18 parts of pseudostellaria, 10-12 parts of capillaris, and 10-12 parts of hops; among which, the weight ratio of licorice, dandelion, astragalus, poria, gypsum, coptis and platycodon is 4:4:4:3:3:2:

2.

2. The Chinese medicine compound composition according to claim 1, characterized in that: The Chinese medicine compound composition is composed of the following raw materials in parts by weight: 12 parts of northern bupleurum, 10 parts of pueraria root, 20 parts of liquorice, 20 parts of dandelion, 20 parts of astragalus, 12 parts of scutellaria, 10 parts of notopterygium, 10 parts of angelica dahurica, 12 parts of white peony root, 10 parts of platycodon, 15 parts of gypsum, 10 parts of kochia fruit, 20 parts of coix seed, 15 parts of sophora flavescens, 10 parts of coptis root, 15 parts of poria, 10 parts of polygonatum, 12 parts of forsythia, 10 parts of gallnut, 15 parts of curcuma, 12 parts of honeysuckle, 20 parts of isatis indigotica, 15 parts of yuanshen, 15 parts of prunella vulgaris, 15 parts of stir-fried chicken gizzard lining, 15 parts of yam, 15 parts of pseudostellaria, 12 parts of capillaris, and 10 parts of hemp seeds.

3. The Chinese medicine compound composition according to claim 1, characterized in that: The preparation process of the Chinese medicine compound composition comprises the following steps: S1: Weigh gypsum and gallnut, crush them into powder, and obtain a crushed material; S2: Weigh the remaining medicinal materials, add 3-5 times the amount of water, soak for 1-3 hours, boil for 3-5 hours, filter, concentrate, and obtain an extract; S3: The crushed product obtained in step S1 and the extract obtained in step S2 are mixed, and low-temperature dried at 30-40° C. to obtain a powder.

4. The Chinese medicine compound composition according to claim 3, characterized in that: In the step S1, the particle size of the powder is 40 mesh.

5. The Chinese medicine compound composition according to claim 3, characterized in that: In step S2, 3 times the amount of water is added and soaked for 1.5 hours.

6. The Chinese medicine compound composition according to claim 3, characterized in that: In step S2, the cooking time is 3 hours.

7. Application of the Chinese medicinal compound composition as described in any one of claims 1-6 in preparing a medicine for improving pigeon immunity and improving pigeon egg quality.

8. Use of the Chinese medicinal compound composition according to any one of claims 1 to 6 in the preparation of a medicament for treating non-infectious diarrhea in pigeons.

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