Composition containing citrus polyphenol and citrus powder for burning fat and losing weight as well as preparation method and application of composition

Abstract

The invention belongs to the technical field of extraction of effective components of medicines, and particularly relates to a composition containing citrus polyphenol and citrus powder for burning fat and losing weight as well as a preparation method and application of the composition. The composition comprises spray-dried powder and compound probiotics, wherein the spray-dried powder is prepared from citrus fruit filtrate, flammulina velutipes fibers, soybean protein isolate, an aronia extract and a black tea extract, and the compound probiotics comprise lactobacillus acidophilus, lactobacillus plantarum, lactobacillus rhamnosus, bifidobacterium lactis and lactobacillus casei. The flammulina velutipes fiber, the soybean protein isolate, the aronia extract, the black tea extract and the citrus fruit filtrate are subjected to compound spraying, the stability of total polyphenol and Vc in citrus fruits is improved, the obtained citrus powder is further mixed with compound probiotics to prepare the composition with pharmacodynamic active ingredients, fat can be effectively combusted, weight can be effectively reduced, and the health-care effect is good. The compound can be applied to weight-losing medicines or health products.

Description

Technical Field

[0001] The invention belongs to the technical field of extracting effective ingredients of medicines, and its international classification number is A61K36. It particularly relates to a composition containing citrus polyphenols and citrus powder for burning fat and losing weight, and a preparation method and application thereof. Background Art

[0002] In recent years, with the continuous improvement of living standards, people pay more and more attention to their own health, and taking some medicines or health care preparations appropriately to maintain health has gradually become a trend in daily consumption.

[0003] Due to the obesity faced by modern people due to changes in their lifestyle and eating habits and the overall health problems caused by obesity, as well as the increased demand for healthy food by modern people, it is of great significance to study a composition for burning fat and losing weight that can effectively reduce body fat content and slow down the chance of regaining weight, as well as its preparation method and application. Summary of the invention

[0004] In view of this, the present invention provides a composition containing citrus polyphenols and citrus powder for burning fat and losing weight, and a preparation method and application thereof.

[0005] In order to achieve the above object, the present invention adopts the following technical solution: A composition containing citrus polyphenols and citrus powder for burning fat and losing weight comprises citrus powder and probiotics.

[0006] The citrus powder comprises citrus fruit filtrate, enoki mushroom fiber, soy protein isolate, aronia berry extract and black tea extract.

[0007] Preferably, the citrus powder comprises, by weight, 80-90 parts of citrus fruit filtrate, 1-2 parts of Flammulina velutipes fiber, 1-5 parts of soy protein isolate, 5-8 parts of aronia berry extract, and 2-5 parts of black tea extract.

[0008] The citrus fruit filtrate is prepared by taking citrus fruits with skin as raw materials.

[0009] The dietary fiber content of the citrus powder is ≥40%, the total polyphenol content is ≥5%, and the VC content is ≥2%.

[0010] The caffeine content of the black tea extract is ≥0.5%.

[0011] The probiotics are composite probiotics, and the composite probiotics include Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium lactis, and Lactobacillus casei.

[0012] Further preferably, the content of the composite probiotics is 1-5*10^ 8 cfu / g.

[0013] Preferably, the citrus powder composition comprises 90 parts of citrus powder and 1-10 parts of probiotics by weight.

[0014] The preparation method of the composition containing citrus polyphenols and citrus powder for burning fat and losing weight comprises the following steps: S1. Crush and homogenize the citrus fruits with skin, and filter to obtain citrus fruit filtrate; S2, adding 5-10 times volume of water to fresh Flammulina velutipes, extracting at 80-90° C., filtering, washing, separating, drying to obtain Flammulina velutipes crude fiber, crushing, and sieving through 20-40 mesh to obtain Flammulina velutipes fiber; S3, crushing the dried aronia berry, sieving through a 100-200 mesh, adding 30-50 times volume of water, extracting at 70-90° C. for 0.5-1 h, filtering and concentrating the filtrate to 1 / 3-1 / 5 volume, to obtain an aronia berry extract; S4, crushing the dried black tea, sieving through a 100-200 mesh, adding 30-50 times volume of water, extracting at 80-100° C. for 0.5-1 h, filtering and concentrating the filtrate to obtain a black tea extract; S5. Mix the citrus fruit filtrate, Flammulina velutipes fiber, soy protein isolate, aronia berry extract, and black tea extract, and spray-dry to obtain citrus powder.

[0015] S6. Mix the probiotics and citrus powder to obtain a citrus powder composition.

[0016] The composition containing citrus polyphenols and citrus powder for burning fat and losing weight can be used to prepare products for burning fat and losing weight.

[0017] Furthermore, the fat burning and weight loss products include pharmaceutical products or health products.

[0018] Beneficial effects: 1. The present invention uses Flammulina velutipes fiber, soy protein isolate, aronia extract, black tea extract and citrus fruit filtrate for spray drying, which can effectively extract the active ingredients and is beneficial to maintaining the activity of Vc, thereby increasing the content of Vc in citrus powder and increasing the effect of resisting human aging.

[0019] 2. The present invention uses citrus powder and compound probiotics to achieve a synergistic fat burning and weight loss effect, has a simple preparation process, and can be used to prepare medicines or health care preparations. DETAILED DESCRIPTION

[0020] The technical scheme of the present invention is further described below in conjunction with specific examples. The composite probiotics used in the following examples are purchased from Shandong Pingao Pharmaceutical Co., Ltd. The composite probiotics include Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium lactis, and Lactobacillus casei. Other raw materials, unless otherwise specified, can be obtained from conventional commercial channels; the processes used, unless otherwise specified, all adopt conventional processes in the art.

[0021] Example 1 A composition containing citrus polyphenols and citrus powder for burning fat and losing weight, comprising, by weight, 90 parts of citrus powder and 5 parts of composite probiotics (1*10^8 cfu / g).

[0022] The preparation method of the citrus powder composition is as follows: S1. Crush and homogenize the citrus fruits with skin, and filter to obtain citrus fruit filtrate; S2, adding 10 times volume of water to fresh Flammulina velutipes, stirring and extracting at 200 rpm at 80°C for 1 hour, filtering through 400 mesh, washing with 10 times volume of water, filtering through 400 mesh to obtain solids, drying at 45°C to obtain Flammulina velutipes crude fiber, crushing, and sieving through 40 mesh to obtain Flammulina velutipes fiber (water content of 6.5wt%); S3, crushing the dried aronia berry, sieving through a 100-mesh sieve, adding 30 times the volume of water, stirring and extracting at 400 rpm at 90° C. for 0.5 h, filtering and concentrating the filtrate to 1 / 5 of the volume, and obtaining an aronia berry extract; S4, crush the dried black tea, sieve through 100 mesh, add 50 times volume of water, stir and extract at 400 rpm at 100°C for 0.5 h, filter and concentrate the filtrate to 1 / 20 volume, and obtain a black tea extract; S5. Mix 90 parts of citrus fruit filtrate, 1 part of Flammulina velutipes fiber, 1 part of soy protein isolate, 5 parts of aronia extract and 3 parts of black tea extract according to their mass proportions, and spray dry them. The spray drying inlet temperature is 220° C. and the outlet temperature is 110° C. to obtain citrus powder.

[0023] S6. Mix 5 parts by mass of probiotics and 90 parts by mass of citrus powder to obtain a citrus powder composition (with a water content of 5.7 wt %).

[0024] The composition containing citrus polyphenols and citrus powder is used to prepare tablets, and 5 parts by mass of carboxymethyl cellulose is added. After granulation, the tablets are pressed to prepare tablets with a mass of 0.2 g / tablet of the composition containing citrus powder.

[0025] Example 2 A composition containing citrus polyphenols and citrus powder for burning fat and losing weight, comprising, by weight, 90 parts of citrus powder and 1 part of composite probiotics (1*10^8 cfu / g).

[0026] The preparation method of the citrus powder composition is as follows: S1. Crush and homogenize the citrus fruits with skin, and filter to obtain citrus fruit filtrate; S2, adding 5 times volume of water to fresh Flammulina velutipes, stirring and extracting at 200 rpm at 90°C for 1 hour, filtering through 400 mesh, washing with 10 times volume of water, filtering through 400 mesh to obtain solids, drying at 45°C to obtain Flammulina velutipes crude fiber, crushing, and sieving through 20 mesh to obtain Flammulina velutipes fiber (water content of 6.6wt%); S3, crushing the dried aronia berry, sieving through a 200-mesh sieve, adding 50 times the volume of water, stirring and extracting at 500 rpm at 80° C. for 1 h, filtering and concentrating the filtrate to 1 / 3 of the volume, and obtaining an aronia berry extract; S4, crush the dried black tea, sieve through 200 mesh, add 30 times volume of water, extract at 80°C and 300 rpm for 1 hour, filter and concentrate the filtrate to 1 / 15 volume, and obtain a black tea extract; S5. Mix 80 parts of citrus fruit filtrate, 2 parts of Flammulina velutipes fiber, 5 parts of soy protein isolate, 8 parts of aronia berry extract and 5 parts of black tea extract according to their mass proportions, and spray dry them. The spray drying inlet temperature is 180°C and the outlet temperature is 105°C to obtain citrus powder (with a water content of 5.7wt%).

[0027] S6. Mix 1 part by mass of probiotics and 90 parts by mass of citrus powder to obtain a citrus powder composition.

[0028] The citrus powder composition is used to prepare tablets, and 9 parts by mass of carboxymethyl cellulose is added. After granulation, the tablets are pressed to prepare tablets containing 0.2 g of the citrus powder composition per tablet.

[0029] Example 3 A composition containing citrus polyphenols and citrus powder for burning fat and losing weight, comprising, by weight, 90 parts of citrus powder and 10 parts of composite probiotics (1*10^8 cfu / g).

[0030] The preparation method of the citrus powder composition is as follows: S1. Crush and homogenize the citrus fruits with skin, and filter to obtain citrus fruit filtrate; S2, adding 5 times volume of water to fresh Flammulina velutipes, stirring and extracting at 100 rpm at 90°C for 1 hour, filtering through 400 mesh, washing with 10 times volume of 10 water, filtering through 400 mesh to obtain solids, drying at 60°C to obtain Flammulina velutipes crude fiber, crushing, and sieving through 20 mesh to obtain Flammulina velutipes fiber (water content of 5.5wt%); S3, crushing the dried aronia berry, sieving through a 200-mesh sieve, adding 50 times the volume of water, stirring and extracting at 300 rpm at 80° C. for 1 h, filtering and concentrating the filtrate to 1 / 3 of the volume, and obtaining an aronia berry extract; S4, crush the dried black tea, sieve through 200 mesh, add 30 times volume of water, extract at 80°C and 200 rpm for 1 hour, filter and concentrate the filtrate to 1 / 10 volume, and obtain a black tea extract; S5. According to the mass proportions, 85 parts of citrus fruit filtrate, 3 parts of Flammulina velutipes fiber, 3 parts of soy protein isolate, 6 parts of chokeberry extract and 3 parts of black tea extract were mixed and stirred, and spray-dried. The spray-drying inlet temperature was 220°C and the outlet temperature was 110°C to obtain citrus powder (with a water content of 5.7wt%).

[0031] S6. Mix 10 parts by mass of probiotics and 90 parts by mass of citrus powder to obtain a citrus powder composition.

[0032] The citrus powder composition is used to prepare tablets, and after granulation, tablets are pressed to prepare tablets containing the citrus powder composition in a mass of 0.2 g / tablet.

[0033] Comparative Example 1 A composition containing citrus polyphenols and citrus powder for burning fat and losing weight, comprising 90 parts by weight of citrus powder.

[0034] The preparation method of the citrus powder composition is as follows: S1. Crush and homogenize the citrus fruits with skin, and filter to obtain citrus fruit filtrate; S2, adding 10 times volume of water to fresh Flammulina velutipes, stirring and extracting at 200 rpm at 80°C for 1 hour, filtering through 400 mesh, washing with 10 times volume of water, filtering through 400 mesh to obtain solids, drying at 45°C to obtain Flammulina velutipes crude fiber, crushing, and sieving through 40 mesh to obtain Flammulina velutipes fiber (water content of 6.6wt%); S3, crushing the dried aronia berry, sieving through a 100-mesh sieve, adding 30 times the volume of water, stirring and extracting at 400 rpm at 90° C. for 0.5 h, filtering and concentrating the filtrate to 1 / 5 of the volume, and obtaining an aronia berry extract; S4, crush the dried black tea, sieve through 100 mesh, add 50 times volume of water, stir and extract at 400 rpm at 100°C for 0.5 h, filter and concentrate the filtrate to 1 / 20 volume, and obtain a black tea extract; S5. Mix 90 parts of citrus fruit filtrate, 1 part of Flammulina velutipes fiber, 1 part of soy protein isolate, 5 parts of chokeberry extract and 3 parts of black tea extract according to their mass proportions, and spray dry them. The spray drying inlet temperature is 220°C and the outlet temperature is 110°C to obtain citrus powder (with a water content of 5.7wt%).

[0035] The citrus powder is used to prepare tablets. 90 parts by mass of citrus powder are added with 10 parts by mass of carboxymethyl cellulose, granulated, and tableted to prepare tablets containing the citrus powder composition with a mass of 0.2 g / tablet.

[0036] Comparative Example 2 A composition containing citrus polyphenols and citrus powder for burning fat and losing weight, comprising, by weight, 90 parts of citrus powder and 5 parts of composite probiotics (1*10^8 cfu / g).

[0037] The preparation method of the citrus powder composition is as follows: S1. Crush and homogenize the citrus fruits with skin, and filter to obtain citrus fruit filtrate; S2, crushing the dried aronia berry, sieving through a 100-mesh sieve, adding 30 times the volume of water, stirring and extracting at 400 rpm at 90° C. for 0.5 h, filtering and concentrating the filtrate to 1 / 5 of the volume, and obtaining an aronia berry extract; S3, crush the dried black tea, sieve through 100 mesh, add 50 times volume of water, stir and extract at 400 rpm at 100°C for 0.5 h, filter and concentrate the filtrate to 1 / 20 volume, and obtain a black tea extract; S4. Mix 90 parts of citrus fruit filtrate, 2 parts of soy protein isolate, 5 parts of chokeberry extract and 3 parts of black tea extract according to their mass proportions, and spray dry them. The spray drying inlet temperature is 220° C. and the outlet temperature is 110° C. to obtain citrus powder.

[0038] S5. Mix 5 parts by mass of probiotics and 90 parts by mass of citrus powder to obtain a citrus powder composition.

[0039] The citrus powder composition was used to prepare tablets, 5 parts by mass of carboxymethyl cellulose was added, and the tablets containing 0.2 g / tablet of the citrus powder composition were prepared through granulation and tablet pressing.

[0040] Comparative Example 3 A composition containing citrus polyphenols and citrus powder for burning fat and losing weight, comprising, by weight, 90 parts of citrus powder and 5 parts of composite probiotics (1*10^8 cfu / g).

[0041] The preparation method of the citrus powder composition is as follows: S1. Crush and homogenize the citrus fruits with skin, and filter to obtain citrus fruit filtrate; S2, adding 10 times volume of water to fresh Flammulina velutipes, stirring and extracting at 200 rpm at 80°C for 1 hour, filtering through 400 mesh, washing with 10 times volume of water, filtering through 400 mesh to obtain solids, drying at 45°C to obtain Flammulina velutipes crude fiber, crushing, and sieving through 40 mesh to obtain Flammulina velutipes fiber (water content ≤ 8wt%); S3, crush the dried black tea, sieve through 100 mesh, add 50 times volume of water, stir and extract at 400 rpm at 100°C for 0.5 h, filter and concentrate the filtrate to obtain a black tea extract; S4. Mix 90 parts of citrus fruit filtrate, 1 part of Flammulina velutipes fiber, 1 part of soy protein isolate, 5 parts of water and 8 parts of black tea extract according to their mass proportions, and spray dry them. The spray drying inlet temperature is 220°C and the outlet temperature is 110°C to obtain citrus powder (with a water content of 5.7wt%).

[0042] S5. Mix 5 parts by mass of probiotics and 90 parts by mass of citrus powder to obtain a citrus powder composition.

[0043] The citrus powder composition is used to prepare tablets, and 5 parts by mass of carboxymethyl cellulose is added. After granulation, the tablets are pressed to prepare tablets containing 0.2 g of the citrus powder composition per tablet.

[0044] Comparative Example 4 A composition containing citrus polyphenols and citrus powder for burning fat and losing weight, comprising, by weight, 90 parts of citrus powder and 5 parts of composite probiotics (1*10^8 cfu / g).

[0045] The preparation method of the citrus powder composition is as follows: S1. Crush and homogenize the citrus fruits with skin, and filter to obtain citrus fruit filtrate; S2, adding 10 times volume of water to fresh Flammulina velutipes, stirring and extracting at 200 rpm at 80°C for 1 hour, filtering through 400 mesh, washing with 10 times volume of water, filtering through 400 mesh to obtain solids, drying at 45°C to obtain Flammulina velutipes crude fiber, crushing, and sieving through 40 mesh to obtain Flammulina velutipes fiber (water content of 6.5wt%); S3, crushing the dried aronia berry, sieving through a 100-mesh sieve, adding 30 times the volume of water, stirring and extracting at 400 rpm at 90° C. for 0.5 h, filtering and concentrating the filtrate to 1 / 5 of the volume, and obtaining an aronia berry extract; S4. Mix 90 parts of citrus fruit filtrate, 1 part of Flammulina velutipes fiber, 1 part of soy protein isolate, 8 parts of aronia berry extract and 3 parts of water according to their mass proportions, and spray dry them. The spray drying inlet temperature is 220°C and the outlet temperature is 110°C to obtain citrus powder (with a water content of 5.7wt%).

[0046] S5. Mix 5 parts by mass of probiotics and 90 parts by mass of citrus powder to obtain a citrus powder composition.

[0047] The citrus powder composition was used to prepare tablets, 5 parts by mass of carboxymethyl cellulose was added, and the tablets containing 0.2 g / tablet of the citrus powder composition were prepared through granulation and tablet pressing.

[0048] Citrus powder ingredient index content test The determination of dietary fiber content in citrus powder refers to GB5009.88-2023 "National Food Safety Standard Determination of Dietary Fiber in Foods", the determination of total polyphenol content refers to GB / T 44349-2024 "Detection of Total Polyphenols in Bee Pollen - Folin Reagent Colorimetric Method", and the determination of Vc content refers to GB 5009.86-2016 "National Food Safety Standard Determination of Ascorbic Acid in Foods".

[0049] Table 1 Indicators of citrus powder composition

[0050] Efficacy Test Experimental method: The blank control group took a placebo, 2 capsules / day; the examples and comparative examples were taken continuously for 8 weeks according to the above method. During the entire experimental period, diet was not controlled, exercise was not deliberately increased, and other weight-loss foods and medicines were prohibited. 80 obese people with body mass index assessment were selected and randomly divided into 8 groups. Before and after the experiment, the InBody human composition analyzer (model 770) was used to test the subjects' weight, body fat percentage, and body mass index, where * indicates a significant difference before and after the experiment (P<0.05), and ** indicates a very significant difference before and after the experiment (P<0.01).

[0051] Table 2 Weight changes of subjects

[0052] Table 3 Changes in body fat of subjects

[0053] The above embodiments are preferred implementation modes of the present invention, but the implementation modes of the present invention are not limited to the above embodiments. Any other changes, modifications, substitutions, combinations, and simplifications that do not deviate from the spirit and principles of the present invention should be equivalent replacement methods and are included in the protection scope of the present invention.

Claims

1. A composition containing citrus polyphenols and citrus powder for burning fat and losing weight, characterized in that: Includes citrus powder, probiotics; The citrus powder comprises, by weight, 80-90 parts of citrus fruit filtrate, 5-8 parts of aronia extract, 2-5 parts of black tea extract, 1-2 parts of enoki mushroom fiber, and 1-5 parts of soy protein isolate.

2. The composition containing citrus polyphenols and citrus powder according to claim 1, characterized in that: The citrus fruit filtrate is prepared by taking citrus fruits with skin as raw materials.

3. The composition containing citrus polyphenols and citrus powder according to claim 1, characterized in that: Calculated by mass fraction, the dietary fiber content of the citrus powder is ≥40%, the total polyphenol content is ≥5%, and the VC content is ≥2%.

4. The composition containing citrus polyphenols and citrus powder according to claim 1, characterized in that: The caffeine content of the black tea extract is ≥0.5%.

5. The composition containing citrus polyphenols and citrus powder according to claim 1, characterized in that: The probiotics are composite probiotics, and the composite probiotics include Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium lactis and Lactobacillus casei.

6. A method for preparing a composition containing citrus polyphenols and citrus powder for burning fat and losing weight according to any one of claims 1 to 5, characterized in that: The following steps are involved: S1. Crush and homogenize the citrus fruits with skin, and filter to obtain citrus fruit filtrate; S2, adding 5-10 times volume of water to fresh Flammulina velutipes, extracting at 80-90°C, filtering, washing, separating, drying to obtain Flammulina velutipes crude fiber, crushing, and sieving through 20-40 mesh to obtain Flammulina velutipes fiber; S3, crushing the dried aronia berry, sieving through a 100-200 mesh, adding 30-50 times volume of water, extracting at 70-90° C. for 0.5-1 h, filtering and concentrating the filtrate to 1 / 3-1 / 5 volume, to obtain an aronia berry extract; S4, crushing the dried black tea, sieving through a 100-200 mesh, adding 30-50 times volume of water, extracting at 80-100° C. for 0.5-1 h, filtering and concentrating the filtrate to obtain a black tea extract; S5, mixing the citrus fruit filtrate, Flammulina velutipes fiber, soy protein isolate, aronia berry extract, and black tea extract, and spray drying the mixture to obtain citrus powder; S6. Mix the probiotics and citrus powder to obtain a citrus powder composition.

7. The method for preparing a composition containing citrus polyphenols and citrus powder for burning fat and losing weight according to claim 6, characterized in that: The spray drying has an inlet temperature of 180-220°C and an outlet temperature of 105-110°C.

8. The use of a composition containing citrus polyphenols and citrus powder for burning fat and losing weight according to any one of claims 1 to 5, characterized in that: Used to prepare weight loss and fat reduction products.

9. Use of a composition containing citrus polyphenols and citrus powder for burning fat and losing weight prepared by the preparation method according to any one of claims 6 to 7, characterized in that: Used to prepare weight loss and fat reduction products.

10. The use according to claim 8 or 9, characterized in that: Weight loss and fat reduction products include medicines or health products.

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