An esophageal precise drug applicator

Abstract

The present invention relates to the technical field of esophageal drug delivery devices, and specifically provides an esophageal precise drug applicator, which includes an external catheter. One end of the external catheter is connected to a holding handle, and the other end of the external catheter is connected to a drug delivery tube through a cylindrical synovial membrane. The end of the drug delivery tube is provided with a drug delivery nozzle. The cylindrical synovial membrane wraps the drug delivery tube and separates the esophagus from the drug delivery tube, so that when the drug delivery tube moves in the esophagus, it does not rub against the internal mucosa of the esophagus, but gradually fits the cylindrical synovial membrane to the inside of the esophagus. The cylindrical synovial membrane that fits inside the esophagus is relatively stationary with the inside of the esophagus. By moving the drug delivery tube relative to the inside of the cylindrical synovial membrane, the drug delivery tube can reach the designated position. When the drug delivery tube moves to the diseased position, the drug delivery nozzle can be controlled to spray the liquid medicine, reducing the discomfort of the patient and avoiding affecting the precision of drug delivery.

Description

Technical Field

[0001] The present invention relates to the technical field of esophageal drug delivery devices, and particularly to an esophageal precise drug applicator. Background Art

[0002] An esophageal drug delivery device generally refers to a medical device such as an endoscope that precisely delivers drugs to a certain part of the esophagus. It is mostly used for treating esophageal diseases, such as esophageal cancer, esophageal ulcers, etc. Generally speaking, the drugs can be anti-cancer drugs, antibacterial drugs, or anti-inflammatory drugs for local treatment. The device can be guided by an endoscope to accurately deliver the drug to the part that needs treatment. Using an endoscope for operation can minimize the damage to surrounding tissues and improve the efficacy and safety of the drug.

[0003] For example, Chinese Patent CN221905315U discloses an esophageal drug delivery device. The solution includes a drug outlet hole opened on the outer wall of the drug delivery tube and a syringe detachably connected to the drug delivery tube. The head end of the drug delivery tube is connected with a connector, and the connector is threadedly connected with the drug outlet nozzle of the syringe. The tail end of the drug delivery tube is connected with an airbag for blocking the esophagus. One side of the airbag close to the drug outlet hole is connected with an air charging tube, and the tail end of the air charging tube extends to the outside of the syringe. In this solution, by providing an airbag on the drug delivery tube, when the drug is sprayed onto the affected area of the inner wall of the esophagus along the drug outlet hole, the airbag is inflated through the air charging tube to bulge and fit with the inner wall of the esophagus, so that the affected area of the esophagus can absorb the drug.

[0004] However, when the drug delivery tube in the above solution enters the esophagus, it is inevitable to rub against the inner mucosa of the esophagus, which is likely to cause discomfort to the patient, affect the drug delivery operation, and seriously damage the inner mucosa of the esophagus and aggravate the patient's condition. Summary of the Invention

[0005] Based on this, in view of the problem that the current esophageal drug delivery device is prone to rub against the inner mucosa of the esophagus during drug delivery, it is necessary to provide an esophageal precise drug applicator.

[0006] The above object is achieved by the following technical solutions:

[0007] A precise esophageal medication device comprises an external catheter, one end of which is connected to a gripping handle, the other end of which is coaxially connected to a medication tube, the medication tube is communicated with the external catheter, a plurality of medication nozzles are arranged at the end of the medication tube, the medication tube can extend into the esophagus, a cylindrical synovial membrane is connected between the medication tube and the external catheter, one end of the cylindrical synovial membrane is fixedly connected to the external catheter, the other end of the cylindrical synovial membrane passes through the outer periphery of the medication tube, passes the end of the medication tube and is fixed to the medication tube after forming a plurality of folds, a sealed cavity is formed between the cylindrical synovial membrane and the outer wall of the medication tube, the increase in air pressure inside the sealed cavity can push the medication tube forward in the esophagus and expand the folds of the cylindrical synovial membrane.

[0008] Furthermore, the external catheter is connected to an external fixing plate at one end close to the drug administration tube, and the external fixing plate can prevent the external catheter from entering the esophagus. A connecting tube is provided in the middle of the external fixing plate, one end of the connecting tube is coaxial with the external catheter and fixedly connected, and the other end of the connecting tube is sealed and connected to the tubular synovial membrane.

[0009] Furthermore, an air inlet and an air outlet are provided on the side wall of the connecting tube, and both the air inlet and the air outlet are connected to the sealed cavity. Gas enters the sealed cavity through the air inlet to increase the air pressure inside the sealed cavity. When the air pressure inside the sealed cavity exceeds a preset value, the air outlet opens.

[0010] Furthermore, a regulating valve core is provided on the air vent, and the regulating valve core can adjust the air pressure required when the air vent is opened. The regulating valve core includes a first adjusting screw, and an elastic member is provided on the end of the first adjusting screw. A blocking ball is fixedly provided on the other end of the elastic member, and the blocking ball blocks the air vent.

[0011] Furthermore, a support frame is coaxially arranged on the dosing tube near the end, and a sealing ring is arranged on the support frame near the end of the dosing tube. The cylindrical synovial membrane passes through the outer periphery of the support frame and bypasses the sealing ring to be sealed and connected to the inside of the support frame. The pleated part is located between the support frame and the dosing tube.

[0012] Furthermore, the support frame includes a support ring and a plurality of grab bars, the support ring is connected to the outer periphery of the drug delivery tube, the plurality of grab bars are evenly distributed circumferentially on the support ring and are all hingedly arranged, the sealing ring is abutted against the outer wall of the end of the drug delivery tube by the plurality of grab bars, and a torsion spring is arranged at the hinge position of the plurality of grab bars and the support ring, the torsion spring enables the other end of the plurality of grab bars to abut against the sealing ring, and the sealing ring abuts a part of the cylindrical synovial membrane against the outer wall of the end of the drug delivery tube.

[0013] Furthermore, an adjusting assembly is provided on the drug delivery tube. The adjusting assembly can adjust the abutting force of the sealing ring against the tubular synovial membrane, and the advancing speed of the drug delivery tube inside the esophagus is negatively correlated with the abutting force of the sealing ring against the tubular synovial membrane.

[0014] Furthermore, the adjusting assembly includes a fixed ring sleeve and a limiting ring sleeve. The fixed ring sleeve is coaxially and fixedly arranged on the outer periphery of the drug delivery tube. The limiting ring sleeve is coaxially and fixedly sleeved on the outer periphery of the fixed ring sleeve. The support ring of the support frame is slidably arranged on the fixed ring sleeve and is located above the limiting ring sleeve. The support ring can move axially along the fixed ring sleeve. The outer periphery of the end of the drug delivery tube is a conical surface with the small end facing downwards. The sealing ring abuts the tubular synovial membrane against the conical surface. The axial movement of the support ring along the fixed ring sleeve can drive the sealing ring to move axially on the conical surface.

[0015] Furthermore, a convex ring is coaxially and fixedly arranged on the outer periphery of the fixed ring sleeve. A second adjusting screw is axially threadedly connected to the end face of the convex ring. The other end of the second adjusting screw is rotatably connected to the end face of the support ring. The rotation of the second adjusting screw can drive the support ring to move axially along the fixed ring sleeve.

[0016] Furthermore, a camera and a clamp are arranged inside the end of the drug delivery tube.

[0017] The beneficial effects of the present invention are as follows:

[0018] By providing the tubular synovial membrane, the present invention separates the esophagus and the drug delivery tube, so that when the drug delivery tube moves in the esophagus, it does not rub against the inner mucosa of the esophagus. Instead, the tubular synovial membrane is gradually attached to the inside of the esophagus. The tubular synovial membrane attached to the inside of the esophagus is relatively stationary with respect to the inside of the esophagus. The drug delivery tube can reach the designated position by moving relative to the inside of the tubular synovial membrane. Moreover, lubricating oil is also applied to the outer periphery of the tubular synovial membrane, so it can also avoid damaging the esophagus when the tubular synovial membrane adheres to the inside of the esophagus. When the drug delivery tube moves to the diseased position, the drug spraying nozzle can be controlled to spray the liquid medicine, reducing the discomfort of the patient and avoiding affecting the accuracy of drug administration.

[0019] By providing the air release port, the present invention can avoid the sudden change in the shape of the tubular synovial membrane caused by excessive pressure in the sealed cavity, thereby avoiding damage to the esophagus by the tubular synovial membrane.

[0020] By providing the regulating valve core, the present invention can adjust the air pressure value required for the air release port to release air, and further can be adjusted according to the different inner diameters of the patient's esophagus, improving the applicable range of the esophageal precise drug applicator.

[0021] By providing the adjusting assembly, the adjusting assembly can adjust the moving speed of the drug delivery tube in the esophagus, and further can improve the efficiency and accuracy of drug administration of the drug delivery tube. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 A schematic diagram of the structure of an esophageal precision medicine dispenser provided in one embodiment of the present invention;

[0023] Figure 2 This is an exploded view of the esophageal precision medicine dispenser provided by one embodiment of the present invention without the external catheter and the holding handle;

[0024] Figure 3 A schematic diagram of the structure of the esophageal precise medicine dispenser provided by one embodiment of the present invention from another angle;

[0025] Figure 4 for Figure 3 A cross-sectional view of the esophageal precision medicine dispenser along AA provided in one embodiment;

[0026] Figure 5 for Figure 4 A partial enlarged view of part X of the esophageal precise medication delivery device provided in the first embodiment;

[0027] Figure 6 A schematic diagram of the structure of the esophageal precise medication dispenser provided by one embodiment of the present invention from another angle;

[0028] Figure 7 for Figure 6 A cross-sectional view of the esophageal precision medicine dispenser provided in an embodiment of the present invention along the BB;

[0029] Figure 8 for Figure 7 A partial enlarged view of the Y portion of the esophageal precision medicine dispenser provided in the first embodiment;

[0030] Figure 9 for Figure 8 A partial enlarged view of the esophageal precise medication delivery device U provided in the first embodiment;

[0031] Figure 10 for Figure 8 A partial enlarged view of part V of the esophageal precise medication delivery device provided in the first embodiment;

[0032] Figure 11 for Figure 8 A partial enlarged view of the esophageal precise medicine delivery device W provided in the first embodiment;

[0033] Figure 12 An axonometric view of a cutaway support ring of an esophageal precision medicine dispenser provided in one embodiment of the present invention;

[0034] Figure 13 A schematic diagram of the structure of a single grab bar of the esophageal precision medicine dispenser provided in one embodiment of the present invention.

[0035] in:

[0036] 100, Holding handle; 110, Liquid medicine cylinder; 120, External catheter; 130, First annular groove; 140, First sealing washer; 150, External fixing plate; 151, Connecting cylinder; 160, Air inlet; 161, Valve ball; 170, Air release port; 171, First adjusting screw; 172, Blocking ball; 173, Elastic member;

[0037] 200, Cylindrical synovium; 201, Folding part; 210, Administration tube; 211, Administration nozzle; 212, Conical surface; 220, Support ring; 221, Hinge groove; 222, First fixing groove; 223, Hinge column; 224, Second annular groove; 225, Second sealing washer; 230, Grabbing rod; 231, Fitting groove; 232, Second fixing groove; 233, Grabbing hook; 240, Torsion spring; 250, Sealing ring; 260, Sealing cavity;

[0038] 300, Fixed ring sleeve; 310, Limiting ring sleeve; 320, Convex ring; 330, Second adjusting screw; 340, Rotating ring;

[0039] 400, Camera; 410, Clamp. Detailed implementation manners

[0040] In order to make the objectives, technical solutions and advantages of the present invention clearer and more understandable, the present invention will be further described in detail below through embodiments and in conjunction with the accompanying drawings. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0041] The serial numbers assigned to the components herein, such as "first", "second", etc., are only used to distinguish the described objects and do not have any sequential or technical meanings. The "connection" and "coupling" mentioned in the present invention, unless otherwise specified, both include direct and indirect connections (couplings). In the description of the present invention, it should be understood that the orientation or positional relationships indicated by the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc. are based on the orientation or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be construed as a limitation to the present invention.

[0042] In the present invention, unless otherwise clearly specified or limited, the first feature being "on" or "under" the second feature may mean that the first and second features are in direct contact, or the first and second features are indirectly in contact through an intermediate medium. Moreover, the first feature being "above", "over" and "on top of" the second feature may mean that the first feature is directly above or obliquely above the second feature, or merely indicates that the horizontal height of the first feature is higher than that of the second feature. The first feature being "under", "beneath" and "underneath" the second feature may mean that the first feature is directly below or obliquely below the second feature, or merely indicates that the horizontal height of the first feature is lower than that of the second feature.

[0043] The following will refer to Figures 1 - 13 to describe an esophageal precise medicine applicator provided by the present invention.

[0044] An esophageal precise medicine applicator, which is applicable to the treatment of esophageal diseases, includes an external catheter 120. One end of the external catheter 120 is connected with a holding handle 100 for an operator to hold. The other end of the external catheter 120 is coaxially connected with a medicine delivery tube 210. The medicine delivery tube 210 is communicated with the external catheter 120. A plurality of medicine spraying nozzles 211 are arranged at the end of the medicine delivery tube 210. The external catheter 120 conveys the liquid medicine to the medicine delivery tube 210, and the liquid medicine sprays out from the plurality of medicine spraying nozzles 211. When the medicine delivery tube 210 reaches the internal lesion position of the esophagus, the operator conveys the liquid medicine by controlling the holding handle 100, so that the liquid medicine can be accurately sprayed on the lesion position to complete the medicine application operation.

[0045] In the prior art, generally, the drug delivery tube 210 and the external catheter 120 are inserted into the patient's esophagus together, and lubricating oil is also applied to the outer peripheries of the external catheter 120 and the drug delivery tube 210. However, when the external catheter 120 and the drug delivery tube 210 are inserted into the esophagus together and friction occurs, even with the application of lubricating oil, it will cause discomfort to the patient and thus affect the accuracy of the drug administration operation. In the present invention, a cylindrical synovial membrane 200 is connected between the external catheter 120 and the drug delivery tube 210. One end of the cylindrical synovial membrane 200 is connected to one end of the external catheter 120 close to the drug delivery tube 210, and the other end of the cylindrical synovial membrane 200 passes through the outer periphery of the drug delivery tube 210, that is, wraps the outer periphery of the drug delivery tube 210. Subsequently, the other end of the cylindrical synovial membrane 200 will pass through the end of the outer periphery of the drug delivery tube 210 and form a plurality of folds, that is, there is a folding part 201, and then it is fixed on the drug delivery tube 210. At this time, there is a sealed cavity 260 between the cylindrical synovial membrane 200 and the drug delivery tube 210. The outer periphery of the cylindrical synovial membrane 200 is also coated with lubricating oil, and when the air pressure in the sealed cavity 260 increases, it can push the drug delivery tube 210 to move forward in the esophagus. The cylindrical synovial membrane 200 fits with the inner part of the esophagus and does not produce relative movement. During the forward movement of the drug delivery tube 210, the folding part 201 of the cylindrical synovial membrane 200 is gradually stretched, so as to continuously attach the cylindrical synovial membrane 200 of the folding part 201 to the inner part of the esophagus, preventing friction between the drug delivery tube 210 and the inner part of the esophagus.

[0046] Through the above setting of the cylindrical synovial membrane 200, the esophagus and the drug delivery tube 210 are separated, so that when the drug delivery tube 210 moves in the esophagus, it does not rub against the inner mucosa of the esophagus, but gradually attaches the cylindrical synovial membrane 200 to the inner part of the esophagus. The cylindrical synovial membrane 200 attached to the inner part of the esophagus is relatively stationary with the inner part of the esophagus. The drug delivery tube 210 moves relative to the inside of the cylindrical synovial membrane 200 so that the drug delivery tube 210 can reach the designated position. Moreover, the outer periphery of the cylindrical synovial membrane 200 is also coated with lubricating oil, so it can also avoid damaging the esophagus when the cylindrical synovial membrane 200 fits with the inner part of the esophagus. When the drug delivery tube 210 moves to the diseased position, the drug spraying nozzle 211 can be controlled to spray the liquid medicine, reducing the discomfort of the patient and avoiding affecting the accuracy of drug administration.

[0047] Specifically, an external fixing plate 150 is connected to one end of the external catheter 120 close to the drug delivery tube 210. The external fixing plate 150 is used to prevent the external catheter 120 from entering the esophagus. As Figure 8 and Figure 9 shown, there is a connecting cylinder 151 in the middle of the external fixing plate 150. One end of the connecting cylinder 151 is coaxially and fixedly connected to one end of the external catheter 120 close to the drug delivery tube 210, and the other end of the connecting cylinder 151 is hermetically connected to one end of the cylindrical synovial membrane 200, specifically hermetically connected through a first sealing gasket 140. As Figure 9As shown, a first annular groove 130 is formed at one end of the connecting cylinder 151 close to the cylindrical synovial membrane 200. One end of the cylindrical synovial membrane 200 is located within the first annular groove 130, and the first sealing washer 140 tightly abuts one end of the cylindrical synovial membrane 200 within the first annular groove 130, thus playing a role in sealed connection.

[0048] More specifically, as Figure 8 and Figure 9 shown, an air inlet 160 and a vent 170 are formed in the side wall of the connecting cylinder 151. The air inlet 160 is used to convey gas into the sealed cavity 260. The gas entering the sealed cavity 260 can increase the air pressure within the sealed cavity 260, and thus can push the drug delivery tube 210 to advance inside the esophagus. The vent 170 is used to prevent the air pressure within the sealed cavity 260 from being too high, which may cause the shape of the cylindrical synovial membrane 200 to mutate, and thus avoid damaging the mucosa inside the esophagus.

[0049] It can be understood that when the air pressure within the sealed cavity 260 reaches a certain value, it can push the drug delivery tube 210 to advance inside the esophagus. Therefore, the limit value (preset value) is set to be slightly greater than the air pressure required to push the drug delivery tube 210 to advance. When the air pressure value within the sealed cavity 260 is greater than the limit value, the vent 170 will open to prevent the air pressure within the sealed cavity 260 from being too high.

[0050] It should be noted that the air inlet 160 of the present invention can only intake air unidirectionally and cannot release air outward. As Figure 9 shown, a valve ball 161 is arranged within the air inlet 160. A compression spring is connected to the bottom of the valve ball 161. One end of the compression spring abuts against the inner part of the lower end of the air inlet 160. In the initial state, the valve ball 161 seals the upper end of the air inlet 160 through the compression spring. Only when air is inflated into the air inlet 160 and the air pressure increases to be able to overcome the compression spring, the valve ball 161 moves downward to open the air inlet 160, and the gas can enter the sealed cavity 260 through the air inlet 160. Through the unidirectional air intake setting, the gas pressure entering the sealed chamber is constant, and the gas input process is relatively stable.

[0051] Specifically, the air inlet 160 in this embodiment is connected to a micro air pump (not shown in the figure), and the micro air pump is used to convey gas into the sealed chamber.

[0052] In a further embodiment, in order to increase the applicable range of the esophageal precise drug applicator, a regulating valve core is provided on the air release port 170. The regulating valve core can adjust the air pressure required to open the air release port 170, that is, it can adjust the limit value of the sealed cavity 260. Since the inner diameters of the esophagi of different patients are different, some patients have a smaller esophageal inner diameter, while some patients have a larger esophageal inner diameter. Therefore, the regulating valve core can be used to change the limit value of the sealed cavity 260 to adapt to esophagi with different inner diameters, thereby increasing the applicable range of the esophageal precise drug applicator.

[0053] Specifically, as Figure 8 and Figure 9 shown, the regulating valve core includes a first adjusting screw 171. The first adjusting screw 171 is helically connected to the outside of the air release port 170. The bottom end of the first adjusting screw 171 is connected with an elastic member 173. The elastic member 173 can be a compression spring. The other end of the elastic member 173 is fixedly connected with a blocking ball 172. The blocking ball 172 blocks the air release port 170. When the gas pressure in the sealed cavity 260 can overcome the elastic force of the elastic member 173, the blocking ball 172 can be pushed to open the air release port 170. By rotating the first adjusting screw 171, the compression degree of the elastic member 173 can be adjusted. When the compression degree of the elastic member 173 is larger, the limit value of the sealed cavity 260 is larger. When the air pressure in the sealed cavity 260 exceeds the larger limit value, the blocking ball 172 can be pushed to open the air release port 170. Similarly, when the compression degree of the elastic member 173 is smaller, the limit value of the sealed cavity 260 is smaller. Only when the air pressure in the sealed cavity 260 exceeds the smaller limit value can the blocking ball 172 be pushed to open the air release port 170. It should be noted that the minimum limit value also needs to be greater than the pressure value required to push the drug delivery tube 210 to advance in the esophagus, so as to avoid the phenomenon that gas directly discharges from the air release port 170 and the drug delivery tube 210 cannot advance in the esophagus.

[0054] Specifically, a support frame is coaxially arranged at a position near the end of the drug delivery tube 210. A sealing ring 250 is connected to the support frame near the end of the drug delivery tube 210. The sealing ring 250 abuts against the end of the drug delivery tube 210. As Figure 8 and Figure 11 shown, the cylindrical synovial membrane 200 passes through the outer periphery of the support frame and then passes through the sealing ring 250, and is abutted by the sealing ring 250 on the outer periphery of the end of the drug delivery tube 210. The folded part 201 of the cylindrical synovial membrane 200 is formed after passing through the sealing ring 250. By folding the cylindrical synovial membrane 200, more cylindrical synovial membrane 200 can be stored in the space between the sealing ring 250 and the support frame, so that the drug delivery tube 210 can move a longer distance in the esophagus.

[0055] More specifically, in this embodiment, the support frame includes a support ring 220 and a plurality of grasping rods 230. AsFigure 2 , Figure 10 , Figure 12 and Figure 13 As shown in Figure 2 , Figure 10 , Figure 12 and Figure 13 , the support ring 220 is connected to the outer periphery of the drug delivery tube 210. A plurality of gripping rods 230 are circumferentially and uniformly arranged on the support ring 220 and are all hingedly arranged. A torsion spring 240 is arranged at the position where the plurality of gripping rods 230 are hinged to the support ring 220. The torsion spring 240 can make the other ends of the plurality of gripping rods 230 approach each other. And the other ends of the plurality of gripping rods 230 are provided with hooks 233. The hooks 233 abut against the sealing ring 250. By the arrangement of the torsion spring 240, the hooks 233 can always abut against the sealing ring 250, and the sealing ring 250 always abuts the tubular synovium 200 against the outer periphery of the end of the drug delivery tube 210, thereby giving a certain frictional force to the tubular synovium 200. When the air pressure in the sealed cavity 260 increases, the gas pushes the drug delivery tube 210 to advance in the esophagus, and the sealing ring 250 moves synchronously with the drug delivery tube 210. Since the external catheter 120 is externally positioned, the external catheter 120 does not move. Only the drug delivery tube 210 advances in the esophagus. Therefore, during the advancement of the drug delivery tube 210, it can pull the folded portion 201 of the tubular synovium 200 through the sealing ring 250, and through the sealing ring 250 to give a certain frictional force, so that the tubular synovium 200 on the outer periphery of the drug delivery tube 210 is straightened, and at the same time, the length of the tubular synovium 200 on the outer periphery of the drug delivery tube 210 increases. That is to say, the tubular synovium 200 on the outer periphery of the drug delivery tube 210 gradually adheres to the inner wall relative to the inner wall of the esophagus, and the two do not produce relative movement, thereby reducing the discomfort of the patient.

[0056] To facilitate the sealing of the other end of the tubular synovium 200, the other end of the tubular synovium 200 is hermetically connected to the support ring 220. As shown in Figure 10 , a second annular groove 224 is opened at an internal position near the hinge of the plurality of gripping rods 230 on the sealing ring 250, and the other end of the tubular synovium 200 is located in the second annular groove 224, and a second sealing gasket 225 is clamped in the second annular groove 224. The second sealing gasket 225 tightly connects the other end of the tubular synovium 200 in the second annular groove 224.

[0057] Specifically, to facilitate the connection of the torsion spring 240, as shown in Figure 2 , Figure 12 and Figure 13As shown, a hinge groove 221 is formed on the support ring 220. An articulated column 223 is arranged in the hinge groove 221. A first fixing groove 222 is also arranged near the articulated column 223. A mating groove 231 is formed on the gripping rod 230. The mating groove 231 is rotatably connected to the articulated column 223 in the hinge groove 221. A second fixing groove 232 is arranged in the mating groove 231. Both ends of the torsion spring 240 are fixedly connected in the first fixing groove 222 and the second fixing groove 232 respectively, thereby connecting the torsion spring 240 at the articulated positions of multiple gripping rods 230.

[0058] In a further embodiment, to adjust the moving speed of the drug delivery tube 210 in the esophagus to improve the drug delivery efficiency and accuracy, an adjusting assembly is provided on the drug delivery tube 210. The adjusting assembly is used to adjust the abutting force of the sealing ring 250 against the tubular synovium 200, thereby adjusting the frictional force of the sealing ring 250 on the tubular synovium 200. Since the drug delivery tube 210 needs to expand the tubular synovium 200 of the folded part 201 when being pushed by gas, and this part of the tubular synovium 200 needs to pass through the sealing ring 250, and the sealing ring 250 abuts against the tubular synovium 200, when the frictional force between the sealing ring 250 and the tubular synovium 200 is different, the advancing speed of the drug delivery tube 210 in the esophagus is different. That is, the acting force for pushing the drug delivery tube 210 to move by gas does not change, but the drug delivery tube 210 receives different acting forces from the tubular synovium 200, thereby changing the moving speed of the drug delivery tube 210. And the advancing speed of the drug delivery tube 210 inside the esophagus is negatively correlated with the abutting force of the sealing ring 250 against the tubular synovium 200. That is to say, the greater the abutting force of the sealing ring 250 against the tubular synovium 200, the greater the frictional force of the sealing ring 250 on the tubular synovium 200, the greater the resistance received by the drug delivery tube 210 when advancing in the esophagus, and the slower the advancing speed of the drug delivery tube 210 in the esophagus; similarly, the smaller the abutting force of the sealing ring 250 against the tubular synovium 200, the smaller the frictional force of the sealing ring 250 on the tubular synovium 200, the smaller the resistance received by the drug delivery tube 210 when advancing inside the esophagus, and the faster the advancing speed of the drug delivery tube 210 in the esophagus.

[0059] Specifically, the adjustment assembly includes a fixed collar 300 and a limit collar 310. The fixed collar 300 is coaxially and fixedly arranged on the outer periphery of the drug delivery tube 210. The support ring 220 of the support frame is slidably sleeved on the outer periphery of the fixed collar 300. The support ring 220 can move axially along the outer periphery of the fixed collar 300. The limit collar 310 is coaxially and fixedly arranged on the outer periphery of the fixed collar 300 and is located below the support ring 220 to limit the maximum distance of the axial downward movement of the support ring 220 and prevent the support ring 220 from detaching from the fixed collar 300. A convex ring 320 is coaxially and fixedly connected to the upper end of the outer periphery of the fixed collar 300. The convex ring 320 can limit the maximum distance of the axial upward movement of the support ring 220. A second adjustment screw 330 is threadedly connected to the outer peripheral end face of the convex ring 320. The other end of the second adjustment screw 330 is rotatably connected to the support ring 220, specifically connected to the support ring 220 through a rotating ring 340. When the second adjustment screw 330 rotates, it can adjust the axial position of the support ring 220 on the fixed collar 300. In this embodiment, the outer wall of the end of the drug delivery tube 210 is a conical surface 212 with the small end facing downward. Therefore, when the support ring 220 moves axially upward on the fixed collar 300, it can synchronously drive a plurality of grasping rods 230 to move upward synchronously. The hooks 233 on the plurality of grasping rods 230 drive the sealing ring 250 to move upward on the conical surface 212. The sealing ring 250 in this embodiment has elasticity. When the sealing ring 250 moves upward on the conical surface 212, it undergoes elastic deformation, thereby increasing the abutting force on the tubular synovium 200. The frictional force received by the tubular synovium 200 increases, and further slows down the moving speed of the drug delivery tube 210 in the esophagus. Similarly, when the support ring 220 moves axially downward on the fixed collar 300, it drives the plurality of grasping rods 230 to move downward. At this time, the sealing ring 250 moves downward under the action of its own elasticity. The frictional force of the sealing ring 250 on the tubular synovium 200 decreases, so that the moving speed of the drug delivery tube 210 in the esophagus can be increased.

[0060] In a further embodiment, in order to observe the condition of the internal mucosa of the esophagus when the drug delivery tube 210 moves in the esophagus, a camera 400 is further provided at the end of the drug delivery tube 210. The camera 400 can record the condition of the internal mucosa of the esophagus.

[0061] Specifically, a clamp 410 is further provided at the end of the drug delivery tube 210. The clamp 410 is used for sampling. If other lesions appear in the internal mucosa of the esophagus, the clamp 410 can be used to clamp a part of the tissue in the lesion area. After taking out this part of the tissue and performing a test, the cause of the lesion can be known.

[0062] More specifically, a medicine liquid cartridge 110 is connected to the gripping handle 100, and the medicine liquid cartridge 110 is communicated with an external conduit 120. A micro pump (not shown in the figure) is provided in the medicine liquid cartridge 110, and the micro pump can deliver the medicine liquid in the medicine liquid cartridge 110 into the external conduit 120. The medicine liquid enters the dosing tube 210 through the external conduit 120, and is then sprayed out from the dosing nozzle 211 through the dosing tube 210.

[0063] The specific working process of the esophageal precise medicine dispenser provided by the present invention is described in combination with the above embodiments:

[0064] When the dosing tube 210 has not entered the esophagus initially, the dosing tube 210 and the external catheter 120 are very close to each other, the cylindrical synovial membrane 200 between the dosing tube 210 and the external catheter 120 is relatively short, and most of the cylindrical synovial membrane 200 is folded between the multiple grab bars 230 and the dosing tube 210. Before applying the medicine into the esophagus, lubricating oil is applied to the outer periphery of the cylindrical synovial membrane 200, and then the dosing tube 210 is inserted into the esophagus from the patient's mouth. The external fixing plate 150 on the external catheter 120 is fixed through the patient's mouth, and the first adjusting screw 171 is rotated according to the inner diameter of the patient's esophagus to adjust the air pressure required for the deflation of the deflation port 170, and the friction of the sealing ring 250 on the cylindrical synovial membrane 200 is adjusted according to the patient's condition to adjust the forward speed of the dosing tube 210 in the esophagus.

[0065] Start the micro air pump (not shown in the figure), which delivers gas to the air inlet 160. The gas pressure in the sealed cavity 260 gradually increases, thereby pushing the drug delivery tube 210 forward in the esophagus, and in the process of moving forward, the folded cylindrical synovial membrane 200 is stretched open so as to fit inside the esophagus, so that the inside of the esophagus and the cylindrical synovial membrane 200 are relatively still, while the drug delivery tube 210 moves relative to the cylindrical synovial membrane 200, and the drug delivery tube 210 is separated from the inside of the esophagus by the cylindrical synovial membrane 200, thereby reducing the discomfort caused to the patient by the movement of the drug delivery tube 210.

[0066] When the dosing tube 210 moves forward in the esophagus, the camera 400 can be used to observe the situation inside the esophagus. When it reaches the medication area, the operator injects liquid medicine into the dosing tube 210 through the external catheter 120, and the liquid medicine is sprayed out through the dosing nozzle 211 at the end of the dosing tube 210. If other diseased areas are encountered, the clamp 410 can be used to clamp part of the tissue in other diseased areas and remove this part of the tissue for laboratory analysis to determine the cause of the disease, and other drugs can be used to treat the diseased area.

[0067] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0068] The above-described embodiments merely represent several implementation manners of the present invention. The description thereof is relatively specific and detailed, but it should not be construed as a limitation to the scope of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present invention, several variations and improvements can still be made, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the appended claims.

Claims

1. An esophageal precise drug applicator, characterized in that, It includes an external catheter, one end of which is connected to a holding handle, the other end of which is coaxially connected to a drug delivery tube, the drug delivery tube is communicated with the external catheter, a plurality of drug delivery nozzles are arranged at the end of the drug delivery tube, the drug delivery tube can be extended into the esophagus, a cylindrical synovial membrane is connected between the drug delivery tube and the external catheter, one end of the cylindrical synovial membrane is fixedly connected to the external catheter, the other end of the cylindrical synovial membrane passes through the outer periphery of the drug delivery tube, passes the end of the drug delivery tube and is fixed to the drug delivery tube after forming a plurality of folds, a sealed cavity is formed between the cylindrical synovial membrane and the outer wall of the drug delivery tube, the increase in air pressure inside the sealed cavity can push the drug delivery tube forward in the esophagus and expand the folds of the cylindrical synovial membrane, the cylindrical synovial membrane gradually fits inside the esophagus, and the cylindrical synovial membrane fitted inside the esophagus is relatively still with the inside of the esophagus.

2. The esophageal precise drug applicator according to claim 1, characterized in that, An external fixing plate is connected to one end of the external catheter close to the drug delivery tube, and the external fixing plate can prevent the external catheter from entering the esophagus. A connecting tube is provided in the middle of the external fixing plate, one end of the connecting tube is coaxial with the external catheter and fixedly connected, and the other end of the connecting tube is sealingly connected to the tubular synovial membrane.

3. The esophageal precise drug applicator according to claim 2, characterized in that, An air inlet and an air outlet are provided on the side wall of the connecting tube, and both the air inlet and the air outlet are connected to the sealed cavity. Gas enters the sealed cavity through the air inlet to increase the air pressure inside the sealed cavity. When the air pressure in the sealed cavity exceeds a preset value, the air outlet opens.

4. The esophageal precise drug applicator according to claim 3, wherein The air vent is provided with a regulating valve core, which can adjust the air pressure required when the air vent is opened. The regulating valve core includes a first adjusting screw, an elastic member is provided at the end of the first adjusting screw, and a blocking ball is fixedly provided on the other end of the elastic member, and the blocking ball blocks the air vent.

5. The esophageal precise drug applicator according to claim 1, wherein A support frame is coaxially arranged on the dosing tube near the end, and a sealing ring is arranged on the support frame near the end of the dosing tube. The cylindrical synovial membrane passes through the outer periphery of the support frame and bypasses the sealing ring to be sealed and connected inside the support frame. The pleated part is located between the support frame and the dosing tube.

6. The esophageal precise drug applicator according to claim 5, wherein, The support frame includes a support ring and a plurality of grab bars, wherein the support ring is connected to the outer periphery of the drug delivery tube, the plurality of grab bars are evenly distributed circumferentially on the support ring and are all hingedly arranged, the sealing ring is abutted against the outer wall of the end of the drug delivery tube by the plurality of grab bars, and a torsion spring is arranged at the hinge position of the plurality of grab bars and the support ring, the torsion spring enables the other ends of the plurality of grab bars to abut against the sealing ring, and the sealing ring abuts a part of the cylindrical synovial membrane against the outer wall of the end of the drug delivery tube.

7. The esophageal precise drug applicator according to claim 6, characterized in that, The drug delivery tube is provided with an adjustment component, which can adjust the contact force of the sealing ring against the cylindrical synovial membrane. The speed at which the drug delivery tube advances inside the esophagus is negatively correlated with the contact force of the sealing ring against the cylindrical synovial membrane.

8. The esophageal precise drug applicator according to claim 7, characterized in that, The adjusting assembly includes a fixed ring sleeve and a limiting ring sleeve. The fixed ring sleeve is coaxially and fixedly arranged on the outer periphery of the drug delivery tube. The limiting ring sleeve is coaxially and fixedly sleeved on the outer periphery of the fixed ring sleeve. The support ring of the support frame is slidably arranged on the fixed ring sleeve and is located above the limiting ring sleeve. The support ring can move axially along the fixed ring sleeve. The outer periphery of the end of the drug delivery tube is a conical surface with the small end facing downwards. The sealing ring abuts the cylindrical synovial membrane on the conical surface. The axial movement of the support ring along the fixed ring sleeve can drive the sealing ring to move axially on the conical surface.

9. The esophageal precise drug applicator according to claim 8, characterized in that, A convex ring is coaxially and fixedly arranged on the outer periphery of the fixed ring sleeve. A second adjusting screw is axially threadedly connected to the end face of the convex ring. The other end of the second adjusting screw is rotatably connected to the end face of the support ring. The rotation of the second adjusting screw can drive the support ring to move axially along the fixed ring sleeve.

10. The esophageal precise drug applicator according to claim 1, characterized in that, A camera and a clamp are arranged inside the end of the drug delivery tube.

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