Normal-temperature preservation device for isothermal amplification reagent

Abstract

The invention belongs to the technical field of medical treatment and public health, and discloses an isothermal amplification reagent normal-temperature storage device which comprises a shell and further comprises a cover plate arranged on the outer wall of the top end of the shell through a limiting mechanism; the storage box is fixedly connected into the inner wall of the shell; the fixing mechanism is arranged in the inner wall of the storage box through an adjusting assembly; wherein the fixing mechanism comprises a rotating block, the rotating block is elastically connected into the inner wall of the storage box through a volute spiral spring, and the outer wall of the top end of the storage box is fixedly connected with a fixing block; through cooperation of structures such as the rotating block and the clamping plate, the rotating block rotates to drive the clamping plate to move in the inner wall of the guide groove, and when an isothermal amplification reagent is placed in the cavity of the storage box, the clamping plate can clamp and fix the reagent, so that the problem that the reagent is damaged due to shaking during transportation or collision is avoided.

Description

Technical Field

[0001] The invention belongs to the technical field of medical and health care, and in particular is a constant temperature amplification reagent storage device. Background Art

[0002] The constant temperature amplification reagent room temperature storage device is a device specially designed to maintain the stable storage of constant temperature amplification reagents under room temperature conditions. It usually has an intelligent temperature control function, which can accurately keep the internal environmental temperature within a range suitable for the storage of constant temperature amplification reagents, and can effectively prevent the reagents from being contaminated, dried out and impacted, ensuring that the biological activity and performance of the reagents are not affected.

[0003] Some constant temperature amplification reagents are in glass containers, which are directly placed in storage devices during storage. Since the diameters of constant temperature amplification reagents are different, in order to accommodate reagents of different sizes, the cavity in the storage device is set larger to improve adaptability. When placing smaller reagents, this design leaves a certain distance between the reagents and the inner wall of the cavity. When the reagents are transported or collided, the reagents may shake and collide with the inner wall of the cavity, causing damage to the glass reagents. Some existing technologies cannot better fix and protect the reagents. Therefore, a constant temperature storage device for constant temperature amplification reagents is proposed to address the above problems. Summary of the invention

[0004] In order to solve the problems raised in the above background technology, the present invention provides a constant temperature amplification reagent storage device at room temperature, which solves the problem that the reagents in the prior art are easily shaken and damaged during transportation.

[0005] To achieve the above object, the present invention provides the following technical solution: a constant temperature amplification reagent room temperature storage device, comprising a housing, and further comprising:

[0006] A cover plate, the cover plate being arranged on the top outer wall of the shell through a limiting mechanism;

[0007] A storage box, wherein the storage box is fixedly connected to the inner wall of the housing;

[0008] A fixing mechanism, wherein the fixing mechanism is arranged in the inner wall of the storage box through an adjusting component;

[0009] Wherein, the fixing mechanism comprises a rotating block, the rotating block is elastically connected to the inner wall of the storage box through a spiral spring, the top outer wall of the storage box is fixedly connected with the fixing block, and the inner wall of the fixing block is slidably connected with a clamping plate;

[0010] The limiting mechanism includes a moving block, which is elastically connected to the inner wall of the cover plate through a telescopic spring, and the top outer wall of the shell is fixedly connected with a connecting block A and a connecting block B;

[0011] The adjusting component comprises a rotating shaft, an inner wall of the rotating shaft is elastically connected with an insert rod via a connecting spring, and an outer wall of the insert rod is fixedly connected with a clamping block.

[0012] Preferably, the rotating block is rotatably connected to the inner wall of the storage box, one end of the spiral spring is fixedly connected to the outer wall of the rotating block, and the other end of the spiral spring is fixedly connected to the inner wall of the storage box.

[0013] Preferably, an outer wall of the rotating block is provided with an oblique groove, an outer wall of the fixed block is provided with a guide groove, and a convex block is fixedly connected to the outer wall of the clamping plate, and the convex block contacts the inner walls of the guide groove and the oblique groove.

[0014] Preferably, the rotating shaft is rotatably connected to the inner wall of the storage box, one end of the connecting spring is fixedly connected to the outer wall of the insertion rod, and the other end of the connecting spring is fixedly connected to the inner wall of the rotating shaft.

[0015] Preferably, the outer wall of the insertion rod is slidably connected to the inner wall of the rotating shaft, and the clamping block passes through the outer wall of the rotating shaft.

[0016] Preferably, a slot is provided on the top outer wall of the storage box, and the rotating block and the rotating shaft are connected by a traction rope.

[0017] Preferably, one end of the telescopic spring is fixedly connected to the outer wall of the moving block, the other end of the telescopic spring is fixedly connected to the inner wall of the cover plate, and the outer wall of the moving block is slidably connected to the inner wall of the cover plate.

[0018] Preferably, the inner wall of the connection block A is elastically connected to a rotating rod via a torsion spring, the inner wall of the connection block B is fixedly connected to an insert block, and the inner wall of the connection block B is slidably connected to a sliding rod.

[0019] Preferably, one end of the torsion spring is fixedly connected to the inner wall of the connecting block A, the other end of the torsion spring is fixedly connected to the outer wall of the rotating rod, the insert block is clamped in the groove of the outer wall of the moving block, and the moving block contacts the outer wall of the sliding rod.

[0020] The present application also proposes a method for storing a constant temperature amplification reagent at room temperature, comprising the following steps:

[0021] S1. When storing the isothermal amplification reagent, the operator can first press the slide bar. After the slide bar is pressed, the moving block is squeezed to move toward the inner wall of the cover. At this time, the telescopic spring is compressed, and the groove of the moving block is out of contact with the plug-in block, releasing the limit on the cover. Due to the elastic force of the torsion spring itself, the cover flips upward and opens. After the cover is opened 90 degrees, the slide bar is released, and the telescopic spring drives the moving block to pop out. The groove of the moving block and the corresponding plug-in block are engaged again to fix the cover.

[0022] S2. Adjust the fixing mechanism according to the diameter of the reagent, pull the plug rod upward, the connecting spring is stretched, the card block is disengaged from the card slot on the outer wall of the top of the storage box, the limit on the rotating shaft is released, and the rotating shaft is rotated. When the rotating shaft rotates, the traction rope is pulled to move, and the traction rope drives the rotating block to rotate. When the rotating block rotates, the oblique groove on its outer wall squeezes the protrusion on the clamping plate. Under the guidance of the guide groove, the protrusion drives the clamping plate to move to the middle or outside at the same time. When it is necessary to fix a reagent with a larger diameter, the clamping plate moves to the outside, and the volute spring releases its own elastic force to drive the rotating block to rotate in the opposite direction; when fixing a reagent with a smaller diameter, the rotating block rotates forward, the volute spring is forced to shrink, and the three groups of clamping plates move to the middle;

[0023] S3. After rotating the shaft to a suitable position, release the plug rod, and the connecting spring rebounds, so that the card block is engaged with another set of card slots, fixes the position of the shaft, and thus fixes the position of the clamping plate, completes the adjustment of the fixing mechanism, and places the constant temperature amplification reagent in the storage box at the cavity position corresponding to the fixing mechanism, so that the reagent is fixed by the clamping plate to avoid shaking and damage during transportation or collision;

[0024] S4. After placing the reagents, press the slide bar and turn the cover downward. After the cover is closed, the insert block corresponds to the groove position on the moving block to fix the position of the cover to prevent accidental opening.

[0025] Compared with the prior art, the present invention has the following beneficial effects:

[0026] The present invention provides a rotating block and a clamping plate, etc., and the rotating block can drive the clamping plate to move in the inner wall of the guide groove. When the constant temperature amplification reagent is placed in the cavity of the storage box, the clamping plate can clamp and fix the reagent, thereby avoiding the problem of damage caused by shaking during transportation or collision.

[0027] The present invention cooperates with structures such as a rotating shaft and a traction rope, and by rotating the rotating shaft, the traction rope can be pulled and multiple groups of rotating blocks can be driven to rotate simultaneously, so that multiple groups of reagents can be fixed at the same time, thereby avoiding the need to clamp and fix the reagents one by one, which is more convenient and quick;

[0028] The present invention arranges the cooperation of structures such as the slide rod and the moving block. When the cover is closed or opened, the groove on the moving block is engaged with the plug block, so that the position of the cover can be fixed to keep it in a closed or open state, and it will not be accidentally opened to cause the reagent to fall, nor will it be easily closed when opened and require the operator to support the operation. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 It is a schematic diagram of the main structure of the present invention;

[0030] Figure 2 This is a schematic diagram of the storage box and the housing after being decomposed;

[0031] Figure 3 It is a schematic diagram of the cross-sectional structure of the storage box of the present invention;

[0032] Figure 4 It is a schematic diagram of the structure of the storage box and the rotating block after cross-section decomposition of the present invention;

[0033] Figure 5 It is a schematic diagram of the structure of the fixed block and the rotating block after cross-section decomposition of the present invention;

[0034] Figure 6 It is a cross-section of the rotating shaft and a schematic diagram of the structure after the storage box is disassembled;

[0035] Figure 7 This is a schematic diagram of the traction rope, rotating block and rotating shaft structure of the present invention;

[0036] Figure 8 It is a schematic diagram of the structure of the cover plate, the connecting block A and the connecting block B after cross-section decomposition of the present invention.

[0037] In the figure: 1. shell; 2. storage box; 3. fixing mechanism; 301. rotating block; 302. scroll spring; 303. inclined groove; 304. fixing block; 305. guide groove; 306. clamping plate; 307. protrusion; 4. adjustment component; 401. rotating shaft; 402. connecting spring; 403. plug-in rod; 404. clamping block; 405. clamping groove; 406. traction rope; 5. limiting mechanism; 501. moving block; 502. telescopic spring; 503. sliding rod; 504. plug-in block; 505. connecting block A; 506. torsion spring; 507. rotating rod; 508. connecting block B; 6. cover plate. DETAILED DESCRIPTION

[0038] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0039] like Figures 1 to 8 As shown, the present invention provides a constant temperature amplification reagent storage device at room temperature, comprising a housing 1, and further comprising:

[0040] A cover plate 6, which is arranged on the top outer wall of the housing 1 through a limiting mechanism 5;

[0041] A storage box 2, the storage box 2 is fixedly connected to the inner wall of the housing 1;

[0042] A fixing mechanism 3, the fixing mechanism 3 is arranged in the inner wall of the storage box 2 through an adjusting component 4;

[0043] The fixing mechanism 3 includes a rotating block 301, which is elastically connected to the inner wall of the storage box 2 through a spiral spring 302, a fixing block 304 is fixedly connected to the top outer wall of the storage box 2, and a clamping plate 306 is slidably connected to the inner wall of the fixing block 304;

[0044] The limiting mechanism 5 includes a moving block 501, which is elastically connected to the inner wall of the cover plate 6 through a telescopic spring 502, and a connecting block A505 and a connecting block B508 are fixedly connected to the top outer wall of the housing 1;

[0045] The adjustment component 4 includes a rotating shaft 401 , an inner wall of the rotating shaft 401 is elastically connected to an insertion rod 403 via a connecting spring 402 , and an outer wall of the insertion rod 403 is fixedly connected to a clamping block 404 .

[0046] The above scheme is adopted: the shell 1 is the main body of the shell of the constant temperature amplification reagent room temperature storage device, the constant temperature amplification reagent can be placed in the storage box 2 inside it, and the fixing mechanism 3 in the storage box 2 is provided with multiple groups, and each group of fixing mechanisms 3 has a cavity at the corresponding position. The reagent can be placed in the cavity for storage, and the reagent can be fixed by the fixing mechanism 3 to avoid damage due to shaking during transportation or collision; the position of the clamping plate 306 in the fixing mechanism 3 can be adjusted by the adjustment component 4, so that reagents of different diameters can be clamped and fixed, which is more flexible and convenient to operate; the limiting mechanism 5 can fix the position of the cover plate 6 to keep it in an open or closed state.

[0047] like Figure 3-Figure 5 As shown, the rotating block 301 is rotatably connected to the inner wall of the storage box 2, one end of the spiral spring 302 is fixedly connected to the outer wall of the rotating block 301, and the other end of the spiral spring 302 is fixedly connected to the inner wall of the storage box 2; the outer wall of the rotating block 301 is provided with an inclined groove 303, the outer wall of the fixed block 304 is provided with a guide groove 305, the outer wall of the clamping plate 306 is fixedly connected with a protrusion 307, and the protrusion 307 contacts the inner walls of the guide groove 305 and the inclined groove 303.

[0048] The above scheme is adopted: the rotating block 301 is sleeved on the outside of the fixed block 304, and when the rotating block 301 rotates, the fixed block 304 remains in a fixed state; the inner wall of each group of fixed blocks 304 is provided with three groups of clamping plates 306, and the outer wall of each group of fixed blocks 304 is provided with three groups of guide grooves 305, and the outer wall of each group of rotating blocks 301 is provided with three groups of inclined grooves 303, and the protrusions 307 on the three groups of clamping plates 306 and a group of guide grooves 305 are in contact with the inclined grooves 303; when the rotating block 301 rotates, the inclined grooves 303 will squeeze the protrusions 307 to move it, and the protrusions 307 will be guided by the guide grooves 305 and will move to the middle or outside at the same time to adapt to reagents of different diameters; when the rotating block 301 rotates, it will drive the spiral spring 302 and its fixed end to move, and compress or stretch the spiral spring 302.

[0049] like Figure 6-Figure 7 As shown, the outer wall of the insertion rod 403 is slidably connected to the inner wall of the rotating shaft 401, and the clamping block 404 penetrates the outer wall of the rotating shaft 401; a clamping groove 405 is opened on the top outer wall of the storage box 2, and the rotating block 301 and the rotating shaft 401 are connected by a traction rope 406.

[0050] The above scheme is adopted: the rotating shaft 401 is connected to each set of rotating blocks 301 by a set of traction ropes 406, and each set of traction ropes 406 is staggered up and down to avoid entanglement; when the rotating shaft 401 rotates, the traction ropes 406 will be pulled to move, and the other end of the traction ropes 406 will pull the rotating block 301 to rotate, which can drive the three sets of clamping plates 306 in the fixing mechanism 3 to move; when the rotating shaft 401 rotates to make the rotating block 301 rotate, when the three sets of clamping plates 306 move toward the middle, the volute spring 302 will be forced to shrink, and the three sets of clamping plates 306 need to fix the reagent with a larger diameter, and when they need to move to the outside, the volute spring 30 The self-elastic force can drive the rotating block 301 to rotate in the opposite direction, so that the three groups of clamping plates 306 move outward; when the insertion rod 403 is not affected by external force, the elastic force of the connecting spring 402 is in a certain position, and at this time, the clamping block 404 and a group of clamping grooves 405 are kept in a clamping state, so that the position of the rotating shaft 401 is fixed, and then the position of the clamping plate 306 is fixed; when the rotating shaft 401 needs to be rotated, the insertion rod 403 can be pulled upward to make the clamping block 404 disengage from the clamping groove 405, so that the limit of the rotating shaft 401 can be released and it can be rotated. When it is rotated to a suitable position, the clamping block 404 is clamped with another group of clamping grooves 405 to complete the adjustment operation.

[0051] like Figure 8As shown, one end of the telescopic spring 502 is fixedly connected to the outer wall of the moving block 501, the other end of the telescopic spring 502 is fixedly connected to the inner wall of the cover plate 6, and the outer wall of the moving block 501 is slidably connected to the inner wall of the cover plate 6; the inner wall of the connecting block A505 is elastically connected to the rotating rod 507 through the torsion spring 506, the inner wall of the connecting block B508 is fixedly connected to the plug block 504, and the inner wall of the connecting block B508 is slidably connected to the sliding rod 503, one end of the torsion spring 506 is fixedly connected to the inner wall of the connecting block A505, the other end of the torsion spring 506 is fixedly connected to the outer wall of the rotating rod 507, the plug block 504 is clamped in the groove of the outer wall of the moving block 501, and the moving block 501 contacts the outer wall of the sliding rod 503.

[0052] The above scheme is adopted: the rotating rod 507 is fixedly connected to the outer wall of the cover plate 6, and the cover plate 6 is rotatably connected with the connecting block A505 and the connecting block B508. When the cover plate 6 is closed, the torsion spring 506 is in a contracted state, and the position of the cover plate 6 can be fixed by engaging with the groove on the moving block 501 through the plug block 504; when the moving block 501 is out of contact with the plug block 504, the torsion spring 506 can flip the cover plate 6 upward due to its own elastic force; when the cover plate 6 is in the open or closed state, the telescopic spring 502 can keep a part of the moving block 501 outside the cover plate 6 due to its own elastic force, such as Figure 8 As shown, in this state, the groove of the moving block 501 is engaged with the corresponding plug-in block 504, so that the cover 6 remains fixed. At this time, the moving block 501 will squeeze the sliding rod 503; when the sliding rod 503 is pressed, the moving block 501 will be squeezed to move into the inner wall of the cover 6, compressing the telescopic spring 502, so that the groove of the moving block 501 is out of contact with the plug-in block 504, and the limit of the cover 6 can be released to open or close it, thereby ensuring the stability of the cover 6 when it is closed, and there is no need to support the cover 6 when it is opened to keep it in an open state, which is convenient for operators to take or place reagents.

[0053] The present application also proposes a method for storing a constant temperature amplification reagent at room temperature, comprising the following steps:

[0054] S1. When storing the isothermal amplification reagent, the operator can first press the slide bar 503. After the slide bar 503 is compressed, the movable block 501 is squeezed to move toward the inner wall of the cover plate 6. At this time, the telescopic spring 502 is compressed, and the groove of the movable block 501 is out of contact with the plug block 504, releasing the limit of the cover plate 6. Due to the elastic force of the torsion spring 506 itself, the cover plate 6 flips upward and opens. After the cover plate 6 is opened by 90 degrees, the slide bar 503 is released, and the telescopic spring 502 drives the movable block 501 to pop out, and the groove of the movable block 501 is engaged with the corresponding plug block 504 again to fix the cover plate 6;

[0055] S2, according to the diameter of the reagent, the fixing mechanism 3 is adjusted, the insertion rod 403 is pulled upward, the connecting spring 402 is stretched, the block 404 is disengaged from the slot 405 on the outer wall of the top of the storage box 2, the limit of the rotating shaft 401 is released, and the rotating shaft 401 is rotated. When the rotating shaft 401 rotates, the traction rope 406 is pulled to move, and the traction rope 406 drives the rotating block 301 to rotate. When the rotating block 301 rotates, the inclined groove 303 on its outer wall squeezes the protrusion 307 on the clamping plate 306. Under the guidance of the guide groove 305, the protrusion 307 drives the clamping plate 306 to move toward the middle or the outside at the same time. When it is necessary to fix a reagent with a larger diameter, the clamping plate 306 moves outward, and the spiral spring 302 releases its own elastic force to drive the rotating block 301 to rotate in the opposite direction; when fixing a reagent with a smaller diameter, the rotating block 301 rotates forward, the spiral spring 302 is forced to shrink, and the three groups of clamping plates 306 move toward the middle;

[0056] S3, after rotating the shaft 401 to a suitable position, loosen the rod 403, the connecting spring 402 rebounds, and the clamping block 404 is clamped with another set of clamping grooves 405, fixing the position of the shaft 401, thereby fixing the position of the clamping plate 306, completing the adjustment of the fixing mechanism 3, placing the isothermal amplification reagent in the storage box 2 at the cavity position corresponding to the fixing mechanism 3, so that the reagent is fixed by the clamping plate 306 to avoid shaking and damage during transportation or collision;

[0057] S4. After placing the reagents, press the slide bar 503 and turn the cover 6 downward. After the cover 6 is closed, the insert block 504 corresponds to the position of the groove on the moving block 501, fixing the position of the cover 6 to prevent accidental opening.

[0058] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0059] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A constant temperature amplification reagent storage device at room temperature, comprising a housing (1), characterized in that: Also includes: A cover plate (6), wherein the cover plate (6) is arranged on the top outer wall of the housing (1) via a limiting mechanism (5); A storage box (2), wherein the storage box (2) is fixedly connected to the inner wall of the housing (1); A fixing mechanism (3), wherein the fixing mechanism (3) is arranged in the inner wall of the storage box (2) via an adjustment component (4); The fixing mechanism (3) comprises a rotating block (301), the rotating block (301) being elastically connected to the inner wall of the storage box (2) via a spiral spring (302), the top outer wall of the storage box (2) being fixedly connected to a fixing block (304), and the inner wall of the fixing block (304) being slidably connected to a clamping plate (306); The limiting mechanism (5) comprises a moving block (501), the moving block (501) being elastically connected to the inner wall of the cover plate (6) via a telescopic spring (502), and the top outer wall of the shell (1) is fixedly connected with a connecting block A (505) and a connecting block B (508); The adjustment assembly (4) comprises a rotating shaft (401), the inner wall of the rotating shaft (401) is elastically connected to an insertion rod (403) via a connecting spring (402), and the outer wall of the insertion rod (403) is fixedly connected to a clamping block (404).

2. The isothermal amplification reagent room temperature storage device according to claim 1, characterized in that: The rotating block (301) is rotatably connected to the inner wall of the storage box (2), one end of the spiral spring (302) is fixedly connected to the outer wall of the rotating block (301), and the other end of the spiral spring (302) is fixedly connected to the inner wall of the storage box (2).

3. The isothermal amplification reagent room temperature storage device according to claim 1, characterized in that: The outer wall of the rotating block (301) is provided with an inclined groove (303), the outer wall of the fixed block (304) is provided with a guide groove (305), and the outer wall of the clamping plate (306) is fixedly connected with a protrusion (307), and the protrusion (307) contacts the inner walls of the guide groove (305) and the inclined groove (303).

4. The isothermal amplification reagent room temperature storage device according to claim 1, characterized in that: The rotating shaft (401) is rotatably connected to the inner wall of the storage box (2), one end of the connecting spring (402) is fixedly connected to the outer wall of the insertion rod (403), and the other end of the connecting spring (402) is fixedly connected to the inner wall of the rotating shaft (401).

5. The isothermal amplification reagent room temperature storage device according to claim 1, characterized in that: The outer wall of the insertion rod (403) is slidably connected to the inner wall of the rotating shaft (401), and the clamping block (404) passes through the outer wall of the rotating shaft (401).

6. The isothermal amplification reagent room temperature storage device according to claim 1, characterized in that: A slot (405) is provided on the top outer wall of the storage box (2), and the rotating block (301) and the rotating shaft (401) are connected via a traction rope (406).

7. The isothermal amplification reagent room temperature storage device according to claim 1, characterized in that: One end of the telescopic spring (502) is fixedly connected to the outer wall of the moving block (501), the other end of the telescopic spring (502) is fixedly connected to the inner wall of the cover plate (6), and the outer wall of the moving block (501) is slidably connected to the inner wall of the cover plate (6).

8. The constant temperature amplification reagent room temperature storage device according to claim 1, characterized in that: The inner wall of the connection block A (505) is elastically connected to a rotating rod (507) via a torsion spring (506), the inner wall of the connection block B (508) is fixedly connected to an insert block (504), and the inner wall of the connection block B (508) is slidably connected to a sliding rod (503).

9. The isothermal amplification reagent room temperature storage device according to claim 8, characterized in that: One end of the torsion spring (506) is fixedly connected to the inner wall of the connecting block A (505), and the other end of the torsion spring (506) is fixedly connected to the outer wall of the rotating rod (507). The insert block (504) is engaged with the groove on the outer wall of the moving block (501), and the moving block (501) is in contact with the outer wall of the sliding rod (503).

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