A detection pen and detection method for quickly detecting bisphenol A in thermal paper
By developing a bisphenol A detection pen and using writing color changes to detect bisphenol A, the complex, expensive and professional detection problems in the existing technology have been solved, and a rapid, economical and popularized detection effect has been achieved.
Patent Information
- Application Number
- CN202510020285.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-07
- Publication Date
- 2025-04-08
AI Technical Summary
The prior art methods for detecting bisphenol A in thermally sensitive paper require expensive instruments, the process is complex, time is long and professional skills, making it difficult to achieve rapid, economical and popularized detection.
A bisphenol A detection pen was developed to detect the presence of bisphenol A by writing on paper and observing color changes. The preparation of the detection pen consists of placing bromophenol blue and bromophenol green solutions, adding gold and silver nanoparticles, and mixing them into the marker pen.
A method of detecting bisphenol A in thermally sensitive paper is achieved quickly, conveniently and economically, and can effectively detect bisphenol A of more than 100mg/kg, solving the complex, expensive and specialized detection in the prior art.
Smart Images
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Abstract
Description
Technical Field
[0001] The invention relates to the technical field of bisphenol A detection, and in particular to a detection pen and a detection method for quickly detecting bisphenol A in thermal paper. Background Art
[0002] At present, most of the detection of bisphenol A in thermal paper on the market uses instrument detection, such as the Danish Environmental Protection Agency uses gas chromatography-mass spectrometry (GC / MS) to analyze the collected samples; the US environmental protection organization Environmental Working Group uses high-performance liquid chromatography and coulometric electrochemical detector (HPLC-CoulArray); ANSES uses liquid chromatography-tandem mass spectrometry (LC-MS / MS) technology; my country's "Liquid chromatography method for the determination of 2,2-bis(4-hydroxyphenyl)propane (bisphenol A) in paper, paperboard and pulp" (GB / T34455-2017) uses high-performance liquid chromatography coupled with fluorescence detector (HPLC-FLD) to determine bisphenol A in paper. Most of these methods require expensive instruments, the process is extremely complicated, time-consuming, expensive, and requires strong professional skills. Summary of the invention
[0003] In view of the above technical problems, the purpose of the present invention is to provide a detection pen and a detection method for quickly detecting bisphenol A in thermal paper.
[0004] The invention discloses a rapid detection pen for bisphenol A, and the preparation of the bisphenol A detection pen comprises the following steps: (1) Preparation of bromophenol blue solution: Grind bromophenol blue, NaOH solution and gold nanoparticle solution evenly, and add water to obtain a bromophenol blue solution with a mass fraction of 0.08-0.12%; the concentration of the NaOH solution is 0.05 mol / L.
[0005] Preparation method of gold nanoparticle solution: take a 0.01% chloroauric acid solution in a round-bottom flask, put in a magnetic bar for stirring, install a spherical condenser, and heat to boiling; while stirring at high speed, quickly add a 1% sodium citrate solution, reflux under vigorous stirring for 8 to 12 minutes, remove the heat source, continue stirring for 12 to 16 minutes, and cool to room temperature to obtain a gold nanoparticle solution; the volume ratio of the chloroauric acid solution to the sodium citrate solution is 10:1.
[0006] (2) Preparation of bromocresol green solution: Grind bromocresol green, NaOH solution and silver nanoparticle solution evenly, add water to obtain a bromocresol green solution with a mass fraction of 0.08-0.12%; the concentration of the NaOH solution is 0.05 mol / L.
[0007] Preparation method of silver nanoparticle solution: take a 0.01% KBH4 solution in a round-bottom flask, put in a magnetic bar for stirring, install a spherical condenser, and put in an ice bath; while stirring at high speed, quickly add a 1% AgNO3 solution, stir vigorously for 8 to 12 minutes, remove the ice bath, continue stirring for 12 to 16 minutes, cool to room temperature, and obtain a silver nanoparticle solution; the volume ratio of KBH4 solution to AgNO3 solution is 10:1.
[0008] (3) Mix equal volumes of bromophenol blue solution and bromocresol green solution to obtain a mixed solution; (4) Take 4 to 6 parts of the mixed solution, 1 to 2 parts of the preservative, 1 to 2 parts of the thickener, and 18 to 22 parts of the solvent, by weight, and stir evenly to obtain a bisphenol A detection reagent.
[0009] The preservative is one of sodium benzoate, potassium benzoate, sodium sorbate, and potassium sorbate solutions with a concentration of 0.1~0.5%; the thickener is one of polyvinyl alcohol 1788, polyvinyl alcohol 1799, or polyvinyl alcohol 0588 with a concentration of 5~10%; the solvent is one of 2-pentanol, 2-butanol, 2-ethyl pentanoate, 2-methyl pentanoate, 2-pentanone, 2-heptanone, or a mixture of the above alcohols, esters, and ketones in a molar ratio of 1:1:1.
[0010] (5) Add bisphenol A detection reagent into the empty tube of a marker pen to obtain a bisphenol A detection pen.
[0011] The invention discloses a method for quickly detecting bisphenol A in paper using a bisphenol A detection pen: writing on paper using a bisphenol A detection pen, if the light yellow handwriting written remains light yellow for a long time, it means that the paper does not contain bisphenol A or the bisphenol A content is less than 100 mg / kg; if the light yellow handwriting quickly turns into dark blue, the paper contains bisphenol A.
[0012] Beneficial effects of the present invention: The present invention uses a detection pen to write on thermal paper, and detects bisphenol A by the color change before and after writing, which is convenient, fast, economical, widely available, and low-cost. It solves the problem that the existing detection of bisphenol A in paper requires expensive instruments, an extremely complex process, a long time, high costs, and requires strong professional skills. BRIEF DESCRIPTION OF THE DRAWINGS
[0013] Figure 1 To test the writing effect of the pen on the paper without bisphenol A; Figure 2 To test the writing effect of the test pen on paper containing bisphenol A. DETAILED DESCRIPTION
[0014] The following is a further description of the rapid detection of bisphenol A test pen and the detection method of the present invention through specific implementation methods. Example
[0015] 1. Preparation of indicator 1.1 Prepare 0.05 mol / L NaOH solution Prepare 0.05 mol / L NaOH solution: Use an electronic balance to accurately weigh 2.0 g NaOH and dilute to 100 mL, shake well and set aside. 1.2 Preparation of 0.1% bromophenol blue and bromocresol green solution (1) 0.1% bromophenol blue solution: Use an electronic balance to accurately weigh 0.1 g of bromophenol blue, 3 mL of 0.05 mol / L NaOH solution, and 1 g of gold nanoparticle solution, grind them evenly, dilute with water to 100 mL, shake well and set aside.
[0016] Preparation method of gold nanoparticle solution: take 20 mL of 0.01% chloroauric acid solution into a 50 mL round-bottom flask, put in a magnetic stirrer, install a spherical condenser, and heat to boiling; while stirring at high speed, quickly add 2 mL of 1% sodium citrate solution, reflux under vigorous stirring for 10 min, remove the heat source, continue stirring for 15 min, and cool to room temperature to obtain a gold nanoparticle solution.
[0017] (2) 0.1% bromocresol green solution: grind 0.01 g bromocresol green with 21 mL 0.05 mol / L NaOH solution and 1 g silver nanoparticle solution, dilute with water to 100 mL, shake well and set aside.
[0018] Preparation method of silver nanoparticle solution: take 20 mL of 0.01% KBH4 solution into a 50 mL round-bottom flask, put in a magnetic bar for stirring, install a spherical condenser, and place in an ice bath; while stirring at high speed, quickly add 2 mL of 1% AgNO3 solution, stir vigorously for 10 min, remove the ice bath, continue stirring for 15 min, and cool to room temperature to obtain a silver nanoparticle solution.
[0019] 2. Orthogonal experiment Study the influence of different volume ratios on the test Mix 0.1% bromophenol blue solution and 0.1% bromocresol green solution in volume ratios (5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5), and test on thermal paper containing bisphenol A and thermal paper without bisphenol A. The optimal ratio of 1:1 is selected based on the response speed and color difference.
[0020] 3. Preparation of detection reagents Take 5 parts by mass of the mixed solution selected according to the orthogonal experiment (a mixed solution prepared by equal volumes of bromophenol blue solution and bromocresol green solution), 1 part of the preservative (0.3% sodium sorbate), 1 part of the thickener (8% polyvinyl alcohol 0588), 20 parts of the solvent (a mixed solution of 2-pentanol, 2-ethyl pentanoate, and 2-pentanone in a molar ratio of 1:1:1), and stir evenly to obtain a bisphenol A detection reagent. Seal and store in a brown bottle.
[0021] 4. Install the pen Use a disposable sampling tube to take an appropriate amount of the above bisphenol A detection reagent and add it to the empty tube of the marker pen to obtain a bisphenol A detection pen.
[0022] 5. Writing test The bisphenol A detection pen was tested on thermal paper containing bisphenol A, thermal paper without bisphenol A, and A4 printing paper. Through the test, we found that when writing on ordinary A4 printing paper, light yellow color marks will be left. The same results were obtained when writing on laboratory filter paper and other papers without bisphenol A. Writing on commercially available thermal paper without bisphenol A was also effectively verified, and light yellow color marks were left (such as Figure 1 When writing on thermal paper containing bisphenol A, the writing will be light yellow at first and then turn into dark blue in 2 to 3 seconds (such as Figure 2 ).
[0023] Through testing, we can find that in daily life, napkins, toilet paper, printing paper, draft paper for students, and writing exercise books do not contain bisphenol A or, more accurately, contain very small amounts of bisphenol A, which will not cause harm to the body. At the same time, the detection pen of the present invention can simply and conveniently identify whether the thermal paper contains bisphenol A. Strictly speaking, bisphenol A above 100 mg / kg can be detected. (Note: 200 mg / kg is the current EU standard for bisphenol A addition to thermal paper. my country's national standard GB / T 28210-2024 "Thermal Paper", which will be implemented on April 1, 2025, requires that the bisphenol A content shall not exceed 200 mg / kg).
Claims
1. A rapid detection pen for bisphenol A, characterized in that: The preparation of the bisphenol A detection pen comprises the following steps: (1) Preparation of bromophenol blue solution: Grind bromophenol blue, NaOH solution and gold nanoparticle solution evenly, and add water to obtain a bromophenol blue solution with a mass fraction of 0.08-0.12%; (2) Preparation of bromocresol green solution: Grind bromocresol green, NaOH solution and silver nanoparticle solution evenly, and add water to obtain a bromocresol green solution with a mass fraction of 0.08-0.12%; (3) Mix equal volumes of bromophenol blue solution and bromocresol green solution to obtain a mixed solution; (4) Take 4 to 6 parts of the mixed solution, 1 to 2 parts of the preservative, 1 to 2 parts of the thickener, and 18 to 22 parts of the solvent, by weight, and stir evenly to obtain a bisphenol A detection reagent; (5) Add bisphenol A detection reagent into the empty tube of a marker pen to obtain a bisphenol A detection pen.
2. The rapid detection bisphenol A detection pen according to claim 1, characterized in that: In steps (1) and (2), the concentration of the NaOH solution is 0.05 mol / L.
3. The rapid detection bisphenol A detection pen according to claim 1, characterized in that: In step (1), the preparation method of the gold nanoparticle solution is as follows: a 0.01% chloroauric acid solution is placed in a round-bottom flask, a magnetic rod is placed therein for stirring, a spherical condenser is installed, and the solution is heated to boiling; while stirring at high speed, a 1% sodium citrate solution is quickly added thereto, and the solution is refluxed under vigorous stirring for 8 to 12 minutes, the heat source is removed, stirring is continued for 12 to 16 minutes, and the solution is cooled to room temperature to obtain a gold nanoparticle solution; the volume ratio of the chloroauric acid solution to the sodium citrate solution is 10:
1.
4. The rapid detection bisphenol A detection pen according to claim 1, characterized in that: In step (2), the preparation method of the silver nanoparticle solution is as follows: a 0.01% KBH4 solution is placed in a round-bottom flask, a magnetic bar is placed therein for stirring, a spherical condenser is installed, and an ice bath is placed therein; while stirring at high speed, a 1% AgNO3 solution is quickly added thereto, and the mixture is stirred vigorously for 8 to 12 minutes, the ice bath is removed, stirring is continued for 12 to 16 minutes, and the mixture is cooled to room temperature to obtain a silver nanoparticle solution; the volume ratio of the KBH4 solution to the AgNO3 solution is 10:
1.
5. The rapid detection bisphenol A test pen according to claim 1, characterized in that: In step (3), the preservative is one of sodium benzoate, potassium benzoate, sodium sorbate, and potassium sorbate solutions with a concentration of 0.1-0.5%; the thickener is one of polyvinyl alcohol 1788, polyvinyl alcohol 1799, or polyvinyl alcohol 0588 with a concentration of 5-10%; and the solvent is one of 2-pentanol, 2-butanol, ethyl 2-pentanoate, methyl 2-pentanoate, 2-pentanone, and 2-heptanone, or a mixture of the above alcohols, esters, and ketones in a molar ratio of 1:1:
1.
6. The method for quickly detecting bisphenol A in thermal paper using a bisphenol A detection pen according to claim 1, characterized in that: Use a bisphenol A detection pen to write on thermal paper. If the light yellow handwriting remains light yellow for a long time, it means that the paper does not contain bisphenol A or the bisphenol A content is less than 100 mg / kg; if the light yellow handwriting quickly turns dark blue, it is paper containing bisphenol A.