A novel blood glucose test strip with high compatibility and wide detection range and its preparation method

Abstract

The present invention belongs to the technical field of blood glucose test strips, and specifically relates to a novel blood glucose test strip with high compatibility and a wide detection range and a preparation method thereof; the blood glucose test strip prepared by the present invention can be adapted to various models of blood glucose meters, reducing the trouble and additional cost for patients when replacing equipment, while having better stability and accuracy, and being able to provide consistent test results under different environmental conditions, thereby improving the reliability of blood glucose monitoring; and the blood glucose test strip prepared by the present invention can detect a wide range of blood glucose concentrations from hypoglycemia to hyperglycemia. By being able to cover a wider blood glucose range, the blood glucose test strip prepared by the present invention provides patients with more data points, helping them to fully understand their blood glucose change trends, so that patients can better control their diet, exercise and medication, reduce the risks of hypoglycemia and hyperglycemia, and improve the management effect of diabetes.

Description

Technical Field

[0001] The invention belongs to the technical field of blood glucose test strips, and in particular relates to a novel blood glucose test strip with high compatibility and a wide detection range and a preparation method thereof. Background Art

[0002] Diabetes is a common chronic metabolic disease, and patients need to monitor their blood sugar levels regularly in order to control the disease and reduce the risk of complications. Blood glucose test strips, as a convenient self-blood glucose monitoring tool, provide diabetic patients with a simple, economical and efficient way to test their blood sugar. Before the popularization of blood glucose test strips, diabetic patients mainly relied on urine tests for blood glucose testing, which indirectly reflected blood glucose levels through urine sugar. Urine glucose tests have poor accuracy because sugar is only excreted through urine when blood glucose reaches a certain threshold (usually around 180 mg / dL or 10 mmol / L), and early changes in blood glucose cannot be captured. Therefore, urine glucose tests cannot effectively monitor the blood glucose levels of diabetic patients, nor are they suitable for meticulous blood glucose management.

[0003] Chinese patent publication number CN113588935A discloses an electrochemical barcode-free blood glucose test strip and its preparation method, which covers an enzyme membrane on a PET substrate and uses HCT test compensation to obtain more accurate test results. Its use process is complicated and is not suitable for different types of home blood glucose meters on the market. Chinese patent publication number CN111366623A discloses an electrochemical blood glucose test strip with a temperature label, a preparation process and a method of use. During use, it still suffers from insufficient accuracy, low sensitivity and limited detection range. When blood glucose is too low or too high, it cannot quickly and accurately measure blood glucose results.

[0004] In view of the above technical defects, a solution is now proposed. Summary of the Invention

[0005] The purpose of the present invention is to provide a new type of blood glucose test strip with high compatibility and wide detection range and a preparation method thereof. The test strip has high compatibility and can be applied to different blood glucose testers on the market while having a wide detection range.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: a novel blood glucose test strip with high compatibility and a wide detection range is prepared by coating a blood glucose test strip reaction solution on a water-absorbing material and then bonding it to a plastic base plate. The blood glucose test strip reaction solution is composed of the following components in percentage: 45-50% phosphate buffer, 1.5-2% glucose oxidase, 43-45% normal saline, 0.5-1% nanoplatinum, 1-1.5% catalase, 0.5-1% nicotinamide adenine dinucleotide, 1-1.5% coenzyme Q, and 1-2% ascorbic acid; the plastic base plate is composed of the following components in percentage: 15-20% polyimide film, 30-35% polybutylene terephthalate, 30-35% polytrimethylene terephthalate, and 15-20% polypropylene.

[0007] The method for preparing the blood glucose test strip reaction solution comprises the following steps:

[0008] A1: Add glucose oxidase, catalase, nicotinamide adenine dinucleotide, coenzyme Q, and phosphate buffer to a reactor. Place the reactor on a magnetic stirrer, heat in a water bath at 35-45°C and 600-800 rpm, and stir for 25-30 minutes to obtain material 1.

[0009] A2: Add nano-platinum, ascorbic acid, and normal saline to a reactor, place the reactor on a magnetic stirrer, heat in a water bath, set the temperature to 55-65°C, set the speed to 1000-1200 rpm, and stir for 45-60 min to obtain material 2;

[0010] A3: Cool material 1 and material 2 to room temperature. After cooling to room temperature, mix material 1 and material 2 and place in a magnetic stirrer at 600-800 rpm for 30 minutes. After the mixing of material 1 and material 2 is completed, adjust the pH to 5.5-5.8 with ammonia water and 9% glacial acetic acid to obtain a blood glucose test strip reaction solution.

[0011] The method for preparing the plastic base plate comprises the following steps:

[0012] B1: Place polyimide film, polybutylene terephthalate, polypropylene terephthalate, and polypropylene into a high-pressure reactor. Set the reactor temperature to 110-125°C, the reactor pressure to 2.2-2.4 atm, and the magnetic stirrer speed to 1000-1200 rpm. Stir and heat-melt for 30-45 minutes.

[0013] B2: After hot melting, transfer the mixture to a homogenizer and homogenize for 5-10 minutes. After homogenization, transfer the mixture to a mold and cold press to obtain a plastic base for the blood glucose test strip.

[0014] Furthermore, the nano-platinum is white nano-platinum powder with a particle size of 20 nm; the nicotinamide adenine dinucleotide is white nicotinamide adenine dinucleotide powder with a specification of 200 mesh; the polyimide film is a non-sticky brown polyimide film with a thickness of 0.075-0.09 mm; the specifications of the plastic base of the blood glucose test strip in step B2 are 42 mm in length, 7 mm in width, and 0.4 mm in thickness.

[0015] Furthermore, a method for preparing a novel blood glucose test strip with high compatibility and wide detection range comprises the following steps:

[0016] C1: The absorbent material was bonded to the plastic base using a medical water-based adhesive. The blood glucose test strip reaction solution was then coated on the absorbent material using a coating machine. The material was then transferred to a dryer and dried at 55°C with a wind speed of 1.5 m / s for 30 min.

[0017] C2: After drying, the electrode material is attached. Then, a 0.05mm polypropylene film is bonded to the dried absorbent material using a medical water-based adhesive. After bonding, it is transferred to a screen printer. Tin oxide is used as the screen printing material. 0.1mm tin oxide is screen-printed on the polypropylene film to produce a new type of blood glucose test strip with high compatibility and a wide detection range.

[0018] Furthermore, the water-absorbing material in step C1 is a round mesh polypropylene non-woven fabric with a gram weight of 60g / m 2 The electrode material in step C2 is a silver sheet and a carbon sheet with a length of 2.5 mm, a width of 1.2 mm, and a thickness of 0.02 mm; the coating thickness of the blood glucose test strip reaction solution in step C1 is 0.05-0.08 mm;

[0019] Furthermore, the medical water-based adhesive in step S7 is composed of the following percentage components: 20-25% polyacrylic acid, 10-15% polyvinyl alcohol, 20-25% polyurethane, 8-10% glycerol, 15-20% isocyanate, 1-2% vitamin E and the balance water;

[0020] The preparation method of the medical water-based adhesive comprises the following steps:

[0021] D1: Add polypropylene, polyvinyl alcohol, and polyurethane to pure water, adjust the reactor temperature to 80-85°C, adjust the stirrer speed to 800-1000 rpm, and stir to dissolve for 30 minutes. Then, adjust the pH to 5.8-6.4 with acetic acid and ammonia water, and continue stirring for 30 minutes to obtain a resin copolymer;

[0022] D2: Add isocyanate and glycerol to pure water, adjust the reactor temperature to 55-60°C, adjust the stirrer speed to 800-1000 rpm, and stir to dissolve for 30 minutes to obtain a cyanate glycerol mixture;

[0023] D3: Mix the resin copolymer and the cyanate glycerol mixture, set the reactor temperature to 85-90°C, then add vitamin E, adjust the stirrer speed to 1200-1500 rpm, mix and stir for 1.5-2 hours, and obtain a medical water-based adhesive after stirring.

[0024] To sum up, due to the adoption of the above-mentioned technical scheme and the beneficial effects of the present invention, the blood glucose test strips prepared by the present invention can be adapted to various models of blood glucose meters, reducing the trouble and additional costs of patients when replacing equipment, and at the same time having better stability and accuracy, and can provide consistent test results under different environmental conditions, thereby improving the reliability of blood glucose monitoring, and the blood glucose test strips prepared by the present invention can detect a wide range of blood glucose concentrations from hypoglycemia to hyperglycemia. By being able to cover a wider blood glucose range, the blood glucose test strips prepared by the present invention provide patients with more data points, helping them to fully understand their blood glucose change trends, and patients can better control their diet, exercise and medication, reduce the risks of hypoglycemia and hyperglycemia, and improve the management effect of diabetes. DETAILED DESCRIPTION

[0025] In order to make the technical means, creative features, objectives and effects achieved by the present invention easier to understand, the present invention is further described below in conjunction with specific embodiments.

[0026] Unless otherwise specified, the experimental methods in the following examples are conventional methods and were performed according to the techniques or conditions described in literature in the field or according to product specifications. The materials and reagents used in the following examples are all commercially available unless otherwise specified.

[0027] Example 1

[0028] 1. Weigh the following raw materials according to mass percentage: 100 g phosphate buffer, 3 g glucose oxidase, 86 g normal saline, 1 g nanoplatinum, 2 g catalase, 1 g nicotinamide adenine dinucleotide, 2 g coenzyme Q, and 2 g ascorbic acid;

[0029] 2: Glucose oxidase, catalase, nicotinamide adenine dinucleotide, coenzyme Q and phosphate buffer were added to the reactor, and the reactor was placed on a magnetic stirrer, heated in a water bath, the temperature was set to 35°C, the speed was set to 800 rpm, and stirred for 30 minutes to obtain material 1;

[0030] 3: Add nano-platinum, ascorbic acid and normal saline to a reactor, place the reactor on a magnetic stirrer and heat it in a water bath. Set the temperature to 65°C and the speed to 1200 rpm, and stir for 60 minutes to obtain material 2;

[0031] 4: Cool material 1 and material 2 to room temperature. After cooling to room temperature, mix material 1 and material 2 and place in a magnetic stirrer at 800 rpm for 30 minutes. After the mixing of material 1 and material 2 is completed, adjust the pH to 5.8 with ammonia water and 9% glacial acetic acid to obtain the blood glucose test strip reaction solution prepared in Example 1;

[0032] Table 1,

[0033]

[0034]

[0035] The reagents and parameters used in Example 1 are shown in Table 1.

[0036] Example 2

[0037] 1. Weigh the following raw materials according to mass percentage: 90 g phosphate buffer, 4 g glucose oxidase, 90 g normal saline, 2 g nanoplatinum, 3 g catalase, 2 g nicotinamide adenine dinucleotide, 3 g coenzyme Q, and 4 g ascorbic acid;

[0038] 2: Glucose oxidase, catalase, nicotinamide adenine dinucleotide, coenzyme Q and phosphate buffer were added to a reactor, and the reactor was placed on a magnetic stirrer, heated in a water bath, the temperature was set to 45°C, the speed was set to 600 rpm, and stirred for 25 minutes to obtain material 1;

[0039] 3: Add nano-platinum, ascorbic acid and normal saline to a reactor, place the reactor on a magnetic stirrer and heat it in a water bath. Set the temperature to 55°C and the speed to 1000 rpm, and stir for 45 minutes to obtain material 2.

[0040] 4: Cool material 1 and material 2 to room temperature. After cooling to room temperature, mix material 1 and material 2 and place in a magnetic stirrer at 600 rpm for 30 minutes. After mixing, adjust the pH to 5.5 with ammonia water and 9% glacial acetic acid to obtain the blood glucose test strip reaction solution prepared in Example 2.

[0041] Table 2

[0042]

[0043]

[0044] The reagents and parameters used in Example 2 are shown in Table 2.

[0045] Example 3

[0046] 1: Add 40g of polypropylene, 20g of polyvinyl alcohol and 40g of polyurethane into pure water, adjust the reactor temperature to 85°C, adjust the stirrer speed to 1000rpm, stir and dissolve for 30min, then adjust the pH to 5.8 with acetic acid and ammonia water, and continue stirring for 30min to obtain a resin copolymer;

[0047] 2: Add 40g of isocyanate and 20g of glycerol into pure water, adjust the reactor temperature to 60°C, adjust the stirrer speed to 1000 rpm, and stir and dissolve for 30 minutes to obtain a cyanate glycerol mixture;

[0048] 3: The resin copolymer and the cyanate glycerol mixture were mixed, the reactor temperature was set to 90°C, 4 g of vitamin E was added, the stirrer speed was adjusted to 1500 rpm, and the mixture was stirred for 2 h. After stirring, the medical water-based adhesive prepared in Example 3 was obtained.

[0049] Table 3

[0050] Drug name source model parameter polyacrylic acid Changzhou Runyang Chemical Co., Ltd. GY-303 1kg polyvinyl alcohol Langfang Feitai New Material Technology Co., Ltd. 2488-5 1kg polyurethane Anhui Yuanchen New Material Technology Co., Ltd. YC-305 1kg glycerin Nanjing Rongji Chemical Co., Ltd. RJ-BSC-01 1kg Isocyanates Shanghai Kaizhi New Material Technology Co., Ltd. 44V20L 1kg Vitamin E Xi'an Miaoguo Biotechnology Co., Ltd. MG-20230222 1kg

[0051] The reagents and parameters used in Example 3 are shown in Table 3.

[0052] Example 4

[0053] 1: Add 50g of polypropylene, 30g of polyvinyl alcohol and 50g of polyurethane into pure water, adjust the reactor temperature to 85°C, adjust the stirrer speed to 1000rpm, stir and dissolve for 30min, then adjust the pH to 6.4 with acetic acid and ammonia water, and continue stirring for 30min to obtain a resin copolymer;

[0054] 2: Add 30g of isocyanate and 16g of glycerol into pure water, adjust the reactor temperature to 60°C, adjust the stirrer speed to 1000 rpm, and stir and dissolve for 30 minutes to obtain a cyanate glycerol mixture;

[0055] 3: Mix the resin copolymer and the cyanate glycerol mixture, set the reactor temperature to 85°C, then add 2g of vitamin E, adjust the stirrer speed to 1200 rpm, mix and stir for 2 hours, and after stirring, obtain the medical water-based adhesive prepared in Example 4.

[0056] Table 4

[0057] Drug name source model parameter polyacrylic acid Changzhou Runyang Chemical Co., Ltd. GY-303 1kg polyvinyl alcohol Langfang Feitai New Material Technology Co., Ltd. 2488-5 1kg polyurethane Anhui Yuanchen New Material Technology Co., Ltd. YC-305 1kg glycerin Nanjing Rongji Chemical Co., Ltd. RJ-BSC-01 1kg Isocyanates Shanghai Kaizhi New Material Technology Co., Ltd. 44V20L 1kg Vitamin E Xi'an Miaoguo Biotechnology Co., Ltd. MG-20230222 1kg

[0058] The reagents and parameters used in Example 4 are shown in Table 4.

[0059] Example 5

[0060] 1. Weigh the following raw materials according to mass percentage: 40g polyimide film, 70g polybutylene terephthalate, 70g polypropylene terephthalate, and 40g polypropylene;

[0061] 2: Put polyimide film, polybutylene terephthalate, polypropylene terephthalate and polypropylene into a high-pressure reactor, set the reactor temperature to 125°C, the reactor pressure to 2.4 atm, and the reactor magnetic stirrer speed to 1200 rpm, stir and hot-melt for 45 minutes, transfer to a homogenizer after hot-melting, homogenize for 10 minutes, transfer to a mold after homogenization, and cold-press to obtain a plastic base for a blood glucose test strip;

[0062] 3: The round-net polypropylene non-woven fabric is bonded to the plastic base plate using the medical water-based adhesive prepared in Example 3, and then the blood glucose test strip reaction liquid prepared in Example 1 is coated on the water-absorbing material using a coating machine, with a coating thickness of 0.05 mm. The resulting mixture is then transferred to a dryer and dried at 55°C and a wind speed of 1.5 m / s for 30 min. After drying, a silver sheet and a carbon sheet are attached. Subsequently, a 0.05 mm polypropylene film is bonded to the dried water-absorbing material using the medical water-based adhesive prepared in Example 3. After bonding, the resulting mixture is transferred to a screen printer, and tin oxide is used as the screen printing material. 0.1 mm tin oxide is screen-printed on the polypropylene film to obtain a new type of blood glucose test strip with high compatibility and a wide detection range as prepared in Example 5.

[0063] Table 5

[0064]

[0065] The reagents and parameters used in Example 5 are shown in Table 5.

[0066] Example 6

[0067] 1. Weigh the following raw materials according to mass percentage: 30g polyimide film, 60g polybutylene terephthalate, 60g polypropylene terephthalate, and 30g polypropylene;

[0068] 2: Put polyimide film, polybutylene terephthalate, polypropylene terephthalate and polypropylene into a high-pressure reactor, set the reactor temperature to 110°C, the reactor pressure to 2.2 atm, and the reactor magnetic stirrer speed to 1000 rpm, stir and hot-melt for 30 minutes, transfer to a homogenizer after hot melting, homogenize for 5 minutes, transfer to a mold after homogenization, and cold press to obtain a plastic base plate for blood glucose test strips;

[0069] 3: The round-net polypropylene non-woven fabric is bonded to the plastic base plate using the medical water-based adhesive prepared in Example 4, and then the blood glucose test strip reaction liquid prepared in Example 2 is coated on the water-absorbing material using a coating machine. The coating thickness is 0.08 mm, and then the fabric is transferred to a dryer and dried at 55°C and a wind speed of 1.5 m / s for 30 min. After drying, a carbon sheet and a silver sheet are attached. Then, a 0.05 mm polypropylene film is bonded to the dried water-absorbing material using the medical water-based adhesive prepared in Example 4. After bonding, the fabric is transferred to a screen printer, and tin oxide is used as the screen printing material. 0.1 mm tin oxide is screen-printed on the polypropylene film to obtain a new type of blood glucose test strip with high compatibility and a wide detection range as prepared in Example 5.

[0070] Table 6, parameter table of reagents used in Example 6

[0071]

[0072] The reagents and parameters used in Example 6 are shown in Table 6.

[0073] Comparative Example 1

[0074] Example 1 of the Chinese patent publication number CN113588935A was selected as comparative example 1.

[0075] Comparative Example 2

[0076] Example 1 of the Chinese patent publication number CN111366623A was selected as comparative example 2.

[0077] Physical performance test:

[0078] The resistivity of the blood glucose test strips prepared in Example 5, Example 6, Comparative Example 1, and Comparative Example 2 was tested using a four-probe method. After being placed at room temperature for 6 months, the resistivity was retested using the same method. The enzyme film layer of the blood glucose test strips prepared in Example 5, Example 6, Comparative Example 1, and Comparative Example 2 was rubbed 10 times to observe whether the dried enzyme film was detached from the substrate to evaluate the adhesion of the enzyme film. The sensitivity of the blood glucose test strips was calculated using an electrochemical base station test.

[0079] Table 7, Physical properties test results

[0080] Example 5 Example 6 Comparative Example 1 Comparative Example 2 Resistivity (Ω·cm) 0.0099 0.0105 0.0178 0.0217 Resistivity after half a year (Ω·cm) 0.0108 0.0109 0.0195 0.0218 Adhesion No shedding No shedding 10% shedding 20% shedding Sensitivity (μA / mmol / L) 0.237 0.222 0.317 0.323

[0081] From the analysis of Table 7, it can be seen that the enzyme membrane layer of the blood glucose test strips prepared in Example 3 and Example 4 is not easy to fall off under the action of external force and has a low resistivity, and has good sensitivity and stability during normal use.

[0082] Response time and accuracy test:

[0083] Glucose and 0.9% NaCl solution were used to prepare blood glucose quality control solutions of different concentrations, and baking soda and normal saline were used to adjust the pH to 7.35±0.05. The commercially available Yuyue Yuezhun Type 1 710 household adjustment-free blood glucose meter was used to test the blood glucose content using Example 5, Example 6, Comparative Example 1, Comparative Example 2 and the built-in blood glucose test strips, and the response time was recorded.

[0084] Table 8, Response time test results

[0085] Response time (S) Example 5I 6.8 Example 5II 6.7 Example 6I 6.5 Example 6II 6.6 Comparative Example 1I 7.9 Comparative Example 1Ⅱ 8.1 Comparative Example 2Ⅰ 9.2 Comparative Example 2Ⅱ 9.5 Self-containedⅠ 9.4 Self-contained Ⅱ 9.7

[0086] Table 9, Accuracy test results

[0087]

[0088]

[0089] By analyzing Table 8 and Table 9, it can be seen that the blood glucose test strips prepared in Example 5 and Example 6 have faster response time and reaction accuracy than those prepared in Comparative Example 1 and Comparative Example 2.

[0090] Detection range and compatibility testing

[0091] 20 home-use code-free blood glucose meters were purchased from the market. Blood glucose quality control solutions with concentrations of 1.5 mmol / L and 200.5 mmol / L were prepared using glucose and 0.9% NaCl solution and marked as low blood glucose content and high blood glucose content, respectively. The pH was adjusted to 7.35 using baking soda and normal saline. The blood glucose levels were detected using Example 5, Example 6, Comparative Example 1, and Comparative Example 2, respectively.

[0092] Table 10, Hypoglycemic Test

[0093] Example 5 Example 6 Comparative Example 1 Comparative Example 2 Blood glucose meter 1 1.5mmol / L 1.5mmol / L 1.5mmol / L 1.6mmol / L Blood glucose meter 2 1.5mmol / L 1.6mmol / L No data 1.6mmol / L Blood glucose meter 3 1.5mmol / L 1.5mmol / L 1.5mmol / L No data Blood glucose meter 4 1.6mmol / L 1.6mmol / L 1.6mmol / L No data Blood glucose meter 5 1.5mmol / L 1.6mmol / L No data No data

[0094] Table 11, High Blood Sugar Content Test

[0095]

[0096]

[0097] By analyzing Table 10 and Table 11, it can be seen that the blood glucose test strips prepared in Example 5 and Example 6 can accurately measure blood glucose values ​​under hypoglycemia and hyperglycemia conditions and are suitable for different blood glucose meters.

[0098] The basic principles, main features, and advantages of the present invention are shown and described above. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The above embodiments and descriptions are merely illustrative of the principles of the present invention. Various changes and modifications may be made to the present invention without departing from the spirit and scope of the present invention. Such changes and modifications are intended to fall within the scope of the present invention. The scope of protection claimed in the present invention is defined by the appended claims and their equivalents.

Claims

1. A new type of blood glucose test strip with high compatibility and wide detection range, characterized in that: A new type of blood glucose test strip with high compatibility and a wide detection range is prepared by coating a blood glucose test strip reaction solution on a water-absorbing material and then bonding it to a plastic base. The blood glucose test strip reaction solution is composed of the following percentage components: 45-50% phosphate buffer, 1.5-2% glucose oxidase, 43-45% normal saline, 0.5-1% nanoplatinum, 1-1.5% catalase, 0.5-1% nicotinamide adenine dinucleotide, 1-1.5% coenzyme Q and 1-2% ascorbic acid. The medical water-based adhesive used in the bonding step is composed of the following percentage components: 20-25% polyacrylic acid, 10-15% polyvinyl alcohol, 20-25% polyurethane, 8-10% glycerin, 15-20% isocyanate, 1-2% vitamin E and water as the balance; the plastic base is composed of the following percentage components: 15-20% polyimide film, 30-35% polybutylene terephthalate, 30-35% polypropylene terephthalate and 15-20% polypropylene; The method for preparing the blood glucose test strip reaction solution comprises the following steps: A1: Add glucose oxidase, catalase, nicotinamide adenine dinucleotide, coenzyme Q, and phosphate buffer to a reactor. Place the reactor on a magnetic stirrer, heat in a water bath at 35-45°C and 600-800 rpm, and stir for 25-30 minutes to obtain material 1. A2: Add nano-platinum, ascorbic acid, and normal saline to a reactor, place the reactor on a magnetic stirrer, heat in a water bath, set the temperature to 55-65°C, set the speed to 1000-1200 rpm, and stir for 45-60 min to obtain material 2; A3: Cool material 1 and material 2 to room temperature. After cooling to room temperature, mix material 1 and material 2 and place in a magnetic stirrer at 600-800 rpm for 30 minutes. After the mixing of material 1 and material 2 is completed, adjust the pH to 5.5-5.8 with ammonia water and 9% glacial acetic acid to obtain a blood glucose test strip reaction solution. The method for preparing the plastic base plate comprises the following steps: B1: The polyimide film, polybutylene terephthalate, polypropylene terephthalate and polypropylene are put into the autoclave, the reactor temperature is set to 110-125 ℃, the reactor pressure is 2.2-2.4atm, the reactor magnetic stirrer speed is set to 1000-1200rpm, stirring hot melt 30-45min; B2: After hot melting, transfer to a homogenizer and homogenize for 5-10 minutes. After homogenization, transfer to a mold and cold press to obtain a plastic base for the blood glucose test strip.

2. A novel blood glucose test strip with high compatibility and wide detection range according to claim 1, characterized in that: The nano-platinum is white nano-platinum powder with a particle size of 20 nm.

3. A novel blood glucose test strip with high compatibility and wide detection range according to claim 1, characterized in that: The nicotinamide adenine dinucleotide is white nicotinamide adenine dinucleotide powder.

4. A novel blood glucose test strip with high compatibility and wide detection range according to claim 1, characterized in that: The polyimide film is a non-sticky brown polyimide film with a thickness of 0.075-0.09 mm.

5. A novel blood glucose test strip with high compatibility and wide detection range according to claim 1, characterized in that: The specifications of the plastic base of the blood glucose test strip described in step B2 are 42 mm in length, 7 mm in width, and 0.4 mm in thickness.

6. The method for preparing a novel blood glucose test strip with high compatibility and wide detection range according to claim 1, characterized in that: The following steps are involved: C1: The absorbent material was bonded to the plastic base using a medical water-based adhesive. The blood glucose test strip reaction solution was then coated on the absorbent material using a coating machine. The material was then transferred to a dryer and dried at 55°C with a wind speed of 1.5 m / s for 30 min. C2: After drying, the electrode material is attached. Then, a 0.05mm polypropylene film is bonded to the dried absorbent material using a medical water-based adhesive. After bonding, it is transferred to a screen printer. Tin oxide is used as the screen printing material. 0.1mm tin oxide is screen-printed on the polypropylene film to produce a new type of blood glucose test strip with high compatibility and a wide detection range.

7. The method for preparing a novel blood glucose test strip with high compatibility and wide detection range according to claim 6, characterized in that: The water-absorbing material in step C1 is a rotary mesh polypropylene non-woven fabric with a gram weight of 60g / m 2 .

8. The method for preparing a novel blood glucose test strip with high compatibility and wide detection range according to claim 6, characterized in that: The electrode materials in step C2 are silver sheets and carbon sheets with a length of 2.5 mm, a width of 1.2 mm, and a thickness of 0.02 mm.

9. The method for preparing a novel blood glucose test strip with high compatibility and wide detection range according to claim 6, characterized in that: The coating thickness of the blood glucose test strip reaction solution in step C1 is 0.05-0.08 mm.

10. The method for preparing a novel blood glucose test strip with high compatibility and wide detection range according to claim 6, characterized in that: The preparation method of the medical water-based adhesive comprises the following steps: D1: Add polypropylene, polyvinyl alcohol, and polyurethane into pure water, adjust the reactor temperature to 80-85°C, adjust the stirrer speed to 800-1000 rpm, stir and dissolve for 30 minutes, then add acetic acid and continue stirring for 30 minutes to obtain a resin copolymer; D2: Add isocyanate and glycerol to pure water, adjust the reactor temperature to 55-60°C, adjust the stirrer speed to 800-1000 rpm, and stir to dissolve for 30 minutes to obtain a cyanate glycerol mixture; D3: Mix the resin copolymer and the cyanate glycerol mixture, set the reactor temperature to 85-90°C, then add vitamin E, adjust the stirrer speed to 1200-1500 rpm, mix and stir for 1.5-2 hours, and obtain a medical water-based adhesive after stirring.

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