Detoxifying hair and scalp cleansing composition, method and use thereof

Abstract

The present disclosure provides detoxified hair and scalp cleansing composition for cleansing and repairing hair. The detoxification hair and scalp cleansing composition described herein has a pH optimized to cleanse hair and scalp. The pH of the detoxification hair and scalp cleansing composition minimizes swelling and protein loss. Detoxifying hair and scalp cleansing compositions described herein comprise peptides based on the structures of keratin and keratin-related proteins. The peptides bind to hair with high affinity and repair keratin fiber damage by forming disulfide bonds and other bonding interactions such as hydrogen bonds, ionic bonds, and Van der Waals interactions.

Description

[0001] Cross-references

[0002] This application claims the benefit of U.S. Provisional Application No. 63 / 354,516, filed on June 22, 2022, which is hereby incorporated by reference in its entirety. Background Art

[0003] Hair and scalp cleansing is a common grooming habit that is considered important for optimal cleanliness, health and maintenance of hair. Hair cleansers generally remove sebum, sweat, shed stratum corneum and environmental soils, which helps prevent the development of conditions such as folliculitis and seborrheic dermatitis. Current commercial formulations employ synthetic detergents, technically described as surfactant systems that are mixed in varying amounts and ratios to achieve the desired amount of cleansing power. The beauty industry offers consumers a myriad of options to assist in general hair cleansing, covering formulations with a wide variety of ingredients and compositions.

[0004] In addition to removing sebum, sweat, shed stratum corneum and environmental dirt, the secondary function of shampoo is to impart the desired sensory effects to the hair. Thoroughly cleaned hair (i.e., completely devoid of any sebum or product) tends to feel less smooth and look duller, and as a result is generally not considered cosmetically desirable. One strategy to address this problem is to incorporate large amounts of conditioners into the cleanser. These conditioners are deposited on the surface of the hair and generally only change the surface properties of the hair, i.e., improve the appearance and feel of the hair, but do not address any potential damage to the hair structure. Excessive deposition of these conditioners, especially when combined with inadequate cleaning, can result in conditioners accumulating in the hair and weighing the hair down or making it look duller. Commercial products generally focus on providing benefits to the hair or scalp. However, the health of the hair begins with the follicles and the treatments and products applied to the hair affect the scalp; the two are inseparable. Products targeting the overall health of the hair and scalp system will provide the greatest benefits. Therefore, there is a need for new hair cleansing compositions that cleanse both the hair and the scalp, provide desirable hair properties, without excessive deposition of conditioning agents. Summary of the invention

[0005] In one aspect, the present disclosure provides a detoxifying hair and scalp cleanser composition for cleaning and repairing hair. In some embodiments, the detoxifying hair and scalp cleanser composition comprises one or more solvents, one or more peptides, one or more hair conditioners, one or more skin conditioners, one or more detoxifying agents, one or more cleansers; and one or more cosmetically or dermatologically acceptable excipients. In some embodiments, the one or more peptides comprise a peptide sequence comprising SEQ ID NO: 75, SEQ ID NO: 400, SEQ ID NO: 401, SEQ ID NO: 402, SEQ ID NO: 409, SEQ ID NO: 412, SEQ ID NO: 432, SEQ ID NO: 1131, or a combination thereof. In some embodiments, the one or more peptides comprise a peptide sequence comprising SEQ ID NO: 400, SEQ ID NO: 401, SEQ ID NO: 409, SEQ ID NO: 412, SEQ ID NO: 432, or a combination thereof. In some embodiments, the one or more peptides comprise a peptide sequence comprising SEQ ID NO: 400, SEQ ID NO: 409, SEQ ID NO: 412, or a combination thereof. In some embodiments, the one or more peptides comprise SEQ ID NO: 400. In some embodiments, the one or more peptides comprise SEQ ID NO: 409. In some embodiments, the one or more peptides comprise SEQ ID NO: 412.

[0006] In some embodiments, the concentration (% w / w) of the one or more peptides in the detoxifying hair and scalp cleanser is between about 0.0001% to about 1%. In some embodiments, the concentration (% w / w) of the one or more peptides in the detoxifying hair and scalp cleanser is between about 0.0001% to about 0.01%. In some embodiments, the concentration (% w / w) of the one or more peptides in the detoxifying hair and scalp cleanser is between about 0.0001% to about 0.001%.

[0007] In some embodiments, the detoxifying hair and scalp cleanser composition comprises one or more hair conditioners selected from the group consisting of panthenol, salicylic acid, raspberry (Rubus ideaus / raspberry) leaf extract, safflower (Carthamus tinctorius / safflower) seed extract, hydroxypropyl glucamide, hydroxypropyl ammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination thereof. In some embodiments, the detoxifying hair and scalp cleanser composition comprises one or more hair conditioners selected from the group consisting of panthenol and salicylic acid. In some embodiments, the one or more hair conditioners comprise panthenol. In some embodiments, the one or more hair conditioners comprise salicylic acid.

[0008] In some embodiments, the detoxifying hair and scalp cleansing composition comprises one or more skin conditioners selected from the group consisting of caprylyl glycol, maltooligosaccharide glucoside, hydrogenated starch hydrolysate, Opuntia ficus-indica stem extract, saccharide isomerase, alpha-glucan oligosaccharide, Alteromonas fermentation extract, Anetholea anisata leaf extract, guar hydroxypropyl triammonium chloride, or a combination thereof. In some embodiments, the detoxifying hair and scalp cleansing composition comprises one or more skin conditioners selected from the group consisting of caprylyl glycol and guar hydroxypropyl triammonium chloride. In some embodiments, the one or more skin conditioners comprise caprylyl glycol. In some embodiments, the one or more skin conditioners comprise guar hydroxypropyl triammonium chloride.

[0009] In some embodiments, the detoxifying hair and scalp cleanser composition includes one or more detoxifying agents. In some embodiments, the one or more detoxifying agents are absorbents. In some embodiments, the absorbent is charcoal powder.

[0010] In some embodiments, the detoxifying hair and scalp cleanser composition comprises one or more cleansing agents. In some embodiments, the one or more cleansing agents are surfactants. In some embodiments, the surfactant is selected from: anionic surfactants, amphoteric surfactants, nonionic surfactants, or combinations thereof.

[0011] In some embodiments, the surfactant includes at least one anionic surfactant selected from the group consisting of sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium xylene sulfonate, C 14-16In some embodiments, the at least one anionic surfactant comprises sodium olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myristyl ether sulfate, sodium xylene sulfonate, TEA dodecylbenzene sulfonate, ethyl PEG-15 coconut amine sulfate, sodium dioctyl sulfosuccinate, or a combination thereof. In some embodiments, the at least one anionic surfactant comprises C 14-16 Sodium olefin sulfonate.

[0012] In some embodiments, the surfactant comprises at least one amphoteric surfactant selected from the group consisting of cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate, or a combination thereof. In some embodiments, the at least one anionic surfactant comprises cocamidopropyl hydroxysultaine.

[0013] In some embodiments, the detoxifying hair and scalp cleanser composition comprises one or more cosmetically or dermatologically acceptable excipients selected from the group consisting of a humectant, a chelating agent, a buffering agent, or a preservative, or a combination thereof.

[0014] In some embodiments, the humectant is selected from the group consisting of glycerol, propylene glycol, propanediol, or isoprene glycol. In some embodiments, the humectant includes glycerol.

[0015] In some embodiments, the chelating agent is selected from: sodium phytate, EDTA, sodium gluconate, trisodium dicarboxymethylalanine, tetrasodium glutamate diacetate or caprylhydroxamic acid or a combination thereof. In some embodiments, the chelating agent includes caprylhydroxamic acid, sodium phytate or a combination thereof. In some embodiments, the chelating agent includes caprylhydroxamic acid. In some embodiments, the chelating agent includes sodium phytate.

[0016] In some embodiments, the buffer is selected from: citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L-arginine, sodium hydroxide, potassium hydroxide, or a combination thereof. In some embodiments, the buffer comprises citric acid, potassium hydroxide, or a combination thereof. In some embodiments, the buffer comprises citric acid. In some embodiments, the buffer comprises potassium hydroxide.

[0017] In some embodiments, the preservative is selected from the group consisting of phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination thereof.

[0018] In some embodiments, the concentration (% w / w) of the one or more solvents in the detox hair and scalp cleanser composition is between about 50% and about 90%. In some embodiments, the concentration (% w / w) of the one or more hair conditioners in the detox hair and scalp cleanser composition is between about 0.01% and about 10%. In some embodiments, the concentration (% w / w) of the one or more skin conditioners in the detox hair and scalp cleanser composition is between about 0.01% and about 5%. In some embodiments, the concentration (% w / w) of the one or more cleansers in the detox hair and scalp cleanser composition is between about 0.1% and about 20%. In some embodiments, the concentration (% w / w) of the one or more cosmetically or dermatologically acceptable excipients in the detox hair and scalp cleanser composition is between about 0.1% and about 30%. In some embodiments, the one or more solvents include water.

[0019] In some embodiments, the pH of the detoxifying hair and scalp cleansing composition is between about 4 and about 6. In some embodiments, the pH of the detoxifying hair and scalp cleansing composition is about 4. In some embodiments, the pH of the detoxifying hair and scalp cleansing composition is about 4.5. In some embodiments, the pH of the detoxifying hair and scalp cleansing composition is about 5. In some embodiments, the pH of the detoxifying hair and scalp cleansing composition is about 5.5. In some embodiments, the pH of the detoxifying hair and scalp cleansing composition is about 6.

[0020] In another aspect, a method of cleansing hair using the detoxifying hair and scalp cleanser composition described herein is provided.

[0021] Other aspects and advantages of the present disclosure may become apparent to those skilled in the art from the following detailed description, wherein only illustrative embodiments of the present disclosure are shown and described. As will be appreciated, the present disclosure is capable of other and different embodiments, and its several details are capable of modifications in various obvious respects, all without departing from the present disclosure. DETAILED DESCRIPTION

[0022] The fiber structure of human hair is composed of stratum corneum, cortex and medulla. The stratum corneum is composed of a thin layer of overlapping cells, like a scale system, and provides protection for the inner core (i.e., cortex) of the hair. Due to the presence of a large number of isopeptides and disulfide bonds in each lamellae of stratum corneum cells, stratum corneum cells are mechanically very stable and can resist many environmental factors, including the penetration of foreign molecules. The stratum corneum accounts for about 15% of the weight of a hair. The cortex is the middle region of the hair and accounts for about 80% of the weight of a hair. The cortex is composed of a hierarchical structure of elongated fibrous α-helical keratin, which extends along the fiber axis embedded in an amorphous protein matrix. It is the system of the cortex and its intertwined protein fibers and supporting matrix that gives hair its tensile properties (strength, elasticity). The cell membrane complex connects stratum corneum cells with other stratum corneum cells, cortex cells with other cortex cells, and stratum corneum cells with cortex cells. The medulla corresponds to the central cell bundle and is absent in some hair fibers.

[0023] Human hair contains about 65% to 95% protein. Proteins exhibit their active properties within a specific temperature and pH range and can unfold outside these limits. When treated with low pH solutions, thermal denaturation of fibrous hard α-keratin proteins (i.e., cortical proteins responsible for hair strength and elasticity) shows significantly improved stability. This is especially true for those keratins that have been subjected to oxidative damage (such as by bleaching), and this has been demonstrated by the significant increase in the enthalpy and peak temperature of thermal denaturation as quantified by DSC. Enthalpy is generally understood to reflect the amount and structural integrity of α-helical material in the hair intermediate filament (IF), while peak temperature reflects the cross-linking density of the matrix embedded with IF. Amino acid analysis, X-ray diffraction, Raman spectroscopy and tensile strength observations further support this phenomenon.

[0024] Alkaline pH creates a more favorable environment for cystine (disulfide) disruption, hydrolysis of amide bonds, and formation of lanthionine and lysalanine, all of which weaken the protein structure of hair. The duration of hair exposure to solutions of a particular pH does not significantly change thermal stability; combined with the fact that tap water pH varies widely from neutral to alkaline, this suggests that negative effects may be experienced for the duration of exposure that hair could reasonably be expected to experience under normal washing conditions.

[0025] The observed differences in thermal stability of hair proteins exposed to different pH are due to changes in the environment of the intermediate filaments, i.e., the interface between the IF and the surrounding matrix proteins. This scaffold structure at the surface of the IF is formed by side chain interactions that anchor the filament to the matrix. Strong adsorption of protons at the interface of the IF may help to shield this interface; disulfide bonds as well as electrostatic forces further stabilize this region.

[0026] During the cleansing process, hair is in a structurally fragile state, as water molecules disrupt the hydrogen bonds that stabilize the protein structure. This causes swelling of certain parts of the cuticle and makes the hair fiber susceptible to damage. Furthermore, it has been determined that the swelling behavior of the hair cuticle is highly dependent on pH: the more alkaline the environment, the greater the swelling. In addition to the effect on thermal stability, this modification of cuticle swelling by pH also has an impact on the properties and damage propensity of hair, which is directly relevant to the consumer. When the cuticle swells, the interfiber friction of the hair fiber increases, resulting in increased hair tangling and a rough, uncomfortable feel. Hair is also in a more fragile state when wet; the need for greater combing forces combined with the lower breaking stress of hair in the wet state can easily lead to cuticle flaking, protein loss, and even severe breakage during hair washing and shampooing. The minimal cuticle swelling exhibited at acidic pH can help to counteract this effect.

[0027] The proteins in hair are at their best (most structurally resilient) at a pH of around 5. This more acidic pH environment can also minimize excessive swelling of the stratum corneum, thereby reducing protein loss, preserving color, and minimizing electrostatic repulsion. This is also the ideal pH range for skin with an acidic mantle. Skin with a disturbed pH can experience barrier disturbances, inflammation, and irritation. The pH of tap water varies widely, from 6.5 to 9.53, and can contain metal ions such as divalent calcium and magnesium (hard water minerals) that can affect the texture of the hair, as well as trace levels of transition metals such as copper, iron, nickel, lead, etc. that can cause oxidative degradation of the hair fiber.

[0028] Additionally, peptides can be used to treat hair that has been damaged during the cleansing process. These peptides can interact with the hair primarily via covalent (disulfide) bonds, polar bonds, and hydrophobic interactions. However, penetration of peptides into the cortex of the hair strand, which is necessary for successful treatment, can be difficult. Molecular size and polarity play an important role in determining the ability of a molecule to enter the interior of the fiber structure. Additionally, the presence of sebum and products on the hair strands can hinder the ability of the peptides to successfully migrate to the cortex. While a properly acidic pH helps stabilize the protein structure of the hair (as detailed above), these peptides can work in a complementary and synergistic manner to add additional strengthening effects. Overall, this system can both protect and repair the hair protein structure, which can be fragile during the cleansing process.

[0029] To ensure that no residue is left on the hair fiber that could interfere with the ability of the peptides to penetrate the cortex, optimize protein structural reinforcement and enhance the benefits, a clarifying shampoo should be used before applying a repair treatment containing peptides. Mineral buildup can also interfere with the efficacy of peptides, so the formula must be strong enough to remove 1) product, 2) sebum, 3) hard water minerals and any other type of buildup from the hair. Salicylic acid can be challenging to formulate in a surfactant system, so choosing a strong acid-compatible surfactant that is both ion-tolerant and stable in hard water helps achieve the removal of the above three types of buildup. Detoxifiers such as charcoal, for example, isolate metal ions at low levels without the need to complicate formulation with viscosity-changing chelating agents. Charcoal contains many small pores that create a large surface area that can adsorb heavy metals, including iron (Fe), chromium (Cr), cadmium (Cd) and copper (Cu).

[0030] Thus, detoxifying hair and scalp cleansing compositions with optimized pH that reduce swelling and protein loss are provided herein. Formulating shampoos with a more acidic pH can help counteract this alkaline pH environment and minimize the net negative charge on hair proteins, which minimizes cuticle swelling and reduces binding sites for dissolved metal cations. While the use of protectants such as softeners, sealants, cations, and polymers on hair fibers minimizes friction and associated styling damage and provides a barrier to heat, UV, and pollution, excessive product accumulation can weigh hair down and prevent other products from performing. Hair compositions can include peptides that strengthen the protein structure within the hair cortex to restore the tensile strength of the hair fiber. These peptides can be incompatible with traditional conditioners that form films or coatings and can prevent the peptides from interacting with hair proteins, most particularly preventing the peptides from entering the cortex.

[0031] In some embodiments, the detoxifying hair and scalp cleaning compositions described herein comprise low molecular weight peptides that can penetrate into the cortex of the hair and improve the mechanical properties of the hair. In some embodiments, the detoxifying hair and scalp cleaning compositions described herein provide a durable improved texture and improved manageability for the hair when dry. After long-term use, the detoxifying hair and scalp cleaning compositions described herein provide a soft, shiny, undamaged texture and other desired features for the hair. The detoxifying hair and scalp cleaning compositions described herein do not strip any essential oils from the hair, reduce protein loss and repair potential hair damage, thereby avoiding over-reliance on conditioners that cover the hair fibers to achieve the desired properties. In addition, due to its limited ingredients, the detoxifying hair and scalp cleaning compositions described herein do not result in the accumulation of excess conditioners or other products that can eventually weigh the hair down.

[0032] In some embodiments, the detox hair and scalp cleaning compositions provided herein comprise one or more solvents, one or more peptides, one or more hair conditioners, one or more skin conditioners, one or more cleaning agents, and one or more cosmetically or dermatologically acceptable excipients. In some embodiments, one or more peptides have a peptide sequence of 6 to 15 amino acids. In some embodiments, 2 to 5 amino acids of the peptide sequence are cysteine. The composition of the peptide provides improved resistance, strength, toughness and elasticity for hair.

[0033] When striving for a “less is more” minimalist approach, choosing multifunctional ingredients is key. Salicylic acid has proven efficacy in skin care, providing amyloid and anti-comedogenic activity to promote healthy cell turnover while balancing sebum production, imparting photoprotection, and providing antimicrobial and anti-inflammatory effects. While these properties are expected to transfer to the scalp, the compound exhibits further scalp-specific benefits: when applied topically it can be used to treat conditions such as dandruff, ichthyosis, and psoriasis. 31 In addition to the acidic pH benefits discussed above, its pKa of approximately 2.8 and associated low pH make salicylic acid an ideal ingredient for application to hair fibers.

[0034] The detox hair and scalp cleaning compositions described herein maintain an optimal pH environment for the hair while cleaning the hair to minimize fiber swelling and maintain structural integrity. In addition, the hair cleaning compositions maintain an optimal pH environment while cleaning the scalp to avoid over-drying the scalp and will not damage the natural barrier function of the scalp. The detox hair and scalp cleaning compositions described herein have a pH optimized to clean the hair and scalp. In some embodiments, the pH of the detox hair and scalp cleaning compositions is optimized to promote the efficacy of certain ingredients in the composition. In some embodiments, the pH of the detox hair and scalp cleaning compositions is optimized to promote the efficacy of salicylic acid. In some embodiments, the pH of the composition is optimized to promote the chelation of certain minerals and metals. In some embodiments, the pH of the composition is optimized to minimize the swelling of the stratum corneum. In some embodiments, reducing stratum corneum swelling reduces the tangling of hair. In some embodiments, the pH of the composition is optimized to protect the structural integrity of the hair and mitigate the loss of proteins and lipids.

[0035] In some embodiments, the pH of the detoxifying hair and scalp cleansing composition is between about 1 and about 7. In some embodiments, the pH of the detoxifying hair and scalp cleansing composition is about 1, about 1.25, about 1.5, about 1.75, about 2, about 2.25, about 2.5, about 2.75, about 3, about 3.25, about 3.5, about 3.75, about 4, about 4.25, about 4.5, about 4.75, about 5, about 5.25, about 5.5, about 5.75, about 6, about 6.25, about 6.5, about 6.75, about 7, about, and any value therebetween. In some embodiments, the pH of the detoxifying hair and scalp cleansing composition is between about 1 and about 7, between about 2 and about 7, between about 3 and about 7, between about 3 and about 6, between about 4 and about 6, and any value therebetween.

[0036] definition

[0037] Unless otherwise defined, all technical terms, symbols, and other technical and scientific terms or expressions used herein are intended to have the same meaning as commonly understood by one of ordinary skill in the art to which the claimed subject matter belongs. In some cases, terms with commonly understood meanings are defined herein for clarity and / or for ease of reference, and such definitions contained herein should not necessarily be construed as indicating a substantial difference from what is generally understood in the art.

[0038] Throughout the application, various embodiments can be presented in a series of forms. It should be understood that the description of range form is only for convenience and simplicity, and should not be interpreted as a rigid limitation to the scope of the present disclosure. Therefore, it should be considered that the description of the scope specifically discloses all possible sub-ranges and the single numerical values ​​in the scope. For example, it should be considered that the description of the scope such as 1 to 6 specifically discloses sub-ranges (such as 1 to 3, 1 to 4, 1 to 5, 2 to 4, 2 to 6, 3 to 6, etc.) and the single numerals in the scope (for example, 1, 2, 3, 4, 5 and 6). Regardless of the width of the scope, this is applicable.

[0039] As used in this specification and claims, the singular forms "a", "an", and "the" include plural referents unless the context clearly dictates otherwise. For example, the term "a sample" includes a plurality of samples, including combinations thereof.

[0040] The terms "determining," "measuring," "evaluating," "assessing," "assaying," and "analyzing" are often used interchangeably herein to refer to forms of measurement. These terms include determining whether an element is present (e.g., detecting). These terms may include quantitative, qualitative, or both quantitative and qualitative determinations. Assessments may be relative or absolute. In addition to determining whether something is present, "detecting the presence of" may also include determining the amount present, depending on the context.

[0041] As used herein, the term "about" or "approximately" is intended to cover 20%, 10%, 5%, 1%, 0.5% or even 0.1% changes in a specified amount when referring to a measurable value (such as amount or concentration, etc.). For example, according to the practice of the art, "about" can mean plus or minus 10%. Alternatively, "about" can mean a range of plus or minus 20%, plus or minus 10%, plus or minus 5%, or plus or minus 1% of a given value. Alternatively, particularly with respect to biological systems or processes, the term can mean within the order of magnitude of a certain value, up to 5 times or up to 2 times. In the case where a specific value can be described in the application and claims, unless otherwise stated, the term "about" can be considered to cover the acceptable error range of the specific value. In addition, in the case where a range, sub-range or both of a value can be provided, these ranges or sub-ranges can include the endpoints of these ranges or sub-ranges.

[0042] Where values ​​are described as ranges, it is to be understood that such disclosure includes disclosure of all possible sub-ranges within such ranges as well as specific values ​​falling within such ranges, whether or not a specific value or specific sub-range is explicitly stated.

[0043] The terms "comprise," "have," and "include" are open-ended linking verbs. Any form or tense of one or more of these verbs, such as "comprises," "comprising," "has," "having," "includes," and "including," are also open-ended. For example, any method that "comprises," "has," or "includes" one or more steps is not limited to having only those one or more steps and also covers other unlisted steps.

[0044] As used herein, the term "mixture" or "mixtures" is intended to include a simple combination of substances as well as any compounds that may result from such combination.

[0045] As used herein, the term "cosmetically acceptable" refers to those compounds, materials, compositions and / or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of humans or animals without excessive toxicity, irritation, allergic response, or other problems or complications, commensurate with a reasonable benefit / risk ratio.

[0046] As used herein, the term "cosmetically or dermatologically acceptable" means that the composition or component is suitable for use in contact with human skin tissue without undue toxicity, incompatibility, instability, allergic response, or the like.

[0047] The section headings used herein are for organizational purposes only and are not to be construed as limiting the subject matter described.

[0048] Peptides

[0049] When washing with standard shampoos, keratin can be lost. In addition, the pH of the hair during washing can further lead to protein loss due to swelling of the hair cuticle. The present application describes detoxifying hair and scalp cleansing compositions comprising peptides based on the structure of keratin and keratin-related proteins. The peptides described herein bind to hair with high affinity and repair keratin fiber damage by forming disulfide bonds. These peptides have sequences containing one or more cysteine ​​amino acids that form disulfide bonds with free cysteine ​​amino acids in hair or keratin and participate in other types of bonding interactions that stabilize natural hair proteins. The formation of new peptide-protein bonds helps to restore the mechanical properties of hair fibers, including elasticity, resistance and appearance.

[0050] In some embodiments, the peptides described herein have a low molecular weight, between 6 and 15 amino acids, thereby improving the ability of these peptides to diffuse into the hair cortex to reduce protein damage and loss during repeated washing and chemical treatments and improve the physical and mechanical properties of the hair fiber.

[0051] In some embodiments, the peptides described herein include hydrophobic residues for increasing hydrophobicity and improving affinity for hair proteins. In some embodiments, the peptides described herein include polar residues for increasing hydrophilicity and improving affinity for hair proteins.

[0052] In some embodiments, each of the peptide sequences described herein, as well as all or part of the peptide sequences, are used alone or in combination. In some embodiments, the detoxifying hair and scalp cleansing composition comprises at least one or more peptide sequences. In some embodiments, the detoxifying hair and scalp cleansing composition comprises at least two or more peptide sequences. In some embodiments, the detoxifying hair and scalp cleansing composition comprises at least three or more peptide sequences. In other embodiments, the detoxifying hair and scalp cleansing composition comprises at least four or more peptide sequences.

[0053] The number of amino acids of the peptide sequence is 6 to 15. In some embodiments, the number of amino acids of the peptide sequence is 6. In some embodiments, the number of amino acids of the peptide sequence is 7. In some embodiments, the number of amino acids of the peptide sequence is 8. In some embodiments, the number of amino acids of the peptide sequence is 9. In some embodiments, the number of amino acids of the peptide sequence is 10. In some embodiments, the number of amino acids of the peptide sequence is 11. In some embodiments, the number of amino acids of the peptide sequence is 12. In some embodiments, the number of amino acids of the peptide sequence is 13. In some embodiments, the number of amino acids of the peptide sequence is 14. In some embodiments, the number of amino acids of the peptide sequence is 15.

[0054] In some embodiments, each peptide sequence comprises a sulfur-containing amino acid. In some embodiments, the peptide sequence comprises cysteine ​​amino acids, which interact with the hair and allow the formation of intermolecular crosslinks, thereby stabilizing the keratin fibers. In some embodiments, the detoxifying hair and scalp cleaning composition described herein comprises a peptide sequence with a high cysteine ​​content to enrich the properties of the hair, such as to improve elasticity and resistance, reduce presumed damage to the hair, improve and / or change hair characteristics. In some embodiments, cysteine ​​accounts for 10% to 50% of the total amino acids of the peptide sequence. In some embodiments, the peptide sequence comprises 2 cysteines. In some embodiments, the peptide sequence comprises 3 cysteines. In some embodiments, the peptide sequence comprises 4 cysteines. In some embodiments, the peptide sequence comprises 5 cysteines.

[0055] In some embodiments, the peptide comprises a peptide sequence comprising SEQ ID NO: 75, SEQ ID NO: 400, SEQ ID NO: 401, SEQ ID NO: 402, SEQ ID NO: 409, SEQ ID NO: 412, SEQ ID NO: 432, SEQ ID NO: 951, SEQ ID NO: 1131, or a combination thereof. In some embodiments, the peptide comprises a peptide sequence comprising at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of SEQ ID NO: 75, SEQ ID NO: 400, SEQ ID NO: 401, SEQ ID NO: 402, SEQ ID NO: 409, SEQ ID NO: 412, SEQ ID NO: 432, SEQ ID NO: 951, SEQ ID NO: 1131, or a combination thereof.

[0056] Table 1. Peptide sequences

[0057]

[0058]

[0059] The concentration of the peptide to be used depends on several factors, such as the condition of the hair, the source of the hair, and the hair treatment formulation. The peptides described herein can be prepared by conventional peptide synthesis methods well known in the art. In some embodiments, the concentration (% w / w) of one or more peptides in the detoxifying hair and scalp cleanser composition is between about 0.0001% to about 1.0%. In some embodiments, the concentration of the peptide in the detoxifying hair and scalp cleanser composition is about 0.0001%, about 0.0005%, about 0.0010%, about 0.0015%, about 0.0020%, about 0.0025%, about 0.0030%, about 0.0035%, about 0.0040%, about 0.0045%, about 0.0050%, about 0.0055%, about 0.0060%, about 0.0065%, about 0.0070%, about 0.0075%, about 0.0080%, about 0.0085%, about 0.0090%, about 0.0095%, about 0.01%, about 0.02% or about 0.03%. 0.05%, about 0.055%, about 0.060%, about 0.065%, about 0.070%, about 0.075%, about 0.080%, about 0.085%, about 0.090%, about 0.095%, about 0.1%, about 0.15%, about 020%, about 0.25%, about 0.30%, about 0.35%, about 0.40%, about 0.45%, about 0.50%, about 0.55%, about 0.60%, about 0.65%, about 0.70%, about 0.75%, about 0.80%, about 0.85%, about 0.90%, about 0.95%, about 1.0%, and any value therebetween. In some embodiments, the concentration of peptides in the detoxifying hair and scalp cleanser composition is between about 0.0001% to about 0.95%, between about 0.0005% to about 0.9%, between about 0.001% to about 0.85%, between about 0.005% to about 0.8%, between about 0.010% to about 0.75%, between about 0.050% to about 0.70%, between about 0.10% to about 0.65%, between about 0.15% to about 0.60%, between about 0.20% to about 0.55%, between about 0.25% to about 0.50%, between about 0.30% to about 0.45%, between about 0.35% to about 0.40%, and between about 0.40% to about 1.0%.

[0060] The detoxifying hair and scalp cleaning compositions described herein enrich and improve the properties and characteristics of hair, such as elasticity, strength, pH, structural integrity, appearance and feel, thereby repairing and / or protecting keratin fibers from damage. Due to the presence of cysteine-rich peptides in the composition, the detoxifying hair and scalp cleaning compositions described herein also increase resistance even after several rinses. The detoxifying hair and scalp cleaning compositions described herein act as effective cleaning materials, do not have the associated irritation of other compositions in the art, have a pH suitable for hair, and do not require excessive use of conditioning agents. In the context of the present disclosure, the detoxifying hair and scalp cleaning compositions can also be applied to hair as, but not limited to, aqueous solutions or conventional shampoos or conditioners.

[0061] Hair Conditioners

[0062] The detoxifying hair and scalp cleansing compositions described herein comprise one or more hair conditioners that repair and improve the properties of hair, such as elasticity, resistance, texture (ie, softness, smoothness, etc.), and appearance. In some embodiments, the detoxifying hair and scalp cleanser composition comprises one or more hair conditioners selected from the group consisting of panthenol, salicylic acid, sodium salicylate, carnosine, tetrahexyldecyl ascorbate, hyaluronic acid / sodium hyaluronate, hydrolyzed hyaluronic acid, sarcosine, PCA, arginine PCA, brassicyl valinate esylate, brassicyl isoleucinate esylate, brassica alcohol, glycolipids, glycosphingolipids, sphingosine, raspberry leaf extract, bis-ethyl (isostearylimidazoline) isostearamide, Camellia sinensis leaf extract, safflower seed extract, Glycine soja (soybean) seed extract, Elaeis guineensis (palm tree) fruit extract, Oryza sativa (rice) extract, hydrolyzed adansonia baobab (baobab) fruit extract, digitata seed extract, hydrolyzed corn starch, behenyl / stearyl aminopropylene glycol esters, C10-40 isoalkylamidopropyl ethyldimonium ethosulfate, Linum usitatissimum (flaxseed) extract, Salva hispanica seed extract, Astrocaryum mururmuru fruit extract, Moringa oleifera seed extract, cinnamamidopropyltrimonium chloride, hydroxypropyl guar hydroxypropyltrimonium chloride, Trifolium pratense (clover) flower extract, Opuntia ficus-indica stem extract, Kappaphycus alvarezii extract, Laminaria saccharina extract, guar hydroxypropyltrimonium chloride, bis-diglyceryl polyacyladipate-2, hydroxypropyl glucamide, hydroxypropyl ammonium gluconate, biosaccharide gum-4, prunus amygdalus dulcis (sweet almond) extract Amygdalus dulcic (sweet almond) seed extract, soy glycerides, Butyrospermum parkii (shea) butter unsaponifiables, hydrolyzed chestnut extract, glyceryl rosinate, methoxy peg-16 sodium maleate / styrene sulfonate copolymer, panthenyl hydroxypropyl steardimonium chloride, and any combination thereof.

[0063] In some embodiments, the concentration (% w / w) of one or more hair conditioners in the detoxifying hair and scalp cleanser composition is between about 0.01% and about 10.0%. In some embodiments, the concentration of one or more hair conditioners in the detoxifying hair and scalp cleanser is about 0.01%, about 0.05%, about 0.10%, about 0.15%, about 0.20%, about 0.25%, about 0.30%, about 0.35%, about 0.40%, about 0.45%, about 0.50%, about 0.55%, about 0.60%, about 0.65%, about 0.7%, about 0.8%, about 0.9%, about 10.10%, about 10.20%, about 10.30%, about 10.40%, about 10.50%, about 10.60%, about 10.70%, about 10.80%, about 10.90%, about 10.10%, about 10.10%, about 10.20%, about 10.20%, about 10.30%, about 10.30%, about 10.40%, about 10.50%, about 10.50%, about 10.60%, about 10.70%, about 10.80%, about 10.90%, about 10. 0.75%, about 0.80%, about 0.85%, about 0.90%, about 0.95%, about 1.0%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, about 10%, and any value therebetween. In some embodiments, the concentration of one or more hair conditioners in the detoxifying hair and scalp cleanser composition is between about 0.01% to about 10%, between about 0.05% to about 9.5%, between about 0.20% to about 9%, between about 0.30% to about 8.5%, between about 0.40% to about 8%, between about 0.50% to about 7.5%, between about 0.60% to about 7%, between about 0.70% to about 6.5%, between about 0.80% to about 6%, between about 0.90% to about 5.5%, and between about 1% to about 5%.

[0064] Skin Conditioners

[0065] The detoxifying hair and scalp cleanser compositions described herein include one or more skin conditioners that support the skin's barrier function and help retain moisture. In some embodiments, the detoxifying hair and scalp cleanser composition comprises one or more skin conditioners selected from the group consisting of niacinamide, allantoin, maltooligosaccharide glucoside, hydrogenated starch hydrolysate, opuntia ficus-indica stem extract, sodium hyaluronate crosspolymer, jojoba esters, hydrolyzed jojoba esters, oleic acid, linoleic acid, linolenic acid, lactobionic acid, ursolic acid / sodium ursolic acid, nordihydroguaiaretic acid, ceramides, oligofructose, galactoarabinan, schizophyllan, Anetholea anisate leaf extract, Tetraselmis suecica extract, sugar isomerase, Alteromonas ferment extract, Pseudoalteromonas ferment extract, Corylus avellana leaf extract, Phyllanthus emblica fruit extract, Betula alba extract, alba juice, Saccharumofficinarum / sugarcane extract, Rhodomyrtus tomentosa fruit extract, Hedychium coronarium root extract, Epilobium angustifolium flower / leaf / stem extract, Tremella fuciformis fruiting body extract, alpha-glucan oligosaccharide, and any combination thereof.

[0066] In some embodiments, the concentration (% w / w) of one or more skin conditioners in the detoxifying hair and scalp cleanser composition is between about 0.01% and about 5.0%. In some embodiments, the concentration of one or more skin conditioners in the detoxifying hair and scalp cleanser composition is about 0.01%, about 0.05%, about 0.10%, about 0.15%, about 0.20%, about 0.25%, about 0.30%, about 0.35%, about 0.40%, about 0.45%, about 0.50%, about 0.55%, about 0.60%, about 0.65%, about 0.70%, about 0.75%, about 0.80%, about 0.85%, about 0.90%, about 0.95%, about 1.0%, and any value therebetween. In some embodiments, the concentration of one or more skin conditioners in the detoxifying hair and scalp cleanser composition is between about 0.01% to about 0.95%, between about 0.05% to about 1.0%, between about 0.20% to about 0.90%, between about 0.30% to about 0.85%, between about 0.40% to about 0.80%, between about 0.50% to about 0.75%, between about 0.60% to about 0.70%, and between about 0.70% to about 1.0%.

[0067] Detoxifier

[0068] The detoxifying hair and scalp cleaning compositions described herein include one or more detoxifying agents that can remove dirt, oil, sebum, and any product accumulation from the hair. In some cases, the detoxifying agent can remove dandruff, acne, or scabs on the scalp. In some cases, the detoxifying agent stimulates hair follicles to cause hair growth. In some cases, the detoxifying agent reduces itching, greasiness, or inflammation. In some embodiments, the detoxifying agent is an absorbent. In some embodiments, the absorbent is charcoal powder.

[0069] In some embodiments, the concentration (% w / w) of one or more detoxifying agents in the detoxifying hair and scalp cleanser composition is between about 0.01% and about 1.0%. In some embodiments, the concentration of one or more detoxifying agents in the detoxifying hair and scalp cleanser composition is about 0.01%, about 0.05%, about 0.10%, about 0.15%, about 0.20%, about 0.25%, about 0.30%, about 0.35%, about 0.40%, about 0.45%, about 0.50%, about 0.55%, about 0.60%, about 0.65%, about 0.70%, about 0.75%, about 0.80%, about 0.85%, about 0.90%, about 0.95%, about 1.0%, and any value therebetween. In some embodiments, the concentration of one or more detoxifying agents in the detoxifying hair and scalp cleanser composition is between about 0.01% to about 0.95%, between about 0.05% to about 1.0%, between about 0.20% to about 0.90%, between about 0.30% to about 0.85%, between about 0.40% to about 0.80%, between about 0.50% to about 0.75%, between about 0.60% to about 0.70%, and between about 0.70% to about 1.0%.

[0070] Cleaning Agents

[0071] The detoxifying hair and scalp cleanser compositions described herein include one or more cleansing agents that help clean the hair but do not remove or replace any essential oils. In some embodiments, the detoxifying hair and scalp cleanser compositions comprise one or more cleansing agents selected from the group consisting of anionic surfactants, amphoteric surfactants, nonionic surfactants, biosurfactants, and any combination thereof.

[0072] In some embodiments, the one or more cleaning agents are anionic surfactants selected from the group consisting of sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium xylene sulfonate, sodium lauryl polyoxyethylene ether sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium 2-sulfolaurate, sodium myristyl polyoxyethylene ether sulfate, sodium xylene sulfonate, C 14-16 Sodium olefin sulfonate, C 14-16Sodium alpha olefin sulfonate, disodium lauryl sulfosuccinate, sodium methyl cocoyl taurate, sodium cocoyl isethionate, sodium lauryl isethionate, sodium cocoyl sarcosinate, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, lauroyl sarcosine, cocoyl sarcosine, myristoyl sarcosine, oleoyl sarcosine, myristoyl / stearoyl sarcosine, sodium lauroyl glutamate, sodium cocoyl glutamate, disodium cocoyl glutamate, cocoyl glutamate , lauroyl glutamate, potassium cocoyl glutamate, potassium lauroyl glutamate, potassium myristoyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, disodium stearoyl glutamate, sodium palmitoyl glutamate, sodium lauroyl lactylate, sodium muru palmitoleate, sodium lauryl glucoside hydroxypropyl sulfonate, disodium lauryl glucoside hydroxypropyl citrate, sodium hydroxypropyl sulfonate lauryl glucoside crosspolymer, dioctyl sodium sulfosuccinate, and any combination thereof.

[0073] In some embodiments, one or more cleaning agents are amphoteric surfactants selected from the group consisting of cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauryl betaine, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium dilauramideglutamine lysine, sodium cocoamphopropionate, lauroamphoacetate, and any combination thereof.

[0074] In some embodiments, the one or more cleaning agents are nonionic surfactants selected from the group consisting of decyl glucoside, lauryl glucoside, cocoyl glucoside, cocoyl methyl glucoamide, caprylyl / hexanoyl methyl glucoamide, lauroyl / myristoyl methyl glucoamide, cocamidopropylamine oxide, decylamine oxide, and combinations thereof.

[0075] In some embodiments, the one or more cleaning agents are biosurfactants selected from the group consisting of Sapindus mukorossi (soapnut) extract, saponins, lipopeptides, potassium cocoyl hydrolyzed oat protein, starmella bombicola / Brassica oil ferment, glycosides, glycolipids, rhamnolipids, phospholipids, and any combination thereof.

[0076] In some embodiments, the concentration (% w / w) of one or more cleansing agents in the detoxifying hair and scalp cleanser composition is between about 0.1% and about 20%. In some embodiments, the concentration of one or more cleansing agents in the detoxifying hair and scalp cleanser composition is about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, 0.7%, about 0.8%, about 0.9%, about 1.0%, about 1.2%, about 1.4%, about 1.6%, about 1.8%, about 2.0%, about 2.5%, about 3.0%, about 3.5%, about 4.0%, about 4.5%, about 5.0% , about 5.5%, about 6.0%, about 6.5%, about 7.0%, about 7.5%, about 8.0%, about 8.5%, about 9.0%, about 9.5%, about 10.0%, about 10.5%, about 11.0%, about 11.5%, about 12.0%, about 12.5%, about 13%, about 13.5%, about 14%, about 14.5%, about 15%, about 16%, about 17%, about 18%, about 19%, about 20%, and any value therebetween. In some embodiments, the concentration of one or more cleansing agents in the detoxifying hair and scalp cleanser composition is between about 0.1% to about 20%, between about 0.2% to about 19%, between about 0.3% to about 18%, between about 0.4% to about 17%, between about 0.5% to about 16%, between about 0.6% to about 15%, between about 0.7% to about 14.5%, between about 0.8% to about 14%, between about 0.9% to about 13.5%, between about 1.0% to about 13%, between about 1.5% to about 12.5%, between about 2.0% to about 12%, between about 2.5% to about 11.5%, between about 3.0% to about 11%, between about 3.5% to about 10.5%, and between about 4% to about 10%.

[0077] excipient

[0078] The detoxifying hair and scalp cleansing compositions described herein include one or more cosmetically or dermatologically acceptable excipients. Cosmetically or dermatologically acceptable excipients include, but are not limited to, preservatives, antioxidants, thickeners, chelating agents, cosolvents, sunscreens, vitamins, dyes, hair dyes, proteins, amino acids, organic polymers, natural extracts such as plant extracts, moisturizers, fragrances, perfumes, oils, softeners, lubricants, fats, penetrants, thickeners, viscosity modifiers, polymers, resins, hair fixatives, silicones, film formers, surfactants, detergents, emulsifiers, opacifiers, volatiles, propellants, liquid vehicles, carriers, salts, pH adjusters (buffers), neutralizers, buffers, hair conditioners, antistatic agents, anti-frizz agents, anti-dandruff agents, absorbents, and any combination thereof.

[0079] In some embodiments, the concentration (% w / w) of one or more cosmetically or dermatologically acceptable excipients in the detoxifying hair and scalp cleanser composition is between about 0.1% and about 30%. In some embodiments, the concentration of one or more cosmetically or dermatologically acceptable excipients in the detoxifying hair and scalp cleanser composition is about 0.1%, about 0.5%, about 1.0%, about 2.0%, about 3.0%, about 4.0%, about 5.0%, about 6.0%, about 7.0%, about 8.0%, about 9.0%, about 10.0%, about 11.0%, about 12.0%, about 13.0%, about 14.0%, about 15.0%, about 16.0%, about 17.0%, about 18.0%, about 19.0%, about 20.0%, about 21.0%, about 22.0%, about 23.0%, about 24.0%, about 25.0%, about 26.0%, about 27.0%, about 28.0%, about 29.0%, about 30.0%, about 31.0%, about 32.0%, about 33.0%, about 34.0%, about 35.0%, about 36.0%, about 37.0%, about 38.0%, about 39.0%, about 40.0%, about 41.0%, about 42.0%, about 43.0%, about 44.0%, about 45.0%, about 46.0%, about 47.0%, about 48.0%, about 49.0%, about 50.0%, about 51.0%, about 52.0%, about 53.0%, about 54.0%, about 55.0%, about 56.0%, about 57.0%, about 58.0%, about 59. 13.0%, about 14.0%, about 15.0%, about 16.0%, about 17.0%, about 18.0%, about 19.0%, about 20.0%, about 21.0%, about 22.0%, about 23.0%, about 24.0%, about 25.0%, about 26.0%, about 27.0%, about 28.0%, about 29.0%, about 30.0%, and any value therebetween. In some embodiments, the concentration of one or more cosmetically or dermatologically acceptable excipients in the detoxifying hair and scalp cleanser composition is between about 0.1% and about 29.0%, between about 0.5% and about 28.0%, between about 1.0% and about 27.0%, between about 2.0% and about 26.0%, between about 3.0% and about 25.0%, between about 4.0% and about 24.0%, between about 5.0% and about 23.0%, between about 6.0% and about 7.0%. % to about 22.0%, between about 7.0% to about 21.0%, between about 8.0% to about 20.0%, between about 9.0% to about 19.0%, between about 10.0% to about 18.0%, between about 11.0% to about 17.0%, between about 12.0% to about 16.0%, between about 13.0% to about 15.0%, between about 14.0% to about 14.5%, and between about 14.5% to about 30.0%.

[0080] In some embodiments, the one or more cosmetically or dermatologically acceptable excipients are emulsifiers selected from the group consisting of caprylic / capric / diglyceryl succinate, C14-16 glycol palmitate, C18-20 glycol isostearate, cocamidopropyl lauryl ether, dipentaerythritol hydroxystearate, dipentaerythritol hydroxyisostearate, dipentaerythritol hexacaprate / caprylate, palm kernel glycerides, lecithin, hydrogenated lecithin. Lipids, phosphatidylcholine, C12-16 alcohol, palmitic acid, glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan olive oil ester, cetearyl olive oil ester, glyceryl stearate citrate, sodium stearoyl lactylate, sodium stearoyl glutamate, sodium cocoyl glutamate, caprylyl / octyl glucoside, polyhydroxystearic acid, phenethyl alcohol, sodium subtilisin, Polyglyceryl-3, Polyglyceryl-3 Distearate, Polyglyceryl-3 Diisostearate, Polyglyceryl-3 Cocoate, Polyglyceryl-3 Dicitrate / Stearate, Polyglyceryl-3 Beeswax, Polyglyceryl-3 Polyricinoleate, Polyglyceryl-4 Oleate, Polyglyceryl-4 Caprate, Polyglyceryl-4 Laurate, Polyglyceryl-6 Caprylate, Polyglyceryl-6 Stearate, Polyglyceryl-6 Distearate, Polyglyceryl-6 Behenate, Polyglyceryl-6 Polyhydroxystearate Stearate, Polyglyceryl-6 Oleate, Polyglyceryl-6 Ricinoleate, Polyglyceryl-6 Polyricinoleate, Polyglyceryl-10 Laurate, Candelilla Wax / Jojoba / Rice Bran Polyglyceryl-3 Esters, Stearoyl Glutamate, Polysorbate-20, Polyglyceryl-10 Laurate, Polyglyceryl-6 Caprylate, Polyglyceryl-3 Cocoate, Polyglyceryl-4 Caprate, Polyglyceryl-6 Ricinoleate, Polyglyceryl-6 Caprylate, Sodium Subtilisin, and any combination thereof.

[0081] Additional chelating molecules can improve the stability of surfactant formulated foams during user experience and even remove some of the metals from the hair itself, which can result in hair that feels softer without the use of conditioning agents. To avoid underuse and subsequent reduction in the benefits of applied peptides, clarifying formulas must avoid the unpleasant "stripping" feeling that consumers associate with this, which can be achieved by combining peptides and salicylic acid in formulations to minimize cuticle swelling (which can lead to more noticeable flakes, tangles, breakage, etc.) and prevent protein loss during more aggressive clarifying shampooing. In some embodiments, the one or more cosmetically or dermatologically acceptable excipients are chelating agents selected from the group consisting of phytic acid, sodium phytate, caprylhydroxamic acid, trisodium dicarboxymethylalanine, gluconic acid, sodium gluconate, pentasodium pentetate, sodium carboxymethylinulin, tetrasodium glutamate diacetate, trisodium ethylenediamine succinate, sodium thiosulfate, diisopropyl oxalate, disodium EDTA, disodium EDTA-copper disodium, HEDTA, oxalic acid, potassium citrate, sodium citrate, dodium oxalate, TEA-EDTA, tetrasodium EDTA, trisodium EDTA, trisodium HEDTA, and any combination thereof.

[0082] In some embodiments, the one or more cosmetically or dermatologically acceptable excipients is a preservative selected from the group consisting of benzoic acid, butylparaben, diazolidinyl urea, DMDM ​​hydantoin, ethylparaben, imidazolidinyl urea, iodopropynyl butylcarbamate, isobutylparaben, methylparaben, methylchloroisothiazolinone, methylisothiazolinone, phenoxyethanol, propylparaben, sodium benzoate, potassium sorbate, ethylhexylglycerin, gluconolactone, and any combination thereof.

[0083] In some embodiments, the one or more cosmetically or dermatologically acceptable excipients are thickeners selected from the group consisting of lauryl lactate, hydroxypropyl starch phosphate, acrylates copolymer, ammonium acryloyldimethyl taurate, sodium acryloyldimethyl taurate / VP copolymer, sodium acrylate / sodium acryloyldimethyl taurate copolymer, sodium polyacrylate, polyacrylate crosspolymer-11, carbomer, acrylates / C10-30 alkyl acrylate crosspolymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, lithium sodium magnesium silicate, sodium magnesium fluorosilicate, ethylene glycol distearate, hydrogenated castor oil, hydrogenated castor oil hydroxystearate, hydrogenated castor oil isostearate, hydrogenated castor oil stearate, hydrogenated castor PEG-8 ester, and any combination thereof.

[0084] In some embodiments, one or more cosmetically or dermatologically acceptable excipients are antistatic agents. In some embodiments, the antistatic agent is a cationic surfactant selected from the group consisting of quaternary ammonium compounds, behentrimonium chloride, behentrimonium methylsulfate, cetrimonium chloride, cetrimonium methosulfate, benzalkonium chloride, benzethonium chloride, cinnamamidopropyl trimethylammonium chloride, cocotrimonium chloride, dicetyl dimethyl ammonium chloride, dicocodimonium chloride, lauryl trimethyl ammonium chloride, stearamidopropyl dimethylamine, steartrimonium chloride, stearalkonium chloride, tricetyl dimethyl ammonium chloride, PCA cocoyl arginine ethyl ester salt, C10-40 isoalkylamidopropyl ethyl dimethyl ammonium ethylsulfate, dipalmitoyloxyethyl hydroxyethyl methyl ammonium methylsulfate, shea butter amidopropyl trimethyl ammonium chloride, and any combination thereof.

[0085] In some embodiments, one or more cosmetically or dermatologically acceptable excipients are naturally derived polymers selected from the group consisting of xanthan gum, pullulan, algin, guar (guar) gum, sclerotium gum, gum arabic Senegal, cellulose, cellulose gum, carboxymethyl cellulose, carbomer, hydroxypropyl starch phosphate, guar hydroxypropyltrimonium chloride, carboxymethyl hydroxyethyl cellulose, carboxymethyl hydroxypropyl guar, cellulose, ethyl cellulose, hydroxybutyl methyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, lauryl polydextrose, and any combination thereof.

[0086] In some embodiments, the one or more cosmetically or dermatologically acceptable excipients is an amino acid, such as L-cysteine.

[0087] In some embodiments, the one or more cosmetically or dermatologically acceptable excipients are humectants selected from the group consisting of 1,2,6 hexanetriol, dipropylene glycol, glycerin, butylene glycol, caprylyl glycol, pentylene glycol, isopentyl glycol, hexylene glycol, panthenol, phytantriol, 1,2-propylene glycol, 1,3-propylene glycol, sodium PCA, sorbitol, triethylene glycol, polyglyceryl sorbitol, glucose, fructose, mannitol, xylitol, inositol, trehalose, polydextrose, potassium PCA, hydrogenated honey, hyaluronic acid, inositol, erythritol, capryl glycol, acetamidoethoxyethanol, and any combination thereof.

[0088] In some embodiments, the one or more cosmetically or dermatologically acceptable excipients are cationic polymers selected from the group consisting of polyquaternium-10, polyquaternium-7, polyquaternium-11, polyquaternium-57, quaternium-15, quaternium-18, quaternium-22, quaternium-87, guar hydroxypropyltrimonium chloride, and any combination thereof.

[0089] In some embodiments, one or more cosmetically or dermatologically acceptable excipients are nonionic surfactants selected from the group consisting of decyl glucoside, lauryl glucoside, cocoyl glucoside, cocoyl methyl glucoside, capryl / hexanoyl methyl glucoside, lauroyl / myristoyl methyl glucoside, cocamidopropylamine oxide, decylamine oxide, and combinations thereof. In some embodiments, the nonionic surfactant is a solubilizer, an emulsifier, a stabilizer, an emollient, a thickener, and any combination thereof.

[0090] In some embodiments, the one or more cosmetically or dermatologically acceptable excipients are silicones selected from amodimethicone, amodimethicone, dimethicone cyclomethicone, cyclopentasiloxane, dimethicone, dimethicone copolyol, dimethiconol, hydrolyzed wheat protein hydroxypropyl polysiloxane, trimethylsilyl amodimethicone, and any combination thereof.

[0091] In some embodiments, the one or more cosmetically or dermatologically acceptable excipients are proteins selected from the group consisting of cocodimonium hydroxypropyl hydrolyzed casein, cocodimonium hydroxypropyl hydrolyzed collagen, cocodimonium hydroxypropyl hydrolyzed hair keratin, cocodimonium hydroxypropyl hydrolyzed keratin, cocodimonium hydroxypropyl hydrolyzed rice protein, cocodimonium hydroxypropyl hydrolyzed silk, cocodimonium hydroxypropyl hydrolyzed soy protein, cocodimonium hydroxypropyl hydrolyzed wheat protein, cocodimonium hydroxypropyl silk amino acids, cocoyl hydrolyzed collagen, cocoyl hydrolyzed keratin, hydrolyzed keratin, hydrolyzed oat flour, hydrolyzed silk, hydrolyzed silk protein, hydrolyzed soy protein, hydrolyzed wheat protein, hydrolyzed quinoa, hydrolyzed elastin, hydrolyzed collagen, keratin, potassium cocoyl hydrolyzed collagen, and any combination thereof.

[0092] In some embodiments, the one or more cosmetically or dermatologically acceptable excipients is a vitamin selected from the group consisting of retinol, retinyl palmitate, ascorbic acid, tocopherol, tocopherol acetate, and any combination thereof.

[0093] In some embodiments, one or more cosmetically or dermatologically acceptable excipients are natural extracts selected from the group consisting of Aloe barbadensis leaf extract, Yucca schidigera leaf extract, Yucca schidigera root extract, tea leaf extract, Equisetum arvense leaf extract, Hamamelis virginiana leaf extract, Macrocystis pyrifera kelp extract, and combinations thereof.

[0094] In some embodiments, the one or more cosmetically or dermatologically acceptable excipients are emollients selected from the group consisting of isopropyl lauroyl sarcosinate, phenethyl benzoate, C12-15 alkyl benzoate, caprylic / capric triglyceride, cetyl caprylate, octyldodecanol, dilinoleic acid / 1,3-Propanediol Copolymer, Isoamyl Laurate, Oleic Acid, Isohexadecane, Squalane, Isopropyl Palmitate, Polycitronellol, Diheptyl Succinate, Caprylyl Glyceryl / Sebacic Acid Copolymer, PPG-3 Benzyl Ether Ethylhexanoate, Hydrogenated Vegetable Oil, Triheptanoin, Diisopropyl Sebacate, Diisopropyl Adipate, Propylene Glycol Dibenzoate, Propoxytetramethylpiperidinyl Dimethicone, Castor Oil / IPDI Copolymer, Butylene Glycol Cocoate, Butylene Glycol Dicaprylate / Dicaprate (Dispersant), Propylene Glycol Dicaprylate / Dicaprate, Triolein (Algae Oil), Propylene Glycol Dicaprylate / Dicaprate, Phytosterols / Octyldodecyl Lauroyl Glutamate, C10-18 Triglycerides, Isostearyl Alcohol, Diisostearyl Malate, Isoamyl Laurate, Isoamyl Cocoate, Squalane, Polycitronellol Acetate, Ethyl Macadamia Oleate, Coconut Caprylate / Caprate, Coconut Alkanes, C9-12 Alkanes, C13-15 Alkanes, C13-16 Isoalkanes, Neopentyl Glycol Diheptanoate, Ethylhexyl Hydrogenated Olive Oil, Hydrogenated Olive Oil Unsaponifiables, Undecane, Tridecane, Isododecane, Octyl Caprylate / Caprate, Cetearyl Stearate, Cetearyl Stearate, Decyl Oleate, Glyceryl Stearate, Glyceryl Hexylene Glycol Acids, Glyceryl Arachidate, Glyceryl Arachidonate, Glyceryl Behenate, Glyceryl Caprate, Glyceryl Caprylate, Glyceryl Caprylate / Caprate, Glyceryl Citrate / Lactate / Linoleate / Oleate, Glyceryl Cocoate, Glyceryl Diarachidate, Glyceryl Dibehenate, Glyceryl Dierucate, Glyceryl Dihydroxystearate, Glyceryl Diisopalmitate, Glyceryl Diisostearate, Glyceryl Dilaurate, Glyceryl Dilinoleate, Glyceryl Dimyristate, Glyceryl Dioleate, Glyceryl Dipalmitate, Glyceryl Dipalmitoleate, Glyceryl Diricinoleate, Glyceryl Distearate, Glyceryl Erucate, Glycol Stearate , isocetyl stearate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, isostearyl stearate, octyl palmitate, octyl stearate, propylene glycol dicaprylate / dicaprate, sorbitan benzoate, sorbitan caprylate, sorbitan isostearate, sorbitan laurate, sorbitan tristearate, stearyl stearate, tocopheryl linoleate, olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, sesame (sesamumindicum / sesame) seed oil, prunus areniaca (apricot) kernel oil, crambe abyssinica seed oil, rice bran oil, grape (vitis vinifera / grape) seed oil, passionflower (Passiflora edulis) seed oil, meadowfoam (meadowfoam) seed oil, shea butter, shorea robusta seed butter, star fruit palm butter, and any combination thereof.

[0095] In some embodiments, the one or more cosmetically or dermatologically acceptable excipients are antioxidants selected from the group consisting of carnosine, tetrahexyldecyl ascorbate, bioflavonoids, lycopene, carrot (daucus carotasativa) root cell culture lysate, monoammonium glycyrrhizinate, alpha lipoic acid (thioctic acid), Leontopodium alpinum (leontopodium) extract, Rosmarinus officinalis (rosemary) leaf extract (WS), grape seed extract, tea leaf extract, Quercus robur wood extract, hydrolyzed olive fruit, Olea europea (olive) leaf extract, oleuropein, pomegranate (Punica granatum) bark / fruit extract, punicalagin, ellagic acid, polyphenols, epigallocatechin-3-glucan (EGCG), tannins, sulforaphane, resveratrol, nordihydroguaiaretic acid, and any combination thereof.

[0096] In some embodiments, the one or more cosmetically or dermatologically acceptable excipients is a buffer selected from ascorbic acid, citric acid, lactic acid, glycolic acid, tartaric acid, malic acid, L-arginine, potassium hydroxide, sodium hydroxide, triethanolamine, sodium bicarbonate, and any combination thereof.

[0097] In some embodiments, the one or more cosmetically or dermatologically acceptable excipients is a salt selected from the group consisting of calcium chloride, magnesium chloride, magnesium sulfate, potassium chloride, potassium glycol sulfate, sodium chloride, and any combination thereof.

[0098] In some embodiments, the one or more cosmetically or dermatologically acceptable excipients are fatty alcohols selected from the group consisting of lauric acid, palmitic acid, stearic acid, arachidyl alcohol, behenyl alcohol, cetearyl alcohol, cetyl alcohol, isocetyl alcohol, isostearyl alcohol, lauryl alcohol, myristyl alcohol, stearyl alcohol, C30-50 alcohols, lanolin alcohol, and any combination thereof.

[0099] In some embodiments, one or more cosmetically or dermatologically acceptable excipients are fragrance ingredients. In some embodiments, the fragrance ingredients include fragrances. In some embodiments, the fragrances include limonene.

[0100] Solvent

[0101] The detoxifying hair and scalp cleanser composition includes one or more solvents. In some embodiments, the one or more solvents are selected from: water; dimethyl isosorbide; triethyl citrate; phenylethyl benzoate; dioctyl maleate; dilinoleic acid / 1,3-propylene glycol copolymer; lower alcohols containing 1 to 6 carbon atoms, such as ethanol; polyols, such as glycerol, glycols (such as butylene glycol, isoprene glycol, 1,2-propylene glycol, dipropylene glycol, 1,3-propylene glycol, isopentyldiol), polyethylene glycols (such as PEG-8), sorbitol; sugars, such as glucose, fructose, maltose, lactose, sucrose; and any combination thereof.

[0102] In some embodiments, the concentration (% w / w) of one or more solvents or co-solvents in the detoxifying hair and scalp cleansing composition is between about 50% and about 90%. In some embodiments, the concentration of one or more solvents in the detoxifying hair and scalp cleansing composition is about 50%, about 55%, about 60%, about 65%, 70%, about 75%, about 80%, about 85%, about 90%, and any value therebetween. In some embodiments, the concentration of one or more solvents in the detoxifying hair and scalp cleansing composition is between about 50% and about 90%, between about 55% and about 85%, between about 60% and about 80%, between about 65% and about 80%, and between about 70% and about 80%.

[0103] Preparations

[0104] In some embodiments, the hair cleaning composition comprises:

[0105] one or more solvents;

[0106] one or more peptides;

[0107] one or more hair conditioners;

[0108] one or more skin conditioning substances;

[0109] one or more detoxifying agents;

[0110] one or more cleaning agents; and

[0111] one or more cosmetically or dermatologically acceptable excipients;

[0112] wherein the one or more peptides comprise a peptide sequence comprising SEQ ID NO:75, SEQ ID NO:400, SEQ ID NO:401, SEQ ID NO:402, SEQ ID NO:409, SEQ ID NO:412, SEQ ID NO:432, SEQ ID NO:1131 or a combination thereof.

[0113] In some embodiments, the hair cleaning composition comprises:

[0114] between about 50% to about 90% (% w / w) of one or more solvents;

[0115] between about 0.0001% to about 1.0% (% w / w) of one or more peptides;

[0116] between about 0.01% to about 10.0% (% w / w) of one or more hair conditioners;

[0117] between about 0.01% to about 5.0% (% w / w) of one or more skin conditioners;

[0118] between about 0.01% to about 1.0% (% w / w) of one or more detoxifying agents;

[0119] Between about 0.1% to about 20% (% w / w) of one or more cleaning agents; and

[0120] between about 0.1% to about 30% (% w / w) of one or more cosmetically or dermatologically acceptable excipients;

[0121] wherein the one or more peptides comprise a peptide sequence comprising SEQ ID NO:75, SEQ ID NO:400, SEQ ID NO:401, SEQ ID NO:402, SEQ ID NO:409, SEQ ID NO:412, SEQ ID NO:432, SEQ ID NO:1131 or a combination thereof.

[0122] In some embodiments, the hair cleaning composition comprises:

[0123] between about 55% to about 85% (% w / w) of one or more solvents;

[0124] between about 0.0001% to about 0.9% (% w / w) of one or more peptides;

[0125] between about 0.20% to about 9% (% w / w) of one or more hair conditioners;

[0126] between about 0.01% to about 0.95% (% w / w) of one or more skin conditioners;

[0127] between about 0.05% to about 1.0% (% w / w) of one or more detoxifying agents;

[0128] Between about 0.3% to about 18% (% w / w) of one or more cleaning agents; and

[0129] between about 0.5% to about 28.0% (% w / w) of one or more cosmetically or dermatologically acceptable excipients;

[0130] wherein the one or more peptides comprise a peptide sequence comprising SEQ ID NO:75, SEQ ID NO:400, SEQ ID NO:401, SEQ ID NO:402, SEQ ID NO:409, SEQ ID NO:412, SEQ ID NO:432, SEQ ID NO:1131 or a combination thereof.

[0131] In some embodiments, the hair cleaning composition comprises:

[0132] between about 55% to about 85% (% w / w) of one or more solvents;

[0133] between about 0.0001% to about 0.9% (% w / w) of one or more peptides;

[0134] between about 0.20% to about 9% (% w / w) of one or more hair conditioners;

[0135] between about 0.01% to about 0.95% (% w / w) of one or more skin conditioners;

[0136] between about 0.05% to about 1.0% (% w / w) of one or more detoxifying agents including absorbents;

[0137] Between about 0.3% to about 18% (% w / w) of one or more cleaning agents selected from the group consisting of anionic surfactants, amphoteric surfactants, nonionic surfactants, biosurfactants, and any combination thereof; and

[0138] Between about 0.5% to about 28.0% (% w / w) of one or more cosmetically or dermatologically acceptable excipients selected from the group consisting of preservatives, antioxidants, thickeners, chelating agents, co-solvents, sunscreens, vitamins, dyes, hair dyes, proteins, amino acids, organic polymers, natural extracts such as plant extracts, humectants, flavors, perfumes, oils, emollients, lubricants, greases, penetrants, thickeners, viscosity modifiers, polymers, resins, hair fixatives, silicones, film formers, surfactants, detergents, emulsifiers, opacifiers, volatiles, propellants, liquid vehicles, carriers, salts, pH adjusters (buffers), neutralizers, buffers, hair conditioners, antistatic agents, anti-frizz agents, anti-dandruff agents, absorbents, and any combination thereof;

[0139] wherein the one or more peptides comprise a peptide sequence comprising SEQ ID NO:75, SEQ ID NO:400, SEQ ID NO:401, SEQ ID NO:402, SEQ ID NO:409, SEQ ID NO:412, SEQ ID NO:432, SEQ ID NO:1131 or a combination thereof.

[0140] In some embodiments, the hair cleaning composition comprises:

[0141] Between about 55% to about 85% (% w / w) of one or more solvents selected from the group consisting of: water; dimethyl isosorbide; triethyl citrate; phenylethyl benzoate; dioctyl maleate; dilinoleic acid / propylene glycol copolymer; lower alcohols containing 1 to 6 carbon atoms, such as ethanol; polyols, such as glycerol, glycols (such as butylene glycol, isoprene glycol, 1,2-propylene glycol, dipropylene glycol, 1,3-propylene glycol, isopentyl glycol), polyethylene glycols (such as PEG-8), sorbitol; sugars, such as glucose, fructose, maltose, lactose, sucrose; and any combination thereof;

[0142] between about 0.0001% to about 0.9% (% w / w) of one or more peptides;

[0143] Between about 0.20% to about 9% (% w / w) of one or more hair conditioners selected from the group consisting of panthenol, salicylic acid, sodium salicylate, carnosine, tetrahexyldecyl ascorbate, hyaluronic acid / sodium hyaluronate, hydrolyzed hyaluronic acid, sarcosine, PCA, arginine PCA, brassica valine ester ethyl sulfonate, brassica oleucinate ethyl sulfonate, brassica alcohol, glycolipids, glycosphingolipids, sphingosine, raspberry leaf extract, bis-ethyl (isostearylimidazoline) isostearamide, camellia sinensis leaf extract, safflower seed extract, soja (soybean) seed extract, elaeis (palm) fruit extract, rice extract, hydrolyzed baobab seed extract, hydrolyzed corn starch, behenyl / stearyl aminopropanediol esters, C10-40 isoalkamidopropyl ethyl dimethyl ammonium ethosulfate, linum usitatissimum (linseed) extract, salvia hispanica seed extract, aster murrum fruit extract, moringa oleifera seed extract, cinnamamidopropyltrimonium chloride, hydroxypropyl guar hydroxypropyltrimonium chloride, clover (trifolium pratense) flower extract, opuntia cochinchinensis stem extract, kappaphycus longicornis extract, laminaria saccharifolia extract, guar hydroxypropyltrimonium chloride, bis-diglyceryl polyacyladipate-2, hydroxypropyl glucamide, hydroxypropyl ammonium gluconate, biosaccharide gum-4, prunus amygdalus dulcis seed extract, soy glycerides, butyrospermum parkii (shea) butter unsaponifiables, hydrolyzed chestnut extract, glyceryl rosinate, sodium methoxy peg-16 maleate / styrene sulfonate copolymer, panthenyl hydroxypropyl steardimonium chloride, and any combination thereof;

[0144] Between about 0.01% to about 0.95% (% w / w) of one or more skin conditioning agents selected from the group consisting of niacinamide, allantoin, maltooligosaccharide glucoside, hydrogenated starch hydrolysate, opuntia ficus-indica stem extract, sodium hyaluronate crosspolymer, jojoba esters, hydrolyzed jojoba esters, oleic acid, linoleic acid, linolenic acid, lactobionic acid, ursolic acid / sodium ursolic acid, nordihydroguaiaretic acid, ceramides, oligofructose, galactoarabinan, schizophyllan, myrtle leaf extract, swedish algae extract, saccharide isomerase, altermonas ferment extract, pseudoalteromonas ferment extract, corylus avellana leaf extract, emblica emblica fruit extract, birch juice, sugar cane extract, myrtle fruit extract, ginger flower root extract, angustifolia flower / leaf / stem extract, tremella fruiting body extract, alpha-glucan oligosaccharide, and any combination thereof;

[0145] between about 0.05% to about 1.0% (% w / w) of one or more detoxifying agents including absorbents;

[0146] Between about 0.3% to about 18% (% w / w) of one or more cleaning agents selected from the group consisting of anionic surfactants, amphoteric surfactants, nonionic surfactants, biosurfactants, and any combination thereof; and

[0147] Between about 0.5% to about 28.0% (% w / w) of one or more cosmetically or dermatologically acceptable excipients selected from the group consisting of preservatives, antioxidants, thickeners, chelating agents, co-solvents, sunscreens, vitamins, dyes, hair dyes, proteins, amino acids, organic polymers, natural extracts such as plant extracts, humectants, flavors, perfumes, oils, emollients, lubricants, greases, penetrants, thickeners, viscosity modifiers, polymers, resins, hair fixatives, silicones, film formers, surfactants, detergents, emulsifiers, opacifiers, volatiles, propellants, liquid vehicles, carriers, salts, pH adjusters (buffers), neutralizers, buffers, hair conditioners, antistatic agents, anti-frizz agents, anti-dandruff agents, absorbents, and any combination thereof;

[0148] wherein the one or more peptides comprise a peptide sequence comprising SEQ ID NO:75, SEQ ID NO:400, SEQ ID NO:401, SEQ ID NO:402, SEQ ID NO:409, SEQ ID NO:412, SEQ ID NO:432, SEQ ID NO:1131 or a combination thereof.

[0149] In some embodiments, the hair cleaning composition comprises:

[0150] Between about 55% to about 85% (% w / w) of one or more solvents selected from the group consisting of: water; dimethyl isosorbide; triethyl citrate; phenylethyl benzoate; dioctyl maleate; dilinoleic acid / propylene glycol copolymer; lower alcohols containing 1 to 6 carbon atoms, such as ethanol; polyols, such as glycerol, glycols (such as butylene glycol, isoprene glycol, 1,2-propylene glycol, dipropylene glycol, 1,3-propylene glycol, isopentyl glycol), polyethylene glycols (such as PEG-8), sorbitol; sugars, such as glucose, fructose, maltose, lactose, sucrose; and any combination thereof;

[0151] between about 0.0001% to about 0.9% (% w / w) of one or more peptides;

[0152] Between about 0.20% to about 9% (% w / w) of one or more hair conditioners selected from the group consisting of panthenol, salicylic acid, sodium salicylate, carnosine, tetrahexyldecyl ascorbate, hyaluronic acid / sodium hyaluronate, hydrolyzed hyaluronic acid, sarcosine, PCA, arginine PCA, brassica valine ester ethyl sulfonate, brassica oleucinate ethyl sulfonate, brassica alcohol, glycolipids, glycosphingolipids, sphingosine, raspberry leaf extract, bis-ethyl (isostearylimidazoline) isostearamide, camellia sinensis leaf extract, safflower seed extract, soja (soybean) seed extract, elaeis (palm) fruit extract, rice extract, hydrolyzed baobab seed extract, hydrolyzed corn starch, behenyl / stearyl aminopropanediol esters, C10-40 isoalkamidopropyl ethyl dimethyl ammonium ethosulfate, linum usitatissimum (linseed) extract, salvia hispanica seed extract, aster murrum fruit extract, moringa oleifera seed extract, cinnamamidopropyltrimonium chloride, hydroxypropyl guar hydroxypropyltrimonium chloride, clover (trifolium pratense) flower extract, opuntia cochinchinensis stem extract, kappaphycus longicornis extract, laminaria saccharifolia extract, guar hydroxypropyltrimonium chloride, bis-diglyceryl polyacyladipate-2, hydroxypropyl glucamide, hydroxypropyl ammonium gluconate, biosaccharide gum-4, prunus amygdalus dulcis seed extract, soy glycerides, butyrospermum parkii (shea) butter unsaponifiables, hydrolyzed chestnut extract, glyceryl rosinate, sodium methoxy peg-16 maleate / styrene sulfonate copolymer, panthenyl hydroxypropyl steardimonium chloride, and any combination thereof;

[0153] Between about 0.01% to about 0.95% (% w / w) of one or more skin conditioning agents selected from the group consisting of niacinamide, allantoin, maltooligosaccharide glucoside, hydrogenated starch hydrolysate, opuntia ficus-indica stem extract, sodium hyaluronate crosspolymer, jojoba esters, hydrolyzed jojoba esters, oleic acid, linoleic acid, linolenic acid, lactobionic acid, ursolic acid / sodium ursolic acid, nordihydroguaiaretic acid, ceramides, oligofructose, galactoarabinan, schizophyllan, myrtle leaf extract, swedish algae extract, saccharide isomerase, altermonas ferment extract, pseudoalteromonas ferment extract, corylus avellana leaf extract, emblica emblica fruit extract, birch juice, sugar cane extract, myrtle fruit extract, ginger flower root extract, angustifolia flower / leaf / stem extract, tremella fruiting body extract, alpha-glucan oligosaccharide, and any combination thereof;

[0154] Between about 0.05% to about 1.0% (% w / w) of one or more detoxifying agents including charcoal powder;

[0155] Between about 0.3% and about 18% (% w / w) of one or more cleaning agents selected from the group consisting of sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium xylene sulfonate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium 2-sulfolaurate, sodium myristyl polyoxyethylene ether sulfate, sodium xylene sulfonate, C 14-16 Sodium olefin sulfonate, C 14-16 Sodium alpha olefin sulfonate, disodium lauryl sulfosuccinate, sodium methyl cocoyl taurate, sodium cocoyl isethionate, sodium lauryl isethionate, sodium cocoyl sarcosinate, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, lauroyl sarcosine, cocoyl sarcosine, myristoyl sarcosine, oleoyl sarcosine, myristoyl / stearoyl sarcosine, sodium lauroyl glutamate, sodium cocoyl glutamate, disodium cocoyl glutamate, cocoyl glutamate, Lauroyl Glutamate, Potassium Cocoyl Glutamate, Potassium Lauroyl Glutamate, Potassium Myristoyl Glutamate, Sodium Myristoyl Glutamate, Sodium Stearoyl Glutamate, Disodium Stearoyl Glutamate, Sodium Palmitoyl Glutamate, Sodium Lauroyl Lactylate, Sodium Murumuru Palmoleate, Sodium Lauryl Glucoside Hydroxypropyl Sulfonate, Lauryl Glucoside Hydroxypropyl Citrate Disodium, Sodium Hydroxypropyl Sulfonate Lauryl Glucoside Crosspolymer, Dioctyl Sulfonate Succinate, Cocamidopropyl Hydroxysulfonate Betaine, Cocamidopropyl Betaine, Coco Betaine, Betaine, Cocoamphoacetate, Cocoamphodipropionate, Disodium Cocoamphodiacetate, Disodium Cocoamphodipropionate, Lauryl Betaine, Lauramidopropyl Betaine, Lauramidopropyl Hydroxysultaine, Lauryl Hydroxysultaine, Sodium Dilauramide Glutamine Lysine, Sodium Cocoamphopropionate, Lauroamphoacetate, Decyl glucoside, lauryl glucoside, cocoyl glucoside, cocoyl methyl glucoside, capryloyl / hexanoyl methyl glucoside, lauroyl / myristoyl methyl glucoside, cocamidopropylamine oxide, decylamine oxide, soapberry extract, saponin, lipopeptide, rape sophorolipid, potassium cocoyl hydrolyzed oat protein, Candida albicans / canola oil ferment, glycosides, glycolipids, rhamnolipids, phospholipids, sophorolipids, and any combination thereof; and

[0156] Between about 0.5% and about 28.0% (% w / w) of one or more cosmetically or dermatologically acceptable excipients selected from the group consisting of caprylic / capric / diglyceryl succinate, C14-16 glycol palmitate, C18-20 glycol isostearate, cocamidopropyl lauryl ether, dipentaerythritol hydroxystearate, dipentaerythritol hydroxyisostearate, dipentaerythritol hexacaprate / caprylate, palm kernel glycerides, lecithin, hydrogenated lecithin, phosphatidylcholine, C12-16 alcohols, palmitic acid, glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan olivate, cetearyl alcohol Olivate, Glyceryl Stearate Citrate, Sodium Stearoyl Lactylate, Sodium Stearoyl Glutamate, Sodium Cocoyl Glutamate, Caprylyl / Capryl Glucoside, Polyhydroxystearic Acid, Phenethyl Alcohol, Sodium Subtilisin, Polyglyceryl-3, Polyglyceryl-3 Distearate, Polyglyceryl-3 Diisostearate, Polyglyceryl-3 Cocoate, Polyglyceryl-3 Dicitrate / Stearate, Polyglyceryl-3 Beeswax, Polyglyceryl-3 Polyricinoleate, Polyglyceryl-4 Oleate, Polyglyceryl-4 Caprate, Polyglyceryl-4 Laurate, Polyglyceryl-6 Caprylate, Polyglyceryl-6 Stearate, Polyglyceryl-6 Distearate, Polyglyceryl-6 Behenate, Polyglyceryl-6 Polyhydroxystearate, Polyglyceryl-6 Oleate, Polyglyceryl-6 Ricinoleate, Poly Glyceryl-6 Polyricinoleate, Polyglyceryl-10 Laurate, Candelilla Wax / Jojoba / Rice Bran Polyglyceryl-3 Esters, Stearoyl Glutamate, Polysorbate 20, Polyglyceryl-10 Laurate, Polyglyceryl-6 Caprylate, Polyglyceryl-3 Cocoate, Polyglyceryl-4 Caprate, Polyglyceryl-6 Ricinoleate, Polyglyceryl-6 Caprylate, Sodium Subtilisin, Phytic Acid, Sodium Phytate, Caprylhydroxamic Acid, Trisodium Dicarboxymethyl Alanine, Gluconic Acid, Sodium Gluconate, Pentasodium Pentetate, Sodium Carboxymethyl Inulin, Tetrasodium Glutamate Diacetate, Trisodium Ethylenediamine Succinate, Sodium Thiosulfate, Diisopropyl Oxalate, Disodium EDTA, Disodium EDTA-Copper, HEDTA, Oxalic Acid, Potassium Citrate, Sodium Citrate, Sodium Oxalate, TEA-EDTA , Tetrasodium EDTA, Trisodium EDTA, Trisodium HEDTA, Benzoic Acid, Butylparaben, Diazolidinyl Urea, DMDM ​​Hydantoin, Ethylparaben, Imidazolidinyl Urea, Iodopropynyl Butylcarbamate, Isobutylparaben, Methylparaben, Methylchloroisothiazolinone, Methylisothiazolinone, Phenoxyethanol, Propylparaben, Sodium Benzoate, Potassium Sorbate, Ethylhexylglycerin, Gluconolactone, Laureth Lactate, Hydroxypropyl Starch Phosphate, Acrylates Copolymer, Ammonium Acryloyldimethyltaurate, Sodium Acryloyldimethyltaurate / VP Copolymer, Sodium Acrylate / Sodium Acryloyldimethyltaurate Copolymer, Sodium Polyacrylate, Polyacrylate Crosspolymer-11, Carbomer,Acrylates / C10-30 Alkyl Acrylate Crosspolymer, Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer, Lithium Magnesium Sodium Silicate, Sodium Magnesium Fluorosilicate, Ethylene Glycol Distearate, Hydrogenated Castor Oil, Hydrogenated Castor Oil Hydroxystearate, Hydrogenated Castor Oil Isostearate, Hydrogenated Castor Oil Stearate, Hydrogenated Castor Oil PEG-8 Esters, Quaternary Ammonium Compounds, Behentrimonium Chloride, Behentrimonium Methosulfate, Cetrimonium Chloride, Cetrimonium Methosulfate, Benzalkonium Chloride, Benzethonium Chloride, Cinnamyl Trimonium Chloride, Cocotrimonium Chloride, Dicetyl Dimonium Chloride, Dicocodimonium Chloride, Lauryl Trimonium Chloride, Stearamidopropyl Dimethylamine, Steartrimonium Chloride, Stearalkonium Chloride chloride), tricetyl dimonium chloride, PCA cocoyl arginine ethyl ester salt, C10-40 isoalkylamidopropyl ethyl dimethyl ammonium ethosulfate, dipalmitoyloxyethyl hydroxyethyl methyl ammonium methylsulfate, shea butter amidopropyl trimethyl ammonium chloride, xanthan gum, pullulan, algin, guar (tetragonoloba / guar) gum, sclerotium gum, senegal gum arabic, cellulose, cellulose gum, carboxymethyl cellulose Glucoside, Carbomer, Hydroxypropyl Starch Phosphate, Guar Hydroxypropyltrimonium Chloride, Carboxymethyl Hydroxyethyl Cellulose, Carboxymethyl Hydroxypropyl Guar Gum, Cellulose, Ethyl Cellulose, Hydroxybutyl Methyl Cellulose, Hydroxyethyl Cellulose, Hydroxymethyl Cellulose, Lauryl Polyglucose, L-Cysteine, 1,2,6-Hexanetriol, Dipropylene Glycol, Glycerin, Butylene Glycol, Caprylyl Glycol, Pentylene Glycol, Isopentyl Glycol, Hexylene Glycol, Panthenol, Phytantriol, 1,2-Propanediol, 1,3-Propanediol, Sodium PCA, Sorbitol, Triethylene Glycol, Polyglycerol Sorbitol, Glucose, Fructose, Mannitol, Xylitol, Inositol, Trehalose, Polydextrose, PCA Potassium, Hydrogenated Honey, Hyaluronic Acid, Inositol, Erythritol, Caprylyl Glycol, Acetamidoethoxyethanol, Polyquaternium-10, Polyquaternium-7, Polyquaternium-11, Polyquaternium-57, Quaternium-15, Quaternium-18, Quaternium-22, Quaternium-87, Guar Hydroxypropyltrimonium Chloride, Decyl Glucoside, Lauryl Glucoside, Cocoyl Glucoside, Cocoyl Methyl Glucosamide, Caprylyl / Caproyl Methyl glucamide, lauroyl / myristoyl methyl glucamide, cocamidopropylamine oxide, decylamine oxide, amodimethicone, amodimethicone, dimethiconecyclomethicone, cyclopentasiloxane, dimethicone, dimethicone copolyol,Dimethiconol, Hydrolyzed Wheat Protein Hydroxypropyl Polysiloxane, Trimethylsilyl Amodimethicone, Cocodimonium Hydroxypropyl Hydrolyzed Casein, Cocodimonium Hydroxypropyl Hydrolyzed Collagen, Cocodimonium Hydroxypropyl Hydrolyzed Hair Keratin, Cocodimonium Hydroxypropyl Hydrolyzed Keratin, Cocodimonium Hydroxypropyl Hydrolyzed Rice Protein, Cocodimonium Hydroxypropyl Hydrolyzed Silk, Cocodimonium Hydroxypropyl Hydrolyzed Soy Protein, Cocodimonium Hydroxypropyl Hydrolyzed Wheat Protein, Cocodimonium Hydroxypropyl Silk Amino Acids, Cocoyl Hydrolyzed Collagen, Cocoyl Hydrolyzed Keratin, Hydrolyzed Keratin, Hydrolyzed Oat Powder, Hydrolyzed Silk, Hydrolyzed Silk Protein, Hydrolyzed Soy Protein, Hydrolyzed Wheat protein, hydrolyzed quinoa, hydrolyzed elastin, hydrolyzed collagen, keratin, potassium cocoyl hydrolyzed collagen, retinol, retinyl palmitate, ascorbic acid, tocopherol, tocopheryl acetate, aloe barbadensis leaf extract, yucca schidigera leaf extract, yucca schidigera root extract, camellia sinensis leaf extract, equisetum arvense leaf extract, witch hazel leaf extract, giant kelp extract, isopropyl lauroyl sarcosinate, phenethyl benzoate, C12-15 alkyl benzoate, caprylic / capric triglyceride, cetyl caprylate, octyldodecanol, dilinoleic acid / 1,3-propylene glycol copolymer, isopentyl laurate, oleic acid, isohexadecane, squalane, isopropyl palmitate, polycitronellol, diheptyl succinate, caprylylglyceryl / sebacic acid copolymer, PPG-3 benzyl Ether Ethylhexanoate, Hydrogenated Vegetable Oil, Triheptanoin, Diisopropyl Sebacate, Diisopropyl Adipate, Propylene Glycol Dibenzoate, Propoxytetramethylpiperidinyl Dimethicone, Castor Oil / IPDI Copolymer, Butylene Glycol Cocoate, Butylene Glycol Dicaprylate / Dicaprate (Dispersant), Propylene Glycol Dicaprylate / Dicaprate, Triolein (Algae Oil), Propylene Glycol Dicaprylate / Dicaprate, Phytosteryl / Octyldodecyl Lauroyl Glutamate, C10-18 Triglycerides, Isostearyl Alcohol, Diisostearyl Malate, Isoamyl Laurate, *Isoamyl Cocoate, Hemi-Squalane, Polycitronellol Acetate, Ethyl Macadamia Oleate, Coconut Caprylate / Caprate, Coconut Alkanes, C9-12 Alkanes, C13-15 Alkanes, C13-16 Isoparaffin, Neopentyl Glycol Diheptanoate, Ethylhexyl Hydrogenated Olive Oil, Unsaponifiables of Hydrogenated Olive Oil, Undecane, Tridecane, Isododecane, Octyl Caprylate / Caprate, Cetyl Stearate, Cetearyl Stearate, Decyl Oleate, Glyceryl Stearate, Glyceryl Adipate, Glyceryl Arachidate, Glyceryl Arachidonate, Glyceryl Behenate, Glyceryl Caprate, Glyceryl Caprylate, Glyceryl Caprylate / Caprate, Glyceryl Citrate / Lactate / Linoleate / Oleate, Glyceryl Cocoate, Glyceryl Diarachidate, Glyceryl Dibehenate, Glyceryl Dierucate, Glyceryl Dihydroxystearate, Glyceryl Diisopalmitate, Glyceryl Diisostearate, Glyceryl Dilaurate, Glyceryl Dilinoleate, Glyceryl Dimyristate,Glyceryl dioleate, glyceryl dipalmitate, glyceryl dipalmitoleate, glyceryl diricinoleate, glyceryl distearate, glyceryl erucate, glycol stearate, isocetyl myristate, isopropyl palmitate, isopropyl stearate, isostearyl stearate, octyl palmitate, octyl stearate, propylene glycol dicaprylate / dicaprate, sorbitan benzoate, sorbitan caprylate, sorbitan isostearate, sorbitan laurate, Sorbitan tristearate, stearyl stearate, tocopheryl linoleate, olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, sesame seed oil, apricot kernel oil, crambe seed oil, rice bran oil, grape seed oil, passionflower seed oil, meadowfoam seed oil, shea butter, sauvignon blanc seed butter, star fruit palm butter, carnosine, tetrahexyldecyl ascorbate, bioflavonoids, lycopene, carrot root fine Cell culture lysate, monoammonium glycyrrhizinate, alpha lipoic acid (lipoic acid), edelweiss alpina (leontopodium alpinum) extract, rosemary leaf extract (WS), grape seed extract, camellia sinensis (tea) extract, quercetin (orange) wood extract, hydrolyzed olive fruit, oleaster (olive) leaf extract, oleuropein, pomegranate bark / fruit extract, punicalagin, ellagic acid, polyphenols, epigallocatechin-3-glucan (EGCG), tannins, sulforaphane, resveratrol, nordihydroguaiac Acid, ascorbic acid, citric acid, lactic acid, glycolic acid, tartaric acid, malic acid, L-arginine, potassium hydroxide, sodium hydroxide, triethanolamine, sodium bicarbonate, calcium chloride, magnesium chloride, magnesium sulfate, potassium chloride, potassium glycol sulfate, sodium chloride, lauric acid, palmitic acid, stearic acid, arachidyl alcohol, behenyl alcohol, cetearyl alcohol, cetyl alcohol, isocetyl alcohol, isostearyl alcohol, lauryl alcohol, myristyl alcohol, stearyl alcohol, C30-50 alcohols, lanolin alcohol, and any combination thereof;

[0157] wherein the one or more peptides comprise a peptide sequence comprising SEQ ID NO:75, SEQ ID NO:400, SEQ ID NO:401, SEQ ID NO:402, SEQ ID NO:409, SEQ ID NO:412, SEQ ID NO:432, SEQ ID NO:1131 or a combination thereof.

[0158] Example

[0159] The following examples are included for illustrative purposes only and are not intended to limit the scope of the present invention.

[0160] Example 1. Preparation of a detoxifying hair and scalp cleanser

[0161] Exemplary detoxifying hair and scalp cleansing compositions are provided in Tables 2-6. Exemplary detoxifying hair and scalp cleansing compositions are prepared by conventional formulation and mixing techniques, or by mixing together one or more polyols (e.g., glycerol), water, and surfactants, and any solids that need to be melted at elevated temperatures. The ingredients are thoroughly mixed at elevated temperatures, and then cooled to ambient temperature. Additional ingredients are added to the cooled product. Unless otherwise indicated, the amounts reflect the weight percentages of active substances.

[0162] Table 2. Exemplary Detoxifying Hair and Scalp Cleanser Compositions

[0163]

[0164]

[0165] Table 3. Exemplary Detoxifying Hair and Scalp Cleanser Compositions

[0166]

[0167]

[0168] Table 4. Exemplary Detoxifying Hair and Scalp Cleanser Compositions

[0169]

[0170] Table 5. Exemplary Detoxifying Hair and Scalp Cleanser Compositions

[0171]

[0172] Table 6. Exemplary Detoxifying Hair and Scalp Cleanser Compositions

[0173]

[0174]

[0175] Example 2. Evaluation of the efficacy of detoxifying hair and scalp cleansers during and after cleansing

[0176] A detoxifying hair and scalp cleanser composition was prepared according to Example 1. The detoxifying hair and scalp cleanser composition was evaluated using a survey to determine the sensory effects of the detoxifying hair and scalp cleanser on shine, texture (i.e., smoothness), bounce, and firmness. The sensory effects were evaluated during the cleansing process and after drying.

[0177] A human hair tress having a length of 25 cm, a width of 5.5 cm, and a weight of 10 g was gently rinsed with warm water at 40°C. Excess moisture was removed, and the tress was fully foamed for about 1 minute, using 1.5 g of the detoxifying hair and scalp cleanser composition per 10 g of the tress. The foamed hair was subjected to a sensory evaluation to determine its smoothness. 20 people performed the evaluation, and the total evaluation value is shown. The evaluation criteria were: 4: good sliding, 3: slight sliding, 2: not very good sliding, and 1: no sliding.

[0178] A human hair tress of 25 cm in length, 5.5 cm in width, and 10 g in weight was gently rinsed with warm water at 40°C. Excess moisture was removed, and the tress was fully foamed for about 1 minute, using 1.5 g of the detoxifying hair and scalp cleanser composition per 10 g of the tress. The foamed hair was rinsed with tap water (2 L / min) at 40°C for 1 minute. Excess moisture was removed with a towel and the tress was air-dried. After drying, the dry hair was subjected to a sensory evaluation to determine its glossiness and uniformity. 20 people performed the evaluation, and the total evaluation value is shown. The evaluation criteria are: 4: good, 3: slightly good, 2: not very good, and 1: not good.

[0179] A tress of human hair having a length of 25 cm, a width of 5.5 cm, and a weight of 10 g was thoroughly rinsed with warm water at 40°C. The tress was thoroughly foamed for about 1 minute using 5 g or 10 g of the detoxifying hair and scalp cleanser composition. The foamed hair was thoroughly rinsed with tap water at 40°C (2 L / min). Excess moisture was removed using a towel and the tress was dried with warm air from a hair dryer. After drying, the dry hair was subjected to a sensory evaluation to determine its elasticity. 25 people performed the evaluation, and the total evaluation value is shown. The evaluation criteria were: 4: significant improvement in elasticity, 3: visible improvement in elasticity and hardness, 2: slight improvement in elasticity, 1: no improvement in elasticity, and 0: loss of elasticity.

[0180] Example 3. Evaluation of cleaning efficacy using FTIR

[0181] Bleached hair samples can be obtained. Some of the bleached hair samples can be treated with the detoxifying hair and scalp cleanser composition described herein. For the treated and untreated samples, cross sections will be prepared using a cryostat, and the cross sections will be examined using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR). Using this technology, a hyperspectral image will be generated, which can be used to visualize the lipid content within the hair fiber, assess hair damage (i.e., chemical treatment or UV exposure) within the hair fiber, identify modifications in the hair structure (i.e., protein conformation or lipid organization), evaluate the hydration of the hair (i.e., water content), visualize active penetration within the hair fiber, and determine the efficacy of the cleanser in removing sebum and deposits on the hair strands.

[0182] ATR-FTIR can be used to scan individual fibers of treated and untreated samples longitudinally, which can provide infrared images of approximately the outer 1-2 microns of the fiber surface. These hyperspectral images can be used to determine lipid content in the cuticle, study hair damage along the fiber (i.e., chemical treatment or UV exposure), analyze the deposition of active ingredients along the hair fiber, identify changes in hair structure (i.e., protein conformation or lipid organization), evaluate hair hydration (i.e., water content), and determine the efficacy of cleansers and products in removing sebum from the hair strands.

[0183] Example 4: Evaluation of Metal Reduction / Chelation

[0184] Bleached hair samples can be obtained. Some of the bleached hair samples can be treated with the detoxifying hair and scalp cleanser compositions described herein. Treated and untreated samples can be rinsed with hard water and examined using time-of-flight secondary ion mass spectrometry (TOF-SIMS). Spectra of calcium, magnesium, copper, aluminum, iron, chromium, zinc, nickel, cadmium, lead, and mercury can be obtained.

[0185] ***

[0186] Although preferred embodiments of the present invention have been shown and described herein, it will be apparent to those skilled in the art that such embodiments are provided by way of example only. The present invention is not intended to be limited by the specific embodiments provided in the specification. Although the present invention has been described with reference to the foregoing description, the description and illustration of the embodiments herein are not meant to be limiting. Now those skilled in the art will conceive of many variations, changes and substitutions without departing from the present invention. In addition, it should be understood that all aspects of the present invention are not limited to the specific description, configuration or relative proportions set forth herein according to various conditions and variables. It should be understood that in practicing the present invention, various alternatives to the embodiments of the present invention described herein may be adopted. Therefore, it is contemplated that the present invention should also encompass any such alternatives, modifications, variations or equivalents. The appended claims are intended to define the scope of the present invention, and are intended to therefore encompass methods and structures within the scope of these claims and their equivalents.

Claims

1. A detoxifying hair and scalp cleanser comprising: one or more solvents; one or more peptides; one or more hair conditioners; one or more skin conditioning substances; one or more detoxifying agents; one or more cleaning agents; and one or more cosmetically or dermatologically acceptable excipients; wherein the one or more peptides comprise a peptide sequence comprising SEQ ID NO:75, SEQ ID NO:400, SEQ ID NO:401, SEQ ID NO:402, SEQ ID NO:409, SEQ ID NO:412, SEQ ID NO:432, SEQ ID NO:1131, or a combination thereof.

2. The cleanser of claim 1, wherein the concentration (% w / w) of the one or more peptides in the hair and scalp cleanser is between about 0.0001% and about 1%.

3. The cleanser of claim 1, wherein the one or more hair conditioners are selected from the group consisting of panthenol, salicylic acid, raspberry leaf extract, safflower seed extract, hydroxypropyl glucamide, hydroxypropyl ammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or combinations thereof.

4. The cleanser of claim 1, wherein the one or more skin conditioners are selected from caprylyl glycol, maltooligosaccharide glucoside, hydrogenated starch hydrolysate, Opuntia ficus-indica stem extract, saccharide isomerase, alpha-glucan oligosaccharide, Alteromonas fermentation extract, Myrtus foeniculum leaf extract, guar hydroxypropyltrimonium chloride, or a combination thereof.

5. The cleaning article of claim 1, wherein the one or more detoxifying agents are absorbents.

6. The cleaning article according to claim 5, wherein the absorbent is charcoal powder.

7. The cleaning article of claim 1, wherein the one or more cleaning agents are surfactants.

8. The cleaning article according to claim 7, wherein the surfactant is selected from the group consisting of anionic surfactants, amphoteric surfactants, nonionic surfactants, biosurfactants or combinations thereof.

9. The cleaning article according to claim 8, wherein the surfactant comprises at least one anionic surfactant selected from the group consisting of sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium xylene sulfonate, C 14-16 Sodium olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myristyl ether sulfate, sodium xylene sulfonate, TEA dodecylbenzene sulfonate, ethyl PEG-15 cocoamine sulfate, sodium dioctyl sulfosuccinate, or a combination thereof.

10. The cleaning article according to claim 8, wherein the surfactant comprises at least one amphoteric surfactant selected from the group consisting of cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate or a combination thereof.

11. The cleanser of claim 1 , wherein the one or more cosmetically or dermatologically acceptable excipients are selected from the group consisting of: humectants, chelating agents, buffering agents, or preservatives, or combinations thereof.

12. The cleaning article according to claim 11, wherein the humectant is selected from the group consisting of glycerin, 1,2-propylene glycol, 1,3-propylene glycol, and isopentyl glycol.

13. The hair and scalp cleanser of claim 11, wherein the chelating agent is selected from the group consisting of sodium phytate, EDTA, sodium gluconate, trisodium dicarboxymethylalanine, tetrasodium glutamate diacetate, or caprylhydroxamic acid, or a combination thereof.

14. The cleaning article of claim 11, wherein the buffer is selected from the group consisting of citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L-arginine, sodium hydroxide, potassium hydroxide, or a combination thereof.

15. The cleaning article according to claim 11, wherein the preservative is selected from the group consisting of phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination thereof.

16. The cleaning article of any one of the preceding claims, wherein the concentration (% w / w) of the one or more solvents in the cleaning article is between about 50% and about 90%.

17. The cleanser of any of the preceding claims, wherein the concentration (% w / w) of the one or more hair conditioners in the cleanser is between about 0.01% and about 10%.

18. The cleanser of any of the preceding claims, wherein the concentration (% w / w) of the one or more skin conditioners in the cleanser is between about 0.01% to about 5%.

19. A cleaning article as claimed in any one of the preceding claims, wherein the concentration (% w / w) of the one or more cleaning agents in the cleaning article is between about 0.1% and about 20%.

20. The cleanser of any of the preceding claims, wherein the concentration (% w / w) of the one or more cosmetically or dermatologically acceptable excipients in the cleanser is between about 0.1% and about 30%.

21. The cleaning composition of any one of the preceding claims, wherein the pH of the cleaning composition is between about 4 and about 6.

22. A method for cleaning hair using the cleaning article according to any one of claims 1 to 21.

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