Composition for improving stability of 4-butylresorcinol, application of composition and external skin preparation

Abstract

The invention discloses a composition for improving the stability of 4-butylresorcinol, application of the composition and an external skin preparation, and belongs to the technical field of cosmetics. The composition is prepared from the following components in parts by weight: 0.01 to 5 parts of 4-butyl resorcinol, 0.005 to 0.195 part of sodium pyrosulfite, 0.005 to 0.195 part of sodium hydrogen sulfite, 0.005 to 3 parts of ergothioneine and 0.003 to 0.2 part of troxerutin. The composition can maintain the 4-butylresorcinol not to change color for a long time, and especially can maintain the original color under the conditions of ultraviolet irradiation and light irradiation for 3 months. The composition is used for preparing the external skin preparation, so that the external skin preparation also has better color stability, and the product quality of the external skin preparation is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a composition for improving the stability of 4-butylresorcinol and an application thereof and an external skin preparation. Background Art

[0002] As consumers' demand for whitening products continues to grow, the cosmetics industry is increasingly pursuing efficient and safe whitening ingredients. 4-Butylresorcinol occupies an important position in the field of whitening cosmetics due to its unique chemical structure, significant whitening effect and good safety.

[0003] In the field of whitening skin care, the whitening mechanism of 4-butylresorcinol is mainly reflected in inhibiting melanin synthesis, promoting melanin metabolism and cooperating with other whitening ingredients.

[0004] Regarding the inhibition of melanin synthesis, 4-butylresorcinol can deeply act on multiple key links of melanin production. In the process of melanin synthesis, tyrosinase plays a vital role. It catalyzes the oxidation of dopa to dopaquinone, which is then converted into intermediate products such as dopachrome, and finally forms melanin. 4-butylresorcinol can effectively inhibit the activity of tyrosinase, thereby reducing the production of dopaquinone and subsequent products, fundamentally blocking the synthesis path of melanin. This inhibitory effect is comprehensive and targeted, making 4-butylresorcinol occupy an important position in whitening skin care products.

[0005] 4-Butylresorcinol also shows significant effects in promoting melanin metabolism. It not only inhibits the production of new melanin, but also accelerates the transfer of the generated melanin to the stratum corneum. With the metabolism of epidermal cells, these melanins will eventually be excreted from the body, thus achieving rapid metabolism of melanin. This process is of great significance for improving skin problems such as uneven skin tone and fading spots.

[0006] However, 4-butylresorcinol is very easy to change color, which has a great impact on products that need to maintain color stability.

[0007] In view of this, the present invention is proposed. Summary of the invention

[0008] The object of the present invention is to provide a composition for improving the stability of 4-butylresorcinol and its application and external skin preparation, so as to solve or improve the above technical problems.

[0009] The present invention can be implemented like this: In a first aspect, the present invention provides a composition for improving the stability of 4-butylresorcinol. The composition comprises, by weight, 0.01 to 5 parts of 4-butylresorcinol, 0.005 to 0.195 parts of sodium pyrosulfite, 0.005 to 0.195 parts of sodium bisulfite, 0.005 to 3 parts of ergothioneine and 0.003 to 0.2 parts of troxerutin.

[0010] In a second aspect, the present invention provides a use of the composition according to the aforementioned embodiment in preparing an external skin preparation.

[0011] In a third aspect, the present invention provides an external skin preparation, wherein the raw materials for preparing the external skin preparation include the composition of the aforementioned embodiment.

[0012] In an alternative embodiment, the topical skin preparation comprises a cosmetic product.

[0013] In an optional embodiment, the dosage form of the cosmetic includes any one of an aqueous solution, an emulsion, a spray, a cream, an essence, and a mask.

[0014] In an optional embodiment, the cosmetic contains, by mass percentage, 0.01% to 5% of 4-butylresorcinol, 0.005% to 0.195% of sodium metabisulfite, 0.005% to 0.195% of sodium bisulfite, 0.005% to 3% of ergothioneine, and 0.003% to 0.2% of troxerutin.

[0015] In an optional embodiment, the cosmetic is a facial cream, and the raw materials for preparing the facial cream also include auxiliary materials; the auxiliary materials include at least one of a preservative, a thickener, a moisturizer, an emulsifier, an emollient and a skin conditioner.

[0016] In an optional embodiment, in terms of mass percentage, the content of preservatives in the raw materials for preparing the facial cream is 0.05%~7%; and / or, the content of thickeners in the raw materials for preparing the facial cream is 0.05%~2%; and / or, the content of moisturizers in the raw materials for preparing the facial cream is 1%~15%; and / or, the content of emulsifiers in the raw materials for preparing the facial cream is 0.5%~6.5%; and / or, the content of emollients in the raw materials for preparing the facial cream is 1%~10%; and / or, the content of skin conditioners in the raw materials for preparing the facial cream is 0.1%~5%.

[0017] In an optional embodiment, the preservative includes at least one of pentylene glycol, 1,2-hexanediol, p-hydroxyacetophenone, caprylyl glycol, ethylhexylglycerin, chlorphenesin and phenoxyethanol; and / or, the thickener comprises at least one of carbomer, xanthan gum, cellulose, acrylic acid (esters) / C10-30 alkyl acrylate crosspolymer, ammonium acryloyldimethyl taurate / VP copolymer, sodium acrylate / sodium acryloyldimethyl taurate and hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer; and / or, the moisturizing agent comprises at least one of glycerin, butylene glycol, 1,3-propylene glycol, dipropylene glycol, xylitol and glyceryl polyether-26; and / or, the emulsifier includes at least one of sodium stearoyl lactylate, higher alcohols, glyceryl stearate, sorbitan laurate, and glyceryl oleate citrate; and / or, the emollient comprises at least one of dimethicone, butylene glycol dicaprylate / dicaprate, isononyl isononanoate, squalane, and caprylic / capric triglyceride; And / or, the skin conditioning agent includes at least one of panthenol, ectoine, bisabolol, niacinamide, campestrol and yeast fermentation extract.

[0018] In an optional embodiment, the raw materials for preparing the facial cream include, by mass percentage, 0.01% to 5% of 4-butylresorcinol, 0.005% to 0.195% of sodium metabisulfite, 0.005% to 0.195% of sodium bisulfite, 0.005% to 3% of ergothioneine, 0.003% to 0.2% of troxerutin, 7% to 8% of butanediol, 0.08% to 0.12% of xanthan gum, 0.45% to 0.55% of Ammonium acryloyldimethyltaurate / VP copolymer, 4.5%~5.5% pentylene glycol, 0.45%~0.55% 1,2-hexanediol, 1.9%~2.0% glyceryl stearate, 0.25%~0.35% sodium stearoyl lactylate, 3.5%~4.0% cetearyl alcohol, 5.5%~6.5% butylene glycol dicaprylate / dicaprate and 2.5%~3.5% polydimethylsiloxane, and the balance is solvent.

[0019] In an alternative embodiment, the solvent comprises at least one of a polyol and water.

[0020] In an alternative embodiment, the polyol includes at least one of glycerol, butylene glycol and propylene glycol.

[0021] In an optional embodiment, the preparation method of the facial cream comprises: According to the proportion, glyceryl stearate, sodium stearoyl lactylate, cetearyl alcohol, butylene glycol dicaprylate / dicaprate and polydimethicone are mixed at 80° C. to 90° C. for 8 min to 15 min to obtain phase A; According to the ratio, xanthan gum, ammonium acryloyldimethyltaurate / VP copolymer and butanediol were mixed, and then pentanediol, 1,2-hexanediol and water were added, and mixed at 85°C to 95°C for 25min to 35min to obtain phase B; Add phase A to phase B and homogenize at 6500r / min~7500r / min for 4min~6min; After cooling to 35°C-40°C, add the composition consisting of 4-butylresorcinol, sodium pyrosulfite, sodium bisulfite, ergothioneine and troxerutin and stir evenly.

[0022] The beneficial effects of the present invention include: In the combination provided by the present invention, sodium pyrosulfite, sodium bisulfite and ergothioneine are mainly used to play an antioxidant role. Troxerutin can play an antioxidant role and can also play a role of a light protectant. The present invention creatively proposes a composition after specific components are compounded according to a specific ratio, and the composition can play a good color stabilization effect on 4-butylresorcinol, especially improve the color stability of 4-butylresorcinol under long-term ultraviolet irradiation and light irradiation.

[0023] The external skin preparation containing the above composition can have good color stability over a long period of time, which is beneficial to improving the product quality of the external skin preparation. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for use in the embodiments are briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without creative work.

[0025] Figure 1 This is the result chart corresponding to 90 days after the color stability test of the cream samples corresponding to Application Examples 1 to 5 in Test Example 2; Figure 2 This is the result chart corresponding to 90 days after the color stability test of the cream samples corresponding to Application Examples 6 to 10 in Test Example 2; Figure 3 This is the result chart corresponding to 90 days after the color stability test of the cream samples corresponding to Application Examples 11 to 15 in Test Example 2; Figure 4 This is the result chart corresponding to 90 days after the color stability test of the cream samples corresponding to Application Examples 16 to 20 in Test Example 2. DETAILED DESCRIPTION

[0026] In order to make the purpose, technical scheme and advantages of the embodiments of the present invention clearer, the technical scheme in the embodiments of the present invention will be described clearly and completely below. If the specific conditions are not specified in the embodiments, they are carried out according to conventional conditions or conditions recommended by the manufacturer. If the manufacturer of the reagents or instruments used is not specified, they are all conventional products that can be purchased commercially.

[0027] The composition for improving the stability of 4-butylresorcinol provided by the present invention, its application and external skin preparation are specifically described below.

[0028] The invention provides a composition for improving the stability of 4-butylresorcinol. The composition comprises, by weight, 0.01 to 5 parts of 4-butylresorcinol, 0.005 to 0.195 parts of sodium pyrosulfite, 0.005 to 0.195 parts of sodium bisulfite, 0.005 to 3 parts of ergothioneine and 0.003 to 0.2 parts of troxerutin.

[0029] Among them, the amount of 4-butylresorcinol can be 0.01 parts, 0.05 parts, 0.1 parts, 0.5 parts, 1 parts, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts, etc., or other values ​​within the range of 0.01 parts to 5 parts.

[0030] The amount of sodium metabisulfite used can be 0.005 parts, 0.01 parts, 0.05 parts, 0.1 parts, 0.15 parts or 0.195 parts, etc., or other values ​​within the range of 0.005 parts to 0.195 parts.

[0031] The amount of sodium bisulfite used can be 0.005 parts, 0.01 parts, 0.05 parts, 0.1 parts, 0.15 parts or 0.195 parts, etc., or other values ​​within the range of 0.005 parts to 0.195 parts.

[0032] The consumption of ergothioneine can be 0.005 part, 0.01 part, 0.05 part, 0.1 part, 0.5 part, 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts etc., and can also be other values ​​within the scope of 0.005 part ~ 3 parts.

[0033] The dosage of troxerutin can be 0.003 parts, 0.005 parts, 0.01 parts, 0.05 parts, 0.1 parts, 0.15 parts or 0.2 parts, etc., or other values ​​within the range of 0.003 parts to 0.2 parts.

[0034] By combining 4-butylresorcinol, sodium pyrosulfite, sodium bisulfite, ergothioneine and troxerutin according to the above preferred ratio, 4-butylresorcinol can have better color stability.

[0035] In the present invention, sodium pyrosulfite, sodium bisulfite and ergothioneine are mainly used to play an antioxidant role. Troxerutin can play an antioxidant role and also play a role of a light protectant.

[0036] It should be noted that not all antioxidants and light protectants can have a good color stabilization effect on 4-butylresorcinol, especially under the conditions of ultraviolet irradiation and light irradiation for 3 months, the original color can still be maintained. The component selection and ratio relationship of the composition provided by the present invention are obtained after the inventors have made creative efforts. By compounding the above five components according to the above proportions, the discoloration of 4-butylresorcinol due to oxidation to generate aldehyde-like substances can be avoided, and the color stability of 4-butylresorcinol under long-term ultraviolet irradiation and light irradiation can also be improved.

[0037] Correspondingly, the present invention also provides a method for preparing the above-mentioned composition. Specifically, 4-butylresorcinol, sodium pyrosulfite, sodium bisulfite, ergothioneine and troxerutin are mixed according to a preset ratio.

[0038] In addition, the present invention also provides the use of the composition in preparing external skin preparations.

[0039] Accordingly, the present invention also provides an external skin preparation, the raw materials for preparing the external skin preparation include the above composition.

[0040] The above-mentioned external skin preparations may include cosmetics (such as makeup products and facial care products), and may also include body care products and cleaning products, etc.

[0041] The dosage forms of cosmetics may illustratively but not limitatively include aqueous solutions, emulsions, sprays, creams, essences, and facial masks.

[0042] When the external skin preparation is a cosmetic, the cosmetic may contain, calculated by mass percentage, 0.01%~5% of 4-butylresorcinol, 0.005%~0.195% of sodium metabisulfite, 0.005%~0.195% of sodium bisulfite, 0.005%~3% of ergothioneine and 0.003%~0.2% of troxerutin.

[0043] It should be noted that due to the defect that 4-butylresorcinol is easy to change color, the amount of 4-butylresorcinol added in cosmetics is usually low. However, the composition provided by the present invention can effectively maintain good color stability of the product and avoid product discoloration when the amount of 4-butylresorcinol added reaches more than 2% (such as 2% to 5%).

[0044] In some optional embodiments, taking the cosmetic as a facial cream as an example, the raw materials for preparing the facial cream include auxiliary materials in addition to the above-mentioned composition.

[0045] The auxiliary material may exemplarily but not limitatively include at least one of a preservative, a thickener, a moisturizer, an emulsifier, an emollient and a skin conditioner. In addition, other auxiliary materials available in the art may also be added according to actual needs.

[0046] In some optional embodiments, in terms of mass percentage, the content of preservatives in the raw materials for preparing the cream can be 0.05% to 7%, such as 0.05%, 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6% or 7%, etc. The content of thickeners in the raw materials for preparing the cream can be 0.05% to 2%, such as 0.05%, 0.1%, 0.5%, 1%, 1.5% or 2%, etc. The content of moisturizers in the raw materials for preparing the cream can be 1% to 15%, such as 1%, 2%, 5%, 8%, 10%, 12% or 15%, etc. The content of emulsifiers in the raw materials for preparing the cream can be 0.5% to 6.5%, such as 0.5%, 1%, 2%, 3%, 4%, 5%, 6% or 6.5%, etc. The content of emollients in the raw materials for preparing the cream can be 1% to 10%, such as 1%, 2%, 5%, 8% or 10%, etc. The content of the skin conditioner in the raw materials for preparing the face cream can be 0.1% to 5%, such as 0.1%, 0.5%, 1%, 2%, 3%, 4% or 5%.

[0047] By way of example, the preservative may illustratively but not limitingly include at least one of pentylene glycol, 1,2-hexanediol, p-hydroxyacetophenone, caprylyl glycol, ethylhexylglycerin, chlorphenesin, and phenoxyethanol.

[0048] The thickener may illustratively but not limitatively include at least one of carbomer, xanthan gum, cellulose, acrylates / C10-30 alkyl acrylate crosspolymer, ammonium acryloyldimethyl taurate / VP copolymer, sodium acrylate / sodium acryloyldimethyl taurate, and hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer.

[0049] The moisturizer may illustratively but not limitatively include at least one of glycerin, butylene glycol, 1,3-propylene glycol, dipropylene glycol, xylitol, and glycereth-26.

[0050] The emulsifier may illustratively but not limitatively include at least one of sodium stearoyl lactylate, higher alcohols, glyceryl stearate, sorbitan laurate, and glyceryl oleate citrate.

[0051] The emollient may illustratively but not limitatively include at least one of dimethicone, butylene glycol dicaprylate / dicaprate, isononyl isononanoate, squalane, and caprylic / capric triglyceride.

[0052] The skin conditioning agent may illustratively but not limitatively include at least one of panthenol, ectoine, bisabolol, niacinamide, campesterols, and yeast fermentation extract.

[0053] In some typical embodiments, the raw materials for preparing the cream may include, by mass percentage, 0.01% to 5% (e.g., 0.01%, 1%, 2%, 3%, 4%, 5%, etc.) of 4-butylresorcinol, 0.005% to 0.195% (e.g., 0.005%, 0.05%, 0.06%, 0.1% or 0.195%) of sodium metabisulfite, 0.005% to 0.195% (e.g., 0.005%, 0.03%, 0.08%, 0.1% or 0.195%) of sodium bisulfite, 0.005% to 3% (e.g., 0.00 5%, 0.04%, 0.1%, 0.22% or 3%, etc.) of ergothioneine, 0.003%~0.2% (such as 0.003%, 0.05%, 0.16%, 0.1% or 0.2%, etc.) of troxerutin, 7%~8% (such as 7%, 7.5% or 8%) of butanediol, 0.08%~0.12% (such as 0.08%, 0.09%, 0.1%, 0.11% or 0.12%, etc.) of xanthan gum, 0.45%~0.55% (such as 0.45%, 0.48%, 0.50%, 0.52% or 0.55%, etc.) of propylene Ammonium dimethyl taurate / VP copolymer, 4.5%~5.5% (such as 4.5%, 4.8%, 5.0%, 5.2% or 5.5%) of pentylene glycol, 0.45%~0.55% (such as 0.45%, 0.48%, 0.50%, 0.52% or 0.55%) of 1,2-hexanediol, 1.9%~2.0% (such as 1.9%, 1.95% or 2.0%) of glyceryl stearate, 0.25%~0.35% (0.25%, 0.28%, 0.30%, 0.32% or 0.35%) of stearoyl lactylate Sodium, 3.5% to 4.0% (such as 3.5%, 3.6%, 3.7%, 3.8%, 3.9% or 4.0%) of cetearyl alcohol, 5.5% to 6.5% (such as 5.5%, 5.8%, 6.0%, 6.2% or 6.5%) of butylene glycol dicaprylate / dicaprate, 2.5% to 3.5% (such as 2.5%, 2.8%, 3.0%, 3.2% or 3.5%) of polydimethylsiloxane and 4% to 4.5% (such as 4%, 4.1%, 4.2%, 4.3%, 4.4% or 4.5%) of the composition, and the balance is solvent.

[0054] The solvent may illustratively but not limitatively include at least one of polyol and water, wherein the polyol may include at least one of glycerol, butylene glycol and propylene glycol.

[0055] In some more typical embodiments, the raw materials for preparing the facial cream include, by mass percentage, 2% 4-butylresorcinol, 0.1% sodium metabisulfite, 0.1% sodium bisulfite, 0.1% ergothioneine, 0.1% troxerutin, 8% butylene glycol, 0.10% xanthan gum, 0.50% ammonium acryloyldimethyltaurate / VP copolymer, 5.0% pentylene glycol, 0.50% 1,2-hexanediol, 1.95% glyceryl stearate, 0.30% sodium stearoyl lactylate, 3.8% cetearyl alcohol, 6.0% butylene glycol dicaprylate / dicaprate, 3.0% polydimethylsiloxane and 4.5% of the composition, and the balance is water.

[0056] In some optional embodiments, the method for preparing the facial cream comprises: S1: According to the proportion, glyceryl stearate, sodium stearoyl lactylate, cetearyl alcohol, butylene glycol dicaprylate / dicaprate and polydimethylsiloxane are mixed at 80°C to 90°C (such as 80°C, 82°C, 85°C, 88°C or 90°C, etc.) for 8min to 15min to obtain phase A; S2: xanthan gum, ammonium acryloyldimethyltaurate / VP copolymer and butanediol are mixed according to the proportion, and then pentanediol, 1,2-hexanediol and water are added, and mixed at 85°C to 95°C (such as 85°C, 88°C, 90°C, 92°C or 95°C, etc.) for 25min to 35min (such as 25min, 28min, 30min, 32min or 35min, etc.) to obtain phase B; S3: Add phase A to phase B and homogenize at 6500 r / min~7500 r / min (such as 6500 r / min, 6800 r / min, 7000 r / min, 7200 r / min or 7500 r / min, etc.) for 4 min~6 min (such as 4 min, 5 min or 6 min, etc.); S4: After cooling to 35°C~40°C (such as 35°C, 38°C or 40°C, etc.), add the composition and stir evenly.

[0057] The features and performance of the present invention are further described in detail below in conjunction with the embodiments.

[0058] Example 1 This embodiment provides a composition, which includes, by weight, 2 parts of 4-butylresorcinol, 0.1 parts of sodium pyrosulfite, 0.1 parts of sodium bisulfite, 0.1 parts of ergothioneine and 0.1 parts of troxerutin.

[0059] Embodiment 2~5 The difference between Examples 2 to 5 and Example 1 is only that the composition ratios of the compositions are different. Please refer to Table 1 for details.

[0060] Comparative Examples 1 to 11 The difference between Comparative Examples 1 to 11 and Example 1 is only that the composition ratios of the compositions are different. Please refer to Table 1 for details.

[0061] Comparative Example 12 The difference between this comparative example and Example 1 is: ergothioneine is replaced with tocopherol in equal amounts.

[0062] Comparative Example 13 The difference between this comparative example and Example 1 is that troxerutin is replaced by an equal amount of benzophenone-4.

[0063] Comparative Example 14 The difference between this comparative example and Example 1 is that sodium metabisulfite is replaced by an equal amount of butylated hydroxytoluene.

[0064] Comparative Example 15 The difference between this comparative example and Example 1 is that sodium bisulfite is replaced by an equal amount of glutathione.

[0065] Table 1 Group distribution ratio table

[0066] Application Example 1 This application example provides a facial cream. The raw materials for preparing the facial cream include, by mass percentage, 2% 4-butylresorcinol, 0.1% sodium pyrosulfite, 0.1% sodium bisulfite, 0.1% ergothioneine, 0.1% troxerutin (i.e., the composition provided in Example 1), 8% butylene glycol, 0.10% xanthan gum, 0.50% ammonium acryloyldimethyltaurate / VP copolymer, 5.0% pentylene glycol, 0.50% 1,2-hexanediol, 1.95% glyceryl stearate, 0.30% sodium stearoyl lactylate, 3.8% cetearyl alcohol, 6.0% butylene glycol dicaprylate / dicaprate and 3.0% polydimethylsiloxane, and the balance is water.

[0067] The preparation of the cream includes: S1: According to the proportion, glyceryl stearate, sodium stearoyl lactylate, cetearyl alcohol, butylene glycol dicaprylate / dicaprate and polydimethicone were mixed at 85° C. for 10 minutes to obtain phase A; S2: xanthan gum, ammonium acryloyldimethyltaurate / VP copolymer and butanediol were mixed according to the ratio, and then pentanediol, 1,2-hexanediol and water were added, and mixed at 90°C for 30 minutes to obtain phase B; S3: Add phase A to phase B and homogenize at 7000r / min for 5min; S4: After cooling to 40° C., add the composition of Example 1 and stir evenly.

[0068] Application Examples 2~20 The difference between Application Examples 2 to 20 and Application Example 1 is that the compositions in the Application Examples are replaced with the compositions provided in Examples 2 to 5 and Comparative Examples 1 to 15 in sequence.

[0069] Test Example 1 The compositions provided in Examples 1 to 5 and Comparative Examples 1 to 15 were tested for color stability.

[0070] Test conditions: UV light and LED light were used simultaneously in a Binder KBF720 LQC constant temperature and humidity chamber system. The UV light had an illumination of 0.9 W·hr / m per hour. 2 The LED lamp had an illumination of 7000LUX·hr per hour and was subjected to a stability test for 3 months (90 days) under non-dark conditions.

[0071] After the test, the products were taken out for color comparison, and the results are shown in Table 2.

[0072] Table 2 Test results

[0073] Note: *Level 1: no color change; **Level 2: faint pink or faint yellow, not obvious; ***Pink or yellow, obvious; ****Pink, relatively obvious; *****Pink-yellow, very obvious.

[0074] As can be seen from Table 2, the composition provided by the embodiment of the present invention can have higher color stability than the composition provided by the comparative example.

[0075] By comparing Example 1 with Comparative Examples 2 to 5, it can be seen that under the conditions of the same 4-butylresorcinol and cosolvent content, there is a certain synergistic effect between sodium pyrosulfite, sodium bisulfite, ergothioneine and troxerutin.

[0076] By comparing Example 1 with Comparative Examples 6 to 11, it can be seen that even if 4-butylresorcinol, sodium pyrosulfite, sodium bisulfite, ergothioneine and troxerutin are composited, if the dosage of any one of sodium pyrosulfite, sodium bisulfite, ergothioneine and troxerutin is inappropriate, it is difficult to make 4-butylresorcinol have better color stability.

[0077] By comparing Example 1 with Comparative Examples 12 to 15, it can be seen that by replacing any one of sodium pyrosulfite, sodium bisulfite, ergothioneine and troxerutin with other antioxidants, it is also difficult to ensure that 4-butylresorcinol has better color stability.

[0078] Test Example 2 The color stability test was performed on the facial creams provided in Application Examples 1 to 20.

[0079] Test conditions: UV light and LED light were used simultaneously in a Binder KBF720 LQC constant temperature and humidity chamber system. The UV light had an illumination of 0.9 W·hr / m per hour. 2 The LED lamp had an illumination of 7000LUX·hr per hour and was subjected to a stability test for 3 months (90 days) under non-dark conditions.

[0080] Test instrument: Color data was measured using KONICA MINOLTA equipment (CM-26d).

[0081] Test method: Each composition sample is contained in a plurality of sample bottles and loaded into the CM-26d measurement port, and the values ​​at different storage stages are tested. According to the measurement procedures specified in the relevant instrument menu and computer software, the color (a*, b* and L*) is measured and calculated to generate color change data (ΔE) values. For reference, a ΔE value of about 3 is the threshold value of the original sample color change that can be detected by people's sight.

[0082] The test results are shown in Table 3. Generally speaking, a ΔE value ≤ 3 is acceptable, a ΔE value between 3.5 and 5 is negotiable, and a ΔE value > 5 is unacceptable.

[0083] The test results are shown in Table 3 and Figures 1 to 4 shown.

[0084] Table 3 Test results

[0085] As can be seen from Table 2, the facial creams prepared from the compositions provided in Examples 1 to 5 of the present invention have significantly greater color stability than the facial creams prepared from the compositions provided in Comparative Examples 2 to 15.

[0086] Among Application Examples 1 to 5, Application Example 1 has the best effect.

[0087] In summary, the composition provided by the present invention can keep 4-butylresorcinol from changing color for a long time, especially under the conditions of ultraviolet irradiation and light irradiation for 3 months, and can still maintain the original color. The composition is used to prepare an external skin preparation, which can make the external skin preparation also have better color stability and improve the product quality of the external skin preparation.

[0088] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A composition for improving the stability of 4-butylresorcinol, characterized in that: In parts by weight, the composition comprises 0.01 to 5 parts of 4-butylresorcinol, 0.005 to 0.195 parts of sodium pyrosulfite, 0.005 to 0.195 parts of sodium bisulfite, 0.005 to 3 parts of ergothioneine and 0.003 to 0.2 parts of troxerutin.

2. Use of the composition according to claim 1 in preparing an external skin preparation.

3. A skin preparation for external use, characterized in that: The raw materials for preparing the external skin preparation include the composition according to claim 1.

4. The external skin preparation according to claim 3, characterized in that The external skin preparations include cosmetics.

5. The external skin preparation according to claim 4, characterized in that Calculated by mass percentage, the cosmetic contains 0.01% to 5% of 4-butylresorcinol, 0.005% to 0.195% of sodium metabisulfite, 0.005% to 0.195% of sodium bisulfite, 0.005% to 3% of ergothioneine and 0.003% to 0.2% of troxerutin.

6. The external skin preparation according to claim 5, characterized in that The cosmetic is a facial cream, and the raw materials for preparing the facial cream also include auxiliary materials; the auxiliary materials include at least one of a preservative, a thickener, a moisturizer, an emulsifier, a moisturizer and a skin conditioner.

7. The external skin preparation according to claim 6, characterized in that In percentage by mass, the content of preservatives in the raw materials for preparing the facial cream is 0.05%~7%; and / or, the content of thickeners in the raw materials for preparing the facial cream is 0.05%~2%; and / or, the content of moisturizers in the raw materials for preparing the facial cream is 1%~15%; and / or, the content of emulsifiers in the raw materials for preparing the facial cream is 0.5%~6.5%; and / or, the content of emollients in the raw materials for preparing the facial cream is 1%~10%; and / or, the content of skin conditioners in the raw materials for preparing the facial cream is 0.1%~5%.

8. The external skin preparation according to claim 6 or 7, characterized in that The preservative comprises at least one of pentylene glycol, 1,2-hexanediol, p-hydroxyacetophenone, caprylyl glycol, ethylhexylglycerin, chlorphenesin and phenoxyethanol; And / or, the thickener includes at least one of carbomer, xanthan gum, cellulose, acrylic acid (esters) / C10-30 alkyl acrylate cross-linked polymer, ammonium acryloyldimethyl taurate / VP copolymer, sodium acrylate / sodium acryloyldimethyl taurate and hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer; And / or, the moisturizing agent includes at least one of glycerin, butylene glycol, 1,3-propylene glycol, dipropylene glycol, xylitol and glyceryl polyether-26; and / or, the emulsifier comprises at least one of sodium stearoyl lactylate, higher alcohols, glyceryl stearate, sorbitan laurate and glyceryl oleate citrate; and / or, the emollient comprises at least one of dimethicone, butylene glycol dicaprylate / dicaprate, isononyl isononanoate, squalane and caprylic / capric triglyceride; And / or, the skin conditioning agent includes at least one of panthenol, ectoine, bisabolol, niacinamide, rape sterols and yeast fermentation extract.

9. The external skin preparation according to claim 8, characterized in that Calculated by mass percentage, the raw materials for preparing the facial cream include 0.01% to 5% of 4-butylresorcinol, 0.005% to 0.195% of sodium pyrosulfite, 0.005% to 0.195% of sodium bisulfite, 0.005% to 3% of ergothioneine, 0.003% to 0.2% of troxerutin, 7% to 8% of butanediol, 0.08% to 0.12% of xanthan gum, and 0.45% to 0.55% of acryloyl Ammonium dimethyltaurate / VP copolymer, 4.5%~5.5% pentylene glycol, 0.45%~0.55% 1,2-hexanediol, 1.9%~2.0% glyceryl stearate, 0.25%~0.35% sodium stearoyl lactylate, 3.5%~4.0% cetearyl alcohol, 5.5%~6.5% butylene glycol dicaprylate / dicaprate and 2.5%~3.5% polydimethylsiloxane, the balance is solvent.

10. The external skin preparation according to claim 9, characterized in that The preparation method of the facial cream comprises: According to the proportion, the glyceryl stearate, the sodium stearoyl lactylate, the cetearyl alcohol, the butylene glycol dicaprylate / dicaprate and the polydimethylsiloxane are mixed at 80° C. to 90° C. for 8 min to 15 min to obtain phase A; According to the ratio, the xanthan gum, the ammonium acryloyldimethyltaurate / VP copolymer and the butanediol are mixed, and then the pentanediol, the 1,2-hexanediol and water are added, and the mixture is mixed at 85° C. to 95° C. for 25 min to 35 min to obtain phase B; Add the phase A to the phase B and homogenize at 6500 r / min-7500 r / min for 4-6 min; After cooling to 35° C. to 40° C., the composition consisting of 4-butylresorcinol, sodium pyrosulfite, sodium bisulfite, ergothioneine and troxerutin is added and stirred evenly.

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