Composition with oil control effect

Abstract

The invention relates to a composition with an oil control effect. The composition comprises the following components in parts by mass: 50-70 parts of rosemary leaf water; 1-5 parts of a rosemary leaf extract; 1-5 parts of rosemary leaf oil; 0.2-5 parts of an artemisia annua extract; 0.2-5 parts of a sophora flavescens extract; 0.2-5 parts of a mangnolia officinalis extract; and 0.2-5 parts of a pseudo-ginseng extract. The rosmarinus officinalis extract is prepared by grinding or impregnating top tender shoots of a rosmarinus officinalis plant in a solvent. The rosemary leaf water is prepared by carrying out microwave treatment on top tender shoots of rosemary plants soaked in deionized water. The rosemary leaf oil is prepared by performing carbon dioxide supercritical extraction on top tender shoots of rosemary plants.

Description

Technical Field

[0001] The invention relates to the field of daily chemicals, and in particular to a composition with oil-controlling effect. Background Art

[0002] This section provides background information related to the present application which does not necessarily constitute prior art.

[0003] Excessive oil secretion from the scalp is the main cause of greasy hair. People with oily scalps are more likely to have greasy hair because the excessive oil secretion from the scalp can easily breed bacteria, affect the normal metabolism of hair, and even cause hair loss. Studies have found that excessive oil secretion from the scalp may be related to the excessive activity of type I 5α reductase in the sebaceous glands of the scalp skin. 5-α reductase is a membrane protease that depends on reduced coenzyme II. It can catalyze the conversion of testosterone (T) into dihydrotestosterone (DHT). T and DHT act on the same androgen receptor, but DHT has stronger catalytic activity and stronger affinity for androgen receptors, so the catalytic conversion of 5α reductase can amplify the androgen response. T and DHT act on hormone receptors in sebaceous gland cells, which can promote the proliferation of human sebaceous gland cells in a dose-dependent manner, increase the volume of sebaceous glands, and secrete excessive sebum.

[0004] Existing shampoo products with oil-control effects mainly rely on ingredients such as salicylic acid and selenium disulfide to achieve the purpose of oil control. However, the amount of these ingredients required when used alone is relatively large. If used for a long time, it will damage the scalp microecology and scalp barrier, leading to problems such as itchy scalp and easy oil return.

[0005] After research, we use a combination of multiple ingredients, combined with the pathway mechanism of instant oil control and long-term oil control, and adopt a composite ratio process of natural plant ingredients and synthetic ingredients. While solving the problem of hair and scalp oil control, we try to be gentle and not damage the hair and scalp. Summary of the invention

[0006] The present invention aims to provide a composition with excellent oil control effect and mild without damaging hair and scalp. The composition is mild and non-irritating. The components of the composition can synergistically inhibit 5α-reductase activity, improve the oil-water balance of the scalp, and achieve long-term oil control to avoid excessive oil secretion of the scalp.

[0007] To achieve the above object, the present invention adopts the following technical solution: a composition with oil control effect, comprising the following components in parts by weight:

[0008] 50-70 parts of rosemary leaf water;

[0009] 1-5 parts of rosemary leaf extract;

[0010] 1-5 parts of rosemary leaf oil;

[0011] 0.2-5 parts of Artemisia annua extract;

[0012] 0.2-5 parts of Sophora flavescens extract;

[0013] 0.2-5 parts of Magnolia officinalis extract;

[0014] 0.2-5 parts of Panax notoginseng extract.

[0015] It should be noted that the rosemary extract, rosemary leaf water and rosemary leaf oil are all prepared using the top tender shoots of rosemary plants as raw materials, and fresh top tender shoots of rosemary plants are preferred.

[0016] The rosemary extract can be obtained using conventional methods, including but not limited to grinding, maceration, pressing, squeezing, mashing, centrifugation and / or processes such as cold percolation, stirring / distillation, microwave-assisted extraction, ultrasonic treatment, supercritical / subcritical CO2 compressed gas extraction with or without polar modifiers, pressurized solvent extraction, accelerated solvent extraction, surfactant-assisted pressurized hot water extraction, oil extraction, membrane extraction, etc., or directly extracted from biomass by other methods such as solvent extraction, the solvent is usually an organic solvent such as alcohol, acetone, liquid carbon dioxide with or without polar modifiers, hexane or chloroform.

[0017] Preferably, the rosemary extract is prepared by grinding or impregnating plant biomass (i.e., the top tender shoots of the rosemary plant) in a solvent, and the rosemary extract mainly comprises non-polar compounds, and the plant biomass can be completely separated from the extract and is not used after extraction. The solvent comprises a polar solvent, a non-polar solvent, or a combination of two or more thereof. The polar solvent comprises a polar inorganic solvent (such as water, etc.) and a polar organic solvent, and the polar organic solvent can be selected from alcohols and corresponding organic acids, for example, C1-C8 alcohols including methanol, ethanol, propanol, butanol, etc., organic acids including acetic acid, formic acid, propionic acid, etc., polyols and glycols including C1-C8 polyols / glycols, etc., and combinations of two or more thereof. The non-polar solvent includes a non-polar organic solvent, such as alkanes (including C1-C8 alkanes), cycloalkanes (including C1-C8 alkanes), alkyl ethers (including C1-C8 alkyl ethers), petroleum ethers, ketones (including C1-C8 ketones), dichloromethane, ethyl acetate, xylene, toluene, chloroform, vegetable oil, mineral oil, etc. Preferably, the solvent is ethanol and butanediol.

[0018] In one or more embodiments, the preparation method of the rosemary extract comprises the following steps:

[0019] Step 1, the top tender shoots of the rosemary plant are crushed, and then immersed in a mixed solution prepared by ethanol and butanediol in a volume ratio of 1-4:1 and left to stand for not less than 24 hours, the mass volume ratio of the top tender shoots of the rosemary plant to the mixed solution is 1g: (30-60mL), and then the extraction solution is collected by filtering;

[0020] Step 2: Concentrating and drying the extract solution under reduced pressure in sequence to obtain the rosemary extract.

[0021] The rosemary leaf water is prepared by microwave assisted extraction (MAE) technology, more specifically, by subjecting plant biomass (i.e., the top tender shoots of rosemary plants) soaked in deionized water to microwave treatment.

[0022] In one or more embodiments, the preparation method of rosemary leaf water comprises the following steps: crushing the top tender shoots of the rosemary plant, then mixing them with deionized water at a mass volume ratio of 1g:(80-100mL), and then placing them in a microwave reactor for microwave treatment, setting the microwave power to 400-600W and the microwave time to 15-20min. After completion, filtering to obtain the filtrate, which is the rosemary leaf water.

[0023] The rosemary leaf oil is prepared by supercritical carbon dioxide extraction technology, and more specifically, is prepared by supercritical carbon dioxide extraction of plant biomass (i.e. the top tender shoots of rosemary plants).

[0024] In one or more embodiments, the preparation method of rosemary leaf oil comprises the following steps:

[0025] Step 1, crushing the top tender shoots of the rosemary plant, and then mixing them with an aqueous alcohol solution (i.e., a mixture of alcohol in water) at a mass volume ratio of 1g: (40-60mL), standing for not less than 12 hours, and filtering to obtain a filter residue, wherein the aqueous alcohol solution contains alcohol with a volume percentage concentration of about 5% to 10%, and suitable examples of alcohols include C1-C8 alcohols, C1-C8 polyols / diols, and combinations of two or more thereof, and preferred alcohols include methanol, ethanol, or combinations thereof;

[0026] Step 2, washing and drying the filter residue and then putting it into an extraction kettle of supercritical carbon dioxide extraction, extracting under a supercritical CO2 atmosphere to obtain an extract, the extraction temperature is 35-40°C, the extraction pressure is 15-25MPa, the CO2 flow rate is 10-20L / h, and the extraction time is 2-3 hours;

[0027] Step three, distilling and separating the extract obtained in step two under vacuum conditions to obtain the rosemary leaf oil, the vacuum degree is 0.05-0.1 MPa, and the distillation temperature is 40-60°C.

[0028] Among them, rosemary leaf water is rich in water-soluble rosmarinic acid, tannic acid and other organic acids, which have the effects of oil control, antipruritic, and anti-oxidation; rosemary leaf extract has the effect of anti-inflammatory and inhibiting the growth of microorganisms in hair follicles; rosemary leaf oil is the oil-soluble component of rosemary, and the 1,8-cineole and verbenanes contained in it are skin penetrants, which help soften skin keratin, balance oil secretion, and dredge and tighten pores.

[0029] Among them, Artemisia annua extract, also known as Artemisia annua extract, was tested by the human sebaceous gland intracellular lipid content determination method and found that Artemisia annua extract has obvious oil control effect, and was tested by the hyaluronidase inhibition rate method and found that Artemisia annua extract has obvious soothing effect.

[0030] Among them, Sophora flavescens extract and Magnolia officinalis extract both have antibacterial effects.

[0031] Among them, Panax notoginseng, as a traditional medicinal material for promoting blood circulation and removing blood stasis, its extract can effectively promote blood circulation in the scalp and improve the efficiency of oil-control ingredients.

[0032] In one or more embodiments, the composition further comprises a pharmaceutically and / or cosmetically acceptable carrier. Any suitable carrier may be used in the composition. In one or more embodiments, the carrier is a cosmetically acceptable carrier. The carrier may exist in a wide variety of forms, and examples of suitable cosmetically acceptable carriers include cosmetically acceptable solvents and materials suitable for cosmetic solutions, suspensions, lotions, creams, essences, essences, gels, toners, sticks, sprays, ointments, lotions and soap bars, shampoos, conditioners, pastes, foams, mousses, powders, shaving creams, wipes, patches, bands, super patches, microneedle patches, bandages, hydrogels, film-forming products, facial masks and skin patches, foundations, droplets, etc. These product types may include several types of cosmetically acceptable carriers, including but not limited to solutions, suspensions, emulsions such as microemulsions and nanoemulsions, gels, solids, liposomes, other encapsulation technologies, and the like. In one or more embodiments, the carrier is water. In one or more embodiments, the carrier comprises one or more aqueous or organic solvents, examples of organic solvents include, but are not limited to, dimethyl isosorbide; isopropyl myristate, cationic, anionic and nonionic surfactants; vegetable oils; mineral oils; waxes; gums; synthetic and natural gelling agents; alkanols; glycols; and polyols. Examples of glycols include, but are not limited to, glycerol, propylene glycol, butylene glycol, pentanediol, hexanediol, polyethylene glycol, polypropylene glycol, diethylene glycol, triethylene glycol, octanediol, glycerol, butylene glycol and hexanetriol and copolymers or mixtures thereof. Examples of alkanols include, but are not limited to, alkanols having from about 2 carbon atoms to about 12 carbon atoms (e.g., from about 2 carbon atoms to about 4 carbon atoms), such as isopropanol and ethanol. Examples of polyols include, but are not limited to, polyols having from about 2 carbon atoms to about 15 carbon atoms (e.g., from about 2 carbon atoms to about 10 carbon atoms), such as propylene glycol.

[0033] Without affecting the technical effect of the composition, the composition of the present invention may also include any of a variety of other cosmetic active agents. Examples of suitable additional active agents include: preservatives, conditioning agents, skin lightening agents, dark color agents, anti-aging agents, elastin promoters, collagen promoters, anti-acne agents, oil control agents, antimicrobial agents, anti-inflammatory agents, antiparasitic agents, topical analgesics, sunscreens, light protection agents, antioxidants, keratolytic agents, surfactants, moisturizers, nutrients, vitamins, energy enhancers, antiperspirants, astringents, deodorants, depilatories, hair growth enhancers, hair growth retardants, curing agents, hydrating agents, synergists, anti-hardening agents, skin conditioning agents, anti-cellulitis agents, odor control agents such as odor masking agents or pH regulators, etc. For example, preservatives are selected from salicylic acid and / or OCT (Octolamine), and conditioning agents are selected from capryloyl glycine and / or arginine.

[0034] In one or more embodiments, the composition is in the form of a solution, suspension, emulsion, lotion, cream, serum, gel, stick, spray, ointment, liquid wash, soap bar, shampoo, conditioner, paste, foam, powder, mousse, shaving cream, hydrogel, or a film-forming product.

[0035] Another aspect of the present invention relates to the use of the composition for scalp and scalp oil control, the use comprising: applying an effective dose of the composition to the hair and scalp of a user in need thereof.

[0036] In one or more embodiments, a shampoo containing the composition is applied to the user's hair and scalp to achieve a long-lasting oil control effect, and the composition is present in the shampoo at a combined concentration of about 0.1 wt % to about 20 wt % by weight of the shampoo.

[0037] Another aspect of the present invention relates to a method for preparing the composition, comprising the steps of:

[0038] Step 1, pre-mixing rosemary leaf water and rosemary leaf extract in a mixing container;

[0039] Step 2: Add rosemary leaf oil, artemisia annua extract, sophora flavescens extract, magnolia bark extract and Panax notoginseng extract into a mixing container, mix them homogeneously and then discharge them to obtain the composition. It is unexpectedly found that rosemary leaf oil can act as a solubilizer.

[0040] The composition provided by the present invention reduces the intracellular lipid content by inhibiting 5-α reductase, and instantly controls oil; it regulates the secretion of sebaceous glands, tightens pores, reduces the long-term secretion of oil, and controls oil for a long time. The composition provided by the present invention inhibits the reproduction of unhealthy bacteria, improves the scalp microecology, reduces irritating allergens, and reduces stimulation to the sebaceous glands of the scalp, thereby achieving long-term maintenance of the oil control effect. The composition provided by the present invention can maintain the long-term health of the scalp and hair through the synergistic effect between the components.

[0041] Surprisingly, it was found that the composition provides unexpectedly good antibacterial properties and good oil control effects. When combined, the composition exhibits synergistic antibacterial and oil control effects, and the antibacterial and / or oil control effects of the composition show a strong weakening trend when any component is missing.

[0042] It should be noted that, in addition to being applied to solvent-based or emulsion-based products such as shampoo or conditioner, the composition provided by the present invention can also be applied to gels (e.g., aqueous gels, alcohol gels or alcohol / hydrogels) to give the gels oil control, pore tightening and anti-inflammatory effects, and the composition can also be applied to solid preparations (e.g., wax-based sticks, soap bar compositions, powders or wipes), and the composition can also be combined with solid, semi-solid or soluble substrates (e.g., wipes, masks, pads, gloves or belts). DETAILED DESCRIPTION

[0043] It should be understood that the specific embodiments described herein are only used to explain the present invention, and are not used to limit the present invention.

[0044] In the embodiments of the present invention, Artemisia annua extract (CAS No.: 84775-74-6), Sophora flavescens extract (CAS No.: 57126-62-2), Magnolia officinalis extract (CAS No.: 528-43-8), Panax notoginseng extract (CAS No.: 80418-29-7), rosmarinic acid (CAS No.: 80225-53-2), rosemary essential oil (CAS No.: 8000-25-7), capryloyl glycine and salicylic acid are all commercially available products.

[0045] In an embodiment of the present invention, the preparation method of rosemary extract comprises the following steps:

[0046] Step 1, the top tender shoots of the rosemary plant are crushed, and then immersed in a mixed solution prepared by ethanol and butanediol in a volume ratio of 2:1 and left to stand for 24 hours, the mass volume ratio of the top tender shoots of the rosemary plant to the mixed solution is 1g:50mL, and then the extraction solution is collected by filtration;

[0047] Step 2: Concentrating and drying the extract solution under reduced pressure in sequence to obtain the rosemary extract.

[0048] In an embodiment of the present invention, the preparation method of rosemary leaf water comprises the following steps: crushing the top tender shoots of the rosemary plant, then mixing with deionized water at a mass volume ratio of 1g:90mL, and then placing in a microwave reactor for microwave treatment, setting the microwave power to 500W and the microwave time to 18min. After completion, filtering to obtain a filtrate, which is the rosemary leaf water.

[0049] In an embodiment of the present invention, the preparation method of rosemary leaf oil comprises the following steps:

[0050] Step 1, crushing the top tender shoots of the rosemary plant, and then mixing them with an aqueous alcohol solution (i.e., a mixture of alcohol in water) at a mass volume ratio of 1g:50mL, standing for 12 hours, and filtering to obtain a filter residue, wherein the aqueous alcohol solution contains ethanol with a volume percentage concentration of about 8%;

[0051] Step 2, washing and drying the filter residue and then putting it into an extraction kettle of supercritical carbon dioxide extraction, extracting under a supercritical CO2 atmosphere to obtain an extract, the extraction temperature is 38°C, the extraction pressure is 20MPa, the CO2 flow rate is 15L / h, and the extraction time is 2.5 hours;

[0052] Step three, distilling and separating the extract obtained in step two under vacuum conditions to obtain the rosemary leaf oil, the vacuum degree is 0.08 MPa, and the distillation temperature is 50°C.

[0053] [Examples 1-3]

[0054] The specific composition ratios of the compositions provided in Examples 1-3 are shown in Table 1.

[0055] The preparation methods of the compositions provided in Examples 1-3 all include the following steps:

[0056] Step 1, pre-mixing rosemary leaf water and rosemary leaf extract in a mixing container;

[0057] Step 2: adding rosemary leaf oil, artemisia annua extract, sophora flavescens extract, magnolia bark extract and Panax notoginseng extract into a mixing container, mixing them homogeneously and discharging the mixture to obtain the composition.

[0058] [Comparative Examples 1-6]

[0059] The specific composition ratios of the compositions provided in Comparative Examples 1-6 are shown in Table 2. Among them, capryloyl glycine can be used in shampoo, and adding 0.1wt% of capryloyl glycine in shampoo can effectively inhibit 5-α reductase to achieve a good oil control effect. Salicylic acid can be used in skin care products. Salicylic acid can penetrate into the pores to regulate oil secretion, control oiliness, and has a good antibacterial effect.

[0060] Table 1

[0061] Components Example 1 Example 2 Example 3 Rosemary Leaf Water 50 70 60 Rosemary Leaf Extract 1 5 4 Rosemary Leaf Oil 1 5 4 Artemisia annua extract 0.2 5 3 Sophora flavescens extract 0.2 5 3 Magnolia Bark Extract 0.2 5 3 Panax Notoginseng Extract 0.2 5 3

[0062] Table 2

[0063] Components Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Rosemary Leaf Water / 60 60 60 60 60 Deionized water 60 / / / / / Rosemary Leaf Extract 4 / 4 4 4 4 Rosmarinic acid / 4 / / / / Rosemary Leaf Oil 4 4 / 4 4 4 Rosemary essential oil / / 4 / / / Artemisia annua extract 3 3 3 / 3 3 Capryloyl Glycine / / / 3 / 3 Sophora flavescens extract 3 3 3 3 / 3 Magnolia Bark Extract 3 3 3 3 / 3 Salicylic acid / / / / 6 / Panax Notoginseng Extract 3 3 3 3 3 /

[0064] [Comparative test]

[0065] The compositions provided in Examples 1-3 and the compositions provided in Comparative Examples 1-6 were tested as follows:

[0066] 1.5α-reductase inhibition test

[0067] 5α-reductase can convert testosterone into DHT with the participation of reduced coenzyme II (NADPH), thereby stimulating the sebaceous glands to secrete sebum. According to UV-visible spectrophotometry, NADPH has a characteristic absorption peak at 340nm, while the characteristic absorption peak of the product after participating in the reaction disappears at 340nm. The inhibition of 5α-reductase activity by each composition is determined by measuring the absorbance of the solution. The specific experimental method is as follows:

[0068] Step 1: add 60 μL of phosphate buffer with a pH of 7.4, 6 μL of 5α-reductase, 4 μL of testosterone, and 30 μL of NADPH to the test tube in sequence, mix well and measure the absorbance, incubate at 37°C for 60 minutes and measure the absorbance again to calculate the blank control NADPH absorbance decrease value A0;

[0069] Step 2: Add 55 μL of phosphate buffer with a pH of 7.4, 6 μL of 5α-reductase, 4 μL of testosterone, 30 μL of NADPH, and 5 μL of the composition to be tested to the test tube in sequence, mix well and measure the absorbance, incubate at 37°C for 60 minutes and measure the absorbance again to calculate the decrease value A1 of NADPH absorbance in the experimental group.

[0070] The calculation formula of 5α-reductase inhibition rate is as follows:

[0071] 5α-reductase inhibition rate = [(A0-A1) / A0] × 100%, the inhibition rates of 5α-reductase corresponding to the compositions provided in Examples 1-3 and the inhibition rates of 5α-reductase corresponding to the compositions provided in Comparative Examples 1-6 are shown in Table 3. As can be seen from Table 3, the compositions provided in the present application can significantly inhibit the activity of 5α-reductase, and there is a synergistic effect between the components of the compositions provided in the present application.

[0072] 2. Oil control effect test:

[0073] The compositions provided in Examples 1-3 and the compositions provided in Comparative Examples 1-6 were respectively used to prepare shampoos for the experimental group.

[0074] The shampoo of the experimental group includes the following components by weight:

[0075] 70 parts by mass of deionized water;

[0076] 5 parts by mass of sodium laureth sulfate;

[0077] 5 parts by mass of cocamidopropyl betaine;

[0078] 2 parts by mass of disodium cocoyl glutamate;

[0079] 2 parts by mass of sodium lauryl sulfate;

[0080] 2 parts by mass of cocamide DEA;

[0081] 2 parts by mass of polydimethylsiloxane;

[0082] 1 part by mass of dimethicone;

[0083] 1 part by mass of cyclomethicone

[0084] 10 parts by mass of the composition to be tested.

[0085] The preparation method of the shampoo of the experimental group comprises the following steps:

[0086] Step 1: Add deionized water, sodium laureth sulfate, cocamidopropyl betaine, and disodium cocoyl glutamate into a stirring pot in sequence, heat to 85° C. and stir for 3 minutes to completely dissolve, and continue stirring to cool down;

[0087] Step 2: When the mixture in the stirring pot is cooled to 60°C, sodium lauryl sulfate, polydimethylsiloxane, cocamide DEA, and cyclomethicone are added in sequence and stirred until the mixture is evenly emulsified;

[0088] Step 3, when the mixture in the stirring pot is cooled to 45° C., polydimethylsiloxane alcohol and the composition to be tested are added in sequence, stirred evenly, and continued to be stirred until the mixture is cooled to room temperature, and the shampoo is obtained by discharging the mixture.

[0089] The difference between the shampoo in the control group and the shampoo in the experimental group is only that: the shampoo in the control group does not contain the composition to be tested, and the shampoo in the control group contains 80 parts by mass of deionized water.

[0090] The specific experimental method for the oil control effect of shampoo is as follows:

[0091] Step 1, 100 subjects with oily scalp were selected and randomly divided into ten groups, with 10 subjects in each group, nine of which used shampoos of the experimental group corresponding to different compositions, and the remaining group used shampoos of the control group;

[0092] Step 2. After the subjects have been in the experimental environment (ambient temperature of 20-25°C, ambient humidity of 40% RH-60% RH) for 36 hours, the subjects use shampoo to fully clean their hair and head skin, and use the scalp oil tester MeibometerMB560 (based on the principle of oil testing photometer) to test the scalp oil values ​​of the subjects before using shampoo, 0 hours after using shampoo, 8 hours after using shampoo, and 24 hours after using shampoo. The results are averaged, and the oil control effect is evaluated by the scalp oil values ​​at different times.

[0093] The results of the oil control effect test are shown in Table 3. As can be seen from Table 3, the composition provided by the present application has an excellent oil control effect, and the oil control effect lasts for a long time, and there is a synergistic effect between the components of the composition provided by the present application.

[0094] Table 3

[0095]

[0096] 3. Antibacterial effect test

[0097] The specific experimental methods are as follows:

[0098] Step 1, preparing a sample by mixing the composition to be tested and deionized water in a mass ratio of 1:9;

[0099] Step 2: Escherichia coli, Staphylococcus aureus, Propionibacterium acnes, and Candida albicans are inoculated on a nutrient medium, activated at 37°C for 12 hours, and then made into 5 ml / L bacterial suspensions with sterile water, and placed in a refrigerator at 4°C for standby use.

[0100] Step three, using the filter paper diffusion method, the filter paper was made into small round pieces of 6 mm paper, and the small round filter paper was attached to the nutrient culture medium coated with 5 mL / L of bacterial suspension, 5 μL of the prepared sample was taken and dropped on each filter paper, and sterile water was used as a control. Then, it was placed in a 37 ° C constant temperature incubator and cultured for 24 hours. The bacterial growth was observed and the diameter of the inhibition zone was measured. The antibacterial effect was evaluated by the diameter of the inhibition zone.

[0101] The results of the antibacterial effect test are shown in Table 4. As can be seen from Table 4, the diameter of the antibacterial circle of the composition provided by the present application is the largest and the antibacterial effect is the best, indicating that the components of the composition provided by the present application have a synergistic effect.

[0102] Table 4

[0103]

[0104] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0105] The above-mentioned embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A composition having an oil control effect, characterized in that: The composition comprises the following components in parts by weight: 50-70 parts of rosemary leaf water; 1-5 parts of rosemary leaf extract; 1-5 parts of rosemary leaf oil; 0.2-5 parts of Artemisia annua extract; 0.2-5 parts of Sophora flavescens extract; 0.2-5 parts of Magnolia officinalis extract; 0.2-5 parts of Panax notoginseng extract; The rosemary extract is prepared by grinding or macerating the top young shoots of the rosemary plant in a solvent, wherein the solvent comprises a polar solvent, a non-polar solvent or a combination of two or more thereof; the rosemary leaf water is prepared by subjecting the top young shoots of the rosemary plant soaked in deionized water to microwave treatment; The rosemary leaf oil is prepared by subjecting the top tender shoots of the rosemary plant to supercritical carbon dioxide extraction.

2. The composition according to claim 1, characterized in that The preparation method of the rosemary extract comprises the following steps: Step 1, the top tender shoots of the rosemary plant are crushed, and then immersed in a mixed solution prepared by ethanol and butanediol in a volume ratio of 1-4:1 and left to stand for not less than 24 hours, the mass volume ratio of the top tender shoots of the rosemary plant to the mixed solution is 1g: (30-60mL), and then the extraction solution is collected by filtering; Step 2: Concentrating and drying the extract solution under reduced pressure in sequence to obtain the rosemary extract.

3. The composition according to claim 1, characterized in that The preparation method of the rosemary leaf water comprises the following steps: crushing the top tender buds of the rosemary plant, mixing them with deionized water at a mass volume ratio of 1g:(80-100mL), placing them in a microwave reactor for microwave treatment, setting the microwave power to 400-600W and the microwave time to 15-20min, and after completion, filtering to obtain a filtrate, which is the rosemary leaf water.

4. The composition according to claim 1, characterized in that The preparation method of the rosemary leaf oil comprises the following steps: Step 1, crushing the top tender shoots of the rosemary plant, and then mixing them with an aqueous alcohol solution (i.e., a mixture of alcohol in water) at a mass volume ratio of 1g: (40-60mL), leaving it to stand for not less than 12 hours, and filtering to obtain a filter residue, wherein the aqueous alcohol solution contains an alcohol with a volume percentage concentration of about 5% to 10%, and the alcohol includes a C1-C8 alcohol, a C1-C8 polyol / diol, and a combination of two or more thereof; Step 2, washing and drying the filter residue and then putting it into an extraction kettle of supercritical carbon dioxide extraction, extracting under a supercritical CO2 atmosphere to obtain an extract, the extraction temperature is 35-40°C, the extraction pressure is 15-25MPa, the CO2 flow rate is 10-20L / h, and the extraction time is 2-3 hours; Step three, distilling and separating the extract obtained in step two under vacuum conditions to obtain the rosemary leaf oil, the vacuum degree is 0.05-0.1 MPa, and the distillation temperature is 40-60°C.

5. The composition according to claim 1, characterized in that The composition also includes preservatives and conditioning agents.

6. The composition according to claim 5, characterized in that The preservative is salicylic acid and / or pyroximate ethanolamine salt.

7. The composition according to claim 5, characterized in that The conditioning agent is capryloyl glycine and / or arginine.

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