Compound soft capsule for easing pain and preparation method thereof

Abstract

The invention discloses a compound soft capsule for easing pain and a preparation method thereof, and belongs to the technical field of health food. The soft capsule is prepared from the following medicinal materials in parts by weight: 120 to 140 parts of radix angelicae, 80 to 100 parts of fructus evodiae, 80 to 100 parts of liquorice root, 60 to 75 parts of cortex cinnamomi, 40 to 60 parts of fructus piperis longi, 50 to 70 parts of fructus foeniculi, 40 to 60 parts of semen brassicae junceae, 20 to 30 parts of pericarpium zanthoxyli and 20 to 30 parts of black pepper. The compound analgesic capsule disclosed by the invention is prepared by selecting medicines based on the principle of'pain due to obstruction 'in traditional Chinese medicine, and adopts traditional Chinese medicines for promoting qi circulation and relieving pain, so that qi movement in a body is smooth, blood is circulated, and various diseases and pains are relieved. According to the invention, the decoction liquid medicine is prepared firstly, then the liquid medicine is concentrated, then the intermediate liquid medicine is mixed with the medicine powder to prepare the ointment powder, then the concentrated liquid medicine is mixed with the ointment powder to prepare the final medicine powder, the medicine performance is changed through multiple steps, and finally the concentrated liquid medicine and the ointment powder are mixed, so that the prepared fine powder can exert the medicine effect to the maximum extent.

Description

Technical Field

[0001] The invention belongs to the technical field of health food, and particularly relates to a compound soft capsule for analgesia and a preparation method thereof. Background Art

[0002] As the pace of modern life accelerates, unhealthy eating habits or a decline in physical fitness can cause diseases such as gastritis and dysmenorrhea, but Western medicine has obvious side effects and is not suitable for long-term use. Modern people generally choose to take Chinese medicine to regulate their bodies, but the complete medicinal materials are also toxic and are not suitable for long-term use. In addition, Chinese medicine needs to be boiled in water and taken, which is not convenient.

[0003] Medicine and food are of the same origin, which is one of the important contents in the treasure house of Chinese medicine, and also one of the original advantages of traditional Chinese medicine. Medicine and food are of the same origin, which means that many foods are medicines, and there is no absolute dividing line between them. In life, some medicines can only be used to treat diseases, so they are called medicines, and some foods can only be eaten as diet, so they are called food, but some foods can be used as diet and have certain therapeutic effects, so they are called medicine and food. In traditional Chinese medicine, medicine and food are of the same origin, and medicine and food complement and use each other. There is no strict boundary between medicine and food. Combining the two to maintain health and treat diseases is a significant feature of traditional Chinese medicine treatment. Therefore, there is food in medicine treatment and medicine in diet treatment. At present, most of the compound soft capsules used for analgesia are Western medicines. Even if there are a few analgesic compound capsules based on the principle of traditional Chinese medicine, they are prepared based on complete traditional Chinese medicine, so there is a lack of capsules with high efficacy based on medicinal materials with medicine and food as the basic raw materials. Summary of the invention

[0004] In view of this, the object of the present invention is to provide a compound soft capsule for analgesia and a preparation method to solve the above problems.

[0005] In order to achieve the above object, the present invention provides the following technical solutions:

[0006] The invention provides a compound soft capsule for relieving pain. The medicinal materials in the soft capsule are 120-140 parts by weight of angelica dahurica, 80-100 parts of evodia rutaecarpa, 80-100 parts of liquorice, 60-75 parts of cinnamon bark, 40-60 parts of piperita lancea, 50-70 parts of fennel, 40-60 parts of yellow mustard seeds, 20-30 parts of prickly ash and 20-30 parts of black pepper.

[0007] Furthermore, the medicinal materials in the soft capsule are 130 parts of angelica dahurica, 90 parts of evodia rutaecarpa, 90 parts of liquorice, 68 parts of cinnamon, 50 parts of piperita lancea, 60 parts of cumin, 50 parts of yellow mustard seeds, 25 parts of Zanthoxylum bungeanum, and 25 parts of black pepper.

[0008] Furthermore, it also includes a method for preparing a compound soft capsule for analgesia, comprising the following steps:

[0009] S1. Remove impurities from angelica dahurica, evodia rutaecarpa, cinnamon bark, piper longifolia, cumin, yellow mustard, prickly ash, black pepper and liquorice, wash and dry them in the sun;

[0010] S2, the medicinal materials are divided into 2 parts, one of the licorice is crushed and then soaked in water to prepare the first licorice solution, and then 1 / 2 of Angelica dahurica is added to decoct, and then 1 / 2 of Evodia rutaecarpa and Sinapis chinensis are added to decoct, and a Chinese medicine extraction enzyme is added for enzymolysis;

[0011] S3, add 1 / 2 of Piper serrata, cumin, and cinnamon to the liquid in step S2 and continue to boil, finally add prickly ash and black pepper and boil, then take out the medicinal materials to obtain liquid medicine;

[0012] S4, subjecting the medicinal solution of step S3 to reflux extraction and reduced pressure concentration to obtain a concentrated medicinal solution;

[0013] S5, crushing another portion of licorice and soaking it in clean water to prepare a second licorice solution, then adding the medicinal materials taken out in step S3 and continuing to heat, then taking out the medicinal materials and filtering them to obtain an intermediate medicinal solution;

[0014] S6, drying the remaining 1 / 2 of angelica dahurica, evodia rutaecarpa, cinnamon bark, piper longifolia, cumin, yellow mustard, prickly ash, and black pepper, stir-frying, and grinding to prepare a powder, sieving the powder several times to obtain the powder, adding the intermediate liquid to the powder, and stirring to prepare an ointment;

[0015] S7, concentrating the ointment, air-drying it, grinding it, and sieving it to make ointment powder;

[0016] S8, adding the concentrated liquid medicine of step S3 to the ointment powder, stirring evenly, concentrating under reduced pressure, air-drying, grinding, sieving to form fine powder;

[0017] S9, after sterilizing the fine powder, entering the soft capsule packaging production line to prepare soft capsules.

[0018] Furthermore, in step S2, the amount of clean water is 180-240 parts; and in step S4, the amount of clean water is 120-140 parts.

[0019] Furthermore, in step S2, the licorice solution is soaked for 40-60 minutes, and the heating temperature after adding Angelica dahurica is 90-100° C. for 15-25 minutes.

[0020] Furthermore, in step S2, the heating temperature after adding Evodia rutaecarpa and yellow mustard seeds is 80-90°C, the heating time of Evodia rutaecarpa is 10-15 minutes, and the yellow mustard seeds are added after an interval of 5 minutes.

[0021] Furthermore, in step S3, the heating time after adding piper longum, cumin and cinnamon is 10-15 minutes; the heating time after adding prickly ash and black pepper is 5 minutes.

[0022] Furthermore, in step S2, the temperature for adding the Chinese medicine extraction enzyme is 30°C, the Chinese medicine extraction enzyme is composed of cellulase, pectinase and xylanase in a mass ratio of 2:3:1, and the Chinese medicine extraction enzyme accounts for 2-4% of the weight of all raw medicinal materials.

[0023] Furthermore, in step S7, the grinding fineness of the ointment powder is 400 nanometers.

[0024] Furthermore, in step S8, the grinding fineness of the medicinal powder is 300 nanometers.

[0025] The medicinal material of the present invention:

[0026] Angelica dahurica is pungent and warm, can dispel wind and relieve pain, dispel cold and relieve the symptoms, can travel between the skin and the surface, is good at going up and down, can well relieve the pain of the head, and has antipyretic, anti-inflammatory, analgesic and antispasmodic effects. Evodia rutaecarpa is pungent, bitter and hot, can dispel cold and relieve pain, reduce adverse reactions and stop vomiting, help yang and stop diarrhea, and is used to treat Jueyin headache, and has the effects of relieving pain, relieving cough and expelling cold, and removing dampness and blood stasis; Licorice has the effects of tonifying the spleen and replenishing qi, relieving urgency and relieving pain, etc., which can not only enhance the synergistic effect between drugs, but also relieve the toxicity and potency of drugs, and reduce the adverse reactions of drugs. Cinnamon has the effects of dilating blood vessels, promoting blood circulation, enhancing coronary and cerebral blood flow, anti-platelet aggregation, anti-thrombin, sedation, analgesia, antipyretic, anticonvulsant, promoting intestinal function, enhancing digestive function, relieving gastrointestinal spasmodic pain, anti-ulcer, hypoglycemic, antibacterial, etc. Piper has the effects of warming the middle and dispelling cold, promoting qi and relieving pain, assisting cough and phlegm, warming the kidney and yang, and warming the stomach. Cinnamon has multiple pharmacological effects such as dilating blood vessels, promoting blood circulation, enhancing coronary and cerebral blood flow, anti-platelet aggregation, anti-thrombin, sedation, analgesia, antipyretic, anticonvulsant, promoting intestinal function, enhancing digestive function, relieving gastrointestinal spasmodic pain, anti-ulcer, hypoglycemic, antibacterial, etc. Fennel is spicy and has the effect of regulating the body's qi and making it unobstructed, and eliminating pain. It has a therapeutic effect on testicular prolapse, hypochondriasis, and dysmenorrhea. Yellow mustard enters the lung meridian and can be used to treat symptoms such as cough, wheezing, qi reversal, asthma, and sticky sputum caused by lung dryness. It can also promote blood circulation in the body and is used to treat symptoms such as chest pain, rib pain, dysmenorrhea, irregular menstruation, and traumatic injuries caused by qi and blood stasis. It has a promoting effect on the body's metabolism and warming the meridians and unblocking the collaterals, and treats symptoms such as cold stomach pain, arthralgia, and headache. Zanthoxylum bungeanum contains rich phosphorus and iron, and is pungent and warm in nature. It enters the spleen, lung and kidney meridians and can be used to treat stomach and abdominal cold pain, vomiting, diarrhea, schistosomiasis, roundworms and other symptoms. It has the effects of dispelling cold and relieving pain, antibacterial and insecticidal, and increasing appetite. Black pepper has the effect of treating cold phlegm and food accumulation, and also has the effect of relieving cold pain in the abdomen, warming the meridians and relieving pain.

[0027] The beneficial effects of the present invention are:

[0028] 1. The compound analgesic capsule of the present invention is prepared by selecting drugs based on the principle of "pain due to obstruction" in traditional Chinese medicine. Traditional Chinese medicine is used to promote qi and relieve pain, so that the qi in the body is unblocked and blood circulates, and various diseases and pains are relieved. The raw medicinal materials in the present invention: Angelica dahurica and fennel are compatible to promote qi and relieve pain, and have a good curative effect on pain caused by qi stagnation. The compatibility of fennel and Evodia rutaecarpa has the effect of dispelling cold and relieving pain, can warm and dredge the meridians, and has a good relieving effect on pain caused by wind, cold and dampness. Cinnamon is pungent and hot, has the effect of replenishing fire and yang, dispelling cold and relieving pain, and can be used to treat spleen and kidney yang deficiency, cold pain in the abdomen, poor appetite and loose stools. Yellow mustard can promote blood circulation, and has a good relieving effect on symptoms such as chest pain, rib pain, dysmenorrhea and irregular menstruation caused by qi and blood stasis. Cinnamon can promote blood circulation and dredge the meridians, dispel cold and relieve pain. Yellow mustard is compatible with cinnamon, which can treat asthma caused by kidney deficiency, cold phlegm blocking the lungs, complex wind and cold, and reduce pain all over the body. Piper longum is pungent and hot, and has the effect of warming the middle and relieving pain. It and cinnamon are both very pungent and hot. The two are used together to complement each other. They are used to treat spleen and kidney yang deficiency, cold and chronic diarrhea caused by endogenous cold, and the efficacy is greatly increased. At the same time, black pepper is pungent and hot, and it belongs to the stomach and large intestine meridians. It has the effect of warming the middle and relieving pain. When used with Piper longum, it can increase the effect of dispersing superficial heat and relieving pain. Licorice can relieve drug toxicity and increase drug efficacy. It can be used with other drugs to enhance drug efficacy.

[0029] 2. In the present invention, a medicinal liquid is first prepared, and then the medicinal liquid is concentrated. The intermediate medicinal liquid is mixed with medicinal powder to prepare ointment powder. The concentrated medicinal liquid is then mixed with the ointment powder to prepare the final medicinal powder. After multiple steps to change the performance of the drug, the concentrated medicinal liquid is finally mixed with the ointment powder to prepare the fine powder which can maximize the efficacy of the drug.

[0030] 3. In the present invention, according to the performance and function of various medicinal materials, the number of medicinal materials is selected and the boiling time is determined, so that the active ingredients of the medicine can be effectively precipitated, the toxicity of toxic drugs can be reduced, and the volatilization of active ingredients due to too long boiling time can be avoided, so as to ensure the maximization of the efficacy of the medicine.

[0031] 4. In the present invention, when the medicine is decocted, enzymes are added to the medicine solution to enhance the activity of the medicine, improve the efficiency of medicine production, and decompose the macromolecules in the medicine to effectively precipitate them for easy absorption by the human body.

[0032] Other advantages, objectives and features of the present invention will be described in the following description and will be apparent to those skilled in the art to some extent, or those skilled in the art may be taught from the practice of the present invention. The objectives and other advantages of the present invention may be realized and obtained through the following description. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] In order to make the purpose, technical solution and beneficial effects of the invention clearer, the present invention provides the following drawings for illustration:

[0034] Figure 1 It is a preparation flow chart of the present invention. DETAILED DESCRIPTION

[0035] A method for preparing a compound soft capsule for analgesia.

[0036] Example 1

[0037] S1. Remove impurities from 120 parts of Angelica dahurica, 80 parts of Evodia rutaecarpa, 60 parts of Cinnamon bark, 40 parts of Piper scutellariae, 60 parts of Cuminum foenum-graecum, 40 parts of Sinapis chinensis, 20 parts of Zanthoxylum bungeanum, 20 parts of Black pepper and 90 parts of Licorice, wash and dry them in the sun;

[0038] S2, the medicinal materials are divided into 2 parts, one of which is crushed and then added with 180 parts of clean water to soak for 10 minutes to prepare the first licorice solution, and then 60 parts of Angelica dahurica are added and first decocted at 95°C for 20 minutes, then 40 parts of Evodia rutaecarpa are added and decocted at 85°C for 12 minutes, and then 20 parts of yellow mustard seeds are added and decocted for 5 minutes, and 2% of the weight of the medicinal materials is added with a Chinese medicine extraction enzyme for enzymolysis;

[0039] S3, add 20 parts of Piper serrata, 30 parts of fennel, and 30 parts of cinnamon to the liquid in step S2, and continue to boil for 10 minutes, and finally add 10 parts of Zanthoxylum bungeanum and 10 parts of black pepper and boil for 5 minutes, and then take out the medicinal materials to obtain the liquid;

[0040] S4, refluxing and extracting the medicinal solution in step S3, and concentrating under reduced pressure to 0.8 times the amount of the medicinal solution to obtain a concentrated medicinal solution;

[0041] S5, crush another portion of licorice and add 120 portions of clean water to soak, to prepare a second licorice solution, then add the medicinal material taken out in step S3 and continue heating for 10 minutes, then take out the medicinal material and filter to obtain an intermediate medicinal solution;

[0042] S6. Dry the remaining angelica dahurica, evodia rutaecarpa, cinnamon bark, piper longifolia, cumin, yellow mustard, prickly ash, and black pepper, stir-fry, and grind to prepare a powder, sieve the powder three times to obtain the powder, add the intermediate drug solution to the powder, stir for 15 minutes, and prepare an ointment;

[0043] S7, grinding and sieving the ointment after concentrating and air-drying to prepare ointment powder with a particle size of 400 nanometers;

[0044] S8, adding the concentrated liquid medicine of step S3 to the ointment powder and stirring evenly, air-drying after decompression concentration, grinding and sieving to form a fine powder with a particle size of 300 nanometers;

[0045] S9, after sterilizing the fine powder, entering the soft capsule packaging production line to prepare soft capsules.

[0046] During the preparation of the present invention, the angelica root which needs to be decocted for a long time is first placed in the first liquorice solution and boiled for a long time to ensure the effective precipitation of the components; then the drugs such as Evodia rutaecarpa and Sinapis chinensis are placed in the middle for boiling; and the drugs such as Piper scutellariae, cumin and cinnamon which do not need to be boiled for too long are boiled for a short time to avoid the volatilization of the effective components; finally, black pepper, Zanthoxylum bungeanum and the like are added for the final boiling.

[0047] Example 2

[0048] S1. Remove impurities from 140 parts of Angelica dahurica, 100 parts of Evodia rutaecarpa, 75 parts of cinnamon bark, 60 parts of Piper scutellariae, 70 parts of cumin, 60 parts of yellow mustard seeds, 30 parts of Zanthoxylum bungeanum, 30 parts of black pepper and 100 parts of liquorice, wash and dry them in the sun;

[0049] S2, the medicinal materials are divided into 2 parts, one of which is crushed and then added with 180 parts of clean water to soak for 10 minutes to prepare the first licorice solution, and then 70 parts of Angelica dahurica are added and first decocted at 95°C for 20 minutes, then 50 parts of Evodia rutaecarpa are added and decocted at 85°C for 12 minutes, and then 30 parts of yellow mustard seeds are added and decocted for 5 minutes, and 2% of the weight of the medicinal materials is added with a Chinese medicine extraction enzyme for enzymolysis;

[0050] S3, add 30 parts of Piper serrata, 35 parts of fennel, and 37.5 parts of cinnamon to the liquid in step S2, and continue to boil for 10 minutes, and finally add 15 parts of Zanthoxylum bungeanum and 15 parts of black pepper and boil for 5 minutes, and then take out the medicinal materials to obtain the liquid;

[0051] S4, refluxing and extracting the medicinal solution in step S3, and concentrating under reduced pressure to 0.8 times the amount of the medicinal solution to obtain a concentrated medicinal solution;

[0052] S5, crush another portion of licorice and add 120 portions of clean water to soak, to prepare a second licorice solution, then add the medicinal material taken out in step S3 and continue heating for 10 minutes, then take out the medicinal material and filter to obtain an intermediate medicinal solution;

[0053] S6. Dry the remaining angelica dahurica, evodia rutaecarpa, cinnamon bark, piper longifolia, cumin, yellow mustard, prickly ash, and black pepper, stir-fry, and grind to prepare a powder, sieve the powder three times to obtain the powder, add the intermediate drug solution to the powder, stir for 15 minutes, and prepare an ointment;

[0054] S7, grinding and sieving the ointment after concentrating and air-drying to prepare ointment powder with a particle size of 400 nanometers;

[0055] S8, adding the concentrated liquid medicine of step S3 to the ointment powder and stirring evenly, air-drying after decompression concentration, grinding and sieving to form a fine powder with a particle size of 300 nanometers;

[0056] S9, after sterilizing the fine powder, entering the soft capsule packaging production line to prepare soft capsules.

[0057] The difference between Example 2 and Example 1 is that the parts of each raw material component are different, but both are within the scope of the present invention.

[0058] Example 3

[0059] S1. Remove impurities from 130 parts of Angelica dahurica, 80 parts of Evodia rutaecarpa, 75 parts of Cinnamon bark, 40 parts of Piper scutellariae, 60 parts of Cuminum foenum-leaf, 60 parts of Sinapis chinensis, 25 parts of Zanthoxylum bungeanum, 25 parts of Black pepper and 100 parts of Licorice, wash and dry them in the sun;

[0060] S2, the medicinal materials are divided into 2 parts, one of which is crushed and then added with 180 parts of clean water to soak for 10 minutes to prepare the first licorice solution, and then 65 parts of Angelica dahurica are added and first decocted at 95°C for 20 minutes, then 40 parts of Evodia rutaecarpa are added and decocted at 85°C for 12 minutes, and then 30 parts of yellow mustard seeds are added and decocted for 5 minutes, and 2% of the weight of the medicinal materials is added with a Chinese medicine extraction enzyme for enzymolysis;

[0061] S3, add 20 parts of Piper serrata, 30 parts of fennel, and 37.5 parts of cinnamon to the liquid in step S2, and continue to boil for 10 minutes, and finally add 12.5 parts of Zanthoxylum bungeanum and 12.5 parts of black pepper and boil for 5 minutes, and then take out the medicinal materials to obtain the liquid;

[0062] S4, refluxing and extracting the medicinal solution in step S3, and concentrating under reduced pressure to 0.8 times the amount of the medicinal solution to obtain a concentrated medicinal solution;

[0063] S5, crush another portion of licorice and add 120 portions of clean water to soak, to prepare a second licorice solution, then add the medicinal material taken out in step S3 and continue heating for 10 minutes, then take out the medicinal material and filter to obtain an intermediate medicinal solution;

[0064] S6. Dry the remaining angelica dahurica, evodia rutaecarpa, cinnamon bark, piper longifolia, cumin, yellow mustard, prickly ash, and black pepper, stir-fry, and grind to prepare a powder, sieve the powder three times to obtain the powder, add the intermediate drug solution to the powder, stir for 15 minutes, and prepare an ointment;

[0065] S7, grinding and sieving the ointment after concentrating and air-drying to prepare ointment powder with a particle size of 400 nanometers;

[0066] S8, adding the concentrated liquid medicine of step S3 to the ointment powder and stirring evenly, air-drying after decompression concentration, grinding and sieving to form a fine powder with a particle size of 300 nanometers;

[0067] S9, after sterilizing the fine powder, entering the soft capsule packaging production line to prepare soft capsules.

[0068] The difference between Example 3 and Example 1 is that the parts of each raw material component are different, but both are within the scope of the present invention.

[0069] In order to demonstrate the superiority of the raw materials, methods and conditions of the present invention, Comparative Examples 1 to 3 are set up here.

[0070] Comparative Example 1

[0071] S1. Remove impurities from 180 parts of Angelica dahurica, 50 parts of Evodia rutaecarpa, 100 parts of cinnamon bark, 30 parts of Piper scutellariae, 20 parts of cumin, 120 parts of yellow mustard seeds, 60 parts of Zanthoxylum bungeanum, 50 parts of black pepper and 60 parts of liquorice, wash and dry them in the sun;

[0072] S2, the medicinal materials are divided into 2 parts, one of which is crushed and then added with 180 parts of clean water to soak for 10 minutes to prepare the first licorice solution, and then 90 parts of Angelica dahurica are added and first decocted at 95°C for 20 minutes, then 25 parts of Evodia rutaecarpa are added and decocted at 85°C for 12 minutes, and then 60 parts of yellow mustard seeds are added and decocted for 5 minutes, and 2% of the weight of the medicinal materials is added with a Chinese medicine extraction enzyme for enzymolysis;

[0073] S3, add 15 parts of Piper serrata, 10 parts of cumin, and 50 parts of cinnamon to the liquid in step S2 and continue to boil for 10 minutes, finally add 30 parts of Zanthoxylum bungeanum and 25 parts of black pepper and boil for 5 minutes, then take out the medicinal materials to obtain the liquid;

[0074] S4, refluxing and extracting the medicinal solution in step S3, and concentrating under reduced pressure to 0.8 times the amount of the medicinal solution to obtain a concentrated medicinal solution;

[0075] S5, crush another portion of licorice and add 120 portions of clean water to soak, to prepare a second licorice solution, then add the medicinal material taken out in step S3 and continue heating for 10 minutes, then take out the medicinal material and filter to obtain an intermediate medicinal solution;

[0076] S6. Dry the remaining angelica dahurica, evodia rutaecarpa, cinnamon bark, piper longifolia, cumin, yellow mustard, prickly ash, and black pepper, stir-fry, and grind to prepare a powder, sieve the powder three times to obtain the powder, add the intermediate drug solution to the powder, stir for 15 minutes, and prepare an ointment;

[0077] S7, grinding and sieving the ointment after concentrating and air-drying to prepare ointment powder with a particle size of 400 nanometers;

[0078] S8, adding the concentrated liquid medicine of step S3 to the ointment powder and stirring evenly, air-drying after decompression concentration, grinding and sieving to form a fine powder with a particle size of 300 nanometers;

[0079] S9, after sterilizing the fine powder, entering the soft capsule packaging production line to prepare soft capsules.

[0080] The difference between Comparative Example 1 and Example 1 is that the raw material components are not within the protection scope of the present invention, and some raw materials are too much / too little.

[0081] Comparative Example 2

[0082] S1. Remove impurities from 60 parts of cinnamon bark, 40 parts of piper longum, 60 parts of fennel, 40 parts of yellow mustard seeds, 20 parts of prickly ash, 20 parts of black pepper and 90 parts of liquorice, wash and dry them in the sun;

[0083] S2, the medicinal material is divided into 2 parts, one part of the licorice is crushed and then added to 180 parts of clean water to soak for 10 minutes to prepare a first licorice solution, and then 20 parts of yellow mustard are added to boil for 5 minutes, and 2% of the weight of the medicinal material is added with a traditional Chinese medicine extraction enzyme for enzymolysis;

[0084] S3, add 20 parts of Piper serrata, 30 parts of fennel, and 30 parts of cinnamon to the liquid in step S2, and continue to boil for 10 minutes, and finally add 10 parts of Zanthoxylum bungeanum and 10 parts of black pepper and boil for 5 minutes, and then take out the medicinal materials to obtain the liquid;

[0085] S4, refluxing and extracting the medicinal solution in step S3, and concentrating under reduced pressure to 0.8 times the amount of the medicinal solution to obtain a concentrated medicinal solution;

[0086] S5, crush another portion of licorice and add 120 portions of clean water to soak, to prepare a second licorice solution, then add the medicinal material taken out in step S3 and continue heating for 10 minutes, then take out the medicinal material and filter to obtain an intermediate medicinal solution;

[0087] S6. Dry the remaining angelica dahurica, evodia rutaecarpa, cinnamon bark, piper longifolia, cumin, yellow mustard, prickly ash, and black pepper, stir-fry, and grind to prepare a powder, sieve the powder three times to obtain the powder, add the intermediate drug solution to the powder, stir for 15 minutes, and prepare an ointment;

[0088] S7, grinding and sieving the ointment after concentrating and air-drying to prepare ointment powder with a particle size of 400 nanometers;

[0089] S8, adding the concentrated liquid medicine of step S3 to the ointment powder and stirring evenly, air-drying after decompression concentration, grinding and sieving to form a fine powder with a particle size of 300 nanometers;

[0090] S9, after sterilizing the fine powder, entering the soft capsule packaging production line to prepare soft capsules.

[0091] The difference between Comparative Example 2 and Example 1 is that Angelica dahurica and Evodia rutaecarpa are not added.

[0092] Comparative Example 3

[0093] S1. Remove impurities from 120 parts of Angelica dahurica, 80 parts of Evodia rutaecarpa, 60 parts of Cinnamon bark, 40 parts of Piper scutellariae, 60 parts of Cuminum foenum-graecum, 40 parts of Sinapis chinensis, 20 parts of Zanthoxylum bungeanum, 20 parts of Black pepper and 90 parts of Licorice, wash and dry them in the sun;

[0094] S2. Grind all the medicinal materials to prepare powder. After the powder is sterilized, it enters the soft capsule packaging production line to be prepared into soft capsules.

[0095] The difference between Comparative Example 3 and Example 1 is that the preparation method is different.

[0096] The performance of the capsules of Examples 1 to 3 and Comparative Examples 1 to 3 was tested. 18 adults with different degrees of pain were selected and randomly divided into 6 groups. Each group of people took the capsules of Examples 1 to 3 and Comparative Examples 1 to 3 respectively every day. After taking them for 7 consecutive days, their performance is shown in Table 1:

[0097]

[0098]

[0099] As can be seen from the above table, after taking the soft capsules prepared by the embodiments of the present invention 1-embodiment 3, the symptoms of pain all over the body and depression of the experimenter are effectively alleviated, and the medicine has no other effects and will not cause additional harm to the body. After taking the soft capsules of comparative example 1-comparative example 3, due to the use of the different drug portions and preparation methods of the present invention, the experimenter either has no obvious improvement in pain phenomenon or causes additional side effects, and can not be effectively applied to human body for taking. Therefore, only the soft capsules prepared by the medicine, portion, and method of the present invention can achieve the purpose of the present invention, and the conditions have changed and all cannot reach the effect of the present invention.

[0100] Finally, it should be noted that the above preferred embodiments are only used to illustrate the technical solutions of the present invention rather than to limit it. Although the present invention has been described in detail through the above preferred embodiments, those skilled in the art should understand that various changes can be made in form and details without departing from the scope defined by the claims of the present invention.

Claims

1. A compound soft capsule for analgesia, characterized in that: By weight, the medicinal materials in the soft capsule include 120-140 parts of angelica dahurica, 80-100 parts of evodia rutaecarpa, 80-100 parts of liquorice, 60-75 parts of cinnamon, 40-60 parts of piperita lancea, 50-70 parts of fennel, 40-60 parts of yellow mustard seeds, 20-30 parts of prickly ash, and 20-30 parts of black pepper.

2. A compound soft capsule for analgesia according to claim 1, characterized in that: The medicinal materials in the soft capsule are 130 parts of angelica dahurica, 90 parts of evodia rutaecarpa, 90 parts of liquorice, 68 parts of cinnamon bark, 50 parts of piperita lancea, 60 parts of cumin, 50 parts of yellow mustard seeds, 25 parts of prickly ash and 25 parts of black pepper.

3. A compound soft capsule for analgesia according to any one of claims 1-2, further comprising a method for preparing the compound soft capsule for analgesia, characterized in that: The following steps are included: S1. Remove impurities from angelica dahurica, evodia rutaecarpa, cinnamon bark, piper longifolia, cumin, yellow mustard, prickly ash, black pepper and liquorice, wash and dry them in the sun; S2, the medicinal materials are divided into 2 parts, one of the licorice is crushed and then soaked in water to prepare the first licorice solution, and then 1 / 2 of Angelica dahurica is added to decoct, and then 1 / 2 of Evodia rutaecarpa and Sinapis chinensis are added to decoct, and a Chinese medicine extraction enzyme is added for enzymolysis; S3, add 1 / 2 of Piper serrata, cumin, and cinnamon to the liquid in step S2 and continue to boil, finally add prickly ash and black pepper and boil, then take out the medicinal materials to obtain liquid medicine; S4, subjecting the medicinal solution of step S3 to reflux extraction and reduced pressure concentration to obtain a concentrated medicinal solution; S5, crushing another portion of licorice and soaking it in clean water to prepare a second licorice solution, then adding the medicinal materials taken out in step S3 and continuing to heat, then taking out the medicinal materials and filtering them to obtain an intermediate medicinal solution; S6, drying the remaining 1 / 2 of angelica dahurica, evodia rutaecarpa, cinnamon bark, piper longifolia, cumin, yellow mustard, prickly ash, and black pepper, stir-frying, and grinding to prepare a powder, sieving the powder several times to obtain the powder, adding the intermediate liquid to the powder, and stirring to prepare an ointment; S7, grinding and sieving the ointment after concentrating and air-drying it to prepare ointment powder; S8, adding the concentrated liquid medicine of step S3 to the ointment powder, stirring evenly, concentrating under reduced pressure, air-drying, grinding, sieving to form fine powder; S9, after sterilizing the fine powder, entering the soft capsule packaging production line to prepare soft capsules.

4. A method for preparing a compound soft capsule for analgesia according to claim 3, characterized in that: In step S2, the amount of clean water is 180-240 parts; in step S4, the amount of clean water is 120-140 parts.

5. A method for preparing a compound soft capsule for analgesia according to claim 3, characterized in that: In step S2, the licorice solution is soaked for 40-60 minutes, and the heating temperature after adding Angelica dahurica is 90-100° C. for 15-25 minutes.

6. A method for preparing a compound soft capsule for analgesia according to claim 3, characterized in that: In the step S2, the heating temperature after adding Evodia rutaecarpa and yellow mustard seeds is 80-90°C, the heating time of Evodia rutaecarpa is 10-15 minutes, and the yellow mustard seeds are added after an interval of 5 minutes.

7. A method for preparing a compound soft capsule for analgesia according to claim 3, characterized in that: In the step S3, the heating time after adding the piper longum, cumin and cinnamon is 10-15 minutes; the heating time after adding the prickly ash and black pepper is 5 minutes.

8. A method for preparing a compound soft capsule for analgesia according to claim 3, characterized in that: In the step S2, the temperature for adding the Chinese medicine extracting enzyme is 30°C, the Chinese medicine extracting enzyme is composed of cellulase, pectinase and xylanase in a mass ratio of 2:3:1, and the Chinese medicine extracting enzyme accounts for 2-4% of the weight of all raw medicinal materials.

9. A method for preparing a compound soft capsule for analgesia according to claim 3, characterized in that: In step S7, the grinding fineness of the ointment powder is 400 nanometers.

10. The method for preparing a compound soft capsule for analgesia according to claim 3, characterized in that: In the step S8, the powder is ground to a fineness of 300 nanometers.

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