Zhuang medicine composition, Zhuang medicine liquid and medicated thread for treating polycystic ovarian syndrome and application of Zhuang medicine composition, Zhuang medicine liquid and medicated thread

Abstract

The invention provides a Zhuang medicine composition, Zhuang medicine liquid and medicated thread for treating polycystic ovarian syndrome and application of the Zhuang medicine composition, the Zhuang medicine liquid and the medicated thread, and belongs to the technical field of polycystic ovarian syndrome treatment. The Zhuang medicine composition for treating polycystic ovarian syndrome provided by the invention is prepared from the following raw materials: agilawood, sandalwood, berchemia lineata, tongcao, citronella, folium artemisiae argyi, cynanchum paniculatum, cinnamon, fructus evodiae, rhizoma acori graminei, asiatic toddalia root, rhizoma cyperi and musk. The Zhuang medicine composition provided by the invention conditions the internal secretion of PCOS patients and improves the ovarian reserve function through the comprehensive effects of warming yang and dispelling cold, promoting blood circulation to remove blood stasis and soothing liver-qi stagnation, so that the pregnancy probability of the patients is increased, and the pregnancy outcome is improved. The Zhuang medicine composition and the unique medicated thread point moxibustion therapy of Zhuang medicine are combined for use for the first time, the dual effects of medicine and acupuncture are achieved in the mode that the medicated threads stimulate the acupuncture points, and the Zhuang medicine composition has good and remarkable effects in the aspects of regulating endocrine metabolism of PCOS patients and improving clinical symptoms.

Description

Technical Field

[0001] The invention belongs to the technical field of polycystic ovary syndrome treatment, and specifically relates to a Zhuang medicine composition, Zhuang medicine liquid, medicine thread and application thereof for treating polycystic ovary syndrome. Background Art

[0002] Polycystic Ovary Syndrome (PCOS) is a common endocrine and metabolic disease characterized by high androgen levels, ovulatory disorders, and polycystic ovarian morphological features. The clinical manifestations of PCOS are diverse, and patients may have metabolic disorders such as menstrual disorders, infertility, obesity, insulin resistance, and type 2 diabetes. Although some progress has been made in the clinical diagnosis and treatment of PCOS, its etiology and pathogenesis are still not completely clear, and may involve the interaction of multiple factors such as genetics, environment, metabolism, and endocrine. In recent years, the relationship between PCOS and metabolic disorders has gradually attracted the attention of researchers. Studies have shown that insulin resistance in PCOS patients is closely related to chronic low-grade inflammation, which provides a new direction for exploring the pathological mechanism and therapeutic targets of the disease. At present, the treatment strategy of PCOS mainly focuses on symptom management, including improving menstrual cycles, reducing high androgen levels, and controlling weight. However, although traditional treatments such as oral contraceptives and insulin sensitizers have certain efficacy in relieving symptoms, long-term use may cause side effects and cannot fundamentally change the patient's pathological state. Therefore, finding more effective treatment strategies with fewer side effects has become the focus of PCOS prevention and treatment. Summary of the invention

[0003] In view of this, the object of the present invention is to provide a Zhuang medicine composition, Zhuang medicine liquid, medicine thread and application thereof for treating polycystic ovary syndrome, which can exert the dual effects of medicine and acupuncture by stimulating acupoints through the medicine thread.

[0004] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0005] The invention provides a Zhuang medicine composition for treating polycystic ovary syndrome. The Zhuang medicine composition comprises the following raw materials in parts by weight: 10 parts of agarwood, 5 parts of sandalwood, 15 parts of iron-wrapped gold, 10 parts of eighteen symptoms, 15 parts of citronella, 10 parts of wormwood, 10 parts of bamboo shoots, 3 parts of cinnamon bark, 5 parts of evodia rutaecarpa, 10 parts of calamus, 10 parts of dragon palm blood, 10 parts of cyperus and 5 parts of musk.

[0006] The present invention also provides a Zhuang medicine liquid for treating polycystic ovary syndrome, which is obtained by soaking the Zhuang medicine composition in alcohol.

[0007] Preferably, the volume fraction of the alcohol is 95%.

[0008] Preferably, the soaking time is more than 3 days.

[0009] The present invention also provides a medicine thread for treating polycystic ovary syndrome, wherein the medicine thread is a medicine thread with the above-mentioned strengthening medicine liquid.

[0010] Preferably, the drug thread is ramie drug thread.

[0011] The present invention also provides the use of the Zhuang medicine composition, the Zhuang medicine liquid or the Zhuang medicine thread in preparing a product for treating polycystic ovary syndrome.

[0012] Preferably, Zhuang medicine thread moxibustion therapy is used to treat polycystic ovary syndrome.

[0013] Preferably, the Zhuang medicine thread moxibustion therapy includes one press to extinguish the fire as one Zhuang, one moxibustion on one acupoint as one Zhuang, one time a day, and 7 times as one course of treatment.

[0014] Preferably, the acupoints include Guanyuan acupoint, Zusanli acupoint, Shangjuxu acupoint, Taichong acupoint, Zhongji acupoint and Sanyinjiao acupoint.

[0015] Beneficial effects of the present invention:

[0016] The present invention combines the Zhuang medicine composition with the unique Zhuang medicine thread moxibustion therapy for the first time, and exerts the dual effects of medicine and acupuncture by stimulating acupoints with the thread, showing good effects and significant effects in regulating the endocrine metabolism and improving clinical symptoms of PCOS patients. The Zhuang medicine composition provided by the present invention regulates the endocrine of PCOS patients and improves the ovarian reserve function through the comprehensive effects of warming yang and dispelling cold, promoting blood circulation and removing blood stasis, and soothing the liver and relieving depression, thereby increasing the probability of pregnancy and improving the pregnancy outcome of patients. The scheme for treating PCOS provided by the present invention is a non-invasive treatment method with few side effects, easy for patients to accept, and high compliance. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 The weight changes of mice in each group during the experiment, **P<0.01, ***P<0.001, ****P<0.0001;

[0018] Figure 2 The results of estrous cycle monitoring during the experiment for each group of mice, from left to right, are blank group, disease group and treatment group;

[0019] Figure 3 The statistical results of fertility and umbilical cord blood flow of mice in each group, the left figure is the fertility results, the right figure is the umbilical cord blood flow results, *P<0.05, **P<0.01, ****P<0.0001;

[0020] Figure 4The results of the changes in hormone levels of mice in each group, from left to right and from top to bottom are FSH, LH, AMH and testosterone, ***P < 0.001, ****P < 0.0001, ns means P ≥ 0.05;

[0021] Figure 5 The OGTT test results of mice in each group, from left to right are the results of the first week, the second week and the third week, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001;

[0022] Figure 6 The results of HE staining (4x magnification) of the ovaries of mice in each group, from left to right, are the results of the blank group, disease group and treatment group;

[0023] Figure 7 The HE staining results (4x magnification) of the livers of mice in each group, from left to right are the results of the blank group, disease group and treatment group respectively. DETAILED DESCRIPTION

[0024] The invention provides a Zhuang medicine composition for treating polycystic ovary syndrome. The Zhuang medicine composition comprises the following raw materials in parts by weight: 10 parts of agarwood, 5 parts of sandalwood, 15 parts of iron-wrapped gold, 10 parts of eighteen symptoms, 15 parts of citronella, 10 parts of wormwood, 10 parts of bamboo shoots, 3 parts of cinnamon bark, 5 parts of evodia rutaecarpa, 10 parts of calamus, 10 parts of dragon palm blood, 10 parts of cyperus and 5 parts of musk.

[0025] The present invention has no special limitation on the specific sources of the above-mentioned medicinal flavors. In the Zhuang medicine composition of the present invention, the agarwood is also known as Chenyangduo, the iron-wrapped gold is also known as Gouhounuo, the eighteen symptoms is also known as Kesuihong, the lemongrass is also known as Kechaha, the wormwood is also known as Mengai, the Diaozhu is also known as Banglanghuan, the cinnamon is also known as Nenggui, the Evodia rutaecarpa is also known as Kecha La, the stone calamus is also known as Kexiren, and the Feilongzhangxue is also known as Wenxiao. In the present invention, the musk is preferably natural musk.

[0026] In the Zhuang medicine composition of the present invention, agarwood and sandalwood are the main drugs (main drugs). Agarwood has the effects of warming and promoting the circulation of qi and blood, promoting qi circulation and relieving pain in the whole composition, can effectively regulate qi stagnation and blood stasis, improve ovarian function, and play a leading role in the treatment of PCOS. The effects of sandalwood in the whole composition are regulating qi and relieving pain, warming the middle and dispersing cold, harmonizing the stomach and regulating menstruation. It complements agarwood and constitutes a core drug pair for regulating qi, directly acts on the pathological links such as qi stagnation and blood stasis, meridian blockage, etc. of PCOS patients, and regulates endocrine through synergistic effects, and improves core symptoms such as irregular menstruation and insulin resistance.

[0027] In the Zhuang medicine composition of the present invention, the auxiliary medicine (adjuvant) is composed of the following medicinal flavors:

[0028] Gouhounuo (iron-coated gold): promotes blood circulation and removes blood stasis, enhances the prescription's regulating effect on blood circulation, and further improves ovarian function;

[0029] Ke Sui Hong (Eighteen Symptoms): It has the effect of regulating qi and blood, and assists in the treatment of gynecological diseases;

[0030] Kochaha (Lemongrass): It has the function of regulating Qi and relieving depression, helping to soothe emotions and regulate the balance of Qi and blood in the body;

[0031] Nenggui (Cinnamon Bark): Warms the yang and dispels cold, enhances the warming and tonic effect of prescriptions, and is suitable for treating symptoms caused by cold and dampness;

[0032] Mugwort: It has the functions of warming the menstruation and relieving pain, regulating menstruation, helping to regulate women’s menstrual cycle and improving the symptoms of PCOS;

[0033] Banglanghuan (Liaodiaozhu): Liaodiaozhu has the effect of clearing away heat and detoxifying, and can be used to relieve the symptoms of heat and toxicity in the body. It has a certain regulating effect on endocrine disorders and reproductive system infections caused by inflammation. While clearing away heat and removing dampness, it cooperates with the main medicine (agarwood, sandalwood) and auxiliary medicine (such as iron-wrapped gold, lemongrass) to improve metabolic and circulatory disorders caused by damp heat or blood stasis, and help regulate the overall symptoms of PCOS;

[0034] Kecha La (Evodia rutaecarpa): warms the yang and dispels cold, regulates qi and relieves pain, and assists in treating symptoms caused by cold and dampness;

[0035] Kexiren (Acorus calamus): It has the effects of refreshing the mind, regulating qi and removing dampness, and helps improve symptoms caused by excessive moisture in the body;

[0036] Cyperus rotundus: It has the functions of soothing the liver and relieving depression, regulating menstruation and relieving pain. It can help regulate menstrual disorders and relieve emotional problems.

[0037] Wen Xiao (Flying Dragon Palm Blood): It has a strong blood-activating effect, can improve blood circulation, promote the elimination of blood stasis, and relieve the common blood stasis syndrome in PCOS (such as scanty menstruation, amenorrhea, etc.). Combined with natural musk (a meridian-guiding drug), it enhances the blood-activating and collateral-draining effect of the overall prescription, allowing the drug to act more accurately on the ovaries and reproductive system.

[0038] In the Zhuang medicine composition of the present invention, the carrying medicine (guiding medicine) is natural musk, which has the effects of promoting blood circulation and removing blood stasis, regulating qi and relieving pain, can accelerate the effect of the medicine, promote blood circulation, regulate qi and blood in the body, and mobilize the effects of the main medicine and the auxiliary medicine.

[0039] The theoretical system of the Zhuang medicine composition of the present invention for treating PCOS is as follows:

[0040] ① Qi stagnation and blood stasis: A common pathological feature of PCOS is Qi stagnation and blood stasis, which manifests as symptoms such as irregular menstruation, dysmenorrhea, and ovarian enlargement. The pathological mechanism of Qi stagnation and blood stasis often leads to blocked meridians and poor blood circulation, cold stagnation and heat burning, blood stasis, blood stasis blocking Chong and Ren, blocking the menstrual blood from reaching the uterus, and causing amenorrhea or infertility. The agarwood, sandalwood, iron-wrapped gold, and dragon palm blood in the Zhuang medicine composition of the present invention have the effect of promoting qi and blood circulation, can dredge qi and blood, relieve qi stagnation and blood stasis, improve ovarian blood supply and function, and promote normalization of menstruation. Gouhounong (iron-wrapped gold) and Cyperus rotundus are also important drugs for promoting blood circulation and removing blood stasis, dredging meridians, which can further regulate blood circulation, eliminate the influence of blood stasis on the ovaries, and promote reproductive function.

[0041] ② Liver depression and qi stagnation: Liver qi stagnation is common in PCOS patients, which manifests as mood swings, depression, anxiety, weight gain, etc. Liver qi stagnation can affect the normal functions of organs such as the spleen, stomach, and kidneys, and then affect the menstrual cycle and ovulation. The cyperus rotundus, citronella, and calamus in the Zhuang medicine composition of the present invention have the effects of soothing the liver and relieving depression, regulating qi, and can dredge liver qi, alleviate emotional problems, and thus regulate the balance of qi and blood in the body. The qi-promoting effect of agarwood also helps to relieve liver qi and improve endocrine levels.

[0042] ③ Spleen deficiency and dampness: PCOS patients often have symptoms of spleen deficiency and dampness, which leads to excessive moisture in the body, causing metabolic abnormalities, obesity, and glucose metabolism disorders. Internal dampness may also affect menstrual regularity and lead to infertility and other problems. Kexiren (Acorus calamus), Kechaha (Cymbopogon citratus), Kechala (Evodia rutaecarpa), and Banglanghuan (Liaodiaozhu) have the functions of regulating qi and removing dampness, drying dampness and strengthening the spleen, which can help remove moisture from the body and improve metabolic function. The blood-activating and blood-stasis-removing effects of natural musk and Feilongzhangxue also help to strengthen the spleen and stomach functions and promote the removal of moisture from the body.

[0043] ④ Kidney deficiency: PCOS patients have insufficient endowment, weak constitution, or early marriage and sexual intercourse, which damages kidney qi, lacks the source of Tiangui, and has empty blood sea. Especially women who suffer from irregular menstruation and ovarian cysts for a long time are prone to menstrual disorders and ovarian dysfunction, often accompanied by symptoms of kidney deficiency, such as backache, fatigue, dizziness, dark complexion, etc. Although there is no direct kidney-tonifying drug in the Zhuang medicine composition of the present invention, the cinnamon bark and wormwood leaf therein have the effects of warming yang and warming and tonifying, which can indirectly promote the promotion of kidney yang, thereby helping to regulate ovarian function. In addition, the warm and hot drugs in the Zhuang medicine composition of the present invention can improve the function of the kidney by warming the meridians and promoting the circulation of qi and blood.

[0044] ⑤ Internal resistance of cold and dampness: Some PCOS patients may suffer from symptoms such as delayed menstruation, abdominal pain, and lumps due to heavy cold and dampness in the body. Internal resistance of cold and dampness hinders the circulation of qi and blood and affects the normal function of the ovaries. Cinnamon, Evodia rutaecarpa, Artemisia argyi, etc. in the Zhuang medicine composition of the present invention have the effects of warming yang, dispelling cold, and removing dampness, which can effectively warm the cold and dampness in the body, promote qi and blood circulation, and eliminate the adverse effects caused by internal resistance of cold and dampness.

[0045] In summary: the Zhuang medicine composition of the present invention takes into account the common symptoms and pathological mechanisms of PCOS patients, and specifically exerts the pharmacological effects of the medicine, which can regulate qi and blood, relieve liver depression, dissipate dampness and warm yang, and promote blood circulation and remove blood stasis. Through the comprehensive effects of warming yang and dispelling cold, promoting blood circulation and removing blood stasis, and relieving liver depression, it helps to regulate the menstrual cycle, restore ovarian function, and improve the core problem of PCOS. Moreover, it regulates the patient's physique in many aspects and improves the symptoms.

[0046] The present invention also provides a Zhuang medicine liquid for treating polycystic ovary syndrome, which is obtained by soaking the Zhuang medicine composition in alcohol. In the present invention, the volume fraction of the alcohol is preferably 95%; the soaking time is preferably more than 3 days. The present invention has no special restrictions on the specific amount of alcohol, and the alcohol can cover the Zhuang medicine composition.

[0047] The present invention also provides a drug thread for treating polycystic ovary syndrome, wherein the drug thread is a drug thread with the above-mentioned Zhuang medicine liquid. In the present invention, the drug thread is preferably soaked in the above-mentioned Zhuang medicine liquid, and the drug thread and alcohol can also be added to the above-mentioned Zhuang medicine composition, soaked for more than 3 days, and the drug thread is taken out for use. In the present invention, the drug thread is preferably a ramie drug thread, and the diameter of the ramie drug thread is preferably 0.7mm. After soaking, it is preferably twisted for use.

[0048] The present invention also provides the use of the Zhuang medicine composition, the Zhuang medicine liquid or the Zhuang medicine thread in preparing a product for treating polycystic ovary syndrome.

[0049] In the application of the present invention, it is preferred to use Zhuang medicine thread moxibustion therapy to treat polycystic ovary syndrome. In the present invention, the moxibustion method is preferably to hold one end of the medicine thread in the right hand, expose the thread head by 1 to 2 cm, and ignite it on the light. When the thread head burns to a bead fire, the right hand quickly presses the spark thread head directly on the acupoint with the flexion of the wrist and thumb. One press of the fire is extinguished, which is 1 Zhuang. 1 acupoint moxibustion is 1 Zhuang, 1 time a day, 7 times is 1 course of treatment, and rest 3d between courses. In the application of the present invention, the acupoints preferably include Guanyuan acupoint, Zusanli acupoint, Shangjuxu acupoint, Taichong acupoint, Zhongji acupoint and Sanyinjiao acupoint. The Zusanli acupoint, Shangjuxu acupoint, Taichong acupoint and Sanyinjiao acupoint are preferably double acupoints. When performing acupoint moxibustion, it is preferred to disinfect each acupoint first, and then perform acupoint moxibustion. The disinfection is preferably carried out using alcohol with a volume fraction of 75%. When using the medicinal thread provided by the present invention for acupuncture moxibustion, it is important to extinguish the flame after igniting the medicinal thread, and moxibustion can only be performed after the thread end burns into a round bead-shaped charcoal spark. When moxibustion is performed on body acupuncture points, the tip of the spark thread should be quickly pressed directly on the acupuncture point with the tip of the thumb. After moxibustion, the moxibustion site should be prevented from getting wet or being blown by cold wind.

[0050] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0051] In the following embodiments, unless otherwise specified, all of them are conventional methods.

[0052] Unless otherwise specified, the materials and reagents used in the following examples can be obtained from commercial sources.

[0053] Example 1

[0054] A Zhuang medicine composition for treating polycystic ovary syndrome is composed of the following raw materials: 10g of agarwood, 5g of sandalwood, 15g of iron-wrapped gold, 10g of eighteen symptoms, 15g of lemongrass, 10g of wormwood, 10g of bamboo shoots, 3g of cinnamon bark, 5g of evodia rutaecarpa, 10g of calamus, 10g of dragon palm blood, 10g of cyperus and 5g of natural musk.

[0055] Example 2

[0056] A Zhuang medicine liquid for treating polycystic ovary syndrome is prepared by soaking the Zhuang medicine composition of Example 1 in 95% alcohol by volume for 3 days to obtain the Zhuang medicine liquid.

[0057] Example 3

[0058] A medicinal thread for treating polycystic ovary syndrome is obtained by the following preparation method: adding ramie medicinal thread with a diameter of 0.7 mm and alcohol with a volume fraction of 95% into the Zhuang medicine composition of Example 1, soaking for 3 days, taking out the medicinal thread, and twisting it for standby use.

[0059] The method of using the medicine thread is as follows: use 75% alcohol by volume to disinfect Guanyuan acupoint, two Zusanli acupoints, two Shangjuxu acupoints, two Taichong acupoints, Zhongji acupoint and two Sanyinjiao acupoints, hold one end of the medicine thread in the right hand, expose 1 cm of the thread end, light it on a lamp, and when the thread end burns to a bead fire, press the spark thread end directly on the acupoint with the flexion of the wrist and thumb of the right hand, one press to extinguish the fire is one concentration, one acupoint is moxibustion one concentration, once a day, 7 times as a course of treatment, and rest for 3 days between courses.

[0060] Note that the flame must be extinguished after lighting the medicine thread, and moxibustion can only be performed after the thread end burns into a round charcoal spark. When moxibustion is performed on body acupoints, use the tip of the thumb to quickly press the spark thread end directly on the acupoint. After moxibustion, avoid getting the moxibustion area wet or blowing cold wind on the body.

[0061] Example 4

[0062] 4.1 Animal grouping

[0063] After 33 female mice were adaptively raised for one week, 11 female C5 mice were randomly selected as the blank group, and the remaining 22 females were used to establish the PCOS model. The male mice used for mating were not treated specially. Letrozole was given by intragastric administration at 1 mg / kg per day for 21 consecutive days, and vaginal exfoliated cells were detected every day. After the model was established, the 22 PCOS mice were randomly divided into the disease group and the treatment group, and OGTT tests were performed every week.

[0064] 4.2 Modeling

[0065] Blank group: SPF laboratory room temperature 20-25℃, humidity 50%-60%, fed with ordinary feed;

[0066] PCOS group: Letrozole 1 mg / kg was administered orally daily and the patients were fed with a high-fat diet for 21 consecutive days. The dose was gradually adjusted according to body weight gain.

[0067] 4.3 Drug intervention

[0068] After the model was established, intervention was carried out after the 22nd day. The blank group was not treated, and the treatment group was treated with the medicated thread in Example 3 for medicated thread moxibustion treatment every day. The specific method was the same as that in Example 3, with one course of treatment of 7 days, and a total of 3 courses; the disease group did not receive any treatment.

[0069] 4.4 Experimental Results

[0070] During the modeling period, the body weight of mice in the third week and thereafter, the disease group was compared with the blank group, with significant statistical differences of P < 0.001 and P < 0.0001; after the intervention began in the third week, the weight growth of the treatment group began to slow down in the fourth week, and the statistical difference between the treatment group and the disease group in the fourth week and thereafter was P < 0.01 and P < 0.0001 (see Figure 1). After testing the estrous cycle of mice, it was found that the disease group had a disordered estrous cycle and no estrus period, and the treatment group began to have irregular estrous cycles around the third week of treatment (see Figure 2 ). The fertility test of each group of mice found that the fertility of the mice in the disease group was significantly reduced or infertile. The ultrasound test of the umbilical cord blood flow of pregnant mice in each group found that the umbilical cord blood flow of pregnant mice in the disease group was significantly increased (see Figure 3 ). The serum of each group of mice was tested for AMH, FSH, LH and testosterone levels by ELISA. The results showed that compared with the blank group, the LH and testosterone levels of the mice in the disease group were significantly increased, P < 0.0001 and P < 0.001, respectively. Compared with the treatment group, P < 0.0001, while there was no significant statistical difference in FSH between the groups, P > 0.05. However, when comparing the LH / FSH ratio, the disease group was significantly higher than the blank group and the treatment group; compared with the blank group, the AMH in the disease group was significantly higher than that in the blank group, P < 0.0001, and compared with the treatment group, P < 0.0001 (see Figure 4 ).

[0071] In the medicated thread moxibustion, OGTT tests were performed on mice in each group. It was found that in the first week of intervention, the model group showed significant insulin resistance compared with the blank group (P < 0.0001), and there was no significant statistical difference compared with the treatment group. In the second week of treatment, blood sugar dropped significantly at 60 minutes compared with the treatment group (P < 0.05). In the third week of treatment, blood sugar dropped significantly at 15, 30, 60 and 120 minutes of OGTT compared with the treatment group, and insulin resistance was significantly improved, respectively (P < 0.01 or P < 0.0001 (see Figure 5 ).

[0072] HE staining of the ovaries and livers of mice in each group revealed that the ovarian follicles in the disease group were significantly dilated, and the primary and secondary follicles were significantly reduced. The follicle cystic expansion in the treatment group was significantly alleviated, and the primary and secondary oocytes were significantly increased compared with before. At the same time, many fat droplets were seen in the livers of mice in the disease group, indicating obvious fatty liver. The fat droplets in the livers of the treatment group were significantly smaller and less (see Figure 6 and Figure 7 ).

[0073] In summary, the medicated thread moxibustion of the present invention has multiple effects on improving high androgen expression, rare ovulation, insulin resistance, fertility disorders and hyperlipidemia of PCOS, and can increase the probability of pregnancy in patients and improve pregnancy outcomes.

[0074] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A medicinal composition for treating polycystic ovary syndrome, characterized in that: The Zhuang medicine composition includes the following raw materials in parts by weight: 10 parts of agarwood, 5 parts of sandalwood, 15 parts of iron-wrapped gold, 10 parts of eighteen symptoms, 15 parts of lemongrass, 10 parts of wormwood, 10 parts of bamboo shoots, 3 parts of cinnamon, 5 parts of evodia rutaecarpa, 10 parts of calamus, 10 parts of dragon palm blood, 10 parts of cyperus and 5 parts of musk.

2. A medicinal solution for treating polycystic ovary syndrome, characterized in that: The method is obtained by soaking the Zhuang medicine composition according to claim 1 in alcohol.

3. The Zhuang medicine liquid according to claim 2, characterized in that: The volume fraction of the alcohol is 95%.

4. The Zhuang medicine liquid according to claim 2, characterized in that: The soaking time is more than 3 days.

5. A drug line for treating polycystic ovary syndrome, characterized in that: The drug thread is a drug thread containing the strong medicine solution described in any one of claims 2 to 4.

6. The medical thread according to claim 5, characterized in that: The medicinal thread is ramie medicinal thread.

7. Use of the Zhuang medicine composition according to claim 1, the Zhuang medicine liquid according to any one of claims 2 to 4, or the medicine thread according to any one of claims 5 to 6 in the preparation of products for treating polycystic ovary syndrome.

8. The use according to claim 7, characterized in that: Polycystic ovary syndrome is treated with Zhuang medicine thread-moxibustion therapy.

9. The use according to claim 8, characterized in that: The Zhuang medicine thread moxibustion therapy includes one pressing to extinguish the fire as one Zhuang, one moxibustion on one acupoint as one Zhuang, one time a day, and 7 times as one course of treatment.

10. The use according to claim 9, characterized in that: The acupoints include Guanyuan acupoint, Zusanli acupoint, Shangjuxu acupoint, Taichong acupoint, Zhongji acupoint and Sanyinjiao acupoint.

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