Furosemide injection system based on brain natriuretic peptide monitoring

Abstract

The invention belongs to the technical field of medical instruments, and particularly discloses a furosemide injection system based on brain natriuretic peptide monitoring, the furosemide injection system comprises a detection module and a wearable device, the detection module is used for detecting the brain natriuretic peptide level in a human body in real time; the wearable device comprises a shell, an injection module, a control module and a medicine storage module and a connection relation thereof. The brain natriuretic peptide level in the body of a patient is detected in real time through the detection module, data of the brain natriuretic peptide level is sent to the control module, the control module analyzes and calculates the data, and then the control module controls the injection needle to inject furosemide into the human body or adjusts the injection amount of furosemide in real time according to the calculation result. Therefore, personalized treatment can be carried out according to individual differences of the patients and specific conditions of the patients, the treatment requirements of different patients are better met, and accurate treatment of the patients is achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a furosemide injection system based on brain natriuretic peptide monitoring. Background Art

[0002] Heart failure is a common clinical symptom. Heart failure is caused by the inability of the heart to pump blood normally to meet the body's metabolic needs. Chronic heart failure is a long-term disease that requires long-term drug treatment and management. Brain natriuretic peptide (BNP) is a hormone secreted by the heart's ventricular wall cells. When the heart load increases, the secretion of BNP increases, so the level of BNP can reflect the heart load. Furosemide is a commonly used diuretic that can be used to treat heart failure. Furosemide can reduce the heart load by promoting the excretion of urine.

[0003] In the existing technology, the method of using furosemide to treat chronic heart failure is usually to manually adjust the injection amount of furosemide by the doctor according to the patient's symptoms and experience. The disadvantage of this method is that the doctor is highly subjective and cannot accurately control the drug dosage, which can easily lead to excessive or insufficient drug treatment, resulting in poor treatment effect or increased drug side effects. Although there are some automated drug delivery systems that can automatically adjust the drug dosage according to pre-set parameters, this system lacks consideration of individual differences in patients, cannot provide personalized treatment according to the patient's specific situation, and cannot dynamically adjust according to real-time changing physiological parameters, and cannot achieve precise control of drug dosage. Summary of the invention

[0004] The purpose of the present invention is to solve the technical problems existing in the background technology. To this end, a furosemide injection system based on brain natriuretic peptide monitoring is provided, which can provide personalized and precise treatment according to the individual conditions of the patients.

[0005] In order to achieve the above object, the technical solution adopted by the present invention is as follows:

[0006] A furosemide injection system based on brain natriuretic peptide monitoring comprises a detection module and a wearable device, wherein the detection module is used to detect the level of brain natriuretic peptide in a human body in real time; the wearable device comprises a shell, an injection module, a control module and a drug storage module; the shell is used to be attached to the human body surface, and the injection module, the control module and the drug storage module are located in the shell; the drug storage module is connected to the injection module, and the drug storage module is used to store furosemide; the injection module is provided with an injection needle for passing through the shell and piercing the subcutaneous tissue of a human body, and the injection needle is used to inject furosemide into the human body; the control module is respectively connected to the detection module and the injection module for communication, and the control module obtains data on the level of brain natriuretic peptide in a human body through the detection module, and the control module controls the injection needle in real time to inject furosemide into the human body or adjust the injection amount of furosemide according to the data on the level of brain natriuretic peptide in the human body.

[0007] The following is a technical solution further defined in the present invention: the detection module is located in the housing, and the detection module is used to contact a human blood sample and detect the level of brain natriuretic peptide in the human body.

[0008] The following is a technical solution further defined in the present invention, wherein the injection needle is used to draw blood, and the detection module extends into the injection needle.

[0009] The following is a technical solution further defined in the present invention: the wearable device is provided with a blood collection needle, the blood collection needle is used to pierce the subcutaneous tissue of the human body, and the blood collection needle is connected to the detection module through a pipeline.

[0010] The following is a technical solution further defined by the present invention, wherein the detection module is wirelessly connected to the control module, and the detection module is used to be implanted in the body and detect the level of brain natriuretic peptide in the human body in real time.

[0011] The following is a technical solution further defined by the present invention, wherein the wearable device includes a mounting seat, and the drug storage module is detachably mounted on the mounting seat.

[0012] The following is a technical solution further defined in the present invention, wherein the control module adjusts the amount of furosemide used according to the deviation between the brain natriuretic peptide content in the human body and the target interval value through proportional, integral and differential control algorithms.

[0013] The following is a technical solution further defined in the present invention, which also includes a data storage module, which is communicatively connected to the control module, and the data storage module is used to store the brain natriuretic peptide level change data in the human body and the furosemide usage data detected by the detection module.

[0014] The following is a technical solution further defined in the present invention, which also includes a remote monitoring end, the wearable device includes a wireless signal transceiver module, the control module is wirelessly connected to the remote monitoring end through the wireless signal transceiver module, the control module sends the brain natriuretic peptide level change data and furosemide usage data detected by the detection module to the remote monitoring end through the wireless signal transceiver module, and the remote monitoring end is used to send an instruction to adjust the furosemide injection amount to the control module.

[0015] The following is a technical solution further defined in the present invention, wherein the wearable device includes an alarm module, and the alarm monitors the level of brain natriuretic peptide in the human body through the detection module. When the level of brain natriuretic peptide in the human body deviates from the interval value, the alarm module issues an alarm; the alarm module is used to detect the injection module, and when the injection module sends a fault, the alarm module issues an alarm.

[0016] Compared with the prior art, the present invention has the following technical effects:

[0017] The present invention detects the level of brain natriuretic peptide in the patient's body in real time through a detection module, and sends the data of the brain natriuretic peptide level to a control module. The control module analyzes and calculates the data, and then controls the injection needle to inject furosemide into the human body or adjust the injection amount of furosemide in real time according to the calculation result, so that personalized treatment can be performed according to the individual differences of the patients and the specific conditions of the patients, better meeting the treatment needs of different patients and achieving precise treatment of the patients; compared with the existing method of manually adjusting the drug dosage by doctors, it has higher accuracy and can effectively avoid the problem of poor treatment effect or increased drug side effects due to dosage deviation.

[0018] The present invention is further described below in conjunction with the accompanying drawings and embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0020] Figure 1 is a schematic diagram of a furosemide injection system based on brain natriuretic peptide monitoring according to an embodiment of the present invention;

[0021] Figure 2 is a schematic structural diagram of a wearable device shown in an embodiment of the present invention;

[0022] Figure 3is a schematic diagram of the internal structure of a wearable device shown in an embodiment of the present invention;

[0023] Figure 4 is a schematic structural diagram of a wearable device according to another embodiment of the present invention;

[0024] Figure 5 is a schematic diagram of the structure of a wearable device and a detection module shown in another embodiment of the present invention.

[0025] Figure numerals: wearable device 100; detection module 200; remote monitoring terminal 300; shell 1; adhesive plate 11; perforation 12; protective film 13; cover body 14; injection module 2; injection needle 21; injection pump 22; control module 3; drug storage module 4; mounting base 5; wireless signal transceiver module 6; alarm module 7; touch screen 8; blood collection needle 9. DETAILED DESCRIPTION

[0026] Embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. Although embodiments of the present invention are shown in the accompanying drawings, it should be understood that the present invention can be implemented in various forms and should not be limited by the embodiments described herein. On the contrary, these embodiments are provided to make the present invention more thorough and complete, and to fully convey the scope of the present invention to those skilled in the art.

[0027] It should be understood that although the terms "first", "second", "third", etc. may be used to describe various information in the present invention, such information should not be limited to these terms. These terms are only used to distinguish the same type of information from each other. For example, without departing from the scope of the present invention, the first information may also be referred to as the second information, and similarly, the second information may also be referred to as the first information. Thus, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "multiple" is two or more, unless otherwise clearly and specifically defined.

[0028] In the description of the present invention, it should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside" and "outside" etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0029] Unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, or a detachable connection or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0030] In view of the above problems, an embodiment of the present invention provides a furosemide injection system based on brain natriuretic peptide monitoring, which can provide personalized and precise treatment according to the individual conditions of patients.

[0031] The technical solutions of the embodiments of the present invention are described in detail below with reference to the accompanying drawings.

[0032] Figure 1 Schematic diagram of a furosemide injection system based on brain natriuretic peptide monitoring according to an embodiment of the present invention.

[0033] See also Figure 1 The furosemide injection system based on brain natriuretic peptide monitoring includes a detection module 200 and a wearable device 100. The detection module 200 is used to detect the level of brain natriuretic peptide in the human body in real time. The detection module 200 can be a BNP sensor, and the material of the BNP sensor can be a biocompatible material. The type of BNP sensor can be a sensor based on optics, electrochemistry or enzyme-linked immunosorbent assay (ELISA) to achieve high-sensitivity detection of BNP.

[0034] Figure 2 is a schematic structural diagram of a wearable device shown in an embodiment of the present invention; Figure 3 Schematic diagram of the internal structure of a wearable device according to an embodiment of the present invention.

[0035] See also Figure 1-3 The wearable device 100 includes a housing 1, an injection module 2, a control module 3, and a drug storage module 4. The housing 1 is used to be attached to the human body surface, and the housing 1 can be worn on the patient's arm or abdomen. In order to ensure that the housing 1 can be firmly fixed on the patient's body surface, in some embodiments, a ring-shaped elastic band can be provided on the housing 1, and the elastic band is put on the patient's arm or abdomen to make the housing 1 firmly attached to the body; in some embodiments, an adhesive plate 11 is provided on the side of the housing 1 facing the human body, and the housing 1 can be attached to the patient's arm or abdomen through the adhesive plate 11.

[0036] See also Figure 2 and Figure 3The injection module 2, the control module 3 and the drug storage module 4 are located in the housing 1, and the housing 1 can protect the injection module 2, the control module 3 and the drug storage module 4. The drug storage module 4 is connected to the injection module 2 through a pipeline, and the drug storage module 4 is used to store furosemide. The maximum capacity of the drug storage module 4 is 100mL. The injection module 2 includes an injection needle 21 and an injection pump 22. The injection pump 22 is respectively connected to the injection needle 21 and the drug storage module 4 through a pipeline. The maximum injection speed of the injection pump 22 is 200mL / h, and the maximum injection volume is 200mL.

[0037] See also Figure 2 and Figure 3 A perforation 12 is provided on the side of the shell 1 facing the human body, and the perforation 12 is provided on the adhesive plate 11. Before the wearable device 100 is not used, the perforation 12 is covered by a protective film 13. When the wearable device 100 needs to be used, the protective film 13 can be torn off. A charging port is provided on the surface of the shell 1, and a battery is provided in the shell 1. The charging port can be connected to an external wire to charge the battery, and the battery supplies power to the injection module 2 and the control module 3. The injection needle 21 is used to inject furosemide into the human body. The injection needle 21 is a retractable structure. Specifically, the injection needle 21 can be retracted and extended by a small motor, and the control module 3 controls the operation of the small motor. When the wearable device 100 is not in use, the injection needle 21 is located in the shell 1; when furosemide needs to be injected into the patient, the needle tip of the injection needle 21 can pass through the perforation 12 and penetrate into the subcutaneous tissue of the human body, and the injection pump 22 extracts furosemide from the drug storage module 4, and the injection pump 22 transports furosemide to the injection needle 21. The furosemide diffuses into the patient's blood through the needle tip of the injection needle 21 under the subcutaneous tissue of the human body, wherein the needle tip of the injection needle 21 can remain under the subcutaneous tissue of the human body for a long time.

[0038] See also Figure 1-3 , the control module 3 is respectively connected to the detection module 200 and the injection module 2 in communication, and the control module 3 can control the action of the injection needle 21 and the action of the injection pump 22. The data generated by the detection module 200 detecting the level of brain natriuretic peptide in the human body can be sent to the control module 3. After the control module 3 obtains the data of the level of brain natriuretic peptide in the human body, it analyzes and calculates the data of the level of brain natriuretic peptide in the human body, and the control module 3 controls the injection needle 21 to inject furosemide into the human body or adjust the injection amount of furosemide in real time according to the calculation result; if the level of brain natriuretic peptide in the patient's body is too high, the control module 3 can immediately control the injection needle 21 to inject furosemide into the human body, adjust the injection speed of furosemide or increase the injection amount of furosemide; if the level of brain natriuretic peptide in the patient's body is too low, the control module 3 can reduce the injection amount or injection speed of furosemide, so as to meet the injection needs of the individual patient, wherein the injection amount or injection speed of furosemide will be adjusted continuously over time, so as to produce a dynamic treatment course suitable for the individual patient.

[0039] The present invention detects the level of brain natriuretic peptide in the patient's body in real time through the detection module 200, and sends the data of the brain natriuretic peptide level to the control module 3. The control module 3 analyzes and calculates the data, and the control module 3 controls the injection needle 21 to inject furosemide into the human body or adjust the injection amount of furosemide in real time according to the calculation result, so that personalized treatment can be performed according to the individual differences of the patients and the specific conditions of the patients, better meet the treatment needs of different patients, and achieve precise treatment of the patients; compared with the existing method of manually adjusting the drug dosage by doctors, it has higher accuracy and can effectively avoid the problem of poor treatment effect or increased drug side effects due to dosage deviation.

[0040] Figure 4 It is a schematic diagram of the structure of a wearable device shown in another embodiment of the present invention.

[0041] See also Figure 4 In some embodiments, the detection module 200 is located in the housing 1. The detection module 200 can contact a human blood sample and detect the level of brain natriuretic peptide in the human blood sample. By integrating the wearable device 100 and the detection module 200 together, it is convenient for patients to use and reduces the burden on patients. The detection module 200 extends into the injection needle 21. In addition to injecting furosemide, the injection needle 21 can also extract blood samples. When the blood flows in the injection needle 21, the detection module 200 will contact the blood, so that the detection module 200 can detect the level of brain natriuretic peptide in the blood sample. By setting the detection module 200 and the injection needle 21 together, the internal space of the wearable device 100 is saved. When the wearable device 100 is in the injection mode, the needle of the injection needle 21 is located under the patient's skin, and the injection needle 21 can continue to inject; when the wearable device 100 is in the detection mode, the needle of the injection needle 21 is automatically pressed down, so that the needle of the injection needle 21 enters the blood, and the injection needle 21 collects blood samples and performs rapid detection, and sends the detected data to the control module 3.

[0042] Figure 5 is a schematic diagram of the structure of a wearable device and a detection module shown in another embodiment of the present invention.

[0043] See also Figure 5In some embodiments, the detection module 200 is located in the housing 1, and the detection module 200 is used to contact the human blood sample and detect the level of brain natriuretic peptide in the human body. The wearable device 100 also includes a blood collection needle 9 and a blood pump. The blood collection needle 9 is separated from the injection needle 21. The blood collection needle 9 is used to pierce the blood vessels in the subcutaneous tissue of the human body. The blood collection needle 9 can collect blood. The detection module 200 is connected to the blood pump and the blood collection needle 9 through a pipeline, respectively, and the control module 3 controls the operation of the blood pump. When the blood pump is working, the blood collection needle 9 can absorb the blood in the patient's blood vessels, and the blood flows from the blood collection needle 9 to the detection module 200. The detection module 200 detects the collected blood, and the detection module 200 sends the detection data to the control module 3. The control module 3 analyzes and calculates the brain natriuretic peptide level of the collected blood. The control module 3 determines the injection efficiency of the injection needle 21 according to the results of the analysis and calculation, and controls the injection pump 22 to work. The blood collection needle 9 can use a microneedle to reduce the probability of infection in the patient. By separating the blood collection needle 9 and the injection needle 21, multiple injections to the same part of the patient are avoided, thereby reducing the patient's pain. When the blood collection needle 9 is needed to collect a blood sample, the patient or doctor can choose automatic collection or manual collection mode, wherein automatic collection can be set to collect blood at a fixed time interval, and after the predetermined time is reached, the needle of the blood collection needle 9 automatically presses down to collect blood; manual collection is not restricted and can be collected at any time according to the needs of the patient or doctor.

[0044] In some embodiments, the detection module 200 is located in the housing 1. The detection module 200 does not have the function of collecting blood, but the detection module 200 can contact a human blood sample and detect the level of brain natriuretic peptide in the human body. The patient or doctor can collect a blood sample from the patient's fingertips or arms and other organs, place a small amount of blood sample in the detection module 200, and the detection module 200 detects the blood sample. The control module 3 controls the injection rate of brain natriuretic peptide based on the detection results.

[0045] See also Figure 1-3In some embodiments, the detection module 200 is implanted in the human body to monitor the level of brain natriuretic peptide in the human body in real time. The wearable device 100 includes a wireless signal transceiver module 6. The control module 3 is connected to the detection module 200 by wireless signals through the wireless signal transceiver module 6. The data detected by the detection module 200 is sent to the control module 3 through the wireless signal transceiver module 6. The wireless signal transceiver module 6 selects a wireless communication protocol suitable for medical devices, such as Bluetooth Low Energy (BLE) or Zigbee. The detection module 200 is a BNP sensor, which is arranged in a cardiac implant device. The cardiac implant device can be a pacemaker, an implantable cardioverter defibrillator, a cardiac resynchronization therapy CRT / CRTD, etc. The material of the BNP sensor selects biocompatible materials, such as medical grade polymers or metals, so as to reduce the rejection reaction in the implanted body. The measurement range of the BNP sensor is 0-5000pg / mL, and the measurement accuracy of the BNP sensor is ±10%.

[0046] See also Figure 2 and Figure 3 In some embodiments, the wearable device 100 includes a mounting seat 5, and the drug storage module 4 is detachably mounted on the mounting seat 5. When the furosemide in the drug storage module 4 is used up, the patient can take out the used drug storage module 4 and install a new drug storage module 4 on the mounting seat 5, which is convenient for the patient to replenish furosemide in time after the drug storage module 4 runs out of furosemide, avoiding accidents and reducing the cost of use. Figure 2 and Figure 3 In one embodiment, the housing 1 is provided with a cover 14, which is used to cover and protect the mounting seat 5. The cover 14 may be a sliding cover or a flip cover, and the patient may open the cover 14 to take out the medicine storage module 4 on the mounting seat 5. In one embodiment, the mounting seat 5 is a notch in the housing 1, and the medicine storage module 4 may be installed in the notch and combined with the housing 1 to form a rectangular whole.

[0047] See also Figure 2 and Figure 3, the control module 3 adjusts the amount of furosemide used according to the deviation between the brain natriuretic peptide content in the human body and the target interval value through the proportional, integral and differential (PID) control algorithm, so as to achieve precise control of the furosemide dosage. The PID control algorithm adopts adaptive PID control, and the parameter range is Kp=0.1-10, Ki=0.01-1, and Kd=0.01-5. The injection module 2 calculates the injection amount of furosemide through the PID control algorithm. The injection module 2 automatically adjusts the injection amount of furosemide according to the instructions of the control module 3. Preferably, the injection speed range of the injection needle 21 is 0.1-20mL / h, and the injection volume range is 0.1-20mL. Preferably, the detection frequency of the detection module 200 is once per hour, and the measurement accuracy is ±10%. The present invention adopts a (PID) control algorithm to improve the accuracy and response speed of the furosemide dosage adjustment. Compared with the automated drug delivery system in the prior art, it can be dynamically adjusted according to the patient's real-time physiological parameters to achieve precise control of the furosemide dosage and improve the therapeutic effect.

[0048] See also Figure 2 and Figure 3 In some embodiments, the furosemide injection system based on brain natriuretic peptide monitoring also includes a data storage module, which is communicatively connected to the control module 3. The data storage module is used to store the brain natriuretic peptide level change data and furosemide usage data in the human body detected by the detection module 200. The data storage module can also store the patient's treatment history. Preferably, the data storage module can store brain natriuretic peptide level change data, furosemide usage data and treatment history within three months. The control module 3 can analyze the patient's treatment history, brain natriuretic peptide level change data and furosemide usage data stored in the storage module, thereby analyzing the patient's treatment effect, and then adjust the parameters of the PID control algorithm accordingly to achieve a better treatment effect.

[0049] See also Figure 2 and Figure 3In some embodiments, the furosemide injection system based on brain natriuretic peptide monitoring also includes a remote monitoring terminal 300, which can be set up in a medical institution, and the doctor can operate the remote monitoring terminal 300 in the medical institution. The wearable device 100 includes a wireless signal transceiver module 6, and the wearable device 100 can be connected to the Internet through the wireless signal transceiver module 6, and the control module 3 is connected to the remote monitoring terminal 300 by wireless signals through the wireless signal transceiver module 6. The control module 3 sends the brain natriuretic peptide level change data and furosemide usage data detected by the detection module 200 to the remote monitoring terminal 300 through the wireless signal transceiver module 6, and the remote monitoring terminal 300 is used to send an instruction to adjust the furosemide injection amount to the control module 3. The doctor can view the patient's brain natriuretic peptide level change data and furosemide usage data in real time, and remotely adjust the parameters of the PID control algorithm or the furosemide usage plan through the remote monitoring terminal 300. The patient's treatment history, brain natriuretic peptide level change data, furosemide usage data and the patient's treatment effect stored in the data storage module can be sent to the remote monitoring terminal 300 through the wireless signal transceiver module 6 to provide decision support for doctors. Compared with the existing technology, it can better assist doctors in diagnosis and treatment, thereby improving the treatment effect.

[0050] See also Figure 2 and Figure 3 In some embodiments, the wearable device 100 includes an alarm module 7, which is connected to the control module 3 in communication. The alarm monitors the level of brain natriuretic peptide in the human body through the detection module 200. When the detection module 200 detects that the level of brain natriuretic peptide in the human body is out of the interval, the detection module 200 sends the data of the level of brain natriuretic peptide in the patient to the control module 3. The control module 3 analyzes and determines that the level of brain natriuretic peptide in the human body is out of the interval value. The control module 3 sends an instruction to the alarm module 7, and the alarm module 7 issues an alarm, wherein the interval value can be the normal range of brain natriuretic peptide level, and the normal range of brain natriuretic peptide level is 30-300 pg / mL. The alarm module 7 can also be connected to the injection module 2. The alarm module 7 can be used to detect the injection module 2. When the injection module 2 sends a fault, such as the injection pump 22 cannot work, the injection needle 21 is blocked, the injection rate is too fast, etc., the alarm module 7 issues an alarm, wherein the setting range of the injection rate is 0.1-20 mL / h. Specifically, the alarm module 7 includes a buzzer and / or a display light installed on the surface of the housing 1. When the alarm module 7 needs to sound an alarm, the display light flashes or the buzzer sounds. The alarm module 7 can be connected to the wireless signal transceiver module 6 for communication. When the alarm module 7 needs to sound an alarm, the alarm module 7 remotely sends an alarm to the remote monitoring terminal 300 and / or sends an alarm message to the APP installed on the family member's mobile phone through the wireless signal transceiver module 6 to ensure the patient's life safety.

[0051] See also Figure 2 and Figure 3 In some embodiments, the wearable device 100 further includes a sphygmomanometer for recording blood pressure and a heart rate monitor for recording heart rate. The control module 3 is respectively connected to the sphygmomanometer and the heart rate monitor for communication. The sphygmomanometer and the heart rate monitor can store the detected data in the data storage module, and the sphygmomanometer and the heart rate monitor can also directly send the detected data to the control module 3. The control module 3 comprehensively adjusts the injection amount of furosemide according to the patient's blood pressure, heart rate and brain natriuretic peptide parameters to achieve a more comprehensive treatment effect.

[0052] See also Figure 2 and Figure 3 In some embodiments, the wearable device 100 also includes a user interface, which includes a display screen and buttons. The display screen is installed on the surface of the shell 1. The display screen can display the patient's brain natriuretic peptide level, the amount and frequency of use of furosemide, blood pressure meter, heart rate and other information, which is convenient for patients and medical staff to view the patient's physical condition more intuitively. In addition, the display screen can be a touch screen 8, and the patient or doctor can operate the control module 3 on the touch screen 8 with the buttons, so as to control the injection amount of furosemide, the injection speed of furosemide, and adjust the parameters of the PID control algorithm.

[0053] The present invention can be widely used in the fields of heart failure treatment, chronic disease management, and automated control of medical equipment. In the field of heart failure treatment, the present invention provides a furosemide injection system based on brain natriuretic peptide monitoring, which can achieve accurate and effective treatment of heart failure patients and has important clinical application value; by real-time monitoring of brain natriuretic peptide levels and combining with an injection module 2 that can inject furosemide in time, accurate treatment can be achieved, the treatment effect can be improved, the number of hospitalizations and treatment costs of patients can be reduced, and the quality of life can be improved. In the field of chronic disease management, the present invention can achieve long-term, continuous and accurate management of chronic disease patients; by monitoring the real-time physiological parameters of patients and performing personalized treatment according to the specific conditions of patients, the efficiency and effect of chronic disease management can be effectively improved, and the pain and economic burden of patients can be reduced. In the field of automated control of medical equipment, the PID control algorithm, data storage module and control module 3 of the present invention cooperate to provide important reference and basis for the research and development and improvement of medical equipment. By continuously optimizing the PID control algorithm, the intelligence level of medical equipment can be improved, and more efficient and accurate medical services can be achieved.

[0054] The scheme of the present invention has been described in detail above with reference to the accompanying drawings. In the above embodiments, the description of each embodiment has its own emphasis. For parts that are not described in detail in a certain embodiment, reference can be made to the relevant descriptions of other embodiments. Those skilled in the art should also be aware that the actions and modules involved in the specification are not necessarily required for the present invention. In addition, it can be understood that the steps in the method of the embodiment of the present invention can be adjusted in order, merged and deleted according to actual needs, and the modules in the device of the embodiment of the present invention can be merged, divided and deleted according to actual needs.

[0055] The embodiments of the present invention have been described above, and the above description is exemplary, not exhaustive, and is not limited to the disclosed embodiments. Many modifications and changes will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The selection of terms used herein is intended to best explain the principles of the embodiments, practical applications, or improvements to the technology in the market, or to enable other persons of ordinary skill in the art to understand the embodiments disclosed herein.

Claims

1. A furosemide injection system based on brain natriuretic peptide monitoring, characterized in that: include: A detection module, wherein the detection module is used to detect the level of brain natriuretic peptide in the human body in real time; A wearable device, comprising a shell, an injection module, a control module and a drug storage module; the shell is used to be attached to the human body surface, and the injection module, the control module and the drug storage module are located inside the shell; the drug storage module is connected to the injection module, and the drug storage module is used to store furosemide; the injection module is provided with an injection needle used to pass through the shell and pierce the subcutaneous tissue of the human body, and the injection needle is used to inject furosemide into the human body; the control module is respectively communicated with the detection module and the injection module, and the control module obtains data on the level of brain natriuretic peptide in the human body through the detection module, and the control module controls the injection needle in real time to inject furosemide into the human body or adjust the injection amount of furosemide according to the data on the level of brain natriuretic peptide in the human body.

2. The furosemide injection system based on brain natriuretic peptide monitoring according to claim 1, characterized in that: The detection module is located in the housing, and is used to contact a human blood sample and detect the level of brain natriuretic peptide in the human body.

3. The furosemide injection system based on brain natriuretic peptide monitoring according to claim 2, characterized in that: The injection needle is used to draw blood, and the detection module extends into the injection needle.

4. The furosemide injection system based on brain natriuretic peptide monitoring according to claim 2, characterized in that: The wearable device is provided with a blood collection needle, which is used to pierce the subcutaneous tissue of the human body. The blood collection needle is connected to the detection module through a pipeline.

5. The furosemide injection system based on brain natriuretic peptide monitoring according to claim 1, characterized in that: The detection module is wirelessly connected to the control module, and the detection module is used to be implanted in the body and detect the level of brain natriuretic peptide in the human body in real time.

6. The furosemide injection system based on brain natriuretic peptide monitoring according to claim 1, characterized in that: The wearable device comprises a mounting seat, and the drug storage module is detachably mounted on the mounting seat.

7. The furosemide injection system based on brain natriuretic peptide monitoring according to claim 1, characterized in that: The control module adjusts the amount of furosemide used according to the deviation between the brain natriuretic peptide content in the human body and the target interval value through proportional, integral and differential control algorithms.

8. The furosemide injection system based on brain natriuretic peptide monitoring according to claim 1 or 7, characterized in that: It also includes a data storage module, which is in communication with the control module and is used to store the data on changes in brain natriuretic peptide levels in the human body and the data on the amount of furosemide used detected by the detection module.

9. The furosemide injection system based on brain natriuretic peptide monitoring according to claim 1 or 7, characterized in that: It also includes a remote monitoring end, the wearable device includes a wireless signal transceiver module, the control module is connected to the remote monitoring end by wireless signal via the wireless signal transceiver module, the control module sends the brain natriuretic peptide level change data and furosemide usage data detected by the detection module to the remote monitoring end via the wireless signal transceiver module, and the remote monitoring end is used to send instructions to adjust the furosemide injection amount to the control module.

10. The furosemide injection system based on brain natriuretic peptide monitoring according to claim 1, characterized in that: The wearable device includes an alarm module, which monitors the level of brain natriuretic peptide in the human body through the detection module. When the level of brain natriuretic peptide in the human body deviates from the interval value, the alarm module issues an alarm; the alarm module is used to detect the injection module, and when the injection module sends a fault, the alarm module issues an alarm.

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