Preparation system of carrier-free 177Lu solution

Abstract

The invention discloses a preparation system of a carrier-free 177Lu solution, relates to the technical field of medical radioisotope separation, and is used for separating a 176Yb target dissolving solution containing 177Lu and other lanthanide elements to obtain the 177Lu solution. The feeding end of a feeding module is connected with an inlet of a first separation column and an inlet of a second separation column through a first reversing valve. An inlet of the transfer container is communicated with an outlet of the first separation column, and an outlet of the transfer container is communicated with an inlet of the second separation column. In the first state, the material supply end of the material supply module is communicated with the inlet of the first separation column, the 177Lu-containing raw material liquid, the leacheate and the desorption liquid sequentially enter the first separation column to obtain the 177Lu-containing intermediate liquid through separation, and the 177Lu-containing intermediate liquid enters the transfer container. In the second state, the feeding end of the feeding module is communicated with the inlet of the second separation column, and the 177Lu-containing intermediate solution, the leacheate and the desorption solution sequentially enter the second separation column to be separated to obtain the carrier-free 177Lu solution. The method is used for preparing the carrier-free 177Lu solution.

Description

Technical Field

[0001] The present invention relates to the field of medical radioisotope separation technology, and more particularly to a carrier-free 177 Lu solution preparation system. Background Art

[0002] Since there is no carrier 177 Lu can be used in the preparation of targeted drugs such as peptides and monoclonal antibodies, so there is no carrier 177 The preparation of Lu is particularly important.

[0003] In the related art, generally, 176 Yb target was irradiated. 176 The Yb target is dissolved with acid and then separated to obtain 177 Lu. Due to the target nuclide 177 Lu and matrix nuclides 176 Yb are all lanthanide elements, with very similar chemical properties and can be separated 176 The amount of Yb is much greater than 177 Road volume, 176 Yb and 177 Lu molar ratio is usually greater than 2000, so from the constant 176 Yb is separated to obtain 177 Lu is extremely challenging. Summary of the invention

[0004] In order to solve the above technical problems, the present application provides a carrier-free 177 Lu solution preparation system for separation of 177 Lu and other lanthanide elements 176 Yb target solution to obtain 177 Lu solution.

[0005] This application is implemented through the following technical solutions.

[0006] The present application provides a carrier-free 177 The system for preparing Lu solution comprises a feed module, a first reversing valve, a first separation column, a transfer container and a second separation column. The feed module is used to provide 177 Lu raw material liquid, eluent and desorption liquid; the feeding end of the feeding module is connected to the inlet of the first separation column and the inlet of the second separation column through the first reversing valve; the inlet of the transfer container is connected to the outlet of the first separation column, and the outlet of the transfer container is connected to the inlet of the second separation column. When the first reversing valve is in the first state, the feeding end of the feeding module is connected to the inlet of the first separation column, including 177 Lu raw material solution, eluent and desorption liquid enter the first separation column in sequence to separate and obtain 177Lu intermediate solution, and contains 177 When the first reversing valve is in the second state, the feed end of the feed module is connected to the inlet of the second separation column, including 177 Lu intermediate solution, eluent and desorption solution enter the second separation column in sequence to separate and obtain carrier-free 177 Lu solution.

[0007] In the technical solution of the embodiment of the present application, the feeding end of the feeding module is connected to the inlets of the first separation column and the second separation column through the first reversing valve, and the outlet of the first separation column and the inlet of the second separation column are connected through the transfer container.

[0008] In the preparation of carrier-free 177 When Lu solution is added, the first reversing valve is first placed in the first state, so that the feed module is connected to the first separation column through the first reversing valve and is cut off from the second separation column. 177 Lu raw material liquid enters the first separation column, so that the first separation column contains 177 Lu raw material solution contains 177 Lu, and then the eluent enters the first separation column to remove the non-lanthanide impurities on the first separation column and retain 177 Lu, and then the desorption liquid enters the first separation column to remove 177 Lu and 176 Yb was desorbed at different time periods to obtain 177 Lu intermediate solution, and make it contain 177 The intermediate liquid enters the transfer container.

[0009] Then, the first reversing valve is switched to the second state, at which time the feeding end of the feeding module is connected to the inlet of the second separation column through the first reversing valve, and at the same time, the contents in the transfer container are 177 The Lu intermediate solution enters the second separation column, so that the second separation column will contain 177 Lu intermediate solution contains 177 Lu and other metal elements are adsorbed, and then the eluent enters the second separation column to remove impurities on the second separation column and retain 177 Lu, and then use the desorption liquid to remove the 177 Lu desorption to obtain carrier-free 177 Lu solution, thereby passing through the first separation column and the second separation column from 177 Carrier-free 177 Lu solution.

[0010] In the present application, the feed module, the first separation column, the second separation column, the first reversing valve and the transfer container are used to realize the separation of the containing 177 The double separation of Lu raw material solution and finally obtained high-purity carrier-free 177 Lu solution, the whole operation process is simple and convenient, and the separation effect is good.

[0011] In some embodiments of the present application, it further includes: a waste liquid container;

[0012] The second reversing valve, the outlet of the first separation column is connected to the inlet of the transfer container and the waste liquid container through the second reversing valve; the first separation column also produces the first waste liquid. When the second reversing valve is in the third state, the outlet of the first separation column is connected to the waste liquid container, and the first waste liquid enters the waste liquid container; when the second reversing valve is in the fourth state, the outlet of the first separation column is connected to the transfer container, containing 177 Lu intermediate liquid enters the transfer container;

[0013] and / or,

[0014] The outlet of the second separation column is connected to the outlet of the second separation column through the third reversing valve. 177 The Lu solution collection container and the waste liquid container are connected; the second separation column also produces a second waste liquid. When the third reversing valve is in the fifth state, the outlet of the second separation column is connected to the waste liquid container, and the second waste liquid enters the waste liquid container; when the third reversing valve is in the sixth state, the outlet of the second separation column is connected to the collection container, and there is no carrier. 177 The Lu solution enters the collection container.

[0015] Through the above arrangement, the second reversing valve can be used to separate the first waste liquid generated by the first separation column and the waste liquid containing 177 Lu intermediate liquid is divided into a waste liquid container and a transfer container, so as to facilitate the first waste liquid and the 177 Lu intermediate solution respectively. And / or, the second waste liquid generated by the second separation column and the carrier-free liquid can be separated by a third reversing valve. 177 Lu solution is divided into a waste liquid container and a collection container, thereby facilitating the second waste liquid and the carrier-free 177 Lu solutions are collected and processed separately.

[0016] In some embodiments of the present application, it also includes: a first radioactivity detector, which is arranged between the outlet of the first separation column and the second reversing valve, and is used to detect the radioactivity of the solution flowing out from the outlet of the first separation column. When the first radioactivity detector detects radioactivity, the second reversing valve switches to the fourth state; and / or, a second radioactivity detector, which is arranged between the outlet of the second separation column and the third reversing valve, and is used to detect the radioactivity of the solution flowing out from the outlet of the second separation column. When the second radioactivity detector detects radioactivity, the third reversing valve switches to the sixth state.

[0017] With the above settings, due to 177 Lu is able to launch γ Therefore, by setting a first radioactive detector, when the first radioactive detector detects that the solution flowing out of the outlet of the first separation column is radioactive, it is proved that the solution flowing out of the outlet of the first separation column contains 177 Lu, the second reversing valve can be switched to the fourth state to 177 The Lu intermediate solution is collected in a transfer container, and the peak time of radioactivity is determined by setting a first radioactivity detector to determine the collected content. 177 And / or, by setting a second radioactivity detector, when the second radioactivity detector detects that the solution flowing out of the outlet of the second separation column is radioactive, it is proved that the solution flowing out of the outlet of the second separation column contains 177 Lu, the third reversing valve can be switched to the sixth state to turn the carrier-free 177 The Lu solution is collected in a collection container, and the peak time of radioactivity is determined by setting a second radioactivity detector to determine the collection of carrier-free 177 Lu solution time.

[0018] In some embodiments of the present application, a first conducting pipe is connected between the outlet of the first separation column and the inlet of the second reversing valve, and the first conducting pipe passes through the shielding channel of the first radioactive detector; and / or a second conducting pipe is connected between the outlet of the second separation column and the inlet of the third reversing valve, and the second conducting pipe passes through the shielding channel of the second radioactive detector.

[0019] By providing a first conducting pipe, the outlet of the first separation column is connected to the second reversing valve, and the first conducting pipe passes through the shielding channel of the first radioactive detector, which not only facilitates the detection setting of the first radioactive detector, but also ensures the stability of the detection. And / or, by providing a second conducting pipe, the outlet of the second separation column is connected to the second reversing valve, and the second conducting pipe passes through the shielding channel of the second radioactive detector, which not only facilitates the detection setting of the second radioactive detector, but also ensures the stability of the detection.

[0020] In some embodiments of the present application, a pressure device is further included, and the outlet of the pressure device is connected to the first separation column and the second separation column through the first reversing valve. When the first reversing valve is in the first state, the outlet of the pressure device is connected to the inlet of the first separation column; and / or when the first reversing valve is in the second state, the outlet of the pressure device is connected to the inlet of the second separation column.

[0021] With the above arrangement, when the first reversing valve is in the first state, the outlet of the pressure applying device is connected to the first separation column through the first reversing valve, so that the pressure applying device can be a device containing 177 The flow of Lu raw liquid, eluent and desorption liquid provides power, thereby increasing the content 177 And / or, when the first reversing valve is in the second state, the outlet of the pressure device is connected to the second separation column through the first reversing valve, so that the pressure device can provide power for the flow of the eluent and the desorption liquid, thereby improving the separation efficiency of the carrier-free 177 Separation efficiency of Lu solution.

[0022] In some embodiments of the present application, the feeding module includes a plurality of containers and a fourth reversing valve, wherein the plurality of containers are respectively used to store 177 Lu raw material liquid, eluent and desorption liquid. The multiple inlets of the fourth reversing valve are respectively connected to the multiple containers, and the outlet of the fourth reversing valve is connected to the inlet of the first separation column and the inlet of the second separation column through the first reversing valve.

[0023] Through the above settings, multiple containers are used to store 177 Lu raw material liquid, eluent and desorption liquid, because multiple containers are connected to the first reversing valve through the fourth reversing valve, it is possible to achieve 177 Lu raw material solution, eluent and desorption solution are supplied separately in different time periods, which improves the convenience of system supply.

[0024] In some embodiments of the present application, the feeding module further includes a liquid level detector, which is disposed in a plurality of containers and is used to detect the liquid levels of the liquids in the plurality of containers.

[0025] The liquid level in the container is detected by the liquid level detector, so as to facilitate the 177 The reserves of Lu raw material liquid, eluent and desorption liquid are monitored to ensure that the liquid reserves in the container are sufficient to ensure normal and stable preparation.

[0026] In some embodiments of the present application, the preparation system further includes a column oven, and the first separation column and the second separation column are disposed in the column oven.

[0027] By setting a column temperature box, the first separation column and the second separation column are heated to the set temperature during the separation process to improve177 Separation effect of Lu.

[0028] In some embodiments of the present application, the first separation column is filled with a cation exchange resin; the desorption liquid includes: an α-hydroxyisobutyric acid solution, and when the first reversing valve is in the first state, the α-hydroxyisobutyric acid solution enters the first separation column.

[0029] Through the above settings, the α-hydroxyisobutyric acid solution can better 177 Lu and matrix elements 176 Yb separation.

[0030] In some embodiments of the present application, the desorption liquid further includes: hydrochloric acid of different concentrations, when the first reversing valve is in the second state, the hydrochloric acid enters the second separation column; the second separation column is filled with a phosphoric acid-containing leaching resin, and the phosphoric acid-containing leaching resin can adsorb the α-hydroxyisobutyric acid solution. 177 Lu.

[0031] By the above arrangement, higher concentration of hydrochloric acid can be used in desorption 177 Lu, so that α-hydroxyisobutyric acid such organic matter remains on the phosphoric acid-containing leaching resin, thereby preventing α-hydroxyisobutyric acid from entering the carrier-free 177 Lu solution to avoid the use of carrier-free 177 When Lu is used for targeted drug production, α-hydroxyisobutyric acid competes with the drug for labeling to ensure 177 Normal production of Lu drugs. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Various other advantages and benefits will become apparent to those of ordinary skill in the art by reading the detailed description of the preferred embodiments below. The accompanying drawings are only for the purpose of illustrating the preferred embodiments and are not to be considered as limiting the present application. Moreover, the same reference numerals are used throughout the drawings to represent the same components. In the drawings:

[0033] Figure 1 The carrier-free embodiment provided for some embodiments of the present application 177 A schematic diagram of the external structure of a Lu solution preparation system;

[0034] Figure 2 The carrier-free embodiment provided for some embodiments of the present application 177 Another schematic diagram of the external structure of the Lu solution preparation system;

[0035] Figure 3 The carrier-free embodiment provided for some embodiments of the present application 177 Another schematic diagram of the external structure of the Lu solution preparation system;

[0036] Figure 4 The carrier-free embodiment provided for some embodiments of the present application 177 Another schematic diagram of the external structure of the Lu solution preparation system.

[0037] Description of Reference Numerals

[0038] 01-No carrier 177 Lu solution preparation system; 1-feeding module; 11-container; 12-fourth reversing valve; 13-liquid level detector; 2-first reversing valve; 3-first separation column; 4-transfer container; 5-second separation column; 6-waste liquid container; 7-second reversing valve; 8-third reversing valve; 9-collecting container; 10-first radioactive detector; 101-second radioactive detector; 102-first conducting pipe; 103-second conducting pipe; 104-pressure device; 105-column temperature box;

[0039] a-liquid supply pipeline; a1-first pump body; a2-first one-way valve; b-first branch pipe; b1-second one-way valve; c-second branch pipe; c1-third one-way valve; d-first connecting pipe; e-second connecting pipe; e1-second pump body; e2-fourth one-way valve; f-third connecting pipe; g-fourth connecting pipe; h-fifth connecting pipe; i-collecting container; j-sixth connecting pipe; k-third pump body; l-seventh connecting pipe. DETAILED DESCRIPTION

[0040] The following embodiments of the technical solution of the present application are described in detail in conjunction with the accompanying drawings. The following embodiments are only used to more clearly illustrate the technical solution of the present application, and are therefore only used as examples, and cannot be used to limit the scope of protection of the present application.

[0041] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by technicians in the technical field to which this application belongs; the terms used herein are only for the purpose of describing specific embodiments and are not intended to limit this application; the terms "including" and "having" in the specification and claims of this application and the above-mentioned figure descriptions and any variations thereof are intended to cover non-exclusive inclusions.

[0042] In the description of the embodiments of the present application, the technical terms "first", "second", "third", etc. are only used to distinguish different objects, and cannot be understood as indicating or implying relative importance or implicitly indicating the number, specific order or primary and secondary relationship of the indicated technical features. In the description of the embodiments of the present application, the meaning of "multiple" is more than two, unless otherwise clearly and specifically defined.

[0043] Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0044] In the description of the embodiments of the present application, the term "and / or" is only a description of the association relationship of associated objects, indicating that three relationships may exist. For example, A and / or B can represent: A exists alone, A and B exist at the same time, and B exists alone. In addition, the character " / " in this article generally indicates that the associated objects before and after are in an "or" relationship.

[0045] In the description of the embodiments of the present application, the orientation or position relationship indicated by technical terms such as "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", and "circumferential" are based on the orientation or position relationship shown in the accompanying drawings. They are only for the convenience of describing the embodiments of the present application and simplifying the description, and do not indicate or imply that the referred system or element must have a specific orientation, be constructed, operated or used in a specific orientation. Therefore, they should not be understood as limitations on the embodiments of the present application.

[0046] In the description of the embodiments of the present application, unless otherwise clearly specified and limited, technical terms such as "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, and it can be the internal connection of two elements or the interaction relationship between two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the embodiments of the present application can be understood according to the specific circumstances.

[0047] In the description of the embodiments of the present application, unless otherwise clearly specified and limited, the technical term "contact" should be understood in a broad sense, and may be direct contact or contact through an intermediate medium layer. It may be contact with essentially no interaction force between the two contacting parties, or it may be contact with interaction force between the two contacting parties.

[0048] Below, this application is described in detail.

[0049] 177 Lu (lutetium-177) has a long half-life and emits beta particles and gamma rays. The beta particles have moderate energy and good coordination chemical properties. Therefore, it can be used in the preparation and application of targeted drugs such as peptides and monoclonal antibodies.

[0050] 177 Lu is divided into carrier 177 Lu and carrier-free 177 Lu. In the case of a carrier 177 Lu contains a large amount of non-radioactive reflux, which is not suitable for the preparation of targeted drugs such as peptides and monoclonal antibodies. 177 Lu does not contain non-radioactive Lu and has a high specific activity, so high-quality drugs can be obtained when used in the preparation of targeted drugs.

[0051] In the related art, there is no carrier 177 The preparation of Lu is generally divided into the following steps: first, 176 Yb (ytterbium-176) targets were irradiated to obtain 177 Lu and other lanthanide elements 176 Yb target, acid 176 After the Yb target is dissolved, a solution is obtained, and then the solution is separated to finally obtain 177 Lu solution.

[0052] However, due to the target nuclide 177 Lu and matrix nuclides 176 The chemical properties of Yb are very similar, so in the separation to obtain 177 When Lu solution is used, the operation is more difficult.

[0053] Based on this, Figure 1 As shown, the present application provides a carrier-free 177 The Lu solution preparation system 01 includes a feed module 1, a first reversing valve 2, a first separation column 3, a transfer container 4 and a second separation column 5. The feed module 1 is used to provide 177 Lu raw material liquid, eluent and desorption liquid. The feeding end of the feeding module 1 is connected to the inlet of the first separation column 3 and the inlet of the second separation column 5 through the first reversing valve 2. The inlet of the transfer container 4 is connected to the outlet of the first separation column 3, and the outlet of the transfer container 4 is connected to the inlet of the second separation column 5.

[0054] When the first reversing valve 2 is in the first state, the feeding end of the feeding module 1 is connected to the inlet of the first separation column 3, including 177 Lu raw material liquid, eluent and desorption liquid enter the first separation column 3 in sequence to separate and obtain 177 Lu intermediate solution, and contains 177 The Lu intermediate liquid enters the transfer container 4. When the first reversing valve 2 is in the second state, the feeding end of the feeding module 1 is connected to the inlet of the second separation column 5, including 177 Lu intermediate liquid, eluent and desorption liquid enter the second separation column 5 in sequence to separate and obtain carrier-free177 Lu solution.

[0055] It needs to be explained that the feeding end of the feeding module 1 is connected with the inlet of the first separation column 3 and the inlet of the second separation column 5 through the first reversing valve 2, which means that the first inlet of the first reversing valve 2 is connected with the feeding end of the feeding module 1, the first outlet of the first reversing valve 2 is connected with the inlet of the first separation column 3, and the second outlet of the first reversing valve 2 is connected with the inlet of the second separation column 5.

[0056] In this way, when the first reversing valve 2 is switched to the first state, the passage connecting the first inlet and the first outlet of the first reversing valve 2 is connected, so that the feeding end of the feeding module 1 is connected to the inlet of the first separation column 3. Similarly, when the first reversing valve 2 is switched to the second state, the passage connecting the first inlet and the second outlet of the first reversing valve 2 is connected, so that the feeding end of the feeding module 1 is connected to the inlet of the second separation column 5.

[0057] The first separation column 3 and the second separation column 5 are both chromatographic columns, and the first separation column 3 and the second separation column 5 are both filled with resin materials. 177 When the Lu raw material liquid passes through the first separation column 3, the resin material can adsorb the 177 Lu in the raw material solution 177 Lu and 176 Yb, in 177 When the Lu intermediate solution passes through the second separation column 5, the resin material can adsorb the 177 Lu in the intermediate solution 177 Lu and 176 Yb, so that when the eluent passes through the first separation column 3 and the second separation column 5, 177 Lu and 176 Yb and other non-lanthanide impurities. Then, the first separation column 3 is eluted with a desorption liquid to 177 Lu and 176 Yb separates and gets 177 Lu intermediate solution, and then use the desorption liquid to elute the second separation column 5 to remove a small amount of 176 Yb, finally obtained without carrier 177 Lu solution.

[0058] On this basis, before the separation operation is performed, the acidic solution and the aqueous solution may be passed through the first separation column 3 and the second separation column 5 so that the resin materials in the first separation column 3 and the second separation column 5 reach pre-equilibrium.

[0059] The first separation column 3 may have a column height of 500 mm and an inner diameter of 10 mm. The second separation column 5 may have a column height of 350 mm and an inner diameter of 10 mm.177 Lu intermediate solution 176 The Yb content is higher than that separated by the first separation column 3. 177 Lu raw material solution 176 The Yb content is low, so the size of the second separation column 5 can be slightly smaller than that of the first separation column 3 , which can not only ensure the concentration requirements of separation and purification, but also reduce the procurement costs of the first separation column 3 and the second separation column 5 .

[0060] In addition, 177 Lu raw material liquid can be used for 176 The Yb target was irradiated and the 176 Yb, 177 The target solution of Lu and other impurity elements. The eluent may include water, an acidic solution, etc. For example, the acidic solution may be HCl (hydrochloric acid), etc. The desorption liquid of the first separation column 3 may be an organic acid solution that can be complexed with rare earth elements, for example, it may include α-HIBA (α-hydroxyisobutyric acid), citric acid, etc. The desorption liquid of the second separation column 5 is HCl of gradient concentration.

[0061] In some examples, the feeding module 1 may include a plurality of containers 11, and the plurality of containers 11 are respectively used to hold 177 Lu raw material liquid, eluent and desorption liquid. Among them, the container 11 can be an ordinary glass bottle. Multiple containers 11 can be placed on the liquid rack.

[0062] In some examples, the transfer container 4 can be used to collect 177 A special container for Lu liquid, or an ordinary glass bottle.

[0063] Through the above arrangement, the feeding end of the feeding module 1 is connected to the inlets of the first separation column 3 and the second separation column 5 through the first reversing valve 2 , and the outlet of the first separation column 3 and the inlet of the second separation column 5 are connected through the transfer container 4 .

[0064] In the preparation of carrier-free 177 When Lu solution is added, the first reversing valve 2 is first placed in the first state, so that the feeding module 1 is connected to the first separation column 3 through the first reversing valve 2 and is cut off from the second separation column 5. 177 Lu raw material liquid enters the first separation column 3 (upper column), so that the first separation column 3 177 Lu in the raw material liquid 176 Yb, 177 Lu adsorption, and then the eluent enters the first separation column 3 to remove the impurity elements on the first separation column 3 and retain 176 Yb, 177 Lu, and then the desorption liquid enters the first separation column 3 to separate the177 Lu and 176 Yb desorption due to 177 Lu, 176 The retention time of the complex formed by Yb and the complexing agent on the resin in the first separation column 3 is different, so 177 Lu and 176 Yb can be eluted sequentially to collect 177 The components of Lu, namely 177 Lu intermediate solution, and make it contain 177 The Lu intermediate liquid enters the transfer container 4.

[0065] Then, the first reversing valve 2 is switched to the second state. At this time, the feeding end of the feeding module 1 is connected to the inlet of the second separation column 5 through the first reversing valve 2, and the contents in the transfer container 4 are 177 The Lu intermediate solution enters the second separation column 5, so that the second separation column 5 contains 177 Lu intermediate solution contains 177 Lu and a small amount 176 Yb adsorption, and then the low concentration HCl eluent enters the second separation column 5 to remove the impurities on the second separation column 5 and retain 177 Lu, and then use a higher concentration of HCl desorption liquid to remove the second separation column 5 177 Lu desorption to obtain carrier-free 177 Lu solution, thereby passing through the first separation column 3 and the second separation column 5 from the 177 Lu raw material solution was separated and purified to obtain carrier-free 177 Lu solution.

[0066] In the present application, the feed module 1, the first separation column 3, the second separation column 5, the first reversing valve 2 and the transfer container 4 are used to realize the separation of the containing 177 The two-stage separation of Lu raw material solution and the final high-purity carrier-free 177 Lu solution, the whole operation process is simple and convenient, and the separation effect is good.

[0067] In some embodiments, Figure 1 As shown, a liquid supply pipeline a is connected between the feeding end of the feeding module 1 and the first inlet of the first reversing valve 2, a first branch pipe b is connected between the first outlet of the first reversing valve 2 and the inlet of the first separation column 3, a second branch pipe c is connected between the second outlet of the first reversing valve 2 and the inlet of the second separation column 5, a first connecting pipe d is connected between the inlet of the transfer container 4 and the outlet of the first separation column 3, and a second connecting pipe e is connected between the outlet of the transfer container 4 and the inlet of the second separation column 5. Pipeline connection is convenient for carrier-free 177 The overall layout of Lu solution preparation system 01.

[0068] The first reversing valve 2 may be a long-term stable valve or a disposable replacement valve. When the first reversing valve 2 is a long-term stable valve, the material of the first reversing valve 2 may include polyetheretherketone (PEEK). When the first reversing valve 2 is a disposable replacement valve, the material of the first reversing valve 2 may include polyvinyl chloride (PVC).

[0069] In some examples, such as Figure 1 As shown, a first pump body a1 is arranged on the liquid supply pipeline a, and the first pump body a1 provides power for the supply of the supply module 1 so that the liquid supply pipeline a is provided with a first pump body a1. 177 Lu raw material solution, eluent and desorption solution can flow through the liquid supply pipeline a, the first branch pipe b and the second branch pipe c.

[0070] In some examples, such as Figure 1 As shown, a second pump body e1 is provided on the second connecting pipe e. The second pump body e1 includes 177 The Lu intermediate liquid flows from the outlet of the first separation column 3 to the inlet of the second separation column 5 to provide power.

[0071] The first pump body a1 and the second pump body e1 are peristaltic pumps, and the flow rate and flow rate of the first pump body a1 and the second pump body e1 are controlled by stepping motors (for example, they can be controlled to be adjusted between 0 and 50 ml / min) to ensure the stability of the preparation process. The peristaltic pump can avoid the pump core and the liquid (including 177 Lu raw material solution, eluent, desorption solution or containing 177 Lu intermediate liquid) to avoid damage to the pump core. On this basis, the materials of the liquid supply pipeline a and the second connecting pipe e are both made of high polymer material (BPT) or fluororubber, so that the liquid supply pipeline a and the second connecting pipe e have the characteristics of radiation resistance, acid and alkali resistance, and can facilitate the extrusion of the first pump body a1 and the second pump body e1.

[0072] In addition, the materials of the first branch pipe b, the second branch pipe c, the first connecting pipe d, and the second connecting pipe e include polytetrafluoroethylene (PTFE), and the material is transparent PTFE. Thus, the first branch pipe b, the second branch pipe c, the first connecting pipe d, and the second connecting pipe e have good radiation resistance, acid and alkali resistance.

[0073] In addition, pipe joints are provided at the ends of the liquid supply pipeline a, the first branch pipe b, the second branch pipe c, the first connecting pipe d, and the second connecting pipe e for easy connection. The material of the pipe joints may include PEEK, which has high structural strength and strong sealing performance.

[0074] In some examples, such as Figure 1 As shown, a first one-way valve a2 is provided on the liquid supply pipeline a to prevent the liquid supply pipeline a from 177 The Lu raw material liquid, the eluent and the desorption liquid are refluxed. A second one-way valve b1 is provided on the first branch pipe b to prevent the liquid from entering the first separation column 3 from reflux. A third one-way valve c1 is provided on the second branch pipe c to prevent the liquid from entering the second separation column 5 from reflux. A fourth one-way valve e2 is provided on the second connecting pipe e to prevent the liquid from entering the second separation column 5 from reflux.

[0075] In some embodiments, no carrier 177 The Lu solution preparation system 01 further includes a support module, which includes a housing and a bracket disposed inside the housing, and the first separation column 3, the second separation column 5, and the transfer container 4 are disposed on the support bracket and located inside the housing. The support bracket is used to provide support for the first separation column 3, the second separation column 5, and the transfer container 4, and the housing is used to provide protection.

[0076] The outer shell is made of multiple brushed stainless steel plates, and each steel plate is connected to the bracket by fasteners such as screws to achieve separate disassembly and installation of each steel plate and the bracket.

[0077] In the 177 After the Lu raw material liquid, the eluent and the desorption liquid pass through the first separation column 3 in sequence, not only 177 Lu intermediate liquid, and also produces waste liquids such as permeate and elution waste liquid. 177 After the Lu intermediate liquid, the eluent and the desorption liquid pass through the second separation column 5, not only the carrier-free 177 Lu solution, and waste liquids such as permeate and elution waste liquid are produced, so it is necessary to realize the separation of waste liquid and containing 177 Lu intermediate solution, no carrier 177 The time periods of Lu solution were collected separately.

[0078] Based on this, in the first possible implementation, if Figure 2 As shown, no carrier 177 The Lu solution preparation system 01 also includes a waste liquid container 6, a second reversing valve 7 and a third reversing valve 8. The outlet of the first separation column 3 is connected to the inlet of the transfer container 4 and the waste liquid container 6 through the second reversing valve 7; the first separation column 3 also produces a first waste liquid. When the second reversing valve 7 is in the third state, the outlet of the first separation column 3 is connected to the waste liquid container 6, and the first waste liquid enters the waste liquid container 6. When the second reversing valve 7 is in the fourth state, the outlet of the first separation column 3 is connected to the transfer container 4, and the first waste liquid enters the waste liquid container 6. 177 The Lu intermediate liquid enters the transfer container 4.

[0079] The outlet of the second separation column 5 is connected to the outlet of the separation column 5 for accommodating the carrier-free 177 The Lu solution collection container 9 and the waste liquid container 6 are connected; the second separation column 5 also produces a second waste liquid. When the third reversing valve 8 is in the fifth state, the outlet of the second separation column 5 is connected to the waste liquid container 6, and the second waste liquid enters the waste liquid container 6. When the third reversing valve 8 is in the sixth state, the outlet of the second separation column 5 is connected to the collection container 9, and there is no carrier. 177 The Lu solution enters the collection container 9.

[0080] It can be understood that the type of the second reversing valve 7 can be the same as or different from the type of the first reversing valve 2 , and the type of the third reversing valve 8 can be the same as or different from the type of the first reversing valve 2 .

[0081] It should be explained that the outlet of the first separation column 3 is connected to the inlet of the transfer container 4 and the waste liquid container 6 through the second reversing valve 7, which means that the inlet of the second reversing valve 7 is connected to the outlet of the first separation column 3, the first outlet of the second reversing valve 7 is connected to the inlet of the transfer container 4, and the second outlet of the second reversing valve 7 is connected to the waste liquid container 6.

[0082] The outlet of the second separation column 5 is connected to the outlet of the separation column 5 for accommodating the carrier-free 177 The connection between the Lu solution collection container 9 and the waste liquid container 6 means that the inlet of the third reversing valve 8 is connected to the outlet of the second separation column 5, the first outlet of the third reversing valve 8 is connected to the collection container 9, and the second outlet of the third reversing valve 8 is connected to the waste liquid container 6.

[0083] In some examples, such as Figure 2 As shown, the outlet of the first separation column 3 and the inlet of the second reversing valve 7 are connected by a first conducting pipe 102, the first connecting pipe d is connected between the inlet of the transfer container 4 and the first outlet of the second reversing valve 7, and the third connecting pipe f is connected between the second outlet of the second reversing valve 7 and the waste liquid container 6. 177 The flow of the intermediate liquid in the lumen can also facilitate the spatial layout.

[0084] In some examples, such as Figure 2 As shown, a second conducting pipe 103 is connected between the outlet of the second separation column 5 and the inlet of the third reversing valve 8, a fourth connecting pipe g is connected between the first outlet of the third reversing valve 8 and the collecting container 9, and a fifth connecting pipe h is connected between the second outlet of the third reversing valve 8 and the waste liquid container 6. This makes it easy to separate the second waste liquid and the carrier-free 177 The flow of Lu solution can also facilitate spatial layout.

[0085] In some examples, the waste liquid container 6 can be a 10-liter tank structure, which can facilitate the communication between the waste liquid container 6 and the outlet of the first separation column 3 and the outlet of the second separation column 5. 177 Lu raw material solution is 176 When the Yb target is dissolved in the reactor after being irradiated, the first waste liquid produced by the first separation column 3 and the second waste liquid produced by the second separation column 5 contain fewer types of radioactive impurities, so they can be collected in a waste liquid container 6.

[0086] Through the above arrangement, the second reversing valve 7 can be used to separate the first waste liquid generated by the first separation column 3 and the waste liquid containing 177 Lu intermediate liquid is divided into the waste liquid container 6 and the transfer container 4, so as to facilitate the first waste liquid and the 177 Similarly, the third reversing valve 8 can be used to separate the second waste liquid and the carrier-free liquid generated by the second separation column 5. 177 The Lu solution is divided into the waste liquid container 6 and the collection container 9, so that the second waste liquid and the carrier-free 177 Lu solutions are collected and processed separately.

[0087] In the second possible implementation, Figure 2 As shown, no carrier 177 The Lu solution preparation system 01 also includes a waste liquid container 6 and a second reversing valve 7. The outlet of the first separation column 3 is connected to the inlet of the transfer container 4 and the waste liquid container 6 through the second reversing valve 7. The first separation column 3 also produces a first waste liquid. When the second reversing valve 7 is in the third state, the outlet of the first separation column 3 is connected to the waste liquid container 6, and the first waste liquid enters the waste liquid container 6. When the second reversing valve 7 is in the fourth state, the outlet of the first separation column 3 is connected to the transfer container 4, and the first waste liquid enters the waste liquid container 6. 177 The Lu intermediate liquid enters the transfer container 4.

[0088] Through the above arrangement, the second reversing valve 7 can be used to separate the first waste liquid generated by the first separation column 3 and the waste liquid containing 177 Lu intermediate liquid is divided into the waste liquid container 6 and the transfer container 4, so as to facilitate the first waste liquid and the 177 Collection and treatment of Lu intermediate liquid respectively.

[0089] In a third possible implementation, if Figure 2 As shown, no carrier 177 The Lu solution preparation system 01 further includes a waste liquid container 6 and a third reversing valve 8. The outlet of the second separation column 5 is connected to the outlet of the second separation column 5 through the third reversing valve 8. 177The Lu solution collection container 9 and the waste liquid container 6 are connected; the second separation column 5 also produces a second waste liquid. When the third reversing valve 8 is in the fifth state, the outlet of the second separation column 5 is connected to the waste liquid container 6, and the second waste liquid enters the waste liquid container 6; when the third reversing valve 8 is in the sixth state, the outlet of the second separation column 5 is connected to the collection container 9, and there is no carrier. 177 The Lu solution enters the collection container 9.

[0090] Through the above arrangement, the third reversing valve 8 can be used to separate the second waste liquid and the carrier-free liquid generated by the second separation column 5. 177 The Lu solution is divided into the waste liquid container 6 and the collection container 9, so that the second waste liquid and the carrier-free 177 Lu solutions are collected and processed separately.

[0091] Of course, in other embodiments, one pipeline can also be used to discharge the permeate, the elution waste liquid and the containing liquid in different time periods. 177 Lu intermediate liquid. Similarly, one pipeline can also be used to discharge the permeate, elution waste liquid and non-carrier liquid in different time periods. 177 Lu solution.

[0092] During the preparation process, in order to facilitate monitoring 177 The peak time of Lu radioactivity requires the installation of radioactive detectors at different locations to determine the 177 Lu intermediate liquid and first waste liquid, no carrier 177 The collection time of Lu solution and the second waste liquid respectively.

[0093] Based on this, in the first possible implementation, if Figure 2 , Figure 3 As shown, no carrier 177 The Lu solution preparation system 01 further includes a first radioactivity detector 10 and a second radioactivity detector 101. The first radioactivity detector 10 is disposed between the outlet of the first separation column 3 and the second reversing valve 7, and is used to detect the radioactivity of the solution flowing out of the outlet of the first separation column 3. When the first radioactivity detector 10 detects radioactivity, the second reversing valve 7 switches to the fourth state. The second radioactivity detector 101 is disposed between the outlet of the second separation column 5 and the third reversing valve 8, and is used to detect the radioactivity of the solution flowing out of the outlet of the second separation column 5. When the second radioactivity detector 101 detects radioactivity, the third reversing valve 8 switches to the sixth state.

[0094] It is understandable that the first radioactive detector 10 and the second radioactive detector 101 need to have the characteristics of radiation resistance, long life and wide range, so that they can be better applied in high-radiation environments.

[0095] The radioactivity mainly comes from177 Lu produces 113keV and 208keV gamma rays.

[0096] In some examples, when the first radioactivity detector 10 does not detect radioactivity, the second reversing valve 7 switches to the third state, and the first waste liquid is discharged into the waste liquid container 6 .

[0097] In some examples, when the second radioactivity detector 101 does not detect radioactivity, the third reversing valve 8 switches to the fifth state, and the second waste liquid is discharged into the waste liquid container 6 .

[0098] With the above settings, due to 177 Lu is able to launch γ Therefore, by setting the first radioactive detector 10, when the first radioactive detector 10 detects that the solution flowing out of the outlet of the first separation column 3 is radioactive, it is proved that the solution flowing out of the outlet of the first separation column 3 contains 177 Lu, the second reversing valve 7 can be switched to the fourth state to 177 The Lu intermediate liquid is collected in the transfer container 4. When the first radioactive detector 10 does not detect radioactivity, the second reversing valve 7 is switched to the third state, and the first waste liquid is discharged into the waste liquid container 6. 177 The peak time of the radioactivity of the γ-rays generated by Lu is used to determine the collection of 177 Lu intermediate solution time, so as to achieve 177 Lu intermediate liquid and first waste liquid are collected in different time periods.

[0099] By setting up the second radioactive detector 101, when the second radioactive detector 101 detects that the solution flowing out of the outlet of the second separation column 5 is radioactive, it is proved that the solution flowing out of the outlet of the second separation column 5 contains radioactive 177 Lu, the third reversing valve 8 can be switched to the sixth state to turn the carrier-free 177 The Lu solution is collected in the collection container 9. When the second radioactive detector 101 does not detect radioactivity, the third reversing valve 8 is switched to the fifth state, and the second waste liquid is discharged into the waste liquid container 6. 177 The peak time of the radioactivity of the γ-rays generated by Lu is used to determine the collection of carrier-free 177 Lu solution time, thus achieving carrier-free 177 Lu solution and the second waste liquid are collected at different time periods.

[0100] In the second possible implementation, Figure 3 As shown, no carrier 177The Lu solution preparation system 01 also includes a first radioactivity detector 10, which is arranged between the outlet of the first separation column 3 and the second reversing valve 7, and is used to detect the radioactivity of the solution flowing out from the outlet of the first separation column 3. When the first radioactivity detector 10 detects radioactivity, the second reversing valve 7 switches to the fourth state.

[0101] With the above settings, due to 177 Lu is able to launch γ rays, and γ The radiation is radioactive, so by setting the first radioactive detector 10, when the first radioactive detector 10 detects that the solution flowing out of the outlet of the first separation column 3 is radioactive, it is proved that the solution flowing out of the outlet of the first separation column 3 contains 177 Lu, the second reversing valve 7 can be switched to the fourth state to 177 The Lu intermediate liquid is collected in the transfer container 4. When the first radioactive detector 10 does not detect radioactivity, the second reversing valve 7 is switched to the third state, and the first waste liquid is discharged into the waste liquid container 6. 177 The peak time of the radioactivity of the γ-rays generated by Lu is used to determine the collection of 177 Lu intermediate solution time, so as to achieve 177 Lu intermediate liquid and first waste liquid are collected in different time periods.

[0102] In a third possible implementation, if Figure 3 As shown, no carrier 177 The Lu solution preparation system 01 also includes a second radioactivity detector 101, which is arranged between the outlet of the second separation column 5 and the third reversing valve 8, and is used to detect the radioactivity of the solution flowing out from the outlet of the second separation column 5. When the second radioactivity detector 101 detects radioactivity, the third reversing valve 8 switches to the sixth state.

[0103] By setting up the second radioactive detector 101, when the second radioactive detector 101 detects that the solution flowing out of the outlet of the second separation column 5 is radioactive, it is proved that the solution flowing out of the outlet of the second separation column 5 contains radioactive 177 Lu, the third reversing valve 8 can be switched to the sixth state to turn the carrier-free 177 The Lu solution is collected in the collection container 9. When the second radioactive detector 101 does not detect radioactivity, the third reversing valve 8 is switched to the fifth state, and the second waste liquid is discharged into the waste liquid container 6. 177 The peak time of the radioactivity of the γ-rays generated by Lu is used to determine the collection of carrier-free 177Lu solution time, thus achieving carrier-free 177 Lu solution and the second waste liquid are collected at different time periods.

[0104] On this basis, in some embodiments, such as Figure 3 As shown, a first conducting pipe 102 is connected between the outlet of the first separation column 3 and the inlet of the second reversing valve 7, and the first conducting pipe 102 passes through the shielding channel of the first radioactive detector 10. A second conducting pipe 103 is connected between the outlet of the second separation column 5 and the inlet of the third reversing valve 8, and the second conducting pipe 103 passes through the shielding channel of the second radioactive detector 101.

[0105] It can be understood that the first conducting tube 102 can allow radioactivity to pass through, and the second conducting tube 103 can allow radioactivity to pass through, so that the first radioactivity detector 10 and the second radioactivity detector 101 can detect radioactivity.

[0106] The first conducting tube 102 and the second conducting tube 103 are hoses, and the material thereof may include Teflon.

[0107] By setting the first conducting tube 102, the first conducting tube 102 can connect the outlet of the first separation column 3 with the inlet of the second reversing valve 7, so as to realize the circulation of the solution. Since the first conducting tube 102 passes through the shielding channel of the first radioactive detector 10, it can not only facilitate the detection setting of the first radioactive detector 10, but also ensure the stability of the detection.

[0108] By setting up the second conducting pipe 103, the second conducting pipe 103 can connect the outlet of the second separation column 5 with the inlet of the third reversing valve 8, so as to realize the circulation of the solution. Since the second conducting pipe 103 passes through the shielding channel of the second radioactive detector 101, it can not only facilitate the detection setting of the second radioactive detector 101, but also ensure the stability of the detection.

[0109] In other embodiments, Figure 3 As shown, a first conducting pipe 102 is connected between the outlet of the first separation column 3 and the inlet of the second reversing valve 7 , and the first conducting pipe 102 passes through the shielding channel of the first radioactive detector 10 .

[0110] By setting the first conducting tube 102, the first conducting tube 102 can connect the outlet of the first separation column 3 with the inlet of the second reversing valve 7, so as to realize the circulation of the solution. Since the first conducting tube 102 passes through the shielding channel of the first radioactive detector 10, it can not only facilitate the detection setting of the first radioactive detector 10, but also ensure the stability of the detection.

[0111] In other embodiments, Figure 3As shown, a second conducting pipe 103 is connected between the outlet of the second separation column 5 and the inlet of the third reversing valve 8 , and the second conducting pipe 103 passes through the shielding channel of the second radioactive detector 101 .

[0112] By setting up the second conducting pipe 103, the second conducting pipe 103 can connect the outlet of the second separation column 5 with the inlet of the third reversing valve 8, so as to realize the circulation of the solution. Since the second conducting pipe 103 passes through the shielding channel of the second radioactive detector 101, it can not only facilitate the detection setting of the second radioactive detector 101, but also ensure the stability of the detection.

[0113] Of course, in other embodiments, the first radioactive detector 10 may be attached only to the first conducting tube 102, and the second radioactive detector 101 may be attached only to the second conducting tube 103, so as to realize radioactive detection.

[0114] On this basis, in some embodiments, such as Figure 3 As shown, no carrier 177 The Lu solution preparation system 01 also includes a product container i, the inlet of the product container i is connected to the outlet of the collection container 9. A sixth connecting pipe j is connected between the inlet of the product container i and the collection container 9, and the third pump body k is arranged on the sixth connecting pipe j. In this way, the third pump body k can drive the carrier-free liquid in the collection container 9. 177 Lu solution enters the product container i for subsequent 177 Movement of Lu solution.

[0115] Among them, the product container i can be an ordinary glass bottle.

[0116] In some embodiments, Figure 3 As shown, no carrier 177 The Lu solution preparation system 01 further includes a pressure device 104, and the outlet of the pressure device 104 is connected to the first separation column 3 and the second separation column 5 through the first reversing valve 2. When the first reversing valve 2 is in the first state, the outlet of the pressure device 104 is connected to the inlet of the first separation column 3; and / or, when the first reversing valve 2 is in the second state, the outlet of the pressure device 104 is connected to the inlet of the second separation column 5.

[0117] It can be understood that the outlet of the pressure-applying device 104 is connected to the first separation column 3 and the second separation column 5 via the first reversing valve 2 , which means that the outlet of the pressure-applying device 104 is connected to the second inlet of the first reversing valve 2 .

[0118] Among them, a seventh connecting pipe 1 is connected between the outlet of the pressure-applying device 104 and the second inlet of the second reversing valve 7, so that the connection between the pressure-applying device 104 and the second reversing valve 7 can be facilitated.

[0119] In addition, the pressure applying device 104 may be an air supply pump, which may include 177 The flow of Lu raw material liquid, eluent and desorption liquid provides pressure. The air supply pump can be a plunger pump, and the installation of the plunger pump and the seventh connecting pipe l has a pressing type and a screw locking type, and the installation and disassembly of the two are more convenient.

[0120] Through the above arrangement, when the first reversing valve 2 is in the first state, the outlet of the pressure applying device 104 is connected to the first separation column 3 through the first reversing valve 2, so that the pressure applying device 104 can be a device containing 177 The flow of Lu raw liquid, eluent and desorption liquid provides power, thereby increasing the content 177 And / or, when the first reversing valve 2 is in the second state, the outlet of the pressure device 104 is connected to the second separation column 5 through the first reversing valve 2, so that the pressure device 104 can provide power for the flow of the eluent and the desorption liquid, thereby improving the separation efficiency of the carrier-free 177 Separation efficiency of Lu solution.

[0121] In some embodiments, Figure 4 As shown, the feeding module 1 includes a plurality of containers 11 and a fourth reversing valve 12. The plurality of containers 11 are respectively used to store 177 Lu raw material liquid, eluent and desorption liquid. The multiple inlets of the fourth reversing valve 12 are respectively connected to the multiple containers 11, and the outlet of the fourth reversing valve 12 is connected to the inlet of the first separation column 3 and the inlet of the second separation column 5 through the first reversing valve 2.

[0122] It can be understood that the number of containers 11 should be based on the 177 The types of Lu raw liquid, eluent and desorption liquid are determined.

[0123] For example, 177 The Lu raw material solution occupies a container 11, and the eluent includes water, 0.1 mol / L hydrochloric acid, 1 mol / L NH 4 Cl and 0.3 mol / L hydrochloric acid, the eluent occupies four containers 11, the desorption liquid includes 0.04-0.06 mol / L α-hydroxyisobutyric acid solution and 3-6 mol / L hydrochloric acid, the desorption liquid occupies two containers 11, and a total of seven containers 11 are used.

[0124] The container 11 can be an ordinary glass bottle or the like.

[0125] In addition, the volume of each container 11 can be 10 ml, 15 ml or 20 ml, etc.

[0126] Through the above arrangement, the plurality of containers 11 are respectively used to store 177Lu raw material liquid, eluent and desorption liquid, because multiple containers 11 are connected to the first reversing valve 2 through the fourth reversing valve 12, it is possible to achieve 177 Lu raw material solution, eluent and desorption solution are supplied separately in different time periods, which improves the convenience of system supply.

[0127] In some embodiments, Figure 4 As shown, the feeding module 1 further includes a liquid level detector 13 , which is disposed on the plurality of containers 11 and is used to detect the liquid levels of the liquids in the plurality of containers 11 .

[0128] The liquid level detector 13 may be a contact type or a non-contact type, which may be selected according to specific needs.

[0129] In addition, the number of the liquid level detectors 13 may be consistent with the number of the containers 11 . One container 11 corresponds to one liquid level detector 13 , and one liquid level detector 13 detects the content of the liquid in one container 11 .

[0130] The liquid level in the container 11 is detected by the liquid level detector 13, so as to facilitate the detection of the liquid in the container 11. 177 The reserves of Lu raw material liquid, eluent and desorption liquid are monitored to ensure that the liquid reserves in the container 11 are sufficient to ensure normal and stable preparation.

[0131] In some embodiments, Figure 4 As shown, the preparation system 01 further includes a column oven 105 , and the first separation column 3 and the second separation column 5 are disposed in the column oven 105 .

[0132] There is a fixed column in the column temperature box 105 , and the first separation column 3 and the second separation column 5 can be fixed to the fixed column in the column temperature box 105 by a clamp.

[0133] In addition, the temperature provided by the column oven 105 for the first separation column 3 and the second separation column 5 may be between 30° C. and 60° C., for example, 30° C., 40° C., 50° C. or 60° C. The temperature within this range can ensure the separation efficiency to the greatest extent.

[0134] By setting the column temperature box 105, the column temperature box 105 can not only provide an installation position for the first separation column 3 and the second separation column 5, but also provide a stable temperature for the first separation column 3 and the second separation column 5 during the separation process. When the first separation column 3 and the second separation column 5 are heated to the set temperature, the separation process in the first separation column 3 and the second separation column 5 can be ensured to be carried out stably and quickly, and the separation process can also be improved. 177 Separation effect of Lu.

[0135] In some embodiments, the first separation column 3 is filled with a cation exchange resin; the desorption liquid includes: an α-hydroxyisobutyric acid solution, and when the first reversing valve 2 is in the first state, the α-hydroxyisobutyric acid solution enters the first separation column 3.

[0136] Wherein, the cation exchange resin may be DOWEX 50W X8.

[0137] In addition, the concentration of the α-hydroxyisobutyric acid solution may be 0.04-0.06 mol / L, for example, 0.04 mol / L, 0.045 mol / L, 0.049 mol / L, 0.05 mol / L or 0.06 mol / L.

[0138] Through the above settings, the α-hydroxyisobutyric acid solution can better 177 Lu and matrix elements 176 Yb separation can improve the separation effect of the two.

[0139] In some embodiments, the desorption liquid further includes hydrochloric acid. When the first reversing valve 2 is in the second state, the hydrochloric acid enters the second separation column 5. The second separation column 5 is filled with a phosphoric acid-containing leaching resin, which can adsorb the α-hydroxyisobutyric acid solution. 177 Lu.

[0140] Wherein, the concentration of hydrochloric acid can be 3-6 mol / L.

[0141] In addition, the phosphoric acid-containing leaching resin may be P204 leaching resin, P507 leaching resin, or Ln leaching resin.

[0142] By the above arrangement, higher concentration of hydrochloric acid can be used in desorption 177 Lu, so that α-hydroxyisobutyric acid such organic matter remains on the phosphoric acid-containing leaching resin, thereby preventing α-hydroxyisobutyric acid from entering the carrier-free 177 Lu solution to avoid the use of carrier-free 177 When Lu is used for targeted drug production, α-hydroxyisobutyric acid competes with the drug for labeling to ensure 177 Normal production of Lu drugs.

[0143] In some embodiments of the present application, the carrier-free 177The Lu solution preparation system 01 also includes a controller, which is electrically connected to the first pump body a1, the second pump body e1, the third pump body k, the pressure device 104, the first one-way valve a2, the second one-way valve b1, the third one-way valve c1, the fourth one-way valve e2, the first reversing valve 2, the second reversing valve 7, the third reversing valve 8, the fourth reversing valve 12, the first radioactive detector 10, the second radioactive detector 101, and the liquid level detector 105, and the controller is remotely controlled without carrier 177 The Lu solution preparation system 01 can avoid the operator directly contacting the carrier-free 177 The Lu solution preparation system 01 is in contact with the operator to ensure the safety of the operator.

[0144] It can also facilitate the preparation process 177 Lu raw material solution, eluent, desorption solution, containing 177 The flow rate of the Lu intermediate liquid and the like is monitored, and at the same time, the first radioactive detector 10 and the second radioactive detector 101 are used to monitor the flow rate of the Lu intermediate liquid and the like. 177 The radioactive peak time of Lu is detected to achieve automated separation and preparation.

[0145] In addition, the above data can also be displayed on a computer screen to facilitate observation by operators.

[0146] The above are only preferred embodiments of the present application, and are not intended to limit the patent scope of the present application. Any equivalent structure or equivalent process transformation made using the contents of the present application specification and drawings, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present application.

Claims

1. A carrier-free 177 The system for preparing Lu solution is characterized in that: include: A feeding module, a first reversing valve, a first separation column, a transfer container and a second separation column, wherein the feeding module is used to provide 177 Lu raw material liquid, eluent and desorption liquid; the feeding end of the feeding module is connected to the inlet of the first separation column and the inlet of the second separation column through the first reversing valve; the inlet of the transfer container is connected to the outlet of the first separation column, and the outlet of the transfer container is connected to the inlet of the second separation column; When the first reversing valve is in the first state, the feeding end of the feeding module is connected to the inlet of the first separation column. 177 Lu raw material solution, the eluent and the desorption liquid enter the first separation column in sequence to separate and obtain 177 Lu intermediate solution, and the 177 Lu intermediate liquid enters the transfer container; When the first reversing valve is in the second state, the feed end of the feed module is connected to the inlet of the second separation column. 177 Lu intermediate liquid, the eluent and the desorption liquid enter the second separation column in sequence to separate and obtain the carrier-free 177 Lu solution.

2. The carrier-free method according to claim 1 177 The system for preparing Lu solution is characterized in that: Also includes: Waste containers; a second reversing valve, wherein the outlet of the first separation column is connected to the inlet of the transfer container and the waste liquid container through the second reversing valve; the first separation column also generates a first waste liquid; When the second reversing valve is in the third state, the outlet of the first separation column is connected to the waste liquid container, and the first waste liquid enters the waste liquid container; When the second reversing valve is in the fourth state, the outlet of the first separation column is connected to the transfer container. 177 Lu intermediate liquid enters the transfer container; and / or, The outlet of the second separation column is connected to the outlet of the second separation column through the third reversing valve for accommodating the carrier-free 177 The Lu solution collection container and the waste liquid container are connected; the second separation column also produces a second waste liquid; When the third reversing valve is in the fifth state, the outlet of the second separation column is connected to the waste liquid container, and the second waste liquid enters the waste liquid container; When the third reversing valve is in the sixth state, the outlet of the second separation column is connected to the collection container, and the carrier-free 177 The Lu solution enters the collection container.

3. The carrier-free method according to claim 2 177 The system for preparing Lu solution is characterized in that: Also includes: a first radioactivity detector, disposed between the outlet of the first separation column and the second reversing valve, for detecting radioactivity of the solution flowing out of the outlet of the first separation column, wherein the second reversing valve switches to a fourth state when radioactivity is detected by the first radioactivity detector; and / or The second radioactivity detector is arranged between the outlet of the second separation column and the third reversing valve, and is used to detect the radioactivity of the solution flowing out from the outlet of the second separation column. When the second radioactivity detector detects radioactivity, the third reversing valve switches to the sixth state.

4. The carrier-free method according to claim 3 177 The system for preparing Lu solution is characterized in that: A first conducting pipe is connected between the outlet of the first separation column and the inlet of the second reversing valve, and the first conducting pipe passes through the shielding channel of the first radioactive detector; and / or, A second conducting pipe is connected between the outlet of the second separation column and the inlet of the third reversing valve, and the second conducting pipe passes through the shielding channel of the second radioactive detector.

5. The carrier-free method according to claim 1 177 The system for preparing Lu solution is characterized in that: Also includes: A pressure device, wherein an outlet of the pressure device is connected to the first separation column and the second separation column through the first reversing valve; When the first reversing valve is in the first state, the outlet of the pressure applying device is connected to the inlet of the first separation column; and / or, When the first reversing valve is in the second state, the outlet of the pressure applying device is communicated with the inlet of the second separation column.

6. The carrier-free method according to claim 1 177 The system for preparing Lu solution is characterized in that: The feeding module comprises: A plurality of containers are respectively used to store the 177 Lu raw material solution, the eluent and the desorption liquid; A fourth reversing valve, wherein the plurality of inlets of the fourth reversing valve are respectively connected to the plurality of containers, and the outlet of the fourth reversing valve is connected to the inlet of the first separation column and the inlet of the second separation column through the first reversing valve.

7. The carrier-free method according to claim 6 177 The system for preparing Lu solution is characterized in that: The feeding module further includes: a liquid level detector, which is arranged in the multiple containers and is used to detect the liquid levels of the liquids in the multiple containers.

8. The carrier-free method according to claim 1 177 The system for preparing Lu solution is characterized in that: The preparation system further comprises: a column temperature oven, wherein the first separation column and the second separation column are placed in the column temperature oven.

9. The carrier-free method according to any one of claims 1 to 8. 177 The system for preparing Lu solution is characterized in that: The first separation column is filled with a cation exchange resin; the desorption liquid includes an α-hydroxyisobutyric acid solution, and when the first reversing valve is in a first state, the α-hydroxyisobutyric acid solution enters the first separation column.

10. The carrier-free method according to claim 9 177 The system for preparing Lu solution is characterized in that: The desorption liquid also includes: hydrochloric acid, and when the first reversing valve is in the second state, the hydrochloric acid enters the second separation column; the second separation column is filled with a phosphoric acid-containing leaching resin, and the phosphoric acid-containing leaching resin can absorb the α-hydroxyisobutyric acid solution. 177 Lu.

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