A drug purification device for biopharmaceutical processing
By designing a drug purification equipment including a mixing box, partition and heating box, the problem of uneven heating and reduced efficiency of existing equipment when the amount of drugs is large, and the rapid, convenient and efficient drug purification processing is achieved.
Patent Information
- Application Number
- CN202510300514.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-14
- Publication Date
- 2025-05-27
- Estimated Expiration
- 2045-03-14
AI Technical Summary
When the amount of drugs is high in existing biomedical processing equipment, the workload of a single stirring assembly and heating assembly increases, resulting in uneven heating and reduced efficiency.
A drug purification equipment including a mixing box, a partition and a heating box is designed. The mixing box is equipped with a feed assembly, a rotary storage assembly and a fixed stirring assembly. The rotary storage assembly is rotated relative to the fixed stirring assembly by driving the assembly to achieve full mixing, and the heating efficiency is improved through the multiple rotary storage assembly in the heating box.
It realizes the rapid and convenient drug purification processing, improves mixing and heating efficiency, and avoids the problem of uneven heating.
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Figure CN119793286B_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of biomedical processing, and particularly to a drug purification device for biomedical processing. Background Art
[0002] When processing biomedicines, it is necessary to pretreat raw materials, such as crushing, steaming, pressing, etc., and obtain corresponding liquid medicine materials, and then further purify and process the liquid materials.
[0003] Common purification processes include mixing treatment agents and heating. For example, a drug purification device for biomedical processing with the patent publication number CN222287017U mainly includes an outer cylinder, a sealing cover located at the upper part of the outer cylinder, a placement tray located at the bottom end inside the outer cylinder, a purification cylinder located on the placement tray, and a fixing component arranged outside the outer cylinder. Among them, the fixing component is used to fix purification cylinders of different specifications, and at the same time, it is convenient for workers to disassemble and clean the purification cylinder; a stirring component is arranged on the sealing cover, and a heating component is arranged inside the purification cylinder and is used to heat the medicine inside the purification cylinder.
[0004] The above device can stir and mix drugs and heat them. However, when the above device is in use, all drugs are located in the same purification cylinder. In the case of a large amount of drugs, the workload of a single stirring component and heating component increases, and the contact area between the drugs and the purification cylinder or the heating component is relatively small, resulting in a decrease in the heat conduction efficiency of the purification cylinder or the heating component, and it is easy to have uneven heating and reduced heating efficiency.
[0005] Based on this, the present invention designs a drug purification device for biomedical processing to solve the above problems. Summary of the Invention
[0006] The purpose of the present invention is to provide a drug purification device for biomedical processing to solve the problems raised in the above background art.
[0007] To achieve the above purpose, the present invention provides the following technical solutions:
[0008] A drug purification device for biomedical processing includes a cylindrical mixing tank and a heating tank located at the bottom of the mixing tank. The inner side wall and bottom of the heating tank are respectively provided with a first heater and a second heater, and a drain pipe and a valve are provided on one side of the bottom of the heating tank;
[0009] A circular partition is fixed between the mixing box and the heating box. At the center of the bottom of the partition, there is a lifting component and a horizontal lifting ring plate. Along the circumferential direction of the lifting ring plate, a plurality of rotating material storage components are evenly arranged and rotatably connected. The top ends of the rotating material storage components pass through the partition and extend into the mixing box. At the lower part of the inner cavity of the mixing box, there is a driving component, and the driving component is correspondingly connected to the plurality of rotating material storage components;
[0010] In each rotating material storage component, there is a fixed stirring component. The top end of the fixed stirring component extends out of the rotating material storage component and is fixedly connected to the top of the mixing box through a gas guiding structure, and the top end of the gas guiding structure extends out of the mixing box;
[0011] In the middle of the top of the mixing box, there is a feeding component. Along the circumferential direction of the bottom of the feeding component, a plurality of material dropping ports are evenly arranged, and there is a sealing component in the feeding component. At the upper part of the inner side wall of the heating box, there is a material discharging component, and the bottoms of the plurality of rotating material storage components are correspondingly connected to the material discharging component.
[0012] Preferably, the rotating material storage component includes a storage cylinder rotatably connected to the lifting ring plate. At the center of the bottom surface of the storage cylinder, a vertical central tube is fixed, and there is a discharge port and a valve at one side of the bottom. The top end of the central tube is located in the upper part of the inner cavity of the storage cylinder, and there is a ventilation hole at the center of the top end. The top end of the storage cylinder is fixed with an annular top plate. Along the circumferential direction of the bottom of the annular top plate, a plurality of vertical heat conducting rib plates are evenly fixed. The inner side edges of the heat conducting rib plates are fixedly connected to the outer side wall of the storage cylinder, and the bottom ends are located at the lower part of the outer side wall of the storage cylinder. And the storage cylinder is correspondingly connected to the driving component through the heat conducting rib plates;
[0013] At the position corresponding to each storage cylinder on the partition, there is a rotating ring seat rotatably connected. The storage cylinder is slidably connected in the rotating ring seat. At the position corresponding to each heat conducting rib plate on the inner side wall of the rotating ring seat, there is a sliding groove, and the heat conducting rib plate is slidably connected in the sliding groove. The outer side of the rotating ring seat is fixed with a first gear ring, and a plurality of first gear rings are correspondingly connected to the driving component.
[0014] Preferably, the fixed stirring component includes a fixed tube slidably connected to the outside of the central tube. The top end of the fixed tube is fixedly communicated with the gas guiding structure. The bottom end is close to the bottom of the inner cavity of the storage cylinder and is fixed with an annular sealing plate, and the position of the sealing plate corresponds to the position of the annular top plate. Along the circumferential direction of the outside of the fixed tube, a plurality of stirring plates are evenly fixed, and the outer side edges of the stirring plates are located in the inner hole area of the annular top plate;
[0015] The gas guiding structure includes an annular tube fixed to the top of the inner cavity of the mixing box. The top ends of the plurality of fixed tubes are fixedly communicated with the bottom of the annular tube. The top of the annular tube is fixed with a vertical exhaust pipe, and the top end of the exhaust pipe passes through and extends out of the mixing box.
[0016] Preferably, a circular spring groove is provided at the bottom of the circular top plate corresponding to the position of the sealing plate. A plurality of springs are evenly arranged in the circular groove, and a sealing ring is connected by the bottom ends of the plurality of springs, and the bottom of the sealing ring extends out of the spring groove.
[0017] Preferably, the driving assembly includes a circular boss fixed to the top of the partition plate. A rotating ring plate is rotatably connected to the circular boss. A second gear ring is fixed to the inner side of the rotating ring plate. A plurality of first gear rings are all engaged with the inner side of the second gear ring. A transmission bevel gear ring is fixed to the outer side surface of the rotating ring plate. A driving bevel gear is rotatably connected to the inner side wall of the mixing tank. The driving bevel gear is engaged with the transmission bevel gear ring, and a motor is connected to the outer end of the driving bevel gear.
[0018] Preferably, the feeding assembly includes a feeding cylinder fixed to the center of the top of the mixing tank. The bottom end of the feeding cylinder extends into the mixing tank, and a circular flow dividing groove is fixed to the outer side of the bottom end. A plurality of communication grooves are evenly arranged at the bottom of the outer side wall of the feeding cylinder and are communicated with the inner cavity of the flow dividing groove through the communication grooves. A sealing component is provided at the top end of the flow dividing groove. A plurality of flow dividing pipes are evenly and fixedly communicated along the circumferential direction on the outer side wall. The flow dividing pipes are arranged along the radial direction of the flow dividing groove and correspond to the positions of a plurality of storage cylinders one by one. The outer ends of the flow dividing pipes extend to the tops of the storage cylinders, and a blanking port is provided at the bottom of the outer end corresponding to the inner hole area of the circular top plate.
[0019] Preferably, a fixing block is provided at the outer end of the flow dividing pipe and is fixed to the outer side wall of the fixing pipe through the fixing block. By connecting the fixing block and the fixing pipe, the position stability of the outer end of the flow dividing pipe is improved, and the outer end of the flow dividing pipe is prevented from being suspended.
[0020] Preferably, the sealing component includes a circular sealing plug slidably connected to the upper part of the inner cavity of the flow dividing groove. The top end of the sealing plug extends out of the flow dividing groove and is fixed with a circular spring plate. A plurality of springs are evenly connected between the top of the spring plate and the top of the inner cavity of the mixing tank. The spring plate and the top of the inner cavity of the mixing tank are respectively fixed with a circular first electromagnet and a circular second electromagnet at the relative positions. The first electromagnet and the second electromagnet are electrically connected to a power supply and a switch.
[0021] Preferably, a pre-mixing structure is provided in the feeding cylinder, and the pre-mixing structure includes a rotating shaft rotatably connected to the center of the feeding cylinder. The bottom end of the rotating shaft extends out of the bottom end of the feeding cylinder and is connected with a motor, and a plurality of rotating plates are evenly arranged on the rotating shaft along the circumferential direction.
[0022] Preferably, the blanking assembly includes a blanking annular pipe fixed to the upper part of the inner side wall of the heating box. A discharge pipe is connected to the blanking annular pipe, and one end of the discharge pipe extends out of the heating box. A plurality of vertical rotating pipes are evenly arranged along the circumferential direction on the top of the blanking annular pipe and are rotatably connected. A guide pipe is connected and fixed to one side of the rotating pipe. One end of the guide pipe is located below the discharge port of the storage cylinder and is connected and fixed with a receiving groove. An adjusting gear is fixed to the top end of the rotating pipe. An adjusting gear ring is rotatably connected to the inner side wall of the heating box. A plurality of adjusting gears are all meshed with the adjusting gear ring, and a micro motor is connected to the top end of one of the adjusting gears.
[0023] Preferably, the lifting assembly includes a vertical screw rod rotatably connected to the center of the bottom of the partition plate. The top end of the screw rod extends out of the partition plate and is connected with a motor. An annular support seat is fixed to the center of the inner cavity bottom of the heating box, and the bottom end of the screw rod is rotatably connected in the support seat. A lifting seat is threadedly connected to the upper part of the screw rod. A plurality of inclined connecting frames are evenly fixed along the circumferential direction on the outer side of the lifting seat, and the outer ends of the plurality of connecting frames are fixedly connected with the inner ring side edge of the lifting ring plate.
[0024] Compared with the prior art, the beneficial effects of the present invention are as follows:
[0025] 1. By providing a mixing box, a partition plate and a heating box, and arranging a feeding assembly in the mixing box, a rotating storage assembly and a fixed stirring assembly on the partition plate, and a blanking assembly in the heating box, the present invention continuously feeds, mixes, heats and blanks the material to be purified, making the drug purification process faster and more convenient;
[0026] 2. The present invention drives the plurality of rotating storage assemblies to rotate relative to the fixed stirring assembly through a driving assembly, so that the materials can be fully mixed and stirred, improving the treatment effect;
[0027] 3. By equally dividing the purified material into a plurality of rotating storage assemblies, the processing amount in each rotating storage assembly is reduced. The method of component processing can increase the overall contact area between the liquid material and hot water, thereby improving the heat conduction and heating efficiency. BRIEF DESCRIPTION OF THE DRAWINGS
[0028] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for the description of the embodiments will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.
[0029] Figure 1 It is a schematic structural diagram of the present invention;
[0030] Figure 2 It is an internal structural diagram of the mixing box of the present invention;
[0031] Figure 3 Schematic diagram of the bottom structure of the heating box of the present invention;
[0032] Figure 4 Schematic diagram of the top structure of the storage cylinder of the present invention;
[0033] Figure 5 Schematic diagram of the bottom structure of the storage cylinder of the present invention;
[0034] Figure 6 Schematic diagram of the structure of the feeding cylinder of the present invention;
[0035] Figure 7 is Figure 2 Schematic diagram of the structure at position A in
[0036] Figure 8 is Figure 2 Schematic diagram of the structure at position B in
[0037] Figure 9 is Figure 1 Schematic diagram of the structure at position C in
[0038] Figure 10 is Figure 4 Schematic diagram of the structure at position D in
[0039] Figure 11 Schematic diagram of the position of the heat conduction rib plate of the present invention;
[0040] Figure 12 is Figure 11 Schematic diagram of the structure at position E in
[0041] In the drawings, the list of components represented by each reference numeral is as follows:
[0042] 100 - mixing box, 101 - feeding cylinder, 102 - diversion groove, 103 - communication groove, 104 - diversion pipe, 105 - blanking port, 106 - fixing block, 107 - rotating shaft, 108 - rotating plate;
[0043] 200 - partition board, 201 - rotating ring seat, 202 - first gear ring, 203 - annular boss, 204 - sliding groove;
[0044] 300 - heating box, 301 - screw rod, 302 - lifting seat, 303 - connecting frame, 304 - lifting ring plate, 305 - first heater, 306 - second heater, 307 - support seat;
[0045] 400 - rotating storage assembly, 401 - storage cylinder, 402 - annular top plate, 403 - heat conduction rib plate, 404 - central pipe, 405 - ventilation hole, 406 - spring groove, 407 - sealing ring;
[0046] 500 - Driving component, 501 - Driving bevel gear, 502 - Rotating ring plate, 503 - Second gear ring, 504 - Transmission bevel gear ring;
[0047] 600 - Fixed stirring component, 601 - Exhaust pipe, 602 - Annular pipe, 603 - Fixed pipe, 604 - Stirring plate, 605 - Sealing plate;
[0048] 700 - Sealing component, 701 - Sealing plug, 702 - Spring plate, 703 - First electromagnet, 704 - Second electromagnet;
[0049] 800 - Feeding component, 801 - Feeding annular pipe, 802 - Rotating pipe, 803 - Adjusting gear, 804 - Adjusting gear ring, 805 - Material guiding pipe, 806 - Material receiving groove. Detailed implementation manners
[0050] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.
[0051] Embodiment 1. Please refer to the accompanying drawings. The present invention provides a technical solution:
[0052] A drug purification device for biomedical processing, as Figure 1 shown, includes a cylindrical mixing tank 100 and a heating tank 300 located at the bottom of the mixing tank 100. A first heater 305 and a second heater 306 are respectively provided on the inner side wall and the bottom of the heating tank 300, and a drain pipe and a valve are provided on one side of the bottom of the heating tank 300;
[0053] A circular partition 200 is fixed between the mixing tank 100 and the heating tank 300. A lifting component and a horizontal lifting ring plate 304 are provided at the center of the bottom of the partition 200. A plurality of rotating storage components 400 are uniformly arranged along the circumferential direction on the lifting ring plate 304 and are rotatably connected. The top ends of the rotating storage components 400 pass through the partition 200 and extend into the mixing tank 100. A driving component 500 is provided in the lower part of the inner cavity of the mixing tank 100, and the driving component 500 is correspondingly connected to the plurality of rotating storage components 400;
[0054] A fixed stirring component 600 is provided in each rotating storage component 400. The top end of the fixed stirring component 600 extends out of the rotating storage component 400 and is fixedly connected to the top of the mixing tank 100 through a gas guiding structure, and the top end of the gas guiding structure extends out of the mixing tank 100;
[0055] A feeding component is provided in the middle of the top of the mixing tank 100. A plurality of material dropping openings 105 are evenly arranged along the circumferential direction at the bottom of the feeding component, and a sealing component 700 is arranged in the feeding component. The upper part of the inner side wall of the heating tank 300 is provided with a material discharging component 800, and the bottoms of the plurality of rotating storage components 400 are correspondingly connected to the material discharging component 800.
[0056] When extracting and processing liquid pharmaceutical materials, materials are added to the plurality of rotating storage components 400 in the mixing tank 100 through the feeding component. At the same time, the rotating storage components 400 are rotated relative to the fixed stirring component 600 through the driving component 500, so as to stir and mix the liquid in the rotating storage components 400, so that the liquid and corresponding treatment agents are fully mixed, improving the treatment effect.
[0057] After mixing is completed, the lifting component is used to drive the lifting ring plate 304 to drive the plurality of rotating storage components 400 to move downward, so that the middle and lower parts of the rotating storage components 400 are located in the hot water in the heating tank 300. The hot water is heated by the first heater 305 and the second heater 306. Then, the materials in the rotating storage components are fully heated by the hot water and maintained at a certain temperature condition for reaction and purification treatment. When the rotating storage components 400 are located in the heating tank 300, the plurality of rotating storage components 400 are rotated through the driving component 500 at the same time, so as to be in full contact with the hot water and improve the heating effect.
[0058] When the plurality of rotating storage components 400 are located in the heating tank 300, their tops are located at the bottom of the fixed stirring component 600, and the tops of the rotating storage components 400 are sealed by the bottom of the fixed stirring component 600. Then, the gas generated by heating in the rotating storage components 400 can enter the gas guiding structure in the fixed stirring component 600 for discharge.
[0059] When the mixing and purification treatment is completed, the lifting component and the lifting ring plate 304 drive the plurality of rotating storage components 400 to move upward. Then, the bottom of the rotating storage component 400 is opened, so that the materials therein can be discharged and fall into the material discharging component 800 for discharging. After the discharging is completed, the rotating storage component 400 is sealed for the next feeding and purification treatment.
[0060] In the present invention, the purified materials are equally divided and loaded into the plurality of rotating storage components 400, reducing the processing amount in each rotating storage component 400. Through the cooperation of the rotating storage component 400 and the fixed stirring component 600, the materials in each rotating storage component 400 can be fully mixed and processed. After the rotating storage component 400 enters the heating tank 300, the way of component processing can increase the contact area between the overall liquid material and the hot water, thereby improving the heat conduction and heating efficiency.
[0061] The present invention facilitates the collection and processing by arranging a blanking component 800 to enable centralized blanking of the materials in multiple rotating material storage components 400.
[0062] Among them, as Figure 4 shown, the rotating material storage component 400 includes a storage cylinder 401 rotatably connected to the lifting ring plate 304. A vertical central tube 404 is fixed at the center of the bottom surface of the storage cylinder 401, and a discharge port and a valve are provided on one side of the bottom. The top end of the central tube 404 is located in the upper part of the inner cavity of the storage cylinder 401, and a ventilation hole 405 is provided at the center of the top end. When the storage cylinder 401 and the central tube 404 are lowered into the hot water of the heating box 300, the air pressure inside the central tube 404 is kept consistent with the outside, and the hot water can smoothly enter the central tube 404 to avoid the generation of negative pressure, etc. As Figure 3 shown, a circular top plate 402 is fixed at the top end of the storage cylinder 401. As Figure 11 shown, a plurality of vertical heat conduction rib plates 403 are uniformly fixed along the circumferential direction at the bottom of the circular top plate 402. The inner side edges of the heat conduction rib plates 403 are fixedly connected to the outer side wall of the storage cylinder 401, and the bottom ends are located at the lower part of the outer side wall of the storage cylinder 401. The storage cylinder 401 is correspondingly connected to the driving component 500 through the heat conduction rib plates 403;
[0063] As Figure 2 shown, a rotating ring seat 201 is rotatably connected to the partition plate 200 at the position corresponding to each storage cylinder 401. The storage cylinder 401 is slidably connected to the rotating ring seat 201. As Figure 12 shown, sliding grooves 204 are provided on the inner side wall of the rotating ring seat 201 at the position corresponding to each heat conduction rib plate 403. The heat conduction rib plates 403 are slidably connected to the sliding grooves 204. A first gear ring 202 is fixed on the outer side of the rotating ring seat 201, and a plurality of first gear rings 202 are all correspondingly connected to the driving component 500.
[0064] After the liquid material enters the storage cylinder 401, the driving component 500 is used to rotate a plurality of first gear rings 202. Through the action of the sliding grooves 204 and the heat conduction rib plates 403, the storage cylinder 401 rotates accordingly and rotates relative to the fixed stirring component 600, realizing relative movement and stirring of the liquid material, and improving the stirring and mixing effect;
[0065] When the material is mixed, the lifting component is used to drive the lifting ring plate 304 to drive a plurality of storage cylinders 401 to move downward, so that the outer side wall of the storage cylinder 401, the heat conduction rib plates 403 and the inner side wall of the central tube 404 are all in contact with the hot water, thereby increasing the contact area with the hot water, improving the heating effect and heating speed of the liquid material. The storage cylinder 401 can be rotated by the driving component 500 to make the heat conduction rib plates 403 fully contact with the hot water and improve the heat conduction effect.
[0066] Among them, asFigure 4 , Figure 5 As shown in Figure 5 , the fixed stirring assembly 600 includes a fixed pipe 603 slidably connected to the outside of the central pipe 404. The top end of the fixed pipe 603 is fixedly communicated with the air guiding structure, and the bottom end is close to the bottom of the inner cavity of the storage cylinder 401 and is fixed with an annular sealing plate 605. The position of the sealing plate 605 corresponds to the position of the annular top plate 402. A plurality of stirring plates 604 are fixedly arranged on the outside of the fixed pipe 603 along the circumferential direction, and the outer side edges of the stirring plates 604 are located in the inner hole area of the annular top plate 402;
[0067] As Figure 4 shown in Figure 4 , the air guiding structure includes an annular pipe 602 fixed to the top of the inner cavity of the mixing box 100. The top ends of a plurality of fixed pipes 603 are fixedly communicated with the bottom of the annular pipe 602. A vertical exhaust pipe 601 is fixed to the top of the annular pipe 602, and the top end of the exhaust pipe 601 passes through and extends out of the mixing box 100.
[0068] During the rotation of the storage cylinder 401, the stirring plates 604 rotate relative to the storage cylinder 401 to stir and mix the materials in the storage cylinder 401. When the storage cylinder 401 moves downward for heat treatment, the sealing plate 605 is located at the top of the storage cylinder 401 and contacts the bottom of the annular top plate 402, thereby closing the top of the storage cylinder 401. Then, the gas materials generated by heating in the storage cylinder 401 enter the annular pipe 602 and the exhaust pipe 601 in the air guiding structure through the fixed pipe 603 and are then discharged, preventing the gas from directly entering the mixing box 100.
[0069] Among them, as Figure 8 shown in Figure 8 , the driving assembly 500 includes an annular boss 203 fixed to the top of the partition plate 200. A rotating ring plate 502 is rotatably connected to the annular boss 203. A second gear ring 503 is fixed to the inner side of the rotating ring plate 502. A plurality of first gear rings 202 are all engaged with the inner side of the second gear ring 503. A driving bevel gear ring 504 is fixed to the outer side surface of the rotating ring plate 502. A driving bevel gear 501 is rotatably connected to the inner side wall of the mixing box 100. The driving bevel gear 501 is engaged with the driving bevel gear ring 504, and the outer end of the driving bevel gear 501 is connected with a motor.
[0070] When it is necessary to rotate the storage cylinder 401, the driving bevel gear 501 is rotated by the driving of the motor, and the rotating ring plate 502 and the second gear ring 503 are driven to rotate through the driving bevel gear ring 504. Then, a plurality of first gear rings 202 and the rotating ring seat 201 are driven to rotate. Then, through the action of the sliding groove 204 and the heat conducting rib plate 403, the storage cylinder 401 rotates with the rotating ring seat 201 and rotates relative to the fixed stirring assembly 600, thereby stirring and mixing the materials in the storage cylinder 401.
[0071] Among them, asFigure 9 As shown in the figure, the blanking assembly 800 includes a blanking annular pipe 801 fixed to the upper part of the inner side wall of the heating box 300. A discharge pipe is connected to the blanking annular pipe 801, and one end of the discharge pipe extends out of the heating box 300. A plurality of vertical rotating pipes 802 are evenly arranged along the circumferential direction on the top of the blanking annular pipe 801 and are rotatably connected. A guide pipe 805 is connected and fixed to one side of the rotating pipe 802. One end of the guide pipe 805 is located below the discharge port of the storage cylinder 401 and is connected and fixed with a receiving groove 806. An adjusting gear 803 is fixed to the top end of the rotating pipe 802. An adjusting gear ring 804 is rotatably connected to the inner side wall of the heating box 300. A plurality of adjusting gears 803 are all meshed with the adjusting gear ring 804, and the top end of one of the adjusting gears 803 is connected with a micro motor.
[0072] When structures such as the storage cylinder 401 need to move, through the drive of the micro motor and the transmission of the adjusting gear ring 804 and a plurality of adjusting gears 803, the plurality of rotating pipes 802 rotate simultaneously, and drive the corresponding guide pipes 805 and receiving grooves 806 to rotate, so that the positions of structures such as the receiving groove 806 are staggered from the position of the lifting ring plate 304, avoiding affecting the movement of the lifting ring plate 304 and the structures thereon; after the materials in the storage cylinder 401 are heated and moved back to the original position, through structures such as the micro motor, the rotating pipe 802 drives the guide pipe 805 and the receiving groove 806 to rotate, so that the receiving groove 806 rotates to below the blanking port of the storage cylinder 401, and then the valve of the blanking port is opened, so that the materials in the storage cylinder 401 fall into the receiving groove 806 and enter the blanking annular pipe 801 along the guide pipe 805 and the rotating pipe 802, so as to carry out centralized blanking of the materials in a plurality of storage cylinders 401.
[0073] Embodiment 2. The structure of this embodiment is basically the same as that of Embodiment 1, the difference is that, as Figure 10 shown, an annular spring groove 406 is provided at the bottom of the annular top plate 402 corresponding to the position of the sealing plate 605. A plurality of springs are evenly arranged in the annular groove, and a sealing ring 407 is connected by the bottom ends of the plurality of springs. The bottom of the sealing ring 407 extends out of the spring groove 406. When the sealing plate 605 moves up to contact the bottom of the annular top plate 402, the top surface of the sealing plate 605 contacts the sealing ring 407, and during the rotation of structures such as the annular top plate 402, the top of the sealing plate 605 is kept in contact with the spring and the sealing ring 407, thereby improving the sealing performance of the top of the storage cylinder 401.
[0074] Embodiment 3. The structure of this embodiment is basically the same as that of Embodiment 1, the difference is that, as Figure 6As shown in the figure, the feeding assembly includes a feeding cylinder 101 fixed at the center of the top of the mixing tank 100. The bottom end of the feeding cylinder 101 extends into the mixing tank 100, and an annular diversion groove 102 is fixed on the outer side of the bottom end. A plurality of communication grooves 103 are evenly arranged at the bottom of the outer side wall of the feeding cylinder 101 and communicate with the inner cavity of the diversion groove 102 through the communication grooves 103. A sealing assembly 700 is provided at the top end of the diversion groove 102, and a plurality of diversion pipes 104 are evenly and fixedly connected along the circumferential direction on the outer side wall. The diversion pipes 104 are arranged along the radial direction of the diversion groove 102 and correspond to the positions of a plurality of storage cylinders 401 one by one. As Figure 7 shown, the outer end of the diversion pipe 104 extends to the top of the storage cylinder 401, and a material dropping port 105 is provided at the bottom of the outer side end corresponding to the inner hole area of the annular top plate 402.
[0075] A fixing block 106 is provided at the outer side end of the diversion pipe 104 and is fixed to the outer side wall of the fixing pipe 603 through the fixing block 106. By connecting the fixing block 106 with the fixing pipe 603, the position stability of the outer side end of the diversion pipe 104 is improved, and the outer side end of the diversion pipe 104 is prevented from being suspended.
[0076] When it is necessary to feed materials into a plurality of storage cylinders 401, the diversion groove 102 is opened through the sealing assembly 700, so that the diversion groove 102 communicates with the diversion pipes 104 and the feeding cylinder 101. Thus, the materials put into the feeding cylinder 101 can enter the diversion groove 102 along the communication grooves 103, then enter a plurality of diversion pipes 104, and then flow along the diversion pipes 104 and fall into the corresponding storage cylinders 401 through the material dropping ports 105, realizing the feeding operation of the storage cylinders 401.
[0077] When the feeding operation is completed, the diversion groove 102 is closed through the sealing assembly 700, so that the inner side end of the diversion pipe 104 and the bottom of the feeding cylinder 101 are closed, so as to pause the feeding of the storage cylinder 401 and perform processes such as mixing and heating.
[0078] Among them, as Figure 6 shown, the sealing assembly 700 includes an annular sealing plug 701 slidably connected to the upper part of the inner cavity of the diversion groove 102. The top end of the sealing plug 701 extends out of the diversion groove 102 and is fixed with an annular spring plate 702. A plurality of springs are evenly connected between the top of the spring plate 702 and the top of the inner cavity of the mixing tank 100. Annular first electromagnets 703 and second electromagnets 704 are respectively fixed at the relative positions of the spring plate 702 and the top of the inner cavity of the mixing tank 100. The first electromagnets 703 and the second electromagnets 704 are electrically connected to a power supply and a switch.
[0079] When the shunt trough 102 is working, the bottom end of the sealing plug 701 is located above the shunt trough 102, so that both the communicating trough 103 and the end of the material distribution pipe are communicated with the shunt trough 102. When the feeding assembly pauses feeding, the first electromagnet 703 and the second electromagnet 704 are energized and attracted to each other, stretching the spring by the spring plate 702 and driving the sealing plug 701 to move downward, so that the bottom end of the sealing plug 701 contacts the bottom surface of the shunt trough 102, and the two side walls of the sealing plug 701 contact the two side walls of the shunt trough 102, thereby closing the shunt trough 102 and separating the shunt pipe 104 from the communicating trough 103, achieving the sealing purpose and pausing the feeding into the feeding cylinder 101.
[0080] Embodiment 4. The structure of this embodiment is basically the same as that of Embodiment 1, except that, as Figure 6 shown, a premixing structure is provided in the feeding cylinder 101, and the premixing structure includes a rotating shaft 107 rotatably connected to the center of the feeding cylinder 101. The bottom end of the rotating shaft 107 extends out of the bottom end of the feeding cylinder 101 and is connected to a motor, and a plurality of rotating plates 108 are uniformly arranged on the rotating shaft 107 along the circumferential direction. When liquid materials and the like enter the feeding cylinder 101, the rotating shaft 107 is driven by the motor, and through the rotation of the rotating shaft 107 and the rotating plates 108, the liquid materials and the like are premixed.
[0081] Embodiment 5. The structure of this embodiment is basically the same as that of Embodiment 1, except that, as Figure 2 shown, the lifting assembly includes a vertical screw rod 301 rotatably connected to the center of the bottom of the partition plate 200. The top end of the screw rod 301 extends out of the partition plate 200 and is connected to a motor. As Figure 3 shown, an annular support seat 307 is fixed at the center of the bottom of the inner cavity of the heating box 300, and the bottom end of the screw rod 301 is rotatably connected to the support seat 307. The upper part of the screw rod 301 is threadedly connected with a lifting seat 302. A plurality of inclined connecting frames 303 are uniformly fixed on the outer side of the lifting seat 302 along the circumferential direction, and the outer ends of the plurality of connecting frames 303 are fixedly connected to the inner ring side of the lifting ring plate 304. The lifting ring plate 304 is restricted by the relative movement between the storage cylinder 401 and the partition plate 200 and can only move in the vertical direction. The lifting seat 302 is fixed to the lifting ring plate 304 through the connecting frames 303 and is also subject to the same restriction and guiding effect. Therefore, when the motor drives the screw rod 301 to rotate, the screw rod 301 drives the lifting seat 302 to move in the vertical direction, thereby driving the lifting ring plate 304 and a plurality of storage cylinders 401 to move for mixing and heating treatment.
[0082] In the description of this specification, the descriptions referring to the terms "one embodiment", "example", "specific example", etc. mean that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.
[0083] The preferred embodiments of the present invention disclosed above are only used to help explain the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the present invention to only the specific embodiments. Obviously, according to the content of this specification, many modifications and changes can be made. These embodiments are selected and specifically described in this specification in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can well understand and utilize the present invention. The present invention is only limited by the claims and their full scope and equivalents.
Claims
1. A drug purification device for biopharmaceutical processing, comprising a cylindrical mixing box (100) and a heating box (300) located at the bottom of the mixing box (100), wherein the inner side wall and the bottom of the heating box (300) are respectively provided with a first heater (305) and a second heater (306), and a drainage pipe and a valve are provided on one side of the bottom of the heating box (300), characterized in that: A circular partition (200) is fixed between the mixing box (100) and the heating box (300); a lifting assembly and a horizontal lifting ring plate (304) are provided at the center of the bottom of the partition (200); a plurality of rotating material storage assemblies (400) are evenly arranged and rotatably connected on the lifting ring plate (304) along the circumferential direction; the top of the rotating material storage assembly (400) passes through the partition (200) and extends into the mixing box (100); a driving assembly (500) is provided at the lower part of the inner cavity of the mixing box (100); and the driving assembly (500) is correspondingly connected to the plurality of rotating material storage assemblies (400); Each of the rotating material storage components (400) is provided with a fixed stirring component (600), the top end of the fixed stirring component (600) protrudes from the rotating material storage component (400) and is fixedly connected to the top of the mixing box (100) via an air guide structure, and the top end of the air guide structure protrudes from the mixing box (100); A feeding assembly is provided in the middle of the top of the mixing box (100), a plurality of drop openings (105) are evenly arranged at the bottom of the feeding assembly along the circumferential direction, and a sealing assembly (700) is provided in the feeding assembly, a discharge assembly (800) is provided at the upper part of the inner side wall of the heating box (300), and the bottoms of the plurality of rotating storage assemblies (400) are correspondingly connected to the discharge assembly (800).
2. The drug purification equipment for biopharmaceutical processing according to claim 1, characterized in that: The rotating material storage assembly (400) comprises a material storage barrel (401) rotatably connected to a lifting ring plate (304); a vertical center tube (404) is fixed at the center of the bottom surface of the material storage barrel (401); a discharge port and a valve are provided on one side of the bottom; the top of the center tube (404) is located at the upper part of the inner cavity of the material storage barrel (401); and a vent hole (405) is provided at the center of the top; an annular top plate (402) is fixed at the top of the material storage barrel (401); a plurality of vertical heat-conducting ribs (403) are evenly fixed at the bottom of the annular top plate (402) along the circumferential direction; the inner side edge of the heat-conducting rib (403) is fixedly connected to the outer side wall of the material storage barrel (401); the bottom end is located at the lower part of the outer side wall of the material storage barrel (401); and the material storage barrel (401) is correspondingly connected to the driving assembly (500) via the heat-conducting ribs (403); A rotating ring seat (201) is rotatably connected to a position corresponding to each material storage barrel (401) on the partition (200), and the material storage barrel (401) is slidably connected to the rotating ring seat (201). A sliding groove (204) is provided on the inner side wall of the rotating ring seat (201) at a position corresponding to each heat-conducting rib (403), and the heat-conducting rib (403) is slidably connected to the sliding groove (204). A first gear ring (202) is fixed to the outer side of the rotating ring seat (201), and the plurality of first gear rings (202) are correspondingly connected to the driving assembly (500).
3. The drug purification equipment for biopharmaceutical processing according to claim 2, characterized in that: The fixed stirring assembly (600) comprises a fixed tube (603) slidably connected to the outside of the central tube (404); the top end of the fixed tube (603) is fixedly connected to the air guide structure; the bottom end is close to the bottom of the inner cavity of the storage barrel (401) and is fixed with an annular sealing plate (605); the position of the sealing plate (605) corresponds to the position of the annular top plate (402); a plurality of stirring plates (604) are evenly fixed to the outside of the fixed tube (603) along the circumferential direction; and the outer edges of the stirring plates (604) are located in the inner hole area of the annular top plate (402); The air guide structure comprises an annular tube (602) fixed to the top of the inner cavity of the mixing box (100), the top ends of the plurality of fixed tubes (603) are fixedly connected to the bottom of the annular tube (602), a vertical exhaust pipe (601) is fixed to the top of the annular tube (602), and the top end of the exhaust pipe (601) passes through and protrudes from the mixing box (100).
4. The drug purification equipment for biopharmaceutical processing according to claim 3, characterized in that: An annular spring groove (406) is provided at the bottom of the annular top plate (402) at a position corresponding to the sealing plate (605), a plurality of springs are evenly arranged in the annular groove, and a sealing ring (407) is connected to the bottom ends of the plurality of springs, and the bottom of the sealing ring (407) extends out of the spring groove (406).
5. The drug purification equipment for biopharmaceutical processing according to claim 2, characterized in that: The driving assembly (500) comprises an annular boss (203) fixed to the top of the partition (200); a rotating ring plate (502) is rotatably connected to the annular boss (203); a second gear ring (503) is fixed to the inner side of the rotating ring plate (502); a plurality of first gear rings (202) are meshed with the inner side of the second gear ring (503); a transmission bevel gear ring (504) is fixed to the outer side surface of the rotating ring plate (502); a driving bevel gear (501) is rotatably connected to the inner side wall of the mixing box (100); the driving bevel gear (501) is meshed with the driving bevel gear ring (504); and a motor is connected to the outer end of the driving bevel gear (501).
6. The drug purification equipment for biopharmaceutical processing according to claim 2, characterized in that: The feeding assembly comprises a feeding barrel (101) fixed at the top center of the mixing box (100), the bottom end of the feeding barrel (101) extends into the mixing box (100), and an annular diverter groove (102) is fixed on the outer side of the bottom end, a plurality of connecting grooves (103) are evenly arranged at the bottom of the outer wall of the feeding barrel (101), and are connected with the inner cavity of the diverter groove (102) through the connecting grooves (103), a sealing assembly (700) is arranged at the top of the diverter groove (102), a plurality of diverter pipes (104) are evenly fixed and connected along the circumferential direction on the outer wall, the diverter pipes (104) are arranged along the radial direction of the diverter groove (102), and correspond one by one to the positions of the plurality of storage barrels (401), the outer end of the diverter pipe (104) extends to the top of the storage barrel (401), and a feeding port (105) is arranged at the bottom of the outer end corresponding to the inner hole area of the annular top plate (402).
7. The drug purification equipment for biopharmaceutical processing according to claim 6, characterized in that: The sealing assembly (700) comprises an annular sealing plug (701) slidably connected to the upper part of the inner cavity of the diverter groove (102); the top end of the sealing plug (701) extends out of the diverter groove (102) and is fixed with an annular spring plate (702); a plurality of springs are evenly connected between the top of the spring plate (702) and the top of the inner cavity of the mixing box (100); and an annular first electromagnet (703) and a second electromagnet (704) are respectively fixed at relative positions of the spring plate (702) and the top of the inner cavity of the mixing box (100); the first electromagnet (703) and the second electromagnet (704) are electrically connected to a power supply and a switch.
8. The drug purification equipment for biopharmaceutical processing according to claim 7, characterized in that: The feed barrel (101) is provided with a premixing structure, and the premixing structure comprises a rotating shaft (107) rotatably connected to the center of the feed barrel (101), the bottom end of the rotating shaft (107) protruding from the bottom end of the feed barrel (101) and connected to a motor, and a plurality of rotating plates (108) are evenly arranged on the rotating shaft (107) along the circumferential direction.
9. The drug purification equipment for biopharmaceutical processing according to claim 2, characterized in that: The material discharge assembly (800) comprises a material discharge ring tube (801) fixed to the upper part of the inner wall of the heating box (300), the material discharge ring tube (801) being connected to a material discharge pipe, and one end of the material discharge pipe extending out of the heating box (300), a plurality of vertical rotating tubes (802) being evenly arranged and rotatably connected along the circumferential direction at the top of the material discharge ring tube (801), a material guide tube (805) being connected and fixed to one side of the rotating tube (802), one end of the material guide tube (805) being located below the material discharge port of the material storage barrel (401) and being connected and fixed to a material receiving trough (806), an adjusting gear (803) being fixed to the top of the rotating tube (802), an adjusting gear ring (804) being rotatably connected to the inner wall of the heating box (300), a plurality of adjusting gears (803) being meshed with the adjusting gear ring (804), and a micro motor being connected to the top of one of the adjusting gears (803).
10. The drug purification equipment for biopharmaceutical processing according to any one of claims 1 to 9, characterized in that: The lifting assembly comprises a vertical screw (301) rotatably connected to the center of the bottom of the partition (200), the top end of the screw (301) protrudes from the partition (200) and is connected to a motor, an annular support seat (307) is fixed at the center of the bottom of the inner cavity of the heating box (300), and the bottom end of the screw (301) is rotatably connected to the support seat (307), the upper part of the screw (301) is threadedly connected to a lifting seat (302), and a plurality of inclined connecting frames (303) are evenly fixed to the outer side of the lifting seat (302) along the circumferential direction, and the outer ends of the plurality of connecting frames (303) are fixedly connected to the inner ring side of the lifting ring plate (304).
Citation Information
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