Quantitative sampling device and method for low-boiling-point substances
By using quantitative bodies of parallel quantification pipelines and non-quantitative pipelines in the laboratory, combined with the low-temperature environment and the use of nitrogen or inert gas, the high cost and safety hazards of quantitative injection of low-boiling substances in the prior art are solved, and a high-precision, low-cost and safe quantitative injection effect is achieved.
Patent Information
- Application Number
- CN202510004549.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-02
- Publication Date
- 2025-04-11
AI Technical Summary
The existing mass flow controllers have high costs, easy corrosion, immutable quantitative intervals and experimental safety hazards when dealing with low boiling points, air-sensitive, toxic and harmful substances.
Using a quantitative body including parallel quantitative pipelines and non-quantitative pipelines, the quantitative value changes are achieved by switching valves, combined with the low-temperature environment and the use of nitrogen or inert gas, quantitative injection of low-boiling substances is achieved.
Quantitative injection of low-boiling substances is achieved, which reduces equipment costs, extends service life, increases quantitative accuracy and application scenarios, and improves experimental safety.
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Figure CN119804902A_ABST
Abstract
Description
Technical Field
[0001] The present application relates to the technical field of sample injection control, and in particular to a device and method for quantitatively injecting a low-boiling-point substance. Background Art
[0002] Industrial production involves many parameters, such as temperature, pressure, reaction time, raw material ratio, etc. Through small-scale laboratory experiments, we can systematically study the impact of these parameters on the production process and product quality, find the optimal combination of parameters, thereby improving the quality, output and stability of the product, and provide the best process guidance for industrial production. The input of raw materials, equipment and energy required for small-scale laboratory experiments is relatively small, and the production cost can be estimated and analyzed at an early stage. At the same time, new problems and improvement directions may be discovered during the small-scale test, providing ideas for further optimization of the process.
[0003] In common small-scale laboratory experiments, we often encounter experimental situations that require precise sampling, such as precise liquid volume or gas volume. If the required substances and reaction systems can be exposed to air moisture and the boiling point is greater than room temperature and reaction temperature, direct sampling with a sampling needle can be used. However, with the continuous expansion of scientific research, especially the special properties of materials used in the pharmaceutical and semiconductor industries, air-sensitive, toxic and harmful substances with boiling points below room temperature are often used in laboratories. At this time, to achieve the purpose of precise quantification, relatively expensive mass flow controllers are usually used. However, when using mass flow controllers for quantitative analysis, there may be the following defects: 1. Due to its high precision requirements, complex manufacturing process, versatility and use of high-quality materials, mass flow controllers are usually expensive, and the type of controller usually needs to be changed according to the type of gas, which increases the experimental cost; 2. When a mass flow controller faces corrosive gases, the internal parts of the instrument are easily corroded, and the pipelines are easily blocked. The service life of the controller will be greatly reduced, and the experimental cost will be further increased; 3. Mass flow controllers usually work normally within the calibrated range and cannot accurately output outside the calibrated range. The use conditions are relatively fixed. If a smaller precision or a larger flow rate is required, it is difficult to achieve the purpose. 4. The reactors used in conventional laboratories are glass containers, which are usually not resistant to high pressure. When the mass flow controller delivers low-boiling point substances to the reactor, it is necessary to pay attention to the changes in the pressure in the reactor, and the efficiency of the reactor condensation device is also crucial, otherwise the pressure is too large and the reactor will rupture, resulting in experimental accidents. Summary of the invention
[0004] The present application provides a low-boiling-point substance quantitative sampling device and method, which can relatively simply realize the quantitative sampling of low-boiling-point substances.
[0005] In a first aspect, an embodiment of the present application provides a low-boiling-point substance quantitative injection device, the injection device comprising:
[0006] Feed lines;
[0007] A quantitative body, wherein the quantitative body is connected to the feed pipeline, the quantitative body comprises at least one quantitative unit which is connected to each other, the quantitative unit comprises a quantitative pipeline and a non-quantitative pipeline which are connected in parallel to each other, and a switching valve is provided at the connection point between the quantitative pipeline and the non-quantitative pipeline;
[0008] A discharge pipeline is connected to the quantitative body.
[0009] In the above implementation process, by using quantitative pipelines and non-quantitative pipelines connected in parallel and using a switching valve at the connection point between the two, quantitative injection of low-boiling point substances can be realized relatively simply. At the same time, the quantitative value can be changed by switching the passage of the switching valve, thereby realizing quantitative injection in multiple scenarios. In addition, the quantitative unit in the quantitative body can be replaced separately, which further increases the application scenarios and helps to reduce maintenance costs.
[0010] As an optional embodiment, the feed pipeline is connected to a first liquid accumulation unit; and / or
[0011] The discharge pipeline is connected to a second liquid accumulation unit.
[0012] In the above implementation process, by setting a liquid accumulation unit on the feed pipeline and / or the discharge pipeline, it is beneficial for the material to be injected to form a continuous flow state in the quantitative unit, which is beneficial to the full injection of liquid in the quantitative body and the accurate quantification.
[0013] As an optional embodiment, the quantitative unit includes at least two interconnected quantitative units, and at least one of the quantitative units includes a variable quantitative unit, the quantitative pipeline of the variable quantitative unit is a variable quantitative pipeline, and the maximum quantitative value of the variable quantitative pipeline does not exceed 1mL.
[0014] In the above implementation process, by providing at least one variable quantitative unit in the quantitative body, and the maximum quantitative value of the variable quantitative pipeline does not exceed 1 mL, it is beneficial to improve the quantitative accuracy of the injection device.
[0015] As an optional embodiment, the quantitative unit includes at least two interconnected quantitative units, and the minimum quantitative value of the quantitative pipeline in the quantitative unit is 1mL, and the quantitative values of the quantitative pipeline in the quantitative unit are in an equal multiple series relationship, and the multiple of the equal multiple series is 2.
[0016] In the above implementation process, by adopting quantitative units with quantitative values distributed in equal multiples, it is possible to achieve the effect of covering all quantitative values within a certain range at a lower equipment price.
[0017] In a second aspect, an embodiment of the present application provides a method for quantitatively injecting a low-boiling-point substance, using the injection device provided in the first aspect; the injection method comprises:
[0018] Obtaining a target volume of material to be injected;
[0019] Adjusting the quantitative value of the quantitative body to match the target volume of the substance to be injected;
[0020] Placing the sample injection device after adjusting the quantitative value in a low temperature environment, wherein the temperature of the low temperature environment is between the melting point and the boiling point of the substance to be injected;
[0021] Filling the sample injection device placed in a low-temperature environment with the sample to be injected;
[0022] Discharging the substance to be injected from the injection device filled with the substance to be injected except the substance in the quantitative pipeline, so that the volume value of the substance to be injected in the injection device matches the target volume, thereby obtaining a sample-containing device;
[0023] The material to be injected in the sample-containing device is injected into a reaction container.
[0024] In the above implementation process, the method can relatively simply realize the quantitative injection of low-boiling point substances. The cost of the injection device used is lower than that of the mass flow controller, and the quantitative unit in the quantitative body can be replaced separately, further reducing maintenance costs and helping to increase application scenarios.
[0025] As an optional implementation, the low temperature environment includes an ethylene glycol ice water bath or an ice salt water bath.
[0026] In the above implementation process, the low temperature environment can be selected according to the actual melting point and boiling point of the material to be injected.
[0027] As an optional implementation, before the sample injection device placed in a low-temperature environment is filled with the sample to be injected, the method further includes: exhausting the air in the sample injection device.
[0028] In the above implementation process, the air can be exhausted from the sampling device, so that the sampling device can be suitable for the sampling of air-sensitive substances.
[0029] As an optional implementation, the method of exhausting the air in the sampling device includes replacing it with nitrogen or an inert gas.
[0030] In the above implementation process, the air in the sampling device can be discharged more easily by replacing it with nitrogen or an inert gas.
[0031] As an optional implementation, the method of discharging the substance to be injected from the injection device filled with the substance to be injected except the quantitative pipeline includes purging with nitrogen or an inert gas.
[0032] In the above implementation process, nitrogen or inert gas is used for purging, which can easily realize the discharge of the sampled material.
[0033] As an optional implementation, before sampling, the method further comprises evacuating the sample-containing device and the reaction container.
[0034] In the above implementation process, vacuum treatment is performed before sampling, which can effectively remove impurity gases in the pipeline, protect sensitive raw materials from contamination, and reduce the probability of damage to the reaction container during sampling. BRIEF DESCRIPTION OF THE DRAWINGS
[0035] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.
[0036] Figure 1 Schematic diagram of the structure of the low boiling point substance quantitative injection device provided in the embodiment of the present application Figure 1 ;
[0037] Figure 2 Schematic diagram of the structure of the low boiling point substance quantitative injection device provided in the embodiment of the present application Figure 2 ;
[0038] Figure 3 A schematic diagram of the structure of a large-capacity quantitative device provided in an embodiment of the present application;
[0039] Figure 4 A schematic diagram of the use process of the low-boiling-point substance quantitative injection device provided in an embodiment of the present application;
[0040] Figure 5 A flowchart of the method provided in the embodiment of the present application.
[0041] Icon: 1-feeding pipeline; 11-first liquid accumulation unit; 2-quantitative body; 21-quantitative unit; 211-quantitative pipeline; 212-non-quantitative pipeline; 3-discharging pipeline; 31-second liquid accumulation unit. DETAILED DESCRIPTION
[0042] The embodiments of the present application will be described in detail below in conjunction with the examples, but it will be appreciated by those skilled in the art that the following examples are only used to illustrate the present application and should not be considered as limiting the scope of the present application. In the examples, if specific conditions are not specified, they are carried out according to normal conditions or the conditions recommended by the manufacturer. If the manufacturer is not specified for the reagents or instruments used, they are all conventional products that can be purchased commercially.
[0043] For air-sensitive, toxic and harmful substances with boiling points below room temperature, relatively expensive mass flow controllers are usually used to achieve accurate quantification. However, mass flow controllers are prone to damage, corrosion, and immutable quantitative ranges, making such experiments very expensive.
[0044] The present application intends to provide a low-boiling-point substance quantitative sampling device and method, which can relatively simply realize the quantitative sampling of low-boiling-point substances.
[0045] Figure 1 Figure 2 Schematic diagram of the structure of the low-boiling-point substance quantitative injection device provided in the embodiment of the present application. In the figure, in order to intuitively display the quantitative capacity, the quantitative pipeline volume in the figure represents the quantitative value of a single quantitative unit 21, that is, it includes the capacity of the valve area connected at both ends of the quantitative pipeline 211 and the capacity of the quantitative pipeline 211. Please refer to Figure 1 and Figure 2 The embodiment of the present application provides a low-boiling-point substance quantitative sampling device, the sampling device comprising: a feed pipeline 1, a quantitative body 2 and a discharge pipeline 3, the quantitative body 2 is connected to the feed pipeline 1, the quantitative body 2 comprises at least one interconnected quantitative unit 21, the quantitative unit 21 comprises a quantitative pipeline 211 and a non-quantitative pipeline 212 connected in parallel, and a switching valve is provided at the connection point between the quantitative pipeline 211 and the non-quantitative pipeline 212; the discharge pipeline 3 is connected to the quantitative body 2.
[0046] The sampling device can realize quantitative sampling of low-boiling-point substances relatively simply by using a quantitative pipeline 211 and a non-quantitative pipeline 212 connected in parallel, and using a switching valve at the connection point between the two. At the same time, the quantitative value can be changed by switching the passage of the switching valve, thereby realizing quantitative sampling in multiple scenarios. In addition, the quantitative unit 21 in the quantitative body 2 can be replaced separately, further increasing the application scenarios and helping to reduce maintenance costs.
[0047] The switching valve can be a three-way valve to switch between the quantitative pipeline 211 and the non-quantitative pipeline 212, thereby realizing the selection of the quantitative value. The components (pipes, valves, etc.) in the injection device can be made of corrosion-resistant PFA material, or stainless steel material to reduce the cost of the device, and they need to be fully purged and replaced after use.
[0048] In some embodiments, the feed pipeline 1 is connected to a first liquid accumulation unit 11; the discharge pipeline 3 is connected to a second liquid accumulation unit 31. By providing a liquid accumulation unit on the feed pipeline 1 and / or the discharge pipeline 3, it is possible to facilitate the continuous flow of the sample to be injected in the quantitative unit 21, thereby facilitating the full injection of the liquid in the quantitative body 2 and achieving accurate quantification. The liquid accumulation unit can be specifically a drip pot.
[0049] In some embodiments, the quantitative unit 21 includes at least two interconnected quantitative units 21, and at least one of the quantitative units 21 includes a variable quantitative unit 21, and the quantitative pipeline 211 of the variable quantitative unit 21 is a variable quantitative pipeline 211, and the maximum quantitative value of the variable quantitative pipeline 211 does not exceed 1mL. By setting at least one variable quantitative unit 21 in the quantitative body 2, and the maximum quantitative value of the variable quantitative pipeline 211 does not exceed 1mL, it is beneficial to improve the quantitative accuracy of the injection device.
[0050] In some embodiments, the quantitative unit 21 includes at least two interconnected quantitative units 21, and the minimum quantitative value of the quantitative pipeline 211 in the quantitative unit 21 is 1 mL, and the quantitative values of the quantitative pipeline 211 in the quantitative unit 21 are in an equal multiple series relationship, and the multiple of the equal multiple series is 2. By using the quantitative unit 21 with quantitative values distributed in an equal multiple series, the effect of covering all quantitative values within a certain range is achieved at a lower equipment price.
[0051] For example, see Figure 1 The scheme in the figure adopts quantitative units 21 with quantitative values of xmL (variable quantitative unit 21, x is adjustable volume), 1mL, 2mL, 4mL, 8mL, 16mL to form a quantitative body 2. The quantitative range of this scheme is (x+y)ml, x is the adjustable volume, usually within 1ml, and y is an integer in the range of 1 to 31. If a larger range is required, quantitative units 21 or Cai Yungong large-capacity quantitative units 21 can be further added to increase the upper limit of the quantitative volume. If only thinner tubes such as 1 / 8 inch tubes are used, the length is usually long and inconvenient to use to achieve large capacity. For example, it can be introduced Figure 3The large-capacity constant volume bottle shown can achieve a larger quantitative volume and a smaller resolution while ensuring accuracy. When injecting, it is only necessary to reverse its direction in the vertical direction to complete the injection. For experiments where the accuracy of the substance to be injected is lower than the quantitative accuracy, for example, if 10.6 ml is required to be quantitatively measured, and the quantitative accuracy is 1 ml, the quantitative value of the variable quantitative unit 21 can be adjusted according to the demand, and the quantitative value of the variable quantitative unit 21 can be adjusted to 0.6 ml. The injection operation can be performed by selecting pipelines with quantitative values of xmL, 2mL and 8mL as the passage, and the purpose of quantitatively measuring 10.6 ml can be achieved.
[0052] If the content needs to be fixed in each experiment, the device can be further simplified by using only one quantitative unit 21, such as Figure 2 As shown in the figure, Z is equal to the capacity volume required for quantitative measurement, the device is simpler and the cost is cheaper.
[0053] Figure 5 For a flow chart of the method provided in the embodiment of the present application, please refer to Figure 5 Based on the same inventive concept, an embodiment of the present application also provides a method for quantitative injection of low-boiling-point substances, using the injection device provided above.
[0054] The method is implemented based on the above-mentioned device. The specific content of the device can refer to the above-mentioned embodiment. Since the method adopts part or all of the technical solutions of the above-mentioned embodiment, it at least has all the beneficial effects brought by the technical solutions of the above-mentioned embodiment, which will not be described one by one here.
[0055] In some embodiments, the injection method comprises:
[0056] S1. Obtaining the target volume of the material to be injected;
[0057] Specifically, the liquid density data of the substance to be injected can be queried, and the density change is usually small and can be ignored, and the volume in the liquid state can be calculated according to the required amount of the substance.
[0058] S2. Adjust the quantitative value of the quantitative body 2 to match the target volume of the substance to be injected;
[0059] Specifically, the switching valve is adjusted to connect the quantitative pipeline 211 of the quantitative unit 21 of the desired quantitative value to form a suitable quantitative path. That is, the selection of the quantitative value is achieved by switching the switching valve and the on-off state of the quantitative pipeline 211 and the non-quantitative pipeline 212.
[0060] S3. placing the sample injection device after adjusting the quantitative value in a low temperature environment, wherein the temperature of the low temperature environment is between the melting point and boiling point of the substance to be injected;
[0061] In some embodiments, the low temperature environment includes an ethylene glycol ice water bath or an ice salt water bath. The low temperature environment can be selected according to the actual melting point and boiling point of the material to be injected.
[0062] Specifically, the injection device selects different cooling systems for cooling according to the temperature range required by the material to be injected. For example, an ethylene glycol ice water bath can achieve a cooling environment of -12 degrees Celsius to -78 degrees Celsius, and an ice salt water bath can achieve a cooling environment of 0 degrees Celsius to -51 degrees Celsius.
[0063] S4. Filling the sample to be injected with the injection device placed in a low temperature environment;
[0064] S5. The sample-containing device is filled with the sample-to-be-injected material except the sample-to-be-injected material in the quantitative pipeline 211, so that the volume value of the sample-to-be-injected material in the sample-to-be-injected device matches the target volume, and a sample-containing device is obtained;
[0065] In some embodiments, the method of discharging the sample-to-be-injected material from the sample-to-be-injected device except the quantitative pipeline 211 includes purging with nitrogen or an inert gas. Purging with nitrogen or an inert gas can achieve the discharge of the sample-to-be-injected material in a relatively simple manner.
[0066] S6. Inject the substance to be injected in the sample-containing device into a reaction container.
[0067] Specifically, automatic sampling can be achieved by switching the switching valves in front of the reaction container one by one and partially restoring the quantitative sampling device to room temperature. At the same time, inert gas or nitrogen can also be used in the form of a small flow of gas to assist the quantitative sampling device in sampling.
[0068] This method can relatively easily realize the quantitative injection of low-boiling point substances. The cost of the injection device used is lower than that of the mass flow controller, and the quantitative unit 21 in the quantitative body 2 can be replaced separately, further reducing maintenance costs and helping to increase application scenarios.
[0069] In some embodiments, before the sample to be injected is filled into the injection device placed in a low temperature environment, the method further includes: exhausting the air in the injection device. The operation of exhausting the air from the injection device can be used to make it suitable for the injection of air-sensitive sample to be injected.
[0070] Furthermore, the method of discharging the air in the sampling device includes replacing it with nitrogen or an inert gas. The method of replacing it with nitrogen or an inert gas can realize the discharge of the air in the sampling device in a relatively simple manner.
[0071] In some embodiments, before the injection, the method further comprises evacuating the sample-containing device and the reaction container. The evacuation before the injection can effectively remove impurity gases in the pipeline, protect sensitive raw materials from contamination, and reduce the probability of damage to the reaction container during the injection.
[0072] The present application will be further described below in conjunction with specific embodiments. It should be understood that these embodiments are intended only to illustrate the present application and are not intended to limit the scope of the present application. The experimental methods for which specific conditions are not specified in the following examples are usually measured according to national standards. If there is no corresponding national standard, then the conditions recommended by the manufacturer are followed.
[0073] The following embodiments adopt Figure 4 The quantitative sampling device is connected in the connection mode of , wherein VA, VB, V1, V2, etc. are valve codes, R1 represents the reactor, and a vacuum device is connected between V16 and V17.
[0074] Example 1
[0075] A method for quantitatively injecting a low-boiling-point substance, comprising:
[0076] Step 1, quantitative volume 10.6ml, adjust the first section of the quantitative tube to 0.6ml, then connect the quantitative injection device to the gas line, all valves are in the closed state, as shown in the attached Figure 4 Use nitrogen and a vacuum device to purge and replace the gas path for more than 20 times, and purge the quantitative pipeline and non-quantitative pipeline clean. At this time, the gas path of the entire quantitative injection device is in a nitrogen environment;
[0077] Step 2, close the nitrogen valve VB, and place the quantitative device and reactor R1 in a low temperature environment of ethylene glycol ice water solution (less than -60 degrees Celsius);
[0078] Step 3, according to the quantitative volume of 10.6 ml, open the corresponding switching valve, and make V1, V2, V5, V6, V9, and V10 point to their respective quantitative pipelines in turn. The switching valves of other quantitative pipelines do not need to point to the quantitative pipelines, and the purpose of quantitative 10.6 ml can be achieved by keeping them unchanged;
[0079] Step 4, open V15 and V18, then open the butane valve switch VA, the butane will be liquefied continuously when passing through the drip pot, so that the liquid will accumulate, and the butane can flow out continuously afterwards; after the butane flows continuously through the required quantitative pipeline, point V10, V9, V6, V5, V2, and V1 to the non-quantitative pipeline in turn, and then close the butane cylinder valve VA, at this time the quantitative step is completed;
[0080] Step 5, open the nitrogen valve VB, use nitrogen and cooperate with the vacuum device to purge and replace the gas line for more than 20 times, and purge the pipeline except for the quantitative part. At this time, the excess butane has been eliminated;
[0081] Step 6, close V18, V15, open V13, V14, V16, V17, turn on the vacuum pump, pump the system to negative pressure, and close V14, V16, V17, and V1 after the pressure stabilizes. Then point V10, V9, V6, V5, and V2 to their respective quantitative pipelines in turn. You can open the front nitrogen to blow slowly, and at the same time point V1 to the quantitative pipeline to assist the flow of the liquid at the rear. You can also restore the quantitative device to room temperature to allow the liquid to naturally vaporize, and then flow to the reaction bottle to liquefy again; then close V13 to complete the low-temperature quantitative injection, and then refer to step 1 to purge the entire pipeline again;
[0082] The feed accuracy is verified by weighing the weight change of R1. The module can be disassembled separately for testing. The weight change of R1 is 5.9574g. The sample is set to be injected with 10.6ml butane, and the theoretical mass is 6.13528g, then the accuracy reaches 97.1%.
[0083] Example 2
[0084] The quantitative steps and the injection steps are the same as those in Example 1. The quantitative volume is 5.6 ml of butane, the theoretical mass is 3.24128 g, the test R1 weight change is 3.1525 g, and the accuracy is 97.3%.
[0085] Example 3
[0086] The quantitative steps and the injection steps are the same as those in Example 1. The quantitative volume is 3.2 ml of dichlorosilane, the theoretical mass is 3.904 g, the test R1 weight change is 3.7958 g, and the accuracy is 97.2%.
[0087] It can be seen from Examples 1 to 3 that the quantitative sampling device provided in the embodiments of the present application achieves high-precision quantification while avoiding contact between the quantified substance and the air, providing a feasible way for laboratories to conduct low-cost and high-demand experiments.
[0088] The above description is only a specific embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims
1. A low boiling point substance quantitative sampling device, characterized in that: The sample injection device comprises: Feed lines; A quantitative body, wherein the quantitative body is connected to the feed pipeline, the quantitative body comprises at least one quantitative unit which is connected to each other, the quantitative unit comprises a quantitative pipeline and a non-quantitative pipeline which are connected in parallel to each other, and a switching valve is provided at the connection point between the quantitative pipeline and the non-quantitative pipeline; A discharge pipeline is connected to the quantitative body.
2. The low boiling point substance quantitative injection device according to claim 1, characterized in that: The feed pipeline is connected to a first liquid accumulation unit; and / or The discharge pipeline is connected to a second liquid accumulation unit.
3. The low boiling point substance quantitative injection device according to claim 1, characterized in that: The quantitative unit includes at least two interconnected quantitative units, and at least one of the quantitative units includes a variable quantitative unit. The quantitative pipeline of the variable quantitative unit is a variable quantitative pipeline, and the maximum quantitative value of the variable quantitative pipeline does not exceed 1 mL.
4. The low boiling point substance quantitative injection device according to claim 1, characterized in that: The quantitative unit comprises at least two interconnected quantitative units, and the minimum quantitative value of the quantitative pipeline in the quantitative unit is 1 mL, and the quantitative values of the quantitative pipeline in the quantitative unit are in an equal multiple series relationship, and the multiple of the equal multiple series is 2.
5. A method for quantitative injection of low boiling point substances, characterized in that: The sampling device according to any one of claims 1 to 2 is used; the sampling method comprises: Obtaining a target volume of material to be injected; Adjusting the quantitative value of the quantitative body to match the target volume of the substance to be injected; Placing the sample injection device after adjusting the quantitative value in a low temperature environment, wherein the temperature of the low temperature environment is between the melting point and the boiling point of the substance to be injected; Filling the sample injection device placed in a low-temperature environment with the sample to be injected; Discharging the substance to be injected from the injection device filled with the substance to be injected except the substance in the quantitative pipeline, so that the volume value of the substance to be injected in the injection device matches the target volume, thereby obtaining a sample-containing device; The material to be injected in the sample-containing device is injected into a reaction container.
6. The low boiling point substance quantitative injection method according to claim 5, characterized in that: The low temperature environment includes an ethylene glycol ice water bath or an ice salt water bath.
7. The method for quantitatively injecting low-boiling-point substances according to claim 5, characterized in that: Before the sample injection device placed in a low-temperature environment is filled with the sample to be injected, the method further comprises: exhausting the air in the sample injection device.
8. The method for quantitatively injecting low-boiling-point substances according to claim 7, characterized in that: The method of exhausting the air in the sampling device includes replacing it with nitrogen or inert gas.
9. The method for quantitatively injecting low-boiling-point substances according to claim 5, characterized in that: The method of discharging the substance to be injected from the injection device filled with the substance to be injected except the quantitative pipeline includes purging with nitrogen or inert gas.
10. The method for quantitatively injecting low-boiling-point substances according to claim 5, characterized in that: Before injecting the sample, the method further comprises evacuating the sample-containing device and the reaction container.