Pre-filled locking syringe with integrated cap

Abstract

A pre-filled syringe, the pre-filled syringe comprising: a barrel comprising a proximal end, a distal end, and a sidewall extending between the proximal end and the distal end, the sidewall defining a chamber containing a medical solution; a plunger rod; and a stopper attached to the distal end portion of the plunger rod and movably received in the chamber; and a disinfection cap coupled to the pre-filled syringe.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims priority to Indian Provisional Application No. 202211046843, filed on August 17, 2022, titled “Pre-Filled Lock Syringe with Integrated Cap,” the entire disclosure of which is incorporated herein by reference in its entirety. Technical Field

[0003] The present disclosure relates generally to prefilled syringes and, more particularly, to prefilled syringes for delivering a lock solution to a catheter, wherein the prefilled syringe includes a sterile cap as part of the syringe. Background Art

[0004] Flushing syringes, scrubbing devices, locking syringes and sterilization caps are currently sold as separate products. These products need to be deployed at the bedside until the intravenous catheter needs to be flushed. The use of caps for passive sterilization and maintaining a physical barrier is a recent development that is still gaining use in clinical settings and is often overlooked by clinicians. There is a need in the art to provide a comprehensive solution for medical procedures utilizing catheters that allows for adequate sterilization and catheter flushing and locking. Summary of the invention

[0005] Thus, the present invention provides improved systems, devices, products, apparatus and / or methods for integrating a pre-filled syringe with a sterilization cap.

[0006] According to some non-limiting embodiments or aspects, a prefilled syringe system is provided, comprising: a prefilled syringe comprising: a barrel comprising: a proximal end, a distal end, and a sidewall extending between the proximal end and the distal end, a chamber defined by the sidewall containing a lock solution; a plunger comprising a plunger rod; and a stopper attached to the distal end of the plunger rod and movably received in a chamber of a housing of a syringe body; and a sterilization cap connected to the prefilled syringe.

[0007] According to one embodiment of the present invention, a prefilled syringe comprises: a barrel, the barrel comprising a proximal end, a distal end and a side wall extending between the proximal end and the distal end, the side wall defining a chamber, the chamber containing a medical solution; a plunger rod, the plunger rod having a proximal end and a distal end; a stopper, the stopper being attached to the distal end of the plunger rod and being received in the chamber in a movably manner; and a sterilization cap, the sterilization cap being releasably coupled to the prefilled syringe. The sterilization cap comprises a housing, the interior of which is defined by the housing being configured to hold a sterilization solution.

[0008] In certain configurations, the plunger includes a thumb press at a proximal end of the plunger rod and a socket positioned between the plunger rod and the thumb press of the plunger. The sterilization cap is contained within the socket.

[0009] In other configurations, the plunger further comprises: a thumb press at the proximal end of the plunger rod; and a cap holder comprising a lock and positioned between the plunger rod and the thumb press. The sterilization cap comprises a pin, and the pin is configured to be releasably coupled to the lock so that the cap can be removed from the cap holder.

[0010] In other configurations, the plunger further includes a thumb press at the proximal end of the plunger rod and a cap holder attached to the thumb press, wherein the sterilization cap is received in the cap holder.

[0011] In certain configurations, the barrel may include a flange at a proximal end thereof, the flange including one or more grooves, and wherein the sterilization cap includes a guide configured to be positioned within the one or more grooves to releasably attach the sterilization cap to the prefilled syringe.

[0012] In still other configurations, the sterilization cap includes a ring that includes a snap connection, wherein the ring is configured to be disposed about an outer surface of the barrel to releasably attach the sterilization cap to the prefilled syringe.

[0013] In other configurations, the barrel includes a flange at a proximal end of the barrel, the flange including a slot having one or more openings therein, and wherein the sterilization cap includes a plate including at least one pin, wherein the plate is configured to be positioned within the slot such that the at least one pin is positioned within at least one opening to releasably attach the sterilization cap to the prefilled syringe.

[0014] In certain configurations, the barrel includes a flange at a proximal end of the barrel, the flange having a recess including at least one groove, and wherein the sterilization cap includes at least one rib extending axially on an outer surface of the sterilization cap such that the at least one rib is configured to be positioned within the at least one groove to releasably attach the sterilization cap to the prefilled syringe.

[0015] In other configurations, the barrel includes a flange at the proximal end of the barrel, and wherein the sterilization cap includes a peel film that is heat sealed to the flange to attach the sterilization cap to the prefilled syringe.

[0016] The plunger rod may include an interior volume at a proximal end of the plunger rod, and a thumb press attached to the interior volume by a hinge, wherein the sterilization cap is configured to be positioned within the interior volume of the plunger.

[0017] In certain configurations, the disinfection cap is configured to be releasably attached to an inner surface of the thumb press.

[0018] In other configurations, the pre-filled syringe further includes a tie having a first end and a second end, wherein the first end is attached to the pre-filled syringe and the second end is attached to the sterilization cap.

[0019] In other configurations, the plunger rod includes a thumb press at a proximal end of the plunger rod, wherein the release film of the sterilization cap is attached to the thumb press.

[0020] In still other configurations, the disinfecting solution includes alcohol.

[0021] In certain configurations, the medical solution is an irrigation solution.

[0022] In other configurations, the medical solution is a catheter lock solution.

[0023] In certain configurations, the barrel includes a Luer connector at its distal end.

[0024] In certain configurations, the prefilled syringe further includes a scrubbing device releasably coupled to the luer connector, the scrubbing device including a housing defining an interior configured to retain a disinfecting solution.

[0025] In still other configurations, the disinfecting solution includes alcohol. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Further advantages and details are explained in more detail below with reference to the exemplary embodiments shown in the attached schematic drawings, in which:

[0027] FIG1 is a cross-sectional view of a prior art pre-filled syringe;

[0028] FIG. 2A to FIG. 2D is a side view and partial view of a non-limiting embodiment of a pre-filled syringe as described herein;

[0029] Figure 3A and Figure 3B is a side view and partial view of a non-limiting embodiment of a pre-filled syringe as described herein;

[0030] FIG. 4A to FIG. 4D is a side view and partial view of a non-limiting embodiment of a pre-filled syringe as described herein;

[0031] FIG. 5A to FIG. 5D is a side view and partial view of a non-limiting embodiment of a pre-filled syringe as described herein;

[0032] FIG. 6A to FIG. 6C are perspective, side and partial views of a non-limiting embodiment of a pre-filled syringe as described herein;

[0033] 7A to 7D is a side view and partial view of a non-limiting embodiment of a pre-filled syringe as described herein;

[0034] FIG. 8A to FIG. 8C is a side view and partial view of a non-limiting embodiment of a pre-filled syringe as described herein;

[0035] Fig. 9A and Fig. 9B is a side view and partial view of a non-limiting embodiment of a pre-filled syringe as described herein;

[0036] Fig. 10A is a side view of a non-limiting embodiment of a pre-filled syringe as described herein;

[0037] Fig. 10B is a side view of a non-limiting embodiment of a pre-filled syringe as described herein;

[0038] Fig.11 is a perspective view of a non-limiting embodiment of a pre-filled syringe as described herein;

[0039] Fig.12 is a side view of a non-limiting embodiment of a pre-filled syringe as described herein;

[0040] Fig.13 is a perspective view of a non-limiting embodiment of a pre-filled syringe as described herein. DETAILED DESCRIPTION

[0041] It should be understood that the present disclosure may employ various alternative variations and step sequences, unless expressly specified to the contrary. It should also be understood that the specific devices and processes shown in the drawings and described in the following specification are merely exemplary and non-limiting embodiments or aspects. Therefore, specific dimensions and other physical characteristics associated with the embodiments or aspects disclosed herein should not be considered limiting.

[0042] For the purposes of the following description, the terms "end", "upper", "lower", "right", "left", "vertical", "horizontal", "top", "bottom", "lateral", "longitudinal" and their derivatives shall refer to embodiments or aspects as they are oriented in the accompanying drawings. However, it should be understood that embodiments or aspects may employ various alternative variations and step sequences unless expressly specified to the contrary. It should also be understood that the specific devices and processes shown in the drawings and described in the following description are merely non-limiting exemplary embodiments or aspects. Therefore, specific dimensions and other physical characteristics related to the embodiments or aspects or aspects of the embodiments disclosed herein should not be considered limiting unless otherwise indicated.

[0043] The aspects, parts, elements, structures, actions, steps, functions, instructions and / or the like used herein should not be interpreted as key or necessary unless explicitly described as such. Moreover, as used herein, the articles "one" and "an" are intended to include one or more projects and can be used interchangeably with "one or more" and "at least one". As used in the specification and claims, the singular forms "one", "one" and "the" include plural referents, for example, unless the context clearly stipulates otherwise. In addition, in addition, as used herein, the terms "group" and "group" are intended to include one or more projects (e.g., related projects, unrelated projects, combinations of related and unrelated projects, etc.), and can be used interchangeably with "one or more" or "at least one". In the case of only intending one project, the term "one" or similar language is used. Moreover, as used herein, the terms "have", "have", "contain" etc. are intended to be open terms.

[0044] Improved systems and products for integrating a cap with a prefilled syringe are provided. Embodiments of the present disclosure may include a prefilled syringe and a sterilization cap that is integrated with the prefilled syringe to form a prefilled syringe system. The prefilled syringe system provided herein integrates a cap with a final product for IV (intravenous) line access (e.g., a prefilled locking syringe) and allows easy access to the cap after use of the prefilled syringe while providing a physical barrier to contamination and helping to maintain the sterility of the IV line. The prefilled syringe system provided herein also enhances compliance with the SASH program and maintains all the important features of the prefilled locking syringe, including attachment to the needle hub and interaction with the user's thumb when depressing the plunger rod.

[0045] Referring to FIG. 1 , FIG. 1 is a diagram of a prefilled syringe 10. The prefilled syringe 10 can be formed of various materials known in the art for prefilled syringes. For example, the prefilled syringe 10 can be formed of glass and / or plastic. In some non-limiting embodiments, the prefilled syringe 10 can be formed of polypropylene. In some non-limiting embodiments, the prefilled syringe 10 includes a barrel 12, a plunger rod 14, a stopper 16, and a Luer connector 18. The barrel 12, the plunger rod 14, and the end cap (not shown) can be formed of various materials known for prefilled syringes. For example, the barrel 12, the plunger rod 14, and the end cap can be formed of glass and / or plastic. In some non-limiting embodiments, the barrel 12, the plunger rod 14, and the end cap can be formed of polypropylene. In some non-limiting embodiments, the plunger rod 14 can include a thumb press on the end of the plunger rod 14 opposite to the stopper 16. The barrel 12 and / or the stopper 16 may be coated with a suitable coating known in the art, for example, to reduce interaction between components containing the solution 20 of the pre-filled syringe, to reduce friction between the components.

[0046] In some non-limiting embodiments, the pre-filled syringe 10 contains a medical solution 20. The medical solution 20 may include any solution and / or drug known in the art suitable for delivery with a pre-filled syringe. For example, the pre-filled syringe 10 may contain a drug, a flushing solution for a catheter, and / or a catheter lock solution, including, for example, those described in U.S. Pat. Nos. 9,872,941 and 11,045,589 and / or U.S. Provisional Patent Application No. 63 / 223,191, the disclosures of which are hereby incorporated by reference in their entirety.

[0047] In some non-limiting embodiments, the pre-filled syringe 10 is designed or constructed to reduce or prevent blood from flowing back into the catheter at the end of flushing and / or applying the lock solution as described herein. In some non-limiting embodiments, the pre-filled syringe 10 is constructed so that the plunger rod 14 is shorter than a typical plunger rod so that compression of the stopper 16 is substantially or completely prevented after injecting the lock solution 20. In some non-limiting embodiments, the stopper 16 is designed or constructed so that the nose of the stopper contacts the distal end of the barrel, adjacent to the Luer connector 18, and blocks the opening, preventing a vacuum and thus preventing blood from flowing back into the catheter.

[0048] Reference now FIG. 2A to FIG. 2D, a non-limiting embodiment of a pre-filled syringe 100 is shown. In some non-limiting embodiments, the pre-filled syringe 100 may include a barrel 112, a plunger rod 114, a stopper 116, a Luer connector 118, and a thumb press 120. In some non-limiting embodiments, the pre-filled syringe 100 may be the same as the previously described pre-filled syringe 10, except that the plunger rod 114 may be modified to integrate a cap 150, such as FIG. 2A to FIG. 2D shown.

[0049] In some non-limiting embodiments, the plunger rod 114 can include a socket 124, which is a cutout area of ​​the plunger, located distal to the thumb press 120, which is configured to hold the cap 150. In some non-limiting embodiments, the plunger rod 114 is modified to accommodate the cap 150 along the central axis C. In some non-limiting embodiments, the socket 124 can be semi-circular, such that the socket 124 is open on one side to allow the cap 150 to be removed, and includes a wall on the other side that connects the thumb press 120 to the rest of the plunger rod 114. In some non-limiting embodiments, the socket 124 can include a tapered inlet 126. The tapered inlet 126 can taper inward to hold the cap 150 in the socket 124.

[0050] In some non-limiting embodiments, the prefilled syringe 100 includes a cap 150. The cap 150 can be formed of various materials. For example, the cap 150 can be formed of plastic. In some non-limiting embodiments, the cap 150 can include a peeling film 152. The peeling film 152 can be coupled (e.g., attached, adhered and / or similarly) to the cap 150. In some non-limiting embodiments, the peeling film 152 can seal the internal volume of the cap 150 and prevent contamination of the internal volume of the cap 150. The cap 150 can contain one or more disinfecting solutions in its interior to disinfect the Luer connector on the catheter. In a non-limiting embodiment, the cap 150 includes one or more substrates, such as a porous substrate, impregnated with a disinfecting solution. Suitable disinfecting solutions are known to those skilled in the art and can include various alcohols, such as isopropyl alcohol, such as 70% isopropyl alcohol. The cap 150 can also include threads on its inner surface to allow the cap to be fixed to the Luer connector of the catheter.

[0051] In some non-limiting embodiments, the cap 150 can be positioned within the socket 124 of the plunger rod 114. In some non-limiting embodiments, the cap 150 can be retained within the socket 124 by means of the tapered inlet 126. In some non-limiting embodiments, a release film 152 can protrude radially from the socket 124.

[0052] return Figure 2B and Figure 2CIn some non-limiting embodiments, the cap 150 can be removed from the socket 124 of the plunger rod 114. For example, the peel-off film 152 and / or a flange disposed on the cap 150 can protrude radially from the socket 124 and can be pulled to remove the cap 150 from the socket 124. As described above, once the cap 150 is removed from the socket 124, the cap 150 is ready for use.

[0053] refer to Figure 2D In some non-limiting embodiments, the prefilled syringe 100 may include a scrubbing device 170. The scrubbing device 170 may be coupled (e.g., attached, connected, and / or the like) to the prefilled syringe 100. In some non-limiting embodiments, the scrubbing device 170 may be connected to the prefilled syringe 100 via a Luer connector 118. The scrubbing device may be similar to the cap 150, wherein it may include a substrate, such as a porous substrate, impregnated with a disinfecting solution, wherein such solutions are known to those skilled in the art. In a non-limiting embodiment, the disinfecting solution may be an alcohol, such as isopropyl alcohol, such as 70% isopropyl alcohol. In use, the scrubbing device 170 may be used to disinfect the Luer connector of the catheter before delivering the solution held in the prefilled syringe 110, and the cap 150 may be used to provide durable protection for the catheter after delivery.

[0054] refer to Figure 3A and Figure 3B , a non-limiting embodiment of a pre-filled syringe 200 is shown. In some non-limiting embodiments, the pre-filled syringe 200 may include a barrel 212, a plunger rod 214, a stopper, a Luer connector 218, and a thumb press 220. In some non-limiting embodiments, the pre-filled syringe 200 may be the same as the previously described pre-filled syringe 10, except that the plunger rod 214 may be modified to integrate a cap 250, such as Figure 3A and Figure 3B shown.

[0055] In some non-limiting embodiments, the plunger rod 214 can include a cap retainer 222. For example, the plunger rod 215 can include a cap retainer 222 positioned adjacent to the thumb press 220. In some non-limiting embodiments, the cap retainer 222 can protrude outwardly from the plunger rod 214 and can be shaped to retain the cap 250. In some non-limiting embodiments, the cap retainer 222 can include a lock 224. For example, the cap retainer 222 can include a lock 224 that is configured to receive a locking pin 254 of the cap 250. In some non-limiting embodiments, the lock 224 can be a bayonet lock.

[0056] In some non-limiting embodiments, the prefilled syringe 200 includes a cap 250. In some non-limiting embodiments, the cap 250 can be the same as the cap 150 previously described. In some non-limiting embodiments, the cap 250 can include a pin 254. For example, the cap 250 can include a pin 254 that is configured to couple with the lock 224 of the cap holder 222. In some non-limiting embodiments, the pin 254 can be a bayonet pin. In some non-limiting embodiments, the cap 250 includes a peeling film 252. For example, the peeling film 252 can be the same as the peeling film 152 previously described.

[0057] In some non-limiting embodiments, the cap 250 can be at least partially positioned within the cap holder 222. For example, the cap 250 can be at least partially positioned within the cap holder 222 so that the peel film 252 faces away from the plunger rod 214. In some non-limiting embodiments, the pin 254 of the cap 250 can be coupled to the lock 224 of the plunger rod 214 to secure the cap 250 to the plunger rod 214. For example, the pin 254 of the cap 250 can be coupled to the lock 224 of the plunger rod 214 via a bayonet lock connection. In some non-limiting embodiments, the cap 250 can be removed from the cap holder 222 by separating the pin 254 and the lock 224. For example, the cap 250 can be separated from the cap holder 222 by separating the bayonet connection between the pin 254 and the lock 224. In this example, the pin 254 and the lock 224 can be separated by rotating the cap 250 and then pulling the cap 250 away from the cap holder 222.

[0058] refer to Figure 3B In some non-limiting embodiments, the pre-filled syringe 200 can include a scrubbing device 270, such as a scrubbing device as described above. In some non-limiting embodiments, the scrubbing device 270 can be coupled (e.g., attached, connected, and / or the like) to the pre-filled syringe 200. In some non-limiting embodiments, the scrubbing device 270 can be connected to the pre-filled syringe 210 via a Luer connector 218.

[0059] refer to FIG. 4A to FIG. 4D , a non-limiting embodiment of a pre-filled syringe 300 is shown. In some non-limiting embodiments, the pre-filled syringe 300 can include a barrel 312, a plunger rod 314, a stopper, a Luer connector 318, and a thumb press 320. In some non-limiting embodiments, the pre-filled syringe 300 can be the same as the previously described pre-filled syringe 10, except that the plunger rod 314 can be modified to integrate a cap 350, such as FIG. 4A to FIG. 4D shown.

[0060] In some non-limiting embodiments, the plunger rod 314 may include a cap holder 322. The cap holder 322 may be connected to the plunger rod 314 by a hinge support 324. In some non-limiting embodiments, the hinge support 324 may connect the cap holder 322 to the thumb press 320. In some non-limiting embodiments, the cap holder 322 may include an internal volume configured to hold the cap 350. In some non-limiting embodiments, the cap holder 322 may include at least one sliding groove 326. For example, the cap holder 322 may include at least one sliding groove 326 that extends vertically along the inner surface of the cap holder 322. In some non-limiting embodiments, the cap holder 322 may include at least one bayonet groove 328. For example, the cap holder 322 may include at least one bayonet groove that communicates with the at least one sliding groove 326 and extends horizontally from the bottom of the at least one sliding groove 326 along the inner surface of the cap holder 322. In some non-limiting embodiments, the at least one slide slot 326 and the at least one bayonet slot 328 may be configured to couple to at least one pin 354 of the cap 350 .

[0061] In some non-limiting embodiments, the prefilled syringe 300 includes a cap 350. In some non-limiting embodiments, the cap 350 can be the same as the cap 150 described previously. In some non-limiting embodiments, the cap 350 can include at least one pin 354. For example, the cap 350 can include at least one pin 354 that is configured to be coupled to at least one sliding slot 326 and at least one bayonet slot 328 of the cap holder 322. In some non-limiting embodiments, the cap 350 can be removed from the cap holder 322 by rotating the cap 350 and pulling the cap 350 vertically out of the cap holder 322 so that at least one pin 354 moves through at least one bayonet slot 328 and upward through at least one sliding slot 326. In some non-limiting embodiments, the cap 350 includes a peeling film 352. For example, the peeling film 352 can be the same as the peeling film 152 described previously.

[0062] refer to Figure 4D In some non-limiting embodiments, the pre-filled syringe system 300 can include a scrubbing device 370. In some non-limiting embodiments, the scrubbing device 370 can be the same as the scrubbing device 170 previously described. In some non-limiting embodiments, the scrubbing device 370 can be coupled (e.g., attached, connected, and / or the like) to the pre-filled syringe 310. In some non-limiting embodiments, the scrubbing device 370 can be connected to the pre-filled syringe 300 via a Luer connector 318.

[0063] refer to FIG. 5A to FIG. 5D, a non-limiting embodiment of a pre-filled syringe 400 is shown. In some non-limiting embodiments, the pre-filled syringe 400 includes a barrel 412, a plunger rod 414, a stopper, a Luer connector 418, and a thumb press 420. In some non-limiting embodiments, the pre-filled syringe 400 can be the same as the previously described pre-filled syringe 10, except that the pre-filled syringe 400 includes a modified flange 422, such as FIG. 5A to FIG. 5D shown.

[0064] In some non-limiting embodiments, the flange 422 may include a slot 424. For example, the flange 422 may include a slot 424 extending vertically through the flange 422. In some non-limiting embodiments, the slot 424 may include a "T" shaped cross-section extending vertically through the flange 422. In some non-limiting embodiments, the slot 424 may be configured to be coupled to a guide 454 of the cap 450.

[0065] In some non-limiting embodiments, the prefilled syringe 400 includes a cap 450. In some non-limiting embodiments, the cap 450 can be the same as the cap 150 described previously. In some non-limiting embodiments, the cap 450 can include a guide 454. For example, the cap 450 can include a guide 454 that is attached to an outer surface of the cap 450. In some non-limiting embodiments, the guide 454 can be configured such that it includes a cross-sectional "T" shape (e.g., as shown in FIG. 1 ) formed by the member 453 and the (one or more) protrusions 456. Figure 5C 424). For example, the guide 454 may include a "T" shaped cross section corresponding to the "T" shaped cross section of the groove 424 on the flange 422. In some non-limiting embodiments, the guide 454 may include one or more protrusions 456. For example, the guide 454 may include a protrusion 456 extending from the surface of the member 453. In some non-limiting embodiments, the guide 454 may be configured to be coupled to the groove 424 on the flange 422. For example, the guide 454 may be configured to be coupled to the groove 424 on the flange 422, and the protrusion 456 may help couple the guide 454 to the groove 424 on the flange 422. In some non-limiting embodiments, the cap 450 includes a peeling film 452. For example, the peeling film 452 may be the same as the peeling film 152 described previously.

[0066] refer to Figure 5DIn some non-limiting embodiments, the pre-filled syringe 400 can include a scrubbing device 470. In some non-limiting embodiments, the scrubbing device 470 can be the same as the scrubbing device 170 described previously. In some non-limiting embodiments, the scrubbing device 470 can be coupled (e.g., attached, connected, and / or the like) to the pre-filled syringe 410. In some non-limiting embodiments, the scrubbing device 470 can be connected to the pre-filled syringe 410 via a Luer connector 418.

[0067] refer to FIG. 6A to FIG. 6C , a non-limiting embodiment of a pre-filled syringe 500 is shown. In some non-limiting embodiments, the pre-filled syringe 500 can include a barrel 512, a plunger rod 514, a stopper 516, a luer connector 518, and a thumb press 520. In some non-limiting embodiments, the pre-filled syringe 500 can be the same as the pre-filled syringe 10 previously described.

[0068] In some non-limiting embodiments, the prefilled syringe 500 includes a cap 550. In some non-limiting embodiments, the cap 550 can be the same as the cap 150 described previously. In some non-limiting embodiments, the cap 550 can include a ring 554. For example, the cap 550 can include a ring 554 that is attached to the outer surface of the cap 550, for example, at the proximal end of the cap (opposite to the film 552). In some non-limiting embodiments, the ring 554 can include a snap connection 556. The snap connection 556 can allow the ring 554 to be opened and closed. In some non-limiting embodiments, the cap 550 includes a peeling film 552. For example, the peeling film 552 can be the same as the peeling film 152 described previously.

[0069] In some non-limiting embodiments, the cap 550 can be coupled to the pre-filled syringe 500, such as to the barrel 512. For example, a ring 554 can be positioned around the barrel 512 to couple the cap 550 to the pre-filled syringe 510. In some non-limiting embodiments, the cap 550 can be removed from the pre-filled syringe 510 by opening the snap connection 556 and pulling the cap 550 away from the barrel 512.

[0070] refer to Figure 6C In some non-limiting embodiments, the pre-filled syringe 500 can include a scrubbing device 570. In some non-limiting embodiments, the scrubbing device 570 can be the same as the scrubbing device 170 previously described. In some non-limiting embodiments, the scrubbing device 570 can be coupled (e.g., attached, connected, and / or the like) to the pre-filled syringe 510. In some non-limiting embodiments, the scrubbing device 570 can be connected to the pre-filled syringe 510 via a Luer connector 518.

[0071] refer to 7A to 7D , a non-limiting embodiment of a pre-filled syringe 600 is shown. In some non-limiting embodiments, the pre-filled syringe 600 can include a barrel 612, a plunger rod 614, a stopper, a Luer connector 618, and a thumb press 620. In some non-limiting embodiments, the pre-filled syringe 600 can be the same as the previously described pre-filled syringe 10, except that the pre-filled syringe 600 includes a modified flange 622, such as 7A to 7D shown.

[0072] In some non-limiting embodiments, the flange 622 may include a groove 624. For example, the flange 622 may include a groove 624 configured to receive the plate 654 of the cap 650. In some non-limiting embodiments, the groove 624 may be recessed into the flange 622. In some non-limiting embodiments, the groove 624 may have a square cross-section. In some non-limiting embodiments, the groove 624 may include at least one opening 626. For example, the groove 624 may include at least one opening 626 extending into the flange 622. In some non-limiting embodiments, the groove 624 may include at least one opening 626 corresponding to at least one pin 656 on the plate 654 of the cap 650.

[0073] In some non-limiting embodiments, the pre-filled syringe system 600 includes a cap 650. In some non-limiting embodiments, the cap 650 can be the same as the cap 150 described previously. In some non-limiting embodiments, the cap 650 includes a peeling film 652. For example, the peeling film 652 can be the same as the peeling film 152 described previously. In some non-limiting embodiments, the cap 650 can include a plate 654. For example, the cap 650 can include a plate 654 that is attached to the outer surface of the cap 650, for example, on the proximal end of the cap (e.g., opposite to the film 652). In some non-limiting embodiments, the plate 654 can include at least one pin 656. For example, the plate 654 can include at least one pin 656 protruding from the surface of the plate 654. In some non-limiting embodiments, the plate 654 can include at least one pin 656 that corresponds to at least one hole 626 of the groove 624 of the flange 622. In some non-limiting embodiments, the cap 650 can be coupled to the pre-filled syringe 610. For example, the cap 650 can be coupled to the prefilled syringe 610 by inserting the at least one pin 656 into the at least one hole 626, and optionally inserting the plate 654 into the slot 624 by interference and / or press fit. In some non-limiting embodiments, the at least one pin 656 and the at least one hole 626 can form a press fit where the diameter of the hole 626 is slightly smaller than the outer diameter of the at least one pin 656. In some non-limiting embodiments, the cap 650 can be removed from the prefilled syringe 600 by pulling the cap 650 away from the prefilled syringe 600 so that the at least one pin 656 is pulled out of the at least one hole 626 and the plate 654 is pulled out of the slot 624.

[0074] refer to Fig.7D In some non-limiting embodiments, the pre-filled syringe 600 can include a scrubbing device 670. In some non-limiting embodiments, the scrubbing device 670 can be the same as the scrubbing device 170 described previously. In some non-limiting embodiments, the scrubbing device 670 can be coupled (e.g., attached, connected, and / or the like) to the pre-filled syringe 610. In some non-limiting embodiments, the scrubbing device 670 can be connected to the pre-filled syringe 610 via a Luer connector 618.

[0075] refer to FIG. 8A to FIG. 8C , a non-limiting embodiment of a pre-filled syringe 700 is shown. In some non-limiting embodiments, the pre-filled syringe 700 can include a barrel 712, a plunger rod 714, a stopper, a Luer connector 718, and a thumb press 720. In some non-limiting embodiments, the pre-filled syringe 700 can be the same as the previously described pre-filled syringe 10, except that the pre-filled syringe 700 includes a modified flange 722, such as FIG. 8A to FIG. 8C shown.

[0076] In some non-limiting embodiments, the flange 722 can include a recess 724. For example, the flange 722 can include a recess 724 that is a cutout portion of the flange 722. In some non-limiting embodiments, the recess 724 can be a semicircular cutout of the flange 722. In some non-limiting embodiments, the recess 724 can include at least one groove 726 that is arranged around the cutout and / or extends radially, such as Figure 8B For example, the recess 724 may include at least one groove 726 extending into the flange 722 along a cutout portion of the flange 722. In some non-limiting embodiments, the recess 724 may include at least one groove 726 that corresponds to at least one rib 754 of the cap 750.

[0077] In some non-limiting embodiments, the prefilled syringe 700 includes a cap 750. In some non-limiting embodiments, the cap 750 may be the same as the cap 150 described previously. In some non-limiting embodiments, the cap 750 includes a peeling film 752. For example, the peeling film 752 may be the same as the peeling film 152 described previously. In some non-limiting embodiments, the cap 750 may include at least one rib 754. For example, the cap 750 may include at least one rib 754 on the outer surface of the cap 750. In some non-limiting embodiments, the at least one rib 754 may be on the outer surface of the cap 750 and in the axial direction. In some non-limiting embodiments, the at least one rib 754 may correspond to the at least one groove 726 of the recess 724. For example, the at least one rib 754 may be configured to be coupled to the at least one groove 726 of the recess 724. In some non-limiting embodiments, by coupling the at least one rib 754 to the at least one groove 726 of the recess 724, the cap 750 may be coupled to the prefilled syringe 700. In some non-limiting embodiments, the cap 750 may be removed from the pre-filled syringe 700 by pulling the cap 750 away from the pre-filled syringe 700 such that the at least one rib 754 is removed from the at least one groove 726 .

[0078] In some non-limiting embodiments, the pre-filled syringe 700 can include a scrubbing device 770. In some non-limiting embodiments, the scrubbing device 770 can be the same as the previously described scrubbing device 170. In some non-limiting embodiments, the scrubbing device 770 can be coupled (e.g., attached, connected, and / or the like) to the pre-filled syringe 70. In some non-limiting embodiments, the scrubbing device 770 can be connected to the pre-filled syringe 710 via a Luer connector 718.

[0079] refer to Fig. 9A and Fig. 9B, a non-limiting embodiment of a pre-filled syringe 800 is shown. In some non-limiting embodiments, the pre-filled syringe 800 can include a barrel 812, a plunger rod 814, a stopper, a luer connector 818, and a thumb press 820. In some non-limiting embodiments, the pre-filled syringe 810 can be the same as the pre-filled syringe 10 previously described.

[0080] In some non-limiting embodiments, the prefilled syringe 800 includes a cap 850. In some non-limiting embodiments, the cap 850 can be the same as the cap 150 described previously. In some non-limiting embodiments, the cap 850 includes a peeling film 852. For example, the peeling film 852 can be the same as the peeling film 152 described previously. In some non-limiting embodiments, the peeling film 852 can be formed of a heat-sealable material. A "heat-sealable" material refers to a material that can be heated and applied to a substrate so that a seal is formed with the substrate when the material cools. In some non-limiting embodiments, the cap 850 can be coupled to the prefilled syringe 800. For example, the cap 850 can be coupled to the prefilled syringe 800 by heat-sealing the peeling film 852 to the flange 822. In some non-limiting embodiments, the cap 850 can be removed from the prefilled syringe 800 (e.g., flange 822) by pulling the cap 850 away from the prefilled syringe 800 and breaking the heat seal between the peeling film 852 and the flange 822.

[0081] refer to Fig. 9B In some non-limiting embodiments, the pre-filled syringe 800 can include a scrubbing device 870. In some non-limiting embodiments, the scrubbing device 870 can be the same as the scrubbing device 170 described previously. In some non-limiting embodiments, the scrubbing device 870 can be coupled (e.g., attached, connected, and / or the like) to the pre-filled syringe 800. In some non-limiting embodiments, the scrubbing device 870 can be connected to the pre-filled syringe 800 via a Luer connector 818.

[0082] refer to Fig. 10A and Fig. 10B , a non-limiting embodiment of a pre-filled syringe 900 is shown. In some non-limiting embodiments, the pre-filled syringe 900 may include a barrel 912, a plunger rod 914, a stopper 916, a Luer connector 918, and a thumb press 920. In some non-limiting embodiments, the pre-filled syringe 900 may be the same as the previously described pre-filled syringe 10, except that the plunger rod 914 and the thumb press 920 may be similar to the pre-filled syringe 10 described above. Fig. 10A Modified as shown.

[0083] In some non-limiting embodiments, the plunger rod 914 can include an interior volume 924. For example, the plunger rod 914 can include an interior volume 924 configured to hold the cap 950. In some non-limiting embodiments, the plunger rod 914 can include a thumb press 920 attached to the plunger rod 914 via a hinge 922. For example, the plunger rod 914 can include a thumb press 920 attached to the plunger rod 914 via a hinge 922 and configured to couple to the plunger rod 914 to seal the interior volume 924 of the plunger rod 914.

[0084] In some non-limiting embodiments, the pre-filled syringe system 900 includes a cap 950. In some non-limiting embodiments, the cap 950 can be the same as the cap 150 previously described. In some non-limiting embodiments, the cap 950 can be optionally contained within the interior volume 924 of the plunger rod 914 at the proximal end of the plunger rod. For example, the cap 950 can be contained within the interior volume 924 of the plunger rod 914 and sealed within the interior volume 924 by the connection (e.g., hinged connection, snap connection, friction fit, etc.) of the thumb press 920 and the plunger rod 914. In some non-limiting embodiments, the cap 950 can be removed from the pre-filled syringe 900 by opening the thumb press 920 and separating the thumb press 920 from the plunger rod 914 so that the cap 950 can be removed from the interior volume 924 of the plunger rod 914.

[0085] In some non-limiting embodiments, Fig. 10B As shown, the pre-filled syringe 900 may include a housing unit 926 on the plunger rod 914, the housing unit optionally being at the proximal end of the plunger rod as a Fig. 10AIn some non-limiting embodiments, the housing unit 926 may include at least one press-fit joint 928. For example, the housing unit 926 may include two press-fit joints 928 or even more. In some non-limiting embodiments, the housing unit 926 may include a cap cover 930. The cap cover 930 may include at least one press-fit joint groove on the inner surface of the cap cover 930. In some non-limiting embodiments, the at least one press-fit joint groove of the cap cover 930 may be configured to couple with at least one press-fit joint 928. For example, the number of press-fit joint grooves of the cap cover 930 may correspond to the number of press-fit joints 928. In some non-limiting embodiments, the cap 950 may be included in the housing unit 926 of the plunger rod 914. For example, the cap 950 may be included in the housing unit 926 of the plunger rod 914 and sealed in the housing unit 926 by coupling at least one press-fit joint groove of the cap cover 930 with at least one press-fit joint 928. In some non-limiting embodiments, the cap 950 can be removed from the prefilled syringe 900 by pressing at least one press-fit connector 928 to remove at least one press-fit connector groove of the cap cover 930 and separating the cap cover 930 from the housing unit 926 so that the cap 950 can be removed from the housing unit 926.

[0086] In some non-limiting embodiments, the pre-filled syringe 900 can include a scrubbing device. In some non-limiting embodiments, the scrubbing device can be the same as the previously described scrubbing device 170. In some non-limiting embodiments, the scrubbing device can be coupled (e.g., attached, connected, and / or the like) to the pre-filled syringe 900. In some non-limiting embodiments, the scrubbing device can be connected to the pre-filled syringe 900 via a Luer connector.

[0087] refer to Fig.11 , a non-limiting embodiment of a pre-filled syringe 1000 is shown. In some non-limiting embodiments, the pre-filled syringe 1000 may include a barrel 1012, a plunger rod 1014, a stopper, a Luer connector 1018, and a thumb press 1020. In some non-limiting embodiments, the pre-filled syringe 1010 may be the same as the previously described pre-filled syringe 10, except that the plunger rod 1014 and the thumb press 1020 may be similar to the pre-filled syringe 1012. Fig.11 Modified as shown.

[0088] In some non-limiting embodiments, the plunger rod 1014 can include an interior volume 1024 optionally disposed at a proximal end thereof. For example, the plunger rod 1014 can include an interior volume 1024 configured to hold the cap 1050. In some non-limiting embodiments, the plunger rod 1014 can include a thumb press 1020 attached to the plunger rod 1014 via a hinge 1022. For example, the plunger rod 1014 can include a thumb press 1020 attached to the plunger rod 1014 via a hinge 1022 and configured to be coupled to the plunger rod 1014 to seal the interior volume 1024 of the plunger rod 1014.

[0089] In some non-limiting embodiments, the prefilled syringe 1000 includes a cap 1050. In some non-limiting embodiments, the cap 1050 can be the same as the cap 150 previously described. In some non-limiting embodiments, the cap 1050 can be contained within the interior volume 1024 of the plunger rod 1014. For example, the cap 1050 can be contained within the interior volume 1024 of the plunger rod 1014 by the coupling of the thumb press 1020 and the plunger rod 1014 and sealed within the interior volume 1024. In some non-limiting embodiments, the cap 1050 can be coupled to the thumb press 1020. For example, the cap 1050 can be coupled (e.g., attached) to the inner surface of the thumb press 1020 so that when the thumb press 1020 is closed and coupled to the plunger rod 1014, the cap 1050 is contained within the interior volume 1024 of the plunger rod 1014. In some non-limiting embodiments, the cap 1050 can be removed from the prefilled syringe 1010 by opening the thumb press 1020 and separating the thumb press 1020 from the plunger rod 1014 so that the cap 1050 can be removed from the interior volume 1024 of the plunger rod 1014. In such embodiments, when the thumb press 1020 is separated from the plunger rod 1014 to open the interior volume 1024, the cap 1050 attached to the inner surface of the thumb press 1020 is removed from the interior volume 1024 of the plunger rod 1014.

[0090] In some non-limiting embodiments, the pre-filled syringe 1000 can include a scrubbing device. In some non-limiting embodiments, the scrubbing device can be the same as the previously described scrubbing device 170. In some non-limiting embodiments, the scrubbing device can be coupled (e.g., attached, connected, and / or the like) to the pre-filled syringe 1010. In some non-limiting embodiments, the scrubbing device can be connected to the pre-filled syringe 1010 via a Luer connector 1018.

[0091] refer to Fig.12, a non-limiting embodiment of a pre-filled syringe 1100 is shown. In some non-limiting embodiments, the pre-filled syringe 1100 may include a barrel 1112, a plunger rod 1114, a stopper, a luer connector 1118, and a thumb press 1120. In some non-limiting embodiments, the pre-filled syringe 1100 may be the same as the pre-filled syringe 10 previously described.

[0092] In some non-limiting embodiments, the pre-filled syringe system 1100 includes a cap 1150. In some non-limiting embodiments, the cap 1150 can be the same as the cap 150 previously described.

[0093] In some non-limiting embodiments, the cap 1150 can be coupled to the prefilled syringe 1110, for example, to the barrel 1112. For example, the cap 1150 can be coupled to the prefilled syringe 1100, for example, to the barrel 1112, by a lacing device 1122. In some non-limiting embodiments, the lacing device 1122 can include a first lacing loop 1124. The first lacing loop 1124 can be positioned around the outer surface of the barrel 1112 to couple the lacing device 1122 to the barrel 1112. In some non-limiting embodiments, the first lacing loop 1124 can form a portion of the barrel 1112. In some non-limiting embodiments, the first lacing loop 11244 can be removable from the barrel 1112. In some non-limiting embodiments, the lacing device 1122 can include an elongated portion 1126. For example, the lacing device 1122 can include an elongated portion 1126 that attaches the first lacing loop 1124 to the second lacing loop 1128. In some non-limiting embodiments, the lacing device 1124 may include a second lacing loop 1128. In some non-limiting embodiments, the cap 1150 may be coupled to the second lacing loop 1126. For example, the cap 1150 may be attached (e.g., adhered and / or the like) to the second lacing loop 1126. In some non-limiting embodiments, the cap 1150 may be removed from the pre-filled syringe 1100 by removing (e.g., by pulling and / or the like) the cap 1150 from the lacing device 1122. For example, the cap 1150 may be removed from the pre-filled syringe 1100 by removing (e.g., by pulling and / or the like) the cap 1150 from the second lacing loop 1128. In some non-limiting embodiments, the cap 1150 may be removed from the pre-filled syringe system 1100 by removing the lacing device 1122 from the barrel 1112 and then removing the cap 1150 from the lacing device 1122. For example, the cap 1150 may be removed from the pre-filled syringe 1100 by removing the lacing device 1122 from the barrel 1112 and then removing the cap 1150 from the second lacing loop 1128 .

[0094] In some non-limiting embodiments, the pre-filled syringe 1100 can include a scrubbing device. In some non-limiting embodiments, the scrubbing device can be the same as the previously described scrubbing device 170. In some non-limiting embodiments, the scrubbing device can be coupled (e.g., attached, connected, and / or the like) to the pre-filled syringe 1100. In some non-limiting embodiments, the scrubbing device can be connected to the pre-filled syringe 1100 via a Luer connector 1118.

[0095] refer to Fig.13 , shown is a non-limiting embodiment of a pre-filled syringe 1200. In some non-limiting embodiments, the pre-filled syringe 1200 may include a barrel 1212, a plunger rod 1214, a stopper, a luer connector 1218, and a thumb press 1220. In some non-limiting embodiments, the pre-filled syringe 1210 may be the same as the pre-filled syringe 10 previously described.

[0096] In some non-limiting embodiments, the prefilled syringe system 1200 includes a cap 1250. In some non-limiting embodiments, the cap 1250 can be the same as the previously described cap 150. In some non-limiting embodiments, the cap 1250 includes a peel-off film 1252. For example, the peel-off film 1252 can be the same as the previously described peel-off film 152.

[0097] In some non-limiting embodiments, the cap 1250 can be coupled to the thumb press 1220. For example, the peel-off film 1252 can be coupled to the thumb press 1220. In some non-limiting embodiments, the peel-off film 1252 can be attached to the thumb press 1220. For example, the peel-off film 1252 can be adhered to the thumb press 1220. For example, the peel-off film 1252 can be adhered to the thumb press 1220. In another example, the glass film 1252 can be heat-sealed to the thumb press 1220. In some non-limiting embodiments, the cap 1250 can be removed from the thumb press 1220. For example, the cap 1250 can be removed from the thumb press 1220 by peeling the cap 1250 from the thumb press 1220.

[0098] In some non-limiting embodiments, the pre-filled syringe 1200 can include a scrubbing device. In some non-limiting embodiments, the scrubbing device can be the same as the previously described scrubbing device 170. In some non-limiting embodiments, the scrubbing device can be coupled (e.g., attached, connected, and / or the like) to the pre-filled syringe 1200. In some non-limiting embodiments, the scrubbing device can be connected to the pre-filled syringe 1200 via a Luer connector 1218.

[0099] Although embodiments or aspects have been described in detail for the purposes of illustration and description, it should be understood that such detail is for that purpose only, and that the embodiments or aspects are not limited to the disclosed embodiments or aspects, but, on the contrary, are intended to cover modifications and equivalent arrangements within the spirit and scope of the appended claims. For example, it should be understood that the present disclosure contemplates that, to the extent possible, one or more features of any embodiment or aspect may be combined with one or more features of any other embodiment or aspect. In fact, many of these features may be combined in ways not specifically listed in the claims and / or disclosed in the specification. Although each dependent claim listed below may be directly dependent on only one claim, the disclosure that may be implemented includes each dependent claim in combination with every other claim in the claim set.

Claims

1. A prefilled syringe, comprising: A cartridge, comprising: a proximal end portion, a distal end portion, and a sidewall extending between the proximal end portion and the distal end portion, the sidewall defining a chamber containing a medical solution; a plunger rod, the plunger rod comprising a proximal end portion and a distal end portion; a stopper attached to a distal end of the plunger rod and movably received in the chamber; and A sterile cap is releasably coupled to the prefilled syringe, the sterile cap comprising a housing defining an interior configured to retain a sterile solution.

2. The prefilled syringe according to claim 1, wherein: The plunger also includes: a thumb press at the proximal end of the plunger rod; and a socket positioned between the plunger rod and the plunger thumb press; Wherein, the disinfection cap is contained in the socket.

3. The prefilled syringe according to claim 1, wherein: The plunger also includes: a thumb press at the proximal end of the plunger rod; and a cap retainer including a lock and positioned between the plunger rod and the thumb press, wherein the disinfection cap includes a pin; and Wherein, the pin is configured to releasably couple with the lock to enable the sterilization cap to be removed from the cap holder.

4. The prefilled syringe according to claim 1, wherein: The plunger also includes: a thumb press at the proximal end of the plunger rod; and a cap retainer attached to the thumb press; Wherein, the sterilization cap is received in the cap holder.

5. The prefilled syringe according to claim 1, wherein: The cartridge also includes: a flange at a proximal end of the barrel, the flange comprising one or more grooves; and Wherein, the sterilization cap includes a guide configured to be positioned within the one or more grooves to releasably attach the sterilization cap to the pre-filled syringe.

6. The prefilled syringe of claim 1, wherein: The disinfection cap comprises: A ring includes a snap connection, wherein the ring is configured to be disposed about an outer surface of the barrel to releasably attach the sterilization cap to the prefilled syringe.

7. The prefilled syringe of claim 1, wherein: The cartridge comprises: a flange at the proximal end of the barrel, the flange including a groove having one or more openings therein, and wherein the sterilization cap comprises a plate including at least one pin, wherein the plate is configured to be positioned within the slot such that the at least one pin is positioned within at least one opening to releasably attach the sterilization cap to the prefilled syringe.

8. The prefilled syringe of claim 1, wherein: The cartridge comprises: a flange at a proximal end of the barrel, the flange including a recess including at least one groove, and Wherein, the disinfection cap includes at least one rib extending axially on an outer surface of the disinfection cap, such that the at least one rib is configured to be positioned within the at least one groove to releasably attach the disinfection cap to the prefilled syringe.

9. The prefilled syringe of claim 1, wherein: The cartridge comprises: a flange at a proximal end of the barrel; and Therein, the sterilization cap includes a peel film that is heat sealed to the flange, thereby attaching the sterilization cap to the pre-filled syringe.

10. The prefilled syringe of claim 1, wherein: The plunger rod comprises: an internal volume at the proximal end of the plunger rod; and A thumb press attached to the internal volume by a hinge, Wherein, the sterilization cap is configured to be positioned within the interior volume of the plunger.

11. The prefilled syringe of claim 10, wherein: The disinfection cap is configured to be releasably attached to an inner surface of the thumb press.

12. The prefilled syringe of claim 1 , further comprising a tie having a first end and a second end, wherein The first end is attached to the pre-filled syringe and the second end is attached to the sterile cap.

13. The prefilled syringe of claim 1, wherein: The plunger rod comprises: A thumb press at the proximal end of the plunger rod, wherein a peel-away film of the sterilization cap is attached to the thumb press.

14. The prefilled syringe according to any one of claims 1 to 13, wherein: The disinfecting solution includes alcohol.

15. The prefilled syringe according to any one of claims 1 to 14, wherein The medical solution is an irrigation solution.

16. The prefilled syringe according to any one of claims 1 to 14, wherein: The medical solution is a catheter lock solution.

17. The prefilled syringe according to any one of claims 1 to 16, wherein: The barrel includes a Luer connector at its distal end.

18. The prefilled syringe of claim 17, wherein: The prefilled syringe also includes a swabbing device releasably coupled to the luer connector, the swabbing device including a housing defining an interior configured to retain a disinfecting solution.

19. The prefilled syringe of claim 18, wherein: The disinfecting solution includes alcohol.

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