Electrophoresis-assisted ultrasonic synergistic supercritical extraction and synchronous purification device and method

Abstract

The invention belongs to the technical field of liquid separation and purification, and particularly relates to an electrophoresis-assisted ultrasonic synergistic supercritical extraction and synchronous purification device and method. The liquid outlet end of the supercritical liquefied carbon dioxide supply device is communicated with the liquid inlet end of the extraction reaction kettle, and the supercritical liquefied carbon dioxide supply device is used for providing extraction liquid; the liquid inlet end of the extraction liquid separation tank is communicated with the liquid outlet end of the extraction reaction kettle through a liquid outlet valve, and the liquid outlet end of the extraction liquid separation tank is communicated with a stock solution collector; the discharging end of the feeding device is communicated with the feeding end of the extraction reaction kettle, and the feeding device is used for feeding materials; the ultrasonic module is arranged in the extraction reaction kettle and is used for stirring materials; the temperature control module is arranged in the extraction reaction kettle and is used for controlling the temperature in the extraction reaction kettle; the feeding end of the electrophoresis impurity collecting mechanism is communicated with one side of the bottom of the extraction reaction kettle, and the electrophoresis impurity collecting mechanism is used for collecting impurities.

Description

Technical Field

[0001] The invention belongs to the technical field of liquid separation and purification, and in particular relates to an electrophoresis-assisted ultrasound-assisted supercritical extraction and synchronous purification device and method. Background Art

[0002] As people's health awareness grows, the concept of medicine and food having the same origin is gradually gaining popularity and becoming an important force in promoting the development of the modern nutrition and health industry. However, common medicinal materials and food ingredients contain a lot of impurities, which are difficult for the human body to absorb, and are difficult to store for a long time and inconvenient to carry, resulting in low utilization rates of these medicinal materials and food ingredients, difficulty in extracting ingredients, and great waste.

[0003] The main purpose of extraction is to separate and extract specific components from a mixture. Extraction uses the difference in solubility of different substances in solvents to extract the target compound from the original sample, thereby achieving the purpose of separation and purification.

[0004] Traditional extraction methods include solvent extraction, ultrasonic extraction, microwave-assisted extraction, and enzyme extraction. However, the extraction efficiency of solvent extraction is low, the extraction time is too long, and the thermal effect on the raw materials may destroy the effective components and activity of the device; the penetration depth of microwaves in microwave-assisted extraction is limited (at the same order of magnitude as its wavelength), and its mass transfer function in the enhanced extraction process is not obvious; ultrasonic vibration in ultrasonic extraction makes the material easy to break, although it can improve the extraction efficiency of the stock solution, but the fine powder is easy to clog the equipment, the later maintenance cost is relatively high, and the equipment investment is high, the operation is complicated, and the applicable plant materials are limited. There are many influencing factors in the enzyme extraction method, the extraction process is relatively complicated, the extraction time is relatively long, and the extraction rate is not high. It can be seen that the above methods cannot achieve the ideal extraction effect.

[0005] Supercritical fluid extraction is an advanced physical extraction technology that combines traditional distillation and organic solvent extraction, and uses supercritical CO2 as a solvent to effectively separate, extract and purify the matrix and the extract. Supercritical CO2 has a diffusion coefficient similar to that of gas and a solubility of liquid, with a surface tension of zero, and can quickly penetrate into solid substances. In the supercritical state, the supercritical fluid is brought into contact with the substance to be separated, so that it can selectively extract components of different polarity, boiling point and relative molecular mass in turn. It has the characteristics of high efficiency, non-oxidation, pure naturalness and no chemical pollution.

[0006] Based on the above advantages, we propose an electrophoresis-assisted ultrasound-assisted supercritical extraction and synchronous purification device and method. Summary of the invention

[0007] The purpose of the present invention is to provide an electrophoresis-assisted ultrasound-assisted supercritical extraction and synchronous purification device and method to solve the above problems.

[0008] To achieve the above object, the present invention provides the following solutions:

[0009] An electrophoresis-assisted ultrasound-assisted supercritical extraction and synchronous purification device, comprising:

[0010] Extraction reactor;

[0011] A supercritical liquefied carbon dioxide supply device, whose liquid outlet is connected to the liquid inlet of the extraction reactor, for providing extraction liquid;

[0012] An extract liquid separation tank, the liquid inlet end of which is connected to the liquid outlet end of the extraction reactor through a liquid outlet valve, and the liquid outlet end of the extract liquid separation tank is connected to a stock liquid collector;

[0013] A feeding device, the discharge end of which is connected to the feed end of the extraction reactor, for feeding materials;

[0014] An ultrasonic module is disposed in the extraction reactor and is used to stir the material;

[0015] A temperature control module, disposed in the extraction reactor, for controlling the temperature in the extraction reactor;

[0016] The electrophoresis impurity collection mechanism has a feed end connected to one side of the bottom of the extraction reactor and is used to collect impurities.

[0017] The supercritical liquefied carbon dioxide supply device provides supercritical carbon dioxide to the extraction reactor, and the ultrasonic module generates ultrasonic waves, which are used to destroy the cell walls of the raw materials. The active components in the raw material cells dissolve and migrate into the supercritical carbon dioxide under the mechanical and thermal effects of the ultrasonic waves, thereby achieving the extraction of the active components of the raw materials.

[0018] Optionally, the supercritical liquefied carbon dioxide supply device includes:

[0019] Gaseous carbon dioxide storage tank, used for supplying gaseous carbon dioxide;

[0020] A carbon dioxide liquefaction component, the air inlet end of which is connected to the gaseous carbon dioxide storage tank, and the liquid outlet end of which is connected to the liquid carbon dioxide storage tank;

[0021] A carbon dioxide pump, wherein the liquid inlet end is connected to the liquid outlet end of the liquid carbon dioxide storage tank, and the liquid outlet end of the carbon dioxide pump is connected to the liquid inlet end of the extraction reactor through a heater.

[0022] Optionally, the carbon dioxide liquefaction component includes:

[0023] An adjustable booster pump connected to the gas outlet of the gaseous carbon dioxide storage tank;

[0024] The air inlet of the condenser is connected to the air outlet of the adjustable booster pump, and the liquid outlet of the condenser is connected to the liquid inlet of the liquid carbon dioxide storage tank through a liquid inlet valve. The condenser is used for liquefying gaseous carbon dioxide.

[0025] Optionally, one side of the extraction liquid separation tank is connected to the air inlet end of the gaseous carbon dioxide storage tank through a recovery valve.

[0026] Optionally, a membrane filter is provided on the top of the extraction liquid separation tank, and the membrane filter is used to filter particulate matter in the liquid entering the extraction liquid separation tank.

[0027] Optionally, the feeding device comprises:

[0028] A raw material input valve is used to input the raw material into the extraction reactor.

[0029] Optionally, the electrophoretic impurity collection mechanism includes:

[0030] A pipeline, one end of which is connected to the discharge end of the extraction reactor, and the other end of which is connected to the liquid inlet end of the impurity collection chamber through a recovery pump. The top liquid outlet end of the impurity collection chamber is connected to the raw material input valve through a pressure reducing valve. The top liquid outlet end of the impurity collection chamber is provided with an impurity filtering device. The carbon dioxide extract containing impurities in the impurity collection chamber is filtered by the impurity filtering device and then flows back to the extraction reactor through the pressure reducing valve and the raw material input valve;

[0031] The electrophoresis auxiliary electrode is arranged in the pipeline and is used for adsorbing impurities.

[0032] Optionally, the ultrasound module includes:

[0033] The transducer is fixed in the extraction reaction kettle and is transmission-connected with an ultrasonic amplifier.

[0034] Optionally, the temperature control module includes:

[0035] A temperature controller, fixed in the extraction reactor;

[0036] A controllable heating disk is fixed in the extraction reaction kettle and is electrically connected to the temperature controller. The controllable heating disk is used to control the temperature in the extraction reaction kettle.

[0037] An electrophoresis-assisted ultrasound-assisted supercritical extraction and simultaneous purification method, based on the above-mentioned electrophoresis-assisted ultrasound-assisted supercritical extraction and simultaneous purification device, comprises the following steps:

[0038] Feeding the material into the extraction reactor through the feeding device;

[0039] Using the supercritical liquefied carbon dioxide supply device to provide liquid carbon dioxide extract into the extraction reactor;

[0040] Using the ultrasonic module to stir the material put into the extraction reactor;

[0041] Using the temperature control module to control the temperature in the extraction reactor;

[0042] Use the mechanical and thermal effects of ultrasound to promote the dissolution and migration of active ingredients in raw material tissues;

[0043] Using the electrophoresis impurity collection mechanism to collect impurities in the extract;

[0044] The extract enters the extract separation tank from the extraction reaction kettle for separation, and the separated raw liquid is output to the raw liquid collector.

[0045] Compared with the prior art, the present invention has the following advantages and technical effects:

[0046] The present invention further improves the extraction process by combining the advantages of ultrasonic extraction and supercritical extraction, creatively utilizes the thermal effect, mechanical effect and cavitation effect generated by the ultrasonic module, and realizes the effect of gradually assisting supercritical fluid extraction. At the same time, the electrophoretic characteristics of ultrafine powder particles of ultrasonic crushing are utilized, and the dispersion of powder particles is controlled by the auxiliary electric field. The electrophoretic effect is utilized to adsorb and remove the impurities of micro-nano scale that are difficult to remove by ordinary filtering methods, thereby further purifying the extract and further purifying the extracted liquid. The present invention can remove impurities while extracting, thereby improving the purity and effective ingredients of the drug; improve the utilization of raw materials, concentrate the active ingredients in the raw materials and improve their bioavailability, so that the absorption, distribution, metabolism and excretion process of the drug in the body are more efficient; maintain the stability of the drug, and the conditions such as temperature and pH value can be controlled during the extraction process, thereby maintaining the stability of the drug and extending its shelf life; improve the therapeutic effect, and by accurately extracting and proportioning the effective ingredients in the plants, the dosage and concentration of the drug can be better controlled, thereby improving the effect of the active ingredients. BRIEF DESCRIPTION OF THE DRAWINGS

[0047] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments are briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative labor:

[0048] Figure 1 It is a schematic diagram of the structure of the present invention;

[0049] Figure 2 This is a schematic diagram of the internal structure of the extraction reactor of the present invention;

[0050] Among them, 1. Gaseous carbon dioxide storage tank; 2. Adjustable booster pump; 3. Condenser; 4. Liquid inlet valve; 5. Liquid carbon dioxide storage tank; 6. Carbon dioxide pump; 7. Heater; 8. Recovery valve; 9. Extraction reactor; 10. Raw material input valve; 11. Ultrasonic module; 12. Recovery pump; 13. Liquid outlet valve; 14. Membrane filter; 15. Extraction liquid separation tank; 16. Raw liquid collector; 17. Temperature controller; 18. Ultrasonic amplifier; 19. Transducer; 20. Ultrasonic and temperature control power supply; 21. Controllable heating plate; 22. Electrophoresis auxiliary electrode; 23. Electrophoresis auxiliary power supply; 24. Impurity collection chamber; 25. Impurity filtering device; 26. Pressure reducing valve. DETAILED DESCRIPTION

[0051] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0052] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0053] Reference Figure 1 to Figure 2 The present invention discloses an electrophoresis-assisted ultrasound-assisted supercritical extraction and synchronous purification device, comprising:

[0054] Extraction reactor 9;

[0055] A supercritical liquefied carbon dioxide supply device, the liquid outlet of which is connected to the liquid inlet of the extraction reactor 9, for providing an extraction liquid;

[0056] The extract separation tank 15 has a liquid inlet connected to the liquid outlet of the extraction reactor 9 through a liquid outlet valve 13, and the liquid outlet of the extract separation tank 15 is connected to a stock liquid collector 16;

[0057] A feeding device, the discharge end of which is connected to the feed end of the extraction reactor 9, for feeding materials;

[0058] The ultrasonic module 11 is arranged in the extraction reactor 9 and is used to stir the material;

[0059] The temperature control module is arranged in the extraction reaction kettle 9 and is used to control the temperature in the extraction reaction kettle 9;

[0060] The electrophoresis impurity collection mechanism has a feed end connected to one side of the bottom of the extraction reactor 9 for collecting impurities.

[0061] The supercritical liquefied carbon dioxide supply device provides supercritical carbon dioxide to the extraction reactor 9, and the ultrasonic module 11 generates ultrasonic waves, which are used to destroy the cell walls of the raw materials. The active components in the raw material cells dissolve and migrate into the supercritical carbon dioxide under the mechanical and thermal effects of the ultrasonic waves, thereby realizing the extraction of the active components of the raw materials.

[0062] When in use, the material is put into the extraction reactor 9 through the feeding device, and the supercritical liquefied carbon dioxide supply device is used to provide liquid carbon dioxide extraction liquid into the extraction reactor 9. The ultrasonic module 11 is used to stir the material put into the extraction reactor 9. The temperature in the extraction reactor 9 is controlled by the temperature control module. The mechanical and thermal effects of ultrasound are used to promote the dissolution and migration of active ingredients in the raw material tissue. The impurities in the extract are collected by the electrophoresis impurity collection mechanism. The extract enters the extraction liquid separation tank 15 from the extraction reactor 9 for separation, and the separated raw liquid is output to the raw liquid collector 16.

[0063] The present invention further improves the extraction process by combining the advantages of ultrasonic extraction and supercritical extraction, and creatively utilizes the thermal effect, mechanical effect and cavitation effect generated by the ultrasonic module 11 to achieve a step-by-step auxiliary supercritical fluid extraction effect. At the same time, the electrophoretic characteristics of ultrafine powder particles are utilized to control the dispersion of powder particles through an auxiliary electric field, and the electrophoretic effect is utilized to adsorb and remove micro-nanoscale impurities that are difficult to remove by ordinary filtering methods, thereby further purifying the extract. The present invention can remove impurities while extracting, thereby improving the purity and effective ingredients of the drug; improve the utilization of raw materials, concentrate the active ingredients in the raw materials and improve their bioavailability, so that the absorption, distribution, metabolism and excretion process of the drug in the body are more efficient; maintain the stability of the drug, and control the temperature, pH value and other conditions during the extraction process, thereby maintaining the stability of the drug and extending its shelf life; improve the therapeutic effect, and by accurately extracting and proportioning the effective ingredients in the plant, the dosage and concentration of the drug can be better controlled, thereby improving the effect of the active ingredients.

[0064] As an optional embodiment, the supercritical liquefied carbon dioxide supply device includes:

[0065] A gaseous carbon dioxide storage tank 1, used for supplying gaseous carbon dioxide;

[0066] The carbon dioxide liquefaction component has an air inlet connected to a gaseous carbon dioxide storage tank 1, and a liquid outlet connected to a liquid carbon dioxide storage tank 5;

[0067] The liquid inlet end of the carbon dioxide pump 6 is connected to the liquid outlet end of the liquid carbon dioxide storage tank 5 , and the liquid outlet end of the carbon dioxide pump 6 is connected to the liquid inlet end of the extraction reactor 9 through the heater 7 .

[0068] As an optional embodiment, the carbon dioxide liquefaction component includes:

[0069] An adjustable booster pump 2 is connected to the gas outlet of the gaseous carbon dioxide storage tank 1;

[0070] The air inlet end of the condenser 3 is connected to the air outlet end of the adjustable booster pump 2, and the liquid outlet end of the condenser 3 is connected to the liquid inlet end of the liquid carbon dioxide storage tank 5 through the liquid inlet valve 4. The condenser 3 is used for liquefying gaseous carbon dioxide.

[0071] As an optional implementation, one side of the extraction liquid separation tank 15 is connected to the air inlet end of the gaseous carbon dioxide storage tank 1 through the recovery valve 8 .

[0072] As an optional implementation, a membrane filter 14 is disposed on the top of the extraction liquid separation tank 15 , and the membrane filter 14 is used to filter particulate matter in the liquid entering the extraction liquid separation tank 15 .

[0073] As an optional embodiment, the feeding device includes:

[0074] The raw material input valve 10 , through which the raw material is input into the extraction reactor 9 .

[0075] As an optional implementation, the electrophoretic impurity collection mechanism includes:

[0076] A pipeline, one end of which is connected to the discharge end of the extraction reactor 9, and the other end of which is connected to the liquid inlet end of the impurity collection chamber 24 through a recovery pump 12. The top liquid outlet end of the impurity collection chamber 24 is connected to the raw material input valve 10 through a pressure reducing valve 26. The top liquid outlet end of the impurity collection chamber 24 is provided with an impurity filtering device 25. The carbon dioxide extract containing impurities in the impurity collection chamber 24 is filtered by the impurity filtering device 25 and then flows back to the extraction reactor 9 through the pressure reducing valve 26 and the raw material input valve 10;

[0077] The electrophoresis auxiliary electrode 22 is arranged in the pipeline and is used to absorb impurities.

[0078] As an optional implementation, the ultrasound module 11 includes:

[0079] The transducer 19 is fixed in the extraction reactor 9 and is connected to the ultrasonic amplifier 18 in a transmission manner.

[0080] As an optional implementation, the temperature control module includes:

[0081] A temperature controller 17 is fixed in the extraction reactor 9;

[0082] The controllable heating disk 21 is fixed in the extraction reaction kettle 9 and is electrically connected to the temperature controller 17 . The controllable heating disk 21 is used to control the temperature in the extraction reaction kettle 9 .

[0083] The present invention mainly comprises a gaseous carbon dioxide storage tank 1, a liquid carbon dioxide storage tank 5, an extraction reactor 9, an extraction liquid separation tank 15, an ultrasonic module 11, an electrophoresis impurity collection mechanism, and necessary pipelines and valves.

[0084] The gaseous carbon dioxide storage tank 1 stores sufficient and clean carbon dioxide gas, which is connected to the adjustable booster pump 2 and the condenser 3 through an output pipeline. The adjustable booster pump 2 can adjust the output pressure according to the properties of carbon dioxide required for the extraction reaction, and combined with the function of the condenser 3, the carbon dioxide is liquefied and stored in the liquid carbon dioxide storage tank 5.

[0085] The liquid inlet valve 4 can control the volume of carbon dioxide entering the liquid carbon dioxide storage tank 5 to maintain the pressure therein.

[0086] The carbon dioxide pump 6 can transport the liquefied carbon dioxide to the extraction reactor 9, and the heater 7 can control the temperature of the liquid carbon dioxide according to the reaction requirements.

[0087] The extraction reaction kettle 9 is connected to the liquid carbon dioxide storage tank 5, the carbon dioxide pump 6 and the heater 7 through pipelines to ensure the smooth progress of the extraction reaction.

[0088] The pretreated raw materials can enter the extraction reactor 9 through the raw material input valve 10 .

[0089] The extraction reactor 9 is also equipped with an ultrasonic module 11, a temperature controller 17 and an electrophoretic impurity collection mechanism, etc., to realize the electrophoresis-assisted ultrasonic-synergistic supercritical extraction and synchronous purification process.

[0090] The temperature controller 17 in the extraction reactor 9 can ensure the temperature requirements of the extraction reaction in different stages, and monitor and adjust the temperature in real time through ultrasound and temperature control power supply 20.

[0091] The ultrasonic module 11 includes an ultrasonic amplifier 18 and a transducer 19 .

[0092] The ultrasonic and temperature control power supply 20 is electrically connected to the temperature controller 17 , the transducer 19 , and the controllable heating plate 21 .

[0093] When the ultrasonic module 11 is working, the power supply 20 is controlled by ultrasound and temperature to start the operation of the transducer 19, generating high-frequency ultrasonic vibrations. The vibrations generated by the transducer 19 can be adjusted in amplitude through a super-sonic amplitude device to further adapt to the different characteristics of the raw materials and take advantage of the advantages of composite ultrasonic extraction to improve the extraction efficiency of the raw materials.

[0094] The controllable heating plate 21 can provide different temperatures according to different extraction stages, and with the help of the strong convection effect of ultrasonic vibration, the temperature in the entire reactor can be quickly controlled.

[0095] An impurity output pipeline is provided at the lower end of the extraction reactor 9, and an electrophoresis auxiliary electrode 22 is provided in the pipeline. An auxiliary electric field is formed between the electrophoresis auxiliary electrodes 22 through the electrophoresis auxiliary power supply 23. Through the auxiliary electric field drive and the action of the recovery pump 12, the electrophoresis effect is utilized to adsorb and remove micro-nanoscale impurities that are difficult to remove by ordinary filtering methods, and collect them in the impurity collection chamber 24.

[0096] Under the control of the electrophoresis auxiliary power supply 23 , the electrophoresis auxiliary electrode 22 can realize polarity conversion between electrodes to adapt to the adsorption of different types of powder particles and heavy metal pollutants.

[0097] After being adsorbed, the powder particles and heavy metal pollutants are pumped toward the impurity collection chamber 24 by the recovery pump 12 .

[0098] The impurity filtering device 25 is installed in the impurity collecting chamber 24, and the supercritical carbon dioxide is gasified and separated through the recovery pump 12 and the pressure reducing valve 26, and the powder impurities are precipitated and collected in the impurity collecting chamber 24. Part of the gasified carbon dioxide can re-enter the extraction reactor 9 through the raw material input valve 10 to adjust the internal pressure.

[0099] The extracted raw liquid passes through the liquid outlet valve 13 and flows through the membrane filter 14 for further purification, and then enters the extraction liquid separation tank 15. Through the pressure adjustment of the liquid outlet valve 13, the carbon dioxide is gasified and separated, and returns to the gaseous carbon dioxide storage tank 1 through the pipeline and the recovery valve 8.

[0100] The raw liquid separated from the carbon dioxide is transported to the raw liquid collector 16 to complete the extraction process.

[0101] The present invention also provides an electrophoresis-assisted ultrasound-assisted supercritical extraction and synchronous purification process. The supercritical carbon dioxide medium described in the present invention is just a medium selected for the convenience of describing, and other supercritical media are also suitable for the device described in the present invention.

[0102] An electrophoresis-assisted ultrasound-assisted supercritical extraction and simultaneous purification method, based on the above-mentioned electrophoresis-assisted ultrasound-assisted supercritical extraction and simultaneous purification device, comprises the following steps:

[0103] The material is fed into the extraction reactor 9 through the feeding device;

[0104] Using a supercritical liquefied carbon dioxide supply device to provide liquid carbon dioxide extract into the extraction reactor 9;

[0105] The material put into the extraction reactor 9 is crushed by using the ultrasonic module 11;

[0106] Use a temperature control module to control the temperature in the extraction reactor 9;

[0107] Use the mechanical and thermal effects of ultrasound to promote the dissolution and migration of active ingredients in raw material tissues;

[0108] The impurities in the extract are collected using an electrophoresis impurity collection mechanism;

[0109] The extract enters the extract separation tank 15 from the extraction reaction kettle 9 for separation, and the separated raw liquid is output to the raw liquid collector 16 .

[0110] The working principle of the present invention is as follows:

[0111] Different from the conventional supercritical extraction method, the supercritical carbon dioxide in the present invention remains in liquid form when it is input into the extraction liquid reactor. With the action of the pressure reducing valve 26, the liquid carbon dioxide is gradually converted into supercritical carbon dioxide, and the diffusion rate can reach about 100 times that of the liquid state, so as to achieve the maximum extraction of the raw material components. The raw materials after pretreatment are placed in the reactor at the same time, and the mechanical and thermal effects of ultrasound are used to promote the dissolution and migration of active ingredients in the raw material tissue. Under the action of ultrasound, the cell wall of the raw material is destroyed, and the internal active ingredients can be quickly released into the supercritical carbon dioxide solvent for preliminary extraction. At the same time, the thermal effect generated by the transducer and the ultrasonic amplitude device will heat a part of the liquid carbon dioxide. Combined with the controllable heating plate and the temperature controller, the liquid carbon dioxide is kept at a suitable temperature to further extract the active ingredients of the raw material.

[0112] At the same time, the powder particles produced by raw material pretreatment, crushing, etc. and the heavy metal pollutants that may be brought by the raw materials can be adsorbed near the corresponding polarity by the auxiliary electric field of the electrophoresis-assisted inter-electrode component, using the electrophoretic characteristics of the powder particles and the charged characteristics of the heavy metal elements themselves, and then transported to the impurity collection chamber through the recovery pump to achieve the effect of synchronous purification. The supercritical carbon dioxide inside is gasified and separated by the recovery pump and the pressure reducing valve 26, and the powder impurities are precipitated and collected in the collection chamber. Part of the gasified carbon dioxide can re-enter the reactor through the raw material input valve 10 to adjust its internal pressure. The purified extract passes through a membrane filter to further remove larger particles of raw materials, and then enters the extract separation tank. Combined with the liquid outlet valve, the pressure in the separation tank is adjusted to gasify all supercritical carbon dioxide, and then returns to the storage tank through the pipeline and the recovery valve, while the extracted stock enters the collector, completing the electrophoresis-assisted ultrasonic synergistic supercritical extraction and synchronous purification process.

[0113] In the description of the present invention, it should be understood that the terms "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside" and "outside" etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0114] The embodiments described above are only descriptions of the preferred modes of the present invention, and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims

1. An electrophoresis-assisted ultrasound-assisted supercritical extraction and synchronous purification device, characterized in that: include: Extraction reaction kettle (9); A supercritical liquefied carbon dioxide supply device, the liquid outlet of which is connected to the liquid inlet of the extraction reactor (9), for providing an extraction liquid; An extract separation tank (15), the liquid inlet end of which is connected to the liquid outlet end of the extraction reaction kettle (9) through a liquid outlet valve (13), and the liquid outlet end of the extract separation tank (15) is connected to a stock liquid collector (16); A feeding device, the discharge end of which is connected to the feed end of the extraction reactor (9) for feeding materials; An ultrasonic module (11), arranged in the extraction reaction kettle (9), for stirring the material; A temperature control module, arranged in the extraction reaction kettle (9), and used to control the temperature in the extraction reaction kettle (9); The electrophoresis impurity collection mechanism has a feed end connected to one side of the bottom of the extraction reaction kettle (9) and is used to collect impurities.

2. The electrophoresis-assisted ultrasound-assisted supercritical extraction and synchronous purification device according to claim 1, characterized in that: The supercritical liquefied carbon dioxide supply device comprises: A gaseous carbon dioxide storage tank (1) is used for supplying gaseous carbon dioxide; A carbon dioxide liquefaction component, the air inlet end of which is connected to the gaseous carbon dioxide storage tank (1), and the liquid outlet end of which is connected to the liquid carbon dioxide storage tank (5); A carbon dioxide pump (6) has a liquid inlet end connected to a liquid outlet end of the liquid carbon dioxide storage tank (5), and a liquid outlet end of the carbon dioxide pump (6) is connected to a liquid inlet end of the extraction reaction kettle (9) via a heater (7).

3. The electrophoresis-assisted ultrasound-assisted supercritical extraction and synchronous purification device according to claim 2, characterized in that: The carbon dioxide liquefaction component comprises: An adjustable booster pump (2) is connected to the gas outlet end of the gaseous carbon dioxide storage tank (1); The condenser (3) has an air inlet end connected to the air outlet end of the adjustable booster pump (2), and a liquid outlet end of the condenser (3) connected to the liquid inlet end of the liquid carbon dioxide storage tank (5) via a liquid inlet valve (4). The condenser (3) is used for liquefying gaseous carbon dioxide.

4. The electrophoresis-assisted ultrasound-assisted supercritical extraction and synchronous purification device according to claim 2, characterized in that: One side of the extraction liquid separation tank (15) is connected to the air inlet end of the gaseous carbon dioxide storage tank (1) via a recovery valve (8).

5. The electrophoresis-assisted ultrasound-assisted supercritical extraction and synchronous purification device according to claim 1, characterized in that: A membrane filter (14) is arranged on the top of the extraction liquid separation tank (15), and the membrane filter (14) is used to filter particulate matter in the liquid entering the extraction liquid separation tank (15).

6. The electrophoresis-assisted ultrasound-assisted supercritical extraction and synchronous purification device according to claim 1, characterized in that: The feeding device comprises: A raw material input valve (10) is used to input the raw material into the extraction reaction kettle (9).

7. The electrophoresis-assisted ultrasound-assisted supercritical extraction and simultaneous purification device according to claim 6, characterized in that: The electrophoretic impurity collection mechanism comprises: A pipeline, one end of which is connected to the discharge end of the extraction reaction kettle (9), and the other end of which is connected to the liquid inlet end of the impurity collection chamber (24) through a recovery pump (12); the top liquid outlet end of the impurity collection chamber (24) is connected to the raw material input valve (10) through a pressure reducing valve (26); the top liquid outlet end of the impurity collection chamber (24) is provided with an impurity filtering device (25); the carbon dioxide extract containing impurities in the impurity collection chamber (24) is filtered by the impurity filtering device (25) and then flows back to the extraction reaction kettle (9) through the pressure reducing valve (26) and the raw material input valve (10); The electrophoresis auxiliary electrode (22) is arranged in the pipeline and is used for adsorbing impurities.

8. The electrophoresis-assisted ultrasound-assisted supercritical extraction and synchronous purification device according to claim 1, characterized in that: The ultrasonic module (11) comprises: A transducer (19), wherein the transducer (19) is fixed in the extraction reaction kettle (9), and the transducer (19) is transmission-connected to an ultrasonic amplifier (18).

9. The electrophoresis-assisted ultrasound-assisted supercritical extraction and synchronous purification device according to claim 1, characterized in that: The temperature control module comprises: A temperature controller (17) is fixed in the extraction reaction kettle (9); A controllable heating disk (21) is fixed in the extraction reaction kettle (9) and is electrically connected to the temperature controller (17). The controllable heating disk (21) is used to control the temperature in the extraction reaction kettle (9).

10. An electrophoresis-assisted ultrasound-assisted supercritical extraction and simultaneous purification method, according to an electrophoresis-assisted ultrasound-assisted supercritical extraction and simultaneous purification device according to any one of claims 1-9, characterized in that: The steps include: Feeding the material into the extraction reaction kettle (9) through the feeding device; Using the supercritical liquefied carbon dioxide supply device to provide liquid carbon dioxide extraction liquid into the extraction reaction kettle (9); Using the ultrasonic module (11) to stir the material put into the extraction reaction kettle (9); Using the temperature control module to control the temperature in the extraction reaction kettle (9); Use the mechanical and thermal effects of ultrasound to promote the dissolution and migration of active ingredients in raw material tissues; Using the electrophoresis impurity collection mechanism to further collect impurities in the extract; The extract enters the extract separation tank (15) from the extraction reaction kettle (9) for separation, and the separated raw liquid is output to the raw liquid collector (16).

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