Amonolysis reaction kettle for producing L-prolinamide
By wrapping and reusing ammonia in the ammonia lysis reactor for L-prolylamide production, the problem of ammonia passing through the reaction solvent and wasting is solved, and the reaction rate and production efficiency are significantly improved.
Patent Information
- Application Number
- CN202411979247.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-31
- Publication Date
- 2025-04-15
AI Technical Summary
In the prior art, ammonia gas quickly passes through the reaction solvent in the ammonia-lysis reactor, making it difficult for the solvent to fully contact the ammonia gas, and ammonia gas floats upward and is wasted, and the ammonia gas pressure is insufficient, resulting in slowing the reaction rate and reducing production efficiency.
An ammonia lysis reactor for L-prolymide production was designed. The blades of the arc-shaped plate were used to wrap the ammonia gas with the extension plate, and the ammonia gas was swept into the reaction solvent through the rotation of the blades, increasing the contact area between the reaction solvent and the ammonia gas and improving the reaction efficiency.
By increasing the contact area between ammonia and the reaction solvent, the rate of ammonia lysis reaction is significantly accelerated, the waste of ammonia is reduced, the solubility and reaction efficiency of ammonia in the solvent are improved, and the production efficiency is improved.
Smart Images
Figure CN119819208A_ABST
Abstract
Description
Technical Field
[0001] The invention belongs to the field of L-prolineamide production, in particular to an ammonolysis reaction kettle for L-prolineamide production. Background Art
[0002] L-prolineamide is an important intermediate in the synthesis of many drugs. For example, it plays an important role in the synthesis of some drugs for the treatment of cardiovascular diseases and diabetes. It can participate in the structure, folding and function of proteins, and affect the activity and effect of drugs. It can be used in research in biochemistry and medicinal chemistry, helping researchers to gain a deeper understanding of the structure and function of proteins, as well as the mechanism of action of drugs. In the production of L-prolineamide, aminolysis is a key step. Ammonia gas reacts with L-proline methyl ester hydrochloride, and the solution after the reaction is separated and purified to obtain pure L-prolineamide products.
[0003] In the existing technology, when ammonia is introduced into the ammonolysis reactor to react with the L-proline methyl ester hydrochloride reaction solvent, the ammonia can easily and quickly pass through the reaction solvent, resulting in that many reaction solvents do not have time to contact the ammonia. In addition, the density of ammonia is less than that of air, so the ammonia in the ammonolysis reactor will float upward and accumulate on the top of the ammonolysis reactor until it is discharged. The existing technology is not convenient for reusing the ammonia floating upward, resulting in that the ammonia charged is difficult to react continuously with the reaction solvent, and a large amount of ammonia needs to be continuously input, resulting in a waste of ammonia. In addition, the nitrogen in the ammonolysis reactor will be discharged outward along with the input, resulting in insufficient ammonia pressure in the ammonolysis reactor, resulting in reduced solubility of ammonia in the solvent, and the opportunity of contacting with L-proline methyl ester hydrochloride is also correspondingly reduced, which will slow down the rate of the ammonolysis reaction, prolong the reaction time, and reduce production efficiency.
[0004] To this end, the present invention provides an aminolysis reactor for producing L-prolineamide. Summary of the invention
[0005] In order to make up for the deficiencies of the prior art and solve the problem that, in the prior art, when ammonia is introduced into an ammonolysis reactor to react with an L-proline methyl ester hydrochloride reaction solvent, ammonia can easily and quickly pass through the reaction solvent, resulting in that many reaction solvents do not have time to contact the ammonia, and the density of ammonia is less than that of air, so the ammonia in the ammonolysis reactor will float upward and accumulate on the top of the ammonolysis reactor until it is discharged. The prior art is not convenient for reusing the ammonia floating upward, resulting in that the ammonia charged is difficult to react continuously with the reaction solvent, and a large amount of ammonia needs to be continuously input, resulting in a waste of ammonia. In addition, the nitrogen in the ammonolysis reactor will be discharged outward along with the input, resulting in insufficient ammonia pressure in the ammonolysis reactor, resulting in reduced solubility of ammonia in the solvent, and the opportunity of contacting with L-proline methyl ester hydrochloride is correspondingly reduced, which will slow down the rate of the ammonolysis reaction, prolong the reaction time, and reduce the production efficiency. The present invention provides an ammonolysis reactor for L-prolineamide production.
[0006] The technical solution adopted by the present invention to solve its technical problem is: the aminolysis reactor for L-prolineamide production described in the present invention comprises a reaction tank, the bottom of the reaction tank is fixedly connected with a support foot, the inner wall of the reaction tank is symmetrically fixedly connected with a second baffle, the two second baffles are fixedly connected to each other, the tops of the two second baffles are both set as an arc surface, a gas pipeline is fixedly connected between the two second baffles, one end of the gas pipeline extends to the outside of the reaction tank, the inner wall of the reaction tank and the first baffle is fixedly connected below the two second baffles, the first baffle is set in a herringbone shape, a heating wire is arranged inside the first baffle, the outer wall of the reaction tank and the gas pipeline is fixedly connected with a liquid infusion pipeline, the outer wall of the liquid infusion pipeline is threadedly connected with a first threaded cover, the bottom of the reaction tank is fixedly connected with a liquid outlet pipeline, the outer wall of the liquid outlet pipeline is threadedly connected with a second threaded cover, and the top of the reaction tank is provided with an exhaust port.
[0007] Preferably, the inner wall of the reaction tank is symmetrically rotatably connected with two first rotating shafts located between the first baffle and the second baffle, one end of the two first rotating shafts passes through the reaction tank and are fixedly connected with gears, the two gears are meshingly connected, the outer wall of the reaction tank is fixedly connected with a second motor, the output end of the second motor extends to the inner wall of the reaction tank and is fixedly connected to the other end of one of the first rotating shafts, the outer wall of the first rotating shaft is equidistantly fixedly connected with a plurality of blades, the blades are all arranged in an arc shape, and the outer wall of the blade is fixedly connected with an extension plate.
[0008] Preferably, two first guide plates are symmetrically fixedly connected to the inner wall of the reaction tank and located on the top of the second baffle plate, and the two first guide plates both protrude toward the inner wall of the reaction tank; two second guide plates are symmetrically fixedly connected to the inner wall of the reaction tank and located above the first guide plates, and the two second guide plates are both inclined downward; two third baffles are symmetrically fixedly connected to the inner wall of the reaction tank and located below the second baffle plate, and the two third baffles are both arranged in an arc shape.
[0009] Preferably, the two second baffles are fixedly connected to a second fixed plate on one side away from each other, the two second fixed plates are fixedly connected to the reaction tank, the inner wall of the second fixed plate is symmetrically provided with two second air outlet grooves, the inner wall of the second fixed plate is slidably connected with a sliding shaft between the two second air outlet grooves, the top end of the sliding shaft is fixedly connected to a second partition plate, the second partition plate fits the top of the second fixed plate, the bottom end of the sliding shaft is fixedly connected to a limiting plate, the outer wall of the sliding shaft is provided with a telescopic spring, the top of the telescopic spring is fixedly connected to the second fixed plate, and the bottom of the telescopic spring is fixedly connected to the limiting plate.
[0010] Preferably, a first fixed plate is fixedly connected between the two second guide plates, and two first air outlet grooves are symmetrically opened on the inner wall of the first fixed plate. A first motor is fixedly connected to the top of the reaction tank, and the output end of the first motor extends to the interior of the reaction tank and is fixedly connected to a U-shaped frame, and a second rotating shaft is fixedly connected to the bottom of the U-shaped frame, and a first partition is fixedly connected to the bottom of the second rotating shaft, and the first partition is attached to the top of the first fixed plate, and the cross-section of the first partition is set to an elliptical shape.
[0011] Preferably, two first pipes are symmetrically fixedly connected to the outer wall of the reaction tank, one end of the first pipe extends to the bottom of the third baffle, and the other end of the first pipe extends to the bottom of the second guide plate, and the outer wall of the U-shaped frame is provided with a vacuum assembly.
[0012] Preferably, the vacuum assembly includes two connecting shafts, both of which are rotatably connected to the U-shaped frame and arranged up and down, one end of the two first pipes is fixedly connected to the second pipe, the outer walls of the two second pipes are fixedly connected to the sleeve, the inner walls of the two sleeves are slidably connected to the piston plates, the two connecting shafts are respectively rotatably connected to the two piston plates, and the inner wall of the second pipe is symmetrically provided with two one-way valves with the sleeve as the center, and the two one-way valves are both opened upward.
[0013] Preferably, the other end of the first pipeline is symmetrically fixedly connected to two mounting plates, and the inner walls of the two mounting plates are equidistantly fixedly connected to a plurality of diverter plates, and the plurality of diverter plates are all installed at an angle.
[0014] Preferably, the bottom of the inner wall of the reaction tank is symmetrically rotatably connected to two third rotating shafts, and the outer wall of the third rotating shaft is equidistantly and fixedly connected to a plurality of stirring blades.
[0015] Preferably, a plurality of fixing frames are equidistantly fixedly connected to the bottom of the second baffle, a lower pressing plate is rotatably connected to the inner wall of the fixing frame, and a spring sheet is fixedly connected between the lower pressing plate and the second baffle.
[0016] The beneficial effects of the present invention are as follows: 1. The ammonolysis reactor for L-prolineamide production described in the present invention wraps ammonia gas by using the blades of the arc plate in conjunction with the extension plate. As the blades rotate, the ammonia gas is easily ejected into the L-proline methyl ester hydrochloride reaction solvent, so that the ammonia gas and the L-proline methyl ester hydrochloride reaction solvent can fully react. As the blades rotate, the L-proline methyl ester hydrochloride reaction solvent can be pushed upward, so that the L-proline methyl ester hydrochloride reaction solvent continuously rolls, thereby increasing the contact area with the ammonia gas and accelerating the reaction speed.
[0017] 2. The ammonia decomposition reactor for L-prolineamide production described in the present invention can pump ammonia at the angle between the first guide plate and the second guide plate along the first pipeline into the L-proline methyl ester hydrochloride reaction solvent through the provided exhaust assembly, thereby allowing the ammonia to enter the L-proline methyl ester hydrochloride reaction solvent for reaction, which not only improves the reaction effect of ammonia with the L-proline methyl ester hydrochloride reaction solvent, but also can reuse the ammonia floating upward.
[0018] 3. The ammonia decomposition reactor for L-prolineamide production described in the present invention blocks the second gas outlet slot by means of a telescopic spring in cooperation with a second baffle, so that ammonia cannot pass directly through, thereby increasing the ammonia pressure below the second baffle, increasing the solubility of ammonia, and allowing more ammonia to dissolve in the L-proline methyl ester hydrochloride reaction solvent. When the ammonia pressure continues to increase, the second baffle is pushed upward by the pressure, compressing the telescopic spring and properly discharging the ammonia below the second baffle.
[0019] 4. The aminolysis reactor for L-prolineamide production described in the present invention blocks the ammonia gas entering the L-proline methyl ester hydrochloride reaction solvent by setting two third baffles and the first baffle, thereby preventing the ammonia gas from passing through the L-proline methyl ester hydrochloride reaction solvent too quickly and flowing upward. BRIEF DESCRIPTION OF THE DRAWINGS
[0020] The present invention will be further described below in conjunction with the accompanying drawings.
[0021] Figure 1 is a front view of the present invention; Figure 2 is a rear view of the present invention; Figure 3 is a cross-sectional view of the present invention; Figure 4 is a cross-sectional view from another perspective of the present invention; Figure 5 It is a three-dimensional diagram of the installation plate and the diverter plate of the present invention in cooperation with each other; Figure 6 It is a three-dimensional diagram of the first baffle, the second baffle and the third baffle of the present invention used in combination; Figure 7 It is a three-dimensional diagram of the second baffle plate and the lower pressure plate of the present invention in cooperation with each other; Figure 8 The present invention Figure 3 The enlarged view of point A in the middle; Fig. 9 The present invention Figure 3 The enlarged view of point B in the middle; Fig.10 The present invention Figure 3 Enlarged view of point C in the middle; Fig.11 The present invention Figure 4 The enlarged view of point D in the middle; In the figure: 1, reaction tank; 2, liquid delivery pipeline; 3, first threaded cover; 4, liquid outlet pipeline; 5, second threaded cover; 6, gas delivery pipeline; 7, exhaust port; 8, first baffle; 9, heating wire; 10, second baffle; 11, first rotating shaft; 12, blade; 13, extension plate; 14, fixing frame; 15, lower pressure plate; 16, spring sheet; 17, third baffle; 18, first guide plate; 19, second guide plate; 20, first pipeline; 21, second pipeline; 22, sleeve; 2 3. Piston plate; 24. One-way valve; 25. First motor; 26. U-shaped frame; 27. Connecting shaft; 28. Second rotating shaft; 29. First fixed plate; 30. First air outlet groove; 31. First partition plate; 32. Second fixed plate; 33. Second air outlet groove; 34. Sliding shaft; 35. Second partition plate; 36. Telescopic spring; 37. Limiting plate; 38. Mounting plate; 39. Diverter plate; 40. Second motor; 41. Gear; 42. Third rotating shaft; 43. Stirring blade; 44. Support foot. DETAILED DESCRIPTION
[0022] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further explained below in conjunction with specific implementation methods.
[0023] like Figures 1 to 11As shown, the present invention provides a technical solution, an ammonolysis reactor for L-prolineamide production, comprising a reaction tank 1, a support leg 44 is fixedly connected to the bottom of the reaction tank 1, a second baffle 10 is symmetrically fixedly connected to the inner wall of the reaction tank 1, the two second baffles 10 are fixedly connected to each other, the tops of the two second baffles 10 are both set as cambered surfaces, a gas pipeline 6 is fixedly connected between the two second baffles 10, one end of the gas pipeline 6 extends to the outside of the reaction tank 1, a first baffle 8 is fixedly connected to the inner wall of the reaction tank 1 and located below the two second baffles 10, the first baffle 8 is set in a herringbone shape, a heating wire 9 is arranged inside the first baffle 8, a liquid infusion pipeline 2 is fixedly connected to the outer wall of the reaction tank 1 and located below the gas pipeline 6, the outer wall of the liquid infusion pipeline 2 is threadedly connected to the first threaded cover 3, a liquid outlet pipeline 4 is fixedly connected to the bottom of the reaction tank 1, the outer wall of the liquid outlet pipeline 4 is threadedly connected to the second threaded cover 5, and an exhaust port 7 is opened at the top of the reaction tank 1.
[0024] Through the above technical scheme, the L-proline methyl ester hydrochloride reaction solvent is poured into the reaction tank 1 along the liquid infusion pipe 2, the liquid infusion pipe 2 is sealed by the first threaded cover 3, ammonia is injected into the reaction tank 1 through the gas pipe 6 to react with the L-proline methyl ester hydrochloride reaction solvent, the heating wire 9 is started to heat the L-proline methyl ester hydrochloride reaction solvent to increase the reaction rate, the ammonia is blocked by the two second baffles 10 to prevent the ammonia from floating upward too quickly, and the contact time between the ammonia and the L-proline methyl ester hydrochloride reaction solvent is prolonged, the reacted ammonia is discharged from the reaction tank 1 along the exhaust port 7 through the exhaust port 7, the second threaded cover 5 is rotated to open the liquid outlet pipe 4, and the reacted L-proline methyl ester hydrochloride reaction solvent is taken out.
[0025] Specifically, the inner wall of the reaction tank 1 is symmetrically connected to two first rotating shafts 11 between the first baffle 8 and the second baffle 10, one end of the two first rotating shafts 11 passes through the reaction tank 1 and is fixedly connected to a gear 41, the two gears 41 are meshingly connected, the outer wall of the reaction tank 1 is fixedly connected to a second motor 40, the output end of the second motor 40 extends to the inner wall of the reaction tank 1 and is fixedly connected to the other end of one of the first rotating shafts 11, the outer wall of the first rotating shaft 11 is equidistantly fixedly connected to a plurality of blades 12, the blades 12 are all arranged in an arc shape, and the outer wall of the blade 12 is fixedly connected to an extension plate 13.
[0026] Through the above technical solution, the liquid surface of the L-proline methyl ester hydrochloride reaction solvent is level with the first rotating shaft 11, and the second motor 40 is started to drive one of the first rotating shafts 11 to rotate, so that the corresponding gear 41 rotates, and drives the other gear 41 to rotate, so that the other first rotating shaft 11 rotates. When the two first rotating shafts 11 rotate, the two sets of blades 12 are driven to rotate at the same time, and the blades 12 of the arc plate cooperate with the extension plate 13 to wrap the ammonia. With the rotation of the blades 12, it is convenient to shoot the ammonia into the L-proline methyl ester hydrochloride reaction solvent, so that the ammonia and the L-proline methyl ester hydrochloride reaction solvent react fully, and with the rotation of the blades 12, the L-proline methyl ester hydrochloride reaction solvent can be pushed upward, so that the L-proline methyl ester hydrochloride reaction solvent rolls continuously, thereby increasing the contact area with the ammonia and accelerating the reaction speed.
[0027] Specifically, two first guide plates 18 are symmetrically fixedly connected to the inner wall of the reaction tank 1 and located on the top of the second baffle plate 10, and the two first guide plates 18 both protrude toward the inner wall of the reaction tank 1. Two second guide plates 19 are symmetrically fixedly connected to the inner wall of the reaction tank 1 and located above the first guide plates 18, and the two second guide plates 19 are both inclined downward. Two third baffles 17 are symmetrically fixedly connected to the inner wall of the reaction tank 1 and located below the second baffle plate 10, and the two third baffles 17 are both arranged in an arc shape.
[0028] Through the above technical scheme, the two third baffles 17 are provided to block the ammonia gas entering the L-proline methyl ester hydrochloride reaction solvent from floating upward, thereby preventing the ammonia gas from passing through the L-proline methyl ester hydrochloride reaction solvent too quickly and flowing upward. The two first guide plates 18 are provided in cooperation with the two second baffles 10 to narrow the flow channel of the ammonia gas, further delaying the upward flow of the ammonia gas. Under the guiding action of the two first guide plates 18 and the two second guide plates 19, the ammonia gas floating upward is accumulated at the angle between the first guide plate 18 and the second guide plate 19.
[0029] Specifically, the two second baffles 10 are fixedly connected to the sides away from each other with a second fixed plate 32, and the two second fixed plates 32 are fixedly connected to the reaction tank 1. The inner wall of the second fixed plate 32 is symmetrically provided with two second air outlet grooves 33. The inner wall of the second fixed plate 32 is slidably connected with a sliding shaft 34 located between the two second air outlet grooves 33. The top of the sliding shaft 34 is fixedly connected with a second partition plate 35, and the second partition plate 35 fits the top of the second fixed plate 32. The bottom end of the sliding shaft 34 is fixedly connected with a limiting plate 37. The outer wall of the sliding shaft 34 is sleeved with a telescopic spring 36. The top of the telescopic spring 36 is fixedly connected to the second fixed plate 32, and the bottom of the telescopic spring 36 is fixedly connected to the limiting plate 37.
[0030] Through the above technical scheme, the second gas outlet groove 33 is set to facilitate ammonia to pass through and flow upward. The telescopic spring 36 is set to cooperate with the second baffle 35 to block the second gas outlet groove 33, so that the ammonia cannot pass directly, thereby increasing the ammonia pressure below the second baffle 10, so that the solubility of ammonia will increase, and more ammonia will be dissolved in the L-proline methyl ester hydrochloride reaction solvent. When the ammonia pressure continues to increase, the second baffle 35 is pushed upward under the action of pressure, driving the sliding shaft 34 to move upward, so that the limit plate 37 moves upward, compressing the telescopic spring 36, and the second baffle 35 no longer blocks the second gas outlet groove 33 after moving upward, and the ammonia below the second baffle 10 is properly discharged.
[0031] Specifically, a first fixed plate 29 is fixedly connected between the two second guide plates 19, and two first air outlet grooves 30 are symmetrically opened on the inner wall of the first fixed plate 29. A first motor 25 is fixedly connected to the top of the reaction tank 1, and the output end of the first motor 25 extends to the interior of the reaction tank 1 and is fixedly connected to a U-shaped frame 26. A second rotating shaft 28 is fixedly connected to the bottom of the U-shaped frame 26, and a first partition 31 is fixedly connected to the bottom of the second rotating shaft 28. The first partition 31 is attached to the top of the first fixed plate 29, and the top view of the first partition 31 is set to an elliptical shape.
[0032] Through the above technical scheme, the first air outlet groove 30 is set to facilitate ammonia to flow upward through the first fixed plate 29, and the first motor 25 is started to drive the U-shaped frame 26 to rotate, so that the second rotating shaft 28 rotates, and the first partition plate 31 is driven to rotate. When the longer ends of the first partition plate 31 are rotated to the horizontal direction, the two first air outlet grooves 30 are blocked to prevent ammonia from passing through the first air outlet grooves 30, thereby extending the residence time of ammonia at the angle between the first guide plate 18 and the second guide plate 19. When the shorter ends of the first partition plate 31 are rotated to the horizontal direction, the two first air outlet grooves 30 are opened to facilitate the release of ammonia.
[0033] Specifically, two first pipes 20 are symmetrically fixedly connected to the outer wall of the reaction tank 1, one end of the first pipe 20 extends to the bottom of the third baffle 17, and the other end of the first pipe 20 extends to the bottom of the second guide plate 19, and the outer wall of the U-shaped frame 26 is provided with a vacuum assembly.
[0034] Through the above technical solution, the ammonia gas at the angle between the first guide plate 18 and the second guide plate 19 is pumped into the L-proline methyl ester hydrochloride reaction solvent along the first pipe 20 through the set exhaust assembly, so that the ammonia gas enters the L-proline methyl ester hydrochloride reaction solvent for reaction, which not only improves the reaction effect of the ammonia gas with the L-proline methyl ester hydrochloride reaction solvent, but also can reuse the ammonia gas floating upward, and the ammonia gas entering the L-proline methyl ester hydrochloride reaction solvent is blocked by the set first baffle 8 to prevent the ammonia gas from passing through the L-proline methyl ester hydrochloride reaction solvent too quickly and flowing upward.
[0035] Specifically, the vacuum assembly includes two connecting shafts 27, which are rotatably connected to the U-shaped frame 26 and arranged up and down. One end of the two first pipes 20 is fixedly connected to the second pipe 21, the outer walls of the two second pipes 21 are fixedly connected to the sleeves 22, and the inner walls of the two sleeves 22 are slidably connected to the piston plates 23. The two connecting shafts 27 are rotatably connected to the two piston plates 23 respectively, and the inner wall of the second pipe 21 is symmetrically provided with two one-way valves 24 with the sleeve 22 as the center, and the two one-way valves 24 are both opened upward.
[0036] By means of the above technical solution, the first motor 25 starts and drives the U-shaped frame 26 to rotate at the same time. When the end of the U-shaped frame 26 rotates to the left, the piston plate 23 on the left is driven to be squeezed through the provided connecting shaft 27. When the end of the U-shaped frame 26 rotates to the right, the piston plate 23 on the right is driven to be squeezed through the provided connecting shaft 27. Thus, the two piston plates 23 move back and forth intermittently. When the piston plate 23 moves toward the U-shaped frame 26, the ammonia gas at the angle between the first guide plate 18 and the second guide plate 19 can be drawn into the sleeve 22 along the second pipeline 21 through the cooperation of the two one-way valves 24. When the piston plate 23 moves toward the first pipeline 20, the ammonia gas in the sleeve 22 can be squeezed into the L-proline methyl ester hydrochloride reaction solvent along the first pipeline 20 through the cooperation of the two one-way valves 24.
[0037] Specifically, two mounting plates 38 are symmetrically fixedly connected to the other end of the first pipeline 20 , and a plurality of diverter plates 39 are equidistantly fixedly connected to the inner walls of the two mounting plates 38 , and the plurality of diverter plates 39 are all installed at an angle.
[0038] Through the above technical solution, the ammonia gas squeezed out from the first pipeline 20 enters between the two mounting plates 38, and is diverted by a plurality of diverter plates 39, so that the ammonia gas is formed into multiple streams and enters the L-proline methyl ester hydrochloride reaction solvent from different directions, so that the ammonia gas can be evenly mixed with the L-proline methyl ester hydrochloride reaction solvent, so as to facilitate a full reaction with the L-proline methyl ester hydrochloride reaction solvent.
[0039] Specifically, two third rotating shafts 42 are symmetrically rotatably connected to the bottom of the inner wall of the reaction tank 1, and a plurality of stirring blades 43 are equidistantly and fixedly connected to the outer wall of the third rotating shaft 42.
[0040] Through the above technical solution, when ammonia is discharged from the diverter plate 39, it impacts the stirring blades 43, and the plurality of stirring blades 43 are rotated under the action of the airflow. Through the stirring action of the plurality of stirring blades 43, not only the mixing effect of ammonia and the L-proline methyl ester hydrochloride reaction solvent is improved, but also the precipitation of the L-proline methyl ester hydrochloride reaction solvent is avoided.
[0041] Specifically, a plurality of fixing frames 14 are equidistantly fixedly connected to the bottom of the second baffle 10 , a lower pressing plate 15 is rotatably connected to the inner wall of the fixing frame 14 , and a spring sheet 16 is fixedly connected between the lower pressing plate 15 and the second baffle 10 .
[0042] Through the above technical solution, when the blade 12 rotates, it pushes the lower pressure plate 15 to rotate in the fixed frame 14, pressing the spring sheet 16. As the blade 12 rotates, when the blade 12 breaks away from the lower pressure plate 15, under the action of the spring sheet 16, the lower pressure plate 15 is quickly slapped downward, thereby allowing the ammonia accumulated at the bottom of the second baffle 10 to flow downward, making it easier for it to enter the package of the blade 12 and the extension plate 13.
[0043] When in use, the L-proline methyl ester hydrochloride reaction solvent is poured into the reaction tank 1 along the infusion pipe 2, and the liquid level is level with the first rotating shaft 11, the infusion pipe 2 is sealed by the first threaded cover 3, ammonia is injected into the reaction tank 1 through the gas pipe 6 to react with the L-proline methyl ester hydrochloride reaction solvent, the heating wire 9 is started to heat the L-proline methyl ester hydrochloride reaction solvent to increase the reaction rate, the ammonia is blocked by the two second baffles 10 to prevent the ammonia from floating upward too quickly, and the contact time between the ammonia and the L-proline methyl ester hydrochloride reaction solvent is prolonged, the second motor 40 is started to drive one of the first rotating shafts 11 to rotate, so that the corresponding gear 41 rotates, and the other gear 41 rotates, so that the other first rotating shaft 11 rotates, and the two first rotating shafts 11 rotate while driving the two sets of blades 12 to rotate simultaneously. The blades 12 of the arc plate cooperate with the extension plate 13 to wrap the ammonia. As the blades 12 rotate, it is convenient to shoot the ammonia into the L-proline methyl ester hydrochloride reaction solvent, so that the ammonia and the L-proline methyl ester hydrochloride reaction solvent fully react. As the blades 12 rotate, the L-proline methyl ester hydrochloride reaction solvent can be pushed upward, so that the L-proline methyl ester hydrochloride reaction solvent rolls continuously, increasing the contact area with the ammonia and accelerating the reaction speed. When the blades 12 rotate, the lower pressure plate 15 is pushed to rotate in the fixing frame 14 to press the spring sheet 16. As the blades 12 rotate, when the blades 12 are separated from the lower pressure plate 15, the spring sheet 1 6, the lower pressure plate 15 is quickly slapped downward, so that the ammonia gas stored at the bottom of the second baffle plate 10 flows downward, which is convenient for entering the package of the blade 12 and the extension plate 13. The two third baffle plates 17 are provided to block the ammonia gas entering the L-proline methyl ester hydrochloride reaction solvent to prevent the ammonia gas from passing through the L-proline methyl ester hydrochloride reaction solvent too quickly and flowing upward. The second gas outlet groove 33 is provided to facilitate the ammonia gas to pass through and flow upward. The second gas outlet groove 33 is blocked by the telescopic spring 36 provided in cooperation with the second partition plate 35, so that the ammonia gas cannot pass through directly, thereby increasing the ammonia gas pressure below the second baffle plate 10, so that the ammonia gas solubility will increase, and more ammonia gas will be dissolved in the L-proline methyl ester hydrochloride reaction solvent. When the gas pressure of ammonia continues to increase, the second baffle 35 is pushed upward under the action of pressure, driving the sliding shaft 34 to move upward, causing the limit plate 37 to move upward, compressing the telescopic spring 36, and the second baffle 35 no longer blocks the second gas outlet slot 33 after moving upward, and properly discharges the ammonia below the second baffle 10. The two first guide plates 18 are coordinated with the two second baffles 10 to narrow the flow channel of ammonia, further delaying the upward flow of ammonia, and under the guidance of the two first guide plates 18 and the two second guide plates 19, the ammonia floating upward is accumulated at the angle between the first guide plate 18 and the second guide plate 19, and the first gas outlet slot 30 is provided to facilitate the ammonia to pass through the first fixed plate 29 and flow upward, and the first motor 25 is started.The U-shaped frame 26 is driven to rotate, so that the second rotating shaft 28 rotates, and the first partition plate 31 is driven to rotate. When the longer ends of the first partition plate 31 rotate horizontally, the two first gas outlet grooves 30 are blocked to prevent ammonia from passing through the first gas outlet grooves 30, and the residence time of ammonia at the angle between the first guide plate 18 and the second guide plate 19 is prolonged. When the shorter ends of the first partition plate 31 rotate horizontally, the two first gas outlet grooves 30 are opened to facilitate the release of ammonia. When the end of the U-shaped frame 26 rotates to the left, the connecting shaft 27 is provided, and the When the end of the U-shaped frame 26 rotates to the right, the piston plate 23 on the right is driven to be squeezed through the provided connecting shaft 27, thereby reciprocating, so that the two piston plates 23 intermittently reciprocate left and right. When the piston plate 23 moves toward the U-shaped frame 26, the ammonia gas at the angle between the first guide plate 18 and the second guide plate 19 can be drawn into the sleeve 22 along the second pipeline 21 through the cooperation of the two one-way valves 24. When the piston plate 23 moves toward the first pipeline 20, the ammonia gas at the angle between the first guide plate 18 and the second guide plate 19 can be drawn into the sleeve 22 through the cooperation of the two one-way valves 24. , the ammonia gas in the sleeve 22 can be squeezed into the L-proline methyl ester hydrochloride reaction solvent along the first pipe 20, and the ammonia gas squeezed out from the first pipe 20 enters between the two mounting plates 38, and is split by a plurality of splitter plates 39, so that the ammonia gas forms multiple streams and enters the L-proline methyl ester hydrochloride reaction solvent from different directions, so that the ammonia gas can be evenly mixed with the L-proline methyl ester hydrochloride reaction solvent, which not only improves the reaction effect of the ammonia gas with the L-proline methyl ester hydrochloride reaction solvent, but also can be used to treat the ammonia gas floating upward The ammonia gas entering the L-proline methyl ester hydrochloride reaction solvent is blocked by the first baffle 8 to prevent the ammonia gas from passing through the L-proline methyl ester hydrochloride reaction solvent too quickly and flowing upward. When the ammonia gas is discharged from the diverter plate 39, it impacts the stirring blade 43, and the plurality of stirring blades 43 are rotated under the action of the airflow. Under the stirring action of the plurality of stirring blades 43, the mixing effect of the ammonia gas and the L-proline methyl ester hydrochloride reaction solvent is not only improved, but also the precipitation of the L-proline methyl ester hydrochloride reaction solvent is avoided.
[0044] The above-mentioned front, back, left, right, top and bottom are all based on the figures in the specification. Figure 1 As a benchmark, according to the person's observation perspective, the side of the device facing the observer is defined as the front, the left side of the observer is defined as the left, and so on.
[0045] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the scope of protection of the present invention.
[0046] The above shows and describes the basic principles, main features and advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments. The above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention. The scope of protection of the present invention is defined by the attached claims and their equivalents.
Claims
1. An ammonolysis reactor for L-prolineamide production, characterized in that: The invention comprises a reaction tank (1), wherein a support foot (44) is fixedly connected to the bottom of the reaction tank (1), a second baffle (10) is symmetrically fixedly connected to the inner wall of the reaction tank (1), two second baffles (10) are fixedly connected to each other, the tops of the two second baffles (10) are both arranged as an arc surface, a gas pipeline (6) is fixedly connected between the two second baffles (10), one end of the gas pipeline (6) extends to the outside of the reaction tank (1), and the inner wall of the reaction tank (1) and located below the two second baffles (10) are fixedly connected A first baffle (8) is connected, the first baffle (8) is arranged in a herringbone shape, a heating wire (9) is arranged inside the first baffle (8), a liquid infusion pipeline (2) is fixedly connected to the outer wall of the reaction tank (1) and located below the gas transmission pipeline (6), a first threaded cover (3) is threadedly connected to the outer wall of the liquid infusion pipeline (2), a liquid outlet pipeline (4) is fixedly connected to the bottom of the reaction tank (1), a second threaded cover (5) is threadedly connected to the outer wall of the liquid outlet pipeline (4), and an exhaust port (7) is opened at the top of the reaction tank (1).
2. The aminolysis reactor for producing L-prolineamide according to claim 1, characterized in that: The inner wall of the reaction tank (1) is symmetrically connected to two first rotating shafts (11) located between the first baffle plate (8) and the second baffle plate (10), one end of each of the two first rotating shafts (11) passes through the reaction tank (1) and is fixedly connected to a gear (41), the two gears (41) are meshingly connected, the outer wall of the reaction tank (1) is fixedly connected to a second motor (40), the output end of the second motor (40) extends to the inner wall of the reaction tank (1) and is fixedly connected to the other end of one of the first rotating shafts (11), the outer wall of the first rotating shaft (11) is fixedly connected to a plurality of blades (12) at equal intervals, the blades (12) are all arranged in an arc shape, and the outer wall of the blade (12) is fixedly connected to an extension plate (13).
3. The aminolysis reactor for L-prolineamide production according to claim 2, characterized in that: Two first guide plates (18) are symmetrically fixedly connected to the inner wall of the reaction tank (1) and located on the top of the second baffle plate (10), and the two first guide plates (18) both protrude toward the inner wall of the reaction tank (1); two second guide plates (19) are symmetrically fixedly connected to the inner wall of the reaction tank (1) and located above the first guide plates (18), and the two second guide plates (19) are both inclined downward; and two third baffle plates (17) are symmetrically fixedly connected to the inner wall of the reaction tank (1) and located below the second baffle plate (10), and the two third baffle plates (17) are both arranged in an arc shape.
4. The aminolysis reactor for producing L-prolineamide according to claim 3, characterized in that: A second fixing plate (32) is fixedly connected to one side of the two second baffle plates (10) that is away from each other. The two second fixing plates (32) are fixedly connected to the reaction tank (1). Two second air outlet grooves (33) are symmetrically provided on the inner wall of the second fixing plate (32). A sliding shaft (34) is slidably connected to the inner wall of the second fixing plate (32) and located between the two second air outlet grooves (33). A second partition plate (35) is fixedly connected to the top of the sliding shaft (34). The second partition plate (35) fits the top of the second fixing plate (32). A limiting plate (37) is fixedly connected to the bottom of the sliding shaft (34). A telescopic spring (36) is sleeved on the outer wall of the sliding shaft (34). The top of the telescopic spring (36) is fixedly connected to the second fixing plate (32), and the bottom of the telescopic spring (36) is fixedly connected to the limiting plate (37).
5. The aminolysis reactor for producing L-prolineamide according to claim 4, characterized in that: A first fixed plate (29) is fixedly connected between the two second guide plates (19); two first air outlet grooves (30) are symmetrically provided on the inner wall of the first fixed plate (29); a first motor (25) is fixedly connected to the top of the reaction tank (1); an output end of the first motor (25) extends into the interior of the reaction tank (1) and is fixedly connected to a U-shaped frame (26); a second rotating shaft (28) is fixedly connected to the bottom of the U-shaped frame (26); a first partition (31) is fixedly connected to the bottom of the second rotating shaft (28); the first partition (31) is attached to the top of the first fixed plate (29); and a cross section of the first partition (31) is set to be elliptical.
6. The aminolysis reactor for producing L-prolineamide according to claim 5, characterized in that: Two first pipes (20) are symmetrically and fixedly connected to the outer wall of the reaction tank (1), one end of the first pipe (20) extends below the third baffle (17), and the other end of the first pipe (20) extends below the second guide plate (19), and the outer wall of the U-shaped frame (26) is provided with an exhaust assembly.
7. The aminolysis reactor for producing L-prolineamide according to claim 6, characterized in that: The air extraction assembly comprises two connecting shafts (27), the two connecting shafts (27) are rotatably connected to the U-shaped frame (26) and are arranged up and down, one end of the two first pipes (20) is fixedly connected to the second pipe (21), the outer walls of the two second pipes (21) are fixedly connected to the sleeve (22), the inner walls of the two sleeves (22) are slidably connected to the piston plate (23), the two connecting shafts (27) are rotatably connected to the two piston plates (23), and the inner wall of the second pipe (21) is symmetrically provided with two one-way valves (24) with the sleeve (22) as the center, and the two one-way valves (24) are both open upward.
8. The aminolysis reactor for producing L-prolineamide according to claim 7, characterized in that: The other end of the first pipeline (20) is symmetrically fixedly connected to two mounting plates (38), and the inner walls of the two mounting plates (38) are equidistantly fixedly connected to a plurality of flow divider plates (39), and the plurality of flow divider plates (39) are all installed at an angle.
9. The aminolysis reactor for producing L-prolineamide according to claim 8, characterized in that: The bottom of the inner wall of the reaction tank (1) is symmetrically rotatably connected to two third rotating shafts (42), and the outer wall of the third rotating shaft (42) is equidistantly and fixedly connected to a plurality of stirring blades (43).
10. The aminolysis reactor for producing L-prolineamide according to claim 9, characterized in that: A plurality of fixing frames (14) are equidistantly fixedly connected to the bottom of the second baffle (10); a lower pressing plate (15) is rotatably connected to the inner wall of the fixing frame (14); and a spring sheet (16) is fixedly connected between the lower pressing plate (15) and the second baffle (10).